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Aliases for BSPRY Gene

Aliases for BSPRY Gene

  • B-Box And SPRY Domain Containing 2 3

External Ids for BSPRY Gene

Summaries for BSPRY Gene

GeneCards Summary for BSPRY Gene

BSPRY (B-Box And SPRY Domain Containing) is a Protein Coding gene. An important paralog of this gene is SPRYD4.

UniProtKB/Swiss-Prot for BSPRY Gene

  • May regulate epithelial calcium transport by inhibiting TRPV5 activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BSPRY Gene

Genomics for BSPRY Gene

Genomic Location for BSPRY Gene

Start:
113,349,532 bp from pter
End:
113,371,233 bp from pter
Size:
21,702 bases
Orientation:
Plus strand

Genomic View for BSPRY Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BSPRY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BSPRY Gene

Regulatory Elements for BSPRY Gene

Proteins for BSPRY Gene

  • Protein details for BSPRY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5W0U4-BSPRY_HUMAN
    Recommended name:
    B box and SPRY domain-containing protein
    Protein Accession:
    Q5W0U4
    Secondary Accessions:
    • B3KS19
    • Q96DJ2
    • Q9H4E4
    • Q9NXN0

    Protein attributes for BSPRY Gene

    Size:
    402 amino acids
    Molecular mass:
    44381 Da
    Quaternary structure:
    • Interacts with TRPV5 and TRPV6. Interacts with YWHAZ/14-3-3 protein zeta (By similarity).
    SequenceCaution:
    • Sequence=BAA90980.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for BSPRY Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BSPRY Gene

Proteomics data for BSPRY Gene at MOPED

Post-translational modifications for BSPRY Gene

No Post-translational modifications

Other Protein References for BSPRY Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BSPRY Gene

Domains for BSPRY Gene

UniProtKB/Swiss-Prot:

BSPRY_HUMAN
Domain:
  • Contains 1 B30.2/SPRY domain.:
    • Q5W0U4
Similarity:
  • Contains 1 B box-type zinc finger.:
    • Q5W0U4
genes like me logo Genes that share domains with BSPRY: view

No data available for Gene Families for BSPRY Gene

Function for BSPRY Gene

Molecular function for BSPRY Gene

UniProtKB/Swiss-Prot Function: May regulate epithelial calcium transport by inhibiting TRPV5 activity.

Gene Ontology (GO) - Molecular Function for BSPRY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with BSPRY: view

Phenotypes for BSPRY Gene

MGI mutant phenotypes for BSPRY:
inferred from 1 alleles
GenomeRNAi human phenotypes for BSPRY:
genes like me logo Genes that share phenotypes with BSPRY: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BSPRY Gene

Localization for BSPRY Gene

Subcellular locations from UniProtKB/Swiss-Prot for BSPRY Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BSPRY Gene COMPARTMENTS Subcellular localization image for BSPRY gene
Compartment Confidence
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for BSPRY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005925 focal adhesion IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with BSPRY: view

Pathways for BSPRY Gene

SuperPathways for BSPRY Gene

No Data Available

Interacting Proteins for BSPRY Gene

Gene Ontology (GO) - Biological Process for BSPRY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006816 calcium ion transport IEA --
genes like me logo Genes that share ontologies with BSPRY: view

No data available for Pathways by source for BSPRY Gene

Compounds for BSPRY Gene

(1) HMDB Compounds for BSPRY Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with BSPRY: view

Transcripts for BSPRY Gene

Unigene Clusters for BSPRY Gene

B-box and SPRY domain containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BSPRY Gene

No ASD Table

Relevant External Links for BSPRY Gene

GeneLoc Exon Structure for
BSPRY
ECgene alternative splicing isoforms for
BSPRY

Expression for BSPRY Gene

mRNA expression in normal human tissues for BSPRY Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BSPRY Gene

This gene is overexpressed in Pancreas (6.0) and Esophagus - Mucosa (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BSPRY Gene

SOURCE GeneReport for Unigene cluster for BSPRY Gene Hs.614517

genes like me logo Genes that share expressions with BSPRY: view

Orthologs for BSPRY Gene

This gene was present in the common ancestor of chordates.

Orthologs for BSPRY Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BSPRY 36
  • 99.25 (n)
  • 99.25 (a)
BSPRY 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BSPRY 36
  • 88.2 (n)
  • 89.53 (a)
BSPRY 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BSPRY 36
  • 86.35 (n)
  • 88.72 (a)
BSPRY 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bspry 36
  • 83.33 (n)
  • 80.89 (a)
Bspry 16
Bspry 37
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BSPRY 37
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BSPRY 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bspry 36
  • 82.41 (n)
  • 78.74 (a)
chicken
(Gallus gallus)
Aves BSPRY 36
  • 68.86 (n)
  • 63.32 (a)
BSPRY 37
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bspry 36
  • 64.56 (n)
  • 58.47 (a)
Str.16295 36
zebrafish
(Danio rerio)
Actinopterygii bspry 36
  • 50.44 (n)
  • 42.63 (a)
bspry 37
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 16 (a)
OneToMany
Species with no ortholog for BSPRY:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BSPRY Gene

ENSEMBL:
Gene Tree for BSPRY (if available)
TreeFam:
Gene Tree for BSPRY (if available)

Paralogs for BSPRY Gene

Paralogs for BSPRY Gene

genes like me logo Genes that share paralogs with BSPRY: view

Variants for BSPRY Gene

Sequence variations from dbSNP and Humsavar for BSPRY Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs10673 -- 113,371,073(+) CTTTT(C/G)TCTTA utr-variant-3-prime
rs752757 -- 113,360,674(-) TCAAG(C/G/T)TTCTG reference, missense, synonymous-codon, intron-variant
rs752758 -- 113,360,207(-) TGCTT(A/T)ATCAC intron-variant
rs818709 -- 113,369,023(+) CTCCT(C/T)GTATT intron-variant
rs818710 -- 113,369,173(+) GGACA(A/C)GTCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BSPRY Gene

Variant ID Type Subtype PubMed ID
nsv893744 CNV Gain 21882294
nsv519849 CNV Gain 19592680
esv2657221 CNV Deletion 23128226
nsv819179 CNV Gain 19587683

Relevant External Links for BSPRY Gene

HapMap Linkage Disequilibrium report
BSPRY

Disorders for BSPRY Gene

(1) University of Copenhagen DISEASES for BSPRY Gene

Relevant External Links for BSPRY

Genetic Association Database (GAD)
BSPRY
Human Genome Epidemiology (HuGE) Navigator
BSPRY
genes like me logo Genes that share disorders with BSPRY: view

No data available for UniProtKB/Swiss-Prot for BSPRY Gene

Publications for BSPRY Gene

  1. Searching for genes for cleft lip and/or palate based on breakpoint analysis of a balanced translocation t(9;17)(q32;q12). (PMID: 19929093) Machida J. … Ono T. (Cleft Palate Craniofac. J. 2009) 3 23 49
  2. BSPRY, a novel protein of the Ro-Ret family. (PMID: 10978534) Schenker T. … Trueb B. (Biochim. Biophys. Acta 2000) 2 3 4
  3. Interaction of the type IIa Na/Pi cotransporter with PDZ proteins. (PMID: 11099500) Gisler S.M. … Murer H. (J. Biol. Chem. 2001) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4

Products for BSPRY Gene

Sources for BSPRY Gene

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