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Aliases for BRPF3 Gene

Aliases for BRPF3 Gene

  • Bromodomain And PHD Finger Containing, 3 2 3
  • KIAA1286 4

External Ids for BRPF3 Gene

Previous GeneCards Identifiers for BRPF3 Gene

  • GC06P036167
  • GC06P036211
  • GC06P036272
  • GC06P035884
  • GC06P036213
  • GC06P036316
  • GC06P037303

Summaries for BRPF3 Gene

GeneCards Summary for BRPF3 Gene

BRPF3 (Bromodomain And PHD Finger Containing, 3) is a Protein Coding gene. Among its related pathways are Hemostasis and Hemostasis. An important paralog of this gene is PHF14.

UniProtKB/Swiss-Prot for BRPF3 Gene

  • Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRPF3 Gene

Genomics for BRPF3 Gene

Regulatory Elements for BRPF3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BRPF3 Gene

36,196,631 bp from pter
36,232,790 bp from pter
36,160 bases
Plus strand

Genomic View for BRPF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BRPF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRPF3 Gene

Proteins for BRPF3 Gene

  • Protein details for BRPF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Bromodomain and PHD finger-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • A6ND56
    • A6NJE2
    • B7ZLN5
    • E7EX85
    • Q17RB6
    • Q5R3K8

    Protein attributes for BRPF3 Gene

    1205 amino acids
    Molecular mass:
    135745 Da
    Quaternary structure:
    • Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3.
    • Sequence=BAA86600.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BRPF3 Gene

    Alternative splice isoforms for BRPF3 Gene


neXtProt entry for BRPF3 Gene

Proteomics data for BRPF3 Gene at MOPED

Post-translational modifications for BRPF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BRPF3 Gene

Domains for BRPF3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9ULD4
  • Contains 1 bromo domain.
  • Contains 1 PWWP domain.
  • Contains 1 PHD-type zinc finger.
genes like me logo Genes that share domains with BRPF3: view

No data available for Gene Families for BRPF3 Gene

Function for BRPF3 Gene

Molecular function for BRPF3 Gene

UniProtKB/Swiss-Prot Function: Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.

Gene Ontology (GO) - Molecular Function for BRPF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17474147
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with BRPF3: view

Phenotypes for BRPF3 Gene

MGI mutant phenotypes for BRPF3:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with BRPF3: view

Animal Model Products

CRISPR Products

miRNA for BRPF3 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BRPF3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for BRPF3 Gene

Localization for BRPF3 Gene

Subcellular locations from

Jensen Localization Image for BRPF3 Gene COMPARTMENTS Subcellular localization image for BRPF3 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for BRPF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005829 cytosol TAS --
GO:0070776 MOZ/MORF histone acetyltransferase complex IDA 16387653
genes like me logo Genes that share ontologies with BRPF3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BRPF3 Gene

Pathways for BRPF3 Gene

genes like me logo Genes that share pathways with BRPF3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for BRPF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0007596 blood coagulation TAS --
GO:0030168 platelet activation TAS --
GO:0043966 histone H3 acetylation IDA 16387653
genes like me logo Genes that share ontologies with BRPF3: view

Transcripts for BRPF3 Gene

Unigene Clusters for BRPF3 Gene

Bromodomain and PHD finger containing, 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BRPF3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for BRPF3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BRPF3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14
SP1: -
SP2: - - - -
SP3: -
SP4: -
SP5: -
SP6: -

Relevant External Links for BRPF3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BRPF3 Gene

mRNA expression in normal human tissues for BRPF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BRPF3 Gene

SOURCE GeneReport for Unigene cluster for BRPF3 Gene Hs.520096

genes like me logo Genes that share expressions with BRPF3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BRPF3 Gene

Orthologs for BRPF3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BRPF3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BRPF3 35
  • 99.53 (n)
  • 99.59 (a)
BRPF3 36
  • 100 (a)
(Bos Taurus)
Mammalia BRPF3 35
  • 91.12 (n)
  • 94.44 (a)
BRPF3 36
  • 94 (a)
(Canis familiaris)
Mammalia BRPF3 35
  • 91.92 (n)
  • 95.77 (a)
BRPF3 36
  • 95 (a)
(Mus musculus)
Mammalia Brpf3 35
  • 87.78 (n)
  • 92.1 (a)
Brpf3 16
Brpf3 36
  • 92 (a)
(Monodelphis domestica)
Mammalia BRPF3 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia BRPF3 36
  • 81 (a)
(Rattus norvegicus)
Mammalia Brpf3 35
  • 87.42 (n)
  • 92.07 (a)
(Gallus gallus)
Aves BRPF3 35
  • 76.2 (n)
  • 80.44 (a)
BRPF3 36
  • 77 (a)
(Anolis carolinensis)
Reptilia BRPF3 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC779492 35
  • 66.74 (n)
  • 70.88 (a)
(Danio rerio)
Actinopterygii brpf3 35
  • 60.26 (n)
  • 58.51 (a)
brpf3 36
  • 60 (a)
BRPF3 (1 of 2) 36
  • 55 (a)
fruit fly
(Drosophila melanogaster)
Insecta Br140 36
  • 31 (a)
CG1845 37
  • 42 (a)
(Caenorhabditis elegans)
Secernentea phf-15 36
  • 21 (a)
lin-49 37
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NTO1 36
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
Species with no ortholog for BRPF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BRPF3 Gene

Gene Tree for BRPF3 (if available)
Gene Tree for BRPF3 (if available)

Paralogs for BRPF3 Gene

Paralogs for BRPF3 Gene

genes like me logo Genes that share paralogs with BRPF3: view

Variants for BRPF3 Gene

Sequence variations from dbSNP and Humsavar for BRPF3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs13214 -- 36,212,280(+) CATAC(C/T)TGCCT intron-variant
rs2032506 -- 36,224,449(-) CCTGG(A/G)GCAGG intron-variant
rs2157317 -- 36,222,379(-) AGTTT(C/G)GGGGA intron-variant
rs2239798 -- 36,210,080(-) GGCCC(A/G)CCCTG intron-variant
rs2245972 -- 36,204,597(-) AGCCT(A/G)TGCAT intron-variant

Relevant External Links for BRPF3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BRPF3 Gene

Disorders for BRPF3 Gene

No disorders were found for BRPF3 Gene.

No data available for UniProtKB/Swiss-Prot for BRPF3 Gene

Publications for BRPF3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. (PMID: 16387653) Doyon Y. … Cote J. (Mol. Cell 2006) 3 4
  4. Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. (PMID: 18794358) Ullah M. … Yang X.-J. (Mol. Cell. Biol. 2008) 3 4
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for BRPF3 Gene

  • Addgene plasmids for BRPF3

Sources for BRPF3 Gene

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