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Aliases for BSG Gene

Aliases for BSG Gene

  • Basigin (Ok Blood Group) 2 3 5
  • Tumor Cell-Derived Collagenase Stimulatory Factor 3 4
  • Extracellular Matrix Metalloproteinase Inducer 3 4
  • Leukocyte Activation Antigen M6 3 4
  • Collagenase Stimulatory Factor 3 4
  • OK Blood Group Antigen 3 4
  • Basigin 2 3
  • EMMPRIN 3 4
  • TCSF 3 4
  • 5F7 3 4
  • Ok Blood Group 2
  • CD147 Antigen 4
  • CD147 3
  • OK 3

External Ids for BSG Gene

Previous HGNC Symbols for BSG Gene

  • OK

Previous GeneCards Identifiers for BSG Gene

  • GC19P000624
  • GC19P000511
  • GC19P000523
  • GC19P000522
  • GC19P000462
  • GC19P000342

Summaries for BSG Gene

Entrez Gene Summary for BSG Gene

  • The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for BSG Gene

BSG (Basigin (Ok Blood Group)) is a Protein Coding gene. Diseases associated with BSG include Brain Stem Cancer and Brain Stem Glioma. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include mannose binding. An important paralog of this gene is NPTN.

UniProtKB/Swiss-Prot for BSG Gene

  • Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3, SLC16A8 and SLC16A11 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.

Gene Wiki entry for BSG Gene

Additional gene information for BSG Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BSG Gene

Genomics for BSG Gene

GeneHancer (GH) Regulatory Elements for BSG Gene

Promoters and enhancers for BSG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I000569 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 560.7 +2.0 2047 7.4 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 LOC105372233 BSG GC19P000573 GC19P000572 TMEM259 DAZAP1 PTBP1 ENSG00000267317 SBNO2 MED16
GH19I000516 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.8 -53.1 -53086 3.3 HDGF ATF1 ARNT TCF12 GATA2 ATF7 ZNF263 NCOA1 ZNF592 SNIP1 DAZAP1 TMEM259 CFD MIER2 PTBP1 BSG MED16 ENSG00000267317 RNF126 GRIN3B
GH19I000588 Enhancer 1.1 ENCODE dbSUPER 9.5 +17.0 17039 0.2 NFIB ARID4B KLF17 SIN3A ZNF2 ZNF48 RAD21 ZNF335 GLIS2 ZNF143 HCN2 GC19P000592 GC19P000591 BSG CDC34 GC19M000583
GH19I000514 Enhancer 0.6 dbSUPER 11.8 -56.7 -56671 1.1 SMARCA5 BCOR ZNF792 ZMYM3 PYGO2 CDC5L ZBTB40 ZKSCAN1 ZKSCAN8 ADNP BSG TPGS1 LOC105372232 CDC34
GH19I000566 Enhancer 1.1 Ensembl ENCODE 6.1 -4.1 -4076 2.4 PKNOX1 ARID4B TCF12 CBX5 GATA2 ATF7 SP5 NCOA1 REST NFIL3 LOC105372233 POLRMT FGF22 BSG PIR53036
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around BSG on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the BSG gene promoter:

Genomic Locations for BSG Gene

Genomic Locations for BSG Gene
chr19:571,277-583,493
(GRCh38/hg38)
Size:
12,217 bases
Orientation:
Plus strand
chr19:571,297-583,493
(GRCh37/hg19)

Genomic View for BSG Gene

Genes around BSG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BSG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BSG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BSG Gene

Proteins for BSG Gene

  • Protein details for BSG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35613-BASI_HUMAN
    Recommended name:
    Basigin
    Protein Accession:
    P35613
    Secondary Accessions:
    • A6NJW1
    • D3YLG5
    • Q7Z796
    • Q8IZL7

    Protein attributes for BSG Gene

    Size:
    385 amino acids
    Molecular mass:
    42200 Da
    Quaternary structure:
    • Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms heterooligomers of isoform 2 and isoform 3. Forms a complex with MMP1 at the tumor cell surface. Interacts with ATP1B2, MAG and L1CAM (By similarity). Interacts with AJAP1. Interacts with SLC16A1, SLC16A7 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with PPIL2; regulates BSG transport to the cell membrane. Interacts with SLC16A11 (PubMed:28666119).

    Three dimensional structures from OCA and Proteopedia for BSG Gene

    Alternative splice isoforms for BSG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BSG Gene

Post-translational modifications for BSG Gene

  • N-glycosylated.
  • Ubiquitination at posLast=173173, posLast=179179, posLast=227227, Lys243, Lys257, and Lys307
  • Glycosylation at posLast=145145, posLast=160160, posLast=268268, and posLast=302302

No data available for DME Specific Peptides for BSG Gene

Domains & Families for BSG Gene

Gene Families for BSG Gene

HGNC:
Human Protein Atlas (HPA):
  • Blood group antigen proteins
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins
  • Transporters

Suggested Antigen Peptide Sequences for BSG Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BSG: view

No data available for UniProtKB/Swiss-Prot for BSG Gene

Function for BSG Gene

Molecular function for BSG Gene

GENATLAS Biochemistry:
basigin,widely expressed,involved in cell recognition,broadly expressed on hematopoietic cells stimulating nearly fibroblasts to synthesize matrix metalloproteinases,member of the Ig superfamily
UniProtKB/Swiss-Prot Function:
Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3, SLC16A8 and SLC16A11 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.
UniProtKB/Swiss-Prot Induction:
Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with malignant potential of the tumor.

Phenotypes From GWAS Catalog for BSG Gene

Gene Ontology (GO) - Molecular Function for BSG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15946952
GO:0005537 mannose binding IEA --
GO:0008028 monocarboxylic acid transmembrane transporter activity TAS --
GO:0030246 carbohydrate binding IEA --
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with BSG: view
genes like me logo Genes that share phenotypes with BSG: view

Animal Models for BSG Gene

MGI Knock Outs for BSG:

Clone Products

  • Addgene plasmids for BSG

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BSG Gene

Localization for BSG Gene

Subcellular locations from UniProtKB/Swiss-Prot for BSG Gene

Cell membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In spermatozoa, localized on the principal piece of caput and in the middle piece during transit in the corpus and cauda epididymides (By similarity). {ECO:0000250 UniProtKB:P18572, ECO:0000269 PubMed:17081065}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BSG gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 5
golgi apparatus 5
cytoskeleton 2
endoplasmic reticulum 2
lysosome 2
endosome 2
peroxisome 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for BSG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0002080 acrosomal membrane IEA --
GO:0005739 mitochondrion IDA,HDA 20833797
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane ISS --
genes like me logo Genes that share ontologies with BSG: view

Pathways & Interactions for BSG Gene

genes like me logo Genes that share pathways with BSG: view

Pathways by source for BSG Gene

Gene Ontology (GO) - Biological Process for BSG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006090 pyruvate metabolic process TAS --
GO:0007166 cell surface receptor signaling pathway TAS 9767135
GO:0007566 embryo implantation IEA --
GO:0015718 monocarboxylic acid transport IEA --
GO:0022617 extracellular matrix disassembly TAS --
genes like me logo Genes that share ontologies with BSG: view

No data available for SIGNOR curated interactions for BSG Gene

Drugs & Compounds for BSG Gene

(18) Drugs for BSG Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(9) Additional Compounds for BSG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BSG: view

Transcripts for BSG Gene

Unigene Clusters for BSG Gene

Basigin (Ok blood group):
Representative Sequences:

Clone Products

  • Addgene plasmids for BSG

Alternative Splicing Database (ASD) splice patterns (SP) for BSG Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b ·
SP1: - - - -
SP2: - - - - -
SP3: - - - - -
SP4: -
SP5: - - - - - - - - -
SP6: - - - - - -
SP7: - - - - - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - -
SP10: - - - -
SP11: - - - - - - - - - -
SP12: - -
SP13: -

ExUns: 11c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for BSG Gene

GeneLoc Exon Structure for
BSG
ECgene alternative splicing isoforms for
BSG

Expression for BSG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BSG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BSG Gene

This gene is overexpressed in Heart - Left Ventricle (x4.2).

Protein differential expression in normal tissues from HIPED for BSG Gene

This gene is overexpressed in Nasal epithelium (13.1) and Retina (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BSG Gene



Protein tissue co-expression partners for BSG Gene

NURSA nuclear receptor signaling pathways regulating expression of BSG Gene:

BSG

SOURCE GeneReport for Unigene cluster for BSG Gene:

Hs.501293

mRNA Expression by UniProt/SwissProt for BSG Gene:

P35613-BASI_HUMAN
Tissue specificity: Present only in vascular endothelium in non-neoplastic regions of the brain, whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas.

Evidence on tissue expression from TISSUES for BSG Gene

  • Nervous system(5)
  • Eye(4.9)
  • Liver(4.8)
  • Intestine(4.7)
  • Lung(4.7)
  • Skin(4.7)
  • Kidney(4.6)
  • Pancreas(4.3)
  • Heart(4)
  • Blood(3.6)
  • Muscle(3.6)
  • Thyroid gland(3.2)
  • Bone marrow(2.9)
  • Lymph node(2.9)
  • Stomach(2.9)
  • Bone(2.5)
  • Spleen(2.4)
  • Adrenal gland(2.2)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with BSG: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for BSG Gene

Orthologs for BSG Gene

This gene was present in the common ancestor of animals.

Orthologs for BSG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BSG 33 34
  • 96.24 (n)
rat
(Rattus norvegicus)
Mammalia Bsg 33
  • 74.72 (n)
mouse
(Mus musculus)
Mammalia Bsg 33 16 34
  • 72.47 (n)
cow
(Bos Taurus)
Mammalia BSG 34
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BSG 34
  • 57 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BSG 34
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BSG 34
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves BSG 33 34
  • 63.49 (n)
lizard
(Anolis carolinensis)
Reptilia BSG 34
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii bsg 33 34
  • 57.43 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2134 33
fruit fly
(Drosophila melanogaster)
Insecta Bsg 34
  • 10 (a)
OneToMany
Species where no ortholog for BSG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BSG Gene

ENSEMBL:
Gene Tree for BSG (if available)
TreeFam:
Gene Tree for BSG (if available)

Paralogs for BSG Gene

Paralogs for BSG Gene

(3) SIMAP similar genes for BSG Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with BSG: view

Variants for BSG Gene

Sequence variations from dbSNP and Humsavar for BSG Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs104894669 affects, BLOOD GROUP--OK 580,428(+) G/A 5_prime_UTR_variant, coding_sequence_variant, missense_variant
rs1000016233 -- 581,946(+) G/A intron_variant
rs1000243523 -- 577,797(+) T/A coding_sequence_variant, intron_variant, missense_variant
rs1000473547 -- 571,748(+) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000686219 -- 580,195(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for BSG Gene

Variant ID Type Subtype PubMed ID
dgv6174n54 CNV loss 21841781
dgv6175n54 CNV loss 21841781
esv2717744 CNV deletion 23290073
esv3643354 CNV loss 21293372
esv3643355 CNV gain 21293372
nsv428360 CNV gain 18775914
nsv470101 CNV loss 18288195
nsv577978 CNV gain 21841781
nsv578151 CNV loss 21841781
nsv578152 CNV gain 21841781
nsv578153 CNV loss 21841781
nsv578154 CNV loss 21841781
nsv578157 CNV gain 21841781
nsv578159 CNV loss 21841781
nsv578160 CNV loss 21841781
nsv953938 CNV deletion 24416366

Variation tolerance for BSG Gene

Residual Variation Intolerance Score: 25.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.65; 31.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for BSG Gene

Human Gene Mutation Database (HGMD)
BSG
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group System
SNPedia medical, phenotypic, and genealogical associations of SNPs for
BSG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BSG Gene

Disorders for BSG Gene

MalaCards: The human disease database

(15) MalaCards diseases for BSG Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
brain stem cancer
  • malignant neoplasm of brain stem
brain stem glioma
  • brainstem neuroglial tumor
ameloblastoma
  • adenoameloblastoma
accommodative esotropia
  • esotropia with accommodative compensation
necrotizing ulcerative gingivitis
  • acute necrotising ulcerative gingivitis
- elite association - COSMIC cancer census association via MalaCards
Search BSG in MalaCards View complete list of genes associated with diseases

Additional Disease Information for BSG

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with BSG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BSG Gene

Publications for BSG Gene

  1. The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily. (PMID: 7812975) Biswas C … Nabeshima K (Cancer research 1995) 2 3 4 22 58
  2. The role of charged residues in the transmembrane helices of monocarboxylate transporter 1 and its ancillary protein basigin in determining plasma membrane expression and catalytic activity. (PMID: 17127621) Manoharan C … Halestrap AP (Molecular membrane biology 2006) 3 4 22 58
  3. Cell surface expression of CD147/EMMPRIN is regulated by cyclophilin 60. (PMID: 15946952) Pushkarsky T … Bukrinsky MI (The Journal of biological chemistry 2005) 3 4 22 58
  4. Basigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion. (PMID: 12792908) Muramatsu T … Miyauchi T (Histology and histopathology 2003) 3 4 22 58
  5. Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin, and chicken HT7 molecule. (PMID: 1634773) Kasinrerk W … Stockinger H (Journal of immunology (Baltimore, Md. : 1950) 1992) 3 4 22 58

Products for BSG Gene

Sources for BSG Gene

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