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Aliases for BRSK1 Gene

Aliases for BRSK1 Gene

  • BR Serine/Threonine Kinase 1 2 3
  • Brain-Specific Serine/Threonine-Protein Kinase 1 3 4
  • Synapses Of Amphids Defective Homolog 1 3 4
  • Serine/Threonine-Protein Kinase SAD-B 3 4
  • BR Serine/Threonine-Protein Kinase 1 3 4
  • Brain-Selective Kinase 1 3 4
  • SAD1 Homolog 3 4
  • EC 2.7.11.1 4 64
  • KIAA1811 4 6
  • HSAD1 3 4
  • Serine/Threonine-Protein Kinase BRSK1 3
  • SadB Kinase Short Isoform 3
  • Protein Kinase SAD1A 3
  • EC 2.7.11.26 4
  • SAD1 Kinase 3
  • EC 2.7.11 64
  • SAD1 4
  • SADB 4

External Ids for BRSK1 Gene

Summaries for BRSK1 Gene

GeneCards Summary for BRSK1 Gene

BRSK1 (BR Serine/Threonine Kinase 1) is a Protein Coding gene. Among its related pathways are Cell Cycle / Checkpoint Control and Glucose / Energy Metabolism. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is MARK4.

UniProtKB/Swiss-Prot for BRSK1 Gene

  • Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at Thr-529 and Ser-579. Also regulates neuron polarization by mediating phosphorylation of WEE1 at Ser-642 in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at Ser-131, leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.

Gene Wiki entry for BRSK1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRSK1 Gene

Genomics for BRSK1 Gene

Genomic Location for BRSK1 Gene

Start:
55,282,072 bp from pter
End:
55,312,562 bp from pter
Size:
30,491 bases
Orientation:
Plus strand

Genomic View for BRSK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BRSK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRSK1 Gene

Regulatory Elements for BRSK1 Gene

Proteins for BRSK1 Gene

  • Protein details for BRSK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDC3-BRSK1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase BRSK1
    Protein Accession:
    Q8TDC3
    Secondary Accessions:
    • F1DG44
    • Q5J5B5
    • Q8NDD0
    • Q8NDR4
    • Q8TDC2
    • Q96AV4
    • Q96JL4

    Protein attributes for BRSK1 Gene

    Size:
    778 amino acids
    Molecular mass:
    85087 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH16681.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for BRSK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BRSK1 Gene

Proteomics data for BRSK1 Gene at MOPED

Selected DME Specific Peptides for BRSK1 Gene

Post-translational modifications for BRSK1 Gene

  • Phosphorylated at Thr-189 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Not phosphorylated at Thr-189 by CaMKK2. In contrast, it is phosphorylated and activated by CaMKK1. May be inactivated via dephosphorylation of Thr-189 by PP2C.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BRSK1 Gene

Domains for BRSK1 Gene

Gene Families for BRSK1 Gene

UniProtKB/Swiss-Prot:

BRSK1_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • Q8TDC3
  • Contains 1 UBA domain.:
    • Q8TDC3
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.:
    • Q8TDC3
genes like me logo Genes that share domains with BRSK1: view

Function for BRSK1 Gene

Molecular function for BRSK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot CatalyticActivity: ATP + [tau protein] = ADP + [tau protein] phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by phosphorylation on Thr-189 by STK11/LKB1.
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at Thr-529 and Ser-579. Also regulates neuron polarization by mediating phosphorylation of WEE1 at Ser-642 in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at Ser-131, leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.

Enzyme Numbers (IUBMB) for BRSK1 Gene

Gene Ontology (GO) - Molecular Function for BRSK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 14976552
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 15150265
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with BRSK1: view
genes like me logo Genes that share phenotypes with BRSK1: view

Animal Models for BRSK1 Gene

MGI Knock Outs for BRSK1:

miRNA for BRSK1 Gene

miRTarBase miRNAs that target BRSK1

No data available for Transcription Factor Targeting and HOMER Transcription for BRSK1 Gene

Localization for BRSK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRSK1 Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, synapse. Note=Localizes to synaptic vesicles in neurons (By similarity). Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS-induced DNA damage. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BRSK1 Gene COMPARTMENTS Subcellular localization image for BRSK1 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
plasma membrane 4
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BRSK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15150265
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 15150265
GO:0005813 centrosome ISS --
GO:0005886 plasma membrane --
genes like me logo Genes that share ontologies with BRSK1: view

Pathways for BRSK1 Gene

genes like me logo Genes that share pathways with BRSK1: view

Pathways by source for BRSK1 Gene

3 Cell Signaling Technology pathways for BRSK1 Gene
1 BioSystems pathway for BRSK1 Gene

Gene Ontology (GO) - Biological Process for BRSK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IBA --
GO:0006468 protein phosphorylation IDA 15150265
GO:0006974 cellular response to DNA damage stimulus IDA 15150265
GO:0007269 neurotransmitter secretion ISS --
GO:0007409 axonogenesis ISS --
genes like me logo Genes that share ontologies with BRSK1: view

Compounds for BRSK1 Gene

(4) HMDB Compounds for BRSK1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4
Sumatriptan
  • Imigran
103628-46-2
genes like me logo Genes that share compounds with BRSK1: view

Transcripts for BRSK1 Gene

Unigene Clusters for BRSK1 Gene

BR serine/threonine kinase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BRSK1 Gene

No ASD Table

Relevant External Links for BRSK1 Gene

GeneLoc Exon Structure for
BRSK1
ECgene alternative splicing isoforms for
BRSK1

Expression for BRSK1 Gene

mRNA expression in normal human tissues for BRSK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BRSK1 Gene

This gene is overexpressed in Brain - Cortex (6.3), Brain - Frontal Cortex (BA9) (5.0), Brain - Anterior cingulate cortex (BA24) (5.0), and Brain - Hippocampus (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BRSK1 Gene

SOURCE GeneReport for Unigene cluster for BRSK1 Gene Hs.182081

mRNA Expression by UniProt/SwissProt for BRSK1 Gene

Q8TDC3-BRSK1_HUMAN
Tissue specificity: Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle.
genes like me logo Genes that share expressions with BRSK1: view

Orthologs for BRSK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BRSK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BRSK1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BRSK1 36
  • 92.77 (n)
  • 99.07 (a)
BRSK1 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BRSK1 36
  • 92.84 (n)
  • 98.84 (a)
BRSK1 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Brsk1 36
  • 91.17 (n)
  • 99.1 (a)
Brsk1 16
Brsk1 37
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BRSK1 37
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Brsk1 36
  • 90.96 (n)
  • 98.97 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 25 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia BRSK1 37
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia brsk1 36
  • 71.52 (n)
  • 84 (a)
zebrafish
(Danio rerio)
Actinopterygii BRSK1 (1 of 2) 37
  • 67 (a)
OneToMany
BRSK1 (2 of 2) 37
  • 67 (a)
OneToMany
LOC558390 36
  • 70.81 (n)
  • 81.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta sff 37
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sad-1 37
  • 42 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GIN4 37
  • 19 (a)
ManyToMany
GIN4 39
HSL1 37
  • 16 (a)
ManyToMany
KCC4 37
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 54 (a)
OneToMany
Species with no ortholog for BRSK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BRSK1 Gene

ENSEMBL:
Gene Tree for BRSK1 (if available)
TreeFam:
Gene Tree for BRSK1 (if available)

Paralogs for BRSK1 Gene

Paralogs for BRSK1 Gene

genes like me logo Genes that share paralogs with BRSK1: view

Variants for BRSK1 Gene

Sequence variations from dbSNP and Humsavar for BRSK1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1113615 -- 55,309,490(+) GGGAA(A/G)TCCAA intron-variant
rs1172816 -- 55,294,662(+) acttc(C/T)agata intron-variant
rs1172817 -- 55,295,901(+) gaggt(G/T)gagtt intron-variant
rs1172818 -- 55,296,263(+) CTTCC(C/T)TTCTG intron-variant
rs1172819 -- 55,301,880(+) AGGGC(A/G)CAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BRSK1 Gene

Variant ID Type Subtype PubMed ID
dgv4016n71 CNV Loss 21882294
nsv912457 CNV Loss 21882294
nsv912458 CNV Loss 21882294
nsv912459 CNV Loss 21882294
nsv912460 CNV Loss 21882294
esv1551083 CNV Insertion 17803354

Relevant External Links for BRSK1 Gene

HapMap Linkage Disequilibrium report
BRSK1
Human Gene Mutation Database (HGMD)
BRSK1

Disorders for BRSK1 Gene

Relevant External Links for BRSK1

Genetic Association Database (GAD)
BRSK1
Human Genome Epidemiology (HuGE) Navigator
BRSK1
genes like me logo Genes that share disorders with BRSK1: view

No data available for UniProtKB/Swiss-Prot for BRSK1 Gene

Publications for BRSK1 Gene

  1. Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function. (PMID: 15150265) Lu R. … Nakanishi M. (J. Biol. Chem. 2004) 3 4 23
  2. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. (PMID: 14976552) Lizcano J.M. … Alessi D.R. (EMBO J. 2004) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 3 4
  5. SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release. (PMID: 16630837) Inoue E. … Takai Y. (Neuron 2006) 3 4

Products for BRSK1 Gene

  • Addgene plasmids for BRSK1

Sources for BRSK1 Gene

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