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BRPF1 Gene

protein-coding   GIFtS: 59
GCID: GC03P009783

Bromodomain And PHD Finger Containing, 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Bromodomain And PHD Finger Containing, 11 2     140kD1
BR1402 3 5     Bromodomain-Containing Protein1
peregrin1 2     Bromodomain-Containing Protein, 140kD2
Bromodomain And PHD Finger-Containing Protein 12 3     Protein Br1403

External Ids:    HGNC: 142551   Entrez Gene: 78622   Ensembl: ENSG000001569837   OMIM: 6024105   UniProtKB: P552013   

Export aliases for BRPF1 gene to outside databases

Previous GC identifers: GC03P009702 GC03P009765 GC03P009748 GC03P009709 GC03P009776 GC03P009777 GC03P009778 GC03P009779 GC03P009780 GC03P009781


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BRPF1 Gene:
The protein encoded by this gene is expressed ubiquitously and at the highest level in testes and spermatogonia.
The protein is localized within nuclei, and it is very similar in structure to two zinc finger proteins, AF10 and
AF17. It is suggested that these proteins form a family of regulatory proteins. Two alternatively spliced
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for BRPF1 Gene:
BRPF1 (bromodomain and PHD finger containing, 1) is a protein-coding gene. An important paralog of this gene is JADE2.

UniProtKB/Swiss-Prot: BRPF1_HUMAN, P55201
Function: Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively
regulates the transcription of RUNX1 and RUNX2




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BRPF1 gene promoter:
         PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBRPF1 promoter sequence
   Search Chromatin IP Primers for BRPF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BRPF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p26-p25   Ensembl cytogenetic band:  3p25.3   HGNC cytogenetic band: 3p26-p25

BRPF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRPF1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P009783:  view genomic region     (about GC identifiers)

Start:
9,773,413 bp from pter      End:
9,789,702 bp from pter
Size:
16,290 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: BRPF1_HUMAN, P55201 (See protein sequence)
Recommended Name: Peregrin  
Size: 1214 amino acids; 137499 Da
Subunit: Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1,
BRD1/BRPF2 and BRPF3. Interacts with trimethylated 'Lys-36' of histone H3 (H3K36me3)
Selected PDB 3D structures from and Proteopedia for BRPF1 (see all 9):
2D9E (3D)        2RS9 (3D)        2X35 (3D)        2X4W (3D)        2X4X (3D)        2X4Y (3D)    
Secondary accessions: B4DEZ6 Q7Z6E0 Q8TCM6 Q9UHI0
Alternative splicing: 4 isoforms:  P55201-1   P55201-2   P55201-3   P55201-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BRPF1: NX_P55201

Explore proteomics data for BRPF1 at MOPED

Post-translational modifications: 

  • Acetylated by KAT6A1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BRPF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001003694.1  NP_004625.2  

    ENSEMBL proteins: 
     ENSP00000402485   ENSP00000398863   ENSP00000373340   ENSP00000416728   ENSP00000404235  
     ENSP00000410210   ENSP00000306297  
    Reactome Protein details: P55201

    BRPF1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for BRPF1

     
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    antibodies-online proteins for BRPF1 (2 products) 

     
    antibodies-online peptides for BRPF1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 11):
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR015880 Znf_C2H2-like
     IPR019786 Zinc_finger_PHD-type_CS
     IPR018359 Bromodomain_CS

    Graphical View of Domain Structure for InterPro Entry P55201

    ProtoNet protein and cluster: P55201

    3 Blocks protein domains:
    IPB000313 PWWP domain
    IPB001487 Bromodomain signature
    IPB001965 Zn-finger-like


    UniProtKB/Swiss-Prot: BRPF1_HUMAN, P55201
    Similarity: Contains 1 bromo domain
    Similarity: Contains 1 C2H2-type zinc finger
    Similarity: Contains 1 PHD-type zinc finger
    Similarity: Contains 1 PWWP domain


    Find genes that share domains with BRPF1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BRPF1_HUMAN, P55201
    Function: Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively
    regulates the transcription of RUNX1 and RUNX2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with BRPF1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for BRPF1:
     Decreased influenza A/WSN/33 r 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Brpf1):
     behavior/neurological  growth/size/body  homeostasis/metabolism  other  skeleton 

    Find genes that share phenotypes with BRPF1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for BRPF1

    miRNA
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    miRTarBase miRNAs that target BRPF1:
    hsa-mir-183-5p (MIRT047074), hsa-mir-17-3p (MIRT050786), hsa-let-7b-5p (MIRT052041), hsa-mir-331-3p (MIRT043564)

    Block miRNA regulation of human, mouse, rat BRPF1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BRPF1 (see all 35):
    hsa-miR-3678-3p hsa-miR-193a-3p hsa-let-7a-2* hsa-miR-624* hsa-miR-488 hsa-miR-4267 hsa-miR-193b hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmidBRPF1 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for BRPF1 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BRPF1_HUMAN, P55201: Nucleus. Cytoplasm. Note=Localization to the nucleus depends on KAT6A, ING5 and MEAF6
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane4
    cytosol3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18794358
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane ----
    GO:0070776MOZ/MORF histone acetyltransferase complex IDA16387653

    Find genes that share ontologies with BRPF1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BRPF1 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    HATs acetylate histones0.34
    Chromatin organization0.34
    Chromatin modifying enzymes0.34


    Find genes that share SuperPaths with BRPF1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for BRPF1
        HATs acetylate histones


        Pathway & Disease-focused RT2 Profiler PCR Array including BRPF1: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for BRPF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BRPF1 (P552013 ENSP000003733404) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GTF2H1P327803, ENSP000002659634I2D: score=1 STRING: ENSP00000265963
    MEAF6Q9HAF13, ENSP000003621664I2D: score=1 STRING: ENSP00000362166
    KAT6AQ927943, ENSP000002657134I2D: score=1 STRING: ENSP00000265713
    ING5Q8WYH83, ENSP000003221424I2D: score=1 STRING: ENSP00000322142
    PBXIP1Q96AQ63, ENSP000003574484I2D: score=1 STRING: ENSP00000357448
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006325chromatin organization TAS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0043966histone H3 acetylation IDA16387653
    GO:0045893positive regulation of transcription, DNA-templated IDA18794358

    Find genes that share ontologies with BRPF1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BRPF1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BRPF1 gene (2 alternative transcripts): 
    NM_001003694.1  NM_004634.2  

    Unigene Cluster for BRPF1:

    Bromodomain and PHD finger containing, 1
    Hs.1004  [show with all ESTs]
    Unigene Representative Sequence: NM_001003694
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000433861 ENST00000424362(uc003bsg.3) ENST00000383829(uc003bsf.3)
    ENST00000420291 ENST00000426583 ENST00000457855 ENST00000469066 ENST00000497565
    ENST00000302054(uc003bse.3 uc011ati.2)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate BRPF1 (see all 35):
    hsa-miR-3678-3p hsa-miR-193a-3p hsa-let-7a-2* hsa-miR-624* hsa-miR-488 hsa-miR-4267 hsa-miR-193b hsa-miR-4324
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      QuantiTect SYBR Green Assays in human, mouse, rat BRPF1
      QuantiFast Probe-based Assays in human, mouse, rat BRPF1

    Additional mRNA sequence: 

    AK293865.1 AL713696.1 BC036374.1 BC053851.1 BC068262.1 M91585.1 

    5 DOTS entries:

    DT.452250  DT.101981514  DT.91750552  DT.100751601  DT.91750556 

    Selected AceView cDNA sequences (see all 121):

    BQ677528 BU172656 BG763275 AI949522 BE551296 CB242714 CD367340 CA435918 
    BQ027226 NM_004634 AI356310 AI825087 AA058805 AI982517 BQ897562 BQ682102 
    AL713696 BU167250 AI056827 T28235 NM_001003694 AA317581 CA435969 AI696205 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BRPF1 (see all 27)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                    -           -                                   -                                                                                       
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 14 ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17a · 17b · 17c · 17d ^ 18 ^ 19a · 19b · 19c · 19d · 19e ^ 20a · 20b · 20c ^ 21 ^ 22a · 22b · 22c · 22d ^ 23 ^
    SP1:  -                 -     -     -           -     -                       -                                               -                                 
    SP2:  -     -     -     -     -     -     -     -     -     -     -     -     -                                               -                             -   
    SP3:                                                                                                                                                            
    SP4:                                                                          -                                               -                                 
    SP5:                                                                          -                                               -                             -   

    ExUns: 24 ^ 25 ^ 26a · 26b · 26c · 26d
    SP1:  -                                 
    SP2:  -                                 
    SP3:                                    
    SP4:  -                                 
    SP5:  -                                 


    ECgene alternative splicing isoforms for BRPF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BRPF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAGGAGAAT
    BRPF1 Expression
    About this image


    BRPF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
    BRPF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BRPF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1004

    UniProtKB/Swiss-Prot: BRPF1_HUMAN, P55201
    Tissue specificity: High levels in testis

        Pathway & Disease-focused RT2 Profiler PCR Array including BRPF1: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRPF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for BRPF1 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Brpf11 , 5 bromodomain and PHD finger containing, 11, 5 91.87(n)1
    98.27(a)1
      6 (52.75 cM)5
    787831  NM_001282126.11  NP_001269055.11 
     1133071815 
    chicken
    (Gallus gallus)
    Aves BRPF11 bromodomain and PHD finger containing, 1 81.64(n)
    91.98(a)
      427590  NM_001031464.1  NP_001026635.1 
    lizard
    (Anolis carolinensis)
    Reptilia BRPF16
    bromodomain and PHD finger containing, 1
    90(a)
    1 ↔ 1
    2(191129089-191167023)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX851330.12   -- 77.33(n)    BX851330.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc555302 similar to bromodomain and PHD finger containing, 1 78.8(n)   393991  BC044418.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG18453
    Br1401
    Br1401 44(a)3
    57.51(n)1
    51.42(a)1
      356481  NM_136422.31  NP_610266.11 
    worm
    (Caenorhabditis elegans)
    Secernentea lin-493 zinc-finger protein 30(a)   IV(8620948-8625841)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NTO1(YPR031W)4 Subunit of the NuA3 histone acetyltransferase complex more   --   16(631515-633761) 856143  NP_015356.1 


    ENSEMBL Gene Tree for BRPF1 (if available)
    TreeFam Gene Tree for BRPF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BRPF1 gene
    JADE22  BRD12  MLLT102  PHF142  JADE32  JADE12  MLLT62  BRPF32  
    3 SIMAP similar genes for BRPF1 using alignment to 3 protein entries:     BRPF1_HUMAN (see all proteins):
    BRPF3    BRD1    DKFZp434B094

    Find genes that share paralogs with BRPF1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BRPF1 (see all 439)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1395730761,2
    --9772093(+) TCTGAA/GAAGAT 2 -- us2k10--------
    rs1427993941,2
    --9772101(+) GATGAA/GTCATT 2 -- us2k10--------
    rs1472844421,2
    --9772112(+) TAAGAG/TAATTC 2 -- us2k10--------
    rs1407915101,2
    --9772212(+) TTTTAG/TTGGGT 2 -- us2k10--------
    rs1446523111,2
    --9772312(+) TGATGA/GCAAAA 2 -- us2k10--------
    rs1457170011,2
    --9772709(+) TTCCCC/TACAGC 2 -- us2k10--------
    rs1890835271,2
    --9772787(+) TTTATG/TTCTAG 2 -- us2k10--------
    rs1815976191,2
    --9772815(+) GGCTCA/GTCCAA 2 -- us2k10--------
    rs1591451,2
    C,F,A,H--9772839(-) ACTCGG/CGAGAG 2 -- us2k119Minor allele frequency- C:0.25EA MN NS NA WA CSA 2361
    rs1485005951,2
    C--9772946(+) ACCGGC/TCTAGT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for BRPF1 (9773413 - 9789702 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for BRPF1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BRPF1
    DNA2.0 Custom Variant and Variant Library Synthesis for BRPF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602410    OMIM disorders: --


    Find genes that share disorders with BRPF1           About GenesLikeMe

    Genetic Association Database (GAD): BRPF1
    Human Genome Epidemiology (HuGE) Navigator: BRPF1 (7 documents)

    Export disorders for BRPF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BRPF1 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with BRPF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. BR140, a novel zinc-finger protein with homology to the TAF250 subunit of TFIID. (PubMed id 7906940)1, 2, 3 Thompson K.A....Ruoslahti E. (Biochem. Biophys. Res. Commun. 1994)
    2. Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1. (PubMed id 20400950)1, 2, 9 Vezzoli A.... Bycroft M. (Nat. Struct. Mol. Biol. 2010)
    3. Structural and histone binding ability characterizations of human PWWP domains. (PubMed id 21720545)1, 2 Wu H.... Min J. (PLoS ONE 2011)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. (PubMed id 18794358)1, 2 Ullah M....Yang X.-J. (Mol. Cell. Biol. 2008)
    6. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. (PubMed id 16387653)1, 2 Doyon Y.... Cote J. (Mol. Cell 2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    8. Gene BR140, which is related to AF10 and AF17, maps to chromosome band 3p25. (PubMed id 8946209)1, 3 Gregorini A....Young B.D. (amp 1996)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7862 HGNC: 14255 AceView: LOC151835 Ensembl:ENSG00000156983 euGenes: HUgn7862
    ECgene: BRPF1 H-InvDB: BRPF1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BRPF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BRPF1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BRPF1 gene:
    Search GeneIP for patents involving BRPF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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