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BRSK2 Gene

protein-coding   GIFtS: 59
GCID: GC11P001368

BR Serine/Threonine Kinase 2

(Previous name: chromsosome 11 open reading frame 7)
(Previous symbols: C11orf7, STK29)
  See BRSK2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
BR Serine/Threonine Kinase 21 2     BR Serine/Threonine-Protein Kinase 22 3
C11orf71 2 3     EC 2.7.11.13 8
STK291 2 3     SAD12 5
PEN11B2 3 5     Chromsosome 11 Open Reading Frame 71
Brain-Selective Kinase 22 3     Serine/Threonine Kinase 291
Brain-Specific Serine/Threonine-Protein Kinase 22 3     Protein Kinase SAD1B2
Serine/Threonine-Protein Kinase 292 3     Serine/Threonine-Protein Kinase BRSK22
Serine/Threonine-Protein Kinase SAD-A2 3     EC 2.7.11.263
SADA2 3     EC 2.7.118

External Ids:    HGNC: 114051   Entrez Gene: 90242   Ensembl: ENSG000001746727   OMIM: 6092365   UniProtKB: Q8IWQ33   

Export aliases for BRSK2 gene to outside databases

Previous GC identifer: GC11P001247


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for BRSK2 Gene:
BRSK2 (BR serine/threonine kinase 2) is a protein-coding gene. Diseases associated with BRSK2 include limbic encephalitis. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is BRSK1.

UniProtKB/Swiss-Prot: BRSK2_HUMAN, Q8IWQ3
Function: Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell
cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following
phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons,
probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and
'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic
neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the
mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in
response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated
at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin
secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic
response triggered by endoplasmatic reticulum (ER) stress

Gene Wiki entry for BRSK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BRSK2 gene promoter:
         NF-1   Sp1   Tal-1   E2F   E2F-1   SEF-1 (1)   E47   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBRSK2 promoter sequence
   Search Chromatin IP Primers for BRSK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BRSK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

BRSK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRSK2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P001368:  view genomic region     (about GC identifiers)

Start:
1,411,129 bp from pter      End:
1,483,919 bp from pter
Size:
72,791 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: BRSK2_HUMAN, Q8IWQ3 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase BRSK2  
Size: 736 amino acids; 81633 Da
Cofactor: Magnesium (By similarity)
Subunit: Interacts with FZR1, a regulatory subunit of the APC ubiquitin ligase complex. Interacts with COPS5.
Interacts with PAK1
Sequence caution: Sequence=AAD09654.1; Type=Erroneous termination; Positions=663; Note=Translated as Gly;
Sequence=AAD09654.1; Type=Frameshift; Positions=640; Sequence=AAH24291.1; Type=Erroneous initiation;
Note=Translation N-terminally extended;
Secondary accessions: O60843 O95099 Q5J5B4 Q6ZMQ4 Q8TB60
Alternative splicing: 5 isoforms:  Q8IWQ3-1   Q8IWQ3-2   Q8IWQ3-3   Q8IWQ3-4   Q8IWQ3-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BRSK2: NX_Q8IWQ3

Explore proteomics data for BRSK2 at MOPED

Post-translational modifications: 

  • Phosphorylated at Thr-174 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and
    CAB39. Not phosphorylated at Thr-174 by CaMKK2. In contrast, it is phosphorylated and activated by CaMKK1. May be
    inactivated via dephosphorylation of Thr-174 by PP2C. Phosphorylated at Thr-260 by PKA. Phosphorylation at
    Thr-260 by PKA was not observed in another study (PubMed:18339622), but this may reflect differences in the
    experimental approach. Phosphorylation at Thr-260 seems to play a role in the regulation of insulin secretion
    (PubMed:22669945)1
  • Polyubiquitinated by the APC complex in conjunction with FZR1, leading to its proteasomal degradation. Targeted
    for proteasomal degradation by interaction with COPS5. BRSK2 levels change during the cell cycle. BRSK2 levels
    are low at the G1/S boundary and gradually increase as cells progress into G2 phase. BRSK2 levels decrease
    rapidly at the end of mitosis1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for BRSK2 (Q8IWQ3) (see all 8)
     WSCGVIL  LKPENLL  RDLKPEN  ALDFCHS 


    See BRSK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001243556.1  NP_001243558.1  NP_001243559.1  NP_001269147.1  NP_003948.2  

    ENSEMBL proteins: 
     ENSP00000310697   ENSP00000433684   ENSP00000432000   ENSP00000431152   ENSP00000433370  
     ENSP00000434075   ENSP00000432672   ENSP00000433235   ENSP00000371614   ENSP00000432252  
     ENSP00000436474   ENSP00000310805   ENSP00000445168  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: BR serine/threonine kinase 2
    BRSK subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q8IWQ3

    ProtoNet protein and cluster: Q8IWQ3

    UniProtKB/Swiss-Prot: BRSK2_HUMAN, Q8IWQ3
    Domain: The KEN box motif is required for interaction with FZR1/CDH1 and essential for APC(CDH1)-mediated
    ubiquitination
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 UBA domain


    Find genes that share domains with BRSK2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BRSK2_HUMAN, Q8IWQ3
    Function: Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell
    cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following
    phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons,
    probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and
    'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic
    neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the
    mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in
    response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated
    at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin
    secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic
    response triggered by endoplasmatic reticulum (ER) stress
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Catalytic activity: ATP + [tau protein] = ADP + [tau protein] phosphate
    Enzyme regulation: Activated by phosphorylation on Thr-174 by STK11/LKB1

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112 EC 2.7.11.261

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA14976552
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA14976552
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding ----
         
    Find genes that share ontologies with BRSK2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for BRSK2:
     Decreased telomerase activity  Increased cell death HMECs cel 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Brsk2):
     behavior/neurological  cellular  integument  mortality/aging  nervous system 
     normal 

    Find genes that share phenotypes with BRSK2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for BRSK2: Brsk2tm1Lex Brsk2tm1Jrs

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BRSK2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BRSK2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BRSK2

    miRNA
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    miRTarBase miRNAs that target BRSK2:
    hsa-mir-26b-5p (MIRT029356)

    Block miRNA regulation of human, mouse, rat BRSK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BRSK2 (see all 14):
    hsa-miR-3163 hsa-miR-22 hsa-miR-125a-5p hsa-miR-561 hsa-miR-340 hsa-miR-646 hsa-miR-582-5p hsa-miR-144
    SwitchGear 3'UTR luciferase reporter plasmidBRSK2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BRSK2_HUMAN, Q8IWQ3: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, perinuclear
    region. Endoplasmic reticulum. Note=Detected at centrosomes during mitosis. Localizes to the endoplasmic
    reticulum in response to stress caused by tunicamycin
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    endoplasmic reticulum5
    cytosol3
    nucleus2
    extracellular1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0005813centrosome IDA--
    GO:0048471perinuclear region of cytoplasm IEA--

    Find genes that share ontologies with BRSK2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BRSK2 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    2Neuroscience
    Neuroscience
    3LKB1 signaling events
    LKB1 signaling events
    4Glucose / Energy Metabolism
    Glucose / Energy Metabolism


    Find genes that share SuperPaths with BRSK2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for BRSK2
        Sperm Motility

    3 Cell Signaling Technology (CST) Pathways for BRSK2
        Cell Cycle / Checkpoint Control
    Neuroscience
    Glucose / Energy Metabolism

    1 BioSystems Pathway for BRSK2
        LKB1 signaling events


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BRSK2
    Interactions:

        Search GeneGlobe Interaction Network for BRSK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BRSK2 (Q8IWQ33 ENSP000003106974) via UniProtKB, MINT, STRING, and/or I2D (see all 163)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC25CP303073, ENSP000003216564I2D: score=1 STRING: ENSP00000321656
    PRMT5O147443, ENSP000003191694I2D: score=1 STRING: ENSP00000319169
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    WEE1P302913, ENSP000004020844I2D: score=1 STRING: ENSP00000402084
    KBTBD7Q8WVZ93, ENSP000003687974I2D: score=3 STRING: ENSP00000368797
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle IMP--
    GO:0006468protein phosphorylation IDA14976552
    GO:0006887exocytosis IEA--
    GO:0007067mitosis IEA--
    GO:0007409axonogenesis ISS--

    Find genes that share ontologies with BRSK2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BRSK2

    3 HMDB Compounds for BRSK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BRSK2 gene (5 alternative transcripts): 
    NM_001256627.1  NM_001256629.1  NM_001256630.1  NM_001282218.1  NM_003957.3  

    Unigene Cluster for BRSK2:

    BR serine/threonine kinase 2
    Hs.170819  [show with all ESTs]
    Unigene Representative Sequence: NM_001256627
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308219(uc001ltj.3 uc001ltk.3 uc001ltl.3 uc009ycw.3)
    ENST00000529433(uc001lth.1) ENST00000528841(uc001lti.3) ENST00000531197
    ENST00000526678 ENST00000528596 ENST00000524702 ENST00000528710(uc010qwx.2)
    ENST00000382179(uc001ltm.3 uc001ltn.3) ENST00000529951 ENST00000531078
    ENST00000533606 ENST00000526768 ENST00000531932 ENST00000308230(uc009ycv.1)
    ENST00000544817
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    Additional mRNA sequence: 

    AF020089.1 AF533876.1 AF533877.1 AF533879.1 AF533880.1 AJ006701.1 AK074411.1 AK122851.1 
    AK123356.2 AK131534.1 AK297211.1 AK297306.1 AY166857.1 AY505125.1 BC017182.2 BC024291.1 
    NR_046331.1 NR_046332.1 

    11 DOTS entries:

    DT.75100522  DT.101983763  DT.101983764  DT.101983762  DT.91745919  DT.40266701  DT.91947049  DT.97773804 
    DT.91745918  DT.100748802  DT.95201063 

    Selected AceView cDNA sequences (see all 70):

    BX090836 BF940493 BM475434 BF940549 BF222739 AW135560 AK131534 BQ067850 
    NM_003957 BI825755 BG395625 AI889053 BU729162 BM677936 BE264379 BM702384 
    AF533878 BU738345 BI916891 AL538014 BG395884 AF533879 BM805756 AF533877 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BRSK2 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b · 19c · 19d
    SP1:                                                                                                        -           -     -                                 
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                        -           -     -                                 
    SP5:                                                                                                        -           -     -                                 


    ECgene alternative splicing isoforms for BRSK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BRSK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTCGTCTG
    BRSK2 Expression
    About this image

    BRSK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BRSK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.170819

    UniProtKB/Swiss-Prot: BRSK2_HUMAN, Q8IWQ3
    Tissue specificity: Detected in pancreas islets (at protein level)

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for BRSK2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Brsk21 , 5 BR serine/threonine kinase 21, 5 89.18(n)1
    98.33(a)1
      7 (87.43 cM)5
    757701  NM_001009930.31  NP_001009930.11 
     1419497515 
    chicken
    (Gallus gallus)
    Aves BRSK21 BR serine/threonine kinase 2 79.97(n)
    93.17(a)
      423098  NM_001199596.1  NP_001186525.1 
    lizard
    (Anolis carolinensis)
    Reptilia BRSK26
    BR serine/threonine kinase 2
    92(a)
    1 ↔ 1
    1(71248499-71497130)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia brsk21 BR serine/threonine kinase 2 75.21(n)
    86.06(a)
      100489211  XM_004913460.1  XP_004913517.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.280762 Transcribed sequence 81.9(n)    57086203 
    fruit fly
    (Drosophila melanogaster)
    Insecta sff1 sugar-free frosting 60.66(n)
    62.76(a)
      39732  NM_001274972.1  NP_001261901.1 
    worm
    (Caenorhabditis elegans)
    Secernentea sad-11 sad-1 57.02(n)
    64.64(a)
      181471  NM_001083292.1  NP_001076761.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KCC46
    GIN46
    (see all 3)
    Protein kinase of the bud neck involved in the sep...
    Protein kinase involved in bud growth and assembly...
    (see all 3)
    21(a)
    19(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    III(79162-82275) YCL024W
    IV(1462358-1465786) YDR507C
    soybean
    (Glycine max)
    eudicotyledons 467300922   -- 72.31(n)  


    ENSEMBL Gene Tree for BRSK2 (if available)
    TreeFam Gene Tree for BRSK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BRSK2 gene
    BRSK12  MARK12  SNRK2  SIK32  SIK22  MARK22  NIM1K2  SIK12  
    MARK42  MARK32  
    Selected SIMAP similar genes for BRSK2 using alignment to 7 protein entries:     BRSK2_HUMAN (see all proteins) (see all similar genes):
    BRSK1    MARK3    MARK4    MARK2    NUAK1    KIAA0999
    PRKAA1    PRKD1    DAPK3    DAPK1    PHKG2    CAMK1G
    PNCK    SIK3    STK17A    STK33    AURKB    KIN27

    Find genes that share paralogs with BRSK2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BRSK2 (see all 2046)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1483686991,2
    C--1409233(+) GCAAAC/TGGTCA 4 -- us2k10--------
    rs1876591701,2
    --1409283(+) CTGACG/TCTGCT 4 -- us2k10--------
    rs618676071,2
    C,F--1409313(+) GACCAT/CGGCAG 4 -- us2k14Minor allele frequency- C:0.04NA WA EA 244
    rs1415776451,2
    C--1409352(+) CCCTGA/CCCTCT 4 -- us2k10--------
    rs1173551681,2
    F--1409555(+) GAGTGC/TCCTCT 4 -- us2k11Minor allele frequency- T:0.02NA 120
    rs561183621,2
    C--1409736(+) TCCCCT/-TCCCC 4 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1131482001,2
    C--1409738(+) CCCCTC/TCCCAG 4 -- us2k10--------
    rs1462904201,2
    C--1409870(+) GCCCGC/GAGGGG 4 -- us2k10--------
    rs1910288971,2
    --1409895(+) GACCAC/TACACG 4 -- us2k10--------
    rs1137849551,2
    C,F--1409994(+) AATACC/GAGTGT 4 -- us2k12Minor allele frequency- G:0.04CSA WA 120

    HapMap Linkage Disequilibrium report for BRSK2 (1411129 - 1483919 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for BRSK2 (see all 55):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2743916CNV Deletion23290073
    esv1962941CNV Deletion18987734
    esv2743915CNV Deletion23290073
    esv2743937CNV Deletion23290073
    nsv820797CNV Deletion20802225
    dgv147e201CNV Deletion23290073
    esv2657570CNV Deletion23128226
    esv2743928CNV Deletion23290073
    esv2743934CNV Deletion23290073
    esv2743878CNV Deletion23290073

    Human Gene Mutation Database (HGMD): BRSK2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BRSK2
    DNA2.0 Custom Variant and Variant Library Synthesis for BRSK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609236    OMIM disorders: --

    1 disease for BRSK2:    
    About MalaCards
    limbic encephalitis


    Find genes that share disorders with BRSK2           About GenesLikeMe

    Genetic Association Database (GAD): BRSK2

    Export disorders for BRSK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BRSK2 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with BRSK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Repeat-directed isolation of a novel gene preferentially expressed from the maternal allele in human placenta. (PubMed id 9929968)1, 2, 3 Miura K.... Ishimaru T. (J. Hum. Genet. 1999)
    2. BRSK2 is regulated by ER stress in protein level and involved in ER stress-induced apoptosis. (PubMed id 22713462)1, 2 Wang Y.... Yu L. (Biochem. Biophys. Res. Commun. 2012)
    3. Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic beta-cells. (PubMed id 22798068)1, 2 Chen X.Y.... Yu L. (J. Biol. Chem. 2012)
    4. APC/C(Cdh1) targets brain-specific kinase 2 (BRSK2) for degradation via the ubiquitin-proteasome pathway. (PubMed id 23029325)1, 2 Li R.... Yu L. (PLoS ONE 2012)
    5. Jab1 interacts with brain-specific kinase 2 (BRSK2) and promotes its degradation in the ubiquitin-proteasome pathway. (PubMed id 22609399)1, 2 Zhou J.... Yu L. (Biochem. Biophys. Res. Commun. 2012)
    6. Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation. (PubMed id 18339622)1, 2 Bright N.J.... Thornton C. (J. Biol. Chem. 2008)
    7. SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release. (PubMed id 16630837)1, 2 Inoue E.... Takai Y. (Neuron 2006)
    8. BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260. (PubMed id 16870137)1, 2 Guo Z....Yu L. (Biochem. Biophys. Res. Commun. 2006)
    9. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. (PubMed id 14976552)1, 2 Lizcano J.M....Alessi D.R. (EMBO J. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9024 HGNC: 11405 AceView: STK29 Ensembl:ENSG00000174672 euGenes: HUgn9024
    ECgene: BRSK2 H-InvDB: BRSK2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BRSK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BRSK2 gene:
    Search GeneIP for patents involving BRSK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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