Aliases for BST2 Gene
Aliases for BST2 Gene
External Ids for BST2 Gene
- HGNC: 1119
- Entrez Gene: 684
- Ensembl: ENSG00000130303
- OMIM: 600534
- UniProtKB: Q10589
Previous GeneCards Identifiers for BST2 Gene
- GC19M018007
- GC19M017906
- GC19M017358
- GC19M017374
- GC19M017502
- GC19M017080
- GC19M017513
Summaries for BST2 Gene
-
Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the protein encoded by the bone marrow stromal cell antigen 2 is undetermined; however, this protein may play a role in pre-B-cell growth and in rheumatoid arthritis. [provided by RefSeq, Jul 2008]
GeneCards Summary for BST2 Gene
BST2 (Bone Marrow Stromal Cell Antigen 2) is a Protein Coding gene. Diseases associated with BST2 include Stomatitis and Chikungunya. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. Gene Ontology (GO) annotations related to this gene include signal transducer activity.
UniProtKB/Swiss-Prot for BST2 Gene
-
IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), simian immunodeficiency viruses (SIVs), equine infectious anemia virus (EIAV), feline immunodeficiency virus (FIV), prototype foamy virus (PFV), Mason-Pfizer monkey virus (MPMV), human T-cell leukemia virus type 1 (HTLV-1), Rous sarcoma virus (RSV) and murine leukemia virus (MLV), flavivirideae: hepatitis C virus (HCV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), arenaviridae: lassa virus (LASV) and machupo virus (MACV), herpesviridae: kaposis sarcoma-associated herpesvirus (KSHV), rhabdoviridae: vesicular stomatitis virus (VSV), orthomyxoviridae: influenza A virus, and paramyxoviridae: nipah virus. Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection (PubMed:19564354, PubMed:26172439). Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. Isoform 1 and isoform 2 are both effective viral restriction factors but have differing antiviral and signaling activities (PubMed:23028328, PubMed:26172439). Isoform 2 is resistant to HIV-1 Vpu-mediated degradation and restricts HIV-1 viral budding in the presence of Vpu (PubMed:23028328, PubMed:26172439). Isoform 1 acts as an activator of NF-kappa-B and this activity is inhibited by isoform 2 (PubMed:23028328).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BST2 Gene
Genomics for BST2 Gene
GeneHancer (GH) Regulatory Elements for BST2 Gene
Promoters and enhancers for BST2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around BST2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the BST2 gene promoter:
Regulatory Element Products
Genomic Locations for BST2 Gene
Genomic Locations for BST2 Gene
- chr19:17,402,939-17,405,648
- (GRCh38/hg38)
- Size:
- 2,710 bases
- Orientation:
- Minus strand
- chr19:17,513,748-17,516,457
- (GRCh37/hg19)
Genomic View for BST2 Gene
Genes around BST2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.11 by Ensembl
- 19p13.11 by Entrez Gene
- 19p13.11 by HGNC
BST2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for BST2 Gene
Proteins for BST2 Gene
-
Protein details for BST2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q10589-BST2_HUMAN
- Recommended name:
- Bone marrow stromal antigen 2
- Protein Accession:
- Q10589
- A8K4Y4
- Q53G07
Protein attributes for BST2 Gene
- Size:
- 180 amino acids
- Molecular mass:
- 19769 Da
- Quaternary structure:
-
- Parallel homodimer; disulfide-linked. May form homotetramers under reducing conditions. Isoform 1 and isoform 2 form homodimers and also heterodimers with each other. Dimerization is essential for its antiviral activity. Interacts (via cytoplasmic domain) with ARHGAP44 (By similarity). Interacts with MMP14 (via C-terminal cytoplasmic tail) (PubMed:22065321). Interacts with LILRA4/ILT7 (PubMed:19564354, PubMed:26172439). Interacts (via transmembrane domain) with HIV-1 VPU (via transmembrane domain) (PubMed:19837671). Interacts with HIV-2 ENV and ebola GP protein (PubMed:19740980, PubMed:19179289).
- Miscellaneous:
-
- Tetherin shows evidence of positive (adaptive) selection, presumably as a result of evolutionary pressure applied by antagonistic viral proteins that counteract its inhibitiory activity and this has led to the species-specific tetherin sensitivity to viral countermeasures. For example, Tantalus monkey tetherin cannot be abrogated by HIV-1 VPU due to variation in the tetherin transmembrane region. Similarly, SIV Nefs are able to overcome simian tetherins, but not human tetherin, due to a unique 5-amino-acid deletion in the cytoplasmic tail domain of human tetherin (PubMed:19917491).
Three dimensional structures from OCA and Proteopedia for BST2 Gene
Protein Expression for BST2 Gene
Post-translational modifications for BST2 Gene
- Monoubiquitinated by KSHV E3 ubiquitin-protein ligase K5, leading to its targeting to late endosomes and degradation.
- The GPI anchor is essential for its antiviral activity.
- Ubiquitination at posLast=1818
- Glycosylation at Asn65, posLast=9292, Thr121, and posLast=131131
Other Protein References for BST2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for BST2 (BST-2/Tetherin)
- Cell Signaling Technology (CST) Antibodies for BST2 (BST2)
- Novus Biologicals Antibodies for BST2
-
Abcam antibodies for BST2
-
Cloud-Clone Corp. Antibodies for BST2
- Invitrogen Antibodies for BST2
- antibodies-online: Search results for 177 available BST2 Antibodies ranked by validation data
- Compare Top BST2 Antibodies
-
Recommended
- 114 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 7 FACS Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 2 ICFC Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 24 WB Antibodies (anti-mouse)
- 21 FACS Antibodies (anti-mouse)
- 4 IP Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 1 ICC Antibody (anti-mouse)
- 15 WB Antibodies (anti-rat)
- GeneTex BST2 antibody for BST2
-
Santa Cruz Biotechnology (SCBT) Antibodies for BST2
- Sino Biological Antibodies for BST2
Protein Products
-
OriGene Purified Proteins for BST2
- Search Origene for MassSpec and Protein Over-expression Lysates for BST2
- Origene Custom Protein Services for BST2
- Sino Biological Cell Lysates for BST2
- Sino Biological Recombinant Proteins for BST2
- ProSpec Recombinant Proteins for BST2
-
Cloud-Clone Corp. Proteins for BST2
- Search GeneTex for Proteins for BST2
-
ProSci Proteins for BST2
-
Abcam proteins for BST2
Assay Products
-
Cloud-Clone Corp. Assay Kits for BST2
-
Abcam assays for BST2
No data available for DME Specific Peptides for BST2 Gene
Domains & Families for BST2 Gene
Gene Families for BST2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- CD markers
- Plasma proteins
- Predicted membrane proteins
Suggested Antigen Peptide Sequences for BST2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q10589UniProtKB/Swiss-Prot:
BST2_HUMAN :- The extracellular coiled coil domain forms an extended 170 A long semi-flexible rod-like structure important for virion retention at the cell surface and prevention of virus spreading.
- Belongs to the tetherin family.
- Domain:
-
- The extracellular coiled coil domain forms an extended 170 A long semi-flexible rod-like structure important for virion retention at the cell surface and prevention of virus spreading.
- Family:
-
- Belongs to the tetherin family.
Function for BST2 Gene
Molecular function for BST2 Gene
- GENATLAS Biochemistry:
- bone marrow stromal antigen 2,involved in pre-B-cell growth,36kDa,expressed in various tissues
- UniProtKB/Swiss-Prot Function:
- IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), simian immunodeficiency viruses (SIVs), equine infectious anemia virus (EIAV), feline immunodeficiency virus (FIV), prototype foamy virus (PFV), Mason-Pfizer monkey virus (MPMV), human T-cell leukemia virus type 1 (HTLV-1), Rous sarcoma virus (RSV) and murine leukemia virus (MLV), flavivirideae: hepatitis C virus (HCV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), arenaviridae: lassa virus (LASV) and machupo virus (MACV), herpesviridae: kaposis sarcoma-associated herpesvirus (KSHV), rhabdoviridae: vesicular stomatitis virus (VSV), orthomyxoviridae: influenza A virus, and paramyxoviridae: nipah virus. Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection (PubMed:19564354, PubMed:26172439). Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. Isoform 1 and isoform 2 are both effective viral restriction factors but have differing antiviral and signaling activities (PubMed:23028328, PubMed:26172439). Isoform 2 is resistant to HIV-1 Vpu-mediated degradation and restricts HIV-1 viral budding in the presence of Vpu (PubMed:23028328, PubMed:26172439). Isoform 1 acts as an activator of NF-kappa-B and this activity is inhibited by isoform 2 (PubMed:23028328).
- UniProtKB/Swiss-Prot Induction:
- By type I interferons. Down-regulated by viral antagonistic factors which include: HIV-1 VPU protein, HIV-2 ENV protein, KSHV K5 protein and ebola virus GP protein. VPU and ENV antagonize its function by targeting it to the trans-Golgi network, sequestering it away from virus assembly sites on the cell membrane. VPU also acts as an adapter molecule linking it to BTRC, a substrate recognition subunit of the Skp1/Cullin/F-box protein E3 ubiquitin ligase, inducing its ubiquitination and subsequent proteasomal degradation. K5 ubiquitinates it leading to its targeting to late endosomes and degradation.
Phenotypes From GWAS Catalog for BST2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA,IDA | 22658674 |
| GO:0004871 | signal transducer activity | IMP,HMP | 12761501 |
| GO:0005515 | protein binding | IPI | 19179289 |
| GO:0008191 | metalloendopeptidase inhibitor activity | IDA | 22065321 |
| GO:0042802 | identical protein binding | IPI | 19879838 |
Phenotypes for BST2 Gene
- GenomeRNAi human phenotypes for BST2:
-
- Increased gamma-H2AX phosphorylation
- Decreased hepcidin::fluc mRNA expression
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Decreased IL-8 secretion
- Decreased viability
- Increased shRNA abundance (Z-score > 2)
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased shRNA abundance (Z-score < -2)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for BST2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for BST2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for BST2 gene
- Search ViGene Biosciences for BST2
CRISPR Products
-
OriGene CRISPR knockouts for BST2
- genomics-online: gRNA clones - Search results for 124 available BST2 gene related products
- Overview of 124 available BST2 gene related products
- Applied Biological Materials CRISPR for BST2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for BST2
- GenScript: Design CRISPR guide RNA sequences for BST2
miRNA Products
- Search ViGene Biosciences for BST2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for BST2
- Browse OriGene Inhibitory RNA Products For BST2
- genomics-online: shRNA clones - Search results for 124 available BST2 gene related products
- Overview of 124 available BST2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for BST2 gene
Clone Products
- Sino Biological Human cDNA Clone for BST2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for BST2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BST2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for BST2
- Applied Biological Materials Clones for BST2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for BST2 (BST-2/Tetherin)
Cell Line Products
-
Horizon Cell Lines for BST2
-
ViGene Biosciences adenoviral particle packaged cDNA for BST2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for BST2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for BST2 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BST2 Gene
Localization for BST2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for BST2 Gene
- Golgi apparatus, trans-Golgi network. Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor, GPI-anchor. Late endosome. Membrane raft. Cytoplasm. Apical cell membrane. Note=Shuttles between the cell membrane, where it is present predominantly in membrane/lipid rafts, and the trans-Golgi network. HIV-1 VPU and HIV-2 ENV can target it to the trans-Golgi network thus sequestering it away from virus assembly sites on the cell membrane. Targeted to late endosomes upon KSHV infection and subsequent ubiquitination. Forms a complex with MMP14 and localizes to the cytoplasm.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytosol | 5 |
| lysosome | 5 |
| golgi apparatus | 5 |
| endosome | 4 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
- Cytosol (3)
- Golgi apparatus (3)
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | colocalizes_with cytoplasm | IDA,IEA | 22065321 |
| GO:0005768 | endosome | IEA | -- |
| GO:0005770 | late endosome | IEA | -- |
| GO:0005771 | multivesicular body | IMP | 22072966 |
| GO:0005794 | Golgi apparatus | IDA,IEA | -- |
Pathways & Interactions for BST2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | Cytokine Signaling in Immune system | ||
| 3 | Immune response IFN alpha/beta signaling pathway | ||
| 4 | Interferon gamma signaling | ||
Pathways by source for BST2 Gene
6 Reactome pathways for BST2 Gene
Interacting Proteins for BST2 Gene
Selected Interacting proteins:
ENSP00000252593
Q10589-BST2_HUMAN
for BST2 Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002737 | negative regulation of plasmacytoid dendritic cell cytokine production | IDA | 19564354 |
| GO:0006959 | humoral immune response | TAS | 7607676 |
| GO:0007267 | cell-cell signaling | TAS | 7607676 |
| GO:0007275 | multicellular organism development | TAS | 7607676 |
| GO:0008283 | cell proliferation | TAS | 7607676 |
No data available for SIGNOR curated interactions for BST2 Gene
Transcripts for BST2 Gene
mRNA/cDNA for BST2 Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (399) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for BST2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for BST2
- genomics-online: gRNA clones - Search results for 124 available BST2 gene related products
- Overview of 124 available BST2 gene related products
- Applied Biological Materials CRISPR for BST2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for BST2
- GenScript: Design CRISPR guide RNA sequences for BST2
miRNA Products
- Search ViGene Biosciences for BST2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for BST2
- Browse OriGene Inhibitory RNA Products For BST2
- genomics-online: shRNA clones - Search results for 124 available BST2 gene related products
- Overview of 124 available BST2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for BST2 gene
Clone Products
- Sino Biological Human cDNA Clone for BST2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for BST2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BST2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for BST2
- Applied Biological Materials Clones for BST2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for BST2 (BST-2/Tetherin)
Expression for BST2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
- Bone (Muscoskeletal System)
- Endoderm (Gastrulation Derivatives)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Adrenal Gland (Endocrine System)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for BST2 Gene
This gene is overexpressed in Ovary (x6.9) and Adrenal Gland (x5.6).
This gene is overexpressed in Adipocyte (11.9), Ovary (11.7), and Testis (7.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BST2 Gene
NURSA nuclear receptor signaling pathways regulating expression of BST2 Gene:
BST2SOURCE GeneReport for Unigene cluster for BST2 Gene:
Hs.118110mRNA Expression by UniProt/SwissProt for BST2 Gene:
Q10589-BST2_HUMAN
Tissue specificity:
Predominantly expressed in liver, lung, heart and placenta. Lower levels in pancreas, kidney, skeletal muscle and brain. Overexpressed in multiple myeloma cells. Highly expressed during B-cell development, from pro-B precursors to plasma cells. Highly expressed on T-cells, monocytes, NK cells and dendritic cells (at protein level).
Evidence on tissue expression from TISSUES for BST2 Gene
- Liver(4.6)
- Blood(4.5)
- Spleen(3.4)
- Lymph node(2.8)
- Kidney(2.5)
- Bone marrow(2.3)
- Adrenal gland(2.2)
- Lung(2.2)
- Heart(2)
- Nervous system(2)
Primer Products
-
OriGene qPCR primer pairs for BST2
-
OriGene qPCR primer pairs and template standards for BST2
- genomics-online: primer clones - Search results for 124 available BST2 gene related products
- Overview of 124 available BST2 gene related products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for BST2 Gene
Orthologs for BST2 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | BST2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | BST2 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Bst2 34 |
|
OneToOne |
- Species where no ortholog for BST2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for BST2 Gene
No data available for Paralogs for BST2 Gene
Variants for BST2 Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000906895 | -- | 17,406,000(-) | C/T | upstream_transcript_variant | |
| rs1000937391 | -- | 17,406,221(-) | C/T | upstream_transcript_variant | |
| rs1001694957 | -- | 17,406,924(-) | G/T | upstream_transcript_variant | |
| rs1002035142 | -- | 17,405,696(-) | G/C | upstream_transcript_variant | |
| rs1002947281 | -- | 17,404,930(-) | C/T | intron_variant |
Residual Variation Intolerance Score:
57.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.13;
2.97% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for BST2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BST2 Gene
Disorders for BST2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| stomatitis |
|
|
| chikungunya |
|
|
| west nile encephalitis |
|
|
| ebola hemorrhagic fever |
|
|
| human immunodeficiency virus type 1 |
|
|
Search BST2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for BST2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for BST2 Gene
Publications for BST2 Gene
- Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth. (PMID: 7607676) Ishikawa J … Ishihara K (Genomics 1995) 2 3 4 22 58
- HIV-1 accessory protein Vpu internalizes cell-surface BST-2/tetherin through transmembrane interactions leading to lysosomes. (PMID: 19837671) Iwabu Y … Tokunaga K (The Journal of biological chemistry 2009) 3 4 22 58
- Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction. (PMID: 19564354) Cao W … Liu YJ (The Journal of experimental medicine 2009) 3 4 22 58
- The formation of cysteine-linked dimers of BST-2/tetherin is important for inhibition of HIV-1 virus release but not for sensitivity to Vpu. (PMID: 19737401) Andrew AJ … Strebel K (Retrovirology 2009) 3 4 22 58
- Vpu Exploits the Cross-Talk between BST2 and the ILT7 Receptor to Suppress Anti-HIV-1 Responses by Plasmacytoid Dendritic Cells. (PMID: 26172439) Bego MG … Cohen ÉA (PLoS pathogens 2015) 3 4 58
Products for BST2 Gene
- R&D Systems Antibodies for BST2 (BST-2/Tetherin)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- R&D Systems cDNA Clones for BST2 (BST-2/Tetherin)
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for BST2
- Search Origene for MassSpec and Protein Over-expression Lysates for BST2
- Origene Custom Protein Services for BST2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for BST2
- Browse OriGene Inhibitory RNA Products For BST2
- OriGene qPCR primer pairs and template standards for BST2
- OriGene qPCR primer pairs for BST2
- OriGene CRISPR knockouts for BST2
- OriGene ORF clones in human for BST2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For BST2
- GenScript: Next-day shipping of latest version cDNA ORF clones for BST2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for BST2
- GenScript Custom Assay Services for BST2
- GenScript Custom overexpressing Cell Line Services for BST2
- GenScript: Design CRISPR guide RNA sequences for BST2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for BST2
- Cell Signaling Technology (CST) Antibodies for BST2 (BST2)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for BST2
- Sino Biological Cell Lysates for BST2
- Sino Biological Recombinant Proteins for BST2
- Sino Biological Antibodies for BST2
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for BST2
- Novus Biologicals proteins and lysates for BST2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for BST2
- Abcam proteins for BST2
- Abcam assays for BST2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for BST2
- Cloud-Clone Corp. Antibodies for BST2
- Cloud-Clone Corp. Proteins for BST2
- Cloud-Clone Corp. Assay Kits for BST2
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for BST2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for BST2
- VectorBuilder custom plasmid, inducible vectors for BST2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for BST2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for BST2
- antibodies-online: Search results for 177 available BST2 Antibodies ranked by validation data
- Compare Top BST2 Antibodies
- Recommended
- 114 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 7 FACS Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 2 ICFC Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 24 WB Antibodies (anti-mouse)
- 21 FACS Antibodies (anti-mouse)
- 4 IP Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 1 ICC Antibody (anti-mouse)
- 15 WB Antibodies (anti-rat)
- antibodies-online: Search results for 8 available BST2 Elisa Kits ranked by validation data
- Compare Top BST2 Elisa Kits
- antibodies-online: Search results for 23 available BST2 Proteins ranked by validation data
- Compare Top BST2 Proteins
- GeneTex BST2 antibody for BST2
- Search GeneTex for Proteins for BST2
- ViGene Biosciences adenoviral particle packaged cDNA for BST2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for BST2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for BST2 gene
- Search ViGene Biosciences for BST2
- Santa Cruz Biotechnology (SCBT) Antibodies for BST2
- Search Santa Cruz Biotechnology (SCBT) for BST2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for BST2
- Search for BST2 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for BST2
- Horizon Cell Lines for BST2
- genomics-online: cdna clones - Search results for 124 available BST2 gene related products
- Overview of 124 available BST2 gene related products
- orf clones - Search results for 124 available BST2 gene related products
- Overview of 124 available BST2 gene related products
- genomics-online: gRNA clones - Search results for 124 available BST2 gene related products
- Overview of 124 available BST2 gene related products
- genomics-online: primer clones - Search results for 124 available BST2 gene related products
- Overview of 124 available BST2 gene related products
- genomics-online: shRNA clones - Search results for 124 available BST2 gene related products
- Overview of 124 available BST2 gene related products
Sources for BST2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew