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BRPF3 Gene

protein-coding   GIFtS: 53
GCID: GC06P037303

Bromodomain And PHD Finger Containing, 3

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Bromodomain And PHD Finger Containing, 31 2
Bromodomain And PHD Finger-Containing Protein 32
KIAA12863

External Ids:    HGNC: 142561   Entrez Gene: 271542   Ensembl: ENSG000000960707   UniProtKB: Q9ULD43   

Export aliases for BRPF3 gene to outside databases

Previous GC identifers: GC06P036167 GC06P036211 GC06P036272 GC06P035884 GC06P036213 GC06P036316


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for BRPF3 Gene:
BRPF3 (bromodomain and PHD finger containing, 3) is a protein-coding gene. Diseases associated with BRPF3 include leukemia. An important paralog of this gene is JADE2.

UniProtKB/Swiss-Prot: BRPF3_HUMAN, Q9ULD4
Function: Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BRPF3 gene promoter:
         FOXF2   p300   Tal-1beta   GATA-1   E47   MZF-1   PPAR-gamma1   POU2F1   POU2F1a   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBRPF3 promoter sequence
   Search Chromatin IP Primers for BRPF3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BRPF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21.31

BRPF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRPF3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P037303:  view genomic region     (about GC identifiers)

Start:
36,164,521 bp from pter      End:
36,200,567 bp from pter
Size:
36,047 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BRPF3_HUMAN, Q9ULD4 (See protein sequence)
Recommended Name: Bromodomain and PHD finger-containing protein 3  
Size: 1205 amino acids; 135745 Da
Subunit: Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1,
BRD1/BRPF2 and BRPF3
Sequence caution: Sequence=BAA86600.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for BRPF3:
3PFS (3D)    
Secondary accessions: A6NJE2 Q5R3K8

Explore the universe of human proteins at neXtProt for BRPF3: NX_Q9ULD4

Explore proteomics data for BRPF3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BRPF3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056510.2  
    ENSEMBL proteins: 
     ENSP00000350267   ENSP00000345419   ENSP00000434501   ENSP00000416842   ENSP00000410669  
     ENSP00000413655   ENSP00000437087   ENSP00000436504   ENSP00000411558   ENSP00000431894  
     ENSP00000413022   ENSP00000445352   ENSP00000387368  
    Reactome Protein details: Q9ULD4

    BRPF3 Human Recombinant Protein Products:

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    OriGene Custom MassSpec
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    Novus Biologicals BRPF3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BRPF3

    BRPF3 Antibody Products:

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    Abcam antibodies for BRPF3
    Cloud-Clone Corp. Antibodies for BRPF3
    ThermoFisher Antibodies for BRPF3
    LSBio Antibodies in human, mouse, rat for BRPF3

    BRPF3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for BRPF3
    Cloud-Clone Corp. CLIAs for BRPF3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 9):
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR019786 Zinc_finger_PHD-type_CS
     IPR018359 Bromodomain_CS
     IPR001487 Bromodomain

    Graphical View of Domain Structure for InterPro Entry Q9ULD4

    ProtoNet protein and cluster: Q9ULD4

    3 Blocks protein domains:
    IPB000313 PWWP domain
    IPB001487 Bromodomain signature
    IPB001965 Zn-finger-like


    UniProtKB/Swiss-Prot: BRPF3_HUMAN, Q9ULD4
    Similarity: Contains 1 bromo domain
    Similarity: Contains 1 PHD-type zinc finger
    Similarity: Contains 1 PWWP domain


    BRPF3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BRPF3_HUMAN, Q9ULD4
    Function: Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17474147
    GO:0008270zinc ion binding IEA--
         
    BRPF3 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Brpf3):
     mortality/aging 

    BRPF3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BRPF3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BRPF3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BRPF3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BRPF3

    miRNA
    Products:
        
    miRTarBase miRNAs that target BRPF3:
    hsa-let-7b-5p (MIRT051909), hsa-mir-877-3p (MIRT036958), hsa-mir-155-5p (MIRT001563), hsa-mir-1 (MIRT024014)

    Block miRNA regulation of human, mouse, rat BRPF3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BRPF3 (see all 63):
    hsa-miR-142-5p hsa-miR-4328 hsa-miR-513a-5p hsa-miR-218-1* hsa-miR-1245 hsa-miR-128 hsa-miR-16-1* hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmidBRPF3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BRPF3
    Predesigned siRNA for gene silencing in human, mouse, rat BRPF3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BRPF3

    Clone
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    OriGene clones in human, mouse for BRPF3 (see all 6)
    OriGene ORF clones in mouse, rat for BRPF3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BRPF3 (NM_015695)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BRPF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRPF3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for BRPF3
    Browse ESI BIO Cell Lines and PureStem Progenitors for BRPF3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRPF3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    extracellular4
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005829cytosol TAS--
    GO:0070776MOZ/MORF histone acetyltransferase complex IDA16387653

    BRPF3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BRPF3 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    HATs acetylate histones0.34
    Chromatin organization0.34
    Chromatin modifying enzymes0.34
    2Response to elevated platelet cytosolic Ca2+
    Response to elevated platelet cytosolic Ca2+0.94
    Platelet degranulation0.94
    3Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for BRPF3
        HATs acetylate histones
    Platelet degranulation



    BRPF3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including BRPF3: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for BRPF3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BRPF3 (Q9ULD41, 2, 3 ENSP000003502674) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005192, 3, ENSP000003614234MINT-8110083 I2D: score=3 STRING: ENSP00000361423
    FYNP062412, 3, ENSP000003576564MINT-8110983 I2D: score=3 STRING: ENSP00000357656
    PIK3R1P279862, 3, ENSP000002743354MINT-8111739 I2D: score=3 STRING: ENSP00000274335
    NCK1P163331, 3, ENSP000002889864EBI-1753470,EBI-389883 I2D: score=2 STRING: ENSP00000288986
    ING5Q8WYH83, ENSP000003221424I2D: score=1 STRING: ENSP00000322142
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002576platelet degranulation TAS--
    GO:0007596blood coagulation TAS--
    GO:0030168platelet activation TAS--
    GO:0043966histone H3 acetylation IDA16387653

    BRPF3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BRPF3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for BRPF3 gene: 
    NM_015695.2  

    Unigene Cluster for BRPF3:

    Bromodomain and PHD finger containing, 3
    Hs.520096  [show with all ESTs]
    Unigene Representative Sequence: NM_015695
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357641(uc003olv.4 uc010jwb.3 uc011dtj.2 uc010jwc.3 uc011dtk.2 uc010jwd.3)
    ENST00000339717 ENST00000534694 ENST00000449261 ENST00000446974 ENST00000454960
    ENST00000532330 ENST00000534400 ENST00000441123 ENST00000527657 ENST00000532538
    ENST00000441730 ENST00000543502 ENST00000443324
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat BRPF3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BRPF3 (see all 63):
    hsa-miR-142-5p hsa-miR-4328 hsa-miR-513a-5p hsa-miR-218-1* hsa-miR-1245 hsa-miR-128 hsa-miR-16-1* hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmidBRPF3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for BRPF3
    Predesigned siRNA for gene silencing in human, mouse, rat BRPF3
    Clone
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    OriGene clones in human, mouse for BRPF3 (see all 6)
    OriGene ORF clones in mouse, rat for BRPF3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BRPF3 (NM_015695)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BRPF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRPF3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for BRPF3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BRPF3
      QuantiTect SYBR Green Assays in human, mouse, rat BRPF3
      QuantiFast Probe-based Assays in human, mouse, rat BRPF3

    Additional mRNA sequence: 

    AB033112.1 AK000751.1 AK025134.1 AK025224.1 AK074362.1 AK097773.1 AK123574.1 AK172787.1 
    BC033652.2 BC039615.1 BC117387.1 BC143917.1 BC143918.1 BC143919.1 

    9 DOTS entries:

    DT.452215  DT.92011568  DT.91703586  DT.102836443  DT.121376037  DT.121376044  DT.97840963  DT.97840965 
    DT.99952720 

    Selected AceView cDNA sequences (see all 168):

    AA704529 BM055431 BU193199 N74005 BQ233619 BG150257 BP873496 AK123574 
    AI087007 AK172787 BU509365 AI369352 AA868396 CN484908 AB033112 AL602579 
    AA912379 AK025134 BG033814 AK000751 CB147500 AL047079 BQ941673 AI435098 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BRPF3 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14
    SP1:                                                                    -                                                                     
    SP2:                                                                                                              -     -     -     -         
    SP3:                                                                    -                                                                     
    SP4:                                                                                                              -                           
    SP5:                                                                                                              -                           


    ECgene alternative splicing isoforms for BRPF3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BRPF3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGCTCTATT
    BRPF3 Expression
    About this image


    BRPF3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod Long Bone
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             Pelvic Girdle
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
             Meckel's Cartilage
    BRPF3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BRPF3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.520096
        Pathway & Disease-focused RT2 Profiler PCR Array including BRPF3: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for BRPF3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BRPF3
    QuantiTect SYBR Green Assays in human, mouse, rat BRPF3
    QuantiFast Probe-based Assays in human, mouse, rat BRPF3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRPF3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for BRPF3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Brpf31 , 5 bromodomain and PHD finger containing, 31, 5 87.78(n)1
    92.1(a)1
      17 (15.03 cM)5
    2689361  NM_001081315.11  NP_001074784.11 
     288010905 
    chicken
    (Gallus gallus)
    Aves BRPF31 bromodomain and PHD finger containing, 3 76.2(n)
    80.44(a)
      421182  XM_419262.4  XP_419262.3 
    lizard
    (Anolis carolinensis)
    Reptilia BRPF36
    bromodomain and PHD finger containing, 3
    80(a)
    1 ↔ 1
    GL343382.1(542553-586945)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BX750878.12   -- 77.99(n)    BX750878.1 
    zebrafish
    (Danio rerio)
    Actinopterygii brpf31 bromodomain and PHD finger containing, 3 60.26(n)
    58.51(a)
      100149254  XM_005169325.1  XP_005169382.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG18453   -- 42(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea lin-493 zinc-finger protein 28(a)   IV(8620948-8625841)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NTO16
    Subunit of the NuA3 histone acetyltransferase comp...
    26(a)
    1 → many
    XVI(631515-633761) YPR031W


    ENSEMBL Gene Tree for BRPF3 (if available)
    TreeFam Gene Tree for BRPF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BRPF3 gene
    JADE22  BRD12  BRPF12  MLLT102  PHF142  JADE32  JADE12  MLLT62  
    9 SIMAP similar genes for BRPF3 using alignment to 12 protein entries:     BRPF3_HUMAN (see all proteins):
    DKFZp586E1619    DKFZp686F0325    BRPF1    BRD1    DKFZp434B094    AF10
    MLLT10    MLL/AF10 fusion    MLLT6

    BRPF3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BRPF3 (see all 767)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1510879981,2
    C--35882190(+) TAAAAC/TAGCAA 1 -- us2k10--------
    rs1843329791,2
    --35882292(+) TAAGAC/TTCCAT 1 -- us2k10--------
    rs1412812851,2
    --35882309(+) GAACTA/GGTTAC 1 -- us2k10--------
    rs782232401,2
    C,F--35882370(+) GAGGGC/TAACTG 1 -- us2k13Minor allele frequency- T:0.03CSA WA EA 240
    rs1870737311,2
    --35882381(+) TAATGA/GTATCA 1 -- us2k10--------
    rs1469519731,2
    --36162642(+) CACATC/GCATTA 1 -- us2k10--------
    rs1173418831,2
    F--36162684(+) AATCGT/CTGACT 1 -- us2k11Minor allele frequency- C:0.01EA 120
    rs105339291,2
    C--36162814(+) GAAATAA/-AAGTT 1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs1929665471,2
    --36162862(+) TTTTAA/GTAGTT 1 -- us2k10--------
    rs734136881,2
    C--36162866(+) AATAGC/TTTCTG 1 -- us2k11Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for BRPF3 (36164521 - 36200567 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for BRPF3: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BRPF3
    DNA2.0 Custom Variant and Variant Library Synthesis for BRPF3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for BRPF3:    
    About MalaCards
    leukemia


    BRPF3 for disorders           About GeneDecksing


    Export disorders for BRPF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BRPF3 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with BRPF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1999)
    2. Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. (PubMed id 18794358)1, 2 Ullah M....Yang X.-J. (Mol. Cell. Biol. 2008)
    3. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. (PubMed id 16387653)1, 2 Doyon Y.... Cote J. (Mol. Cell 2006)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    6. Structural and histone binding ability characterizations of human PWWP domains. (PubMed id 21720545)2 Wu H.... Min J. (PLoS ONE 2011)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    8. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (Science 2009)
    9. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27154 HGNC: 14256 AceView: BRPF3 Ensembl:ENSG00000096070 euGenes: HUgn27154
    ECgene: BRPF3 H-InvDB: BRPF3

    (According to HUGE)
    About This Section

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    HUGE: KIAA1286

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for BRPF3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for BRPF3 gene:
    Search GeneIP for patents involving BRPF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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