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Aliases for BTBD10 Gene

Aliases for BTBD10 Gene

  • BTB (POZ) Domain Containing 10 2 3
  • Glucose Metabolism-Related Protein 1 3 4
  • GMRP1 3 4
  • BTB (Broad-Complex Tramtrack And Bric-A-Brac/Pox Virus And Zinc Finger) Domain-Containing Protein 10 3
  • BTB/POZ Domain-Containing Protein 10 3
  • K+ Channel Tetramerization Protein 3
  • GMRP-1 3

External Ids for BTBD10 Gene

Summaries for BTBD10 Gene

GeneCards Summary for BTBD10 Gene

BTBD10 (BTB (POZ) Domain Containing 10) is a Protein Coding gene. Diseases associated with BTBD10 include nemaline myopathy 9. An important paralog of this gene is KCTD20.

UniProtKB/Swiss-Prot for BTBD10 Gene

  • Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTBD10 Gene

Genomics for BTBD10 Gene

Genomic Location for BTBD10 Gene

Start:
13,388,001 bp from pter
End:
13,463,297 bp from pter
Size:
75,297 bases
Orientation:
Minus strand

Genomic View for BTBD10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BTBD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTBD10 Gene

Regulatory Elements for BTBD10 Gene

Proteins for BTBD10 Gene

  • Protein details for BTBD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSF8-BTBDA_HUMAN
    Recommended name:
    BTB/POZ domain-containing protein 10
    Protein Accession:
    Q9BSF8
    Secondary Accessions:
    • B7Z228
    • Q86WG1

    Protein attributes for BTBD10 Gene

    Size:
    475 amino acids
    Molecular mass:
    53779 Da
    Quaternary structure:
    • Interacts (via C-terminal 330-amino-acid region) with AKT1; AKT2 and AKT3. Interacts with PPP2CA and PPP1CA.

    Alternative splice isoforms for BTBD10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BTBD10 Gene

Proteomics data for BTBD10 Gene at MOPED

Post-translational modifications for BTBD10 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys157 and Lys211

No data available for DME Specific Peptides for BTBD10 Gene

Domains for BTBD10 Gene

Gene Families for BTBD10 Gene

HGNC:
  • BTBD :BTB/POZ domain containing

Protein Domains for BTBD10 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

BTBDA_HUMAN
Domain:
  • Contains 1 BTB (POZ) domain.:
    • Q9BSF8
genes like me logo Genes that share domains with BTBD10: view

Function for BTBD10 Gene

Molecular function for BTBD10 Gene

UniProtKB/Swiss-Prot Function: Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells.

Gene Ontology (GO) - Molecular Function for BTBD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with BTBD10: view

miRNA for BTBD10 Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for BTBD10 Gene

Localization for BTBD10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTBD10 Gene

Nucleus. Cytoplasm. Note=Colocalizes with KCTD20 in filamentous structures. {ECO:0000250 UniProtKB:Q80X66}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BTBD10 Gene COMPARTMENTS Subcellular localization image for BTBD10 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for BTBD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with BTBD10: view

Pathways for BTBD10 Gene

SuperPathways for BTBD10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BTBD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042327 positive regulation of phosphorylation ISS --
GO:0044342 type B pancreatic cell proliferation ISS --
GO:1901215 negative regulation of neuron death ISS --
genes like me logo Genes that share ontologies with BTBD10: view

No data available for Pathways by source for BTBD10 Gene

Compounds for BTBD10 Gene

(3) Novoseek inferred chemical compound relationships for BTBD10 Gene

Compound -log(P) Hits PubMed IDs
potassium 53.9 1
calcium 0 3
tyrosine 0 2
genes like me logo Genes that share compounds with BTBD10: view

Transcripts for BTBD10 Gene

Unigene Clusters for BTBD10 Gene

BTB (POZ) domain containing 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BTBD10 Gene

No ASD Table

Relevant External Links for BTBD10 Gene

GeneLoc Exon Structure for
BTBD10
ECgene alternative splicing isoforms for
BTBD10

Expression for BTBD10 Gene

mRNA expression in normal human tissues for BTBD10 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BTBD10 Gene

SOURCE GeneReport for Unigene cluster for BTBD10 Gene Hs.332382

mRNA Expression by UniProt/SwissProt for BTBD10 Gene

Q9BSF8-BTBDA_HUMAN
Tissue specificity: Ubiquitously expressed. Highly expressed in adult brain, testis, aorta and small intestine and weakly expressed in the heart, lung, liver, kidney, pancreas, spleen, thymus, prostate, ovary and colon. Down-regulated in glioma.
genes like me logo Genes that share expressions with BTBD10: view

Orthologs for BTBD10 Gene

This gene was present in the common ancestor of animals.

Orthologs for BTBD10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BTBD10 36
  • 99.86 (n)
  • 100 (a)
BTBD10 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BTBD10 36
  • 92.6 (n)
  • 97.09 (a)
BTBD10 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BTBD10 36
  • 95.02 (n)
  • 98.11 (a)
BTBD10 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Btbd10 36
  • 92.07 (n)
  • 97.26 (a)
Btbd10 16
Btbd10 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BTBD10 37
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BTBD10 37
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Btbd10 36
  • 91.26 (n)
  • 97.42 (a)
chicken
(Gallus gallus)
Aves BTBD10 36
  • 83.07 (n)
  • 94.78 (a)
BTBD10 37
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BTBD10 37
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4191 36
tropical clawed frog
(Silurana tropicalis)
Amphibia btbd10 36
  • 78.44 (n)
  • 90.79 (a)
Str.11032 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6042 36
zebrafish
(Danio rerio)
Actinopterygii btbd10b 36
  • 74.98 (n)
  • 88.94 (a)
btbd10b 37
  • 86 (a)
OneToOne
wufa12a08 36
fruit fly
(Drosophila melanogaster)
Insecta mri 37
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea snpc-1.4 37
  • 35 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2024 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5266 37
  • 47 (a)
OneToMany
Species with no ortholog for BTBD10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BTBD10 Gene

ENSEMBL:
Gene Tree for BTBD10 (if available)
TreeFam:
Gene Tree for BTBD10 (if available)

Paralogs for BTBD10 Gene

Paralogs for BTBD10 Gene

Selected SIMAP similar genes for BTBD10 Gene using alignment to 10 proteins:

Pseudogenes.org Pseudogenes for BTBD10 Gene

genes like me logo Genes that share paralogs with BTBD10: view

Variants for BTBD10 Gene

Sequence variations from dbSNP and Humsavar for BTBD10 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs307207 -- 13,454,178(-) ATTCT(C/T)TTAAG intron-variant
rs307243 -- 13,459,062(+) TATTT(A/T)TTTTT intron-variant
rs307244 -- 13,459,132(+) GCTCA(C/T)TGCAA intron-variant
rs307245 -- 13,460,452(+) ACTAG(G/T)TATGA intron-variant
rs307246 -- 13,461,680(+) GGTTA(A/G)AAGTC intron-variant

Relevant External Links for BTBD10 Gene

HapMap Linkage Disequilibrium report
BTBD10

No data available for Structural Variations from Database of Genomic Variants (DGV) for BTBD10 Gene

Disorders for BTBD10 Gene

(1) MalaCards Diseases for BTBD10 Gene

Search for BTBD10 Gene in MalaCards »

Relevant External Links for BTBD10

Genetic Association Database (GAD)
BTBD10
Human Genome Epidemiology (HuGE) Navigator
BTBD10
genes like me logo Genes that share disorders with BTBD10: view

No data available for UniProtKB/Swiss-Prot for BTBD10 Gene

Publications for BTBD10 Gene

  1. Molecular cloning and characterization of a novel human BTB domain- containing gene, BTBD10, which is down-regulated in glioma. (PMID: 15556295) Chen J. … Lu Y. (Gene 2004) 2 3 4 23
  2. Glucose metabolism-related protein 1 (GMRP1) regulates pancreatic beta cell proliferation and apoptosis via activation of Akt signalling pathway in rats and mice. (PMID: 21267538) Wang X. … Hu R. (Diabetologia 2011) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for BTBD10 Gene

Sources for BTBD10 Gene

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