Aliases for BRS3 Gene
External Ids for BRS3 Gene
Previous GeneCards Identifiers for BRS3 Gene
The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension. [provided by RefSeq, Sep 2011]
GeneCards Summary for BRS3 Gene
BRS3 (Bombesin-Like Receptor 3) is a Protein Coding gene. Diseases associated with BRS3 include lung cancer and obesity. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include G-protein coupled receptor activity and bombesin receptor activity. An important paralog of this gene is EDNRB.
UniProtKB/Swiss-Prot for BRS3 Gene
Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system
Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: BB1, BB2 and an orphan receptor (bb3).