BSPH1 Gene
protein-coding GIFtS: 34
GCID: GC19M048471
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|
binder of sperm protein homolog 1
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Aliases
for BSPH1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Binder Of Sperm Protein Homolog 11 2 | | Bovine Seminal Plasma Protein-Like 12 3 | | BSP11 2 | | Binder Of Sperm 12 | | ELSPBP21 2 | | Epididymal Sperm Binding Protein 22 | | Bovine Seminal Plasma Protein Homolog 12 3 | | |
Export aliases for BSPH1 gene to outside databasesPrevious GC identifers: GC19M053163 GC19M044853 |
Summaries
for BSPH1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: BSPH1_HUMAN, Q075Z2Function: May play a role in sperm capacitation
|
Genomic Views
for BSPH1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BSPH1 gene promoter:
Nkx3-1 Nkx3-1 v4 GR-beta POU3F1 Nkx3-1 v1 GATA-1 GATA-2 Nkx3-1 v2 Nkx3-1 v3 GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for BSPH1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BSPH1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.33 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.32BSPH1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M048471: view genomic region
(about GC identifiers)
Start:
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48,471,303 bp from pter |
End:
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48,495,427 bp from pter |
Size:
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24,125 bases |
Orientation:
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minus strand |
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Proteins
for BSPH1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BSPH1_HUMAN, Q075Z2 (See
protein sequence)Recommended Name: Binder of sperm protein homolog 1 precursor Size: 132 amino acids; 15693 Da
Subcellular location: Secreted (Probable)
Secondary accessions: A6NIZ5Explore the universe of human proteins at neXtProt for BSPH1: NX_Q075Z2
BSPH1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001121798.1
ENSEMBL proteins: ENSP00000341762
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
BSPH1 for ontologies About GeneDecksing
BSPH1 Antibody Products:
Assay Products for BSPH1: |
Protein
Domains /
Families
for BSPH1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BSPH1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q075Z2ProtoNet protein and cluster: Q075Z2 1 Blocks protein family: IPB000562 Type II fibronectin collagen-binding domain
UniProtKB/Swiss-Prot: BSPH1_HUMAN, Q075Z2Similarity: Belongs to the seminal plasma protein familySimilarity: Contains 2 fibronectin type-II domains |
Function
for BSPH1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: BSPH1_HUMAN, Q075Z2Function: May play a role in sperm capacitation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BSPH1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BSPH1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: BSPH1 (NM_001128326) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BSPH1 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat BSPH1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BSPH1 |
|
Pathways & Interactions
for BSPH1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BSPH1
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007338 | single fertilization |
IEA | -- |
BSPH1 for ontologies About GeneDecksing
|
Drugs & Compounds
for BSPH1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BSPH1
Search CenterWatch for drugs/clinical trials and news about BSPH1
|
Transcripts
for BSPH1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BSPH1 gene: NM_001128326.2 Unigene Cluster for BSPH1: Binder of sperm protein homolog 1 Hs.651072 Unigene Representative Sequence: DQ2274971 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000344839(uc002phs.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BSPH1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BSPH1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: BSPH1 (NM_001128326) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BSPH1 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat BSPH1 |
Additional cDNA sequence: DQ227497.1
GeneLoc Exon Structure
|
Expression
for BSPH1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BSPH1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATTCTTCAG
About this image
See BSPH1 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.651072
UniProtKB/Swiss-Prot: BSPH1_HUMAN, Q075Z2Tissue specificity: Expressed only in the epididymis
SABiosciences Custom PCR Arrays for BSPH1
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BSPH1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BSPH1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BSPH1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BSPH1 |
Orthologs
for BSPH1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for BSPH1 gene from 1/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
35(a) |
1 ↔ 1 |
GL343253.1(224859-226632) |
ENSEMBL Gene Tree for BSPH1 (if available)
TreeFam Gene Tree for BSPH1 (if available) |
Paralogs
for BSPH1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BSPH1 gene
- ELSPBP12
2 SIMAP similar genes for BSPH1 using alignment to 1 protein entry: BSPH1_HUMAN:ELSPBP1 FN1
BSPH1 for paralogs About GeneDecksing
|
Genomic Variants
for BSPH1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BSPH1 (48471303 - 48495427 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for BSPH1
4 CNVs: 35659 0517 5105 32261 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BSPH1 |
|
Disorders
/ Diseases
for BSPH1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BSPH1 for disorders About GeneDecksing
OMIM gene information: 612213
OMIM disorders: --
7  diseases for BSPH1: About MalaCardsepididymitis cutaneous mastocytosis diffuse cutaneous mastocytosis mastocytosis
chronic myeloid leukemia myeloid leukemia leukemia
Export disorders for BSPH1 gene to outside databases
|
Publications
for BSPH1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BSPH1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with BSPH1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Genomic structure and tissue-specific expression of human and mouse genes encoding homologues of the major bovine seminal plasma proteins. (PubMed id 17085770)1, 2, 3 Lefebvre J....Manjunath P. (2007)
- New Nomenclature for Mammalian BSP Genes. (PubMed id 18923155)1, 3 Manjunath P....Wright M.W. (2008)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
- Recombinant expression and affinity purification of a novel epididymal human sperm-binding protein, BSPH1. (PubMed id 19091820)1 Lefebvre J....Manjunath P. (2009)
|
External Searches for BSPH1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing BSPH1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BSPH1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BSPH1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for BSPH1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for BSPH1 gene:
Search GeneIP for patents involving BSPH1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BSPH1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for BSPH1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BSPH1 | | Browse OriGene genome-wide validated SYBR primer pairs | | | OriGene Protein Over-expression Lysate for BSPH1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BSPH1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BSPH1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BSPH1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for BSPH1 | | OriGene Custom Protein Services for BSPH1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BSPH1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BSPH1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BSPH1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BSPH1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BSPH1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BSPH1 |
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| | | | Search Tocris compounds for BSPH1 |
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 | | | BSPH1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BSPH1 |
|  |  |  | | | | Search ThermoFisher Antibodies for BSPH1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat BSPH1 |
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