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Aliases for BSPH1 Gene

Aliases for BSPH1 Gene

  • Binder Of Sperm Protein Homolog 1 2 3 5
  • Bovine Seminal Plasma Protein Homolog 1 2 3 4
  • Bovine Seminal Plasma Protein-Like 1 3 4
  • Epididymal Sperm Binding Protein 2 2 3
  • Binder Of Sperm 1 3
  • ELSPBP2 3
  • BSP1 3

External Ids for BSPH1 Gene

Previous GeneCards Identifiers for BSPH1 Gene

  • GC19M053163
  • GC19M048471
  • GC19M044853

Summaries for BSPH1 Gene

GeneCards Summary for BSPH1 Gene

BSPH1 (Binder Of Sperm Protein Homolog 1) is a Protein Coding gene. GO annotations related to this gene include heparin binding.

UniProtKB/Swiss-Prot for BSPH1 Gene

  • Binds sperm in vitro and promotes sperm capacitation. Specifically promotes capacitation induced by high density lipoproteins (HDLs). Also binds heparin, phospholipid liposomes, and weakly to gelatin. Does not bind chondroitin sulfate B.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BSPH1 Gene

Genomics for BSPH1 Gene

Regulatory Elements for BSPH1 Gene

Enhancers for BSPH1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F047991 0.3 FANTOM5 89.5 +0.8 811 0.2 HDGF ZNF263 ZSCAN18 MAZ SP3 NR2F1 MAX NFXL1 ZFHX2 ZNF366 ELSPBP1 BSPH1 GC19M047959
GH19F047741 0.4 ENCODE 13.5 +248.2 248249 5.0 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 ZC3H4 GLTSCR1 ENSG00000269321 GRWD1 SELENOW KDELR1 CCDC9 EHD2 TPRX2P ELSPBP1
GH19F047607 0.9 Ensembl ENCODE 13.5 +381.1 381084 6.9 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 FOS ENSG00000269321 CCDC9 KDELR1 TPRX2P ELSPBP1 ZNF541 LOC105372430 GLTSCR2-AS1 ZC3H4 GRWD1
GH19F048444 0.2 ENCODE 13.5 -453.6 -453605 2.3 HDGF ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF207 ZNF143 ENSG00000269321 GRWD1 KDELR1 TEAD2 EHD2 LOC105372430 ELSPBP1 TPRX2P NTF6A NTF6B
GH19F048462 0.5 ENCODE 13.5 -470.3 -470329 0.2 HDGF ATF1 ARNT CREB3L1 SIN3A DMAP1 ZNF2 ETS1 YY1 ZNF766 ENSG00000269321 GLTSCR1 TEAD2 GRWD1 EHD2 LOC105372430 ELSPBP1 NTF6B NTF6A TPRX2P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around BSPH1 on UCSC Golden Path with GeneCards custom track

Genomic Location for BSPH1 Gene

Chromosome:
19
Start:
47,968,046 bp from pter
End:
47,992,170 bp from pter
Size:
24,125 bases
Orientation:
Minus strand

Genomic View for BSPH1 Gene

Genes around BSPH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BSPH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BSPH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BSPH1 Gene

Proteins for BSPH1 Gene

  • Protein details for BSPH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q075Z2-BSPH1_HUMAN
    Recommended name:
    Binder of sperm protein homolog 1
    Protein Accession:
    Q075Z2
    Secondary Accessions:
    • A6NIZ5

    Protein attributes for BSPH1 Gene

    Size:
    132 amino acids
    Molecular mass:
    15693 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BSPH1 Gene

Post-translational modifications for BSPH1 Gene

  • Glycosylation at Asn 53
  • Modification sites at PhosphoSitePlus

Other Protein References for BSPH1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BSPH1 Gene

Domains & Families for BSPH1 Gene

Protein Domains for BSPH1 Gene

Suggested Antigen Peptide Sequences for BSPH1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q075Z2

UniProtKB/Swiss-Prot:

BSPH1_HUMAN :
  • Contains 2 fibronectin type-II domains.
  • Belongs to the seminal plasma protein family.
Domain:
  • Contains 2 fibronectin type-II domains.
Family:
  • Belongs to the seminal plasma protein family.
genes like me logo Genes that share domains with BSPH1: view

No data available for Gene Families for BSPH1 Gene

Function for BSPH1 Gene

Molecular function for BSPH1 Gene

UniProtKB/Swiss-Prot Function:
Binds sperm in vitro and promotes sperm capacitation. Specifically promotes capacitation induced by high density lipoproteins (HDLs). Also binds heparin, phospholipid liposomes, and weakly to gelatin. Does not bind chondroitin sulfate B.

Gene Ontology (GO) - Molecular Function for BSPH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008201 heparin binding IEA,IBA --
genes like me logo Genes that share ontologies with BSPH1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BSPH1 Gene

Localization for BSPH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BSPH1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BSPH1 Gene COMPARTMENTS Subcellular localization image for BSPH1 gene
Compartment Confidence
extracellular 5
cytosol 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for BSPH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0009986 cell surface IEA,IBA --
genes like me logo Genes that share ontologies with BSPH1: view

Pathways & Interactions for BSPH1 Gene

SuperPathways for BSPH1 Gene

No Data Available

Interacting Proteins for BSPH1 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000341762%0d%0a9606.ENSP00000218388%0d%0a9606.ENSP00000266085%0d%0a9606.ENSP00000262768%0d%0a9606.ENSP00000287814%0d%0a
Selected Interacting proteins: ENSP00000341762 for BSPH1 Gene via STRING

Gene Ontology (GO) - Biological Process for BSPH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007338 single fertilization IEA --
GO:0048240 sperm capacitation IEA,IBA --
genes like me logo Genes that share ontologies with BSPH1: view

No data available for Pathways by source and SIGNOR curated interactions for BSPH1 Gene

Transcripts for BSPH1 Gene

mRNA/cDNA for BSPH1 Gene

(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BSPH1 Gene

No ASD Table

Relevant External Links for BSPH1 Gene

GeneLoc Exon Structure for
BSPH1
ECgene alternative splicing isoforms for
BSPH1

Expression for BSPH1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BSPH1 Gene

mRNA differential expression in normal tissues according to GTEx for BSPH1 Gene

This gene is overexpressed in Brain - Cerebellum (x19.9), Brain - Cerebellar Hemisphere (x16.3), and Brain - Spinal cord (cervical c-1) (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of BSPH1 Gene:

BSPH1

SOURCE GeneReport for Unigene cluster for BSPH1 Gene:

Hs.651072

mRNA Expression by UniProt/SwissProt for BSPH1 Gene:

Q075Z2-BSPH1_HUMAN
Tissue specificity: Expressed only in the epididymis.
genes like me logo Genes that share expression patterns with BSPH1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for BSPH1 Gene

Orthologs for BSPH1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BSPH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BSPH1 34 35
  • 98.48 (n)
cow
(Bos Taurus)
Mammalia BSPH1 34
  • 78.76 (n)
BSP1 35
  • 37 (a)
OneToMany
BSP3 35
  • 34 (a)
OneToMany
BSP5 35
  • 26 (a)
OneToMany
dog
(Canis familiaris)
Mammalia BSPH1 34 35
  • 77.3 (n)
mouse
(Mus musculus)
Mammalia Bsph1 34 16 35
  • 71.79 (n)
Species where no ortholog for BSPH1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BSPH1 Gene

ENSEMBL:
Gene Tree for BSPH1 (if available)
TreeFam:
Gene Tree for BSPH1 (if available)

Paralogs for BSPH1 Gene

(2) SIMAP similar genes for BSPH1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BSPH1: view

No data available for Paralogs for BSPH1 Gene

Variants for BSPH1 Gene

Sequence variations from dbSNP and Humsavar for BSPH1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10401815 -- 47,972,563(+) catta(A/G)tttgc intron-variant
rs10404937 -- 47,976,597(+) AAAAA(A/C)AAAAA intron-variant
rs10405387 -- 47,976,775(+) TTTTT(C/T)CCAAA reference, synonymous-codon
rs10405393 -- 47,968,165(+) GCATC(A/G)ATCAT utr-variant-3-prime
rs10405761 -- 47,967,852(+) TTGCT(A/T)GGAAA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for BSPH1 Gene

Variant ID Type Subtype PubMed ID
dgv3609n100 CNV loss 25217958
esv2660721 CNV deletion 23128226
esv2718670 CNV deletion 23290073
esv3556498 CNV deletion 23714750
nsv1055235 CNV loss 25217958
nsv1058622 CNV gain 25217958
nsv1065730 CNV loss 25217958
nsv1125501 CNV deletion 24896259
nsv1160654 CNV deletion 26073780
nsv180 CNV insertion 15895083
nsv2513 CNV deletion 18451855
nsv2515 CNV insertion 18451855
nsv428367 CNV gain+loss 18775914
nsv833853 CNV loss 17160897
nsv9739 CNV gain+loss 18304495

Variation tolerance for BSPH1 Gene

Gene Damage Index Score: 2.69; 46.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BSPH1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BSPH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BSPH1 Gene

Disorders for BSPH1 Gene

Relevant External Links for BSPH1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BSPH1

No disorders were found for BSPH1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BSPH1 Gene

Publications for BSPH1 Gene

  1. Genomic structure and tissue-specific expression of human and mouse genes encoding homologues of the major bovine seminal plasma proteins. (PMID: 17085770) Lefebvre J. … Manjunath P. (Mol. Hum. Reprod. 2007) 2 3 4 64
  2. New nomenclature for mammalian BSP genes. (PMID: 18923155) Manjunath P. … Wright M.W. (Biol. Reprod. 2009) 2 3 64
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  4. Implication of the human Binder of SPerm Homolog 1 (BSPH1) protein in capacitation. (PMID: 24435510) Plante G. … Manjunath P. (Mol. Hum. Reprod. 2014) 3 64
  5. Recombinant expression and affinity purification of a novel epididymal human sperm-binding protein, BSPH1. (PMID: 19091820) Lefebvre J. … Manjunath P. (Mol. Hum. Reprod. 2009) 3 64

Products for BSPH1 Gene

Sources for BSPH1 Gene

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