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Aliases for BSG Gene

Aliases for BSG Gene

  • Basigin (Ok Blood Group) 2 3
  • Tumor Cell-Derived Collagenase Stimulatory Factor 3 4
  • Extracellular Matrix Metalloproteinase Inducer 3 4
  • Leukocyte Activation Antigen M6 3 4
  • Collagenase Stimulatory Factor 3 4
  • OK Blood Group Antigen 3 4
  • CD147 Antigen 3 4
  • Basigin 2 3
  • EMMPRIN 3 4
  • TCSF 3 4
  • 5F7 3 4
  • Ok Blood Group 2
  • CD147 3
  • M6 3
  • OK 3

External Ids for BSG Gene

Previous HGNC Symbols for BSG Gene

  • OK

Previous GeneCards Identifiers for BSG Gene

  • GC19P000624
  • GC19P000511
  • GC19P000523
  • GC19P000522
  • GC19P000462
  • GC19P000342

Summaries for BSG Gene

Entrez Gene Summary for BSG Gene

  • The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for BSG Gene

BSG (Basigin (Ok Blood Group)) is a Protein Coding gene. Diseases associated with BSG include spinal cord astrocytoma and brain stem glioma. Among its related pathways are Hemostasis and Degradation of the extracellular matrix. GO annotations related to this gene include mannose binding. An important paralog of this gene is NPTN.

UniProtKB/Swiss-Prot for BSG Gene

  • Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.

Gene Wiki entry for BSG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BSG Gene

Genomics for BSG Gene

Regulatory Elements for BSG Gene

Genomic Location for BSG Gene

Start:
571,277 bp from pter
End:
583,493 bp from pter
Size:
12,217 bases
Orientation:
Plus strand

Genomic View for BSG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BSG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BSG Gene

Proteins for BSG Gene

  • Protein details for BSG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35613-BASI_HUMAN
    Recommended name:
    Basigin
    Protein Accession:
    P35613
    Secondary Accessions:
    • A6NJW1
    • D3YLG5
    • Q7Z796
    • Q8IZL7

    Protein attributes for BSG Gene

    Size:
    385 amino acids
    Molecular mass:
    42200 Da
    Quaternary structure:
    • Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms heterooligomers of isoform 2 and isoform 3. Forms a complex with MMP1 at the tumor cell surface. Interacts with ATP1B2, MAG and L1CAM (By similarity). Interacts with AJAP1. Interacts with SLC16A1, SLC16A7 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with PPIL2; regulates BSG transport to the cell membrane.

    Three dimensional structures from OCA and Proteopedia for BSG Gene

    Alternative splice isoforms for BSG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BSG Gene

Proteomics data for BSG Gene at MOPED

Post-translational modifications for BSG Gene

  • N-glycosylated.
  • Ubiquitination at Lys173, Lys179, Lys227, Lys243, Lys257, Lys264, and Lys307
  • Glycosylation at Thr145, Asn160, Asn268, and Asn302
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BSG Gene

Domains for BSG Gene

Gene Families for BSG Gene

HGNC:
  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • ISET :Immunoglobulin superfamily / I-set domain containing
  • bloodgroup :Blood group antigens

Suggested Antigen Peptide Sequences for BSG Gene

Graphical View of Domain Structure for InterPro Entry

P35613

UniProtKB/Swiss-Prot:

BASI_HUMAN :
  • P35613
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with BSG: view

Function for BSG Gene

Molecular function for BSG Gene

GENATLAS Biochemistry: basigin,widely expressed,involved in cell recognition,broadly expressed on hematopoietic cells stimulating nearly fibroblasts to synthesize matrix metalloproteinases,member of the Ig superfamily
UniProtKB/Swiss-Prot Function: Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.
UniProtKB/Swiss-Prot Induction: Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with malignant potential of the tumor

Gene Ontology (GO) - Molecular Function for BSG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15946952
GO:0005537 mannose binding IEA --
genes like me logo Genes that share ontologies with BSG: view
genes like me logo Genes that share phenotypes with BSG: view

Animal Models for BSG Gene

MGI Knock Outs for BSG:

miRNA for BSG Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BSG Gene

Localization for BSG Gene

Subcellular locations from UniProtKB/Swiss-Prot for BSG Gene

Cell membrane; Single-pass type I membrane protein. Melanosome. Note=Colocalizes with SLC16A1 and SLC16A8. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000250 UniProtKB:P18572, ECO:0000269 PubMed:17081065}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BSG Gene COMPARTMENTS Subcellular localization image for BSG gene
Compartment Confidence
plasma membrane 5
golgi apparatus 4
endoplasmic reticulum 2
extracellular 2
mitochondrion 2
cytoskeleton 1
lysosome 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BSG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0002080 acrosomal membrane IEA --
GO:0005739 mitochondrion IDA 20833797
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane ISS --
genes like me logo Genes that share ontologies with BSG: view

Pathways for BSG Gene

genes like me logo Genes that share pathways with BSG: view

Pathways by source for BSG Gene

Gene Ontology (GO) - Biological Process for BSG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006090 pyruvate metabolic process TAS --
GO:0007166 cell surface receptor signaling pathway TAS 9767135
GO:0007566 embryo implantation IEA --
GO:0007596 blood coagulation TAS --
GO:0022617 extracellular matrix disassembly TAS --
genes like me logo Genes that share ontologies with BSG: view

Compounds for BSG Gene

(27) Novoseek inferred chemical compound relationships for BSG Gene

Compound -log(P) Hits PubMed IDs
prinomastat 73.3 1
gw9662 45.7 1
vegf 39 42
lactate 35.1 23
sb 203580 29 1
genes like me logo Genes that share compounds with BSG: view

Transcripts for BSG Gene

Unigene Clusters for BSG Gene

Basigin (Ok blood group):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BSG Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b ·
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: -
SP5: - - - - - - - - -
SP6: - - - - - -
SP7: - - - - - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - -
SP10: - - - -
SP11: - - - - - - - - - -
SP12: - -
SP13: -

ExUns: 11c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for BSG Gene

GeneLoc Exon Structure for
BSG
ECgene alternative splicing isoforms for
BSG

Expression for BSG Gene

mRNA expression in normal human tissues for BSG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BSG Gene

This gene is overexpressed in Heart - Left Ventricle (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BSG Gene

SOURCE GeneReport for Unigene cluster for BSG Gene Hs.501293

mRNA Expression by UniProt/SwissProt for BSG Gene

P35613-BASI_HUMAN
Tissue specificity: Present only in vascular endothelium in non-neoplastic regions of the brain, whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas
genes like me logo Genes that share expressions with BSG: view

Orthologs for BSG Gene

This gene was present in the common ancestor of animals.

Orthologs for BSG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BSG 35
  • 96.24 (n)
  • 93.85 (a)
BSG 36
  • 86 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BSG 36
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BSG 36
  • 57 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bsg 35
  • 72.47 (n)
  • 65.71 (a)
Bsg 16
Bsg 36
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BSG 36
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BSG 36
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bsg 35
  • 74.72 (n)
  • 65.71 (a)
chicken
(Gallus gallus)
Aves BSG 35
  • 63.49 (n)
  • 55.29 (a)
BSG 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BSG 36
  • 64 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2134 35
zebrafish
(Danio rerio)
Actinopterygii bsg 35
  • 57.43 (n)
  • 47.49 (a)
bsg 36
  • 43 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Bsg 36
  • 10 (a)
OneToMany
Species with no ortholog for BSG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BSG Gene

ENSEMBL:
Gene Tree for BSG (if available)
TreeFam:
Gene Tree for BSG (if available)

Paralogs for BSG Gene

Paralogs for BSG Gene

Selected SIMAP similar genes for BSG Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with BSG: view

Variants for BSG Gene

Sequence variations from dbSNP and Humsavar for BSG Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs4682 -- 580,665(+) AAGGC(C/T)GTGAA synonymous-codon, reference
rs6757 -- 583,418(+) CTCTC(C/T)ATAGC utr-variant-3-prime
rs6758 -- 583,460(+) CCACC(A/G)CCACA utr-variant-3-prime
rs8259 -- 582,927(-) AAAAA(A/T)CCTAA utr-variant-3-prime
rs8637 -- 582,775(+) GCTCC(A/G)CGTCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for BSG Gene

Variant ID Type Subtype PubMed ID
nsv428360 CNV Gain 18775914
dgv3498n71 CNV Loss 21882294
nsv910102 CNV Loss 21882294
nsv910109 CNV Loss 21882294
nsv470101 CNV Loss 18288195
nsv910119 CNV Gain 21882294
dgv3508n71 CNV Loss 21882294
dgv3510n71 CNV Loss 21882294
dgv3511n71 CNV Loss 21882294
nsv910137 CNV Loss 21882294
dgv3512n71 CNV Loss 21882294
dgv3513n71 CNV Loss 21882294
dgv3514n71 CNV Gain 21882294
dgv3515n71 CNV Loss 21882294
dgv3516n71 CNV Loss 21882294
nsv910156 CNV Loss 21882294
dgv3517n71 CNV Loss 21882294
dgv3518n71 CNV Loss 21882294
dgv3519n71 CNV Gain+Loss 21882294
nsv910170 CNV Loss 21882294
nsv910172 CNV Gain+Loss 21882294
nsv910173 CNV Loss 21882294
dgv3520n71 CNV Gain 21882294
nsv910175 CNV Loss 21882294
dgv3521n71 CNV Loss 21882294
nsv910177 CNV Loss 21882294
dgv3522n71 CNV Loss 21882294
dgv3523n71 CNV Gain 21882294
nsv910183 CNV Gain 21882294
nsv910185 CNV Loss 21882294
dgv3524n71 CNV Loss 21882294
nsv910187 CNV Loss 21882294
nsv910188 CNV Gain 21882294
dgv3525n71 CNV Loss 21882294
nsv910193 CNV Loss 21882294
dgv3526n71 CNV Loss 21882294
nsv910195 CNV Loss 21882294
dgv3527n71 CNV Loss 21882294
nsv910197 CNV Gain 21882294
esv2717744 CNV Deletion 23290073
dgv3528n71 CNV Loss 21882294
nsv910211 CNV Loss 21882294
dgv3529n71 CNV Loss 21882294

Relevant External Links for BSG Gene

HapMap Linkage Disequilibrium report
BSG
Human Gene Mutation Database (HGMD)
BSG
Locus Specific Mutation Databases (LSDB)
BSG
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BSG Gene

Disorders for BSG Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for BSG Gene including...

Search for BSG Gene in MalaCards »

(1) OMIM Diseases for BSG Gene (109480)

(2) University of Copenhagen DISEASES for BSG Gene

(71) Novoseek inferred disease relationships for BSG Gene

Disease -log(P) Hits PubMed IDs
metastasis 61.6 66
tumors 58 232
carcinoma 46.6 30
cancer 46.4 82
chronic periodontitis 44.6 3

Relevant External Links for BSG

Genetic Association Database (GAD)
BSG
Human Genome Epidemiology (HuGE) Navigator
BSG
genes like me logo Genes that share disorders with BSG: view

No data available for UniProtKB/Swiss-Prot for BSG Gene

Publications for BSG Gene

  1. The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily. (PMID: 7812975) Biswas C. … Nabeshima K. (Cancer Res. 1995) 2 3 4 23
  2. Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin, and chicken HT7 molecule. (PMID: 1634773) Kasinrerk W. … Stockinger H. (J. Immunol. 1992) 3 4 23
  3. Partial sequencing and characterization of the tumor cell-derived collagenase stimulatory factor. (PMID: 1846736) Nabeshima K. … Biswas C. (Arch. Biochem. Biophys. 1991) 3 4 23
  4. Characterization of the gene for human EMMPRIN, a tumor cell surface inducer of matrix metalloproteinases. (PMID: 9767135) Guo H. … Gordon M.K. (Gene 1998) 3 4 23
  5. Basigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion. (PMID: 12792908) Muramatsu T. … Miyauchi T. (Histol. Histopathol. 2003) 3 4 23

Products for BSG Gene

  • Addgene plasmids for BSG

Sources for BSG Gene

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