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Aliases for BRS3 Gene

Aliases for BRS3 Gene

  • Bombesin Receptor Subtype 3 2 3 5
  • Bombesin Like Receptor 3 2 3
  • BRS-3 3 4
  • Bombesin Receptor Subtype-3 3
  • G-Protein Coupled Receptor 3
  • BB3R 3
  • BB3 3

External Ids for BRS3 Gene

Previous GeneCards Identifiers for BRS3 Gene

  • GC0XP130142
  • GC0XP132415
  • GC0XP133514
  • GC0XP134275
  • GC0XP135295
  • GC0XP135397
  • GC0XP135570
  • GC0XP124840

Summaries for BRS3 Gene

Entrez Gene Summary for BRS3 Gene

  • The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension. [provided by RefSeq, Sep 2011]

GeneCards Summary for BRS3 Gene

BRS3 (Bombesin Receptor Subtype 3) is a Protein Coding gene. Diseases associated with BRS3 include Lung Cancer and Obesity. Among its related pathways are Peptide ligand-binding receptors and RET signaling. GO annotations related to this gene include G-protein coupled receptor activity and bombesin receptor activity. An important paralog of this gene is GRPR.

UniProtKB/Swiss-Prot for BRS3 Gene

  • Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Tocris Summary for BRS3 Gene

  • Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: BB1, BB2 and an orphan receptor (bb3).

Gene Wiki entry for BRS3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRS3 Gene

Genomics for BRS3 Gene

Regulatory Elements for BRS3 Gene


Genomic Location for BRS3 Gene

Chromosome:
X
Start:
136,463,815 bp from pter
End:
136,493,780 bp from pter
Size:
29,966 bases
Orientation:
Plus strand

Genomic View for BRS3 Gene

Genes around BRS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRS3 Gene

Proteins for BRS3 Gene

  • Protein details for BRS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32247-BRS3_HUMAN
    Recommended name:
    Bombesin receptor subtype-3
    Protein Accession:
    P32247

    Protein attributes for BRS3 Gene

    Size:
    399 amino acids
    Molecular mass:
    44411 Da
    Quaternary structure:
    • Interacts with C6orf89.

neXtProt entry for BRS3 Gene

Post-translational modifications for BRS3 Gene

  • Glycosylation at Asn10 and posLast=1818
  • Modification sites at PhosphoSitePlus

Other Protein References for BRS3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BRS3 Gene

Domains & Families for BRS3 Gene

Gene Families for BRS3 Gene

Suggested Antigen Peptide Sequences for BRS3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P32247

UniProtKB/Swiss-Prot:

BRS3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with BRS3: view

Function for BRS3 Gene

Molecular function for BRS3 Gene

GENATLAS Biochemistry:
releasing peptide receptor,epidermal carcinoma
UniProtKB/Swiss-Prot Function:
Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Gene Ontology (GO) - Molecular Function for BRS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004946 bombesin receptor activity IEA,TAS --
GO:0008528 G-protein coupled peptide receptor activity IEA --
genes like me logo Genes that share ontologies with BRS3: view
genes like me logo Genes that share phenotypes with BRS3: view

Animal Models for BRS3 Gene

MGI Knock Outs for BRS3:

Animal Model Products

  • Taconic Biosciences Mouse Models for BRS3

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for BRS3
  • Applied Biological Materials Clones for BRS3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BRS3 Gene

Localization for BRS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRS3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BRS3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for BRS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane NAS,IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS,IEA --
GO:0043005 neuron projection IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with BRS3: view

Pathways & Interactions for BRS3 Gene

genes like me logo Genes that share pathways with BRS3: view

Pathways by source for BRS3 Gene

Gene Ontology (GO) - Biological Process for BRS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006006 glucose metabolic process TAS 9367152
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0008217 regulation of blood pressure TAS 9367152
GO:0008343 adult feeding behavior TAS 9367152
genes like me logo Genes that share ontologies with BRS3: view

No data available for SIGNOR curated interactions for BRS3 Gene

Drugs & Compounds for BRS3 Gene

(20) Drugs for BRS3 Gene - From: DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[D-Tyr<sup>6</sup>,(R)-APA<sup>11</sup>,Phe<sup>13</sup>,Nle<sup>14</sup>]bombesin-(6-14) Pharma Full agonist, Agonist 0
[D-Tyr<sup>6</sup>,Apa-4Cl<sup>11</sup>,Phe<sup>13</sup>,Nle<sup>14</sup>]bombesin-(6-14) Pharma Full agonist, Agonist 0
Bag-1 Pharma Full agonist, Agonist 0
Bag-2 Pharma Full agonist, Agonist 0
bantag-1 Pharma Antagonist 0

(4) Additional Compounds for BRS3 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I][D-Tyr<sup>6</sup>,beta-Ala<sup>11</sup>,Phe<sup>13</sup>,Nle<sup>14</sup>]bombesin-(6-14)
Full agonist, Agonist
[D-Phe<sup>6</sup>,beta-Ala<sup>11</sup>,Phe<sup>13</sup>,Nle<sup>14</sup>]bombesin-(6-14)
Full agonist, Agonist
Ac-Phe-Trp-Ala-His(tauBZL)-Nip-Gly-Arg-NH<sub>2</sub>
Full agonist, Agonist

(5) Tocris Compounds for BRS3 Gene

Compound Action Cas Number
Bombesin Involved in gastrointestinal tract function 31362-50-2
GRP (human) Endogenous GRP receptor agonist 93755-85-2
GRP (porcine) Endogenous GRP receptor agonist 74815-57-9
Neuromedin B (porcine) Mammalian bombesin-like peptide 87096-84-2
PD 176252 GRP (BB2) and NMB (BB1) receptor antagonist 204067-01-6
genes like me logo Genes that share compounds with BRS3: view

Transcripts for BRS3 Gene

mRNA/cDNA for BRS3 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BRS3 Gene

Bombesin-like receptor 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for BRS3
  • Applied Biological Materials Clones for BRS3

Alternative Splicing Database (ASD) splice patterns (SP) for BRS3 Gene

No ASD Table

Relevant External Links for BRS3 Gene

GeneLoc Exon Structure for
BRS3
ECgene alternative splicing isoforms for
BRS3

Expression for BRS3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BRS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BRS3 Gene

This gene is overexpressed in Fallopian Tube (x9.5), Brain - Hypothalamus (x8.5), Brain - Nucleus accumbens (basal ganglia) (x8.5), and Ovary (x7.1).

Protein differential expression in normal tissues from HIPED for BRS3 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BRS3 Gene



Protein tissue co-expression partners for BRS3 Gene

NURSA nuclear receptor signaling pathways regulating expression of BRS3 Gene:

BRS3

SOURCE GeneReport for Unigene cluster for BRS3 Gene:

Hs.121484

mRNA Expression by UniProt/SwissProt for BRS3 Gene:

P32247-BRS3_HUMAN
Tissue specificity: In germ cells in testis. Lung carcinoma cells.
genes like me logo Genes that share expression patterns with BRS3: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for BRS3 Gene

Orthologs for BRS3 Gene

This gene was present in the common ancestor of animals.

Orthologs for BRS3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BRS3 34 35
  • 99.92 (n)
dog
(Canis familiaris)
Mammalia BRS3 34 35
  • 90.87 (n)
cow
(Bos Taurus)
Mammalia BRS3 34 35
  • 88.27 (n)
mouse
(Mus musculus)
Mammalia Brs3 34 16 35
  • 87.35 (n)
rat
(Rattus norvegicus)
Mammalia Brs3 34
  • 86.52 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia BRS3 35
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BRS3 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves BRS3 34
  • 71.2 (n)
BRS3.5 35
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BRS3 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488712 34
  • 66.58 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta GPRGRP2 34
  • 47.95 (n)
fruit fly
(Drosophila melanogaster)
Insecta CCHa2r 35 34
  • 47.73 (n)
ManyToMany
CG30106 36
  • 37 (a)
CCHa1r 35
  • 26 (a)
ManyToMany
Species where no ortholog for BRS3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BRS3 Gene

ENSEMBL:
Gene Tree for BRS3 (if available)
TreeFam:
Gene Tree for BRS3 (if available)

Paralogs for BRS3 Gene

Paralogs for BRS3 Gene

(9) SIMAP similar genes for BRS3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BRS3: view

Variants for BRS3 Gene

Sequence variations from dbSNP and Humsavar for BRS3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000432052 -- 136,488,672(+) TGTGA(C/G)ATTGG intron-variant
rs1001041241 -- 136,487,812(+) CCCCA(A/G)CAGGG upstream-variant-2KB
rs1001536047 -- 136,486,857(+) CAAAT(A/G)ATGAT upstream-variant-2KB
rs1002810040 -- 136,486,677(+) CCAAA(C/T)AGTGC upstream-variant-2KB
rs1004999274 -- 136,486,045(+) CTGTG(A/G)TGTGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for BRS3 Gene

Variant ID Type Subtype PubMed ID
esv3577408 CNV gain 25503493

Variation tolerance for BRS3 Gene

Residual Variation Intolerance Score: 67.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BRS3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BRS3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRS3 Gene

Disorders for BRS3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for BRS3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • lung cancer, protection against
obesity
  • obesity, association with
- elite association - COSMIC cancer census association via MalaCards
Search BRS3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BRS3

Genetic Association Database (GAD)
BRS3
Human Genome Epidemiology (HuGE) Navigator
BRS3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BRS3
genes like me logo Genes that share disorders with BRS3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BRS3 Gene

Publications for BRS3 Gene

  1. BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells. (PMID: 8383682) Fathi Z. … Battey J.F. (J. Biol. Chem. 1993) 2 3 4 22 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells. (PMID: 17355223) Tan Y.R. … Weber H.C. (Biochem. J. 2007) 3 22 64
  4. BRS-3 activation transforms the effect of human bronchial epithelial cells from PGE2 mediated inhibition to TGF-beta1 dependent promotion on proliferation and collagen synthesis of lung fibroblasts. (PMID: 17714959) Wang Y. … Qin X. (Cell Biol. Int. 2007) 3 22 64
  5. Activation of bombesin receptor subtype-3 stimulates adhesion of lung cancer cells. (PMID: 16979789) Hou X. … Tatamoto K. (Lung Cancer 2006) 3 22 64

Products for BRS3 Gene

  • Addgene plasmids for BRS3

Sources for BRS3 Gene

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