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Aliases for BRPF3 Gene

Aliases for BRPF3 Gene

  • Bromodomain And PHD Finger Containing 3 2 3 5
  • Bromodomain And PHD Finger Containing, 3 2
  • KIAA1286 4

External Ids for BRPF3 Gene

Previous GeneCards Identifiers for BRPF3 Gene

  • GC06P036167
  • GC06P036211
  • GC06P036272
  • GC06P035884
  • GC06P036213
  • GC06P036316
  • GC06P037303
  • GC06P036908
  • GC06P036945

Summaries for BRPF3 Gene

GeneCards Summary for BRPF3 Gene

BRPF3 (Bromodomain And PHD Finger Containing 3) is a Protein Coding gene. Among its related pathways are Chromatin organization and Gene Expression. An important paralog of this gene is BRPF1.

UniProtKB/Swiss-Prot for BRPF3 Gene

  • Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRPF3 Gene

Genomics for BRPF3 Gene

Regulatory Elements for BRPF3 Gene

Enhancers for BRPF3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BRPF3 on UCSC Golden Path with GeneCards custom track

Promoters for BRPF3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BRPF3 on UCSC Golden Path with GeneCards custom track

Genomic Location for BRPF3 Gene

Chromosome:
6
Start:
36,196,744 bp from pter
End:
36,232,790 bp from pter
Size:
36,047 bases
Orientation:
Plus strand

Genomic View for BRPF3 Gene

Genes around BRPF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRPF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRPF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRPF3 Gene

Proteins for BRPF3 Gene

  • Protein details for BRPF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULD4-BRPF3_HUMAN
    Recommended name:
    Bromodomain and PHD finger-containing protein 3
    Protein Accession:
    Q9ULD4
    Secondary Accessions:
    • A6ND56
    • A6NJE2
    • B7ZLN5
    • E7EX85
    • Q17RB6
    • Q5R3K8

    Protein attributes for BRPF3 Gene

    Size:
    1205 amino acids
    Molecular mass:
    135745 Da
    Quaternary structure:
    • Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3.
    SequenceCaution:
    • Sequence=BAA86600.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BRPF3 Gene

    Alternative splice isoforms for BRPF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BRPF3 Gene

Proteomics data for BRPF3 Gene at MOPED

Post-translational modifications for BRPF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for BRPF3 Gene

Domains & Families for BRPF3 Gene

Gene Families for BRPF3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9ULD4

UniProtKB/Swiss-Prot:

BRPF3_HUMAN :
  • Contains 1 bromo domain.
  • Contains 1 PHD-type zinc finger.
Domain:
  • Contains 1 bromo domain.
  • Contains 1 PWWP domain.
Similarity:
  • Contains 1 PHD-type zinc finger.
genes like me logo Genes that share domains with BRPF3: view

Function for BRPF3 Gene

Molecular function for BRPF3 Gene

UniProtKB/Swiss-Prot Function:
Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
genes like me logo Genes that share phenotypes with BRPF3: view

Animal Models for BRPF3 Gene

MGI Knock Outs for BRPF3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BRPF3 Gene

Localization for BRPF3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BRPF3 Gene COMPARTMENTS Subcellular localization image for BRPF3 gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 4
mitochondrion 2

Gene Ontology (GO) - Cellular Components for BRPF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with BRPF3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BRPF3 Gene

Pathways & Interactions for BRPF3 Gene

genes like me logo Genes that share pathways with BRPF3: view

Gene Ontology (GO) - Biological Process for BRPF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007596 blood coagulation TAS --
GO:0030168 platelet activation TAS --
genes like me logo Genes that share ontologies with BRPF3: view

No data available for SIGNOR curated interactions for BRPF3 Gene

Drugs & Compounds for BRPF3 Gene

No Compound Related Data Available

Transcripts for BRPF3 Gene

Unigene Clusters for BRPF3 Gene

Bromodomain and PHD finger containing, 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BRPF3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14
SP1: -
SP2: - - - -
SP3: -
SP4: -
SP5: -
SP6: -
SP7:

Relevant External Links for BRPF3 Gene

GeneLoc Exon Structure for
BRPF3
ECgene alternative splicing isoforms for
BRPF3

Expression for BRPF3 Gene

mRNA expression in normal human tissues for BRPF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BRPF3 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (40.0) and Rectum (28.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BRPF3 Gene



SOURCE GeneReport for Unigene cluster for BRPF3 Gene Hs.520096

genes like me logo Genes that share expression patterns with BRPF3: view

Protein tissue co-expression partners for BRPF3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BRPF3 Gene

Orthologs for BRPF3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BRPF3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BRPF3 35
  • 91.12 (n)
  • 94.44 (a)
BRPF3 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BRPF3 35
  • 91.92 (n)
  • 95.77 (a)
BRPF3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Brpf3 35
  • 87.78 (n)
  • 92.1 (a)
Brpf3 16
Brpf3 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BRPF3 35
  • 99.53 (n)
  • 99.59 (a)
BRPF3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Brpf3 35
  • 87.42 (n)
  • 92.07 (a)
oppossum
(Monodelphis domestica)
Mammalia BRPF3 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BRPF3 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves BRPF3 35
  • 76.2 (n)
  • 80.44 (a)
BRPF3 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BRPF3 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC779492 35
  • 66.74 (n)
  • 70.88 (a)
zebrafish
(Danio rerio)
Actinopterygii brpf3 35
  • 60.26 (n)
  • 58.51 (a)
brpf3 36
  • 60 (a)
OneToMany
BRPF3 (1 of 2) 36
  • 55 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1845 37
  • 42 (a)
Br140 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lin-49 37
  • 28 (a)
phf-15 36
  • 21 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NTO1 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for BRPF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BRPF3 Gene

ENSEMBL:
Gene Tree for BRPF3 (if available)
TreeFam:
Gene Tree for BRPF3 (if available)

Paralogs for BRPF3 Gene

Paralogs for BRPF3 Gene

genes like me logo Genes that share paralogs with BRPF3: view

Variants for BRPF3 Gene

Sequence variations from dbSNP and Humsavar for BRPF3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs17658935 - 36,201,155(+) TGGCG(C/G)CTTCA nc-transcript-variant, reference, missense
rs45504893 - 36,200,851(+) GGCAC(A/G)GTTTG nc-transcript-variant, reference, missense
rs6457892 -- 36,216,075(+) CTGGA(G/T)TTAGG intron-variant
rs6457894 -- 36,220,803(+) ACTAC(A/T)GGTTA intron-variant
rs6906000 -- 36,222,340(+) CACTG(C/T)TGGGG intron-variant

Variation tolerance for BRPF3 Gene

Residual Variation Intolerance Score: 2.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.40; 63.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BRPF3 Gene

HapMap Linkage Disequilibrium report
BRPF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BRPF3 Gene

Disorders for BRPF3 Gene

Relevant External Links for BRPF3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BRPF3

No disorders were found for BRPF3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BRPF3 Gene

Publications for BRPF3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  4. Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. (PMID: 18794358) Ullah M. … Yang X.-J. (Mol. Cell. Biol. 2008) 3
  5. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PMID: 17474147) Wu C. … Li S.S. (Proteomics 2007) 3

Products for BRPF3 Gene

Sources for BRPF3 Gene

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