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Aliases for BST1 Gene

Aliases for BST1 Gene

  • Bone Marrow Stromal Cell Antigen 1 2 3
  • ADP-Ribosyl Cyclase 2 2 3 4
  • Bone Marrow Stromal Antigen 1 3 4
  • Cyclic ADP-Ribose Hydrolase 2 3 4
  • NAD(+) Nucleosidase 2 3
  • CADPr Hydrolase 2 3 4
  • BST-1 3 4
  • ADP-Ribosyl Cyclase/Cyclic ADP-Ribose Hydrolase 2 3
  • CD157 Antigen 4
  • EC 3.2.2.6 4
  • CD157 3

External Ids for BST1 Gene

Summaries for BST1 Gene

Entrez Gene Summary for BST1 Gene

  • Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population. [provided by RefSeq, Jul 2008]

GeneCards Summary for BST1 Gene

BST1 (Bone Marrow Stromal Cell Antigen 1) is a Protein Coding gene. Diseases associated with BST1 include rheumatoid arthritis and arthritis. Among its related pathways are Nicotinate and nicotinamide metabolism and Salivary secretion. GO annotations related to this gene include NAD+ nucleosidase activity. An important paralog of this gene is CD38.

UniProtKB/Swiss-Prot for BST1 Gene

  • Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.

Gene Wiki entry for BST1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BST1 Gene

Genomics for BST1 Gene

Genomic Location for BST1 Gene

Start:
15,702,950 bp from pter
End:
15,739,498 bp from pter
Size:
36,549 bases
Orientation:
Plus strand

Genomic View for BST1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BST1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BST1 Gene

No data available for Regulatory Elements for BST1 Gene

Proteins for BST1 Gene

  • Protein details for BST1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q10588-BST1_HUMAN
    Recommended name:
    ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
    Protein Accession:
    Q10588
    Secondary Accessions:
    • B2R6A2
    • Q1XII0
    • Q5U0K0
    • Q96EN3

    Protein attributes for BST1 Gene

    Size:
    318 amino acids
    Molecular mass:
    35724 Da
    Quaternary structure:
    • Homodimer

    Three dimensional structures from OCA and Proteopedia for BST1 Gene

    Alternative splice isoforms for BST1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BST1 Gene

Proteomics data for BST1 Gene at MOPED

Post-translational modifications for BST1 Gene

  • Glycosylation at Asn66, Asn95, Asn148, and Asn192

Other Protein References for BST1 Gene

No data available for DME Specific Peptides for BST1 Gene

Domains for BST1 Gene

Gene Families for BST1 Gene

HGNC:
  • CD :CD molecules

Protein Domains for BST1 Gene

UniProtKB/Swiss-Prot:

BST1_HUMAN
Family:
  • Belongs to the ADP-ribosyl cyclase family.:
    • Q10588
genes like me logo Genes that share domains with BST1: view

Function for BST1 Gene

Molecular function for BST1 Gene

GENATLAS Biochemistry: bone marrow stromal antigens,involved in pre-B-cell growth,expressed in various tissues
UniProtKB/Swiss-Prot CatalyticActivity: NAD(+) + H(2)O = ADP-D-ribose + nicotinamide
UniProtKB/Swiss-Prot Function: Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.

Enzyme Numbers (IUBMB) for BST1 Gene

Gene Ontology (GO) - Molecular Function for BST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003953 NAD+ nucleosidase activity IBA --
GO:0016740 transferase activity IEA --
GO:0016849 phosphorus-oxygen lyase activity IBA --
GO:0050135 NAD(P)+ nucleosidase activity IEA --
genes like me logo Genes that share ontologies with BST1: view

Phenotypes for BST1 Gene

genes like me logo Genes that share phenotypes with BST1: view

Animal Models for BST1 Gene

MGI Knock Outs for BST1:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for BST1 Gene

Localization for BST1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BST1 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BST1 Gene COMPARTMENTS Subcellular localization image for BST1 gene
Compartment Confidence
plasma membrane 5
extracellular 3
lysosome 1

Gene Ontology (GO) - Cellular Components for BST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0019898 extrinsic component of membrane TAS 8202488
GO:0031225 anchored component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with BST1: view

Pathways for BST1 Gene

genes like me logo Genes that share pathways with BST1: view

Pathways by source for BST1 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for BST1 Gene

Gene Ontology (GO) - Biological Process for BST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006959 humoral immune response TAS 8202488
GO:0007275 multicellular organismal development TAS 8202488
GO:0008152 metabolic process IBA --
GO:0030890 positive regulation of B cell proliferation IBA --
genes like me logo Genes that share ontologies with BST1: view

Compounds for BST1 Gene

(8) HMDB Compounds for BST1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine diphosphate ribose
  • (Rib5)ppA
20762-30-5
ADP-ribose 2'-phosphate
  • 2'-phosphoadenosine 5'-[3-(D-ribofuranosyl) dihydrogen diphosphate]
26303-90-2
Calcium
  • Ca
7440-70-2
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4

(5) Drugbank Compounds for BST1 Gene

(4) Novoseek inferred chemical compound relationships for BST1 Gene

Compound -log(P) Hits PubMed IDs
cyclic adp-ribose 89 5
nad+ 71.1 5
retinoic acid 16.9 2
calcium 8.35 2
genes like me logo Genes that share compounds with BST1: view

Transcripts for BST1 Gene

Unigene Clusters for BST1 Gene

Bone marrow stromal cell antigen 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BST1 Gene

No ASD Table

Relevant External Links for BST1 Gene

GeneLoc Exon Structure for
BST1
ECgene alternative splicing isoforms for
BST1

Expression for BST1 Gene

mRNA expression in normal human tissues for BST1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BST1 Gene

This gene is overexpressed in Whole Blood (27.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BST1 Gene

SOURCE GeneReport for Unigene cluster for BST1 Gene Hs.720344

mRNA Expression by UniProt/SwissProt for BST1 Gene

Q10588-BST1_HUMAN
Tissue specificity: Widely expressed
genes like me logo Genes that share expressions with BST1: view

Orthologs for BST1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BST1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BST1 36
  • 98.32 (n)
  • 96.54 (a)
BST1 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BST1 36
  • 82.53 (n)
  • 76.55 (a)
BST1 37
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BST1 36
  • 82.63 (n)
  • 78.32 (a)
BST1 37
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bst1 36
  • 79.21 (n)
  • 74.91 (a)
Bst1 16
Bst1 37
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BST1 37
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BST1 37
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bst1 36
  • 78.55 (n)
  • 72.56 (a)
chicken
(Gallus gallus)
Aves BST1 36
  • 64.61 (n)
  • 54.44 (a)
BST1 37
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bst1 36
  • 57.98 (n)
  • 50.58 (a)
zebrafish
(Danio rerio)
Actinopterygii CR318624.1 37
  • 34 (a)
OneToMany
Species with no ortholog for BST1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BST1 Gene

ENSEMBL:
Gene Tree for BST1 (if available)
TreeFam:
Gene Tree for BST1 (if available)

Paralogs for BST1 Gene

Paralogs for BST1 Gene

Selected SIMAP similar genes for BST1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with BST1: view

Variants for BST1 Gene

Sequence variations from dbSNP and Humsavar for BST1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs2103 -- 15,736,860(-) TATGA(C/T)AGACA intron-variant
rs955410 -- 15,734,911(-) TCCCA(A/T)AGTCT intron-variant
rs955411 -- 15,734,884(-) TGAGC(A/G)TGGCC intron-variant
rs997250 -- 15,737,875(+) AGCCG(A/G)AATCT utr-variant-3-prime
rs1058212 -- 15,731,831(+) CTTCC(A/C)GGACT reference, synonymous-codon, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BST1 Gene

Variant ID Type Subtype PubMed ID
dgv1586e1 CNV Complex 17122850
dgv1587e1 CNV Complex 17122850
nsv428439 CNV Gain+Loss 18775914
dgv864n67 CNV Loss 20364138
esv27101 CNV Loss 19812545
nsv10459 CNV Loss 18304495
nsv822495 CNV Loss 20364138

Relevant External Links for BST1 Gene

HapMap Linkage Disequilibrium report
BST1
Human Gene Mutation Database (HGMD)
BST1

Disorders for BST1 Gene

(3) Novoseek inferred disease relationships for BST1 Gene

Disease -log(P) Hits PubMed IDs
paroxysmal hemoglobinuria nocturnal 58.1 1
leukemia 22.6 1
rheumatoid arthritis 3.59 2

Relevant External Links for BST1

Genetic Association Database (GAD)
BST1
Human Genome Epidemiology (HuGE) Navigator
BST1
genes like me logo Genes that share disorders with BST1: view

No data available for UniProtKB/Swiss-Prot for BST1 Gene

Publications for BST1 Gene

  1. Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities. (PMID: 11866528) Yamamoto-Katayama S. … Morikawa K. (J. Mol. Biol. 2002) 3 4 23
  2. BST-1, a surface molecule of bone marrow stromal cell lines that facilitates pre-B-cell growth. (PMID: 8202488) Kaisho T. … Hirano T. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  5. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T. … Smith R.D. (J. Proteome Res. 2005) 3 4

Products for BST1 Gene

Sources for BST1 Gene

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