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Aliases for BSPH1 Gene

Aliases for BSPH1 Gene

  • Binder Of Sperm Protein Homolog 1 2 3 5
  • Bovine Seminal Plasma Protein Homolog 1 2 3 4
  • Bovine Seminal Plasma Protein-Like 1 3 4
  • Epididymal Sperm Binding Protein 2 2 3
  • Binder Of Sperm 1 3
  • ELSPBP2 3
  • BSP1 3

External Ids for BSPH1 Gene

Previous GeneCards Identifiers for BSPH1 Gene

  • GC19M053163
  • GC19M048471
  • GC19M044853

Summaries for BSPH1 Gene

GeneCards Summary for BSPH1 Gene

BSPH1 (Binder Of Sperm Protein Homolog 1) is a Protein Coding gene. GO annotations related to this gene include heparin binding.

UniProtKB/Swiss-Prot for BSPH1 Gene

  • Binds sperm in vitro and promotes sperm capacitation. Specifically promotes capacitation induced by high density lipoproteins (HDLs). Also binds heparin, phospholipid liposomes, and weakly to gelatin. Does not bind chondroitin sulfate B.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BSPH1 Gene

Genomics for BSPH1 Gene

Regulatory Elements for BSPH1 Gene

Genomic Location for BSPH1 Gene

Chromosome:
19
Start:
47,968,046 bp from pter
End:
47,992,170 bp from pter
Size:
24,125 bases
Orientation:
Minus strand

Genomic View for BSPH1 Gene

Genes around BSPH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BSPH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BSPH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BSPH1 Gene

Proteins for BSPH1 Gene

  • Protein details for BSPH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q075Z2-BSPH1_HUMAN
    Recommended name:
    Binder of sperm protein homolog 1
    Protein Accession:
    Q075Z2
    Secondary Accessions:
    • A6NIZ5

    Protein attributes for BSPH1 Gene

    Size:
    132 amino acids
    Molecular mass:
    15693 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BSPH1 Gene

Proteomics data for BSPH1 Gene at MOPED

Post-translational modifications for BSPH1 Gene

  • Glycosylation at Asn 53
  • Modification sites at PhosphoSitePlus

Other Protein References for BSPH1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BSPH1 Gene

Domains & Families for BSPH1 Gene

Protein Domains for BSPH1 Gene

Suggested Antigen Peptide Sequences for BSPH1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q075Z2

UniProtKB/Swiss-Prot:

BSPH1_HUMAN :
  • Contains 2 fibronectin type-II domains.
  • Belongs to the seminal plasma protein family.
Domain:
  • Contains 2 fibronectin type-II domains.
Family:
  • Belongs to the seminal plasma protein family.
genes like me logo Genes that share domains with BSPH1: view

No data available for Gene Families for BSPH1 Gene

Function for BSPH1 Gene

Molecular function for BSPH1 Gene

UniProtKB/Swiss-Prot Function:
Binds sperm in vitro and promotes sperm capacitation. Specifically promotes capacitation induced by high density lipoproteins (HDLs). Also binds heparin, phospholipid liposomes, and weakly to gelatin. Does not bind chondroitin sulfate B.

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BSPH1 Gene

Localization for BSPH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BSPH1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BSPH1 Gene COMPARTMENTS Subcellular localization image for BSPH1 gene
Compartment Confidence
extracellular 5
cytosol 2
mitochondrion 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for BSPH1 Gene

Pathways & Interactions for BSPH1 Gene

SuperPathways for BSPH1 Gene

No Data Available

Interacting Proteins for BSPH1 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000341762%0d%0a9606.ENSP00000287814%0d%0a9606.ENSP00000266085%0d%0a9606.ENSP00000262768%0d%0a9606.ENSP00000218388%0d%0a
Selected Interacting proteins: ENSP00000341762 for BSPH1 Gene via STRING

Gene Ontology (GO) - Biological Process for BSPH1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BSPH1 Gene

Drugs & Compounds for BSPH1 Gene

No Compound Related Data Available

Transcripts for BSPH1 Gene

mRNA/cDNA for BSPH1 Gene

(3) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for BSPH1 Gene

No ASD Table

Relevant External Links for BSPH1 Gene

GeneLoc Exon Structure for
BSPH1
ECgene alternative splicing isoforms for
BSPH1

Expression for BSPH1 Gene

mRNA expression in normal human tissues for BSPH1 Gene

mRNA differential expression in normal tissues according to GTEx for BSPH1 Gene

This gene is overexpressed in Brain - Cerebellum (x19.9), Brain - Cerebellar Hemisphere (x16.3), and Brain - Spinal cord (cervical c-1) (x4.0).

SOURCE GeneReport for Unigene cluster for BSPH1 Gene Hs.651072

mRNA Expression by UniProt/SwissProt for BSPH1 Gene

Q075Z2-BSPH1_HUMAN
Tissue specificity: Expressed only in the epididymis.
genes like me logo Genes that share expression patterns with BSPH1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for BSPH1 Gene

Orthologs for BSPH1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BSPH1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BSPH1 35
  • 78.76 (n)
  • 66.67 (a)
BSP1 36
  • 37 (a)
OneToMany
BSP3 36
  • 34 (a)
OneToMany
BSP5 36
  • 26 (a)
OneToMany
dog
(Canis familiaris)
Mammalia BSPH1 35
  • 77.3 (n)
  • 63.79 (a)
BSPH1 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bsph1 35
  • 71.79 (n)
  • 61.54 (a)
Bsph1 16
Bsph1 36
  • 50 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BSPH1 35
  • 98.48 (n)
  • 96.97 (a)
BSPH1 36
  • 97 (a)
OneToOne
Species with no ortholog for BSPH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BSPH1 Gene

ENSEMBL:
Gene Tree for BSPH1 (if available)
TreeFam:
Gene Tree for BSPH1 (if available)

Paralogs for BSPH1 Gene

(2) SIMAP similar genes for BSPH1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BSPH1: view

No data available for Paralogs for BSPH1 Gene

Variants for BSPH1 Gene

Sequence variations from dbSNP and Humsavar for BSPH1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1820689 -- 47,985,605(+) CGAGG(C/T)GGGCA intron-variant
rs1820690 -- 47,986,749(+) aaaaa(A/T)aaaat intron-variant
rs1834955 -- 47,984,784(+) GAAAC(C/T)AACTA intron-variant
rs1834956 -- 47,984,786(+) AACCA(A/C)CTATT intron-variant
rs1834957 -- 47,984,960(+) TACTC(A/G)GGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BSPH1 Gene

Variant ID Type Subtype PubMed ID
nsv428367 CNV Gain+Loss 18775914
nsv2513 CNV Loss 18451855
nsv9739 CNV Gain+Loss 18304495
nsv2515 CNV Insertion 18451855
nsv180 CNV Insertion 15895083
nsv833853 CNV Loss 17160897
nsv912216 CNV Loss 21882294
esv2718670 CNV Deletion 23290073
esv2660721 CNV Deletion 23128226

Variation tolerance for BSPH1 Gene

Gene Damage Index Score: 2.69; 46.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BSPH1 Gene

HapMap Linkage Disequilibrium report
BSPH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BSPH1 Gene

Disorders for BSPH1 Gene

Relevant External Links for BSPH1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BSPH1

No disorders were found for BSPH1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BSPH1 Gene

Publications for BSPH1 Gene

  1. Genomic structure and tissue-specific expression of human and mouse genes encoding homologues of the major bovine seminal plasma proteins. (PMID: 17085770) Lefebvre J. … Manjunath P. (Mol. Hum. Reprod. 2007) 2 3 4 67
  2. New nomenclature for mammalian BSP genes. (PMID: 18923155) Manjunath P. … Wright M.W. (Biol. Reprod. 2009) 2 3
  3. Implication of the human Binder of SPerm Homolog 1 (BSPH1) protein in capacitation. (PMID: 24435510) Plante G. … Manjunath P. (Mol. Hum. Reprod. 2014) 3
  4. Recombinant expression and affinity purification of a novel epididymal human sperm-binding protein, BSPH1. (PMID: 19091820) Lefebvre J. … Manjunath P. (Mol. Hum. Reprod. 2009) 3
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3

Products for BSPH1 Gene

Sources for BSPH1 Gene

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