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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BSG Gene

protein-coding   GIFtS: 67
GCID: GC19P000571

Basigin

(Previous name: basigin (Ok blood group))
(Previous symbol: OK)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
basigin1 2     EMMPRIN2 3
OK1 2     TCSF2 3
Basigin (Ok Blood Group)1 2     CD147 Antigen2 3
Collagenase Stimulatory Factor2 3     OK Blood Group Antigen2 3
Extracellular Matrix Metalloproteinase Inducer2 3     Ok Blood Group1
Leukocyte Activation Antigen M62 3     CD1472
Tumor Cell-Derived Collagenase Stimulatory Factor2 3     M62
5F72 3     

External Ids:    HGNC: 11161   Entrez Gene: 6822   Ensembl: ENSG000001722707   OMIM: 1094805   UniProtKB: P356133   

Export aliases for BSG gene to outside databases

Previous GC identifers: GC19P000624 GC19P000511 GC19P000523 GC19P000522 GC19P000462 GC19P000342


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BSG Gene:
The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo
implantation, neural network formation, and tumor progression. The encoded protein is also a member of the
immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for BSG Gene: 
BSG (basigin) is a protein-coding gene. Diseases associated with BSG include spinal cord astrocytoma, and brain stem neoplasm, and among its related super-pathways are Pyruvate metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include protein binding and mannose binding. An important paralog of this gene is NPTN.

UniProtKB/Swiss-Prot: BASI_HUMAN, P35613
Function: Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor
progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target
monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and
neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic
processes (By similarity)

Gene Wiki entry for BSG (Basigin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011255.14  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BSG gene promoter:
         AP-1   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): BSG promoter sequence
   Search SABiosciences Chromatin IP Primers for BSG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BSG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

BSG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BSG gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P000571:  view genomic region     (about GC identifiers)

Start:
571,297 bp from pter      End:
583,493 bp from pter
Size:
12,197 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BASI_HUMAN, P35613 (See protein sequence)
Recommended Name: Basigin precursor  
Size: 385 amino acids; 42200 Da
Subunit: Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms heterooligomers of isoform 2
and isoform 3. Forms a complex with MMP1 at the tumor cell surface. Interacts with SLC16A1 and SLC1A3; probably a
BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with ATP1B2, MAG and L1CAM (By
similarity). Interacts with AJAP1
Subcellular location: Cell membrane; Single-pass type I membrane protein. Melanosome. Note=Colocalizes with
SLC16A1 and SLC16A8 (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to
stage IV
5 PDB 3D structures from and Proteopedia for BSG:
3B5H (3D)        3I84 (3D)        3I85 (3D)        3QQN (3D)        3QR2 (3D)    
Secondary accessions: A6NJW1 D3YLG5 Q7Z796 Q8IZL7
Alternative promoter usage, Alternative splicing: 4 isoforms:  P35613-1   P35613-2   P35613-3   P35613-4   (Produced by alternative promoter usage. N-glycosylated)

Explore the universe of human proteins at neXtProt for BSG: NX_P35613

Explore proteomics data for BSG at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P35613

  • BSG Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BSG Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001719.2  NP_940991.1  NP_940992.1  NP_940993.1  

    ENSEMBL proteins: 
     ENSP00000344707   ENSP00000473664   ENSP00000333769   ENSP00000458665   ENSP00000343809  
     ENSP00000473393   ENSP00000473528  
    Reactome Protein details: P35613
    Human Recombinant Protein Products for BSG: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for BSG (EMMPRIN/CD147)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for BSG
    OriGene Protein Over-expression Lysate for BSG
    OriGene MassSpec for BSG 
    OriGene Custom Protein Services for BSG
    GenScript Custom Purified and Recombinant Proteins Services for BSG
    Novus Biologicals BSG Proteins
    Novus Biologicals BSG Lysates
    Sino Biological Recombinant Protein for BSG
    Sino Biological Cell Lysate for BSG 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0002080acrosomal membrane IEA--
    GO:0005739mitochondrion IEA--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----

    BSG for ontologies           About GeneDecksing



    BSG Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of BSG
    R&D Systems Antibodies for BSG (EMMPRIN/CD147, TRA-1-85/CD147)
    Cell Signaling Technology (CST) Antibodies for BSG 
    OriGene Antibodies for BSG
    OriGene Custom Antibody Services for BSG
    GenScript Custom Superior Antibodies Services for BSG
    Novus Biologicals BSG Antibodies
    Abcam antibodies for BSG
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for BSG
    LSBio Antibodies in human, mouse, rat for BSG 

    Assay Products for BSG: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for BSG
    R&D Systems ELISAs for BSG (EMMPRIN/CD147)         (see all)
    GenScript Custom Assay Services for BSG
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    bloodgroup: Blood group antigens
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    5/6 InterPro protein domains (see all 6):
     IPR003598 Ig_sub2
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry P35613

    ProtoNet protein and cluster: P35613

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB003599 Immunoglobulin subtype


    UniProtKB/Swiss-Prot: BASI_HUMAN, P35613
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    BSG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BASI_HUMAN, P35613
    Function: Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor
    progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target
    monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and
    neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic
    processes (By similarity)
    Induction: Enriched on the surface of tumor cells. Up-regulated in gliomas. Its expression levels correlate with
    malignant potential of the tumor

         Genatlas biochemistry entry for BSG:
    basigin,widely expressed,involved in cell recognition,broadly expressed on hematopoietic cells stimulating nearly
    fibroblasts to synthesize matrix metalloproteinases,member of the Ig superfamily

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0005537mannose binding IEA--
         
    BSG for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Bsg):
     growth/size  immune system  liver/biliary system  mortality/aging  reproductive system 
     respiratory system 

    BSG for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Bsgtm1Tmu for BSG

       inGenious Targeting Laboratory - Custom generated mouse model solutions for BSG 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BSG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BSG 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BSG 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BSG
    1 QIAGEN miScript miRNA Assays for microRNA that regulate BSG:
    hsa-miR-1324
    SwitchGear 3'UTR luciferase reporter plasmidBSG 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene RNAi products in human, mouse, rat for BSG
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of BSG

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for BSG (see all 21)
    OriGene ORF clones in mouse, rat for BSG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): BSG (NM_198589)
    Sino Biological Human cDNA Clone for BSG
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BSG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BSG
    Sirion Biotech Customized lentivirus for stable overexpression of BSG 
                         Customized lentivirus expression plasmids for stable overexpression of BSG 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for BSG
    Search LifeMap BioReagents cell lines for BSG
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BSG


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BSG About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Pyruvate metabolism
    Pyruvate metabolism0.60
    Pyruvate metabolism and Citric Acid (TCA) cycle0.49
    2Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport0.72
    3Matrix Metalloproteinases
    Matrix Metalloproteinases0.68
    4Signaling by GPCR
    Signal Transduction0.55
    5Platelet activation, signaling and aggregation
    Hemostasis0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for BSG
        Adhesion

    2 BioSystems Pathways for BSG
        Matrix Metalloproteinases
    Syndecan-1-mediated signaling events


    5/9        Reactome Pathways for BSG (see all 9)
        Pyruvate metabolism and Citric Acid (TCA) cycle
    Hemostasis
    Pyruvate metabolism
    Integrin cell surface interactions
    Signal Transduction



    BSG for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BSG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/41 Interacting proteins for BSG (P356132, 3 ENSP000003337694) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDLIM7Q9NR122, 3, ENSP000003480994MINT-67881 I2D: score=5 STRING: ENSP00000348099
    CAV1Q031353, ENSP000003391914I2D: score=2 STRING: ENSP00000339191
    MMP1P039563, ENSP000003227884I2D: score=2 STRING: ENSP00000322788
    PPIAP629373, ENSP000004194254I2D: score=2 STRING: ENSP00000419425
    RFXANKO145933, ENSP000003050714I2D: score=2 STRING: ENSP00000305071
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006090pyruvate metabolic process TAS--
    GO:0007166cell surface receptor signaling pathway TAS9767135
    GO:0007566embryo implantation IEA--
    GO:0007596blood coagulation TAS--
    GO:0042475odontogenesis of dentin-containing tooth IEA--

    BSG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BSG for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BSG (BASI)

    10/27 Novoseek inferred chemical compound relationships for BSG gene (see all 27)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prinomastat 73.3 2 11726397 (1)
    gw9662 45.7 1 17007354 (1)
    vegf 39 53 17633444 (7), 19837976 (5), 15833850 (5), 16778084 (4) (see all 16)
    lactate 35.1 28 18761711 (3), 18778892 (2), 10921872 (2), 16434551 (2) (see all 15)
    sb 203580 29 1 9877171 (1)
    resveratrol 23.5 20 17007354 (7), 18647594 (6), 17055343 (5), 19561311 (1)
    heparan sulfate 23.2 4 17267519 (2), 14557624 (1), 17540735 (1)
    pioglitazone 20.4 5 17007354 (2), 17055343 (2), 16860414 (1)
    cyclosporin a 18.7 11 11353871 (3), 15946952 (2), 15671024 (1), 15732868 (1) (see all 5)
    cytochalasin b 17.7 2 11402500 (1)

    Search CenterWatch for drugs/clinical trials and news about BSG / BASI

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BSG gene (4 alternative transcripts): 
    NM_001728.3  NM_198589.2  NM_198590.2  NM_198591.2  

    Unigene Cluster for BSG:

    Basigin (Ok blood group)
    Hs.501293  [show with all ESTs]
    Unigene Representative Sequence: NM_001728
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000346916(uc002loy.3) ENST00000545507(uc021ulx.1) ENST00000333511(uc002loz.3 uc002lpa.3)
    ENST00000576925 ENST00000573216 ENST00000353555 ENST00000590218 ENST00000572899
    ENST00000573784 ENST00000574970 ENST00000576984 ENST00000571735(uc002lpc.3)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BSG
    1 QIAGEN miScript miRNA Assays for microRNA that regulate BSG:
    hsa-miR-1324
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    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BSG

    Additional mRNA sequence: 

    AB072923.1 AB085790.1 AB091680.1 AF548371.1 AK296858.1 AK297880.1 AK302231.1 AY358113.1 
    BC009040.2 D45131.1 GU557064.1 GU557065.1 L10240.1 L20471.1 M87879.1 X64364.1 

    24/64 DOTS entries (see all 64):

    DT.91668770  DT.453436  DT.121413366  DT.100888619  DT.100759067  DT.100888658  DT.121413196  DT.95301640 
    DT.100888653  DT.91804848  DT.100888660  DT.91642062  DT.100700252  DT.95161666  DT.121413247  DT.100888564 
    DT.100888620  DT.102843970  DT.100888633  DT.100888612  DT.100888566  DT.97861008  DT.95161635  DT.100888568 

    24/1946 AceView cDNA sequences (see all 1946):

    BG768281 AA774306 AI583685 BP336482 BM048144 BU158178 BP360576 AJ705916 
    BQ939999 BM849799 CA444147 CR603442 BX425334 BP369566 BM916929 CB156590 
    BU164027 AA781032 BP340484 BU839155 BU527227 CB267575 CR601862 CB120677 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for BSG (see all 13)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b ·
    SP1:                                      -           -     -                                   -                                                               
    SP2:                                      -     -     -     -                                   -                                                               
    SP3:                                      -     -     -     -                                   -                                                               
    SP4:                                                                                            -                                                               
    SP5:              -     -     -     -     -     -     -     -                                   -                                                               

    ExUns: 11c
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for BSG

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BSG expression in normal human tissues (normalized intensities)      BSG embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCGGGTGGG
    BSG Expression
    About this image


    BSG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Blood Brain Barrier (Nervous System)
             Endothelial Cells Blood Brain Barrier
     
     Endothelium (Cardiovascular System)
             Endothelial Cells Blood Brain Barrier
     
     Gonad (Reproductive System)
             Fetal Gonadal Stromal Cell
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Eye (Sensory Organs)
             Limbal epithelial stem cells

    See BSG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BSG

    SOURCE GeneReport for Unigene cluster: Hs.501293

    UniProtKB/Swiss-Prot: BASI_HUMAN, P35613
    Tissue specificity: Present only in vascular endothelium in non-neoplastic regions of the brain, whereas it is
    present in tumor cells but not in proliferating blood vessels in malignant gliomas

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for BSG gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bsg1 , 5 basigin1, 5 72.47(n)1
    65.71(a)1
      10 (39.72 cM)5
    122151  NM_009768.21  NP_033898.11 
     797044915 
    chicken
    (Gallus gallus)
    Aves BSG1 basigin (Ok blood group) 62.73(n)
    54.16(a)
      770363  NM_001198990.1  NP_001185919.1 
    lizard
    (Anolis carolinensis)
    Reptilia BSG6
    Uncharacterized protein
    64(a)
    1 ↔ 1
    GL344297.1(45012-45362)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU906264.12   -- 75.29(n)    BU906264.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI562797.12   -- 76.72(n)    BI562797.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Bsg6
    Basigin
    11(a)
    1 → many
    2L(8083420-8116531)


    ENSEMBL Gene Tree for BSG (if available)
    TreeFam Gene Tree for BSG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BSG gene
    NPTN2  EMB2  
    3 SIMAP similar genes for BSG using alignment to 4 protein entries:     BASI_HUMAN (see all proteins):
    hEMMPRIN    NPTN    DKFZp566H1924

    BSG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1955 SNPs in BSG are shown (see all 1955)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1048946691,2
    Cpathogenic1580428(+) TCCCCA/GAGCCC 7 K E mis1 ut510--------
    VAR_0135744
    ----see VAR_0135742 E K mis40--------
    rs1379858951,2
    C--569308(+) TTCTT-/AATCTG 2 -- us2k10--------
    rs1432754601,2
    C--569324(+) TAAGTC/TTGTTT 2 -- us2k10--------
    rs1482509381,2
    C--569357(+) GGCGCA/GGTGGC 2 -- us2k10--------
    rs621326231,2
    C--569500(+) CGGGCA/GCCTGT 2 -- us2k13Minor allele frequency- G:0.17NA 6
    rs1507708421,2
    --569629(+) CTCCAA/CAAAAA 2 -- us2k10--------
    rs1174564401,2
    C,F--569654(+) TCATGT/CTTCCT 2 -- us2k11Minor allele frequency- C:0.07NA 120
    rs104084081,2
    C,H--569721(+) tccttT/Gtaatt 2 -- us2k113Minor allele frequency- G:0.06NA WA CSA EA 376
    rs1394528701,2
    --569738(+) TCTCCA/GAGATC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for BSG (571297 - 583493 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/43 variations for BSG (see all 43):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2717744CNV Deletion23290073
    nsv910175CNV Loss21882294
    dgv3528n71CNV Loss21882294
    dgv3515n71CNV Loss21882294
    dgv3527n71CNV Loss21882294
    dgv3498n71CNV Loss21882294
    nsv910193CNV Loss21882294
    nsv910211CNV Loss21882294
    nsv910109CNV Loss21882294
    nsv910173CNV Loss21882294


    Human Gene Mutation Database (HGMD): BSG

    Locus Specific Mutation Databases (LSDB): BSG
    Blood Group Antigen Gene Mutation Database (BGMUT) blood group system
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 109480   
    OMIM disorders: 111380  
    20/114 diseases for BSG (see all 114):    About MalaCards
    spinal cord astrocytoma    brain stem neoplasm    brain stem glioma    laryngitis
    brain glioma    chronic venous leg ulcers    epithelioid sarcoma    laryngeal squamous cell carcinoma
    endometriosis    anaplastic large cell lymphoma    leiomyoma    astrocytoma
    mucolipidosis    lymphangioleiomyomatosis    ovarian endometriosis    primary effusion lymphoma
    anaplastic astrocytoma    reactive arthritis    gingival overgrowth    bladder transitional cell carcinoma

    2 diseases from the University of Copenhagen DISEASES database for BSG:
    Brain stem glioma     Carcinoma

    BSG for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/71 Novoseek inferred disease relationships for BSG gene (see all 71)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 61.6 101 11992541 (5), 19541433 (5), 18223224 (3), 16004819 (3) (see all 45)
    tumors 58 444 15833850 (8), 16633062 (6), 19569245 (6), 14985463 (6) (see all 99)
    carcinoma 46.6 36 14983875 (3), 19956835 (3), 19286191 (3), 19105397 (2) (see all 23)
    cancer 46.4 150 20199151 (5), 11395366 (4), 19597352 (3), 20406987 (3) (see all 57)
    chronic periodontitis 44.6 3 15853964 (1), 18315429 (1), 19515022 (1)
    stromal tumors 43 1 15833850 (1)
    laryngeal squamous cell carcinoma 42 6 16176007 (5), 18431027 (1)
    atherosclerotic plaque 38.7 22 15823273 (5), 19758589 (2), 15319264 (1), 18647594 (1) (see all 9)
    breast cancer 31.2 39 16004819 (6), 17706116 (3), 18035727 (3), 9154157 (3) (see all 19)
    breast carcinoma 30.9 9 19176383 (2), 20021962 (1), 16443928 (1), 10355528 (1)

    Genetic Association Database (GAD): BSG
    Human Genome Epidemiology (HuGE) Navigator: BSG (4 documents)

    Export disorders for BSG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BSG gene, integrated from 9 sources (see all 557):
    (articles sorted by number of sources associating them with BSG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily. (PubMed id 7812975)1, 2, 3, 9 Biswas C....Nabeshima K. (1995)
    2. Basigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion. (PubMed id 12792908)1, 2, 9 Muramatsu T. and Miyauchi T. (2003)
    3. Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin, and chicken HT7 molecule. (PubMed id 1634773)1, 2, 9 Kasinrerk W....Stockinger H. (1992)
    4. Partial sequencing and characterization of the tumor cell-derived collagenase stimulatory factor. (PubMed id 1846736)1, 2, 9 Nabeshima K.... Biswas C. (1991)
    5. Characterization of the gene for human EMMPRIN, a tumor cell surface inducer of matrix metalloproteinases. (PubMed id 9767135)1, 2, 9 Guo H.... Gordon M.K. (1998)
    6. The basigin group of the immunoglobulin superfamily: complete conservation of a segment in and around transmembrane domains of human and mouse basigin and chicken HT7 antigen. (PubMed id 1783610)1, 2, 9 Miyauchi T.... Muramatsu T. (1991)
    7. Characterization of basigin isoforms and the inhibito ry function of basigin-3 in human hepatocellular carcinoma proliferation and in vasion. (PubMed id 21536654)1, 2 Liao C.G....Chen Z.N. (2011)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    9. Structure of the EMMPRIN N-terminal domain 1: dimerization via beta- strand swapping. (PubMed id 19768682)1, 2 Luo J.... Gilliland G.L. (2009)
    10. Crystal structure of HAb18G/CD147: implications for immunoglobulin superfamily homophilic adhesion. (PubMed id 18430721)1, 2 Yu X.-L.... Chen Z.-N. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 682 HGNC: 1116 AceView: BSG Ensembl:ENSG00000172270 euGenes: HUgn682
    ECgene: BSG H-InvDB: BSG

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BSG Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BSG Genetics and Cytogenetics in Oncology and Haematology
    dbRBC/BGMUThttp://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=ok
    SeattleSNPshttp://pga.gs.washington.edu/data/bsg/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BSG gene:
    Search GeneIP for patents involving BSG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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