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Aliases for BROX Gene

Aliases for BROX Gene

  • BRO1 Domain And CAAX Motif Containing 2 3
  • C1orf58 3 4
  • BRO1 Domain- And CAAX Motif-Containing Protein 4
  • BRO1 Domain-Containing Protein BROX 3
  • Chromosome 1 Open Reading Frame 58 2
  • BRO1 Domain Containing Protein 2
  • BROFTI 4

External Ids for BROX Gene

Previous HGNC Symbols for BROX Gene

  • C1orf58

Previous GeneCards Identifiers for BROX Gene

  • GC01P222886

Summaries for BROX Gene

GeneCards Summary for BROX Gene

BROX (BRO1 Domain And CAAX Motif Containing) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BROX Gene

Genomics for BROX Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BROX Gene

222,712,553 bp from pter
222,735,196 bp from pter
22,644 bases
Plus strand

Genomic View for BROX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BROX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BROX Gene

No data available for Regulatory Elements for BROX Gene

Proteins for BROX Gene

  • Protein details for BROX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BRO1 domain-containing protein BROX
    Protein Accession:
    Secondary Accessions:
    • B7Z9G5
    • Q96MG1

    Protein attributes for BROX Gene

    411 amino acids
    Molecular mass:
    46476 Da
    Quaternary structure:
    • Interacts with CHMP4B.

    Three dimensional structures from OCA and Proteopedia for BROX Gene

    Alternative splice isoforms for BROX Gene


neXtProt entry for BROX Gene

Proteomics data for BROX Gene at MOPED

Post-translational modifications for BROX Gene

  • Ubiquitination at Lys155 and Lys334
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BROX Gene

Domains for BROX Gene

Protein Domains for BROX Gene


Suggested Antigen Peptide Sequences for BROX Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BRO1 domain.
  • Belongs to the BROX family.
  • Contains 1 BRO1 domain.
  • Belongs to the BROX family.
genes like me logo Genes that share domains with BROX: view

No data available for Gene Families for BROX Gene

Function for BROX Gene

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BROX

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BROX Gene

Localization for BROX Gene

Subcellular locations from UniProtKB/Swiss-Prot for BROX Gene

Membrane; Lipid-anchor.

Gene Ontology (GO) - Cellular Components for BROX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with BROX: view

No data available for Subcellular locations from COMPARTMENTS for BROX Gene

Pathways for BROX Gene

SuperPathways for BROX Gene

No Data Available

Interacting Proteins for BROX Gene

Gene Ontology (GO) - Biological Process for BROX Gene


No data available for Pathways by source for BROX Gene

Transcripts for BROX Gene

Unigene Clusters for BROX Gene

BRO1 domain and CAAX motif containing:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BROX

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BROX Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - -

Relevant External Links for BROX Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BROX Gene

mRNA expression in normal human tissues for BROX Gene

Protein differential expression in normal tissues for BROX Gene

This gene is overexpressed in Urine (9.3) and Heart (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BROX Gene

SOURCE GeneReport for Unigene cluster for BROX Gene Hs.552608

genes like me logo Genes that share expressions with BROX: view

Expression partners for BROX Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BROX Gene

Orthologs for BROX Gene

This gene was present in the common ancestor of animals.

Orthologs for BROX Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BROX 35
  • 93.67 (n)
  • 96.35 (a)
  • 96 (a)
(Canis familiaris)
Mammalia BROX 35
  • 92.62 (n)
  • 95.13 (a)
  • 95 (a)
(Mus musculus)
Mammalia Brox 35
  • 85.81 (n)
  • 91.73 (a)
Brox 16
Brox 36
  • 92 (a)
(Pan troglodytes)
Mammalia BROX 35
  • 99.43 (n)
  • 99.51 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Brox 35
  • 85.89 (n)
  • 92.46 (a)
(Monodelphis domestica)
Mammalia BROX 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia BROX 36
  • 89 (a)
(Gallus gallus)
Aves BROX 35
  • 79.56 (n)
  • 86.37 (a)
  • 86 (a)
(Anolis carolinensis)
Reptilia BROX 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia brox 35
  • 73.64 (n)
  • 82.24 (a)
(Danio rerio)
Actinopterygii brox 35
  • 67.32 (n)
  • 73.9 (a)
brox 36
  • 74 (a)
(Caenorhabditis elegans)
Secernentea B0507.2 35
  • 51.82 (n)
  • 40.15 (a)
B0507.2 36
  • 38 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4626 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6818 36
  • 46 (a)
Species with no ortholog for BROX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BROX Gene

Gene Tree for BROX (if available)
Gene Tree for BROX (if available)

Paralogs for BROX Gene

No data available for Paralogs for BROX Gene

Variants for BROX Gene

Sequence variations from dbSNP and Humsavar for BROX Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1986348 -- 222,732,435(+) GTTTT(C/T)ATCTC intron-variant
rs377456720 -- 222,723,595(+) CATTC(A/G)AAATC intron-variant
rs377488920 -- 222,722,481(+) GTATA(C/T)CAAAT intron-variant, reference, missense
rs377443629 -- 222,725,586(+) TTAAA(C/T)GAAAG intron-variant
rs377432522 -- 222,717,743(+) AAGTC(C/T)GTGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BROX Gene

Variant ID Type Subtype PubMed ID
nsv873205 CNV Loss 21882294
esv2668629 CNV Deletion 23128226

Relevant External Links for BROX Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BROX Gene

Disorders for BROX Gene

No disorders were found for BROX Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for BROX Gene

Publications for BROX Gene

  1. Brox, a novel farnesylated Bro1 domain-containing protein that associates with charged multivesicular body protein 4 (CHMP4). (PMID: 18190528) Ichioka F. … Maki M. (FEBS J. 2008) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Towards complete sets of farnesylated and geranylgeranylated proteins. (PMID: 17411337) Maurer-Stroh S. … Eisenhaber F. (PLoS Comput. Biol. 2007) 3 4
  4. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for BROX Gene

Sources for BROX Gene

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