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Aliases for BSG Gene

Aliases for BSG Gene

  • Basigin (Ok Blood Group) 2 3 5
  • Tumor Cell-Derived Collagenase Stimulatory Factor 3 4
  • Extracellular Matrix Metalloproteinase Inducer 3 4
  • Leukocyte Activation Antigen M6 3 4
  • Collagenase Stimulatory Factor 3 4
  • OK Blood Group Antigen 3 4
  • EMMPRIN 3 4
  • TCSF 3 4
  • 5F7 3 4
  • Ok Blood Group 2
  • CD147 Antigen 4
  • Basigin 2
  • CD147 3
  • OK 3

External Ids for BSG Gene

Previous HGNC Symbols for BSG Gene

  • OK

Previous GeneCards Identifiers for BSG Gene

  • GC19P000624
  • GC19P000511
  • GC19P000523
  • GC19P000522
  • GC19P000462
  • GC19P000342

Summaries for BSG Gene

Entrez Gene Summary for BSG Gene

  • The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for BSG Gene

BSG (Basigin (Ok Blood Group)) is a Protein Coding gene. Diseases associated with BSG include Brain Stem Cancer and Laryngeal Benign Neoplasm. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and ECM-receptor interaction. GO annotations related to this gene include mannose binding. An important paralog of this gene is NPTN.

UniProtKB/Swiss-Prot for BSG Gene

  • Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.

Gene Wiki entry for BSG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BSG Gene

Genomics for BSG Gene

Regulatory Elements for BSG Gene

Enhancers for BSG Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BSG on UCSC Golden Path with GeneCards custom track

Promoters for BSG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BSG on UCSC Golden Path with GeneCards custom track

Genomic Location for BSG Gene

Chromosome:
19
Start:
571,277 bp from pter
End:
583,493 bp from pter
Size:
12,217 bases
Orientation:
Plus strand

Genomic View for BSG Gene

Genes around BSG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BSG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BSG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BSG Gene

Proteins for BSG Gene

  • Protein details for BSG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35613-BASI_HUMAN
    Recommended name:
    Basigin
    Protein Accession:
    P35613
    Secondary Accessions:
    • A6NJW1
    • D3YLG5
    • Q7Z796
    • Q8IZL7

    Protein attributes for BSG Gene

    Size:
    385 amino acids
    Molecular mass:
    42200 Da
    Quaternary structure:
    • Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms heterooligomers of isoform 2 and isoform 3. Forms a complex with MMP1 at the tumor cell surface. Interacts with ATP1B2, MAG and L1CAM (By similarity). Interacts with AJAP1. Interacts with SLC16A1, SLC16A7 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with PPIL2; regulates BSG transport to the cell membrane.

    Three dimensional structures from OCA and Proteopedia for BSG Gene

    Alternative splice isoforms for BSG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BSG Gene

Proteomics data for BSG Gene at MOPED

Post-translational modifications for BSG Gene

  • N-glycosylated.
  • Ubiquitination at Lys 173, Lys 179, Lys 227, Lys 243, Lys 257, and Lys 307
  • Glycosylation at Thr 145, Asn 160, Asn 268, and Asn 302
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BSG Gene

Domains & Families for BSG Gene

Suggested Antigen Peptide Sequences for BSG Gene

Graphical View of Domain Structure for InterPro Entry

P35613

UniProtKB/Swiss-Prot:

BASI_HUMAN :
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with BSG: view

Function for BSG Gene

Molecular function for BSG Gene

GENATLAS Biochemistry:
basigin,widely expressed,involved in cell recognition,broadly expressed on hematopoietic cells stimulating nearly fibroblasts to synthesize matrix metalloproteinases,member of the Ig superfamily
UniProtKB/Swiss-Prot Function:
Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.
UniProtKB/Swiss-Prot Induction:
Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with malignant potential of the tumor.
genes like me logo Genes that share phenotypes with BSG: view

Animal Models for BSG Gene

MGI Knock Outs for BSG:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BSG Gene

Localization for BSG Gene

Subcellular locations from UniProtKB/Swiss-Prot for BSG Gene

Cell membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In spermatozoa, localized on the principal piece of caput and in the middle piece during transit in the corpus and cauda epididymides (By similarity). {ECO:0000250 UniProtKB:P18572, ECO:0000269 PubMed:17081065}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BSG Gene COMPARTMENTS Subcellular localization image for BSG gene
Compartment Confidence
extracellular 5
golgi apparatus 5
mitochondrion 5
plasma membrane 5
lysosome 3
vacuole 3
endoplasmic reticulum 2
endosome 2
cytoskeleton 1
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BSG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002080 acrosomal membrane IEA --
GO:0005739 mitochondrion IDA 20833797
GO:0005887 integral component of plasma membrane ISS --
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BSG: view

Pathways & Interactions for BSG Gene

genes like me logo Genes that share pathways with BSG: view

Pathways by source for BSG Gene

Gene Ontology (GO) - Biological Process for BSG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway TAS 9767135
GO:0007566 embryo implantation IEA --
GO:0007596 blood coagulation TAS --
GO:0015718 monocarboxylic acid transport TAS --
GO:0022617 extracellular matrix disassembly TAS --
genes like me logo Genes that share ontologies with BSG: view

No data available for SIGNOR curated interactions for BSG Gene

Drugs & Compounds for BSG Gene

(17) Drugs for BSG Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(10) Additional Compounds for BSG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BSG: view

Transcripts for BSG Gene

Unigene Clusters for BSG Gene

Basigin (Ok blood group):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BSG Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b ·
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: -
SP5: - - - - - - - - -
SP6: - - - - - -
SP7: - - - - - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - -
SP10: - - - -
SP11: - - - - - - - - - -
SP12: - -
SP13: -

ExUns: 11c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for BSG Gene

GeneLoc Exon Structure for
BSG
ECgene alternative splicing isoforms for
BSG

Expression for BSG Gene

mRNA expression in normal human tissues for BSG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BSG Gene

This gene is overexpressed in Heart - Left Ventricle (x4.2).

Protein differential expression in normal tissues from HIPED for BSG Gene

This gene is overexpressed in Nasal epithelium (13.1) and Retina (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BSG Gene



SOURCE GeneReport for Unigene cluster for BSG Gene Hs.501293

mRNA Expression by UniProt/SwissProt for BSG Gene

P35613-BASI_HUMAN
Tissue specificity: Present only in vascular endothelium in non-neoplastic regions of the brain, whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas.
genes like me logo Genes that share expression patterns with BSG: view

Protein tissue co-expression partners for BSG Gene

Orthologs for BSG Gene

This gene was present in the common ancestor of animals.

Orthologs for BSG Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Bsg 35
  • 72.47 (n)
  • 65.71 (a)
Bsg 16
Bsg 36
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BSG 35
  • 96.24 (n)
  • 93.85 (a)
BSG 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bsg 35
  • 74.72 (n)
  • 65.71 (a)
cow
(Bos Taurus)
Mammalia BSG 36
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BSG 36
  • 57 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BSG 36
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BSG 36
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves BSG 35
  • 63.49 (n)
  • 55.29 (a)
BSG 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BSG 36
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii bsg 35
  • 57.43 (n)
  • 47.49 (a)
bsg 36
  • 43 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2134 35
fruit fly
(Drosophila melanogaster)
Insecta Bsg 36
  • 10 (a)
OneToMany
Species with no ortholog for BSG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BSG Gene

ENSEMBL:
Gene Tree for BSG (if available)
TreeFam:
Gene Tree for BSG (if available)

Paralogs for BSG Gene

Paralogs for BSG Gene

(3) SIMAP similar genes for BSG Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with BSG: view

Variants for BSG Gene

Sequence variations from dbSNP and Humsavar for BSG Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1803203 - 581,328(+) GAACG(G/T)CTCCG reference, missense
VAR_013574 -
rs7259828 -- 574,301(+) gtaat(C/T)ccagc intron-variant
rs7260603 -- 577,246(+) AATCC(A/G)CCTCT intron-variant
rs12977323 -- 580,953(+) CGGAC(C/T)CAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BSG Gene

Variant ID Type Subtype PubMed ID
nsv428360 CNV Gain 18775914
dgv3498n71 CNV Loss 21882294
nsv910102 CNV Loss 21882294
nsv910109 CNV Loss 21882294
nsv470101 CNV Loss 18288195
nsv910119 CNV Gain 21882294
dgv3508n71 CNV Loss 21882294
dgv3510n71 CNV Loss 21882294
dgv3511n71 CNV Loss 21882294
nsv910137 CNV Loss 21882294
dgv3512n71 CNV Loss 21882294
dgv3513n71 CNV Loss 21882294
dgv3514n71 CNV Gain 21882294
dgv3515n71 CNV Loss 21882294
dgv3516n71 CNV Loss 21882294
nsv910156 CNV Loss 21882294
dgv3517n71 CNV Loss 21882294
dgv3518n71 CNV Loss 21882294
dgv3519n71 CNV Gain+Loss 21882294
nsv910170 CNV Loss 21882294
nsv910172 CNV Gain+Loss 21882294
nsv910173 CNV Loss 21882294
dgv3520n71 CNV Gain 21882294
nsv910175 CNV Loss 21882294
dgv3521n71 CNV Loss 21882294
nsv910177 CNV Loss 21882294
dgv3522n71 CNV Loss 21882294
dgv3523n71 CNV Gain 21882294
nsv910183 CNV Gain 21882294
nsv910185 CNV Loss 21882294
dgv3524n71 CNV Loss 21882294
nsv910187 CNV Loss 21882294
nsv910188 CNV Gain 21882294
dgv3525n71 CNV Loss 21882294
nsv910193 CNV Loss 21882294
dgv3526n71 CNV Loss 21882294
nsv910195 CNV Loss 21882294
dgv3527n71 CNV Loss 21882294
nsv910197 CNV Gain 21882294
esv2717744 CNV Deletion 23290073
dgv3528n71 CNV Loss 21882294
nsv910211 CNV Loss 21882294
dgv3529n71 CNV Loss 21882294

Variation tolerance for BSG Gene

Residual Variation Intolerance Score: 25.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.65; 31.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BSG Gene

Human Gene Mutation Database (HGMD)
BSG
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group System

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BSG Gene

Disorders for BSG Gene

MalaCards: The human disease database

(15) MalaCards diseases for BSG Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
brain stem cancer
  • malignant neoplasm of brain stem
laryngeal benign neoplasm
  • laryngeal tumor
brain stem glioma
  • brainstem neuroglial tumor
accommodative esotropia
  • esotropia with accommodative compensation
spinal cord astrocytoma
  • astrocytoma of spinal cord
- elite association - COSMIC cancer census association via MalaCards
Search BSG in MalaCards View complete list of genes associated with diseases

Relevant External Links for BSG

Genetic Association Database (GAD)
BSG
Human Genome Epidemiology (HuGE) Navigator
BSG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BSG
genes like me logo Genes that share disorders with BSG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BSG Gene

Publications for BSG Gene

  1. The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily. (PMID: 7812975) Biswas C. … Nabeshima K. (Cancer Res. 1995) 2 3 4 23 67
  2. EMMPRIN and its ligand cyclophilin A regulate MT1-MMP, MMP-9 and M-CSF during foam cell formation. (PMID: 19758589) Seizer P. … May A.E. (Atherosclerosis 2010) 3 23
  3. Expression of EMMPRIN (CD147) on circulating platelets in vivo. (PMID: 19995409) Pennings G.J. … Kritharides L. (J. Thromb. Haemost. 2010) 3 23
  4. A Competitive ELISA for quantifying serum CD147: reduction of soluble CD147 levels in cancer patient sera. (PMID: 20199151) Moonsom S. … Kasinrerk W. (Hybridoma (Larchmt) 2010) 3 23
  5. Direct activation of emmprin and associated pathogenesis by an oncogenic herpesvirus. (PMID: 20406987) Qin Z. … Parsons C. (Cancer Res. 2010) 3 23

Products for BSG Gene

Sources for BSG Gene

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