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BRS3 Gene

protein-coding   GIFtS: 64
GCID: GC0XP135570

Bombesin-Like Receptor 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Bombesin-Like Receptor 31 2
BRS-32 3
BB32
Bombesin Receptor Subtype 32
Bombesin Receptor Subtype-32
G-Protein Coupled Receptor2

External Ids:    HGNC: 11131   Entrez Gene: 6802   Ensembl: ENSG000001022397   OMIM: 3001075   UniProtKB: P322473   

Export aliases for BRS3 gene to outside databases

Previous GC identifers: GC0XP130142 GC0XP132415 GC0XP133514 GC0XP134275 GC0XP135295 GC0XP135397 GC0XP124840


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BRS3 Gene:
The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This
binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological
effects including regulation of metabolic rate, glucose metabolism, and hypertension. (provided by RefSeq, Sep
2011)

GeneCards Summary for BRS3 Gene:
BRS3 (bombesin-like receptor 3) is a protein-coding gene. Diseases associated with BRS3 include ovarian epithelial cancer, and hypertension. GO annotations related to this gene include bombesin receptor activity. An important paralog of this gene is EDNRA.

UniProtKB/Swiss-Prot: BRS3_HUMAN, P32247
Function: Role in sperm cell division, maturation, or function. This receptor mediates its action by association
with G proteins that activate a phosphatidylinositol-calcium second messenger system

summary for BRS3 Gene:
Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B
(NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: a GRP-preferring receptor
(BB1 receptor), a NMB-preferring receptor (BB2 receptor) and an orphan receptor (bb3 receptor). The
receptors are Gq/11-coupled and are involved in the regulation of many biological functions including
sensory transmission, thermoregulation, feeding, pituitary, gastric and pancreatic secretion. They may also
be involved in tissue development, proliferation and differentiation.

Gene Wiki entry for BRS3 (Bombesin-like receptor 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_011786.17  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BRS3 gene promoter:
         Pbx1a   HSF1 (long)   STAT5A   Evi-1   Gfi-1   PPAR-gamma1   c-Rel   FOXC1   HSF1short   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBRS3 promoter sequence
   Search Chromatin IP Primers for BRS3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BRS3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq26.3   Ensembl cytogenetic band:  Xq26.3   HGNC cytogenetic band: Xq26.3

BRS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRS3 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP135570:  view genomic region     (about GC identifiers)

Start:
135,570,046 bp from pter      End:
135,575,939 bp from pter
Size:
5,894 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: BRS3_HUMAN, P32247 (See protein sequence)
Recommended Name: Bombesin receptor subtype-3  
Size: 399 amino acids; 44411 Da
Subunit: Interacts with C6orf89

Explore the universe of human proteins at neXtProt for BRS3: NX_P32247

Explore proteomics data for BRS3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn10, Asn18
  • Modification sites at PhosphoSitePlus

  • See BRS3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001718.1  
    ENSEMBL proteins: 
     ENSP00000359682  
    Reactome Protein details: P32247

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    Cloud-Clone Corp. CLIAs for BRS3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BRS: GPCR / Class A : Bombesin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: BB3 receptor
    Class A Orphans
    Bombesin receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR001556 Bombsn_rcpt
     IPR000276 GPCR_Rhodpsn
     IPR001560 Bombesin_rcpt_3

    Graphical View of Domain Structure for InterPro Entry P32247

    ProtoNet protein and cluster: P32247

    2 Blocks protein domains:
    IPB001556 Bombesin receptor signature
    IPB001560 Type 3 bombesin receptor signature


    UniProtKB/Swiss-Prot: BRS3_HUMAN, P32247
    Similarity: Belongs to the G-protein coupled receptor 1 family


    BRS3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BRS3_HUMAN, P32247
    Function: Role in sperm cell division, maturation, or function. This receptor mediates its action by association
    with G proteins that activate a phosphatidylinositol-calcium second messenger system

         Genatlas biochemistry entry for BRS3:
    releasing peptide receptor,epidermal carcinoma

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004946bombesin receptor activity IEA--
         
    BRS3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for BRS3:
     Decreased Salmonella enterica   Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Brs3):
     adipose tissue  behavior/neurological  cardiovascular system  growth/size/body  homeostasis/metabolism 

    BRS3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for BRS3: Brs3tm1Lex Brs3tm1Hoh Brs3tm1Jfb

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BRS3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BRS3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BRS3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BRS3

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    GenScript: all cDNA clones in your preferred vector: BRS3 (NM_001727)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRS3

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRS3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BRS3_HUMAN, P32247: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--
    GO:0043005neuron projection IEA--
    GO:0043025neuronal cell body IEA--

    BRS3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BRS3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    Peptide ligand-binding receptors0.60
    2Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    5Development Endothelin 1 EDNRA signaling
    Cytoskeleton remodeling FAK signaling0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for BRS3
        Cytoskeleton remodeling FAK signaling

    2 BioSystems Pathways for BRS3
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    2 Reactome Pathways for BRS3
        Peptide ligand-binding receptors
    G alpha (q) signalling events


    1 Kegg Pathway  (Kegg details for BRS3):
        Neuroactive ligand-receptor interaction


    BRS3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BRS3: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Obesity in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for BRS3

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006006glucose metabolic process TAS9367152
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0008217regulation of blood pressure TAS9367152
    GO:0008343adult feeding behavior TAS9367152

    BRS3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for BRS3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BombesinInvolved in gastrointestinal tract function[31362-50-2]
    PD 176252GRP (BB2) and NMB (BB1) receptor antagonist[204067-01-6]
    GRP (human)Endogenous GRP receptor agonist[93755-85-2]
    GRP (porcine)Endogenous GRP receptor agonist[74815-57-9]
    Neuromedin B (porcine)Mammalian bombesin-like peptide[87096-84-2]

    1 HMDB Compound for BRS3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected IUPHAR Ligands for BRS3 (BB3 receptor) (see all 12)    About this table
    LigandTypeActionAffinityPubmed IDs
    N1-(2-Phenylethyl)-2R)-2-{[4-chorobenzoyl)-hydrazino] carboxamido}3-(1H-3-indolyl)propanamide
    AgonistFull agonist9.2 - 10.212723954
    phenylacetyl-Ala,DTrp-phenthylamide
    AgonistFull agonist7.85 - 8.9219580790 12212809
    bantag-1
    AntagonistAntagonist8.6 - 8.720096642
    [125I][D-Tyr6,beta-Ala11,Phe13,Nle14]bombesin-(6-14)
    AgonistFull agonist8 - 8.49325344
    [D-Phe6,beta-Ala11,Phe13,Nle14]bombesin-(6-14)
    AgonistFull agonist8.05 - 8.389325344
    [D-Tyr6,(R)-APA11,Phe13,Nle14]bombesin-(6-14)
    AgonistFull agonist7.53 - 8.3718006692 20438784
    [D-Tyr6,Apa-4Cl11,Phe13,Nle14]bombesin-(6-14)
    AgonistFull agonist8.115102928
    Bag-1
    AgonistFull agonist7.7420096642
    MK-5046
    AgonistFull agonist7.6--
    Ac-Phe-Trp-Ala-His(tauBZL)-Nip-Gly-Arg-NH2
    AgonistFull agonist6.24 - 7.3118006692 20438784

    4 Novoseek inferred chemical compound relationships for BRS3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ozone 17.3 8 17355223 (6)
    glucose 10.9 2 9367152 (1), 18006692 (1)
    calcium 4.31 1 12212809 (1)
    arginine 0 2 10425452 (1)



    BRS3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for BRS3 gene: 
    NM_001727.1  

    Unigene Cluster for BRS3:

    Bombesin-like receptor 3
    Hs.121484  [show with all ESTs]
    Unigene Representative Sequence: NM_001727
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000370648(uc004ezv.1)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat BRS3
      QuantiFast Probe-based Assays in human, mouse, rat BRS3

    Additional mRNA sequence: 

    AY585193.1 L08893.1 

    1 DOTS entry:

    DT.206356 

    8 AceView cDNA sequences:

    AY585193 NM_001727 L08893 BX104415 BG707051 AW291491 BV198960 AI761066 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BRS3 expression in normal human tissues (normalized intensities)      BRS3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTTCATTT
    BRS3 Expression
    About this image


    BRS3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Neural Tube (Nervous System)
             Metencephalon
    BRS3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BRS3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.121484

    UniProtKB/Swiss-Prot: BRS3_HUMAN, P32247
    Tissue specificity: In germ cells in testis. Lung carcinoma cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BRS3: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat
              Obesity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for BRS3
    OriGene qSTAR qPCR primer pairs in human, mouse for BRS3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BRS3
    QuantiTect SYBR Green Assays in human, mouse, rat BRS3
    QuantiFast Probe-based Assays in human, mouse, rat BRS3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRS3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BRS3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Brs31 , 5 bombesin-like receptor 31, 5 87.35(n)1
    85.43(a)1
      X (30.78 cM)5
    122091  NM_009766.31  NP_033896.21 
     570430745 
    chicken
    (Gallus gallus)
    Aves BRS31 bombesin-like receptor 3 71.2(n)
    70.51(a)
      378927  NM_204406.1  NP_989737.1 
    lizard
    (Anolis carolinensis)
    Reptilia BRS36
    bombesin-like receptor 3
    66(a)
    1 ↔ 1
    AAWZ02037394(164-14027)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004887121 Phe13-bombesin receptor-like 66.58(n)
    65.62(a)
      100488712  XM_002932622.2  XP_002932668.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG301063
    CCHa2r1
    G-protein coupled receptor protein
    signaling pathway more3
    CCHamide-2 receptor1
    37(a)3
    47.73(n)1
    36.09(a)1
      54D33
    355351  NM_136355.41  NP_610199.21 


    ENSEMBL Gene Tree for BRS3 (if available)
    TreeFam Gene Tree for BRS3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BRS3 gene
    EDNRA2  GRPR2  GPR372  EDNRB2  NMBR2  GPR37L12  
    9 SIMAP similar genes for BRS3 using alignment to 1 protein entry:     BRS3_HUMAN:
    GRPR    NMBR    GALR1    GPR83    NPY2R    PRLHR
    NPY6R    NPBWR1    NPBWR2

    BRS3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BRS3 (see all 106)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1860034941,2
    --135568312(+) GAGCCC/GTTTTC 1 -- us2k10--------
    rs1896126561,2
    --135568362(+) TTACTA/GGAGTG 1 -- us2k10--------
    rs1825853551,2
    --135568414(+) TCCCCC/TGCACC 1 -- us2k10--------
    rs1442608241,2
    --135568415(+) CCCCCA/GCACCC 1 -- us2k10--------
    rs12036061,2
    C,F,O,A,H--135568554(+) GAGGTA/CATTGA 1 -- us2k119--NA NS EA WA 2132
    rs2022025361,2
    C--135568630(+) TTGTTA/G/TTTCCC 1 -- us2k10--------
    rs1853120321,2
    --135568959(+) TAAACA/GTCATC 1 -- us2k10--------
    rs1905124381,2
    --135569039(+) AAGTTC/GTTTTG 1 -- us2k10--------
    rs1483942651,2
    --135570095(+) AAGCAG/TGCTGG 1 -- us2k10--------
    rs52311,2
    C,H--135570124(+) GCAAAG/AGAGTA 1 -- us2k1 ese38Minor allele frequency- A:0.01MN NS EA NA 674

    HapMap Linkage Disequilibrium report for BRS3 (135570046 - 135575939 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for BRS3: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BRS3
    DNA2.0 Custom Variant and Variant Library Synthesis for BRS3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300107    OMIM disorders: --

    12 diseases for BRS3:    About MalaCards
    ovarian epithelial cancer    hypertension    lung cancer    pancreatitis
    ovarian cancer    colon adenocarcinoma    obesity    prostate cancer
    prostatitis    colorectal cancer    adenocarcinoma    neuronitis


    BRS3 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for BRS3 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma non-small cell lung 48.1 2 9279210 (1)
    lung carcinoma 33.8 3 8383682 (3)
    nsclc 33.6 7 8959679 (1), 9279210 (1), 9325344 (1), 9593699 (1)
    small cell lung cancer 29.7 3 16979789 (2)
    obesity 29.5 7 10727011 (3), 20347296 (1), 9367152 (1)
    cancer lung 24.5 4 8959679 (1), 16979789 (1), 11166731 (1)
    ovarian carcinoma 17.7 1 10828496 (1)
    colorectal carcinoma 15.5 1 17395367 (1)
    cancer 7.36 1 16979789 (1)
    tumors 1.65 10 10828496 (3), 15634004 (1), 16967266 (1), 18006692 (1) (see all 5)

    Genetic Association Database (GAD): BRS3
    Human Genome Epidemiology (HuGE) Navigator: BRS3 (3 documents)

    Export disorders for BRS3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BRS3 gene, integrated from 10 sources (see all 74):
    (articles sorted by number of sources associating them with BRS3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells. (PubMed id 8383682)1, 2, 3, 9 Fathi Z.... Battey J.F. (J. Biol. Chem. 1993)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    4. Organization and chromosomal localization of the gene for the human bombesin receptor subtype expressed in pregnant uterus. (PubMed id 8131855)1, 2 Gorbulev V.... Fahrenholz F. (FEBS Lett. 1994)
    5. PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells. (PubMed id 17355223)1, 9 Tan Y.R....Weber H.C. (Biochem. J. 2007)
    6. Activation of bombesin receptor subtype-3 stimulates adhesion of lung cancer cells. (PubMed id 16979789)1, 9 Hou X....Tatamoto K. (Lung Cancer 2006)
    7. Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity. (PubMed id 9367152)1, 9 Ohki-Hamazaki H....Wada K. (Nature 1997)
    8. BRS-3 activation transforms the effect of human bronchial epithelial cells from PGE2 mediated inhibition to TGF-beta1 dependent promotion on proliferation and collagen synthesis of lung fibroblasts. (PubMed id 17714959)1, 9 Wang Y....Qin X. (Cell Biol. Int. 2007)
    9. Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3. (PubMed id 9593699)1, 9 Ryan R.R....Jensen R.T. (J. Biol. Chem. 1998)
    10. Bombesin receptor subtype-3 (BRS-3), a novel candidate as therapeutic molecular target in obesity and diabetes. (PubMed id 23291341)1 Ramos-A8lvarez I....GonzA!lez N. (Mol. Cell. Endocrinol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 680 HGNC: 1113 AceView: BRS3 Ensembl:ENSG00000102239 euGenes: HUgn680
    ECgene: BRS3 Kegg: 680 H-InvDB: BRS3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BRS3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for BRS3 gene:
    Search GeneIP for patents involving BRS3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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