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Aliases for BRPF3 Gene

Aliases for BRPF3 Gene

  • Bromodomain And PHD Finger Containing 3 2 3 5
  • Bromodomain And PHD Finger Containing, 3 2
  • KIAA1286 4

External Ids for BRPF3 Gene

Previous GeneCards Identifiers for BRPF3 Gene

  • GC06P036167
  • GC06P036211
  • GC06P036272
  • GC06P035884
  • GC06P036213
  • GC06P036316
  • GC06P037303
  • GC06P036908
  • GC06P036945
  • GC06P037782
  • GC06P038406
  • GC06P038996

Summaries for BRPF3 Gene

GeneCards Summary for BRPF3 Gene

BRPF3 (Bromodomain And PHD Finger Containing 3) is a Protein Coding gene. Among its related pathways are Regulation of TP53 Activity and Response to elevated platelet cytosolic Ca2+. An important paralog of this gene is BRD1.

UniProtKB/Swiss-Prot for BRPF3 Gene

  • Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRPF3 Gene

Genomics for BRPF3 Gene

Regulatory Elements for BRPF3 Gene

Enhancers for BRPF3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G036116 2 FANTOM5 Ensembl ENCODE dbSUPER 13.7 -76.1 -76148 8.0 HDGF PKNOX1 CREB3L1 ARNT SIN3A ZNF2 ZNF766 ZNF143 FOS DEK SLC26A8 ENSG00000272374 PXT1 SRPK1 MAPK14 BRPF3 MAPK13 LOC102723648 STK38 TCP11
GH06G036246 1.4 FANTOM5 Ensembl ENCODE 13.6 +51.3 51318 3.6 CREB3L1 RAD21 ZBTB40 TCF12 GATA2 FOS CREM ZBTB11 CEBPB ZEB2 PXT1 LOC102723648 BRPF3 C6orf222 SLC26A8 MAPK13 MAPK14 SRPK1 KCTD20 STK38
GH06G036094 1.6 Ensembl ENCODE dbSUPER 10.5 -100.6 -100590 3.9 HDGF FOXA2 MLX ARNT ARID4B DMAP1 ZNF2 YY1 SLC30A9 ZNF143 SLC26A8 MAPK13 LOC102723648 BRPF3 FKBP5 ENSG00000232909 ARMC12 SRPK1 TEAD3 ENSG00000237719
GH06G036098 1.5 Ensembl ENCODE dbSUPER 10.8 -96.0 -96023 4.8 HDGF ATF1 PKNOX1 ARNT TCF12 GATA2 JUNB REST ZNF623 ZNF592 SLC26A8 MAPK13 LOC102723648 BRPF3 SRPK1 ARMC12 FKBP5 ENSG00000232909 MAPK14 PIR34765
GH06G036112 1.3 Ensembl ENCODE dbSUPER 11.4 -82.2 -82193 3.2 PKNOX1 CBX3 TBL1XR1 BMI1 RARA ZNF766 CBX5 RELB IKZF2 SP5 SLC26A8 MAPK13 BRPF3 LOC102723648 MAPK14 PIR34765
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BRPF3 on UCSC Golden Path with GeneCards custom track

Promoters for BRPF3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000196173 56 2001 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for BRPF3 Gene

Chromosome:
6
Start:
36,196,744 bp from pter
End:
36,232,790 bp from pter
Size:
36,047 bases
Orientation:
Plus strand

Genomic View for BRPF3 Gene

Genes around BRPF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRPF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRPF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRPF3 Gene

Proteins for BRPF3 Gene

  • Protein details for BRPF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULD4-BRPF3_HUMAN
    Recommended name:
    Bromodomain and PHD finger-containing protein 3
    Protein Accession:
    Q9ULD4
    Secondary Accessions:
    • A6ND56
    • A6NJE2
    • B7ZLN5
    • E7EX85
    • Q17RB6
    • Q5R3K8

    Protein attributes for BRPF3 Gene

    Size:
    1205 amino acids
    Molecular mass:
    135745 Da
    Quaternary structure:
    • Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3.
    SequenceCaution:
    • Sequence=BAA86600.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BRPF3 Gene

    Alternative splice isoforms for BRPF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BRPF3 Gene

Post-translational modifications for BRPF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BRPF3 Gene

Domains & Families for BRPF3 Gene

No data available for UniProtKB/Swiss-Prot for BRPF3 Gene

Function for BRPF3 Gene

Molecular function for BRPF3 Gene

UniProtKB/Swiss-Prot Function:
Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.

Gene Ontology (GO) - Molecular Function for BRPF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17474147
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with BRPF3: view
genes like me logo Genes that share phenotypes with BRPF3: view

Animal Models for BRPF3 Gene

MGI Knock Outs for BRPF3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for BRPF3

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BRPF3 Gene

Localization for BRPF3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BRPF3 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
mitochondrion 2

Gene Ontology (GO) - Cellular Components for BRPF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005829 cytosol TAS --
GO:0070776 MOZ/MORF histone acetyltransferase complex IDA 16387653
genes like me logo Genes that share ontologies with BRPF3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BRPF3 Gene

Pathways & Interactions for BRPF3 Gene

genes like me logo Genes that share pathways with BRPF3: view

Gene Ontology (GO) - Biological Process for BRPF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0016569 covalent chromatin modification IEA --
GO:0043966 histone H3 acetylation IDA 16387653
genes like me logo Genes that share ontologies with BRPF3: view

No data available for SIGNOR curated interactions for BRPF3 Gene

Transcripts for BRPF3 Gene

Unigene Clusters for BRPF3 Gene

Bromodomain and PHD finger containing, 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for BRPF3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BRPF3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14
SP1: -
SP2: - - - -
SP3: -
SP4: -
SP5: -
SP6: -
SP7:

Relevant External Links for BRPF3 Gene

GeneLoc Exon Structure for
BRPF3
ECgene alternative splicing isoforms for
BRPF3

Expression for BRPF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BRPF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BRPF3 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (40.0) and Rectum (28.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BRPF3 Gene



Protein tissue co-expression partners for BRPF3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BRPF3 Gene:

BRPF3

SOURCE GeneReport for Unigene cluster for BRPF3 Gene:

Hs.520096

Evidence on tissue expression from TISSUES for BRPF3 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with BRPF3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BRPF3 Gene

Orthologs for BRPF3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BRPF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BRPF3 34 35
  • 99.53 (n)
dog
(Canis familiaris)
Mammalia BRPF3 34 35
  • 91.92 (n)
cow
(Bos Taurus)
Mammalia BRPF3 34 35
  • 91.12 (n)
mouse
(Mus musculus)
Mammalia Brpf3 34 16 35
  • 87.78 (n)
rat
(Rattus norvegicus)
Mammalia Brpf3 34
  • 87.42 (n)
oppossum
(Monodelphis domestica)
Mammalia BRPF3 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BRPF3 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves BRPF3 34 35
  • 76.2 (n)
lizard
(Anolis carolinensis)
Reptilia BRPF3 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC779492 34
  • 66.74 (n)
zebrafish
(Danio rerio)
Actinopterygii brpf3 34 35
  • 60.26 (n)
BRPF3 (1 of 2) 35
  • 55 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1845 36
  • 42 (a)
Br140 35
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lin-49 36
  • 28 (a)
phf-15 35
  • 21 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NTO1 35
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToMany
Species where no ortholog for BRPF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BRPF3 Gene

ENSEMBL:
Gene Tree for BRPF3 (if available)
TreeFam:
Gene Tree for BRPF3 (if available)

Paralogs for BRPF3 Gene

Variants for BRPF3 Gene

Sequence variations from dbSNP and Humsavar for BRPF3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000004050 -- 36,219,853(+) CTAAC(C/G)CATCC intron-variant
rs1000151670 -- 36,220,575(+) TGATG(G/T)GAACT intron-variant
rs1000156091 -- 36,213,505(+) CCTGG(C/G)CAACA intron-variant
rs1000209649 -- 36,213,820(+) GTATC(C/T)AGCTT intron-variant
rs1000326677 -- 36,231,256(+) TGGTG(-/TC)TCTGC nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for BRPF3 Gene

Variant ID Type Subtype PubMed ID
nsv1073972 CNV deletion 25765185
nsv1133629 CNV deletion 24896259
nsv472104 CNV novel sequence insertion 20440878

Variation tolerance for BRPF3 Gene

Residual Variation Intolerance Score: 2.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.40; 63.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BRPF3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BRPF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRPF3 Gene

Disorders for BRPF3 Gene

Relevant External Links for BRPF3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BRPF3

No disorders were found for BRPF3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BRPF3 Gene

Publications for BRPF3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 64
  2. Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. (PMID: 18794358) Ullah M. … Yang X.-J. (Mol. Cell. Biol. 2008) 3 4 64
  3. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. (PMID: 16387653) Doyon Y. … Cote J. (Mol. Cell 2006) 3 4 64
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for BRPF3 Gene

Sources for BRPF3 Gene

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