BSX Gene
protein-coding GIFtS: 37
GCID: GC11M122848
|
|
brain-specific homeobox
| |
Aliases
for BSX gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Brain-Specific Homeobox1 2 | | BSX11 2 3 5 | | Brain Specific Homeobox2 | | Brain-Specific Homeobox Protein Homolog2 |
Export aliases for BSX gene to outside databasesPrevious GC identifers: GC11M122354 GC11M118791 |
Summaries
for BSX gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: BSH_HUMAN, Q3C1V8Function: DNA binding protein that function as transcriptional activator. Is essentiel for normal postnatal growth andnursing. Is an essential factor for neuronal neuropeptide Y and agouti-related peptide function and locomotorybehavior in the control of energy balance (By similarity)
|
Genomic Views
for BSX gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BSX gene promoter:
E2F-4 E2F-3a E2F-5 Sp1 NRSF form 1 E2F-2 NRSF form 2 HEN1 E2F E2F-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for BSX
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BSX |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q24.1 Ensembl cytogenetic band: 11q24.1 HGNC cytogenetic band: 11q24.1BSX Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M122848: view genomic region
(about GC identifiers)
Start:
|
122,848,278 bp from pter |
End:
|
122,852,428 bp from pter |
Size:
|
4,151 bases |
Orientation:
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minus strand |
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Proteins
for BSX gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BSH_HUMAN, Q3C1V8 (See
protein sequence)Recommended Name: Brain-specific homeobox protein homolog Size: 233 amino acids; 25933 Da
Subcellular location: Nucleus (By similarity)Explore the universe of human proteins at neXtProt for BSX: NX_Q3C1V8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q3C1V8
BSX Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001091639.1
ENSEMBL proteins: ENSP00000344285
Human Recombinant Protein Products for BSX:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
BSX for ontologies About GeneDecksing
BSX Antibody Products:
Assay Products for BSX: |
Protein
Domains /
Families
for BSX gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BSX for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q3C1V8ProtoNet protein and cluster: Q3C1V8 UniProtKB/Swiss-Prot: BSH_HUMAN, Q3C1V8Similarity: Belongs to the distal-less homeobox familySimilarity: Contains 1 homeobox DNA-binding domain |
Function
for BSX gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: BSH_HUMAN, Q3C1V8Function: DNA binding protein that function as transcriptional activator. Is essentiel for normal postnatal growth andnursing. Is an essential factor for neuronal neuropeptide Y and agouti-related peptide function and locomotorybehavior in the control of energy balance (By similarity) Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0005515 | protein binding |
-- | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- |
BSX for ontologies About GeneDecksing
Phenotypes:
10 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Bsx):
BSX for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Bsxtm1Aoh for BSX
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BSX (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BSX
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: BSX (NM_001098169) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BSX | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat BSX |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BSX |
|
Pathways & Interactions
for BSX gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BSX
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0007626 | locomotory behavior |
IEA | -- | | GO:0042755 | eating behavior |
IEA | -- | | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter |
IEA | -- | | GO:0060056 | mammary gland involution |
IEA | -- |
BSX for ontologies About GeneDecksing
|
Drugs & Compounds
for BSX gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BSX
Search CenterWatch for drugs/clinical trials and news about BSX / BSH
|
Transcripts
for BSX gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BSX gene: NM_001098169.1 Unigene Cluster for BSX: Brain-specific homeobox Hs.449687 [show with all ESTs]Unigene Representative Sequence: NM_0010981691 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000343035(uc010rzs.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BSX (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BSX
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: BSX (NM_001098169) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BSX | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat BSX |
Additional cDNA sequence: AB231738.1 1 DOTS entry: DT.120713688
GeneLoc Exon Structure
|
Expression
for BSX gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BSX expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCACACCCA
About this image
See BSX Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.449687
SABiosciences Custom PCR Arrays for BSX
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BSX
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BSX | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BSX | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BSX | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BSX |
Orthologs
for BSX gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for BSX gene from 5/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
BSX1 |
brain-specific homeobox |
76.33(n)
78.79(a) |
|
395183 NM_204512.1 NP_989843.1 |
lizard
(Anolis carolinensis) |
Reptilia |
BSX6 |
-- |
79(a) |
1 ↔ 1 |
LGa(2979353-2985980) |
zebrafish
(Danio rerio) |
Actinopterygii |
bsx1 |
brain specific homeobox |
66.21(n)
71.1(a) |
|
573364 NM_214727.1 NP_999892.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
bsh6 |
brain-specific homeobox |
19(a) |
1 ↔ 1 |
2L(19765776-19769067) |
worm
(Caenorhabditis elegans) |
Secernentea |
tab-16 |
Touch ABnormal family member (tab-1) |
34(a) |
1 ↔ 1 |
II(6803715-6804820) |
ENSEMBL Gene Tree for BSX (if available)
TreeFam Gene Tree for BSX (if available) |
Paralogs
for BSX gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BSX gene
- DLX22 BARX12 DLX52 DLX62 BARHL22 BARHL12 DLX42 BARX22
- DLX12 MSX22 MSX12 DLX32
1 SIMAP similar gene for BSX using alignment to 1 protein entry: BSH_HUMAN:MNX1
BSX for paralogs About GeneDecksing
|
Genomic Variants
for BSX gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BSX (122848278 - 122852428 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for BSX
1 CNV: 2959 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BSX |
|
Disorders
/ Diseases
for BSX gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BSX for disorders About GeneDecksing
OMIM gene information: 611074
OMIM disorders: --
3  diseases for BSX: About MalaCardsjacobsen syndrome glomerulonephritis neuronitis
Human Genome Epidemiology (HuGE) Navigator: BSX (1 document)
Export disorders for BSX gene to outside databases
|
Publications
for BSX gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BSX gene integrated from 9 sources:
(articles sorted by number of sources associating them with BSX) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Thirty new loci for age at menarche identified by a m eta-analysis of genome-wide association studies. (PubMed id 21102462)1 Elks C.E....Murray A. (2010)
- Chromosomal microarray mapping suggests a role for BSX and Neurogranin in neurocognitive and behavioral defects in the 11q terminal deletion disorder (Jacobsen syndrome). (PubMed id 18855024)1 Coldren C.D....Grossfeld P.D. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Cloning and functional analysis of hypothalamic homeobox gene Bsx1a and its isoform, Bsx1b. (PubMed id 17353277)1 Chu H.Y. and Ohtoshi A. (2007)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
- Bsx, an evolutionary conserved Brain Specific homeoboX gene expressed in the septum, epiphysis, mammillary bodies and arcuate nucleus. (PubMed id 14678827)1 Cremona M....Broccoli V. (2004)
|
External Searches for BSX gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing BSX gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BSX gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BSX gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for BSX | Pharmacogenomics, SNPs, Pathways | | Protein Spotlight | http://web.expasy.org/spotlight/back_issues/sptlt085.shtml |
|
| | |
About This Section
| Patent Information for BSX gene:
Search GeneIP for patents involving BSX
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BSX gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for BSX | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BSX | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BSX | | | OriGene Protein Over-expression Lysate for BSX | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BSX | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BSX | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BSX | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BSX | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BSX | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BSX | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BSX | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BSX | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BSX |
| |
 |  |  |  | |
| | | | Search Tocris compounds for BSX |
| |  |  |  |  | | | | |
 |
 |
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 | | | BSX Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BSX |
|  |  |  |  | | | | Search ThermoFisher Antibodies for BSX |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat BSX |
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