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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BST1 Gene

protein-coding   GIFtS: 65
GCID: GC04P015704

Bone Marrow Stromal Cell Antigen 1

Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Bone Marrow Stromal Cell Antigen 11 2     BST-12 3
ADP-Ribosyl Cyclase 21 2     CADPr Hydrolase 22 3
NAD(+) Nucleosidase1 2     CD1572
Bone Marrow Stromal Antigen 12 3     EC 3.2.2.53
Cyclic ADP-Ribose Hydrolase 22 3     CD157 Antigen3

External Ids:    HGNC: 11181   Entrez Gene: 6832   Ensembl: ENSG000001097437   OMIM: 6003875   UniProtKB: Q105883   

Export aliases for BST1 gene to outside databases

Previous GC identifers: GC04P015519 GC04P015646 GC04P015392 GC04P015455 GC04P015380 GC04P015055


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BST1 Gene:
Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule
that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1
expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The
polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1
overexpression in the stromal cell population. (provided by RefSeq, Jul 2008)

GeneCards Summary for BST1 Gene: 
BST1 (bone marrow stromal cell antigen 1) is a protein-coding gene. Diseases associated with BST1 include rheumatoid arthritis, and hemoglobinuria, and among its related super-pathways are NAD metabolism and Metabolism. GO annotations related to this gene include nucleotide binding and NAD+ nucleosidase activity. An important paralog of this gene is CD38.

UniProtKB/Swiss-Prot: BST1_HUMAN, Q10588
Function: Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular
stores. May be involved in pre-B-cell growth

Gene Wiki entry for BST1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_006316.16  NC_018915.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for BST1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): BST1 promoter sequence
   Search SABiosciences Chromatin IP Primers for BST1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BST1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p15   Ensembl cytogenetic band:  4p15.32   HGNC cytogenetic band: 4p15

BST1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BST1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P015704:  view genomic region     (about GC identifiers)

Start:
15,704,573 bp from pter      End:
15,739,936 bp from pter
Size:
35,364 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BST1_HUMAN, Q10588 (See protein sequence)
Recommended Name: ADP-ribosyl cyclase 2 precursor  
Size: 318 amino acids; 35724 Da
Subunit: Homodimer
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor
6 PDB 3D structures from and Proteopedia for BST1:
1ISF (3D)        1ISG (3D)        1ISH (3D)        1ISI (3D)        1ISJ (3D)        1ISM (3D)    
Secondary accessions: B2R6A2 Q5U0K0 Q96EN3

Explore the universe of human proteins at neXtProt for BST1: NX_Q10588

Explore proteomics data for BST1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q10588

  • BST1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BST1 Protein Expression
    REFSEQ proteins: NP_004325.2  
    ENSEMBL proteins: 
     ENSP00000265016   ENSP00000371783   ENSP00000423357   ENSP00000420925   ENSP00000424761  

    Human Recombinant Protein Products for BST1: 
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    OriGene Protein Over-expression Lysate for BST1
    OriGene MassSpec for BST1 
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    Novus Biologicals BST1 Protein
    Novus Biologicals BST1 Lysate
    Sino Biological Recombinant Protein for BST1
    Sino Biological Cell Lysate for BST1 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BST1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0019898extrinsic to membrane TAS8202488
    GO:0031225anchored to membrane IEA--

    BST1 for ontologies           About GeneDecksing



    BST1 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for BST1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules

    2 InterPro protein domains:
     IPR016040 NAD(P)-bd_dom
     IPR003193 ADP-ribosyl_cyclase

    Graphical View of Domain Structure for InterPro Entry Q10588

    ProtoNet protein and cluster: Q10588

    1 Blocks protein domain: IPB003193 ADP-ribosyl cyclase (CD38/157)

    UniProtKB/Swiss-Prot: BST1_HUMAN, Q10588
    Similarity: Belongs to the ADP-ribosyl cyclase family


    BST1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BST1_HUMAN, Q10588
    Function: Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular
    stores. May be involved in pre-B-cell growth
    Catalytic activity: NAD(+) + H(2)O = ADP-ribose + nicotinamide

         Genatlas biochemistry entry for BST1:
    bone marrow stromal antigens,involved in pre-B-cell growth,expressed in various tissues

         Enzyme Number (IUBMB): EC 3.2.2.51

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003953NAD+ nucleosidase activity IEA--
         
    BST1 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Bst1):
     cellular  hematopoietic system  immune system 

    BST1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Bst1tm1Thir for BST1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for BST1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BST1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BST1 
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    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate BST1:
    hsa-miR-103a-2*
    SwitchGear 3'UTR luciferase reporter plasmidBST1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BST1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BST1 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1NAD metabolism
    NAD metabolism0.43
    Nicotinate and nicotinamide metabolism0.43
    2Metabolism
    Metabolic pathways0.40
    3Gastric acid secretion
    Salivary secretion0.34
    4Pancreatic secretion
    Pancreatic secretion
    5Epstein-Barr virus infection
    Epstein-Barr virus infection

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for BST1
        NAD metabolism


    1 GeneGo (Thomson Reuters) Pathway for BST1
        NAD metabolism



    5/6         Kegg Pathways  (Kegg details for BST1) (see all 6):
        Nicotinate and nicotinamide metabolism
    Metabolic pathways
    Calcium signaling pathway
    Salivary secretion
    Pancreatic secretion


    BST1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BST1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/21 Interacting proteins for BST1 (Q105883 ENSP000002650164) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAV1Q031353, ENSP000003391914I2D: score=1 STRING: ENSP00000339191
    CD38ENSP000002262794STRING: ENSP00000226279
    ENPP1ENSP000003542384STRING: ENSP00000354238
    ENPP3ENSP000003502654STRING: ENSP00000350265
    NADKENSP000003416794STRING: ENSP00000341679
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006959humoral immune response TAS8202488
    GO:0007275multicellular organismal development TAS8202488

    BST1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BST1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BST1

    8 HMDB Compounds for BST1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADP-ribose 2'-phosphate2'-phosphoadenosine 5'-[3-(D-ribofuranosyl) dihydrogen diphosphate] (see all 3)26303-90-2--
    Adenosine diphosphate ribose(Rib5)ppA (see all 13)20762-30-5--
    CalciumCa (see all 2)7440-70-2--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    Niacinamide3-Carbamoylpyridine (see all 77)98-92-0--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    5 DrugBank Compounds for BST1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine-5'-Diphosphate Monothiophosphate-- --target--17139284 17016423
    Etheno-Nad-- --target--17139284 17016423
    Etheno-Nadp-- --target--17139284 17016423
    Nicotinamide-- 98-92-0target--17139284 17016423
    Nicotinamide Mononucleotide-- --target--17139284 17016423

    4 Novoseek inferred chemical compound relationships for BST1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclic adp-ribose 89 8 8645283 (2), 9895292 (1), 18626062 (1), 9030974 (1)
    nad+ 71.1 13 19052657 (2), 12415565 (1), 18626062 (1), 18019526 (1)
    retinoic acid 16.9 3 12139742 (1), 11089918 (1)
    calcium 8.35 4 9895292 (1), 17380196 (1)

    Search CenterWatch for drugs/clinical trials and news about BST1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BST1 gene: 
    NM_004334.2  

    Unigene Cluster for BST1:

    Bone marrow stromal cell antigen 1
    Hs.720344  [show with all ESTs]
    Unigene Representative Sequence: NM_004334
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265016(uc003goh.4) ENST00000382346 ENST00000505785 ENST00000514445
    ENST00000514989

    miRNA
    Products:
         
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate BST1:
    hsa-miR-103a-2*
    SwitchGear 3'UTR luciferase reporter plasmidBST1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB175627.1 AK312497.1 BC012095.1 BT019502.1 D21878.1 

    7 DOTS entries:

    DT.113039  DT.121249013  DT.97802314  DT.91849737  DT.97835893  DT.75109255  DT.100746236 

    24/67 AceView cDNA sequences (see all 67):

    AI266729 BP375001 AL599287 BI908623 CR603536 AI825103 BU732655 BX103493 
    BQ018460 CD369441 D21878 AW075772 BC012095 AA557150 BX443941 BX358630 
    AI140774 BM547881 N39926 AU280058 BM544278 BG751777 AW950679 H80057 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BST1 expression in normal human tissues (normalized intensities)      BST1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCGCCGCG
    BST1 Expression
    About this image


    BST1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Blood (Hematopoietic System)
             Conventional Dendritic Cells I Spleen
     
     Smooth Muscle (Muscoskeletal System)
             Coronary Artery Smooth Muscle Cells (CASMC)   
     
     Blood Brain Barrier (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Neural Tube (Nervous System)
             Prosencephalon

    See BST1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BST1

    SOURCE GeneReport for Unigene cluster: Hs.720344

    UniProtKB/Swiss-Prot: BST1_HUMAN, Q10588
    Tissue specificity: Widely expressed

        SABiosciences Custom PCR Arrays for BST1
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BST1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BST1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for BST1 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bst11 , 5 bone marrow stromal cell antigen 11, 5 77.42(n)1
    73.23(a)1
      5 (23.84 cM)5
    121821  NM_009763.31  NP_033893.21 
     438188865 
    chicken
    (Gallus gallus)
    Aves BST11 bone marrow stromal cell antigen 1 64.61(n)
    54.44(a)
      422828  NM_001200043.1  NP_001186972.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CR318624.16
    Uncharacterized protein
    32(a)
    1 → many
    24(8806391-8815691)


    ENSEMBL Gene Tree for BST1 (if available)
    TreeFam Gene Tree for BST1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BST1 gene
    CD382  
    1 SIMAP similar gene for BST1 using alignment to 6 protein entries:     BST1_HUMAN (see all proteins):
    CD38

    BST1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/717 SNPs in BST1 are shown (see all 717)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs76903621,2
    C,F,A,H--15702697(+) acctgT/Agacct 1 -- us2k110Minor allele frequency- A:0.18NA WA CSA 17
    rs2011844731,2
    --15703070(+) TACAG-/AAAAAA 1 -- us2k10--------
    rs174061281,2
    C,F,H--15703135(+) CAAGTG/ACTTGC 1 -- us2k1 tfbs39Minor allele frequency- A:0.04NA EA NS WA 774
    rs1136183201,2
    C--15703258(+) ACTCTG/TTTGCC 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1449880601,2
    --15703443(+) GTCTCA/GATCTC 1 -- us2k10--------
    rs76969381,2
    C,F,A,H--15703577(+) AGGGAG/TATTGT 1 -- us2k132Minor allele frequency- T:0.27NS EA NA WA CSA 2900
    rs1149922031,2
    F--15703607(+) TCGGCG/AGTAGG 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1434036331,2
    --15703740(+) TCCAGA/GTTCCT 1 -- us2k10--------
    rs1466818731,2
    --15703878(+) ATGTTC/TCTCAT 1 -- us2k10--------
    rs1928659801,2
    --15703903(+) ATTTGA/GATGAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for BST1 (15704573 - 15739936 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for BST1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv27101CNV Loss19812545
    nsv822495CNV Loss20364138
    nsv10459CNV Loss18304495
    dgv864n67CNV Loss20364138
    nsv428439CNV Gain+Loss18775914
    dgv1587e1CNV Complex17122850
    dgv1586e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): BST1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing BST1
    DNA2.0 Custom Variant and Variant Library Synthesis for BST1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600387    OMIM disorders: --

    5 diseases for BST1:    About MalaCards
    rheumatoid arthritis    hemoglobinuria    arthritis    parkinson's disease
    pancreatitis


    BST1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    3 Novoseek inferred disease relationships for BST1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paroxysmal hemoglobinuria nocturnal 58.1 1 15328157 (1)
    leukemia 22.6 1 11528102 (1)
    rheumatoid arthritis 3.59 3 8630113 (2)

    Genetic Association Database (GAD): BST1
    Human Genome Epidemiology (HuGE) Navigator: BST1 (10 documents)

    Export disorders for BST1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BST1 gene, integrated from 9 sources (see all 58):
    (articles sorted by number of sources associating them with BST1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. BST-1, a surface molecule of bone marrow stromal cell lines that facilitates pre-B-cell growth. (PubMed id 8202488)1, 2, 3 Kaisho T.... Hirano T. (1994)
    2. Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities. (PubMed id 11866528)1, 2, 9 Yamamoto-Katayama S....Morikawa K. (2002)
    3. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide associat ion studies. (PubMed id 21292315)1, 4  ....Wood N.W. (2011)
    4. Analysis of GWAS-linked loci in Parkinson disease rea ffirms PARK16 as a susceptibility locus. (PubMed id 20697102)1, 4 Tan E.K....Liu J.J. (2010)
    5. Common genetic variation in the HLA region is associa ted with late-onset sporadic Parkinson's disease. (PubMed id 20711177)1, 4 Hamza T.H....Payami H. (2010)
    6. Genome-wide association study identifies common varia nts at four loci as genetic risk factors for Parkinson's disease. (PubMed id 19915576)1, 4 Satake W....Toda T. (2009)
    7. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. CD157 is an important mediator of neutrophil adhesion and migration. (PubMed id 15328157)1, 9 Funaro A....Malavasi F. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 683 HGNC: 1118 AceView: BST1 Ensembl:ENSG00000109743 euGenes: HUgn683
    ECgene: BST1 Kegg: 683 H-InvDB: BST1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BST1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BST1 gene:
    Search GeneIP for patents involving BST1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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