Free for academic non-profit institutions. Other users need a Commercial license

Aliases for BRS3 Gene

Aliases for BRS3 Gene

  • Bombesin-Like Receptor 3 2 3
  • BRS-3 3 4
  • Bombesin Receptor Subtype 3 3
  • Bombesin Receptor Subtype-3 3
  • G-Protein Coupled Receptor 3
  • BB3 3

External Ids for BRS3 Gene

Previous GeneCards Identifiers for BRS3 Gene

  • GC0XP130142
  • GC0XP132415
  • GC0XP133514
  • GC0XP134275
  • GC0XP135295
  • GC0XP135397
  • GC0XP135570
  • GC0XP124840

Summaries for BRS3 Gene

Entrez Gene Summary for BRS3 Gene

  • The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension. [provided by RefSeq, Sep 2011]

GeneCards Summary for BRS3 Gene

BRS3 (Bombesin-Like Receptor 3) is a Protein Coding gene. Diseases associated with BRS3 include lung cancer and prostate cancer. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include bombesin receptor activity. An important paralog of this gene is EDNRB.

UniProtKB/Swiss-Prot for BRS3 Gene

  • Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system

Tocris Summary for BRS3 Gene

  • Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: a GRP-preferring receptor (BB1 receptor), a NMB-preferring receptor (BB2 receptor) and an orphan receptor (bb3 receptor). The receptors are Gq/11-coupled and are involved in the regulation of many biological functions including sensory transmission, thermoregulation, feeding, pituitary, gastric and pancreatic secretion. They may also be involved in tissue development, proliferation and differentiation.

Gene Wiki entry for BRS3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRS3 Gene

Genomics for BRS3 Gene

Regulatory Elements for BRS3 Gene

Genomic Location for BRS3 Gene

136,482,362 bp from pter
136,493,780 bp from pter
11,419 bases
Plus strand

Genomic View for BRS3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BRS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRS3 Gene

Proteins for BRS3 Gene

  • Protein details for BRS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Bombesin receptor subtype-3
    Protein Accession:
    Secondary Accessions:

    Protein attributes for BRS3 Gene

    399 amino acids
    Molecular mass:
    44411 Da
    Quaternary structure:
    • Interacts with C6orf89.

neXtProt entry for BRS3 Gene

Proteomics data for BRS3 Gene at MOPED

Post-translational modifications for BRS3 Gene

  • Glycosylation at Asn10 and Asn18
  • Modification sites at PhosphoSitePlus

Other Protein References for BRS3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for BRS3 Gene

Domains for BRS3 Gene

Gene Families for BRS3 Gene

Suggested Antigen Peptide Sequences for BRS3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with BRS3: view

Function for BRS3 Gene

Molecular function for BRS3 Gene

GENATLAS Biochemistry:
releasing peptide receptor,epidermal carcinoma
UniProtKB/Swiss-Prot Function:
Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system

Gene Ontology (GO) - Molecular Function for BRS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004946 bombesin receptor activity IEA --
genes like me logo Genes that share ontologies with BRS3: view
genes like me logo Genes that share phenotypes with BRS3: view

Animal Models for BRS3 Gene

MGI Knock Outs for BRS3:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BRS3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for BRS3 Gene

Localization for BRS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRS3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for BRS3 Gene COMPARTMENTS Subcellular localization image for BRS3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for BRS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043005 neuron projection IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with BRS3: view

Pathways for BRS3 Gene

genes like me logo Genes that share pathways with BRS3: view

Pathways by source for BRS3 Gene

PCR Array Products

Interacting Proteins for BRS3 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000359682 for BRS3 Gene via STRING

Gene Ontology (GO) - Biological Process for BRS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006006 glucose metabolic process TAS 9367152
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0008217 regulation of blood pressure TAS 9367152
GO:0008343 adult feeding behavior TAS 9367152
GO:0031989 bombesin receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with BRS3: view

Compounds for BRS3 Gene

(5) Tocris Compounds for BRS3 Gene

Compound Action Cas Number
BIM 23042 Selective neuromedin B receptor antagonist (NMB-R, BB1) [111857-96-6]
Bombesin Involved in gastrointestinal tract function [31362-50-2]
GRP (human) Endogenous GRP receptor agonist [93755-85-2]
GRP (porcine) Endogenous GRP receptor agonist [74815-57-9]
PD 176252 GRP (BB2) and NMB (BB1) receptor antagonist [204067-01-6]

(1) HMDB Compounds for BRS3 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(12) IUPHAR Ligand for BRS3 Gene

Ligand Type Action Affinity Pubmed IDs
[D-Phe6,beta-Ala11,Phe13,Nle14]bombesin-(6-14) Agonist Full agonist 10.32
N1-(2-Phenylethyl)-2R)-2-{[4-chorobenzoyl)-hydrazino] carboxamido}3-(1H-3-indolyl)propanamide Agonist Full agonist 10.2
phenylacetyl-Ala,DTrp-phenthylamide Agonist Full agonist 8.92
[125I][D-Tyr6,beta-Ala11,Phe13,Nle14]bombesin-(6-14) Agonist Full agonist 8.4
[D-Tyr6,(R)-APA11,Phe13,Nle14]bombesin-(6-14) Agonist Full agonist 8.37
[D-Tyr6,Apa-4Cl11,Phe13,Nle14]bombesin-(6-14) Agonist Full agonist 8.1
Bag-1 Agonist Full agonist 7.74
Ac-Phe-Trp-Ala-His(tauBZL)-Nip-Gly-Arg-NH2 Agonist Full agonist 7.31
Bag-2 Agonist Full agonist 7.09
D-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-Nal-NH2 Antagonist Antagonist 5.61
bantag-1 Antagonist Antagonist 5.36
MK-5046 Agonist Full agonist 5

(4) Novoseek inferred chemical compound relationships for BRS3 Gene

Compound -log(P) Hits PubMed IDs
ozone 17.3 6
glucose 10.9 2
calcium 4.31 1
arginine 0 1
genes like me logo Genes that share compounds with BRS3: view

Transcripts for BRS3 Gene

mRNA/cDNA for BRS3 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BRS3 Gene

Bombesin-like receptor 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BRS3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BRS3 Gene

No ASD Table

Relevant External Links for BRS3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BRS3 Gene

mRNA expression in normal human tissues for BRS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BRS3 Gene

This gene is overexpressed in Fallopian Tube (9.5), Brain - Hypothalamus (8.5), Brain - Nucleus accumbens (basal ganglia) (8.5), and Ovary (7.1).

Protein differential expression in normal tissues for BRS3 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BRS3 Gene

SOURCE GeneReport for Unigene cluster for BRS3 Gene Hs.121484

mRNA Expression by UniProt/SwissProt for BRS3 Gene

Tissue specificity: In germ cells in testis. Lung carcinoma cells
genes like me logo Genes that share expressions with BRS3: view

Expression partners for BRS3 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for BRS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for BRS3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BRS3 35
  • 88.27 (n)
  • 86.43 (a)
BRS3 36
  • 86 (a)
(Canis familiaris)
Mammalia BRS3 35
  • 90.87 (n)
  • 89.45 (a)
BRS3 36
  • 89 (a)
(Mus musculus)
Mammalia Brs3 35
  • 87.35 (n)
  • 85.43 (a)
Brs3 16
Brs3 36
  • 85 (a)
(Pan troglodytes)
Mammalia BRS3 35
  • 99.92 (n)
  • 99.75 (a)
BRS3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Brs3 35
  • 86.52 (n)
  • 86.18 (a)
(Monodelphis domestica)
Mammalia BRS3 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia BRS3 36
  • 66 (a)
(Gallus gallus)
Aves BRS3 35
  • 71.2 (n)
  • 70.51 (a)
BRS3.5 36
  • 68 (a)
(Anolis carolinensis)
Reptilia BRS3 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488712 35
  • 66.58 (n)
  • 65.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30106 37
  • 37 (a)
CCHa2r 35
  • 47.73 (n)
  • 36.09 (a)
CCHa1r 36
  • 26 (a)
CCHa2r 36
  • 26 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRGRP2 35
  • 47.95 (n)
  • 40 (a)
Species with no ortholog for BRS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BRS3 Gene

Gene Tree for BRS3 (if available)
Gene Tree for BRS3 (if available)

Paralogs for BRS3 Gene

Paralogs for BRS3 Gene

(9) SIMAP similar genes for BRS3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BRS3: view

Variants for BRS3 Gene

Sequence variations from dbSNP and Humsavar for BRS3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs5231 -- 136,487,965(+) GCAAA(A/G)GAGTA upstream-variant-2KB, utr-variant-5-prime, intron-variant
rs5232 - 136,488,271(+) ATATT(A/C)CTTAT reference, missense
rs5233 -- 136,488,420(+) GTGCC(A/T)GTGGA reference, synonymous-codon
rs5234 - 136,490,183(+) CATCC(A/T)GAAGA missense, reference
rs5235 -- 136,490,247(+) GAGGC(A/T)ATATT synonymous-codon, reference

Relevant External Links for BRS3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BRS3 Gene

Disorders for BRS3 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for BRS3 Gene in MalaCards »

(2) Diseases for BRS3 Gene

(14) Novoseek inferred disease relationships for BRS3 Gene

Disease -log(P) Hits PubMed IDs
carcinoma non-small cell lung 48.1 1
lung carcinoma 33.8 3
nsclc 33.6 4
small cell lung cancer 29.7 2
obesity 29.5 5

Relevant External Links for BRS3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with BRS3: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for BRS3 Gene

Publications for BRS3 Gene

  1. BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells. (PMID: 8383682) Fathi Z. … Battey J.F. (J. Biol. Chem. 1993) 2 3 4 23
  2. BRS-3 activation transforms the effect of human bronchial epithelial cells from PGE2 mediated inhibition to TGF-beta1 dependent promotion on proliferation and collagen synthesis of lung fibroblasts. (PMID: 17714959) Wang Y. … Qin X. (Cell Biol. Int. 2007) 3 23
  3. Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3. (PMID: 9593699) Ryan R.R. … Jensen R.T. (J. Biol. Chem. 1998) 3 23
  4. Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity. (PMID: 9367152) Ohki-Hamazaki H. … Wada K. (Nature 1997) 3 23
  5. Activation of bombesin receptor subtype-3 stimulates adhesion of lung cancer cells. (PMID: 16979789) Hou X. … Tatamoto K. (Lung Cancer 2006) 3 23

Products for BRS3 Gene

Sources for BRS3 Gene

Back to Top