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Aliases for BTAF1 Gene

Aliases for BTAF1 Gene

  • B-TFIID TATA-Box Binding Protein Associated Factor 1 2 3 5
  • B-TFIID Transcription Factor-Associated 170 KDa Subunit 3 4
  • ATP-Dependent Helicase BTAF1 3 4
  • TBP-Associated Factor 172 3 4
  • TAF(II)170 3 4
  • TAF172 3 4
  • BTAF1 RNA Polymerase II, B-TFIID Transcription Factor-Associated, 170 KD (Mot1 Homolog, S. Cerevisiae) 2
  • BTAF1 RNA Polymerase II, B-TFIID Transcription Factor-Associated, 170kDa (Mot1 Homolog, S. Cerevisiae) 3
  • BTAF1 RNA Polymerase II, B-TFIID Transcription Factor-Associated, 170kDa 2
  • Mot1 Homolog (S. Cerevisiae) 2
  • Mot1 Homolog 3
  • EC 3.6.4.- 4
  • TAFII170 3
  • EC 3.6.1 63
  • TAF-172 4
  • MOT1 3

External Ids for BTAF1 Gene

Previous GeneCards Identifiers for BTAF1 Gene

  • GC10P092564
  • GC10P092905
  • GC10P093814
  • GC10P093348
  • GC10P093338
  • GC10P093673
  • GC10P087312

Summaries for BTAF1 Gene

Entrez Gene Summary for BTAF1 Gene

  • This gene encodes a TAF (TATA box-binding protein-associated factor), which associates with TBP (TATA box-binding protein) to form the B-TFIID complex that is required for transcription initiation of genes by RNA polymerase II. This TAF has DNA-dependent ATPase activity, which drives the dissociation of TBP from DNA, freeing the TBP to associate with other TATA boxes or TATA-less promoters. [provided by RefSeq, Sep 2011]

GeneCards Summary for BTAF1 Gene

BTAF1 (B-TFIID TATA-Box Binding Protein Associated Factor 1) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and helicase activity. An important paralog of this gene is ZRANB3.

UniProtKB/Swiss-Prot for BTAF1 Gene

  • Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box in an ATP-dependent manner.

Gene Wiki entry for BTAF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTAF1 Gene

Genomics for BTAF1 Gene

Regulatory Elements for BTAF1 Gene

Promoters for BTAF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BTAF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for BTAF1 Gene

Chromosome:
10
Start:
91,923,769 bp from pter
End:
92,030,998 bp from pter
Size:
107,230 bases
Orientation:
Plus strand

Genomic View for BTAF1 Gene

Genes around BTAF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BTAF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BTAF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BTAF1 Gene

Proteins for BTAF1 Gene

  • Protein details for BTAF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14981-BTAF1_HUMAN
    Recommended name:
    TATA-binding protein-associated factor 172
    Protein Accession:
    O14981
    Secondary Accessions:
    • B4E0W6
    • O43578

    Protein attributes for BTAF1 Gene

    Size:
    1849 amino acids
    Molecular mass:
    206887 Da
    Quaternary structure:
    • Associates with TBP to form B-TFIID. Binds DRAP1.

    Alternative splice isoforms for BTAF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BTAF1 Gene

Proteomics data for BTAF1 Gene at MOPED

Selected DME Specific Peptides for BTAF1 Gene

Post-translational modifications for BTAF1 Gene

  • Ubiquitination at Lys 430
  • Modification sites at PhosphoSitePlus

Other Protein References for BTAF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for BTAF1 (TAF172)

Domains & Families for BTAF1 Gene

Graphical View of Domain Structure for InterPro Entry

O14981

UniProtKB/Swiss-Prot:

BTAF1_HUMAN :
  • Contains 1 helicase ATP-binding domain.
  • Belongs to the SNF2/RAD54 helicase family.
  • Contains 8 HEAT repeats.
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the SNF2/RAD54 helicase family.
Similarity:
  • Contains 8 HEAT repeats.
genes like me logo Genes that share domains with BTAF1: view

No data available for Gene Families for BTAF1 Gene

Function for BTAF1 Gene

Molecular function for BTAF1 Gene

UniProtKB/Swiss-Prot Function:
Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box in an ATP-dependent manner.

Enzyme Numbers (IUBMB) for BTAF1 Gene

Gene Ontology (GO) - Molecular Function for BTAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005488 binding IEA --
genes like me logo Genes that share ontologies with BTAF1: view
genes like me logo Genes that share phenotypes with BTAF1: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BTAF1 Gene

Localization for BTAF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTAF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BTAF1 Gene COMPARTMENTS Subcellular localization image for BTAF1 gene
Compartment Confidence
nucleus 5
plasma membrane 3
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for BTAF1 Gene

Pathways & Interactions for BTAF1 Gene

SuperPathways for BTAF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BTAF1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BTAF1 Gene

Drugs & Compounds for BTAF1 Gene

(1) Drugs for BTAF1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with BTAF1: view

Transcripts for BTAF1 Gene

Unigene Clusters for BTAF1 Gene

BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BTAF1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18a ·
SP1: - - -
SP2:
SP3: -
SP4:
SP5: -
SP6:
SP7:

ExUns: 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40a · 40b
SP1: - -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for BTAF1 Gene

GeneLoc Exon Structure for
BTAF1
ECgene alternative splicing isoforms for
BTAF1

Expression for BTAF1 Gene

mRNA expression in normal human tissues for BTAF1 Gene

Protein differential expression in normal tissues from HIPED for BTAF1 Gene

This gene is overexpressed in Serum (30.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BTAF1 Gene



SOURCE GeneReport for Unigene cluster for BTAF1 Gene Hs.500526

genes like me logo Genes that share expression patterns with BTAF1: view

Protein tissue co-expression partners for BTAF1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BTAF1 Gene

Orthologs for BTAF1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BTAF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BTAF1 35
  • 92.92 (n)
  • 96.62 (a)
BTAF1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BTAF1 35
  • 94.54 (n)
  • 98.22 (a)
BTAF1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Btaf1 35
  • 91.45 (n)
  • 96.32 (a)
Btaf1 16
Btaf1 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BTAF1 35
  • 99.8 (n)
  • 100 (a)
BTAF1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Btaf1 35
  • 90.41 (n)
  • 96.58 (a)
oppossum
(Monodelphis domestica)
Mammalia BTAF1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BTAF1 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves BTAF1 35
  • 82.06 (n)
  • 90.15 (a)
BTAF1 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BTAF1 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia btaf1 35
  • 74.8 (n)
  • 83.49 (a)
Str.10370 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.3882 35
zebrafish
(Danio rerio)
Actinopterygii btaf1 35
btaf1 35
  • 69.09 (n)
  • 78.74 (a)
btaf1 36
  • 78 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10833 35
fruit fly
(Drosophila melanogaster)
Insecta Hel89B 37
  • 58 (a)
Hel89B 35
  • 52.39 (n)
  • 49.83 (a)
Hel89B 36
  • 46 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001820 35
  • 50.36 (n)
  • 50.19 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL256C 35
  • 48.41 (n)
  • 40.94 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E23717g 35
  • 49.79 (n)
  • 42.35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOT1 35
  • 50.71 (n)
  • 41.65 (a)
MOT1 36
  • 38 (a)
OneToMany
MOT1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons RGD3 35
  • 51.58 (n)
  • 45.26 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.8874 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07556 35
  • 48.81 (n)
  • 43.2 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mot1 35
  • 52.61 (n)
  • 45.24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10805 36
  • 42 (a)
OneToOne
Species with no ortholog for BTAF1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BTAF1 Gene

ENSEMBL:
Gene Tree for BTAF1 (if available)
TreeFam:
Gene Tree for BTAF1 (if available)

Paralogs for BTAF1 Gene

Paralogs for BTAF1 Gene

(6) SIMAP similar genes for BTAF1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with BTAF1: view

Variants for BTAF1 Gene

Sequence variations from dbSNP and Humsavar for BTAF1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1437 -- 92,030,766(-) TCAGC(C/T)CTGAC downstream-variant-500B, utr-variant-3-prime
rs15867 -- 91,997,622(+) NTAGA(A/T)GTTGG nc-transcript-variant, reference, missense
rs1136716 -- 91,996,553(+) GGGTG(C/T)AATTG nc-transcript-variant, downstream-variant-500B, reference, missense
rs1136717 -- 91,997,617(+) AACAA(C/T)TAGAT nc-transcript-variant, reference, synonymous-codon
rs1137823 -- 91,947,635(-) ctcat(A/G)catct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BTAF1 Gene

Variant ID Type Subtype PubMed ID
nsv895893 CNV Gain 21882294

Variation tolerance for BTAF1 Gene

Residual Variation Intolerance Score: 1.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.24; 40.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BTAF1 Gene

HapMap Linkage Disequilibrium report
BTAF1
Human Gene Mutation Database (HGMD)
BTAF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTAF1 Gene

Disorders for BTAF1 Gene

Relevant External Links for BTAF1

Genetic Association Database (GAD)
BTAF1
Human Genome Epidemiology (HuGE) Navigator
BTAF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BTAF1

No disorders were found for BTAF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BTAF1 Gene

Publications for BTAF1 Gene

  1. Cloning and biochemical characterization of TAF-172, a human homolog of yeast Mot1. (PMID: 9488487) Chicca J.J. II … Pugh B.F. (Mol. Cell. Biol. 1998) 2 3 4 23 67
  2. Cloning of the cDNA for the TATA-binding protein-associated factorII170 subunit of transcription factor B-TFIID reveals homology to global transcription regulators in yeast and Drosophila. (PMID: 9342322) van der Knaap J.A. … Timmers H.T.M. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 23
  3. NC2alpha interacts with BTAF1 and stimulates its ATP-dependent association with TATA-binding protein. (PMID: 15509807) Klejman M.P. … Timmers H.T.M. (Mol. Cell. Biol. 2004) 3 23
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for BTAF1 Gene

Sources for BTAF1 Gene

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