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Aliases for BRPF1 Gene

Aliases for BRPF1 Gene

  • Bromodomain And PHD Finger Containing, 1 2 3
  • BR140 3 4 6
  • Bromodomain And PHD Finger-Containing Protein 1 3 4
  • Peregrin 2 3
  • Bromodomain-Containing Protein, 140kD 3
  • Bromodomain-Containing Protein 2
  • Protein Br140 4
  • 140kD 2

External Ids for BRPF1 Gene

Summaries for BRPF1 Gene

Entrez Gene Summary for BRPF1 Gene

  • The protein encoded by this gene is expressed ubiquitously and at the highest level in testes and spermatogonia. The protein is localized within nuclei, and it is very similar in structure to two zinc finger proteins, AF10 and AF17. It is suggested that these proteins form a family of regulatory proteins. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for BRPF1 Gene

BRPF1 (Bromodomain And PHD Finger Containing, 1) is a Protein Coding gene. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening. An important paralog of this gene is PHF14.

UniProtKB/Swiss-Prot for BRPF1 Gene

  • Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRPF1 Gene

Genomics for BRPF1 Gene

Genomic Location for BRPF1 Gene

Start:
9,731,729 bp from pter
End:
9,748,018 bp from pter
Size:
16,290 bases
Orientation:
Plus strand

Genomic View for BRPF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BRPF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRPF1 Gene

Regulatory Elements for BRPF1 Gene

Proteins for BRPF1 Gene

  • Protein details for BRPF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55201-BRPF1_HUMAN
    Recommended name:
    Peregrin
    Protein Accession:
    P55201
    Secondary Accessions:
    • B4DEZ6
    • Q7Z6E0
    • Q8TCM6
    • Q9UHI0

    Protein attributes for BRPF1 Gene

    Size:
    1214 amino acids
    Molecular mass:
    137499 Da
    Quaternary structure:
    • Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. Interacts with trimethylated Lys-36 of histone H3 (H3K36me3).

    Three dimensional structures from OCA and Proteopedia for BRPF1 Gene

    Alternative splice isoforms for BRPF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BRPF1 Gene

Proteomics data for BRPF1 Gene at MOPED

Post-translational modifications for BRPF1 Gene

Other Protein References for BRPF1 Gene

No data available for DME Specific Peptides for BRPF1 Gene

Domains for BRPF1 Gene

UniProtKB/Swiss-Prot:

BRPF1_HUMAN
Domain:
  • Contains 1 bromo domain.:
    • P55201
  • Contains 1 PWWP domain.:
    • P55201
Similarity:
  • Contains 1 C2H2-type zinc finger.:
    • P55201
  • Contains 1 PHD-type zinc finger.:
    • P55201
genes like me logo Genes that share domains with BRPF1: view

No data available for Gene Families for BRPF1 Gene

Function for BRPF1 Gene

Molecular function for BRPF1 Gene

UniProtKB/Swiss-Prot Function: Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.

Gene Ontology (GO) - Molecular Function for BRPF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25281266
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with BRPF1: view
genes like me logo Genes that share phenotypes with BRPF1: view

miRNA for BRPF1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for BRPF1 Gene

Localization for BRPF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRPF1 Gene

Nucleus. Cytoplasm. Note=Localization to the nucleus depends on KAT6A, ING5 and MEAF6.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BRPF1 Gene COMPARTMENTS Subcellular localization image for BRPF1 gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 3

Gene Ontology (GO) - Cellular Components for BRPF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18794358
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0070776 MOZ/MORF histone acetyltransferase complex IDA 16387653
genes like me logo Genes that share ontologies with BRPF1: view

Pathways for BRPF1 Gene

genes like me logo Genes that share pathways with BRPF1: view

Pathways by source for BRPF1 Gene

Gene Ontology (GO) - Biological Process for BRPF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0043966 histone H3 acetylation IDA 16387653
GO:0045893 positive regulation of transcription, DNA-templated IDA 18794358
genes like me logo Genes that share ontologies with BRPF1: view

Transcripts for BRPF1 Gene

Unigene Clusters for BRPF1 Gene

Bromodomain and PHD finger containing, 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BRPF1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d · 8e ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^
SP1:
SP2:
SP3: - - -
SP4:
SP5:
SP6: - - - -
SP7: - - -
SP8: - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: -
SP15: - - -
SP16: -
SP17:
SP18: - - - - -
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:

ExUns: 14 ^ 15a · 15b · 15c ^ 16a · 16b · 16c ^ 17a · 17b · 17c · 17d ^ 18 ^ 19a · 19b · 19c · 19d · 19e ^ 20a · 20b · 20c ^ 21 ^ 22a · 22b · 22c · 22d ^ 23 ^
SP1: - - - - - - - -
SP2: - - - - - - - - - - - - - - -
SP3:
SP4: - -
SP5: - - -
SP6:
SP7:
SP8:
SP9: -
SP10: - - - - - - -
SP11: - - - - -
SP12: - - - - - - - - -
SP13: - - -
SP14:
SP15:
SP16:
SP17: -
SP18:
SP19:
SP20: - - - - - - - - - - - - - - - - - -
SP21: - - - - - -
SP22: - - -
SP23: - - -
SP24: - -
SP25:
SP26:
SP27: -

ExUns: 24 ^ 25 ^ 26a · 26b · 26c · 26d
SP1: -
SP2: -
SP3:
SP4: -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27: - -

Relevant External Links for BRPF1 Gene

GeneLoc Exon Structure for
BRPF1
ECgene alternative splicing isoforms for
BRPF1

Expression for BRPF1 Gene

mRNA expression in normal human tissues for BRPF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BRPF1 Gene

SOURCE GeneReport for Unigene cluster for BRPF1 Gene Hs.1004

mRNA Expression by UniProt/SwissProt for BRPF1 Gene

P55201-BRPF1_HUMAN
Tissue specificity: High levels in testis
genes like me logo Genes that share expressions with BRPF1: view

Orthologs for BRPF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BRPF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BRPF1 36
  • 99.73 (n)
  • 99.84 (a)
BRPF1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BRPF1 36
  • 93.11 (n)
  • 98.93 (a)
BRPF1 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BRPF1 36
  • 93.99 (n)
  • 99.18 (a)
BRPF1 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Brpf1 36
  • 91.87 (n)
  • 98.27 (a)
Brpf1 16
Brpf1 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BRPF1 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BRPF1 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Brpf1 36
  • 91.78 (n)
  • 98.35 (a)
chicken
(Gallus gallus)
Aves BRPF1 36
  • 81.64 (n)
  • 91.98 (a)
BRPF1 37
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BRPF1 37
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia brpf1 36
  • 73.31 (n)
  • 80.29 (a)
zebrafish
(Danio rerio)
Actinopterygii brpf1 36
  • 72.35 (n)
  • 76.78 (a)
BRPF1 37
  • 62 (a)
OneToOne
zgc55530 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007617 36
  • 56.46 (n)
  • 52 (a)
fruit fly
(Drosophila melanogaster)
Insecta Br140 36
  • 57.51 (n)
  • 51.42 (a)
Br140 37
  • 35 (a)
OneToMany
CG1845 38
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea lin-49 37
  • 23 (a)
ManyToMany
lin-49 38
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NTO1 37
  • 25 (a)
OneToMany
NTO1 39
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2273 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 43 (a)
OneToMany
Species with no ortholog for BRPF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BRPF1 Gene

ENSEMBL:
Gene Tree for BRPF1 (if available)
TreeFam:
Gene Tree for BRPF1 (if available)

Paralogs for BRPF1 Gene

Paralogs for BRPF1 Gene

Selected SIMAP similar genes for BRPF1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BRPF1: view

Variants for BRPF1 Gene

Sequence variations from dbSNP and Humsavar for BRPF1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs11632 -- 9,747,658(+) GCCAT(C/G)CCACC utr-variant-3-prime
rs159145 -- 9,731,155(-) ACTCG(C/G)GAGAG upstream-variant-2KB
rs159146 -- 9,733,476(-) TCCCC(C/T)CTGGA intron-variant
rs159154 -- 9,741,676(-) CACAC(A/G)CTATT intron-variant
rs159155 -- 9,738,171(-) TCACT(C/T)ACTAT intron-variant

Relevant External Links for BRPF1 Gene

HapMap Linkage Disequilibrium report
BRPF1

No data available for Structural Variations from Database of Genomic Variants (DGV) for BRPF1 Gene

Disorders for BRPF1 Gene

Relevant External Links for BRPF1

Genetic Association Database (GAD)
BRPF1
Human Genome Epidemiology (HuGE) Navigator
BRPF1
genes like me logo Genes that share disorders with BRPF1: view

No data available for UniProtKB/Swiss-Prot for BRPF1 Gene

Publications for BRPF1 Gene

  1. Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1. (PMID: 20400950) Vezzoli A. … Bycroft M. (Nat. Struct. Mol. Biol. 2010) 3 4 23
  2. BR140, a novel zinc-finger protein with homology to the TAF250 subunit of TFIID. (PMID: 7906940) Thompson K.A. … Ruoslahti E. (Biochem. Biophys. Res. Commun. 1994) 2 3 4
  3. Gene BR140, which is related to AF10 and AF17, maps to chromosome band 3p25. (PMID: 8946209) Gregorini A. … Young B.D. (Genes Chromosomes Cancer 1996) 2 3
  4. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. (PMID: 16387653) Doyon Y. … Cote J. (Mol. Cell 2006) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for BRPF1 Gene

  • Addgene plasmids for BRPF1

Sources for BRPF1 Gene

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