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BSG Gene

protein-coding GIFtS: 65

GC19P000522

basigin (Ok blood group)
(Previous name: basigin (OK blood group) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: OK)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
5F7 ^², ³
CD147 ^¹, ²
EMMPRIN ^¹, ², ³
M6 ^²
OK ^²
TCSF ^², ³
basigin ^²

Descriptions
CD147 antigen ^², ³
Collagenase stimulatory factor ^², ³
Extracellular matrix metalloproteinase inducer ^², ³
Leukocyte activation antigen M6 ^³
M6 leukocyte activation antigen ^²
OK blood group antigen ^², ³
Tumor cell-derived collagenase stimulatory factor ^³
basigin (Ok blood group) ^¹, ²

External Ids
HGNC: 1116¹
Entrez Gene: 682²
UniProtKB: P35613³
Ensembl: ENSG00000172270⁷

Search outside databases for aliases for BSG gene

Previous GC identifers: GC19P000624 GC19P000511 GC19P000523 GC19P000462

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for BSG:

The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis,

embryo implantation, neural network formation, and tumor progression. The encoded protein is also

a member of the immunoglobulin superfamily. Multiple transcript variants encoding different

isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: BASI_HUMAN, P35613

Function: Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and

tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS).

May target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of

retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans.

In vitro, promotes outgrowth of astrocytic processes (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the BSG gene

Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3

BSG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P000522: (about GC identifiers)

Start:	522,325 bp from pter
End:	534,493 bp from pter
Size:	12,169 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000019.8 NT_011255.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: BASI_HUMAN, P35613 (See protein sequence)

Recommended Name: Basigin precursor

Size: 385 amino acids; 42200 Da

Subunit: Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms a complex with

MMP1 at the tumor cell surface. Interacts with SLC16A1 and SLC1A3; probably a BSG dimer is

associated with a monocarboxylate transporter dimer. Interacts with ATP1B2, MAG and L1CAM (By

similarity). Interacts with AJAP1

Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity).

Melanosome. Note=Colocalizes with SLC16A1 and SLC16A8 (By similarity). Identified by mass

spectrometry in melanosome fractions from stage I to stage IV

PDB structures from and Proteopedia :

3B5H (3D)

Secondary accessions: Q7Z796 Q8IZL7

Alternative splicing: 2 isoforms: P35613-1 P35613-2

Post-translational modifications:

N-glycosylated¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_001719.2 NP_940991.1 NP_940992.1 NP_940993.1

ENSEMBL proteins:

ENSP00000379333 ENSP00000333769 ENSP00000343809 ENSP00000344707

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for BSG (EMMPRIN/CD147)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (CD147)
	Human Recombinant Proteins from Abnova (BSG)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	EXP	14707126 15946952
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--
GO:0042470	melanosome	IEA	--

About this table

Antibodies for BSG:

	Invitrogen Antibodies for BSG
	Millipore Mono- and Polyclonal Antibodies for the study of BSG
	Sigma-Aldrich Antibodies for BSG
	R&D Systems Antibodies for BSG (EMMPRIN/CD147, TRA-1-85)
	Antibodies from Abcam (CD147), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (BSG)
	Novus Biologicals Antibodies for BSG

Assays for BSG:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for BSG (EMMPRIN/CD147) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P35613

ProtoNet protein and cluster: P35613

2 Blocks protein families:

IPB003598 Immunoglobulin C-2 type

IPB003599 Immunoglobulin subtype

UniProtKB/Swiss-Prot: BASI_HUMAN, P35613

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BSG)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_198589

Applied Biosystems Silencer® siRNAs for BSG

Sigma-Aldrich siRNA and siRNA Panels for BSG

Sigma-Aldrich shRNA for BSG

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for BSG
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001728
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001728
untagged cDNA clones in CMV expression vector (see all 4): NM_001728

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001728

UniProtKB/Swiss-Prot: BASI_HUMAN, P35613

Function: Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and

tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS).

May target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of

retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans.

In vitro, promotes outgrowth of astrocytic processes (By similarity)

Induction: Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels

correlate with malignant potential of the tumor

Genatlas biochemistry entry for BSG:

basigin,widely expressed,involved in cell recognition,broadly expressed on hematopoietic cells

stimulating nearly fibroblasts to synthesize matrix metalloproteinases,member of the Ig

superfamily

7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Bsg):

growth/size	immune system	lethality-postnatal	lethality-prenatal/perinatal	liver/biliary system
reproductive system	respiratory system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	17353931
GO:0005529	sugar binding	IEA	--
GO:0005537	mannose binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for BSG

5/44 Interacting proteins for BSG (ENSP00000333769³ P35613^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 44 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATXN10	Q9UBB4¹	EBI-750709, EBI-702390
RANBP3	Q9H6Z4¹	EBI-750709, EBI-992681
RFXANK	O14593¹	EBI-750709, EBI-1057665
PDLIM7	Q9NR12²	MINT-67881
PPIA	ENSP00000348240³	STRING (score=.999)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007166	cell surface receptor linked signal transduction	TAS	9767135

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for BSG
10/14 Novoseek chemical compound relationships for BSG gene (see all 14 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
prinomastat	74.78	2	11726397 (1)
gw9662	50.83	1	17007354 (1)
heparan sulfate	26.64	4	17267519 (2), 14557624 (1), 17540735 (1)
matrigel	19.62	1	1662201 (1)
phosphoinositide	18.75	1	16778084 (1)
pyruvate	9.04	1	17196136 (1)
cytochalasin b	7.56	2	11402500 (1)
tyrosine	3.44	6	15215314 (1), 11435306 (1), 11402500 (1), 18088478 (1) (see all 6)
progesterone	1.65	4	14671212 (2), 18216291 (1), 15161697 (1)
sucrose	0.00	3	14707126 (1), 10611479 (1), 18048771 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BSG)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_198589

Sigma-Aldrich siRNA and siRNA Panels for BSG

Sigma-Aldrich shRNA for BSG

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001728 NM_198589 NM_198591

REFSEQ mRNAs for BSG gene (4 alternative transcripts):

NM_001728.2 NM_198589.1 NM_198590.1 NM_198591.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001728 NM_198589 NM_198591

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001728
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001728
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001728

Additional cDNA sequence:

AB072923.1 AB085790.1 AB091680.1 AF548371.1 AK296858.1 AK297880.1 AK302231.1 AY358113.1

BC009040.2 CR591697.1 CR591998.1 CR592900.1 CR595656.1 CR595925.1 CR596692.1 CR597284.1

CR597832.1 CR600626.1 CR601862.1 CR602687.1 CR603442.1 CR609558.1 CR609700.1 CR611405.1

CR611864.1 CR611929.1 CR614422.1 CR615555.1 CR616379.1 CR619238.1 CR619245.1 CR622629.1

CR623986.1 CR626008.1 D45131.1 L10240.1 L20471.1 M87879.1 X64364.1

24/66 DOTS entries (see all 66 ):

DT.91668770 DT.453436 DT.121413366 DT.100888619 DT.100759067 DT.100888658 DT.121413196 DT.95301640

DT.100888653 DT.100888660 DT.91804848 DT.91642062 DT.100700252 DT.95161666 DT.121413247 DT.100888564

DT.100888620 DT.102843970 DT.100888633 DT.100888612 DT.100888566 DT.97861008 DT.95161635 DT.100888568

24/1946 AceView cDNA sequences (see all 1946 ):

BQ681256 BQ637997 BM550835 BM683116 BG743280 AJ705916 BF725948 BU631051

BM792885 BF338438 BQ637057 CR595925 BM928656 CA305885 BP360576 CR619245

BM759508 CB153014 BQ649733 CR623986 CR611405 CR626008 BQ639433 CR609558

highest scoring ESTs for BSG:

X64364 AA043716 AA082997 AA098964 AA121149 AA158314 AA158315 AA181131 AA191716 AA232311

Unigene Cluster for BSG:

Basigin (Ok blood group)

Hs.501293 [show with all ESTs]

Unigene Representative Sequence: NM_001728

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for BSG (see all 13 )

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	·	2d	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	·	5d	·	5e	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	·	8c	·	8d	^	9	^	10	^	11a	·	11b	·
SP1:													-				-		-												-
SP2:													-		-		-		-												-
SP3:													-		-		-		-												-
SP4:																															-
SP5:					-		-		-		-		-		-		-		-												-

ExUns:	11c
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for BSG

4 Ensembl transcripts including schematic representations:

ENST00000396012 ENST00000333511 ENST00000353555 ENST00000346916

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

BSG expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for BSG

¹ / ² / ³

3 probe-sets matching BSG gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36162_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X64364	1.00	1.00	1.00	1
208677_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL550657	0.60	1.00	0.82	1
208677_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCCGGGTGGG

SOURCE GeneReport for Unigene cluster: Hs.501293
Expression variation in blood from EXPOLDB for BSG
UniProtKB/Swiss-Prot: BASI_HUMAN, P35613
Tissue specificity: Present only in vascular endothelium in non-neoplastic regions of the brain,
whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for BSG gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
rat (Rattus norvegicus)	Bsg¹	--	basigin	71.54(n) 59.35(a)	25246 NM_012783.2 NP_036915.1
mouse (Mus musculus)	Bsg^{1, 5}	10 (42.40 cM)⁵	basigin^{1, 5}	72.47(n)¹ 65.71(a)¹	12215¹ NM_009768.2¹ NP_033898.1¹ AI115436⁵ AI325119⁵ (see all 31)
zebrafish (Danio rerio)	BI562797.1²	--	--	76.72(n)	BI562797.1
African clawed frog (Xenopus laevis)	BU906264.1²	--	--	75.29(n)	BU906264.1
rainbow trout (Oncorhynchus mykiss)	Omy.2134²	--	Oncorhynchus mykiss transcribed sequence with weak more	78.46(n)	BX074917.1

About this table Species with no ortholog for BSG

ENSEMBL Gene Tree for BSG

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for BSG gene

NPTN² EMB²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1616 NCBI SNPs in BSG are shown (see all 1616 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 117)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4919859^1,2	A,C,F,H	523317(+)	`TCATTG/CCAACT`	3	--	int¹ ng5¹		8		MN EA NS EU WA	1746
--	rs10422496^1,2	A,C,H	521357(+)	`ttcatC/Tatcgt`	1	--	ng5¹		4		EU EA WA	388
	rs8637^1,2	C,F,H	533775(+)	`GCTCCG/ACGTCT`	3	--	ut3¹ ese³		10		MN EA NS EU WA	2414
	rs13676^1,2	A,C,F	534268(+)	`ACCCCG/ATCACA`	3	--	ut3¹ ese³		3		MN NS	278
	rs1049676^1,2	A,C,F	534450(+)	`CCCCTC/TCCACC`	3	--	ut3¹ trp³		2		NS	94
	rs6758^1,2	A,C,F	534460(+)	`CCACCG/ACCACA`	3	--	ut3¹ ese³		4		MN EA NS	1089
	rs8259^1,2	A,C,F	533927(-)	`AAAAAT/ACCTAA`	3	--	ut3¹ ese³ trp³		6		EA MN NS	1572
--	rs6757^1,2	A,C,F	534418(+)	`CTCTCT/CATAGC`	3	--	ut3¹ ese³		4		MN EA NS	1782
	rs2238546^1,2	C,F	534698(+)	`ACTTGG/AAAGGT`	3	--	ng3¹		2		NS	92
--	rs10401448^1,2	A,C	521193(+)	`ttgccC/Gaggct`	1	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for BSG (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 109480 disorders: 111380

10/69 Novoseek disease relationships for BSG gene (see all 69 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis	58.47	72	11992541 (5), 18223224 (3), 16004819 (3), 14613643 (3) (see all 33)
tumors	56.55	351	15833850 (8), 16633062 (6), 14985463 (6), 16721788 (5) (see all 99)
stromal tumors	46.51	1	15833850 (1)
laryngeal squamous cell carcinoma	45.47	6	16176007 (5), 18431027 (1)
carcinoma	44.69	27	14983875 (3), 19105397 (2), 16633062 (1), 15632176 (1) (see all 19)
cancer	43.80	130	11395366 (4), 16443928 (3), 18508606 (3), 14983875 (2) (see all 50)
atherosclerotic plaque	33.97	14	15823273 (5), 15319264 (1), 18647594 (1), 16182316 (1) (see all 6)
ameloblastoma	32.20	11	19079990 (5), 11474447 (2), 16762015 (1)
breast cancer	29.94	35	16004819 (6), 17706116 (3), 9154157 (3), 18035727 (3) (see all 17)
ovarian carcinoma	29.15	9	12705637 (3), 17460779 (2), 12684413 (1), 14669793 (1)

About this table

Blood Group Antigen Gene Mutation Database (BGMUT) Ok blood group system

Human Gene Mutation Database: BSG

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/339 PubMed articles for BSG gene (see all 339 ):

The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily. (PubMed id 7812975)^{1, 2, 3, 4} Biswas C....Nabeshima K. (1995)
Basigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion. (PubMed id 12792908)^{1, 3, 4} Muramatsu T. and Miyauchi T. (2003)
Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin, and chicken HT7 molecule. (PubMed id 1634773)^{1, 3, 4} Kasinrerk W....Stockinger H. (1992)
Partial sequencing and characterization of the tumor cell-derived collagenase stimulatory factor. (PubMed id 1846736)^{1, 3, 4} Nabeshima K.... Biswas C. (1991)
The Ok(a) blood group antigen is a marker for the M6 leukocyte activation antigen, the human homolog of OX-47 antigen, basigin and neurothelin, an immunoglobulin superfamily molecule that is widely expressed in human cells and tissues. (PubMed id 9130641)^{1, 3, 4} Spring F.A.... Parsons S.F. (1997)
The basigin group of the immunoglobulin superfamily: complete conservation of a segment in and around transmembrane domains of human and mouse basigin and chicken HT7 antigen. (PubMed id 1783610)^{1, 3, 4} Miyauchi T.... Muramatsu T. (1991)
Characterization of the gene for human EMMPRIN, a tumor cell surface inducer of matrix metalloproteinases. (PubMed id 9767135)^{1, 3, 4} Guo H.... Gordon M.K. (1998)
junction protein shrew-1 influences cell invasion and interacts with invasion-promoting protein CD147. (PubMed id 17267690)^{3, 4} Schreiner A....Starzinski-Powitz A. (2007)
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)^{3, 4} Chi A....Hunt D.F. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 682	HGNC: 1116	AceView: BSG	Ensembl:ENSG00000172270	euGenes: HUgn682
ECgene: BSG	H-InvDB: BSG

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for BSG	Genetics and Cytogenetics in Oncology and Haematology
dbRBC/BGMUT	http://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=ok
SeattleSNPs	http://pga.gs.washington.edu/data/bsg/

Licensable Technologies for BSG
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for BSG:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for BSG-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for BSG		Antibodies for BSG
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for BSG		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (BSG)
	Antibodies (BSG)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (CD147)
	Antibodies (CD147)

Search OriGene for BSG

Search Tocris compounds for BSG

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for BSG

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
BSG Gene at Home site.
Version 2.41.1
server5.xennexinc.com

BSG Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for BSG

Summaries
for BSG

Genomic Location
for BSG

Proteins
for BSG

Protein Domains/
Families
for BSG

Gene Function
for BSG

Pathways & Interactions
for BSG

Drugs & Compounds
for BSG

Transcripts
for BSG

Expression
for BSG

Orthologs
for BSG

Paralogs
for BSG

SNPs/Variants
for BSG

Disorders & Mutations
for BSG

Medical News
for BSG

Publications
for BSG

Search for BSG

Genome Databases showing BSG

Other Databases showing BSG

Specialized Databases showing BSG

Licensable Technologies
for BSG

Services
for BSG

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

BSG Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor BSG

Summariesfor BSG

Genomic Locationfor BSG

Proteinsfor BSG

Protein Domains/Familiesfor BSG

Gene Functionfor BSG

Pathways & Interactionsfor BSG

Drugs & Compoundsfor BSG

Transcriptsfor BSG

Expression for BSG

Orthologsfor BSG

Paralogsfor BSG

SNPs/Variantsfor BSG

Disorders & Mutationsfor BSG

Medical Newsfor BSG

Publicationsfor BSG

Search for BSG

Genome Databases showing BSG

Other Databases showing BSG

Specialized Databases showing BSG

Licensable Technologiesfor BSG

Servicesfor BSG

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for BSG

Summaries
for BSG

Genomic Location
for BSG

Proteins
for BSG

Protein Domains/
Families
for BSG

Gene Function
for BSG

Pathways & Interactions
for BSG

Drugs & Compounds
for BSG

Transcripts
for BSG

Expression
for BSG

Orthologs
for BSG

Paralogs
for BSG

SNPs/Variants
for BSG

Disorders & Mutations
for BSG

Medical News
for BSG

Publications
for BSG

Licensable Technologies
for BSG

Services
for BSG