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Aliases for BSX Gene

Aliases for BSX Gene

  • Brain-Specific Homeobox 2 3
  • BSX1 3 4 6
  • Brain-Specific Homeobox Protein Homolog 3
  • Brain Specific Homeobox 3

External Ids for BSX Gene

Previous GeneCards Identifiers for BSX Gene

  • GC11M122354
  • GC11M122848
  • GC11M118791

Summaries for BSX Gene

GeneCards Summary for BSX Gene

BSX (Brain-Specific Homeobox) is a Protein Coding gene. Diseases associated with BSX include jacobsen syndrome. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is DLX5.

UniProtKB/Swiss-Prot for BSX Gene

  • DNA binding protein that function as transcriptional activator. Is essentiel for normal postnatal growth and nursing. Is an essential factor for neuronal neuropeptide Y and agouti-related peptide function and locomotory behavior in the control of energy balance (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BSX Gene

Genomics for BSX Gene

Regulatory Elements for BSX Gene

Genomic Location for BSX Gene

Start:
122,977,570 bp from pter
End:
122,981,720 bp from pter
Size:
4,151 bases
Orientation:
Minus strand

Genomic View for BSX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BSX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BSX Gene

Proteins for BSX Gene

  • Protein details for BSX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3C1V8-BSH_HUMAN
    Recommended name:
    Brain-specific homeobox protein homolog
    Protein Accession:
    Q3C1V8
    Secondary Accessions:

    Protein attributes for BSX Gene

    Size:
    233 amino acids
    Molecular mass:
    25933 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BSX Gene

Proteomics data for BSX Gene at MOPED

Post-translational modifications for BSX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BSX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BSX Gene

Domains for BSX Gene

Gene Families for BSX Gene

HGNC:
  • NKL :Homeoboxes / ANTP class : NKL subclass

Protein Domains for BSX Gene

Suggested Antigen Peptide Sequences for BSX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3C1V8

UniProtKB/Swiss-Prot:

BSH_HUMAN :
  • Q3C1V8
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the distal-less homeobox family.
genes like me logo Genes that share domains with BSX: view

Function for BSX Gene

Molecular function for BSX Gene

UniProtKB/Swiss-Prot Function: DNA binding protein that function as transcriptional activator. Is essentiel for normal postnatal growth and nursing. Is an essential factor for neuronal neuropeptide Y and agouti-related peptide function and locomotory behavior in the control of energy balance (By similarity).

Gene Ontology (GO) - Molecular Function for BSX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with BSX: view
genes like me logo Genes that share phenotypes with BSX: view

Animal Models for BSX Gene

MGI Knock Outs for BSX:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for BSX Gene

Localization for BSX Gene

Subcellular locations from UniProtKB/Swiss-Prot for BSX Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BSX Gene COMPARTMENTS Subcellular localization image for BSX gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for BSX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005667 transcription factor complex IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with BSX: view

Pathways for BSX Gene

SuperPathways for BSX Gene

No Data Available

Interacting Proteins for BSX Gene

Gene Ontology (GO) - Biological Process for BSX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0007626 locomotory behavior IEA --
GO:0042755 eating behavior IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
GO:0060056 mammary gland involution IEA --
genes like me logo Genes that share ontologies with BSX: view

No data available for Pathways by source for BSX Gene

Transcripts for BSX Gene

mRNA/cDNA for BSX Gene

(1) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BSX Gene

Brain-specific homeobox:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BSX Gene

No ASD Table

Relevant External Links for BSX Gene

GeneLoc Exon Structure for
BSX
ECgene alternative splicing isoforms for
BSX

Expression for BSX Gene

mRNA expression in normal human tissues for BSX Gene

mRNA differential expression in normal tissues according to GTEx for BSX Gene

This gene is overexpressed in Brain - Hypothalamus (37.5) and Testis (11.0).

SOURCE GeneReport for Unigene cluster for BSX Gene Hs.449687

genes like me logo Genes that share expressions with BSX: view

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for BSX Gene

Orthologs for BSX Gene

This gene was present in the common ancestor of animals.

Orthologs for BSX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BSX 35
  • 99.71 (n)
  • 99.57 (a)
BSX 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BSX 35
  • 92.39 (n)
  • 95.69 (a)
BSX 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BSX 35
  • 92.24 (n)
  • 96.98 (a)
BSX 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bsx 35
  • 88.94 (n)
  • 96.12 (a)
Bsx 16
Bsx 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BSX 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BSX 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bsx 35
  • 87.5 (n)
  • 94.83 (a)
chicken
(Gallus gallus)
Aves BSX 35
  • 76.33 (n)
  • 78.79 (a)
BSX 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BSX 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bsx 35
  • 67.42 (n)
  • 77.83 (a)
zebrafish
(Danio rerio)
Actinopterygii bsx 35
  • 65.49 (n)
  • 69.91 (a)
bsx 36
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta bsh 36
  • 26 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tab-1 36
  • 41 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToOne
Species with no ortholog for BSX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BSX Gene

ENSEMBL:
Gene Tree for BSX (if available)
TreeFam:
Gene Tree for BSX (if available)

Paralogs for BSX Gene

Selected SIMAP similar genes for BSX Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BSX: view

Variants for BSX Gene

Sequence variations from dbSNP and Humsavar for BSX Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1381246 -- 122,978,266(+) CTCCG(C/G)GTTCT intron-variant
rs1870761 -- 122,980,855(+) CCTAC(A/C)CCCCT intron-variant
rs3057446 -- 122,979,631(-) TTTTT(-/TT)CTTCC intron-variant
rs7925206 -- 122,978,806(+) ttttt(C/T)ttttt intron-variant
rs7939002 -- 122,979,108(+) CAGGT(A/G)TAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BSX Gene

Variant ID Type Subtype PubMed ID
dgv442e1 CNV Complex 17122850

Relevant External Links for BSX Gene

HapMap Linkage Disequilibrium report
BSX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BSX Gene

Disorders for BSX Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for BSX Gene including...

Search for BSX Gene in MalaCards »

Relevant External Links for BSX

Genetic Association Database (GAD)
BSX
Human Genome Epidemiology (HuGE) Navigator
BSX
genes like me logo Genes that share disorders with BSX: view

No data available for UniProtKB/Swiss-Prot for BSX Gene

Publications for BSX Gene

  1. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PMID: 21102462) Elks C.E. … Murray A. (Nat. Genet. 2010) 3 48
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4
  3. Bsx, an evolutionary conserved Brain Specific homeoboX gene expressed in the septum, epiphysis, mammillary bodies and arcuate nucleus. (PMID: 14678827) Cremona M. … Broccoli V. (Gene Expr. Patterns 2004) 3
  4. Cloning and functional analysis of hypothalamic homeobox gene Bsx1a and its isoform, Bsx1b. (PMID: 17353277) Chu H.Y. … Ohtoshi A. (Mol. Cell. Biol. 2007) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for BSX Gene

Sources for BSX Gene

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