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Aliases for BRSK1 Gene

Aliases for BRSK1 Gene

  • BR Serine/Threonine Kinase 1 2 3 5
  • Brain-Specific Serine/Threonine-Protein Kinase 1 3 4
  • Synapses Of Amphids Defective Homolog 1 3 4
  • Serine/Threonine-Protein Kinase SAD-B 3 4
  • BR Serine/Threonine-Protein Kinase 1 3 4
  • Brain-Selective Kinase 1 3 4
  • SAD1 Homolog 3 4
  • EC 2.7.11.1 4 63
  • HSAD1 3 4
  • SadB Kinase Short Isoform 3
  • Protein Kinase SAD1A 3
  • EC 2.7.11.26 4
  • SAD1 Kinase 3
  • EC 2.7.11 63
  • KIAA1811 4
  • SAD1 4
  • SADB 4

External Ids for BRSK1 Gene

Previous GeneCards Identifiers for BRSK1 Gene

  • GC19P060383
  • GC19P060488
  • GC19P055795
  • GC19P052118

Summaries for BRSK1 Gene

GeneCards Summary for BRSK1 Gene

BRSK1 (BR Serine/Threonine Kinase 1) is a Protein Coding gene. Among its related pathways are DNA Damage and Glucose / Energy Metabolism. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is BRSK2.

UniProtKB/Swiss-Prot for BRSK1 Gene

  • Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at Thr-529 and Ser-579. Also regulates neuron polarization by mediating phosphorylation of WEE1 at Ser-642 in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at Ser-131, leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.

Gene Wiki entry for BRSK1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRSK1 Gene

Genomics for BRSK1 Gene

Regulatory Elements for BRSK1 Gene

Enhancers for BRSK1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BRSK1 on UCSC Golden Path with GeneCards custom track

Promoters for BRSK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BRSK1 on UCSC Golden Path with GeneCards custom track

Genomic Location for BRSK1 Gene

Chromosome:
19
Start:
55,282,072 bp from pter
End:
55,312,562 bp from pter
Size:
30,491 bases
Orientation:
Plus strand

Genomic View for BRSK1 Gene

Genes around BRSK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRSK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRSK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRSK1 Gene

Proteins for BRSK1 Gene

  • Protein details for BRSK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDC3-BRSK1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase BRSK1
    Protein Accession:
    Q8TDC3
    Secondary Accessions:
    • F1DG44
    • Q5J5B5
    • Q8NDD0
    • Q8NDR4
    • Q8TDC2
    • Q96AV4
    • Q96JL4

    Protein attributes for BRSK1 Gene

    Size:
    778 amino acids
    Molecular mass:
    85087 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH16681.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for BRSK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BRSK1 Gene

Proteomics data for BRSK1 Gene at MOPED

Selected DME Specific Peptides for BRSK1 Gene

Post-translational modifications for BRSK1 Gene

  • Phosphorylated at Thr-189 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Not phosphorylated at Thr-189 by CaMKK2. In contrast, it is phosphorylated and activated by CaMKK1. May be inactivated via dephosphorylation of Thr-189 by PP2C.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BRSK1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for BRSK1 (BRSK1)

Domains & Families for BRSK1 Gene

Gene Families for BRSK1 Gene

Suggested Antigen Peptide Sequences for BRSK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TDC3

UniProtKB/Swiss-Prot:

BRSK1_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Domain:
  • Contains 1 protein kinase domain.
  • Contains 1 UBA domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
genes like me logo Genes that share domains with BRSK1: view

Function for BRSK1 Gene

Molecular function for BRSK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [tau protein] = ADP + [tau protein] phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on Thr-189 by STK11/LKB1.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at Thr-529 and Ser-579. Also regulates neuron polarization by mediating phosphorylation of WEE1 at Ser-642 in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at Ser-131, leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.

Enzyme Numbers (IUBMB) for BRSK1 Gene

Gene Ontology (GO) - Molecular Function for BRSK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 14976552
GO:0043015 gamma-tubulin binding ISS --
GO:0050321 tau-protein kinase activity ISS --
genes like me logo Genes that share ontologies with BRSK1: view
genes like me logo Genes that share phenotypes with BRSK1: view

Animal Models for BRSK1 Gene

MGI Knock Outs for BRSK1:

Animal Model Products

  • Taconic Biosciences Mouse Models for BRSK1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BRSK1 Gene

Localization for BRSK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRSK1 Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell junction, synapse. Note=Localizes to synaptic vesicles in neurons (By similarity). Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS-induced DNA damage. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BRSK1 Gene COMPARTMENTS Subcellular localization image for BRSK1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for BRSK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with BRSK1: view

Pathways & Interactions for BRSK1 Gene

genes like me logo Genes that share pathways with BRSK1: view

Pathways by source for BRSK1 Gene

3 Cell Signaling Technology pathways for BRSK1 Gene
1 BioSystems pathway for BRSK1 Gene

SIGNOR curated interactions for BRSK1 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for BRSK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IDA 15150265
GO:0006974 cellular response to DNA damage stimulus IDA 15150265
GO:0007409 axonogenesis ISS --
GO:0010212 NOT response to ionizing radiation IDA 15150265
GO:0030010 establishment of cell polarity ISS --
genes like me logo Genes that share ontologies with BRSK1: view

Drugs & Compounds for BRSK1 Gene

(3) Drugs for BRSK1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sumatriptan Approved, Investigational Pharma Full agonist, Agonist 97
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0

(1) Additional Compounds for BRSK1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with BRSK1: view

Transcripts for BRSK1 Gene

Unigene Clusters for BRSK1 Gene

BR serine/threonine kinase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BRSK1 Gene

No ASD Table

Relevant External Links for BRSK1 Gene

GeneLoc Exon Structure for
BRSK1
ECgene alternative splicing isoforms for
BRSK1

Expression for BRSK1 Gene

mRNA expression in normal human tissues for BRSK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BRSK1 Gene

This gene is overexpressed in Brain - Cortex (x6.3), Brain - Frontal Cortex (BA9) (x5.0), Brain - Anterior cingulate cortex (BA24) (x5.0), and Brain - Hippocampus (x4.4).

Protein differential expression in normal tissues from HIPED for BRSK1 Gene

This gene is overexpressed in Brain (44.0), Fetal Brain (6.8), and Serum (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BRSK1 Gene



SOURCE GeneReport for Unigene cluster for BRSK1 Gene Hs.182081

mRNA Expression by UniProt/SwissProt for BRSK1 Gene

Q8TDC3-BRSK1_HUMAN
Tissue specificity: Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle.
genes like me logo Genes that share expression patterns with BRSK1: view

Protein tissue co-expression partners for BRSK1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for BRSK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BRSK1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BRSK1 35
  • 92.77 (n)
  • 99.07 (a)
BRSK1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BRSK1 35
  • 92.84 (n)
  • 98.84 (a)
BRSK1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Brsk1 35
  • 91.17 (n)
  • 99.1 (a)
Brsk1 16
Brsk1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Brsk1 35
  • 90.96 (n)
  • 98.97 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia BRSK1 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BRSK1 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 25 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia BRSK1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia brsk1 35
  • 71.52 (n)
  • 84 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC558390 35
  • 70.81 (n)
  • 81.29 (a)
BRSK1 (1 of 2) 36
  • 67 (a)
OneToMany
BRSK1 (2 of 2) 36
  • 67 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sff 36
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sad-1 36
  • 42 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GIN4 36
  • 19 (a)
ManyToMany
HSL1 36
  • 16 (a)
ManyToMany
KCC4 36
  • 21 (a)
ManyToMany
GIN4 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
OneToMany
Species with no ortholog for BRSK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BRSK1 Gene

ENSEMBL:
Gene Tree for BRSK1 (if available)
TreeFam:
Gene Tree for BRSK1 (if available)

Paralogs for BRSK1 Gene

Paralogs for BRSK1 Gene

genes like me logo Genes that share paralogs with BRSK1: view

Variants for BRSK1 Gene

Sequence variations from dbSNP and Humsavar for BRSK1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_040394 A gastric adenocarcinoma sample
VAR_040395 A lung large cell carcinoma sample
VAR_040396 A metastatic melanoma sample
rs55892637 - 55,304,795(+) CGGGA(A/C)CCCGG nc-transcript-variant, reference, missense
VAR_040398 -

Structural Variations from Database of Genomic Variants (DGV) for BRSK1 Gene

Variant ID Type Subtype PubMed ID
dgv4016n71 CNV Loss 21882294
nsv912457 CNV Loss 21882294
nsv912458 CNV Loss 21882294
nsv912459 CNV Loss 21882294
nsv912460 CNV Loss 21882294
esv1551083 CNV Insertion 17803354

Variation tolerance for BRSK1 Gene

Residual Variation Intolerance Score: 5.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.83; 58.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BRSK1 Gene

HapMap Linkage Disequilibrium report
BRSK1
Human Gene Mutation Database (HGMD)
BRSK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRSK1 Gene

Disorders for BRSK1 Gene

Relevant External Links for BRSK1

Genetic Association Database (GAD)
BRSK1
Human Genome Epidemiology (HuGE) Navigator
BRSK1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BRSK1

No disorders were found for BRSK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BRSK1 Gene

Publications for BRSK1 Gene

  1. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. (PMID: 14976552) Lizcano J.M. … Alessi D.R. (EMBO J. 2004) 2 3 4 67
  2. Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function. (PMID: 15150265) Lu R. … Nakanishi M. (J. Biol. Chem. 2004) 3 23
  3. Decreased expression and prognostic role of cytoplasmic BRSK1 in human breast carcinoma: correlation with Jab1 stability and PI3K/Akt pathway. (PMID: 25036402) Wang H. … Ni Q.C. (Exp. Mol. Pathol. 2014) 3
  4. Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. (PMID: 25184681) Hill S.J. … Livingston D.M. (Genes Dev. 2014) 3
  5. Synapses of amphids defective (SAD-A) kinase promotes glucose- stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic beta-Cells. (PMID: 22669945) Nie J. … Shi Y. (J. Biol. Chem. 2012) 3

Products for BRSK1 Gene

Sources for BRSK1 Gene

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