Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



BST1 Gene

protein-coding   GIFtS: 61
GCID: GC04P015704

Bone Marrow Stromal Cell Antigen 1

  See BST1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Bone Marrow Stromal Cell Antigen 11 2     BST-12 3
ADP-Ribosyl Cyclase 21 2     CADPr Hydrolase 22 3
NAD(+) Nucleosidase1 2     CD1572
Bone Marrow Stromal Antigen 12 3     EC 3.2.2.53
Cyclic ADP-Ribose Hydrolase 22 3     CD157 Antigen3

External Ids:    HGNC: 11181   Entrez Gene: 6832   Ensembl: ENSG000001097437   OMIM: 6003875   UniProtKB: Q105883   

Export aliases for BST1 gene to outside databases

Previous GC identifers: GC04P015519 GC04P015646 GC04P015392 GC04P015455 GC04P015380 GC04P015055


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for BST1 Gene:
Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule
that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1
expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The
polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1
overexpression in the stromal cell population. (provided by RefSeq, Jul 2008)

GeneCards Summary for BST1 Gene:
BST1 (bone marrow stromal cell antigen 1) is a protein-coding gene. Diseases associated with BST1 include rheumatoid arthritis, and arthritis. GO annotations related to this gene include NAD+ nucleosidase activity. An important paralog of this gene is CD38.

UniProtKB/Swiss-Prot: BST1_HUMAN, Q10588
Function: Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular
stores. May be involved in pre-B-cell growth

Gene Wiki entry for BST1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Search for regulatory transcription factor binding sites for BST1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): BST1 promoter sequence
   Search Chromatin IP Primers for BST1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BST1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p15   Ensembl cytogenetic band:  4p15.32   HGNC cytogenetic band: 4p15

BST1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BST1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P015704:  view genomic region     (about GC identifiers)

Start:
15,704,573 bp from pter      End:
15,739,936 bp from pter
Size:
35,364 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: BST1_HUMAN, Q10588 (See protein sequence)
Recommended Name: ADP-ribosyl cyclase 2 precursor  
Size: 318 amino acids; 35724 Da
Subunit: Homodimer
6 PDB 3D structures from and Proteopedia for BST1:
1ISF (3D)        1ISG (3D)        1ISH (3D)        1ISI (3D)        1ISJ (3D)        1ISM (3D)    
Secondary accessions: B2R6A2 Q5U0K0 Q96EN3

Explore the universe of human proteins at neXtProt for BST1: NX_Q10588

Explore proteomics data for BST1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn66, Asn95, Asn148, Asn192

  • See BST1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004325.2  
    ENSEMBL proteins: 
     ENSP00000265016   ENSP00000371783   ENSP00000423357   ENSP00000420925   ENSP00000424761  

    BST1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for BST1 (CD157)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for BST1
    OriGene Protein Over-expression Lysate for BST1
    OriGene MassSpec for BST1
    OriGene Custom Protein Services for BST1
    GenScript Custom Purified and Recombinant Proteins Services for BST1
    Novus Biologicals BST1 Protein
    Novus Biologicals BST1 Lysate
    Sino Biological Recombinant Protein for BST1
    Sino Biological Cell Lysate for BST1
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BST1

     
    Search eBioscience for Proteins for BST1 

    BST1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for BST1 (CD157)
    OriGene Antibodies for BST1
    OriGene Custom Antibody Services for BST1
    Novus Biologicals BST1 Antibodies
    Abcam antibodies for BST1
    Cloud-Clone Corp. Antibodies for BST1
    ThermoFisher Antibodies for BST1
    LSBio Antibodies in human, mouse, rat for BST1

    BST1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BST1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BST1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BST1
    Cloud-Clone Corp. CLIAs for BST1
    Search eBioscience for ELISAs for BST1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CD: CD molecules

    2 InterPro protein domains:
     IPR003193 ADP-ribosyl_cyclase
     IPR016040 NAD(P)-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q10588

    ProtoNet protein and cluster: Q10588

    1 Blocks protein domain: IPB003193 ADP-ribosyl cyclase (CD38/157)

    UniProtKB/Swiss-Prot: BST1_HUMAN, Q10588
    Similarity: Belongs to the ADP-ribosyl cyclase family


    Find genes that share domains with BST1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BST1_HUMAN, Q10588
    Function: Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular
    stores. May be involved in pre-B-cell growth
    Catalytic activity: NAD(+) + H(2)O = ADP-D-ribose + nicotinamide

         Genatlas biochemistry entry for BST1:
    bone marrow stromal antigens,involved in pre-B-cell growth,expressed in various tissues

         Enzyme Number (IUBMB): EC 3.2.2.51

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003953NAD+ nucleosidase activity IEA--
         
    Find genes that share ontologies with BST1           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Bst1):
     hematopoietic system  immune system 

    Find genes that share phenotypes with BST1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Bst1tm1Thir for BST1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BST1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BST1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BST1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BST1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat BST1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate BST1:
    hsa-miR-103a-2*
    SwitchGear 3'UTR luciferase reporter plasmidBST1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BST1
    Predesigned siRNA for gene silencing in human, mouse, rat BST1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BST1

    Clone
    Products:
         
    OriGene clones in human, mouse for BST1 (see all 8)
    OriGene ORF clones in mouse, rat for BST1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BST1 (NM_004334)
    Sino Biological Human cDNA Clone for BST1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BST1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BST1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for BST1
    Browse ESI BIO Cell Lines and PureStem Progenitors for BST1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BST1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    BST1_HUMAN, Q10588: Cell membrane; Lipid-anchor, GPI-anchor
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular3
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0019898extrinsic component of membrane TAS8202488
    GO:0031225anchored component of membrane IEA--

    Find genes that share ontologies with BST1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for BST1 About    
    See pathways by source

    SuperPathContained pathways About
    1Nicotinate and nicotinamide metabolism
    Nicotinate and nicotinamide metabolism0.43
    NAD metabolism0.43
    2Salivary secretion
    Salivary secretion0.34
    3Pancreatic secretion
    Pancreatic secretion


    Find genes that share SuperPaths with BST1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for BST1
        NAD metabolism



    3 Kegg Pathways  (Kegg details for BST1):
        Nicotinate and nicotinamide metabolism
    Salivary secretion
    Pancreatic secretion

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BST1
    Interactions:

        Search GeneGlobe Interaction Network for BST1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for BST1 (Q105883 ENSP000002650164) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAV1Q031353, ENSP000003391914I2D: score=1 STRING: ENSP00000339191
    CD38ENSP000002262794STRING: ENSP00000226279
    ENPP1ENSP000003542384STRING: ENSP00000354238
    ENPP3ENSP000003502654STRING: ENSP00000350265
    NADKENSP000003416794STRING: ENSP00000341679
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006959humoral immune response TAS8202488
    GO:0007275multicellular organismal development TAS8202488

    Find genes that share ontologies with BST1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BST1

    8 HMDB Compounds for BST1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADP-ribose 2'-phosphate2'-phosphoadenosine 5'-[3-(D-ribofuranosyl) dihydrogen diphosphate] (see all 3)26303-90-2--
    Adenosine diphosphate ribose(Rib5)ppA (see all 13)20762-30-5--
    CalciumCa (see all 2)7440-70-2--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    Niacinamide3-Carbamoylpyridine (see all 77)98-92-0--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    5 DrugBank Compounds for BST1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine-5'-Diphosphate Monothiophosphate-- --target--17139284 17016423
    Etheno-Nad-- --target--17139284 17016423
    Etheno-Nadp-- --target--17139284 17016423
    Nicotinamide-- 98-92-0target--17139284 17016423
    Nicotinamide Mononucleotide-- --target--17139284 17016423

    4 Novoseek inferred chemical compound relationships for BST1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclic adp-ribose 89 8 8645283 (2), 9895292 (1), 18626062 (1), 9030974 (1)
    nad+ 71.1 13 19052657 (2), 12415565 (1), 18626062 (1), 18019526 (1)
    retinoic acid 16.9 3 12139742 (1), 11089918 (1)
    calcium 8.35 4 9895292 (1), 17380196 (1)



    Find genes that share compounds with BST1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for BST1 gene: 
    NM_004334.2  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265016(uc003goh.4) ENST00000382346 ENST00000505785 ENST00000514445
    ENST00000514989
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat BST1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate BST1:
    hsa-miR-103a-2*
    SwitchGear 3'UTR luciferase reporter plasmidBST1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for BST1
    Predesigned siRNA for gene silencing in human, mouse, rat BST1
    Clone
    Products:
         
    OriGene clones in human, mouse for BST1 (see all 8)
    OriGene ORF clones in mouse, rat for BST1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BST1 (NM_004334)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BST1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BST1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for BST1
    OriGene qSTAR qPCR primer pairs in human, mouse for BST1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BST1
      QuantiTect SYBR Green Assays in human, mouse, rat BST1
      QuantiFast Probe-based Assays in human, mouse, rat BST1

    Selected AceView cDNA sequences (see all 67):

    CR603536 AL599287 BU732655 AI266729 BX103493 BP375001 BI908623 AI825103 
    BQ018460 CD369441 AI091431 BF901938 H80057 AI473404 AA345101 AI183436 
    AI140774 AI468648 AW950679 BX443941 AA557150 BU626933 N39926 AL700932 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    BST1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCGCCGCG
    BST1 Expression
    About this image


    BST1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Monocytes Peripheral Blood
     
     Liver (Hepatobiliary System)
             Mature Mesothelial Cells Hepatic Mesenchyme
     
     Endothelium (Cardiovascular System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Brain (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier
    BST1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BST1 Protein Expression

    UniProtKB/Swiss-Prot: BST1_HUMAN, Q10588
    Tissue specificity: Widely expressed

        Custom PCR Arrays for BST1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for BST1
    OriGene qSTAR qPCR primer pairs in human, mouse for BST1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BST1
    QuantiTect SYBR Green Assays in human, mouse, rat BST1
    QuantiFast Probe-based Assays in human, mouse, rat BST1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BST1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for BST1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bst11 , 5 bone marrow stromal cell antigen 11, 5 79.21(n)1
    74.91(a)1
      5 (23.84 cM)5
    121821  NM_009763.31  NP_033893.21 
     438188865 
    chicken
    (Gallus gallus)
    Aves BST11 bone marrow stromal cell antigen 1 64.61(n)
    54.44(a)
      422828  NM_001200043.1  NP_001186972.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia bst11 bone marrow stromal cell antigen 1 57.98(n)
    50.58(a)
      101733556  XM_004911233.1  XP_004911290.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CR318624.16
    Uncharacterized protein
    34(a)
    1 → many
    24(8806391-8815691) ENSDARG00000086451


    ENSEMBL Gene Tree for BST1 (if available)
    TreeFam Gene Tree for BST1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for BST1 gene
    CD382  
    1 SIMAP similar gene for BST1 using alignment to 6 protein entries:     BST1_HUMAN (see all proteins):
    CD38

    Find genes that share paralogs with BST1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for BST1 (see all 717)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs76903621,2
    C,F,A,H--15702697(+) acctgT/Agacct 1 -- us2k110Minor allele frequency- A:0.18NA WA CSA 17
    rs2011844731,2
    --15703070(+) TACAG-/AAAAAA 1 -- us2k10--------
    rs174061281,2
    C,F,H--15703135(+) CAAGTG/ACTTGC 1 -- us2k1 tfbs39Minor allele frequency- A:0.04NA EA NS WA 774
    rs1136183201,2
    C--15703258(+) ACTCTG/TTTGCC 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1449880601,2
    --15703443(+) GTCTCA/GATCTC 1 -- us2k10--------
    rs76969381,2
    C,F,A,H--15703577(+) AGGGAG/TATTGT 1 -- us2k132Minor allele frequency- T:0.27NS EA NA WA CSA 2900
    rs1149922031,2
    F--15703607(+) TCGGCG/AGTAGG 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1434036331,2
    --15703740(+) TCCAGA/GTTCCT 1 -- us2k10--------
    rs1466818731,2
    --15703878(+) ATGTTC/TCTCAT 1 -- us2k10--------
    rs1928659801,2
    --15703903(+) ATTTGA/GATGAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for BST1 (15704573 - 15739936 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for BST1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv27101CNV Loss19812545
    nsv822495CNV Loss20364138
    nsv10459CNV Loss18304495
    dgv864n67CNV Loss20364138
    nsv428439CNV Gain+Loss18775914
    dgv1587e1CNV Complex17122850
    dgv1586e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): BST1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BST1
    DNA2.0 Custom Variant and Variant Library Synthesis for BST1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600387    OMIM disorders: --

    2 diseases for BST1:    
    About MalaCards
    rheumatoid arthritis    arthritis


    Find genes that share disorders with BST1           About GenesLikeMe

    3 Novoseek inferred disease relationships for BST1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paroxysmal hemoglobinuria nocturnal 58.1 1 15328157 (1)
    leukemia 22.6 1 11528102 (1)
    rheumatoid arthritis 3.59 3 8630113 (2)

    Genetic Association Database (GAD): BST1
    Human Genome Epidemiology (HuGE) Navigator: BST1 (10 documents)

    Export disorders for BST1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for BST1 gene, integrated from 10 sources (see all 60):
    (articles sorted by number of sources associating them with BST1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. BST-1, a surface molecule of bone marrow stromal cell lines that facilitates pre-B-cell growth. (PubMed id 8202488)1, 2, 3 Kaisho T.... Hirano T. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    2. Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities. (PubMed id 11866528)1, 2, 9 Yamamoto-Katayama S....Morikawa K. (J. Mol. Biol. 2002)
    3. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. (PubMed id 21292315)1, 4  ....Wood N.W. (Lancet 2011)
    4. Analysis of GWAS-linked loci in Parkinson disease reaffirms PARK16 as a susceptibility locus. (PubMed id 20697102)1, 4 Tan E.K....Liu J.J. (Neurology 2010)
    5. Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease. (PubMed id 20711177)1, 4 Hamza T.H....Payami H. (Nat. Genet. 2010)
    6. Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. (PubMed id 19915576)1, 4 Satake W....Toda T. (Nat. Genet. 2009)
    7. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. CD157 is an important mediator of neutrophil adhesion and migration. (PubMed id 15328157)1, 9 Funaro A....Malavasi F. (Blood 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 683 HGNC: 1118 AceView: BST1 Ensembl:ENSG00000109743 euGenes: HUgn683
    ECgene: BST1 Kegg: 683 H-InvDB: BST1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for BST1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for BST1 gene:
    Search GeneIP for patents involving BST1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for BST1 (CD157)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for BST1 (CD157)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for BST1   OriGene RNAi products in human, mouse, rat for BST1  
     OriGene qPCR primer pairs and template standards for BST1   OriGene Protein Over-expression Lysate for BST1  
     OriGene MassSpec something-or-other for BST1   OriGene clones in human, mouse for BST1  
     OriGene qSTAR qPCR primer pairs in human, mouse for BST1   OriGene Purified Protein for BST1  
     OriGene ORF clones in mouse, rat for BST1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for BST1   OriGene Custom Protein Services for BST1  

     
     
     Block miRNA regulation of human, mouse, rat BST1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing BST1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BST1 Predesigned siRNA for gene silencing in human, mouse, rat BST1
     QuantiFast Probe-based Assays in human, mouse, rat BST1 QuantiTect SYBR Green Assays in human, mouse, rat BST1
     Custom PCR Arrays for BST1 Search Chromatin IP Primers for BST1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BST1  Search GeneGlobe Interaction Network for BST1
     Search Regulatory tfbs for BST1
     GenScript Custom Purified and Recombinant Proteins Services for BST1 GenScript cDNA clones with any tag delivered in your preferred vector for BST1
     GenScript Custom Assay Services for BST1 GenScript Custom overexpressing Cell Line Services for BST1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for BST1
     Proteins for BST1
     Cell Lysates for BST1
     cDNA Clones for BST1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     BST1 antibodies
     BST1 proteins
     BST1 lysates
     Antibodies for BST1
     See all of Abcam's Antibodies, Kits and Proteins for BST1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for BST1
     Antibodies for BST1
     ELISAs for BST1
     CLIAs for BST1



     Browse ESI BIO Cell Lines and PureStem Progenitors for BST1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BST1
     SwitchGear 3'UTR luciferase reporter plasmids for BST1
     SwitchGear Promoter luciferase reporter plasmids for BST1
     ThermoFisher Antibodies for BST1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BST1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BST1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BST1
     LSBio Antibodies in human, mouse, rat for BST1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for BST1
      Search eBioscience for proteins for BST1
      Search eBioscience for elisas for BST1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      BST1 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4