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Aliases for BTBD10 Gene

Aliases for BTBD10 Gene

  • BTB Domain Containing 10 2 3
  • BTB (POZ) Domain Containing 10 2 3 5
  • Glucose Metabolism-Related Protein 1 3 4
  • GMRP1 3 4
  • BTB (Broad-Complex Tramtrack And Bric-A-Brac/Pox Virus And Zinc Finger) Domain-Containing Protein 10 3
  • K+ Channel Tetramerization Protein 3
  • GMRP-1 3

External Ids for BTBD10 Gene

Previous GeneCards Identifiers for BTBD10 Gene

  • GC11M013367
  • GC11M013089

Summaries for BTBD10 Gene

GeneCards Summary for BTBD10 Gene

BTBD10 (BTB Domain Containing 10) is a Protein Coding gene. An important paralog of this gene is KCTD20.

UniProtKB/Swiss-Prot for BTBD10 Gene

  • Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTBD10 Gene

Genomics for BTBD10 Gene

Regulatory Elements for BTBD10 Gene

Promoters for BTBD10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BTBD10 on UCSC Golden Path with GeneCards custom track

Genomic Location for BTBD10 Gene

Chromosome:
11
Start:
13,387,996 bp from pter
End:
13,463,297 bp from pter
Size:
75,302 bases
Orientation:
Minus strand

Genomic View for BTBD10 Gene

Genes around BTBD10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTBD10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTBD10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTBD10 Gene

Proteins for BTBD10 Gene

  • Protein details for BTBD10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSF8-BTBDA_HUMAN
    Recommended name:
    BTB/POZ domain-containing protein 10
    Protein Accession:
    Q9BSF8
    Secondary Accessions:
    • B7Z228
    • Q86WG1

    Protein attributes for BTBD10 Gene

    Size:
    475 amino acids
    Molecular mass:
    53779 Da
    Quaternary structure:
    • Interacts (via C-terminal 330-amino-acid region) with AKT1; AKT2 and AKT3. Interacts with PPP2CA and PPP1CA.

    Alternative splice isoforms for BTBD10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BTBD10 Gene

Proteomics data for BTBD10 Gene at MOPED

Post-translational modifications for BTBD10 Gene

  • Ubiquitination at Lys 157 and Lys 211
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for BTBD10 Gene

Domains & Families for BTBD10 Gene

Gene Families for BTBD10 Gene

Protein Domains for BTBD10 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9BSF8

UniProtKB/Swiss-Prot:

BTBDA_HUMAN :
  • Contains 1 BTB (POZ) domain.
Domain:
  • Contains 1 BTB (POZ) domain.
genes like me logo Genes that share domains with BTBD10: view

Function for BTBD10 Gene

Molecular function for BTBD10 Gene

UniProtKB/Swiss-Prot Function:
Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells.
genes like me logo Genes that share phenotypes with BTBD10: view

Animal Model Products

miRNA for BTBD10 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BTBD10 Gene

Localization for BTBD10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTBD10 Gene

Nucleus. Cytoplasm. Note=Colocalizes with KCTD20 in filamentous structures. {ECO:0000250 UniProtKB:Q80X66}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BTBD10 Gene COMPARTMENTS Subcellular localization image for BTBD10 gene
Compartment Confidence
nucleus 5
cytosol 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for BTBD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS,IDA --
genes like me logo Genes that share ontologies with BTBD10: view

Pathways & Interactions for BTBD10 Gene

SuperPathways for BTBD10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BTBD10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1901215 negative regulation of neuron death IEA,ISS --
genes like me logo Genes that share ontologies with BTBD10: view

No data available for Pathways by source and SIGNOR curated interactions for BTBD10 Gene

Drugs & Compounds for BTBD10 Gene

(3) Drugs for BTBD10 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with BTBD10: view

Transcripts for BTBD10 Gene

Unigene Clusters for BTBD10 Gene

BTB (POZ) domain containing 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BTBD10 Gene

No ASD Table

Relevant External Links for BTBD10 Gene

GeneLoc Exon Structure for
BTBD10
ECgene alternative splicing isoforms for
BTBD10

Expression for BTBD10 Gene

mRNA expression in normal human tissues for BTBD10 Gene

Protein differential expression in normal tissues from HIPED for BTBD10 Gene

This gene is overexpressed in Heart (68.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BTBD10 Gene



SOURCE GeneReport for Unigene cluster for BTBD10 Gene Hs.332382

mRNA Expression by UniProt/SwissProt for BTBD10 Gene

Q9BSF8-BTBDA_HUMAN
Tissue specificity: Ubiquitously expressed. Highly expressed in adult brain, testis, aorta and small intestine and weakly expressed in the heart, lung, liver, kidney, pancreas, spleen, thymus, prostate, ovary and colon. Down-regulated in glioma.
genes like me logo Genes that share expression patterns with BTBD10: view

Protein tissue co-expression partners for BTBD10 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for BTBD10 Gene

Orthologs for BTBD10 Gene

This gene was present in the common ancestor of animals.

Orthologs for BTBD10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BTBD10 35
  • 92.6 (n)
  • 97.09 (a)
BTBD10 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BTBD10 35
  • 95.02 (n)
  • 98.11 (a)
BTBD10 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Btbd10 35
  • 92.07 (n)
  • 97.26 (a)
Btbd10 16
Btbd10 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BTBD10 35
  • 99.86 (n)
  • 100 (a)
BTBD10 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Btbd10 35
  • 91.26 (n)
  • 97.42 (a)
oppossum
(Monodelphis domestica)
Mammalia BTBD10 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BTBD10 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves BTBD10 35
  • 83.07 (n)
  • 94.78 (a)
BTBD10 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BTBD10 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia btbd10 35
  • 78.44 (n)
  • 90.79 (a)
Str.11032 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.4191 35
zebrafish
(Danio rerio)
Actinopterygii btbd10b 35
  • 74.98 (n)
  • 88.94 (a)
wufa12a08 35
btbd10b 36
  • 86 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6042 35
fruit fly
(Drosophila melanogaster)
Insecta mri 36
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea snpc-1.4 36
  • 35 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2024 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5266 36
  • 47 (a)
OneToMany
Species with no ortholog for BTBD10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BTBD10 Gene

ENSEMBL:
Gene Tree for BTBD10 (if available)
TreeFam:
Gene Tree for BTBD10 (if available)

Paralogs for BTBD10 Gene

Paralogs for BTBD10 Gene

(1) SIMAP similar genes for BTBD10 Gene using alignment to 10 proteins:

Pseudogenes.org Pseudogenes for BTBD10 Gene

genes like me logo Genes that share paralogs with BTBD10: view

Variants for BTBD10 Gene

Sequence variations from dbSNP and Humsavar for BTBD10 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_033638 -
rs307207 -- 13,454,178(-) ATTCT(C/T)TTAAG intron-variant
rs307243 -- 13,459,062(+) TATTT(A/T)TTTTT intron-variant
rs307244 -- 13,459,132(+) GCTCA(C/T)TGCAA intron-variant
rs307245 -- 13,460,452(+) ACTAG(G/T)TATGA intron-variant, upstream-variant-2KB

Variation tolerance for BTBD10 Gene

Residual Variation Intolerance Score: 29.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BTBD10 Gene

HapMap Linkage Disequilibrium report
BTBD10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BTBD10 Gene

Disorders for BTBD10 Gene

Relevant External Links for BTBD10

Genetic Association Database (GAD)
BTBD10
Human Genome Epidemiology (HuGE) Navigator
BTBD10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BTBD10

No disorders were found for BTBD10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BTBD10 Gene

Publications for BTBD10 Gene

  1. Molecular cloning and characterization of a novel human BTB domain- containing gene, BTBD10, which is down-regulated in glioma. (PMID: 15556295) Chen J. … Lu Y. (Gene 2004) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Protein phosphatase 1I^ isoforms linked interactions in the brain. (PMID: 23080069) Esteves S.L. … da Cruz e Silva E.F. (J. Mol. Neurosci. 2013) 3
  4. Reduced expression of BTBD10 in anterior horn cells with Golgi fragmentation and pTDP-43-positive inclusions in patients with sporadic amyotrophic lateral sclerosis. (PMID: 23320755) Furuta N. … Okamoto K. (Neuropathology 2013) 3
  5. Protein phosphatase 1I+ interacting proteins in the human brain. (PMID: 22321011) Esteves S.L. … da Cruz e Silva E.F. (OMICS 2012) 3

Products for BTBD10 Gene

Sources for BTBD10 Gene

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