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BTBD10 Gene

protein-coding   GIFtS: 51
GCID: GC11M013409

BTB (POZ) Domain Containing 10

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
BTB (POZ) Domain Containing 101 2     K+ Channel Tetramerization Protein2
GMRP-12     KLHL415
GMRP12     KSARCOSIN5
BTB (Broad-Complex Tramtrack And Bric-A-Brac/Pox Virus And Zinc Finger)
Domain-Containing Protein 102
     NEM95
BTB/POZ Domain-Containing Protein 102     

External Ids:    HGNC: 214451   Entrez Gene: 842802   Ensembl: ENSG000001489257   OMIM: 6077015   UniProtKB: Q9BSF83   

Export aliases for BTBD10 gene to outside databases

Previous GC identifers: GC11M013367 GC11M013089


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for BTBD10 Gene:
BTBD10 (BTB (POZ) domain containing 10) is a protein-coding gene. Diseases associated with BTBD10 include long qt syndrome, and lateral sclerosis. An important paralog of this gene is KCTD20.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BTBD10 gene promoter:
         Nkx3-1   Nkx3-1 v4   MAZR   Nkx3-1 v1   GATA-2   GATA-1   MEF-2A   Nkx3-1 v2   Nkx3-1 v3   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBTBD10 promoter sequence
   Search Chromatin IP Primers for BTBD10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BTBD10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.2   Ensembl cytogenetic band:  11p15.2   HGNC cytogenetic band: 11p15.2

BTBD10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BTBD10 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M013409:  view genomic region     (about GC identifiers)

Start:
13,409,548 bp from pter      End:
13,484,844 bp from pter
Size:
75,297 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: BTBDA_HUMAN, Q9BSF8 (See protein sequence)
Recommended Name: BTB/POZ domain-containing protein 10  
Size: 475 amino acids; 53779 Da
Secondary accessions: Q86WG1

Explore the universe of human proteins at neXtProt for BTBD10: NX_Q9BSF8

Explore proteomics data for BTBD10 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys157, Lys211
  • Modification sites at PhosphoSitePlus

  • See BTBD10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115696.2  
    ENSEMBL proteins: 
     ENSP00000278174   ENSP00000435303   ENSP00000431186   ENSP00000435257   ENSP00000434857  
     ENSP00000434579   ENSP00000431572  

    BTBD10 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for BTBD10

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    Abcam antibodies for BTBD10
    Cloud-Clone Corp. Antibodies for BTBD10
    ThermoFisher Antibodies for BTBD10
    LSBio Antibodies in human, mouse, rat for BTBD10

    BTBD10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BTBD10
    Cloud-Clone Corp. CLIAs for BTBD10


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTBD: BTB/POZ domain containing

    2 InterPro protein domains:
     IPR000210 BTB/POZ-like
     IPR011333 BTB/POZ_fold

    Graphical View of Domain Structure for InterPro Entry Q9BSF8

    ProtoNet protein and cluster: Q9BSF8

    1 Blocks protein domain: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: BTBDA_HUMAN, Q9BSF8
    Similarity: Contains 1 BTB (POZ) domain


    BTBD10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    BTBD10 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Btbd10 (no phenotypes)

    BTBD10 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BTBD10
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BTBD10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BTBD10

    miRNA
    Products:
        
    miRTarBase miRNAs that target BTBD10:
    hsa-mir-328-3p (MIRT043765), hsa-mir-19b-3p (MIRT031244), hsa-mir-93-5p (MIRT028112), hsa-mir-340-5p (MIRT019640), hsa-mir-130b-3p (MIRT020297)

    Block miRNA regulation of human, mouse, rat BTBD10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BTBD10 (see all 24):
    hsa-miR-142-5p hsa-miR-30c hsa-miR-106a hsa-miR-30d hsa-miR-340 hsa-miR-9 hsa-miR-30a hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidBTBD10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BTBD10
    Predesigned siRNA for gene silencing in human, mouse, rat BTBD10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BTBD10

    Clone
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    OriGene clones in human, mouse for BTBD10 (see all 6)
    OriGene ORF clones in mouse, rat for BTBD10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BTBD10 (NM_006063)
    Sino Biological Human cDNA Clone for BTBD10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BTBD10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTBD10

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for BTBD10 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTBD10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BTBDA_HUMAN, Q9BSF8: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----

    BTBD10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BTBD10
    Interactions:

        Search GeneGlobe Interaction Network for BTBD10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for BTBD10 (Q9BSF82, 3 ENSP000002781744) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DLG5Q8TDM62, 3MINT-65326 I2D: score=5 
    ACIN1Q9UKV32, 3MINT-65328 I2D: score=4 
    CDC37Q165432, 3MINT-8250789 I2D: score=2 
    MAPK3P273612, 3, ENSP000002630254MINT-8260559 I2D: score=2 STRING: ENSP00000263025
    LAMA5O152303, ENSP000002529994I2D: score=3 STRING: ENSP00000252999
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BTBD10 (BTBDA)

    3 Novoseek inferred chemical compound relationships for BTBD10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    potassium 53.9 1 18947437 (1)
    calcium 0 3 8569066 (2), 9582078 (1)
    tyrosine 0 2 7929599 (1), 8702786 (1)



    BTBD10 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for BTBD10 gene: 
    NM_032320.5  

    Unigene Cluster for BTBD10:

    BTB (POZ) domain containing 10
    Hs.332382  [show with all ESTs]
    Unigene Representative Sequence: AY221959
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000278174(uc010rcl.2 uc001mkz.3 uc009ygn.3 uc010rcm.2)
    ENST00000527102 ENST00000530907 ENST00000528120 ENST00000525864(uc010rcn.2 uc009ygo.3)
    ENST00000525661 ENST00000525108 ENST00000532261 ENST00000529708 ENST00000526841
    ENST00000527858
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat BTBD10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BTBD10 (see all 24):
    hsa-miR-142-5p hsa-miR-30c hsa-miR-106a hsa-miR-30d hsa-miR-340 hsa-miR-9 hsa-miR-30a hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidBTBD10 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for BTBD10
    Predesigned siRNA for gene silencing in human, mouse, rat BTBD10
    Clone
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    OriGene clones in human, mouse for BTBD10 (see all 6)
    OriGene ORF clones in mouse, rat for BTBD10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BTBD10 (NM_006063)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BTBD10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BTBD10
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for BTBD10
    OriGene qSTAR qPCR primer pairs in human, mouse for BTBD10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BTBD10
      QuantiTect SYBR Green Assays in human, mouse, rat BTBD10
      QuantiFast Probe-based Assays in human, mouse, rat BTBD10

    Additional mRNA sequence: 

    AF329102.2 AK095946.1 AK292392.1 AK294259.1 AK294768.1 AK298226.1 AK310935.1 AK316163.1 
    AL832981.1 AY221959.2 BC005071.1 BC017072.1 BC062633.1 

    14 DOTS entries:

    DT.116960  DT.95171604  DT.95171596  DT.120684700  DT.101970153  DT.40107956  DT.120684683  DT.91798002 
    DT.95188646  DT.100798652  DT.120684706  DT.91753515  DT.100644109  DT.99956565 

    Selected AceView cDNA sequences (see all 184):

    BC005071 CD108229 BQ212428 AA366477 AA988000 Z39002 AI653990 AI276909 
    AK095946 AA866042 AI277280 BM754654 AA397688 AA207052 CB265710 BE295419 
    W51750 AI929806 BQ771830 BM977656 AI246323 BM751340 R43398 CA429537 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BTBD10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGGAGTGT
    BTBD10 Expression
    About this image

    BTBD10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BTBD10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.332382

    UniProtKB/Swiss-Prot: BTBDA_HUMAN, Q9BSF8
    Tissue specificity: Ubiquitously expressed. Highly expressed in adult brain, testis and small intestine and weakly
    expressed in the heart, lung, liver, kidney, pancreas, spleen, thymus, prostate, ovary and colon. Down-regulated
    in glioma

        Custom PCR Arrays for BTBD10
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BTBD10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for BTBD10 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Btbd101 , 5 BTB (POZ) domain containing 101, 5 92.07(n)1
    97.26(a)1
      7 (59.18 cM)5
    688151  NM_133700.21  NP_598461.11 
     1133156265 
    chicken
    (Gallus gallus)
    Aves BTBD101 BTB (POZ) domain containing 10 83.07(n)
    94.78(a)
      423029  NM_001199575.1  NP_001186504.1 
    lizard
    (Anolis carolinensis)
    Reptilia BTBD106
    BTB (POZ) domain containing 10
    88(a)
    1 ↔ 1
    GL343237.1(1481338-1511497)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.41912 Xenopus laevis transcribed sequence with moderate similarity more 82.45(n)    CA986052.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa12a082 wufa12a08 79.96(n)   335028  57041395 
    fruit fly
    (Drosophila melanogaster)
    Insecta mri6
    mrityu
    47(a)
    1 → many
    3L(200174-202152)
    worm
    (Caenorhabditis elegans)
    Secernentea snpc-1.46
    Protein BTBD-10, isoform d (btbd-10) mRNA, complet...
    35(a)
    1 → many
    II(4905011-4911835) WBGene00019888
    rice
    (Oryza sativa)
    Liliopsida BI805536.12   -- 91.43(n)    BI805536.1 


    ENSEMBL Gene Tree for BTBD10 (if available)
    TreeFam Gene Tree for BTBD10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BTBD10 gene
    KCTD202  
    1 SIMAP similar gene for BTBD10 using alignment to 10 protein entries:     BTBDA_HUMAN (see all proteins):
    KCTD20

    BTBD10 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for BTBD10
    PGOHUM00000257949 PGOHUM00000243813


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BTBD10 (see all 1333)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2020181571,2
    --13409401(+) ATAAA-/TATTGTTT 1 -- int10--------
    rs1136888321,2
    F--13409476(+) TCCTTG/TAGCTA 1 -- int12Minor allele frequency- T:0.50CSA 4
    rs110227841,2
    C,F,A--13409501(+) ACTTAC/TACCAC 1 -- int19Minor allele frequency- T:0.17NA WA EA 506
    rs563154071,2
    C--13409591(+) TATTTC/TGATGA 1 -- ut310--------
    rs1505661511,2
    C--13409792(+) GCTCTA/GGAGAT 1 -- ut310--------
    rs10444321,2
    C,F,H--13409798(-) TCAGTT/AATCTC 1 -- ut3126Minor allele frequency- A:0.14MN NS EA NA WA 2606
    rs10444311,2
    C,F,O,H--13409843(-) TATCTG/AAATGA 1 -- ut3128Minor allele frequency- A:0.14MN NS EA NA WA 3098
    rs1905436461,2
    --13409846(+) TTCAGA/GTAAGC 1 -- ut310--------
    rs1386077871,2
    --13409925(+) CAGAAA/GCACTT 1 -- ut310--------
    rs1823801181,2
    --13410245(+) AAAAAA/GGCCTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for BTBD10 (13409548 - 13484844 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for BTBD10: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BTBD10
    DNA2.0 Custom Variant and Variant Library Synthesis for BTBD10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607701   
    OMIM disorders: 615731  
    7 diseases for BTBD10:    About MalaCards
    long qt syndrome    lateral sclerosis    amyotrophic lateral sclerosis    pancreatitis
    malaria    neuronitis    prostatitis


    BTBD10 for disorders           About GeneDecksing

    Genetic Association Database (GAD): BTBD10
    Human Genome Epidemiology (HuGE) Navigator: BTBD10 (1 document)

    Export disorders for BTBD10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BTBD10 gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with BTBD10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel human BTB domain- containing gene, BTBD10, which is down-regulated in glioma. (PubMed id 15556295)1, 2, 3, 9 Chen J.... Lu Y. (Gene 2004)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Reduced expression of BTBD10 in anterior horn cells with Golgi fragmentation and pTDP-43-positive inclusions in patients with sporadic amyotrophic lateral sclerosis. (PubMed id 23320755)1 Furuta N....Okamoto K. (Neuropathology 2013)
    5. Protein phosphatase 1I^ isoforms linked interactions in the brain. (PubMed id 23080069)1 Esteves S.L....da Cruz e Silva E.F. (J. Mol. Neurosci. 2013)
    6. Protein phosphatase 1I+ interacting proteins in the human brain. (PubMed id 22321011)1 Esteves S.L....da Cruz e Silva E.F. (OMICS 2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. Reduced expression of BTBD10, an Akt activator, leads to motor neuron death. (PubMed id 22388351)1 Nawa M....Matsuoka M. (Cell Death Differ. 2012)
    9. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    10. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84280 HGNC: 21445 AceView: GMRP-1 Ensembl:ENSG00000148925 euGenes: HUgn84280
    ECgene: BTBD10 H-InvDB: BTBD10

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BTBD10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BTBD10 gene:
    Search GeneIP for patents involving BTBD10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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