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BSN Gene

protein-coding   GIFtS: 52
GCID: GC03P049591

Bassoon Presynaptic Cytomatrix Protein

(Previous name: bassoon (presynaptic cytomatrix protein))
(Previous symbol: ZNF231)
  Search for BSN
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Bassoon Presynaptic Cytomatrix Protein1 2     Neuronal Double Zinc Finger Protein1 2
ZNF2311 2 3 5     Protein Bassoon2
Zinc Finger Protein 2311 2 3     KIAA04343
Bassoon (Presynaptic Cytomatrix Protein)1 2     

External Ids:    HGNC: 11171   Entrez Gene: 89272   Ensembl: ENSG000001640617   OMIM: 6040205   UniProtKB: Q9UPA53   

Export aliases for BSN gene to outside databases

Previous GC identifers: GC03P046613 GC03M048695 GC03P049447 GC03P049550 GC03P049566


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BSN Gene:
Neurotransmitters are released from a specific site in the axon terminal called the active zone, which is composed
of synaptic vesicles and a meshwork of cytoskeleton underlying the plasma membrane. The protein encoded by this
gene is thought to be a scaffolding protein involved in organizing the presynaptic cytoskeleton. The gene is
expressed primarily in neurons in the brain. A similar gene product in rodents is concentrated in the active zone
of axon terminals and tightly associated with cytoskeletal structures, and is essential for regulating
neurotransmitter release from a subset of synapses. (provided by RefSeq, Jul 2008)

GeneCards Summary for BSN Gene:
BSN (bassoon presynaptic cytomatrix protein) is a protein-coding gene. An important paralog of this gene is PCLO.

UniProtKB/Swiss-Prot: BSN_HUMAN, Q9UPA5
Function: Is thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ)
which regulates neurotransmitter release. Seems to act through binding to ERC2/CAST1. Essential in regulated
neurotransmitter release from a subset of brain glutamatergic synapses. Involved in the formation of the retinal
photoreceptor ribbon synapses (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BSN gene promoter:
         NRSF form 1   Olf-1   NRSF form 2   CBF-C   CBF-A   CBF-B   c-Myb   CP1C   CP1A   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBSN promoter sequence
   Search Chromatin IP Primers for BSN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BSN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

BSN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BSN gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P049591:  view genomic region     (about GC identifiers)

Start:
49,591,922 bp from pter      End:
49,708,982 bp from pter
Size:
117,061 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BSN_HUMAN, Q9UPA5 (See protein sequence)
Recommended Name: Protein bassoon  
Size: 3926 amino acids; 416469 Da
Subunit: Interacts with ERC2/CAST1, RIMS1 and UNC13A. Part of a complex consisting of ERC2, RIMS1 and BSN (By
similarity)
Secondary accessions: O43161 Q7LGH3

Explore the universe of human proteins at neXtProt for BSN: NX_Q9UPA5

Explore proteomics data for BSN at MOPED

Post-translational modifications: 

  • Myristoylated. The N-terminal myristoylation is not sufficient for presynaptic localization (By similarity)1
  • Glycosylation2 at Thr1343, Thr1384, Thr2314, Thr2691, Thr2936
  • Modification sites at PhosphoSitePlus

  • See BSN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003449.2  
    ENSEMBL proteins: 
     ENSP00000296452  

    BSN Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for BSN

     
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    Novus Biologicals BSN Antibodies
    Abcam antibodies for BSN
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    LSBio Antibodies in human, mouse, rat for BSN

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    Cloud-Clone Corp. ELISAs for BSN
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    Search eBioscience for ELISAs for BSN 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR008899 Znf_piccolo
     IPR013083 Znf_RING/FYVE/PHD
     IPR011011 Znf_FYVE_PHD

    Graphical View of Domain Structure for InterPro Entry Q9UPA5

    ProtoNet protein and cluster: Q9UPA5


    Find genes that share domains with BSN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BSN_HUMAN, Q9UPA5
    Function: Is thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ)
    which regulates neurotransmitter release. Seems to act through binding to ERC2/CAST1. Essential in regulated
    neurotransmitter release from a subset of brain glutamatergic synapses. Involved in the formation of the retinal
    photoreceptor ribbon synapses (By similarity)

         Genatlas biochemistry entry for BSN:
    Bassoon,presynaptic cytomatrix protein,overexpressed in cerebella of patients with multiple system atrophy (MSA)
    potential transcriptional regulator

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with BSN           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Bsn):
     behavior/neurological  hearing/vestibular/ear  mortality/aging  muscle  nervous system 
     vision/eye 

    Find genes that share phenotypes with BSN           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BSN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BSN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BSN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BSN

    miRNA
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    miRTarBase miRNAs that target BSN:
    hsa-mir-375 (MIRT019679), hsa-mir-18a-3p (MIRT040863), hsa-mir-335-5p (MIRT016702)

    Block miRNA regulation of human, mouse, rat BSN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BSN (see all 164):
    hsa-miR-576-3p hsa-miR-1321 hsa-miR-517a hsa-miR-1224-3p hsa-miR-605 hsa-miR-3074-3p hsa-miR-3653 hsa-miR-342-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat BSN

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: BSN (NM_057176)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BSN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BSN_HUMAN, Q9UPA5: Cytoplasm (By similarity). Cell junction, synapse, synaptosome (By similarity). Cytoplasm,
    cytoskeleton. Note=Localized to the active zone of presynaptic density (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus4
    cytosol3
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS9806829
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--
    GO:0015630microtubule cytoskeleton ----
    GO:0030054cell junction IEA--

    Find genes that share ontologies with BSN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BSN About    
    See pathways by source

    SuperPathContained pathways About
    1Neuroscience
    Neuroscience


    Find genes that share SuperPaths with BSN           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for BSN
        Neuroscience


        Pathway & Disease-focused RT2 Profiler PCR Array including BSN: 
              Cardiotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BSN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for BSN (Q9UPA53 ENSP000002964524) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERC2O150833, ENSP000002882214I2D: score=2 STRING: ENSP00000288221
    GRIN1Q055863, ENSP000003606164I2D: score=2 STRING: ENSP00000360616
    ABI1Q8IZP03, ENSP000003653124I2D: score=1 STRING: ENSP00000365312
    HOMER1Q86YM73, ENSP000003343824I2D: score=1 STRING: ENSP00000334382
    RAB3AP203363, ENSP000002222564I2D: score=1 STRING: ENSP00000222256
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007268synaptic transmission TAS10329005

    Find genes that share ontologies with BSN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BSN



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BSN gene: 
    NM_003458.3  

    Unigene Cluster for BSN:

    Bassoon presynaptic cytomatrix protein
    Hs.194684  [show with all ESTs]
    Unigene Representative Sequence: AF052224
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296452(uc003cxe.4) ENST00000467456
    miRNA
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    Block miRNA regulation of human, mouse, rat BSN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BSN (see all 164):
    hsa-miR-576-3p hsa-miR-1321 hsa-miR-517a hsa-miR-1224-3p hsa-miR-605 hsa-miR-3074-3p hsa-miR-3653 hsa-miR-342-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat BSN
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BSN (NM_057176)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BSN
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat BSN
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for BSN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BSN
      QuantiTect SYBR Green Assays in human, mouse, rat BSN
      QuantiFast Probe-based Assays in human, mouse, rat BSN

    Additional mRNA sequence: 

    AB007894.1 AF052224.1 

    5 DOTS entries:

    DT.411943  DT.206144  DT.100037396  DT.91743461  DT.91947864 

    Selected AceView cDNA sequences (see all 99):

    BM914944 AA349490 BE700145 BM564812 BM713772 AF052224 AB007894 AA442888 
    BF513520 AA349294 Z45025 AL045982 NM_003458 F03960 BU787692 BU070626 
    BX105057 AA349556 BM720829 BX478545 AW152535 BE221358 BX478321 BG818094 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BSN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTTGTGAA
    BSN Expression
    About this image


    BSN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Eye (Sensory Organs)
             Retina
    BSN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BSN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.194684

    UniProtKB/Swiss-Prot: BSN_HUMAN, Q9UPA5
    Tissue specificity: Exclusively expressed in brain

        Pathway & Disease-focused RT2 Profiler PCR Array including BSN: 
              Cardiotoxicity in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BSN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BSN gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bsn1 , 5 bassoon1, 5 86.4(n)1
    88.97(a)1
      9 (59.07 cM)5
    122171  NM_007567.21  NP_031593.21 
     1080960225 
    chicken
    (Gallus gallus)
    Aves BSN1 bassoon (presynaptic cytomatrix protein) 66.53(n)
    63.35(a)
      430723  XM_004944444.1  XP_004944501.1 
    lizard
    (Anolis carolinensis)
    Reptilia BSN6
    bassoon presynaptic cytomatrix protein
    60(a)
    1 ↔ 1
    2(149274869-149553385)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia bsn1 bassoon presynaptic cytomatrix protein 60.05(n)
    60.17(a)
      100493877  XM_002936484.2  XP_002936530.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000040631 protein bassoon-like 54.26(n)
    50.57(a)
      100004063  XM_001920753.4  XP_001920788.3 
    worm
    (Caenorhabditis elegans)
    Secernentea F45E4.36
    Protein F45E4.3, isoform a
    21(a)
    1 → many
    IV(7619630-7628234) WBGene00018468


    ENSEMBL Gene Tree for BSN (if available)
    TreeFam Gene Tree for BSN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BSN gene
    PCLO2  

    Find genes that share paralogs with BSN           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BSN (see all 2122)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1467717771,2
    --49593848(+) TACTTC/TATCTG 1 -- int10--------
    rs1874681621,2
    --49593971(+) CTGAGC/TCTGTG 1 -- int10--------
    rs622612491,2
    C,F--49594060(+) GGAGGT/CGGGAT 1 -- int13Minor allele frequency- C:0.18NA WA 240
    rs1905788141,2
    --49594084(+) TGATAG/TTCATT 1 -- int10--------
    rs1490122871,2
    --49594351(+) CCTCAC/TAGAGG 1 -- int10--------
    rs768958361,2
    C,F--49594360(+) GGTGGG/TTAGAA 1 -- int11Minor allele frequency- T:0.11EA 120
    rs1437984151,2
    C--49594660(+) ATTATA/GTAATC 1 -- int10--------
    rs1827539791,2
    --49594726(+) CCACTC/TTCCAA 1 -- int10--------
    rs1481486581,2
    --49594739(+) TGTGTA/GCCCTG 1 -- int10--------
    rs729360091,2
    C,F--49594740(+) GTGTGC/TCCTGG 1 -- int13Minor allele frequency- T:0.10WA CSA 122

    HapMap Linkage Disequilibrium report for BSN (49591922 - 49708982 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for BSN:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv237379CNV Insertion16902084
    esv1436359CNV Insertion17803354
    nsv508217CNV Loss20534489
    nsv834687CNV Loss17160897
    nsv3812CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BSN
    DNA2.0 Custom Variant and Variant Library Synthesis for BSN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604020    OMIM disorders: --


    Find genes that share disorders with BSN           About GenesLikeMe

    Genetic Association Database (GAD): BSN
    Human Genome Epidemiology (HuGE) Navigator: BSN (9 documents)

    Export disorders for BSN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BSN gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with BSN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and mapping of ZNF231, a novel brain-specific gene encoding neuronal double zinc finger protein whose expression is enhanced in a neurodegenerative disorder, multiple system atrophy. (PubMed id 9806829)1, 2, 3, 9 Hashida H....Sakaki Y. (Genomics 1998)
    2. The presynaptic cytomatrix protein Bassoon: sequence and chromosomal localization of the human BSN gene. (PubMed id 10329005)1, 2, 3, 9 Winter C.... Gundelfinger E.D. (Genomics 1999)
    3. Variants at the 3p21 locus influence susceptibility and phenotype both in adults and early-onset patients with inflammatory bowel disease. (PubMed id 20024904)1, 4 Latiano A....Annese V. (Inflamm. Bowel Dis. 2010)
    4. Association analysis of 3p21 with Crohn's disease in a New Zealand population. (PubMed id 20307617)1, 4 Morgan A.R....Ferguson L.R. (Hum. Immunol. 2010)
    5. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)1, 4 So H.C....Sham P.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    6. Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study. (PubMed id 20846217)1, 4 Lee J.J....Hirschhorn J. (Ann. Hum. Genet. 2010)
    7. Effect of BSN-MST1 locus on inflammatory bowel disease and multiple sclerosis susceptibility. (PubMed id 19657358)1, 4 MA!rquez A....Urcelay E. (Genes Immun. 2009)
    8. Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. (PubMed id 19915572)1, 4  ....Strachan D.P. (Nat. Genet. 2009)
    9. Genetic risk profiling and prediction of disease course in Crohn's disease patients. (PubMed id 19422935)1, 4 Henckaerts L....Vermeire S. (Clin. Gastroenterol. Hepatol. 2009)
    10. Genetic utility of broadly defined bipolar schizoaffective disorder as a diagnostic concept. (PubMed id 19567891)1, 4 Hamshere M.L....Craddock N. (Br J Psychiatry 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8927 HGNC: 1117 AceView: BSN Ensembl:ENSG00000164061 euGenes: HUgn8927
    ECgene: BSN H-InvDB: BSN

    (According to HUGE)
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    HUGE: KIAA0434

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BSN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BSN gene:
    Search GeneIP for patents involving BSN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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