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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BSG Gene

protein-coding GIFtS: 67
GCID: GC19P000571

basigin (Ok blood group)

(Previous name: basigin (OK blood group) )
(Previous symbol: OK)

Explore 118 diseases affiliated with
BSG via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Basigin (Ok Blood Group)¹ ²		Tumor Cell-Derived Collagenase Stimulatory Factor² ³
EMMPRIN¹ ² ³		5F7² ³
CD147¹ ²		TCSF² ³
OK¹ ²		CD147 Antigen² ³
Collagenase Stimulatory Factor² ³		OK Blood Group Antigen² ³
Extracellular Matrix Metalloproteinase Inducer² ³		M6²
Leukocyte Activation Antigen M6² ³		Basigin¹

External Ids:	HGNC: 1116¹	Entrez Gene: 682²	Ensembl: ENSG00000172270⁷	OMIM: 109480⁵	UniProtKB: P35613³

Export aliases for BSG gene to outside databases

Previous GC identifers: GC19P000624 GC19P000511 GC19P000523 GC19P000522 GC19P000462 GC19P000342

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BSG:

The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo

implantation, neural network formation, and tumor progression. The encoded protein is also a member of the

immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: BASI_HUMAN, P35613

Function: Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression.

Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters

SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a

receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes (By similarity)

Gene Wiki entry for BSG (Basigin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011255.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BSG gene promoter:
AP-1 AP-2alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): BSG promoter sequence

Search SABiosciences Chromatin IP Primers for BSG

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BSG

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3

BSG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BSG gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P000571: view genomic region (about GC identifiers)

Start:	571,297 bp from pter	End:	583,493 bp from pter
Size:	12,197 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BASI_HUMAN, P35613 (See protein sequence)

Recommended Name: Basigin precursor

Size: 385 amino acids; 42200 Da

Subunit: Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms heterooligomers of isoform 2 and

isoform 3. Forms a complex with MMP1 at the tumor cell surface. Interacts with SLC16A1 and SLC1A3; probably a BSG

dimer is associated with a monocarboxylate transporter dimer. Interacts with ATP1B2, MAG and L1CAM (By similarity).

Interacts with AJAP1

Subcellular location: Cell membrane; Single-pass type I membrane protein. Melanosome. Note=Colocalizes with SLC16A1 and

SLC16A8 (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV

5 PDB 3D structures from and Proteopedia for BSG:

3B5H (3D)

3I84 (3D)

3I85 (3D)

3QQN (3D)

3QR2 (3D)

Secondary accessions: A6NJW1 D3YLG5 Q7Z796 Q8IZL7

Alternative promoter usage, Alternative splicing: 4 isoforms: P35613-1 P35613-2 P35613-3 P35613-4 (Produced by alternative promoter usage. N-glycosylated)

Explore the universe of human proteins at neXtProt for BSG: NX_P35613

Post-translational modifications:

N-glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P35613

BSG Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001719.2 NP_940991.1 NP_940992.1 NP_940993.1

ENSEMBL proteins:

ENSP00000344707 ENSP00000333769 ENSP00000458665 ENSP00000343809 ENSP00000461494

Reactome Protein details: P35613
Human Recombinant Protein Products for BSG:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for BSG (EMMPRIN)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): BSG OriGene Protein Over-expression Lysate (see all 3): BSG OriGene Custom Protein Services for BSG
	GenScript Custom Purified and Recombinant Proteins Services for BSG
	Novus Biologicals BSG Proteins Novus Biologicals BSG Lysates
	Sino Biological Recombinant Protein for BSG
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for BSG

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	TAS	--
GO:0002080	acrosomal membrane	IEA	--
GO:0005739	mitochondrion	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0016020	membrane	--	--

BSG for ontologies About GeneDecksing

BSG Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of BSG
	R&D Systems Antibodies for BSG (EMMPRIN, TRA-1-85)
	Cell Signaling Technology (CST) Antibodies for BSG
	OriGene Antibodies (see all 14): BSG OriGene Custom Antibody Services for BSG
	GenScript Custom Superior Antibodies Services for BSG
	Novus Biologicals BSG Antibodies
	Abcam antibodies for BSG
	Uscn Antibodies for BSG
	ThermoFisher Antibody for BSG

Assay Products for BSG:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for BSG (EMMPRIN) (see all)
	GenScript Custom Assay Services for BSG
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for BSG

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BSG for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR003598 Ig_sub2

IPR007110 Ig-like_dom

IPR003599 Ig_sub

IPR013098 Ig_I-set

IPR013783 Ig-like_fold

Graphical View of Domain Structure for InterPro Entry P35613

ProtoNet protein and cluster: P35613

2 Blocks protein families:

IPB003598 Immunoglobulin C-2 type

IPB003599 Immunoglobulin subtype

UniProtKB/Swiss-Prot: BASI_HUMAN, P35613

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: BASI_HUMAN, P35613

Function: Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression.

Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters

SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a

receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes (By similarity)

Induction: Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with

malignant potential of the tumor

Genatlas biochemistry entry for BSG:

basigin,widely expressed,involved in cell recognition,broadly expressed on hematopoietic cells stimulating nearly

fibroblasts to synthesize matrix metalloproteinases,member of the Ig superfamily

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0005537	mannose binding	IEA	--

BSG for ontologies About GeneDecksing

Phenotypes:
6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Bsg):

growth/size	immune system	liver/biliary system	mortality/aging	reproductive system
respiratory system

BSG for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Bsg^tm1Tmu for BSG

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for BSG

miRNA Products:		OriGene 3'-UTR Clone (see all 3): BSG Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BSG
		1 QIAGEN miScript miRNA Assays for microRNA that regulate BSG:
		hsa-miR-1324
		SwitchGear 3'UTR luciferase reporter plasmid: BSG 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BSG (see all 7) OriGene shRNA RFP: BSG OriGene siRNA: BSG
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BSG
		Sirion Biotech Custom design and validation of potent shRNA sequences against BSG

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for BSG
			Sirion Biotech Customized adenovirus for overexpression of BSG Sirion Biotech Customized adenovirus for potent knockdown of BSG

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BSG (see all 8) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BSG (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): BSG (NM_198589)
		Sino Biological Human cDNA Clone for BSG
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for BSG
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BSG

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for BSG
		Search LifeMap BioReagents cell lines for BSG
		Sirion Biotech Customized stable knockdown cell line services for BSG Sirion Biotech Customized inducible knockdown cell line services for BSG Sirion Biotech Customized stable overexpressing cell line services for BSG Sirion Biotech Customized inducible overexpressing cell line services for BSG

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BSG

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Adhesion

Adhesion

1.00

Pyruvate metabolism

Pyruvate metabolism

1.00

Basigin interactions

Basigin interactions

1.00

Metabolism

Metabolism

1.00

Matrix Metalloproteinases

Matrix Metalloproteinases

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for BSG

Adhesion

2 BioSystems Pathways for BSG

	Matrix Metalloproteinases
	Syndecan-1-mediated signaling events

5/9 Reactome Pathways for BSG (see all 9)

	Pyruvate metabolism and Citric Acid (TCA) cycle
	Hemostasis
	Pyruvate metabolism
	Integrin cell surface interactions
	Signal Transduction

BSG for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for BSG

STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

5/41 Interacting proteins for BSG (P35613^{2, 3} ENSP00000333769⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 41)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PDLIM7	Q9NR12²^,³, ENSP00000348099⁴	MINT-67881 I2D: score=5 STRING: ENSP00000348099
CAV1	Q03135³, ENSP00000339191⁴	I2D: score=2 STRING: ENSP00000339191
MMP1	P03956³, ENSP00000322788⁴	I2D: score=2 STRING: ENSP00000322788
PPIA	P62937³, ENSP00000419425⁴	I2D: score=2 STRING: ENSP00000419425
RFXANK	O14593³, ENSP00000305071⁴	I2D: score=2 STRING: ENSP00000305071

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006090	pyruvate metabolic process	TAS	--
GO:0007166	cell surface receptor signaling pathway	TAS	9767135
GO:0007566	embryo implantation	IEA	--
GO:0007596	blood coagulation	TAS	--
GO:0042475	odontogenesis of dentin-containing tooth	IEA	--

BSG for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

BSG for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for BSG
10/27 Novoseek chemical compound relationships for BSG gene (see all 27) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
prinomastat	73.3	2	11726397 (1)
gw9662	45.7	1	17007354 (1)
vegf	39	53	17633444 (7), 19837976 (5), 15833850 (5), 16778084 (4) (see all 16)
lactate	35.1	28	18761711 (3), 18778892 (2), 10921872 (2), 16434551 (2) (see all 15)
sb 203580	29	1	9877171 (1)
resveratrol	23.5	20	17007354 (7), 18647594 (6), 17055343 (5), 19561311 (1)
heparan sulfate	23.2	4	17267519 (2), 14557624 (1), 17540735 (1)
pioglitazone	20.4	5	17007354 (2), 17055343 (2), 16860414 (1)
cyclosporin a	18.7	11	11353871 (3), 15946952 (2), 15671024 (1), 15732868 (1) (see all 5)
cytochalasin b	17.7	2	11402500 (1)

Search CenterWatch for drugs/clinical trials and news about BSG / BASI

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for BSG gene (4 alternative transcripts):

NM_001728.3 NM_198589.2 NM_198590.2 NM_198591.2

Unigene Cluster for BSG:

Basigin (Ok blood group)

Hs.501293 [show with all ESTs]

Unigene Representative Sequence: NM_001728

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000346916(uc002loy.3) ENST00000545507(uc021ulx.1) ENST00000333511(uc002loz.3 uc002lpa.3)

ENST00000576925 ENST00000573216 ENST00000353555 ENST00000590218 ENST00000572899

ENST00000575414 ENST00000573784 ENST00000574970 ENST00000576984 ENST00000571735(uc002lpc.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 3): BSG Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BSG
		1 QIAGEN miScript miRNA Assays for microRNA that regulate BSG:
		hsa-miR-1324
		SwitchGear 3'UTR luciferase reporter plasmid: BSG 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BSG (see all 7) OriGene shRNA RFP: BSG OriGene siRNA: BSG
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BSG
		Sirion Biotech Custom design and validation of potent shRNA sequences against BSG

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BSG (see all 8) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BSG (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): BSG (NM_198589)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for BSG
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BSG

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BSG Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat BSG
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BSG
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BSG

Additional cDNA sequence:

AB072923.1 AB085790.1 AB091680.1 AF548371.1 AK296858.1 AK297880.1 AK302231.1 AY358113.1

BC009040.2 D45131.1 GU557064.1 GU557065.1 L10240.1 L20471.1 M87879.1 X64364.1

24/63 DOTS entries (see all 63):

DT.91668770 DT.453436 DT.121413366 DT.100888619 DT.100888658 DT.100759067 DT.121413196 DT.95301640

DT.91642062 DT.100888660 DT.91804848 DT.100700252 DT.100888653 DT.95161666 DT.121413247 DT.100888564

DT.100888620 DT.102843970 DT.100888633 DT.100888612 DT.100888566 DT.97861008 DT.95161635 DT.100888568

24/1946 AceView cDNA sequences (see all 1946):

AU150275 BP337873 AU077209 BF312542 CF264973 CR591697 CB112612 BF339063

BM829049 BF345646 BP362780 AW239029 CA439356 CB152609 CA397421 CR611405

CR597284 CD370300 BQ084324 BQ676360 BU184042 BM560927 BE383363 BI753130

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for BSG (see all 13) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	·	2d	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	·	5d	·	5e	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	·	8c	·	8d	^	9	^	10	^	11a	·	11b	·
SP1:													-				-		-												-
SP2:													-		-		-		-												-
SP3:													-		-		-		-												-
SP4:																															-
SP5:					-		-		-		-		-		-		-		-												-

ExUns:	11c
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for BSG

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BSG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCGGGTGGG

About this image

BSG expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Endothelial Cells

Selective marker (cell-identifying gene)

Blood Brain Barrier, Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

human Fetal Gonadal Stromal Cell (Primary Cell)

Reproductive System

See BSG Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BSG

SOURCE GeneReport for Unigene cluster: Hs.501293

UniProtKB/Swiss-Prot: BASI_HUMAN, P35613

Tissue specificity: Present only in vascular endothelium in non-neoplastic regions of the brain, whereas it is present

in tumor cells but not in proliferating blood vessels in malignant gliomas

SABiosciences Custom PCR Arrays for BSG

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BSG Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat BSG
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BSG
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BSG

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BSG

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for BSG gene from 5/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	BSG¹	basigin (Ok blood group)	62.73(n) 54.16(a)		770363 NM_001198990.1 NP_001185919.1
lizard (Anolis carolinensis)	Reptilia	BSG⁶	--	63(a)	1 ↔ 1	GL344297.1(45012-45362)
African clawed frog (Xenopus laevis)	Amphibia	BU906264.1²	--	75.29(n)		BU906264.1
zebrafish (Danio rerio)	Actinopterygii	BI562797.1²	--	76.72(n)		BI562797.1
fruit fly (Drosophila melanogaster)	Insecta	Bsg⁶	Basigin	13(a)	1 → many	2L(8083420-8116531)

ENSEMBL Gene Tree for BSG (if available)
TreeFam Gene Tree for BSG (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for BSG gene

NPTN² EMB²

3 SIMAP similar genes for BSG using alignment to 3 protein entries: BASI_HUMAN (see all proteins):

hEMMPRIN NPTN DKFZp566H1924

BSG for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs104894669^1,2	C	pathogenic	580428(+)	`TCCCCA/GAGCCC`	7	K E	mis¹ ut5¹		0	--	--	--	--
rs28992477^1,2	C,F	--	351607(+)	`CCCTCA/CGGACT`	1	--	int¹		5		NS NA WA	96
rs12459868^1,2	C,H	--	351620(+)	`GTGAGA/GGGCCT`	1	--	int¹		0	--	--	--	--
rs28992478^1,2	C,F	--	351624(+)	`GGGGCC/G/TTAGAC`	1	--	int¹		6		NS NA WA	102
rs12974070^1,2	C,F	--	351653(+)	`CCCTCA/CGGACT`	1	--	int¹		7		NS NA WA	98
rs12461605^1,2	C,H	--	351670(+)	`GGGGCG/CTAGAC`	1	--	int¹		1		WA	2
rs137985895^1,2	C	--	569308(+)	`TTCTT-/AATCTG`	2	--	us2k¹		0	--	--	--	--
rs143275460^1,2		--	569324(+)	`TAAGTC/TTGTTT`	2	--	us2k¹		0	--	--	--	--
rs148250938^1,2		--	569357(+)	`GGCGCA/GGTGGC`	2	--	us2k¹		0	--	--	--	--
rs62132623^1,2	C	--	569500(+)	`CGGGCA/GCCTGT`	2	--	us2k¹		3		NA	6

HapMap Linkage Disequilibrium report for BSG (571297 - 583493 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for BSG
1 CNV: 30050
1 Indel: 34333
Human Gene Mutation Database (HGMD): BSG

Locus Specific Mutation Databases (LSDB): BSG
Blood Group Antigen Gene Mutation Database (BGMUT) blood group system

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BSG

DNA2.0 Custom Variant and Variant Library Synthesis for BSG

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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BSG for disorders           About GeneDecksing

OMIM gene information: 109480
OMIM disorders: 111380
20/118 diseases for BSG (see all 118):    About MalaCards

spinal cord astrocytoma anaplastic large cell lymphoma chronic venous leg ulcers age related macular degeneration

fibrous histiocytoma brain stem neoplasm squamous cell carcinoma laryngeal squamous cell carcinoma

malignant fibrous histiocytoma non-hodgkin lymphoma bladder transitional cell carcinoma congestive heart failure

anaplastic astrocytoma transitional cell carcinoma macular degeneration primary effusion lymphoma

amyotrophic lateral sclerosis gingival overgrowth ankylosing spondylitis cutaneous malignant melanoma

3 diseases from the University of Copenhagen DISEASES database for BSG:

Brain stem glioma Carcinoma Hepatocellular carcinoma

10/71 Novoseek disease relationships for BSG gene (see all 71) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis	61.6	101	11992541 (5), 19541433 (5), 18223224 (3), 16004819 (3) (see all 45)
tumors	58	444	15833850 (8), 16633062 (6), 19569245 (6), 14985463 (6) (see all 99)
carcinoma	46.6	36	14983875 (3), 19956835 (3), 19286191 (3), 19105397 (2) (see all 23)
cancer	46.4	150	20199151 (5), 11395366 (4), 19597352 (3), 20406987 (3) (see all 57)
chronic periodontitis	44.6	3	15853964 (1), 18315429 (1), 19515022 (1)
stromal tumors	43	1	15833850 (1)
laryngeal squamous cell carcinoma	42	6	16176007 (5), 18431027 (1)
atherosclerotic plaque	38.7	22	15823273 (5), 19758589 (2), 15319264 (1), 18647594 (1) (see all 9)
breast cancer	31.2	39	16004819 (6), 17706116 (3), 18035727 (3), 9154157 (3) (see all 19)
breast carcinoma	30.9	9	19176383 (2), 20021962 (1), 16443928 (1), 10355528 (1)

Human Genome Epidemiology (HuGE) Navigator: BSG (4 documents)

Export disorders for BSG gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for BSG gene, integrated from 9 sources (see all 531):
(articles sorted by number of sources associating them with BSG)

Utopia: connect your pdf to the dynamic
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The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily. (PubMed id 7812975)^{1, 2, 3, 9} Biswas C....Nabeshima K. (1995)
Basigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion. (PubMed id 12792908)^{1, 2, 9} Muramatsu T. and Miyauchi T. (2003)
Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin, and chicken HT7 molecule. (PubMed id 1634773)^{1, 2, 9} Kasinrerk W....Stockinger H. (1992)
Partial sequencing and characterization of the tumor cell-derived collagenase stimulatory factor. (PubMed id 1846736)^{1, 2, 9} Nabeshima K.... Biswas C. (1991)
Characterization of the gene for human EMMPRIN, a tumor cell surface inducer of matrix metalloproteinases. (PubMed id 9767135)^{1, 2, 9} Guo H.... Gordon M.K. (1998)
The basigin group of the immunoglobulin superfamily: complete conservation of a segment in and around transmembrane domains of human and mouse basigin and chicken HT7 antigen. (PubMed id 1783610)^{1, 2, 9} Miyauchi T.... Muramatsu T. (1991)
Characterization of basigin isoforms and the inhibito ry function of basigin-3 in human hepatocellular carcinoma proliferation and in vasion. (PubMed id 21536654)^{1, 2} Liao C.G....Chen Z.N. (2011)
Structure of the EMMPRIN N-terminal domain 1: dimerization via beta- strand swapping. (PubMed id 19768682)^{1, 2} Luo J.... Gilliland G.L. (2009)
Crystal structure of HAb18G/CD147: implications for immunoglobulin superfamily homophilic adhesion. (PubMed id 18430721)^{1, 2} Yu X.-L.... Chen Z.-N. (2008)
junction protein shrew-1 influences cell invasion and interacts with invasion-promoting protein CD147. (PubMed id 17267690)^{1, 2} Schreiner A....Starzinski-Powitz A. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 682	HGNC: 1116	AceView: BSG	Ensembl:ENSG00000172270	euGenes: HUgn682
ECgene: BSG	H-InvDB: BSG

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for BSG	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for BSG	Genetics and Cytogenetics in Oncology and Haematology
dbRBC/BGMUT	http://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=ok
SeattleSNPs	http://pga.gs.washington.edu/data/bsg/

Intellectual Property for BSG gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for BSG gene:
Search GeneIP for patents involving BSG

GeneCards and IP:
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basigin (Ok blood group)

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