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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BRSK2 Gene

protein-coding   GIFtS: 57
GCID: GC11P001368

BR serine/threonine kinase 2

(Previous name: chromsosome 11 open reading frame 7 )
(Previous symbols: C11orf7, STK29)
 Explore 6 diseases affiliated with
BRSK2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for BRSK2    

Aliases
for BRSK2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
BR Serine/Threonine Kinase 21 2     EC 2.7.11.13 8
C11orf71 2 3     Chromsosome 11 Open Reading Frame 71
PEN11B1 2 3     SAD12
STK291 2 3     Protein Kinase SAD1B2
Brain-Selective Kinase 22 3     Serine/Threonine-Protein Kinase BRSK22
Brain-Specific Serine/Threonine-Protein Kinase 22 3     EC 2.7.11.263
Serine/Threonine-Protein Kinase 292 3     SADA3
Serine/Threonine-Protein Kinase SAD-A2 3     EC 2.7.118
BR Serine/Threonine-Protein Kinase 22 3     

External Ids:    HGNC: 114051   Entrez Gene: 90242   Ensembl: ENSG000001746727   OMIM: 6092365   UniProtKB: Q8IWQ33   

Export aliases for BRSK2 gene to outside databases

Previous GC identifer: GC11P001247


Summaries
for BRSK2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: BRSK2_HUMAN, Q8IWQ3
Function: Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle
progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and
activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating
phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron
polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1
activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of
mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via
phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion
(PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates
reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmatic
reticulum (ER) stress

Gene Wiki entry for BRSK2


Genomic Views
for BRSK2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BRSK2 gene promoter:
         NF-1   Sp1   Tal-1   E2F   E2F-1   SEF-1 (1)   E47   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BRSK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for BRSK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BRSK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

BRSK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRSK2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P001368:  view genomic region     (about GC identifiers)

Start:
 1,411,129 bp from pter      End:
 1,483,919 bp from pter
Size:
 72,791 bases      Orientation:
 plus strand

Proteins
for BRSK2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: BRSK2_HUMAN, Q8IWQ3 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase BRSK2  
Size: 736 amino acids; 81633 Da
Cofactor: Magnesium (By similarity)
Subunit: Interacts with FZR1, a regulatory subunit of the APC ubiquitin ligase complex. Interacts with COPS5. Interacts
with PAK1
Subcellular location: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, perinuclear region. Endoplasmic reticulum.
Note=Detected at centrosomes during mitosis. Localizes to the endoplasmic reticulum in response to stress caused by
tunicamycin
Sequence caution: Sequence=AAD09654.1; Type=Erroneous termination; Positions=663; Note=Translated as Gly;
Sequence=AAD09654.1; Type=Frameshift; Positions=640; Sequence=AAH24291.1; Type=Erroneous initiation; Note=Translation
N-terminally extended;
Secondary accessions: O60843 O95099 Q5J5B4 Q6ZMQ4 Q8TB60
Alternative splicing: 5 isoforms:  Q8IWQ3-1   Q8IWQ3-2   Q8IWQ3-3   Q8IWQ3-4   Q8IWQ3-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BRSK2: NX_Q8IWQ3

Post-translational modifications:

  • Phosphorylated at Thr-174 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.
    • Not phosphorylated at Thr-174 by CaMKK2. In contrast, it is phosphorylated and activated by CaMKK1. May be inactivated
    via dephosphorylation of Thr-174 by PP2C. Phosphorylated at Thr-260 by PKA. Phosphorylation at Thr-260 by PKA was not
    observed in another study (PubMed:18339622), but this may reflect differences in the experimental approach.
    Phosphorylation at Thr-260 seems to play a role in the regulation of insulin secretion (PubMed:22669945)1
  • Polyubiquitinated by the APC complex in conjunction with FZR1, leading to its proteasomal degradation. Targeted for
    • proteasomal degradation by interaction with COPS5. BRSK2 levels change during the cell cycle. BRSK2 levels are low at
    the G1/S boundary and gradually increase as cells progress into G2 phase. BRSK2 levels decrease rapidly at the end of
    mitosis1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8IWQ3

    • 4/8 DME Specific Peptides for BRSK2 (Q8IWQ3) (see all 8)
     WSCGVIL  LKPENLL  RDLKPEN  ALDFCHS 

    BRSK2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001243556.1  NP_001243558.1  NP_001243559.1  NP_003948.2  

    ENSEMBL proteins: 
     ENSP00000310697   ENSP00000433684   ENSP00000432000   ENSP00000431152   ENSP00000433370  
     ENSP00000434075   ENSP00000432672   ENSP00000433235   ENSP00000371614   ENSP00000432252  
     ENSP00000436474   ENSP00000310805   ENSP00000445168  

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    Uscn Proteins for BRSK2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0005813centrosome IDA--
    GO:0048471perinuclear region of cytoplasm IEA--


    BRSK2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for BRSK2

    Protein Domains /
    Families
    for BRSK2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    BRSK2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q8IWQ3

    ProtoNet protein and cluster: Q8IWQ3

    UniProtKB/Swiss-Prot: BRSK2_HUMAN, Q8IWQ3
    Domain: The KEN box motif is required for interaction with FZR1/CDH1 and essential for APC(CDH1)-mediated
    ubiquitination
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 UBA domain


    Function
    for BRSK2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: BRSK2_HUMAN, Q8IWQ3
    Function: Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle
    progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and
    activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating
    phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron
    polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1
    activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of
    mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via
    phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion
    (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates
    reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmatic
    reticulum (ER) stress
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Catalytic activity: ATP + [tau protein] = ADP + [tau protein] phosphate
    Enzyme regulation: Activated by phosphorylation on Thr-174 by STK11/LKB1

    Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112 EC 2.7.11.261

    miRNA
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    hsa-miR-3163 hsa-miR-22 hsa-miR-125a-5p hsa-miR-561 hsa-miR-340 hsa-miR-646 hsa-miR-582-5p hsa-miR-144
    SwitchGear 3'UTR luciferase reporter plasmid: BRSK2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA14976552
    GO:0004674protein serine/threonine kinase activity IDA14976552
    GO:0005515protein binding ----
    GO:0005524ATP binding IDA14976552
    GO:0016301kinase activity ----


    BRSK2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for BRSK2:
     Decreased telomerase activity  Increased cell death HMECs cel 

    Animal Models:
         Mouse knock-outs for BRSK2: Brsk2tm1Lex Brsk2tm1Jrs
         6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Brsk2):
     behavior/neurological  cellular  integument  mortality/aging  nervous system 
     normal 

    BRSK2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for BRSK2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Neuroscience
    		Neuroscience1.00
    2Cell Cycle / Checkpoint Control
    		Cell Cycle / Checkpoint Control1.00
    3LKB1 signaling events
    		LKB1 signaling events1.00
    4Glucose / Energy Metabolism
    		Glucose / Energy Metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for BRSK2
        Cell Cycle / Checkpoint Control
    Neuroscience
    Glucose / Energy Metabolism

    1 BioSystems Pathway for BRSK2 
        LKB1 signaling events



    BRSK2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BRSK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/13 Interacting proteins for BRSK2 (Q8IWQ33 ENSP000003106974) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KBTBD7Q8WVZ93, ENSP000003687974I2D: score=3 STRING: ENSP00000368797
    CDC25CP303073, ENSP000003216564I2D: score=1 STRING: ENSP00000321656
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    WEE1P302913, ENSP000004020844I2D: score=1 STRING: ENSP00000402084
    PRKAA1Q131313, ENSP000003461484I2D: score=1 STRING: ENSP00000346148
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle IMP--
    GO:0006468protein phosphorylation IDA14976552
    GO:0006887exocytosis IEA--
    GO:0007067mitosis IEA--
    GO:0007409axonogenesis ISS--


    BRSK2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for BRSK2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for BRSK2

    3 HMDB Compounds for BRSK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Search CenterWatch for drugs/clinical trials and news about BRSK2 

    Transcripts
    for BRSK2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for BRSK2 gene (4 alternative transcripts): 
    NM_001256627.1  NM_001256629.1  NM_001256630.1  NM_003957.3  

    Unigene Cluster for BRSK2:

    BR serine/threonine kinase 2
    Hs.170819  [show with all ESTs]
    Unigene Representative Sequence: NM_001256627
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308219(uc001ltj.3 uc001ltk.3 uc001ltl.3 uc009ycw.3)
    ENST00000529433(uc001lth.1) ENST00000528841(uc001lti.3) ENST00000531197
    ENST00000526678 ENST00000528596 ENST00000524702 ENST00000528710(uc010qwx.2)
    ENST00000382179(uc001ltm.3 uc001ltn.3) ENST00000529951 ENST00000531078
    ENST00000533606 ENST00000526768 ENST00000531932 ENST00000308230(uc009ycv.1)
    ENST00000544817

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    hsa-miR-3163 hsa-miR-22 hsa-miR-125a-5p hsa-miR-561 hsa-miR-340 hsa-miR-646 hsa-miR-582-5p hsa-miR-144
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    Inhib. RNA
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    Additional cDNA sequence: 

    AF020089.1 AF533876.1 AF533877.1 AF533879.1 AF533880.1 AJ006701.1 AK074411.1 AK122851.1 
    AK123356.2 AK131534.1 AK297211.1 AK297306.1 AY166857.1 AY505125.1 BC017182.2 BC024291.1 
    NR_046331.1 NR_046332.1 

    11 DOTS entries:

    DT.75100522  DT.101983763  DT.101983764  DT.101983762  DT.91745919  DT.40266701  DT.91947049  DT.97773804 
    DT.91745918  DT.100748802  DT.95201063 

    24/70 AceView cDNA sequences (see all 70):

    AW135560 BF940549 BM475434 BF222739 BX090836 BF940493 AK131534 BU729691 
    BQ188808 BI825755 AK123356 BM719852 AF533878 BU729162 BG122500 AW590719 
    BG395884 BE550940 BM805756 AF533876 BG395625 BM677936 NM_003957 BC024291 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for BRSK2 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b · 19c · 19d
    SP1:                                                                                                        -           -     -                                 
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                        -           -     -                                 
    SP5:                                                                                                        -           -     -                                 


    ECgene alternative splicing isoforms for BRSK2

    Expression
    for BRSK2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BRSK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGTCGTCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    BRSK2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See BRSK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BRSK2

    SOURCE GeneReport for Unigene cluster: Hs.170819

    UniProtKB/Swiss-Prot: BRSK2_HUMAN, Q8IWQ3
    Tissue specificity: Detected in pancreas islets (at protein level)

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    In Situ
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    Orthologs
    for BRSK2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for BRSK2 gene from 7/24 species (see all 24)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves BRSK21 BR serine/threonine kinase 2 81.24(n)
    97.46(a)    		   423098  NM_001199596.1  NP_001186525.1 
    lizard
    (Anolis carolinensis)    		 Reptilia BRSK26
    		 --
    		 86(a)
    		 1 ↔ 1
    		 1(71284766-71406534)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.280762 Transcribed sequence 81.9(n)    57086203 
    fruit fly
    (Drosophila melanogaster)    		 Insecta sff6
    		 sugar-free frosting
    		 49(a)
    		 1 → many
    		 3L(15893256-15917961)
    worm
    (Caenorhabditis elegans)    		 Secernentea sad-16
    		 Serine/threonine kinase SAD-1
    		 41(a)
    		 1 → many
    		 X(13487802-13500580)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons CIPK156
    AT5G213266
    (see all 36)    		 CBL-interacting serine/threonine-protein kinase 15...
    CBL-interacting serine/threonine-protein kinase 26...
    (see all 36)    		 30(a)
    30(a)
    (see all 36)    		 many ↔ many
    many ↔ many
    (see all 36)    		 5(309434-312097)
    5(7217340-7222007)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 44)    		 serine/threonine-protein kinase SAPK4, putative
    CAMK_KIN1/SNF1/Nim1_like.35 - CAMK includes calciu...
    (see all 44)    		 33(a)
    31(a)
    (see all 44)    		 many ↔ many
    many ↔ many
    (see all 44)    		 5(21166865-21168471)
    9(15026139-15027688)


    ENSEMBL Gene Tree for BRSK2 (if available)
    TreeFam Gene Tree for BRSK2 (if available) 

    Paralogs
    for BRSK2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BRSK2 gene
    BRSK12  NUAK12  MARK12  SIK32  SNRK2  SIK22  NUAK22  MARK22  
    NIM12  SIK12  MARK42  MARK32  
    18/114 SIMAP similar genes for BRSK2 using alignment to 7 protein entries:     BRSK2_HUMAN (see all proteins) (see all similar genes):
    BRSK1    MARK3    MARK4    NUAK1    KIAA0999    MARK2
    PRKAA1    PRKD1    DAPK1    PHKG2    CAMK1G    PSKH1
    PNCK    MELK    STK17A    STK33    KIN27    CHEK1

    BRSK2 for paralogs           About GeneDecksing



    Genomic Variants
    for BRSK2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1472 NCBI SNPs in BRSK2 are shown (see all 1472)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1483686991,2
    		--1409233(+) GCAAAC/TGGTCA 4 -- us2k10--------
    rs1876591701,2
    		--1409283(+) CTGACG/TCTGCT 4 -- us2k10--------
    rs618676071,2
    		C,F,--1409313(+) GACCAT/CGNNNN 4 -- us2k14Minor allele frequency- C:0.04NA WA EA 244
    rs1415776451,2
    		--1409352(+) CCCTGA/CCCTCT 4 -- us2k10--------
    rs1173551681,2
    		F,--1409555(+) GAGTGC/TCCTCT 4 -- us2k11Minor allele frequency- T:0.02NA 120
    rs561183621,2
    		C,--1409736(+) TCCCC-/TTCCCC 4 -- us2k10--------
    rs710257281,2
    		C--1409737(+) CCCCTT/-CCCCA 4 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1131482001,2
    		C--1409738(+) NNNNTC/TCCCAG 4 -- us2k10--------
    rs1462904201,2
    		--1409870(+) GCCCGC/GAGGGG 4 -- us2k10--------
    rs1910288971,2
    		--1409895(+) GACCAC/TACACG 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for BRSK2 (1411129 - 1483919 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 10 variations for BRSK2
         6 CNVs: 4729 4728 71228 23402 34926 71227
         4 Indels: 71226 24676 44846 24677
    Human Gene Mutation Database (HGMD): BRSK2

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    Disorders / Diseases
    for BRSK2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    BRSK2 for disorders           About GeneDecksing

    OMIM gene information: 609236    OMIM disorders: --

    6 diseases for BRSK2:    About MalaCards
    limbic encephalitis    encephalitis    adenocarcinoma    pancreatitis
    malaria    neuronitis


    Export disorders for BRSK2 gene to outside databases

    Publications
    for BRSK2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BRSK2 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with BRSK2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Repeat-directed isolation of a novel gene preferentially expressed from the maternal allele in human placenta. (PubMed id 9929968)1, 2, 3 Miura K.... Ishimaru T. (1999)
    2. BRSK2 is regulated by ER stress in protein level and involved in ER stress-induced apoptosis. (PubMed id 22713462)1, 2 Wang Y.... Yu L. (2012)
    3. Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic beta-cells. (PubMed id 22798068)1, 2 Chen X.Y.... Yu L. (2012)
    4. APC/C(Cdh1) targets brain-specific kinase 2 (BRSK2) for degradation via the ubiquitin-proteasome pathway. (PubMed id 23029325)1, 2 Li R.... Yu L. (2012)
    5. Jab1 interacts with brain-specific kinase 2 (BRSK2) an d promotes its degradation in the ubiquitin-proteasome pathway. (PubMed id 22609399)1, 2 Zhou J....Yu L. (2012)
    6. Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation. (PubMed id 18339622)1, 2 Bright N.J....Thornton C. (2008)
    7. BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260. (PubMed id 16870137)1, 2 Guo Z....Yu L. (2006)
    8. SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release. (PubMed id 16630837)1, 2 Inoue E....Takai Y. (2006)
    9. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. (PubMed id 14976552)1, 2 Lizcano J.M....Alessi D.R. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for BRSK2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing BRSK2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9024 HGNC: 11405 AceView: STK29 Ensembl:ENSG00000174672 euGenes: HUgn9024
    ECgene: BRSK2 H-InvDB: BRSK2

    Other Databases showing BRSK2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing BRSK2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BRSK2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for BRSK2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for BRSK2 gene:
    Search GeneIP for patents involving BRSK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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