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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BRS3 Gene

protein-coding   GIFtS: 64
GCID: GC0XP135570

Bombesin-Like Receptor 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Bombesin-Like Receptor 31 2
BRS-32 3
Bombesin Receptor Subtype 32
Bombesin Receptor Subtype-32
G-Protein Coupled Receptor2

External Ids:    HGNC: 11131   Entrez Gene: 6802   Ensembl: ENSG000001022397   OMIM: 3001075   UniProtKB: P322473   

Export aliases for BRS3 gene to outside databases

Previous GC identifers: GC0XP130142 GC0XP132415 GC0XP133514 GC0XP134275 GC0XP135295 GC0XP135397 GC0XP124840


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BRS3 Gene:
The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This
binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological
effects including regulation of metabolic rate, glucose metabolism, and hypertension. (provided by RefSeq, Sep
2011)

GeneCards Summary for BRS3 Gene: 
BRS3 (bombesin-like receptor 3) is a protein-coding gene. Diseases associated with BRS3 include ovarian epithelial cancer, and hypertension, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Peptide GPCRs. GO annotations related to this gene include bombesin receptor activity. An important paralog of this gene is EDNRA.

UniProtKB/Swiss-Prot: BRS3_HUMAN, P32247
Function: Role in sperm cell division, maturation, or function. This receptor mediates its action by association
with G proteins that activate a phosphatidylinositol-calcium second messenger system

summary for BRS3 Gene:
Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B
(NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: a GRP-preferring receptor
(BB1 receptor), a NMB-preferring receptor (BB2 receptor) and an orphan receptor (bb3 receptor). The
receptors are Gq/11-coupled and are involved in the regulation of many biological functions including
sensory transmission, thermoregulation, feeding, pituitary, gastric and pancreatic secretion. They may also
be involved in tissue development, proliferation and differentiation.

Gene Wiki entry for BRS3 (Bombesin-like receptor 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011786.16  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BRS3 gene promoter:
         Pbx1a   HSF1 (long)   STAT5A   Evi-1   Gfi-1   PPAR-gamma1   c-Rel   FOXC1   HSF1short   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBRS3 promoter sequence
   Search SABiosciences Chromatin IP Primers for BRS3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BRS3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.3   Ensembl cytogenetic band:  Xq26.3   HGNC cytogenetic band: Xq26.3

BRS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRS3 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP135570:  view genomic region     (about GC identifiers)

Start:
135,570,046 bp from pter      End:
135,575,939 bp from pter
Size:
5,894 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BRS3_HUMAN, P32247 (See protein sequence)
Recommended Name: Bombesin receptor subtype-3  
Size: 399 amino acids; 44411 Da
Subunit: Interacts with C6orf89
Subcellular location: Cell membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for BRS3: NX_P32247

Explore proteomics data for BRS3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P32247

  • BRS3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BRS3 Protein Expression
    REFSEQ proteins: NP_001718.1  
    ENSEMBL proteins: 
     ENSP00000359682  
    Reactome Protein details: P32247
    Human Recombinant Protein Products for BRS3: 
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    Cloud-Clone Corp. Proteins for BRS3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--
    GO:0043005neuron projection IEA--
    GO:0043025neuronal cell body IEA--

    BRS3 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for BRS3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BRS: GPCR / Class A : Bombesin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: BB3 receptor 
    Class A Orphans
    Bombesin receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001556 Bombsn_rcpt
     IPR000276 GPCR_Rhodpsn
     IPR001560 Bombesin_rcpt_3

    Graphical View of Domain Structure for InterPro Entry P32247

    ProtoNet protein and cluster: P32247

    2 Blocks protein domains:
    IPB001556 Bombesin receptor signature
    IPB001560 Type 3 bombesin receptor signature


    UniProtKB/Swiss-Prot: BRS3_HUMAN, P32247
    Similarity: Belongs to the G-protein coupled receptor 1 family


    BRS3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BRS3_HUMAN, P32247
    Function: Role in sperm cell division, maturation, or function. This receptor mediates its action by association
    with G proteins that activate a phosphatidylinositol-calcium second messenger system

         Genatlas biochemistry entry for BRS3:
    releasing peptide receptor,epidermal carcinoma

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004946bombesin receptor activity IEA--
         
    BRS3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for BRS3:
     Decreased Salmonella enterica   Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Brs3):
     adipose tissue  behavior/neurological  cardiovascular system  growth/size  homeostasis/metabolism 

    BRS3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for BRS3: Brs3tm1Lex Brs3tm1Hoh Brs3tm1Jfb

       inGenious Targeting Laboratory - Custom generated mouse model solutions for BRS3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BRS3

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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BRS3 

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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRS3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BRS3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.41
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    Peptide ligand-binding receptors0.60
    2Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q0.46
    Peptide GPCRs0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    4G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    5Development Endothelin-1/EDNRA signaling
    Cytoskeleton remodeling FAK signaling0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for BRS3
        Cytoskeleton remodeling FAK signaling
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q


    1 GeneGo (Thomson Reuters) Pathway for BRS3
        Cytoskeleton remodeling FAK signaling

    2 BioSystems Pathways for BRS3
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    5/8        Reactome Pathways for BRS3 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR
    GPCR ligand binding


    1         Kegg Pathway  (Kegg details for BRS3):
        Neuroactive ligand-receptor interaction


    BRS3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BRS3

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006006glucose metabolic process TAS9367152
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0008217regulation of blood pressure TAS9367152
    GO:0008343adult feeding behavior TAS9367152

    BRS3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BRS3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for BRS3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BombesinInvolved in gastrointestinal tract function[31362-50-2]
    PD 176252GRP (BB2) and NMB (BB1) receptor antagonist[204067-01-6]
    GRP (human)Endogenous GRP receptor agonist[93755-85-2]
    GRP (porcine)Endogenous GRP receptor agonist[74815-57-9]
    Neuromedin B (porcine)Mammalian bombesin-like peptide[87096-84-2]

    1 HMDB Compound for BRS3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    10/12 IUPHAR Ligands for BRS3 (BB3 receptor) (see all 12)    About this table 
    LigandTypeActionAffinityPubmed IDs
    N1-(2-Phenylethyl)-2R)-2-{[4-chorobenzoyl)-hydrazino] carboxamido}3-(1H-3-indolyl)propanamide
    AgonistFull agonist9.2 - 10.212723954
    phenylacetyl-Ala,DTrp-phenthylamide
    AgonistFull agonist7.85 - 8.9219580790 12212809
    bantag-1
    AntagonistAntagonist8.6 - 8.720096642
    [125I][D-Tyr6,β-Ala11,Phe13,Nle14]bombesin-(6-14)
    AgonistFull agonist8 - 8.49325344
    [D-Phe6,β-Ala11,Phe13,Nle14]bombesin-(6-14)
    AgonistFull agonist8.05 - 8.389325344
    [D-Tyr6,(R)-APA11,Phe13,Nle14]bombesin-(6-14)
    AgonistFull agonist7.53 - 8.3718006692 20438784
    [D-Tyr6,Apa-4Cl11,Phe13,Nle14]bombesin-(6-14)
    AgonistFull agonist8.115102928
    Bag-1
    AgonistFull agonist7.7420096642
    MK-5046
    AgonistFull agonist7.6--
    Ac-Phe-Trp-Ala-His(τBZL)-Nip-Gly-Arg-NH2
    AgonistFull agonist6.24 - 7.3118006692 20438784

    4 Novoseek inferred chemical compound relationships for BRS3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ozone 17.3 8 17355223 (6)
    glucose 10.9 2 9367152 (1), 18006692 (1)
    calcium 4.31 1 12212809 (1)
    arginine 0 2 10425452 (1)

    Search CenterWatch for drugs/clinical trials and news about BRS3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BRS3 gene: 
    NM_001727.1  

    Unigene Cluster for BRS3:

    Bombesin-like receptor 3
    Hs.121484  [show with all ESTs]
    Unigene Representative Sequence: NM_001727
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000370648(uc004ezv.1)
    miRNA
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    Additional mRNA sequence: 

    AY585193.1 L08893.1 

    1 DOTS entry:

    DT.206356 

    8 AceView cDNA sequences:

    L08893 AY585193 BX104415 NM_001727 BG707051 AW291491 BV198960 AI761066 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BRS3 expression in normal human tissues (normalized intensities)      BRS3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTTCATTT
    BRS3 Expression
    About this image


    BRS3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Neural Tube (Nervous System)
             Metencephalon

    See BRS3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BRS3

    SOURCE GeneReport for Unigene cluster: Hs.121484

    UniProtKB/Swiss-Prot: BRS3_HUMAN, P32247
    Tissue specificity: In germ cells in testis. Lung carcinoma cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including BRS3: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Obesity in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRS3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for BRS3 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Brs31 , 5 bombesin-like receptor 31, 5 87.35(n)1
    85.43(a)1
      X (30.78 cM)5
    122091  NM_009766.31  NP_033896.21 
     570430745 
    chicken
    (Gallus gallus)
    Aves BRS31 bombesin-like receptor 3 71.08(n)
    69.97(a)
      378927  NM_204406.1  NP_989737.1 
    lizard
    (Anolis carolinensis)
    Reptilia BRS36
    Uncharacterized protein
    65(a)
    1 ↔ 1
    AAWZ02037394(164-14027)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG301063 G-protein coupled receptor protein
    signaling pathway more
    37(a)   54D3   --


    ENSEMBL Gene Tree for BRS3 (if available)
    TreeFam Gene Tree for BRS3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BRS3 gene
    EDNRA2  GPR372  GRPR2  EDNRB2  NMBR2  GPR37L12  
    9 SIMAP similar genes for BRS3 using alignment to 1 protein entry:     BRS3_HUMAN:
    GRPR    NMBR    GALR1    GPR83    NPY2R    PRLHR
    NPY6R    NPBWR1    NPBWR2

    BRS3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/106 SNPs in BRS3 are shown (see all 106)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1860034941,2
    --135568312(+) GAGCCC/GTTTTC 1 -- us2k10--------
    rs1896126561,2
    --135568362(+) TTACTA/GGAGTG 1 -- us2k10--------
    rs1825853551,2
    --135568414(+) TCCCCC/TGCACC 1 -- us2k10--------
    rs1442608241,2
    --135568415(+) CCCCCA/GCACCC 1 -- us2k10--------
    rs12036061,2
    C,F,O,A,H--135568554(+) GAGGTA/CATTGA 1 -- us2k119--NA NS EA WA 2132
    rs2022025361,2
    C--135568630(+) TTGTTA/G/TTTCCC 1 -- us2k10--------
    rs1853120321,2
    --135568959(+) TAAACA/GTCATC 1 -- us2k10--------
    rs1905124381,2
    --135569039(+) AAGTTC/GTTTTG 1 -- us2k10--------
    rs1483942651,2
    --135570095(+) AAGCAG/TGCTGG 1 -- us2k10--------
    rs52311,2
    C,H--135570124(+) GCAAAG/AGAGTA 1 -- us2k1 ese38Minor allele frequency- A:0.01MN NS EA NA 674

    HapMap Linkage Disequilibrium report for BRS3 (135570046 - 135575939 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for BRS3: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing BRS3
    DNA2.0 Custom Variant and Variant Library Synthesis for BRS3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300107    OMIM disorders: --

    12 diseases for BRS3:    About MalaCards
    ovarian epithelial cancer    hypertension    colon adenocarcinoma    pancreatitis
    lung cancer    ovarian cancer    obesity    colorectal cancer
    adenocarcinoma    prostate cancer    prostatitis    neuronitis


    BRS3 for disorders           About GeneDecksing

    10/14 Novoseek inferred disease relationships for BRS3 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma non-small cell lung 48.1 2 9279210 (1)
    lung carcinoma 33.8 3 8383682 (3)
    nsclc 33.6 7 8959679 (1), 9279210 (1), 9325344 (1), 9593699 (1)
    small cell lung cancer 29.7 3 16979789 (2)
    obesity 29.5 7 10727011 (3), 20347296 (1), 9367152 (1)
    cancer lung 24.5 4 8959679 (1), 16979789 (1), 11166731 (1)
    ovarian carcinoma 17.7 1 10828496 (1)
    colorectal carcinoma 15.5 1 17395367 (1)
    cancer 7.36 1 16979789 (1)
    tumors 1.65 10 10828496 (3), 15634004 (1), 16967266 (1), 18006692 (1) (see all 5)

    Genetic Association Database (GAD): BRS3
    Human Genome Epidemiology (HuGE) Navigator: BRS3 (3 documents)

    Export disorders for BRS3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BRS3 gene, integrated from 9 sources (see all 74):
    (articles sorted by number of sources associating them with BRS3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells. (PubMed id 8383682)1, 2, 3, 9 Fathi Z.... Battey J.F. (1993)
    2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    4. Organization and chromosomal localization of the gene for the human bombesin receptor subtype expressed in pregnant uterus. (PubMed id 8131855)1, 2 Gorbulev V.... Fahrenholz F. (1994)
    5. PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells. (PubMed id 17355223)1, 9 Tan Y.R....Weber H.C. (2007)
    6. Activation of bombesin receptor subtype-3 stimulates adhesion of lung cancer cells. (PubMed id 16979789)1, 9 Hou X....Tatamoto K. (2006)
    7. Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity. (PubMed id 9367152)1, 9 Ohki-Hamazaki H....Wada K. (1997)
    8. BRS-3 activation transforms the effect of human bronchial epithelial cells from PGE2 mediated inhibition to TGF-beta1 dependent promotion on proliferation and collagen synthesis of lung fibroblasts. (PubMed id 17714959)1, 9 Wang Y....Qin X. (2007)
    9. Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3. (PubMed id 9593699)1, 9 Ryan R.R....Jensen R.T. (1998)
    10. Bombesin receptor subtype-3 (BRS-3), a novel candidate as therapeutic molecular target in obesity and diabetes. (PubMed id 23291341)1 Ramos-Alvarez I....Gonzalez N. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 680 HGNC: 1113 AceView: BRS3 Ensembl:ENSG00000102239 euGenes: HUgn680
    ECgene: BRS3 Kegg: 680 H-InvDB: BRS3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BRS3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BRS3 gene:
    Search GeneIP for patents involving BRS3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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