Aliases for BRS3 Gene
External Ids for BRS3 Gene
The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension. [provided by RefSeq, Sep 2011]
GeneCards Summary for BRS3 Gene
BRS3 (Bombesin-Like Receptor 3) is a Protein Coding gene. Diseases associated with BRS3 include lung cancer and prostate cancer. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include bombesin receptor activity. An important paralog of this gene is EDNRB.
UniProtKB/Swiss-Prot for BRS3 Gene
Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system
Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: a GRP-preferring receptor (BB1 receptor), a NMB-preferring receptor (BB2 receptor) and an orphan receptor (bb3 receptor). The receptors are Gq/11-coupled and are involved in the regulation of many biological functions including sensory transmission, thermoregulation, feeding, pituitary, gastric and pancreatic secretion. They may also be involved in tissue development, proliferation and differentiation.