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BSG Gene

protein-coding   GIFtS: 68
GCID: GC19P000571

Basigin (Ok Blood Group)

(Previous name: basigin)
(Previous symbol: OK)
  See BSG-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Basigin (Ok Blood Group)1 2     EMMPRIN2 3
OK1 2     TCSF2 3
basigin1 2     CD147 Antigen2 3
Collagenase Stimulatory Factor2 3     OK Blood Group Antigen2 3
Extracellular Matrix Metalloproteinase Inducer2 3     Ok Blood Group1
Leukocyte Activation Antigen M62 3     CD1472
Tumor Cell-Derived Collagenase Stimulatory Factor2 3     M62
5F72 3     

External Ids:    HGNC: 11161   Entrez Gene: 6822   Ensembl: ENSG000001722707   OMIM: 1094805   UniProtKB: P356133   

Export aliases for BSG gene to outside databases

Previous GC identifers: GC19P000624 GC19P000511 GC19P000523 GC19P000522 GC19P000462 GC19P000342


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BSG Gene:
The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo
implantation, neural network formation, and tumor progression. The encoded protein is also a member of the
immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for BSG Gene:
BSG (basigin (Ok blood group)) is a protein-coding gene. Diseases associated with BSG include spinal cord astrocytoma, and brain stem glioma. GO annotations related to this gene include mannose binding. An important paralog of this gene is NPTN.

UniProtKB/Swiss-Prot: BASI_HUMAN, P35613
Function: Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to
the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and
tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a
receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes

Gene Wiki entry for BSG (Basigin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BSG gene promoter:
         AP-1   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): BSG promoter sequence
   Search Chromatin IP Primers for BSG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BSG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

BSG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BSG gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P000571:  view genomic region     (about GC identifiers)

Start:
571,297 bp from pter      End:
583,493 bp from pter
Size:
12,197 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: BASI_HUMAN, P35613 (See protein sequence)
Recommended Name: Basigin precursor  
Size: 385 amino acids; 42200 Da
Subunit: Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms heterooligomers of isoform 2
and isoform 3. Forms a complex with MMP1 at the tumor cell surface. Interacts with ATP1B2, MAG and L1CAM (By
similarity). Interacts with AJAP1. Interacts with SLC16A1, SLC16A7 and SLC1A3; probably a BSG dimer is associated
with a monocarboxylate transporter dimer
5 PDB 3D structures from and Proteopedia for BSG:
3B5H (3D)        3I84 (3D)        3I85 (3D)        3QQN (3D)        3QR2 (3D)    
Secondary accessions: A6NJW1 D3YLG5 Q7Z796 Q8IZL7
Alternative promoter usage, Alternative splicing: 4 isoforms:  P35613-1   P35613-2   P35613-3   P35613-4   (Produced by alternative promoter usage. N-glycosylated)

Explore the universe of human proteins at neXtProt for BSG: NX_P35613

Explore proteomics data for BSG at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Ubiquitination2 at Lys173, Lys179, Lys227, Lys243, Lys257, Lys264, Lys307
  • Glycosylation2 at Thr145, Asn160, Asn268, Asn302
  • Modification sites at PhosphoSitePlus

  • See BSG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001719.2  NP_940991.1  NP_940992.1  NP_940993.1  

    ENSEMBL proteins: 
     ENSP00000344707   ENSP00000473664   ENSP00000333769   ENSP00000458665   ENSP00000343809  
     ENSP00000473393   ENSP00000473528  
    Reactome Protein details: P35613

    BSG Human Recombinant Protein Products:

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    R&D Systems Recombinant & Natural Proteins for BSG (EMMPRIN/CD147)
    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for BSG
    OriGene MassSpec for BSG
    OriGene Custom Protein Services for BSG
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    Novus Biologicals BSG Proteins
    Novus Biologicals BSG Lysates
    Sino Biological Recombinant Protein for BSG
    Sino Biological Cell Lysate for BSG
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for BSG 

     
    antibodies-online proteins for BSG (5 products) 

     
    antibodies-online peptides for BSG

    BSG Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of BSG
    R&D Systems Antibodies for BSG (EMMPRIN/CD147, TRA-1-85/CD147)
    Cell Signaling Technology (CST) Antibodies for BSG 
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    OriGene Custom Antibody Services for BSG
    Novus Biologicals BSG Antibodies
    Abcam antibodies for BSG
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for BSG
    antibodies-online antibodies for BSG (2 products) 

    BSG Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for BSG (EMMPRIN/CD147)         (see all)
    GenScript Custom Assay Services for BSG
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for BSG 
    antibodies-online kits for BSG (48 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    bloodgroup: Blood group antigens
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    Selected InterPro protein domains (see all 6):
     IPR003598 Ig_sub2
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P35613

    ProtoNet protein and cluster: P35613

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB003599 Immunoglobulin subtype


    UniProtKB/Swiss-Prot: BASI_HUMAN, P35613
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with BSG           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BASI_HUMAN, P35613
    Function: Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to
    the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and
    tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a
    receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes
    Induction: Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with
    malignant potential of the tumor

         Genatlas biochemistry entry for BSG:
    basigin,widely expressed,involved in cell recognition,broadly expressed on hematopoietic cells stimulating nearly
    fibroblasts to synthesize matrix metalloproteinases,member of the Ig superfamily

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17127621
    GO:0005537mannose binding IEA--
         
    Find genes that share ontologies with BSG           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Bsg):
     growth/size/body  immune system  liver/biliary system  mortality/aging  reproductive system 
     respiratory system 

    Find genes that share phenotypes with BSG           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Bsgtm1Tmu for BSG

       genOway: Develop your customized and physiologically relevant rodent model for BSG

    miRNA
    Products:
        
    miRTarBase miRNAs that target BSG:
    hsa-mir-92a-3p (MIRT048970), hsa-mir-361-5p (MIRT044060), hsa-mir-328-3p (MIRT043789)

    Block miRNA regulation of human, mouse, rat BSG using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate BSG:
    hsa-miR-1324
    SwitchGear 3'UTR luciferase reporter plasmidBSG 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BSG
    Predesigned siRNA for gene silencing in human, mouse, rat BSG

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): BSG (NM_198589)
    Sino Biological Human cDNA Clone for BSG
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BSG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BSG
    Addgene plasmids for BSG 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for BSG 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BSG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BASI_HUMAN, P35613: Cell membrane; Single-pass type I membrane protein. Melanosome. Note=Colocalizes with
    SLC16A1 and SLC16A8 (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to
    stage IV
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    golgi apparatus4
    endoplasmic reticulum2
    extracellular2
    mitochondrion2
    cytoskeleton1
    lysosome1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0002080acrosomal membrane IEA--
    GO:0005739mitochondrion IDA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane ISS--

    Find genes that share ontologies with BSG           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BSG About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Citric acid cycle (TCA cycle)
    Pyruvate metabolism and Citric Acid (TCA) cycle0.49
    Pyruvate metabolism0.00
    2Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    3Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport0.71
    4Matrix Metalloproteinases
    Matrix Metalloproteinases0.68
    5Hemostasis
    Hemostasis0.43


    Find genes that share SuperPaths with BSG           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for BSG
        Adhesion

    2 BioSystems Pathways for BSG
        Matrix Metalloproteinases
    Syndecan-1-mediated signaling events


    4 Reactome Pathways for BSG
        Pyruvate metabolism
    Integrin cell surface interactions
    Degradation of the extracellular matrix
    Basigin interactions


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BSG
    Interactions:

        GeneGlobe Interaction Network for BSG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for BSG (P356132, 3 ENSP000003337694) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDLIM7Q9NR122, 3, ENSP000003480994MINT-67881 I2D: score=5 STRING: ENSP00000348099
    CAV1Q031353, ENSP000003391914I2D: score=2 STRING: ENSP00000339191
    MMP1P039563, ENSP000003227884I2D: score=2 STRING: ENSP00000322788
    PPIAP629373, ENSP000004194254I2D: score=2 STRING: ENSP00000419425
    RFXANKO145933, ENSP000003050714I2D: score=2 STRING: ENSP00000305071
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006090pyruvate metabolic process TAS--
    GO:0007166cell surface receptor signaling pathway TAS9767135
    GO:0007566embryo implantation IEA--
    GO:0007596blood coagulation TAS--
    GO:0022617extracellular matrix disassembly TAS--

    Find genes that share ontologies with BSG           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BSG (BASI)

    Selected Novoseek inferred chemical compound relationships for BSG gene (see all 27)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prinomastat 73.3 2 11726397 (1)
    gw9662 45.7 1 17007354 (1)
    vegf 39 53 17633444 (7), 19837976 (5), 15833850 (5), 16778084 (4) (see all 16)
    lactate 35.1 28 18761711 (3), 18778892 (2), 10921872 (2), 16434551 (2) (see all 15)
    sb 203580 29 1 9877171 (1)
    resveratrol 23.5 20 17007354 (7), 18647594 (6), 17055343 (5), 19561311 (1)
    heparan sulfate 23.2 4 17267519 (2), 14557624 (1), 17540735 (1)
    pioglitazone 20.4 5 17007354 (2), 17055343 (2), 16860414 (1)
    cyclosporin a 18.7 11 11353871 (3), 15946952 (2), 15671024 (1), 15732868 (1) (see all 5)
    cytochalasin b 17.7 2 11402500 (1)



    Find genes that share compounds with BSG           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BSG gene (4 alternative transcripts): 
    NM_001728.3  NM_198589.2  NM_198590.2  NM_198591.2  

    Unigene Cluster for BSG:

    Basigin (Ok blood group)
    Hs.501293  [show with all ESTs]
    Unigene Representative Sequence: NM_001728
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000346916(uc002loy.3) ENST00000545507(uc021ulx.1) ENST00000333511(uc002loz.3 uc002lpa.3)
    ENST00000576925 ENST00000573216 ENST00000353555 ENST00000590218 ENST00000572899
    ENST00000573784 ENST00000574970 ENST00000576984 ENST00000571735(uc002lpc.3)

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate BSG:
    hsa-miR-1324
    SwitchGear 3'UTR luciferase reporter plasmidBSG 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): BSG (NM_198589)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BSG
    Addgene plasmids for BSG 
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BSG
      QuantiTect SYBR Green Assays in human, mouse, rat BSG
      QuantiFast Probe-based Assays in human, mouse, rat BSG

    Additional mRNA sequence: 

    AB072923.1 AB085790.1 AB091680.1 AF548371.1 AK296858.1 AK297880.1 AK302231.1 AY358113.1 
    BC009040.2 D45131.1 GU557064.1 GU557065.1 L10240.1 L20471.1 M87879.1 X64364.1 

    Selected DOTS entries (see all 64):

    DT.91668770  DT.453436  DT.121413366  DT.100888619  DT.100759067  DT.100888658  DT.121413196  DT.95301640 
    DT.100888653  DT.91804848  DT.100888660  DT.91642062  DT.100700252  DT.95161666  DT.121413247  DT.100888564 
    DT.100888620  DT.102843970  DT.100888633  DT.100888612  DT.100888566  DT.97861008  DT.95161635  DT.100888568 

    Selected AceView cDNA sequences (see all 1946):

    AA365971 BU184042 AW575968 BQ676360 BM560927 BQ084324 CR597284 CD370300 
    CA439356 CA397421 AW239029 CR611405 CB152609 BF345646 BP362780 BM829049 
    CB112612 BF339063 CR591697 CF264973 BF312542 BM556981 AA300256 BQ637057 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BSG (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b ·
    SP1:                                      -           -     -                                   -                                                               
    SP2:                                      -     -     -     -                                   -                                                               
    SP3:                                      -     -     -     -                                   -                                                               
    SP4:                                                                                            -                                                               
    SP5:              -     -     -     -     -     -     -     -                                   -                                                               

    ExUns: 11c
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for BSG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    BSG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCGGGTGGG
    BSG Expression
    About this image


    BSG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 24) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Endothelium (Cardiovascular System)
             Endothelial Cells Blood Brain Barrier
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Limbal epithelial stem cells (family)
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Proerythroblasts Hematopoietic Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    BSG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BSG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.501293

    UniProtKB/Swiss-Prot: BASI_HUMAN, P35613
    Tissue specificity: Present only in vascular endothelium in non-neoplastic regions of the brain, whereas it is
    present in tumor cells but not in proliferating blood vessels in malignant gliomas

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BSG gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bsg1 , 5 basigin1, 5 72.47(n)1
    65.71(a)1
      10 (39.72 cM)5
    122151  NM_009768.21  NP_033898.11 
     797044915 
    chicken
    (Gallus gallus)
    Aves BSG1 basigin (Ok blood group) 63.49(n)
    55.29(a)
      770363  NM_001198990.2  NP_001185919.1 
    lizard
    (Anolis carolinensis)
    Reptilia BSG6
    basigin (Ok blood group)
    64(a)
    1 ↔ 1
    GL344297.1(45012-45362)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU906264.12   -- 75.29(n)    BU906264.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI562797.12   -- 76.72(n)    BI562797.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Bsg6
    Basigin
    10(a)
    1 → many
    2L(8083420-8116531)


    ENSEMBL Gene Tree for BSG (if available)
    TreeFam Gene Tree for BSG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BSG gene
    NPTN2  EMB2  
    3 SIMAP similar genes for BSG using alignment to 4 protein entries:     BASI_HUMAN (see all proteins):
    hEMMPRIN    NPTN    DKFZp566H1924

    Find genes that share paralogs with BSG           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BSG (see all 1955)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1048946691,2
    Cpathogenic1580428(+) TCCCCA/GAGCCC 7 K E mis1 ut510--------
    rs1379858951,2
    C--569308(+) TTCTT-/AATCTG 2 -- us2k10--------
    rs1432754601,2
    C--569324(+) TAAGTC/TTGTTT 2 -- us2k10--------
    rs1482509381,2
    C--569357(+) GGCGCA/GGTGGC 2 -- us2k10--------
    rs621326231,2
    C--569500(+) CGGGCA/GCCTGT 2 -- us2k13Minor allele frequency- G:0.17NA 6
    rs1507708421,2
    --569629(+) CTCCAA/CAAAAA 2 -- us2k10--------
    rs1174564401,2
    C,F--569654(+) TCATGT/CTTCCT 2 -- us2k11Minor allele frequency- C:0.07NA 120
    rs104084081,2
    C,H--569721(+) tccttT/Gtaatt 2 -- us2k113Minor allele frequency- G:0.06NA WA CSA EA 376
    rs1394528701,2
    --569738(+) TCTCCA/GAGATC 2 -- us2k10--------
    rs775496391,2
    C--569754(+) TGTTTC/TTTAGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for BSG (571297 - 583493 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for BSG (see all 43):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717744CNV Deletion23290073
    nsv910175CNV Loss21882294
    dgv3528n71CNV Loss21882294
    dgv3515n71CNV Loss21882294
    dgv3527n71CNV Loss21882294
    dgv3498n71CNV Loss21882294
    nsv910193CNV Loss21882294
    nsv910211CNV Loss21882294
    nsv910109CNV Loss21882294
    nsv910173CNV Loss21882294

    Human Gene Mutation Database (HGMD): BSG
    Locus Specific Mutation Databases (LSDB): BSG

    Blood Group Antigen Gene Mutation Database (BGMUT) blood group system
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BSG
    DNA2.0 Custom Variant and Variant Library Synthesis for BSG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 109480   
    OMIM disorders: 111380  
    2 diseases for BSG:    
    About MalaCards
    spinal cord astrocytoma    brain stem glioma

    2 diseases from the University of Copenhagen DISEASES database for BSG:
    Brain stem glioma     Carcinoma

    Find genes that share disorders with BSG           About GenesLikeMe

    Selected Novoseek inferred disease relationships for BSG gene (see all 71)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 61.6 101 11992541 (5), 19541433 (5), 18223224 (3), 16004819 (3) (see all 45)
    tumors 58 444 15833850 (8), 16633062 (6), 19569245 (6), 14985463 (6) (see all 99)
    carcinoma 46.6 36 14983875 (3), 19956835 (3), 19286191 (3), 19105397 (2) (see all 23)
    cancer 46.4 150 20199151 (5), 11395366 (4), 19597352 (3), 20406987 (3) (see all 57)
    chronic periodontitis 44.6 3 15853964 (1), 18315429 (1), 19515022 (1)
    stromal tumors 43 1 15833850 (1)
    laryngeal squamous cell carcinoma 42 6 16176007 (5), 18431027 (1)
    atherosclerotic plaque 38.7 22 15823273 (5), 19758589 (2), 15319264 (1), 18647594 (1) (see all 9)
    breast cancer 31.2 39 16004819 (6), 17706116 (3), 18035727 (3), 9154157 (3) (see all 19)
    breast carcinoma 30.9 9 19176383 (2), 20021962 (1), 16443928 (1), 10355528 (1)

    Genetic Association Database (GAD): BSG
    Human Genome Epidemiology (HuGE) Navigator: BSG (4 documents)

    Export disorders for BSG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BSG gene, integrated from 10 sources (see all 584):
    (articles sorted by number of sources associating them with BSG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily. (PubMed id 7812975)1, 2, 3, 9 Biswas C....Nabeshima K. (Cancer Res. 1995)
    2. Basigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion. (PubMed id 12792908)1, 2, 9 Muramatsu T. and Miyauchi T. (Histol. Histopathol. 2003)
    3. Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin, and chicken HT7 molecule. (PubMed id 1634773)1, 2, 9 Kasinrerk W....Stockinger H. (J. Immunol. 1992)
    4. Partial sequencing and characterization of the tumor cell-derived collagenase stimulatory factor. (PubMed id 1846736)1, 2, 9 Nabeshima K.... Biswas C. (Arch. Biochem. Biophys. 1991)
    5. The role of charged residues in the transmembrane helices of monocarboxylate transporter 1 and its ancillary protein basigin in determining plasma membrane expression and catalytic activity. (PubMed id 17127621)1, 2, 9 Manoharan C....Halestrap A.P. (Mol. Membr. Biol. 2006)
    6. Characterization of the gene for human EMMPRIN, a tumor cell surface inducer of matrix metalloproteinases. (PubMed id 9767135)1, 2, 9 Guo H.... Gordon M.K. (Gene 1998)
    7. The basigin group of the immunoglobulin superfamily: complete conservation of a segment in and around transmembrane domains of human and mouse basigin and chicken HT7 antigen. (PubMed id 1783610)1, 2, 9 Miyauchi T.... Muramatsu T. (J. Biochem. 1991)
    8. Characterization of basigin isoforms and the inhibitory function of basigin-3 in human hepatocellular carcinoma proliferation and invasion. (PubMed id 21536654)1, 2 Liao C.G....Chen Z.N. (Mol. Cell. Biol. 2011)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Structure of the EMMPRIN N-terminal domain 1: dimerization via beta- strand swapping. (PubMed id 19768682)1, 2 Luo J.... Gilliland G.L. (Proteins 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 682 HGNC: 1116 AceView: BSG Ensembl:ENSG00000172270 euGenes: HUgn682
    ECgene: BSG H-InvDB: BSG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BSG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BSG Genetics and Cytogenetics in Oncology and Haematology
    dbRBC/BGMUThttp://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=ok
    SeattleSNPshttp://pga.gs.washington.edu/data/bsg/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BSG gene:
    Search GeneIP for patents involving BSG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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