BSPRY Gene
protein-coding GIFtS: 49
GCID: GC09P116111
|
|
B-box and SPRY domain containing
| |
Aliases
for BSPRY gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| B-Box And SPRY Domain Containing1 2 | | FLJ201501 | | B Box And SPRY Domain-Containing Protein2 | | B-Box And SPRY-Domain Containing Protein2 | | Zetin 12 |
Export aliases for BSPRY gene to outside databasesPrevious GC identifers: GC09P107843 GC09P109565 GC09P111487 GC09P113191 GC09P115151 GC09P085719 |
Summaries
for BSPRY gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: BSPRY_HUMAN, Q5W0U4Function: May regulate epithelial calcium transport by inhibiting TRPV5 activity (By similarity)
|
Genomic Views
for BSPRY gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BSPRY gene promoter:
c-Fos AP-1 NF-kappaB Max NF-kappaB2 HFH-1 FOXO1a c-Jun NF-kappaB1 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for BSPRY
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BSPRY |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q32 Ensembl cytogenetic band: 9q32 HGNC cytogenetic band: 9q33.1BSPRY Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P116111: view genomic region
(about GC identifiers)
Start:
|
116,111,812 bp from pter |
End:
|
116,133,513 bp from pter |
Size:
|
21,702 bases |
Orientation:
|
plus strand |
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Proteins
for BSPRY gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BSPRY_HUMAN, Q5W0U4 (See
protein sequence)Recommended Name: B box and SPRY domain-containing protein Size: 402 amino acids; 44381 Da
Subunit: Interacts with TRPV5 and TRPV6. Interacts with YWHAZ/14-3-3 protein zeta (By similarity)
Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein (By similarity)
Sequence caution: Sequence=BAA90980.1; Type=Erroneous initiation;
Secondary accessions: B3KS19 Q96DJ2 Q9H4E4 Q9NXN0Alternative splicing: 2 isoforms: Q5W0U4-1 Q5W0U4-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for BSPRY: NX_Q5W0U4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5W0U4
BSPRY Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060158.2
ENSEMBL proteins: ENSP00000363298
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
BSPRY for ontologies About GeneDecksing
BSPRY Antibody Products:
Assay Products for BSPRY: |
Protein
Domains /
Families
for BSPRY gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BSPRY for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q5W0U4ProtoNet protein and cluster: Q5W0U4 3 Blocks protein families: IPB000315 B-box zinc finger signature IPB003879 Butyrophylin C-terminal DUF signature IPB006574 SPRY-associated domain
UniProtKB/Swiss-Prot: BSPRY_HUMAN, Q5W0U4Similarity: Contains 1 B box-type zinc fingerSimilarity: Contains 1 B30.2/SPRY domain |
Function
for BSPRY gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: BSPRY_HUMAN, Q5W0U4Function: May regulate epithelial calcium transport by inhibiting TRPV5 activity (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BSPRY (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BSPRY (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: BSPRY (NM_017688) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BSPRY | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BSPRY |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BSPRY |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
BSPRY for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for BSPRY:
Animal Models:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Bspry):
BSPRY for phenotypes About GeneDecksing
|
Pathways & Interactions
for BSPRY gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BSPRY
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for BSPRY (Q5W0U43 ENSP000003632984) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006816 | calcium ion transport |
IEA | -- |
BSPRY for ontologies About GeneDecksing
|
Drugs & Compounds
for BSPRY gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BSPRY
1 HMDB Compound for BSPRY About this table
Search CenterWatch for drugs/clinical trials and news about BSPRY
|
Transcripts
for BSPRY gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BSPRY gene: NM_017688.2 Unigene Cluster for BSPRY: B-box and SPRY domain containing Hs.614517 [show with all ESTs]Unigene Representative Sequence: NM_0176882 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000374183(uc004bhg.4 uc010muw.3) ENST00000462085
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BSPRY (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BSPRY (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: BSPRY (NM_017688) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BSPRY | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BSPRY |
Additional cDNA sequence: AJ276691.1 AK000157.1 AK092607.1 BC001477.2 6 DOTS entries: DT.92451336 DT.92451339 DT.97839325 DT.100754196 DT.92042114 DT.91786817 24/104 AceView cDNA sequences (see all 104): AA829350 AI207240 AK092607 BF590829 CD676101 CR603733 AI278908 AA569126 AA639547 BP370567 AA551900 AW237259 AI951830 AW204328 BX106172 AI279588 CA450456 AI804376 AI028473 BC001477 BU726988 AA772358 BM794941 AA372012
GeneLoc Exon Structure
|
Expression
for BSPRY gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BSPRY expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTCCAGGTA
About this image
See BSPRY Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BSPRY
SOURCE GeneReport for Unigene cluster: Hs.614517
SABiosciences Custom PCR Arrays for BSPRY
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BSPRY
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BSPRY | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BSPRY | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BSPRY | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BSPRY |
Orthologs
for BSPRY gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for BSPRY gene from 3/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
BSPRY1 |
B-box and SPRY domain containing |
68.86(n)
63.32(a) |
|
417272 XM_415546.3 XP_415546.3 |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.162952 |
Transcribed sequence with weak similarity to protein more |
75(n) |
|
142030668 |
zebrafish
(Danio rerio) |
Actinopterygii |
bspry1 |
B-box and SPRY domain containing |
50.35(n)
42.45(a) |
|
559377 XM_682712.5 XP_687804.3 |
ENSEMBL Gene Tree for BSPRY (if available)
TreeFam Gene Tree for BSPRY (if available) |
Paralogs
for BSPRY gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BSPRY gene
- TRIM142
BSPRY for paralogs About GeneDecksing
|
Genomic Variants
for BSPRY gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BSPRY (116111812 - 116133513 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for BSPRY
1 Indel: 59505 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BSPRY |
|
Disorders
/ Diseases
for BSPRY gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BSPRY for disorders About GeneDecksing
4  diseases for BSPRY: About MalaCardscleft lip/palate cleft lip parathyroid adenoma adenoma
1 disease from the University of Copenhagen DISEASES database for BSPRY:Parathyroid adenoma Human Genome Epidemiology (HuGE) Navigator: BSPRY (1 document)
Export disorders for BSPRY gene to outside databases
|
Publications
for BSPRY gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BSPRY gene integrated from 9 sources:
(articles sorted by number of sources associating them with BSPRY) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- BSPRY, a novel protein of the Ro-Ret family. (PubMed id 10978534)1, 2, 3 Schenker T. and Trueb B. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- Interaction of the type IIa Na/Pi cotransporter with PDZ proteins. (PubMed id 11099500)1, 3 Gisler S.M....Murer H. (2001)
- Searching for genes for cleft lip and/or palate based on breakpoint analysis of a balanced translocation t(9;17)(q32;q12). (PubMed id 19929093)1, 9 Machida J....Ono T. (2009)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Characterization of zetin 1/rBSPRY, a novel binding partner of 14-3-3 proteins. (PubMed id 12615066)1 Birkenfeld J....Roth D. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for BSPRY gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing BSPRY gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BSPRY gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BSPRY gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for BSPRY | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for BSPRY gene:
Search GeneIP for patents involving BSPRY
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BSPRY gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for BSPRY | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BSPRY | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BSPRY | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BSPRY | | OriGene 3'-UTR Clone for BSPRY | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BSPRY | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BSPRY | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for BSPRY | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for BSPRY | | OriGene Custom Protein Services for BSPRY | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BSPRY | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BSPRY | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BSPRY | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BSPRY | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BSPRY | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BSPRY |
| |
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| |  |  |  |  | | | | |
 |
 |
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 | | | BSPRY Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BSPRY |
|  |  |  | | | | ThermoFisher Antibodies for BSPRY |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BSPRY |
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