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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BST2 Gene

protein-coding   GIFtS: 59
GCID: GC19M017513

Bone Marrow Stromal Cell Antigen 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Bone Marrow Stromal Cell Antigen 21 2     TETHERIN2
BST-22 3     Bone Marrow Stromal Antigen 22
HM1.24 Antigen2 3     Tetherin3
CD3172     CD317 Antigen3
NPC-A-72     

External Ids:    HGNC: 11191   Entrez Gene: 6842   Ensembl: ENSG000001303037   OMIM: 6005345   UniProtKB: Q105893   

Export aliases for BST2 gene to outside databases

Previous GC identifers: GC19M018007 GC19M017906 GC19M017358 GC19M017374 GC19M017502 GC19M017080


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BST2 Gene:
Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the
protein encoded by the bone marrow stromal cell antigen 2 is undetermined; however, this protein may play a role
in pre-B-cell growth and in rheumatoid arthritis. (provided by RefSeq, Jul 2008)

GeneCards Summary for BST2 Gene: 
BST2 (bone marrow stromal cell antigen 2) is a protein-coding gene. Diseases associated with BST2 include west nile encephalitis, and megakaryocytic leukemia. GO annotations related to this gene include metalloendopeptidase inhibitor activity and protein homodimerization activity.

UniProtKB/Swiss-Prot: BST2_HUMAN, Q10589
Function: IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian
enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct
physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can
be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case,
their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including
retroviridae: human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), simian
immunodeficiency viruses (SIVs), equine infectious anemia virus (EIAV), feline immunodeficiency virus (FIV),
prototype foamy virus (PFV), Mason-Pfizer monkey virus (MPMV), human T-cell leukemia virus type 1 (HTLV-1), Rous
sarcoma virus (RSV) and murine leukemia virus (MLV), flavivirideae: hepatitis C virus (HCV), filoviridae: ebola
virus (EBOV) and marburg virus (MARV), arenaviridae: lassa virus (LASV) and machupo virus (MACV), herpesviridae:
kaposis sarcoma-associated herpesvirus (KSHV), rhabdoviridae: vesicular stomatitis virus (VSV), orthomyxoviridae:
influenza A virus, and paramyxoviridae: nipah virus. Can inhibit cell surface proteolytic activity of MMP14
causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate
signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid
dendritic cells in response to viral infection. Plays a role in the organization of the subapical actin
cytoskeleton in polarized epithelial cells

Gene Wiki entry for BST2 (Tetherin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BST2 gene promoter:
         STAT1   AP-1   ATF-2   STAT1beta   CUTL1   STAT1alpha   PPAR-gamma1   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): BST2 promoter sequence
   Search SABiosciences Chromatin IP Primers for BST2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BST2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.2

BST2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BST2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M017513:  view genomic region     (about GC identifiers)

Start:
17,513,748 bp from pter      End:
17,516,457 bp from pter
Size:
2,710 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BST2_HUMAN, Q10589 (See protein sequence)
Recommended Name: Bone marrow stromal antigen 2 precursor  
Size: 180 amino acids; 19769 Da
Subunit: Parallel homodimer; disulfide-linked. May form homotetramers under reducing conditions. Dimerization is
essential for its antiviral activity. Interacts (via cytoplasmic domain) with ARHGAP44 (By similarity). Interacts
with MMP14 (via C-terminal cytoplasmic tail). Interacts with LILRA4/ILT7. Interacts (via transmembrane domain)
with HIV-1 VPU (via transmembrane domain). Interacts with HIV-2 ENV and ebola GP protein
Subcellular location: Golgi apparatus, trans-Golgi network. Cell membrane; Single-pass type II membrane protein.
Cell membrane; Lipid-anchor, GPI-anchor. Late endosome. Membrane raft. Cytoplasm. Apical cell membrane (By
similarity). Note=Shuttles between the cell membrane, where it is present predominantly in membrane/lipid rafts,
and the trans-Golgi network. HIV-1 VPU and HIV-2 ENV can target it to the trans-Golgi network thus sequestering
it away from virus assembly sites on the cell membrane. Targeted to late endosomes upon KSHV infection and
subsequent ubiquitination. Forms a complex with MMP14 and localizes to the cytoplasm
Miscellaneous: Tetherin shows evidence of positive (adaptive) selection, presumably as a result of evolutionary
pressure applied by antagonistic viral proteins that counteract its inhibitiory activity and this has led to the
species-specific tetherin sensitivity to viral countermeasures. For example, Tantalus monkey tetherin cannot be
abrogated by HIV-1 VPU due to variation in the tetherin transmembrane region. Similarly, SIV Nefs are able to
overcome simian tetherins, but not human tetherin, due to a unique 5-amino-acid deletion in the cytoplasmic tail
domain of human tetherin (PubMed:19917491)
6/8 PDB 3D structures from and Proteopedia for BST2 (see all 8):
2LK9 (3D)        2X7A (3D)        2XG7 (3D)        3MQ7 (3D)        3MQ9 (3D)        3MQB (3D)    
Secondary accessions: A8K4Y4 Q53G07

Explore the universe of human proteins at neXtProt for BST2: NX_Q10589

Explore proteomics data for BST2 at MOPED 

Post-translational modifications:

  • UniProtKB: Monoubiquitinated by KSHV E3 ubiquitin-protein ligase K5, leading to its targeting to late endosomes and
    degradation
  • UniProtKB: The GPI anchor is essential for its antiviral activity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q10589

  • BST2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BST2 Protein Expression
    REFSEQ proteins: NP_004326.1  
    ENSEMBL proteins: 
     ENSP00000252593  

    Human Recombinant Protein Products for BST2: 
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    Novus Biologicals BST2 Proteins
    Novus Biologicals BST2 Lysates
    Sino Biological Recombinant Protein for BST2
    Sino Biological Cell Lysate for BST2 
    ProSpec Recombinant Protein for BST2
    Cloud-Clone Corp. Proteins for BST2 

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737colocalizes with cytoplasm IDA--
    GO:0005770late endosome IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0005886plasma membrane IDA19036818

    BST2 for ontologies           About GeneDecksing



    BST2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of BST2
    R&D Systems Antibodies for BST2 (BST2/Tetherin)
    OriGene Antibodies for BST2
    OriGene Custom Antibody Services for BST2
    GenScript Custom Superior Antibodies Services for BST2
    Novus Biologicals BST2 Antibodies
    Abcam antibodies for BST2
    Cloud-Clone Corp. Antibodies for BST2 
    ThermoFisher Antibodies for BST2
    LSBio Antibodies in human, mouse, rat for BST2 

    Assay Products for BST2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BST2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BST2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BST2 
    Cloud-Clone Corp. CLIAs for BST2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules

    1 InterPro protein domain:
     IPR024886 BST2

    Graphical View of Domain Structure for InterPro Entry Q10589

    ProtoNet protein and cluster: Q10589

    UniProtKB/Swiss-Prot: BST2_HUMAN, Q10589
    Domain: The extracellular coiled coil domain forms an extended 170 A long semi-flexible rod-like structure
    important for virion retention at the cell surface and prevention of virus spreading
    Similarity: Belongs to the tetherin family


    BST2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BST2_HUMAN, Q10589
    Function: IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian
    enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct
    physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can
    be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case,
    their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including
    retroviridae: human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), simian
    immunodeficiency viruses (SIVs), equine infectious anemia virus (EIAV), feline immunodeficiency virus (FIV),
    prototype foamy virus (PFV), Mason-Pfizer monkey virus (MPMV), human T-cell leukemia virus type 1 (HTLV-1), Rous
    sarcoma virus (RSV) and murine leukemia virus (MLV), flavivirideae: hepatitis C virus (HCV), filoviridae: ebola
    virus (EBOV) and marburg virus (MARV), arenaviridae: lassa virus (LASV) and machupo virus (MACV), herpesviridae:
    kaposis sarcoma-associated herpesvirus (KSHV), rhabdoviridae: vesicular stomatitis virus (VSV), orthomyxoviridae:
    influenza A virus, and paramyxoviridae: nipah virus. Can inhibit cell surface proteolytic activity of MMP14
    causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate
    signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid
    dendritic cells in response to viral infection. Plays a role in the organization of the subapical actin
    cytoskeleton in polarized epithelial cells
    Induction: By type I interferons. Down-regulated by viral antagonistic factors which include: HIV-1 VPU protein,
    HIV-2 ENV protein, KSHV K5 protein and ebola virus GP protein. VPU and ENV antagonize its function by targeting
    it to the trans-Golgi network, sequestering it away from virus assembly sites on the cell membrane. VPU also acts
    as an adapter molecule linking it to BTRC, a substrate recognition subunit of the Skp1/Cullin/F-box protein E3
    ubiquitin ligase, inducing its ubiquitination and subsequent proteasomal degradation. K5 ubiquitinates it leading
    to its targeting to late endosomes and degradation

         Genatlas biochemistry entry for BST2:
    bone marrow stromal antigen 2,involved in pre-B-cell growth,36kDa,expressed in various tissues

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IMP12761501
    GO:0005515protein binding IPI19564354
    GO:0008191metalloendopeptidase inhibitor activity IDA--
    GO:0042803protein homodimerization activity IPI--
         
    BST2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for BST2:
     Increased gamma-H2AX phosphory 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Bst2):
     cellular  hematopoietic system  immune system  no phenotypic analysis 

    BST2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Bst2tm1.1Bsz for BST2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for BST2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BST2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BST2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BST2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BST2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate BST2
    SwitchGear 3'UTR luciferase reporter plasmidBST2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for BST2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BST2

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of BST2

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    OriGene ORF clones in mouse, rat for BST2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BST2 (NM_004335)
    Sino Biological Human cDNA Clone for BST2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BST2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BST2
    Sirion Biotech Customized lentivirus for stable overexpression of BST2 
                         Customized lentivirus expression plasmids for stable overexpression of BST2 

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BST2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BST2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/8 Interacting proteins for BST2 (Q105892, 3 ENSP000002525934) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    BTRCQ9Y2973I2D: score=1 
    LILRA4P599013I2D: score=1 
    TFRCP027863I2D: score=1 
    HAGHENSP000003805144STRING: ENSP00000380514
    About this table

    Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002737negative regulation of plasmacytoid dendritic cell cytokine production IDA19564354
    GO:0006959humoral immune response TAS7607676
    GO:0007165signal transduction IMP12761501
    GO:0007267cell-cell signaling TAS7607676
    GO:0007275multicellular organismal development TAS7607676

    BST2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BST2

    Search CenterWatch for drugs/clinical trials and news about BST2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BST2 gene: 
    NM_004335.3  

    Unigene Cluster for BST2:

    Bone marrow stromal cell antigen 2
    Hs.118110  [show with all ESTs]
    Unigene Representative Sequence: BQ679629
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000252593(uc002ngl.3) ENST00000533098 ENST00000527220
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BST2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate BST2
    SwitchGear 3'UTR luciferase reporter plasmidBST2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BST2
    Clone
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    GenScript: all cDNA clones in your preferred vector: BST2 (NM_004335)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BST2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BST2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BST2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BST2

    Additional mRNA sequence: 

    AK223124.1 AK291099.1 AK303593.1 AY320400.1 AY320402.1 BC033873.1 D28137.1 

    9 DOTS entries:

    DT.75161707  DT.101973854  DT.91757455  DT.97819337  DT.100796120  DT.102829816  DT.91757448  DT.95150545 
    DT.95370619 

    24/399 AceView cDNA sequences (see all 399):

    BI223714 BQ057827 BX481937 BU168554 BU854816 BP341915 BQ053580 BE896478 
    BG165219 BM688662 BQ230530 BQ716644 BI115017 BQ058341 BE275026 AL560990 
    BM562301 BX474586 BI819227 BG385866 BM829102 BI819604 CR591045 CB999904 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BST2 expression in normal human tissues (normalized intensities)      BST2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTGCCTGT
    BST2 Expression
    About this image


    BST2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Uncategorized (Uncategorized)    fully expand to see all 5 entries
             PureStem Progenitor W10
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             C2a
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Human Ovarian Microvascular Endothelial Cells (HOMEC)   
     
     Endothelium (Reproductive System)    fully expand to see all 2 entries
             Human Ovarian Microvascular Endothelial Cells (HOMEC)   
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Human Renal Mesangial Cells (HRMC)   

    See BST2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BST2

    SOURCE GeneReport for Unigene cluster: Hs.118110

    UniProtKB/Swiss-Prot: BST2_HUMAN, Q10589
    Tissue specificity: Predominantly expressed in liver, lung, heart and placenta. Lower levels in pancreas, kidney,
    skeletal muscle and brain. Overexpressed in multiple myeloma cells. Highly expressed during B-cell development,
    from pro-B precursors to plasma cells. Highly expressed on T-cells, monocytes, NK cells and dendritic cells (at
    protein level)

        SABiosciences Expression via Pathway-Focused PCR Array including BST2: 
              Type I Interferon Response in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BST2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BST2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for BST2 gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bst21 , 5 bone marrow stromal cell antigen 21, 5 58.27(n)1
    46.67(a)1
      8 (34.43 cM)5
    695501  NM_198095.21  NP_932763.11 
     715342645 


    ENSEMBL Gene Tree for BST2 (if available)
    TreeFam Gene Tree for BST2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/34 SNPs in BST2 are shown (see all 34)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0120674
    ----see VAR_0120672 V F mis40--------
    rs1137246881,2
    F--17445510(+) GAAACG/AGTGAG 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1503500571,2
    C--17445564(+) CAAGGG/TCTGGG 1 -- ds50010--------
    rs23036831,2
    C,F,A,H--17445694(-) TTAGTC/ACCCAA 1 -- ds500130Minor allele frequency- A:0.23EA NS NA WA CSA 4276
    rs22455191,2
    C,F,A,H--17445728(-) CACCTT/GACTCT 1 -- ds500124Minor allele frequency- G:0.29EA NS NA WA CSA 3838
    rs10543241,2
    C--17445782(-) TTTTTT/CTGGGG 1 -- ut31 ese32Minor allele frequency- C:0.17MN NA 186
    rs1996841361,2
    C--17445793(+) AGCAA-/CCCCCC 1 -- ut310--------
    rs134851,2
    C,F,A--17445905(-) CAGAGC/GCTCCC 1 -- ut31 ese38Minor allele frequency- G:0.21MN NA CSA WA EA 736
    rs95761,2
    C,F,A,H--17445960(-) TGGGGC/AAGTCC 1 -- ut3125Minor allele frequency- A:0.23EA MN NS NA WA CSA 3928
    rs10542311,2
    H--17446022(-) GGTTAG/ACGGGG 1 -- ut31 ese36Minor allele frequency- A:0.01MN NS EA NA 586

    HapMap Linkage Disequilibrium report for BST2 (17513748 - 17516457 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for BST2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv911182CNV Loss21882294
    nsv911198CNV Loss21882294
    nsv833768CNV Loss17160897
    nsv911201CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing BST2
    DNA2.0 Custom Variant and Variant Library Synthesis for BST2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600534    OMIM disorders: --

    20/25 diseases for BST2 (see all 25):    About MalaCards
    west nile encephalitis    megakaryocytic leukemia    rheumatoid arthritis    hiv/aids
    mumps    arthritis    kaposi's sarcoma    encephalitis
    stomatitis    multiple myeloma    human t-cell leukemia virus type 1    down syndrome
    influenza    myeloma    sarcoma    renal cell carcinoma
    hepatitis b    t-cell leukemia    anemia    hepatitis c

    2 diseases from the University of Copenhagen DISEASES database for BST2:
    Multiple myeloma     West Nile encephalitis

    BST2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    1 Novoseek inferred disease relationship for BST2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 31.2 8 20078884 (1), 19605472 (1), 20147395 (1)

    Genetic Association Database (GAD): BST2
    Human Genome Epidemiology (HuGE) Navigator: BST2 (2 documents)

    Export disorders for BST2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BST2 gene, integrated from 9 sources (see all 214) (see top 10):
    (articles sorted by number of sources associating them with BST2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth. (PubMed id 7607676)1, 2, 3, 9 Ishikawa J.... Hirano T. (1995)
    2. The formation of cysteine-linked dimers of BST-2/teth erin is important for inhibition of HIV-1 virus release but not for sensitivity to Vpu. (PubMed id 19737401)1, 2, 9 Andrew A.J....Strebel K. (2009)
    3. Regulation of TLR7/9 responses in plasmacytoid dendri tic cells by BST2 and ILT7 receptor interaction. (PubMed id 19564354)1, 2, 9 Cao W....Liu Y.J. (2009)
    4. HIV-1 accessory protein Vpu internalizes cell-surface BST-2/tetherin through transmembrane interactions leading to lysosomes. (PubMed id 19837671)1, 2, 9 Iwabu Y....Tokunaga K. (2009)
    5. Vpu and BST2: still not there yet? (PubMed id 22509177)1, 2 Sato K.... Koyanagi Y. (2012)
    6. Modulation of hepatitis C virus release by the interfe ron-induced protein BST-2/tetherin. (PubMed id 22520941)1, 2 Dafa-Berger A....Taube R. (2012)
    7. Restriction of retroviral replication by tetherin/BST-2. (PubMed id 22811908)1, 2 Hammonds J.... Spearman P. (2012)
    8. Antiviral inhibition of enveloped virus release by tet herin/BST-2: action and counteraction. (PubMed id 21994744)1, 2 Le Tortorec A....Neil S.J. (2011)
    9. structural basis for the antiviral activity of Bst-2/tetherin and its viral antagonism. (PubMed id 22180752)1, 2 Arias J.F.... Tokunaga K. (2011)
    10. Tetherin and its viral antagonists. (PubMed id 21222046)1, 2 Kuhl B.D....Liang C. (2011)
    11. Tetherin inhibits prototypic foamy virus release. (PubMed id 21529378)1, 2 Xu F....Qiao W. (2011)
    12. Influenza virus is not restricted by tetherin whereas influenza VLP production is restricted by tetherin. (PubMed id 21621240)1, 2 Watanabe R....Lamb R.A. (2011)
    13. BST-2/tetherin: a new component of the innate immune response to enveloped viruses. (PubMed id 20688520)1, 2 Evans D.T.... Guatelli J.C. (2010)
    14. Structural insight into the mechanisms of enveloped v irus tethering by tetherin. (PubMed id 20940320)1, 2 Yang H....Xiong Y. (2010)
    15. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    16. The RING-CH ligase K5 antagonizes restriction of KSHV and HIV-1 particle release by mediating ubiquitin-dependent endosomal degradation of tetherin. (PubMed id 20419159)1, 2 Pardieu C.... Neil S.J. (2010)
    17. Structural basis of HIV-1 tethering to membranes by t he BST-2/tetherin ectodomain. (PubMed id 20399176)1, 2 Hinz A....Weissenhorn W. (2010)
    18. Structural and functional studies on the extracellula r domain of BST2/tetherin in reduced and oxidized conformations. (PubMed id 20880831)1, 2 Schubert H.L....Hill C.P. (2010)
    19. Infectious Lassa virus, but not filoviruses, is restr icted by BST-2/tetherin. (PubMed id 20686043)1, 2 Radoshitzky S.R....Bavari S. (2010)
    20. Broad-spectrum inhibition of retroviral and filoviral particle release by tetherin. (PubMed id 19036818)1, 2 Jouvenet N....Bieniasz P.D. (2009)
    21. Antagonism to and intracellular sequestration of huma n tetherin by the human immunodeficiency virus type 2 envelope glycoprotein. (PubMed id 19740980)1, 2 Le Tortorec A. and Neil S.J. (2009)
    22. Tetherin inhibits HIV-1 release by directly tethering virions to cells. (PubMed id 19879838)1, 2 Perez-Caballero D....Bieniasz P.D. (2009)
    23. A tail of Tetherin: how pandemic HIV-1 conquered the w orld. (PubMed id 19917491)1, 2 Gupta R.K. and Towers G.J. (2009)
    24. The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein. (PubMed id 18342597)1, 2 Van Damme N.... Guatelli J. (2008)
    25. Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu. (PubMed id 18200009)1, 2 Neil S.J....Bieniasz P.D. (2008)
    26. Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol- anchored proteins released upon phospholipase D treatment. (PubMed id 16602701)1, 2 Elortza F.... Jensen O.N. (2006)
    27. Characterization of antibodies submitted to the B cell section of the 8th Human Leukocyte Differentiation Antigens Workshop by flow cytometry and immunohistochemistry. (PubMed id 16157322)1, 2 Vidal-Laliena M....Engel P. (2005)
    28. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    29. Molecular cloning and characterization of a surface antigen preferentially overexpressed on multiple myeloma cells. (PubMed id 10329429)1, 2 Ohtomo T.... Tsuchiya M. (1999)
    30. Vpu directs the degradation of the human immunodefici ency virus restriction factor BST-2/Tetherin via a {beta}TrCP-dependent mechani sm. (PubMed id 19515779)1, 9 Douglas J.L....Moses A.V. (2009)
    31. Molecular mechanism of BST2/tetherin downregulation b y K5/MIR2 of Kaposi's sarcoma-associated herpesvirus. (PubMed id 19605472)1, 9 Mansouri M....FrA1h K. (2009)
    32. Direct restriction of virus release and incorporation of the interferon-induced protein BST-2 into HIV-1 particles. (PubMed id 20221443)1, 9 Fitzpatrick K....Guatelli J. (2010)
    33. Antiviral activity of the interferon-induced cellular protein BST-2/tetherin. (PubMed id 19929170)1, 9 Tokarev A....Guatelli J. (2009)
    34. Interferon-alpha enhances CD317 expression and the antitumor activity of anti-CD317 monoclonal antibody in renal cell carcinoma xenograft models. (PubMed id 19032371)1, 9 Kawai S....Yamada-Okabe H. (2008)
    35. Antagonism of CD317 restriction of human immunodefici ency virus type 1 (HIV-1) particle release and depletion of CD317 are separable activities of HIV-1 Vpu. (PubMed id 20147395)1, 9 Goffinet C....Fackler O.T. (2010)
    36. A flow cytometry-based FRET assay to identify and ana lyse protein-protein interactions in living cells. (PubMed id 20179761)1, 9 Banning C....Schindler M. (2010)
    37. Vpu serine 52 dependent counteraction of tetherin is required for HIV-1 replication in macrophages, but not in ex vivo human lymphoi d tissue. (PubMed id 20078884)1, 9 Schindler M....Kirchhoff F. (2010)
    38. The Vpu protein: new concepts in virus release and CD 4 down-modulation. (PubMed id 20201792)1, 9 Ruiz A....Stephens E.B. (2010)
    39. The transmembrane domain of BST-2 determines its sens itivity to down-modulation by human immunodeficiency virus type 1 Vpu. (PubMed id 19474106)1, 9 Rong L....Liang C. (2009)
    40. BST-2/tetherin-mediated restriction of chikungunya (CH IKV) VLP budding is counteracted by CHIKV non-structural protein 1 (nsP1). (PubMed id 23411007)1 Jones P.H....Okeoma C.M. (2013)
    41. Ig-like transcript 7, but not bone marrow stromal cell antigen 2 (also known as HM1.24, tetherin, or CD317), modulates plasmacytoid de ndritic cell function in primary human blood leukocytes. (PubMed id 23401591)1 Tavano B....Boasso A. (2013)
    42. Roles played by capsid-dependent induction of membrane curvature and Gag-ESCRT interactions in tetherin recruitment to HIV-1 assembly sites. (PubMed id 23408603)1 Grover J.R....Ono A. (2013)
    43. Stimulation of NF-kB activity by the HIV restriction f actor BST2. (PubMed id 23221546)1 Tokarev A....Guatelli J. (2013)
    44. Human immunodeficiency virus-1 BF intersubtype recombi nant viral protein U second a helix plays an important role in viral release and BST-2 degradation. (PubMed id 23223624)1 De Candia C....Carobene M. (2013)
    45. The transmembrane domain of HIV-1 Vpu is sufficient to confer anti-tetherin activity to SIVcpz and SIVgor Vpu proteins: cytoplasmic de terminants of Vpu function. (PubMed id 23514615)1 Kluge S.F....Kirchhoff F. (2013)
    46. Targeting antigen to bone marrow stromal cell-2 expres sed by conventional and plasmacytoid dendritic cells elicits efficient antigen p resentation. (PubMed id 23303646)1 Moffat J.M....Mintern J.D. (2013)
    47. Association of BST-2 gene variants with HIV disease pr ogression underscores the role of BST-2 in HIV type 1 infection. (PubMed id 23148293)1 Laplana M....Fibla J. (2013)
    48. TLR-4 engagement of dendritic cells confers a BST-2/te therin-mediated restriction of HIV-1 infection to CD4+ T cells across the virolo gical synapse. (PubMed id 23311681)1 Blanchet F.P....Piguet V. (2013)
    49. Antagonism to human BST-2/tetherin by Sendai virus gly coproteins. (PubMed id 23468424)1 Bampi C....Roux L. (2013)
    50. Cell-cell transmission allows human T-lymphotropic vir us 1 to circumvent tetherin restriction. (PubMed id 23260108)1 Ilinskaya A....Heidecker G. (2013)
    51. A comparative mutational analysis of HIV-1 Vpu subtype s B and C for the identification of determinants required to counteract BST-2/Te therin and enhance viral egress. (PubMed id 23582304)1 Douglas J.L....Moses A.V. (2013)
    52. HIV-1 Vpu interference with innate cell-mediated immun e mechanisms. (PubMed id 22524181)1 Sandberg J.K....Moll M. (2012)
    53. The size and conservation of a coiled-coil structure i n the ectodomain of human BST-2/tetherin is dispensable for inhibition of HIV-1 virion release. (PubMed id 23152502)1 Andrew A.J....Strebel K. (2012)
    54. Counteraction of tetherin antiviral activity by two cl osely related SIVs differing by the presence of a Vpu gene. (PubMed id 22530020)1 Nikovics K....Saragosti S. (2012)
    55. Transmembrane interactions of HIV-1 Vpu and tetherin. (PubMed id 22524177)1 Guo F. and Liang C. (2012)
    56. Intrinsic cellular defenses against human immunodefici ency viruses. (PubMed id 22999946)1 Blanco-Melo D....Bieniasz P.D. (2012)
    57. BST-2 binding with cellular MT1-MMP blocks cell growth and migration via decreasing MMP2 activity. (PubMed id 22065321)2 Gu G.... Liu P. (2012)
    58. The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain. (PubMed id 22405001)1 Agromayor M....Williams R.L. (2012)
    59. The tetherin/BST-2 coiled-coil ectodomain mediates pla sma membrane microdomain localization and restriction of particle release. (PubMed id 22130541)1 Hammonds J....Spearman P. (2012)
    60. Influenza A virus does not encode a tetherin antagonis t with Vpu-like activity and induces IFN-dependent tetherin expression in infect ed cells. (PubMed id 22952667)1 Winkler M....Pohlmann S. (2012)
    61. HIV-1 Vpu and BST-2/tetherin: enemies at the gates. (PubMed id 22533470)1 Tokunaga K. (2012)
    62. b-TrCP dependency of HIV-1 Vpu-induced downregulation of CD4 and BST-2/tetherin. (PubMed id 22524179)1 Blanchet F.P....Piguet V. (2012)
    63. Expression analysis of LEDGF/p75, APOBEC3G, TRIM5alpha , and tetherin in a Senegalese cohort of HIV-1-exposed seronegative individuals. (PubMed id 22479480)1 Mous K....Van Ostade X. (2012)
    64. Innate sensing of HIV-1 assembly by Tetherin induces N FkB-dependent proinflammatory responses. (PubMed id 23159053)1 Galao R.P....Neil S.J. (2012)
    65. HIV types, groups, subtypes and recombinant forms: err ors in replication, selection pressure and quasispecies. (PubMed id 22286874)1 Eberle J. and Gurtler L. (2012)
    66. The structural biology of HIV-1: mechanistic and thera peutic insights. (PubMed id 22421880)1 Engelman A. and Cherepanov P. (2012)
    67. The cellular antiviral restriction factor tetherin doe s not inhibit poxviral replication. (PubMed id 22090135)1 Sliva K....Schnierle B.S. (2012)
    68. HIV-1 Vpu protein antagonizes innate restriction facto r BST-2 via lipid-embedded helix-helix interactions. (PubMed id 22072710)1 Skasko M....Guatelli J. (2012)
    69. Anti-tetherin activities of HIV-1 Vpu and Ebola virus glycoprotein do not involve removal of tetherin from lipid rafts. (PubMed id 22398279)1 Lopez L.A....Cannon P.M. (2012)
    70. Identification of alternatively translated Tetherin is oforms with differing antiviral and signaling activities. (PubMed id 23028328)1 Cocka L.J. and Bates P. (2012)
    71. Tetherin has negligible activity in restricting hepati tis C virus in hepatocytes. (PubMed id 21940748)1 Ye L....Ho W. (2012)
    72. Influenza virus partially counteracts restriction impo sed by tetherin/BST-2. (PubMed id 22493439)1 Mangeat B....Piguet V. (2012)
    73. Dimerization of the transmembrane domain of human teth erin in membrane mimetic environments. (PubMed id 22667354)1 Cole G....Sharpe S. (2012)
    74. Structural basis of tetherin function. (PubMed id 22524178)1 Weissenhorn W....Gottlinger H.G. (2012)
    75. Characterization of the interface of the bone marrow s tromal cell antigen 2-Vpu protein complex via computational chemistry. (PubMed id 22264038)1 Zhou J....Cen S. (2012)
    76. IL-27 increases BST-2 expression in human monocytes an d T cells independently of type I IFN. (PubMed id 23240078)1 Guzzo C....Gee K. (2012)
    77. Role of the endosomal ESCRT machinery in HIV-1 Vpu-ind uced down-regulation of BST2/tetherin. (PubMed id 22524180)1 Janvier K....Berlioz-Torrent C. (2012)
    78. Sites of action of HIV-1 Vpu in BST-2/tetherin downreg ulation. (PubMed id 22524176)1 Arias J.F....Tokunaga K. (2012)
    79. Delineating HIV-associated neurocognitive disorders us ing transgenic models: the neuropathogenic actions of Vpr. (PubMed id 21918813)1 Power C....Polyak M. (2012)
    80. Adaptation of human and simian immunodeficiency viruse s for resistance to tetherin/BST-2. (PubMed id 22524175)1 Serra-Moreno R. and Evans D.T. (2012)
    81. Tetherin/BST-2 is essential for the formation of the i ntracellular virus-containing compartment in HIV-infected macrophages. (PubMed id 22980332)1 Chu H....Spearman P. (2012)
    82. The role of the structural domains of human BST-2 in i nhibiting the release of xenotropic murine leukemia virus-related virus. (PubMed id 23047007)1 Hu S....Guo F. (2012)
    83. Inhibition of virus-like particle release of Sendai vi rus and Nipah virus, but not that of mumps virus, by tetherin/CD317/BST-2. (PubMed id 23077864)1 Kong W.S....Sakaguchi T. (2012)
    84. Species tropism of HIV-1 modulated by viral accessory proteins. (PubMed id 22855686)1 Nomaguchi M....Adachi A. (2012)
    85. Vpu-deficient HIV strains stimulate innate immune sign aling responses in target cells. (PubMed id 22647704)1 Doehle B.P....Gale M. (2012)
    86. Virus-activated interferon regulatory factor 7 upregul ates expression of the interferon-regulated BST2 gene independently of interfero n signaling. (PubMed id 22301143)1 Bego M.G....Cohen E.A. (2012)
    87. Vpu augments the initial burst phase of HIV-1 propagat ion and downregulates BST2 and CD4 in humanized mice. (PubMed id 22357275)1 Sato K....Koyanagi Y. (2012)
    88. A cytoplasmic tail determinant in HIV-1 Vpu mediates t argeting of tetherin for endosomal degradation and counteracts interferon-induce d restriction. (PubMed id 22479182)1 Kueck T. and Neil S.J. (2012)
    89. Ubiquitination of BST-2 protein by HIV-1 Vpu protein d oes not require lysine, serine, or threonine residues within the BST-2 cytoplasm ic domain. (PubMed id 22383521)1 Gustin J.K....Moses A.V. (2012)
    90. Role of retroviral restriction factors in the interfer on-a-mediated suppression of HIV-1 in vivo. (PubMed id 22315404)1 Pillai S.K....Wong J.K. (2012)
    91. HIV-1 Vpu's lipid raft association is dispensable for counteraction of the particle release restriction imposed by CD317/Tetherin. (PubMed id 22222210)1 Fritz J.V....Fackler O.T. (2012)
    92. TRIM5alpha and species tropism of HIV/SIV. (PubMed id 22291694)1 Nakayama E.E. and Shioda T. (2012)
    93. HIV Restriction Factors and Mechanisms of Evasion. (PubMed id 22553496)1 Malim M.H. and Bieniasz P.D. (2012)
    94. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    95. The interferon-inducible host factor bone marrow stromal antigen 2/tetherin restricts virion release, but is it actually a viral restriction factor? (PubMed id 21166593)2 Andrew A. and Strebel K. (2011)
    96. Tetherin does not significantly restrict dendritic ce ll-mediated HIV-1 transmission and its expression is upregulated by newly synth esized HIV-1 Nef. (PubMed id 21504576)1 Coleman C.M....Wu L. (2011)
    97. Differential effects of human immunodeficiency virus type 1 Vpu on the stability of BST-2/tetherin. (PubMed id 21191020)1 Andrew A.J....Strebel K. (2011)
    98. Lack of adaptation to human tetherin in HIV-1 group O and P. (PubMed id 21955466)1 Yang S.J....Cannon P.M. (2011)
    99. Tetherin antagonism by primate lentiviral nef proteins . (PubMed id 22103835)1 Sauter D. and Kirchhoff F. (2011)
    100. Feline tetherin efficiently restricts release of felin e immunodeficiency virus but not spreading of infection. (PubMed id 21490095)1 Dietrich I....Willett B.J. (2011)
    101. Vpu-mediated tetherin antagonism of ongoing HIV-1 inf ection in CD4(+) T-cells is not directly related to the extent of tetherin cell surface downmodulation. (PubMed id 21757214)1 Kuhl B.D....Wainberg M.A. (2011)
    102. SIV envelope acquires a nefarious habit. (PubMed id 21238941)1 Neil S. (2011)
    103. Some human immunodeficiency virus type 1 Vpu proteins are able to antagonize macaque BST-2 in vitro and in vivo: Vpu-negative simian-h uman immunodeficiency viruses are attenuated in vivo. (PubMed id 21775449)1 Shingai M....Strebel K. (2011)
    104. Role of the endocytic pathway in the counteraction of BST-2 by human lentiviral pathogens. (PubMed id 21813615)1 Lau D....Guatelli J. (2011)
    105. Rab7A is required for efficient production of infectio us HIV-1. (PubMed id 22072966)1 Caillet M....Berlioz-Torrent C. (2011)
    106. C-terminal hydrophobic region in human bone marrow st romal cell antigen 2 (BST-2)/tetherin protein functions as second transmembrane motif. (PubMed id 21937450)1 Andrew A.J....Strebel K. (2011)
    107. SIV Nef proteins recruit the AP-2 complex to antagoni ze Tetherin and facilitate virion release. (PubMed id 21625568)1 Zhang F....Hatziioannou T. (2011)
    108. Separable determinants of subcellular localization and interaction account for the inability of group O HIV-1 Vpu to counteract tether in. (PubMed id 21775465)1 Vigan R. and Neil S.J. (2011)
    109. [Inhibition of HIV virus-like particles production by BST-2]. (PubMed id 21874899)1 Du Y.L....Guo F. (2011)
    110. HIV-1 Vpu blocks recycling and biosynthetic transport of the intrinsic immunity factor CD317/tetherin to overcome the virion release restriction. (PubMed id 21610122)1 Schmidt S....Keppler O.T. (2011)
    111. The HIV-1 Vpu viroporin inhibitor BIT225 does not affe ct Vpu-mediated tetherin antagonism. (PubMed id 22110710)1 Kuhl B.D....Wainberg M.A. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 684 HGNC: 1119 AceView: BST2 Ensembl:ENSG00000130303 euGenes: HUgn684
    ECgene: BST2 H-InvDB: BST2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BST2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BST2 gene:
    Search GeneIP for patents involving BST2

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of BST2
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
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     Antibodies for BST2 (BST2/Tetherin)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for BST2   OriGene RNAi products in human, mouse, rat for BST2  
     OriGene qPCR primer pairs and template standards for BST2   OriGene Protein Over-expression Lysate for BST2  
     OriGene MassSpec something-or-other for BST2   OriGene clones in human, mouse for BST2  
     OriGene qSTAR qPCR primer pairs in human, mouse for BST2   OriGene Purified Protein for BST2  
     OriGene ORF clones in mouse, rat for BST2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for BST2   OriGene Custom Protein Services for BST2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BST2
     QIAGEN SeqTarget long-range PCR primers for resequencing BST2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BST2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BST2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BST2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BST2
     GenScript Custom Purified and Recombinant Proteins Services for BST2 GenScript cDNA clones with any tag delivered in your preferred vector for BST2
     GenScript Custom Assay Services for BST2 GenScript Custom Superior Antibodies Services for BST2
     GenScript Custom overexpressing Cell Line Services for BST2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in BST2 promoter
     Search Chromatin IP Primers for BST2
     RT2 qPCR Primer Assay in human, mouse, rat BST2
     Search GNC Networks for BST2
     SABiosciences PCR Arrays including human, mouse, rat BST2
     Search Tocris compounds for BST2
     Proteins and Antibodies for BST2
     Cell Lysates for BST2
     cDNA Clones for BST2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     BST2 antibodies
     BST2 proteins
     BST2 lysates
     Antibodies for BST2
     See all of Abcam's Antibodies, Kits and Proteins for BST2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for BST2




     Proteins for BST2
     Antibodies for BST2
     ELISAs for BST2
     CLIAs for BST2
     Search LifeMap BioReagents cell lines for BST2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BST2
     SwitchGear 3'UTR luciferase reporter plasmids for BST2
     SwitchGear Promoter luciferase reporter plasmids for BST2
     ThermoFisher Antibodies for BST2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BST2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for BST2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BST2
    Customized:
     lentivirus for stable overexpression of BST2
     lentivirus expression plasmids for stable overexpression of BST2
     adenovirus for overexpression of BST2
     LSBio Antibodies in human, mouse, rat for BST2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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