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Aliases for BTAF1 Gene

Aliases for BTAF1 Gene

  • BTAF1 RNA Polymerase II, B-TFIID Transcription Factor-Associated, 170kDa 2 3
  • TAF172 3 4 6
  • B-TFIID Transcription Factor-Associated 170 KDa Subunit 3 4
  • ATP-Dependent Helicase BTAF1 3 4
  • TBP-Associated Factor 172 3 4
  • TAF(II)170 3 4
  • TAFII170 3 6
  • MOT1 3 6
  • BTAF1 RNA Polymerase II, B-TFIID Transcription Factor-Associated, 170 KD (Mot1 Homolog, S. Cerevisiae) 2
  • BTAF1 RNA Polymerase II, B-TFIID Transcription Factor-Associated, 170kDa (Mot1 Homolog, S. Cerevisiae) 3
  • TATA-Binding Protein-Associated Factor 172 3
  • Mot1 Homolog (S. Cerevisiae) 2
  • Mot1 Homolog 3
  • EC 3.6.4.- 4
  • EC 3.6.1 63
  • TAF-172 4

External Ids for BTAF1 Gene

Summaries for BTAF1 Gene

Entrez Gene Summary for BTAF1 Gene

  • This gene encodes a TAF (TATA box-binding protein-associated factor), which associates with TBP (TATA box-binding protein) to form the B-TFIID complex that is required for transcription initiation of genes by RNA polymerase II. This TAF has DNA-dependent ATPase activity, which drives the dissociation of TBP from DNA, freeing the TBP to associate with other TATA boxes or TATA-less promoters. [provided by RefSeq, Sep 2011]

GeneCards Summary for BTAF1 Gene

BTAF1 (BTAF1 RNA Polymerase II, B-TFIID Transcription Factor-Associated, 170kDa) is a Protein Coding gene. Among its related pathways are Chromatin Regulation / Acetylation. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and helicase activity. An important paralog of this gene is ZRANB3.

UniProtKB/Swiss-Prot for BTAF1 Gene

  • Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box in an ATP-dependent manner

Gene Wiki entry for BTAF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTAF1 Gene

Genomics for BTAF1 Gene

Genomic Location for BTAF1 Gene

Start:
91,923,769 bp from pter
End:
92,030,998 bp from pter
Size:
107,230 bases
Orientation:
Plus strand

Genomic View for BTAF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BTAF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTAF1 Gene

Regulatory Elements for BTAF1 Gene

Proteins for BTAF1 Gene

  • Protein details for BTAF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14981-BTAF1_HUMAN
    Recommended name:
    TATA-binding protein-associated factor 172
    Protein Accession:
    O14981
    Secondary Accessions:
    • B4E0W6
    • O43578

    Protein attributes for BTAF1 Gene

    Size:
    1849 amino acids
    Molecular mass:
    206887 Da
    Quaternary structure:
    • Associates with TBP to form B-TFIID. Binds DRAP1

    Alternative splice isoforms for BTAF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BTAF1 Gene

Proteomics data for BTAF1 Gene at MOPED

Selected DME Specific Peptides for BTAF1 Gene

Post-translational modifications for BTAF1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys430

Other Protein References for BTAF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for BTAF1 Gene

Graphical View of Domain Structure for InterPro Entry

O14981

UniProtKB/Swiss-Prot:

BTAF1_HUMAN
Domain:
  • Contains 1 helicase ATP-binding domain.:
    • O14981
  • Contains 1 helicase C-terminal domain.:
    • O14981
Family:
  • Belongs to the SNF2/RAD54 helicase family.:
    • O14981
Similarity:
  • Contains 8 HEAT repeats.:
    • O14981
genes like me logo Genes that share domains with BTAF1: view

No data available for Gene Families for BTAF1 Gene

Function for BTAF1 Gene

Molecular function for BTAF1 Gene

UniProtKB/Swiss-Prot Function: Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box in an ATP-dependent manner

Enzyme Numbers (IUBMB) for BTAF1 Gene

Gene Ontology (GO) - Molecular Function for BTAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 9342322
GO:0004386 helicase activity IEA --
GO:0005488 binding --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with BTAF1: view
genes like me logo Genes that share phenotypes with BTAF1: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for BTAF1 Gene

Localization for BTAF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTAF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BTAF1 Gene COMPARTMENTS Subcellular localization image for BTAF1 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BTAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with BTAF1: view

Pathways for BTAF1 Gene

genes like me logo Genes that share pathways with BTAF1: view

Pathways by source for BTAF1 Gene

1 Cell Signaling Technology pathway for BTAF1 Gene

Gene Ontology (GO) - Biological Process for BTAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0035562 negative regulation of chromatin binding IMP 23361013
GO:0045892 negative regulation of transcription, DNA-templated NAS 9488487
genes like me logo Genes that share ontologies with BTAF1: view

Compounds for BTAF1 Gene

(1) Novoseek inferred chemical compound relationships for BTAF1 Gene

Compound -log(P) Hits PubMed IDs
atp 33.9 8
genes like me logo Genes that share compounds with BTAF1: view

Transcripts for BTAF1 Gene

Unigene Clusters for BTAF1 Gene

BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BTAF1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18a ·
SP1: - - -
SP2:
SP3: -
SP4:
SP5: -
SP6:
SP7:

ExUns: 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40a · 40b
SP1: - -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for BTAF1 Gene

GeneLoc Exon Structure for
BTAF1
ECgene alternative splicing isoforms for
BTAF1

Expression for BTAF1 Gene

mRNA expression in normal human tissues for BTAF1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BTAF1 Gene

SOURCE GeneReport for Unigene cluster for BTAF1 Gene Hs.500526

genes like me logo Genes that share expressions with BTAF1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BTAF1 Gene

Orthologs for BTAF1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BTAF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BTAF1 35
  • 99.8 (n)
  • 100 (a)
BTAF1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BTAF1 35
  • 92.92 (n)
  • 96.62 (a)
BTAF1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BTAF1 35
  • 94.54 (n)
  • 98.22 (a)
BTAF1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Btaf1 35
  • 91.45 (n)
  • 96.32 (a)
Btaf1 16
Btaf1 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BTAF1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BTAF1 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Btaf1 35
  • 90.41 (n)
  • 96.58 (a)
chicken
(Gallus gallus)
Aves BTAF1 35
  • 82.06 (n)
  • 90.15 (a)
BTAF1 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BTAF1 36
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3882 35
tropical clawed frog
(Silurana tropicalis)
Amphibia btaf1 35
  • 74.8 (n)
  • 83.49 (a)
Str.10370 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10833 35
zebrafish
(Danio rerio)
Actinopterygii btaf1 35
btaf1 35
  • 69.09 (n)
  • 78.74 (a)
btaf1 36
  • 78 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001820 35
  • 50.36 (n)
  • 50.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hel89B 35
  • 52.39 (n)
  • 49.83 (a)
Hel89B 36
  • 46 (a)
OneToOne
Hel89B 37
  • 58 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL256C 35
  • 48.41 (n)
  • 40.94 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOT1 35
  • 50.71 (n)
  • 41.65 (a)
MOT1 36
  • 38 (a)
OneToMany
MOT1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E23717g 35
  • 49.79 (n)
  • 42.35 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RGD3 35
  • 51.58 (n)
  • 45.26 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.8874 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07556 35
  • 48.81 (n)
  • 43.2 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mot1 35
  • 52.61 (n)
  • 45.24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10805 36
  • 42 (a)
OneToOne
Species with no ortholog for BTAF1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BTAF1 Gene

ENSEMBL:
Gene Tree for BTAF1 (if available)
TreeFam:
Gene Tree for BTAF1 (if available)

Paralogs for BTAF1 Gene

Paralogs for BTAF1 Gene

Selected SIMAP similar genes for BTAF1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with BTAF1: view

Variants for BTAF1 Gene

Sequence variations from dbSNP and Humsavar for BTAF1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1437 -- 92,030,766(-) TCAGC(C/T)CTGAC downstream-variant-500B, utr-variant-3-prime
rs15867 -- 91,997,622(+) NTAGA(A/T)GTTGG missense, reference, nc-transcript-variant
rs833366 -- 92,022,903(-) TTATA(C/T)AGTAG intron-variant
rs833367 -- 92,022,788(-) TTCTT(C/T)TAAAA intron-variant
rs833368 -- 92,022,169(-) TTGAC(A/G)TAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BTAF1 Gene

Variant ID Type Subtype PubMed ID
nsv895893 CNV Gain 21882294

Relevant External Links for BTAF1 Gene

HapMap Linkage Disequilibrium report
BTAF1
Human Gene Mutation Database (HGMD)
BTAF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTAF1 Gene

Disorders for BTAF1 Gene

Relevant External Links for BTAF1

Genetic Association Database (GAD)
BTAF1
Human Genome Epidemiology (HuGE) Navigator
BTAF1
genes like me logo Genes that share disorders with BTAF1: view

No data available for UniProtKB/Swiss-Prot for BTAF1 Gene

Publications for BTAF1 Gene

  1. Cloning of the cDNA for the TATA-binding protein-associated factorII170 subunit of transcription factor B-TFIID reveals homology to global transcription regulators in yeast and Drosophila. (PMID: 9342322) van der Knaap J.A. … Timmers H.T.M. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 23
  2. Cloning and biochemical characterization of TAF-172, a human homolog of yeast Mot1. (PMID: 9488487) Chicca J.J. II … Pugh B.F. (Mol. Cell. Biol. 1998) 2 3 4 23
  3. NC2alpha interacts with BTAF1 and stimulates its ATP-dependent association with TATA-binding protein. (PMID: 15509807) Klejman M.P. … Timmers H.T.M. (Mol. Cell. Biol. 2004) 3 4 23
  4. The gene for human TATA-binding-protein-associated factor (TAFII) 170: structure, promoter and chromosomal localization. (PMID: 10642510) Van Der Knaap J.A. … Timmers H.T.M. (Biochem. J. 2000) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for BTAF1 Gene

Sources for BTAF1 Gene

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