Aliases for BSN Gene
External Ids for BSN Gene
Previous HGNC Symbols for BSN Gene
Previous GeneCards Identifiers for BSN Gene
Neurotransmitters are released from a specific site in the axon terminal called the active zone, which is composed of synaptic vesicles and a meshwork of cytoskeleton underlying the plasma membrane. The protein encoded by this gene is thought to be a scaffolding protein involved in organizing the presynaptic cytoskeleton. The gene is expressed primarily in neurons in the brain. A similar gene product in rodents is concentrated in the active zone of axon terminals and tightly associated with cytoskeletal structures, and is essential for regulating neurotransmitter release from a subset of synapses. [provided by RefSeq, Jul 2008]
GeneCards Summary for BSN Gene
BSN (Bassoon Presynaptic Cytomatrix Protein) is a Protein Coding gene. Diseases associated with BSN include Multiple System Atrophy and Chronic Ulcer Of Skin. Among its related pathways are Neuroscience. An important paralog of this gene is PCLO.
UniProtKB/Swiss-Prot for BSN Gene
Is thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act through binding to ERC2/CAST1. Essential in regulated neurotransmitter release from a subset of brain glutamatergic synapses. Involved in the formation of the retinal photoreceptor ribbon synapses (By similarity).