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Aliases for BROX Gene

Aliases for BROX Gene

  • BRO1 Domain And CAAX Motif Containing 2 3 5
  • C1orf58 3 4
  • BRO1 Domain- And CAAX Motif-Containing Protein 4
  • BRO1 Domain-Containing Protein BROX 3
  • Chromosome 1 Open Reading Frame 58 2
  • BRO1 Domain Containing Protein 2
  • BROFTI 4

External Ids for BROX Gene

Previous HGNC Symbols for BROX Gene

  • C1orf58

Previous GeneCards Identifiers for BROX Gene

  • GC01P222886

Summaries for BROX Gene

GeneCards Summary for BROX Gene

BROX (BRO1 Domain And CAAX Motif Containing) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BROX Gene

Genomics for BROX Gene

Regulatory Elements for BROX Gene

Enhancers for BROX Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G222653 1.8 FANTOM5 Ensembl ENCODE dbSUPER 37.6 -58.0 -58018 2.8 PKNOX1 TBL1XR1 RAD21 CBX5 ZNF143 RELB ETV6 IKZF2 CREM ZNF263 BROX ENSG00000272750 AIDA TLR5 ENSG00000229399
GH01G222710 1.4 ENCODE dbSUPER 33.3 -0.1 -61 3.9 CREB3L1 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D SSRP1 BROX CICP13 ENSG00000272750 FAM177B GC01M222708
GH01G222771 1 Ensembl ENCODE 27.6 +60.2 60248 2.0 ZNF202 PKNOX1 MTA2 HLF MAX EBF1 TBX21 RAD51 POLR2A SMARCA4 BROX FAM177B LOC102724017 DISP1 LOC105372984
GH01G222736 0.7 ENCODE 32.5 +24.6 24553 1.8 FOXA2 HLF TEAD4 ZNF140 FEZF1 FOXA1 JUND HDAC2 FOS FOXP2 BROX ENSG00000272750 FAM177B GC01P222732
GH01G222669 0.6 dbSUPER 32 -41.8 -41797 2.0 ZNF335 HNRNPUL1 PKNOX1 PRDM6 ZXDB ZBTB17 BROX ENSG00000272750 GC01M222703
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BROX on UCSC Golden Path with GeneCards custom track

Promoters for BROX Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000020663 47 3601 CREB3L1 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 MEF2D SSRP1 ZNF610

Genomic Location for BROX Gene

Chromosome:
1
Start:
222,712,553 bp from pter
End:
222,735,196 bp from pter
Size:
22,644 bases
Orientation:
Plus strand

Genomic View for BROX Gene

Genes around BROX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BROX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BROX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BROX Gene

Proteins for BROX Gene

  • Protein details for BROX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VW32-BROX_HUMAN
    Recommended name:
    BRO1 domain-containing protein BROX
    Protein Accession:
    Q5VW32
    Secondary Accessions:
    • B7Z9G5
    • Q96MG1

    Protein attributes for BROX Gene

    Size:
    411 amino acids
    Molecular mass:
    46476 Da
    Quaternary structure:
    • Interacts with CHMP4B.

    Three dimensional structures from OCA and Proteopedia for BROX Gene

    Alternative splice isoforms for BROX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BROX Gene

Post-translational modifications for BROX Gene

  • Ubiquitination at Lys155 and posLast=334334
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BROX Gene

Domains & Families for BROX Gene

Protein Domains for BROX Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BROX Gene

Graphical View of Domain Structure for InterPro Entry

Q5VW32

UniProtKB/Swiss-Prot:

BROX_HUMAN :
  • Belongs to the BROX family.
Family:
  • Belongs to the BROX family.
genes like me logo Genes that share domains with BROX: view

No data available for Gene Families for BROX Gene

Function for BROX Gene

genes like me logo Genes that share phenotypes with BROX: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BROX Gene

Localization for BROX Gene

Subcellular locations from UniProtKB/Swiss-Prot for BROX Gene

Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BROX gene
Compartment Confidence
extracellular 5
mitochondrion 2
nucleus 2
cytosol 2
golgi apparatus 2
endosome 2

Gene Ontology (GO) - Cellular Components for BROX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with BROX: view

Pathways & Interactions for BROX Gene

No Data Available

Gene Ontology (GO) - Biological Process for BROX Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BROX Gene

Drugs & Compounds for BROX Gene

No Compound Related Data Available

Transcripts for BROX Gene

Unigene Clusters for BROX Gene

BRO1 domain and CAAX motif containing:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for BROX Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - -
SP2:
SP3:

Relevant External Links for BROX Gene

GeneLoc Exon Structure for
BROX
ECgene alternative splicing isoforms for
BROX

Expression for BROX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BROX Gene

Protein differential expression in normal tissues from HIPED for BROX Gene

This gene is overexpressed in Urine (9.3) and Heart (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for BROX Gene



Protein tissue co-expression partners for BROX Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BROX Gene:

BROX

SOURCE GeneReport for Unigene cluster for BROX Gene:

Hs.552608

Evidence on tissue expression from TISSUES for BROX Gene

  • Nervous system(4.4)
  • Muscle(4.3)
genes like me logo Genes that share expression patterns with BROX: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BROX Gene

Orthologs for BROX Gene

This gene was present in the common ancestor of animals.

Orthologs for BROX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BROX 34 35
  • 99.43 (n)
cow
(Bos Taurus)
Mammalia BROX 34 35
  • 93.67 (n)
dog
(Canis familiaris)
Mammalia BROX 34 35
  • 92.62 (n)
oppossum
(Monodelphis domestica)
Mammalia BROX 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BROX 35
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Brox 34
  • 85.89 (n)
mouse
(Mus musculus)
Mammalia Brox 34 16 35
  • 85.81 (n)
chicken
(Gallus gallus)
Aves BROX 34 35
  • 79.56 (n)
lizard
(Anolis carolinensis)
Reptilia BROX 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia brox 34
  • 73.64 (n)
zebrafish
(Danio rerio)
Actinopterygii brox 34 35
  • 67.32 (n)
worm
(Caenorhabditis elegans)
Secernentea B0507.2 34 35
  • 51.82 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6818 35
  • 46 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4626 34
Species where no ortholog for BROX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BROX Gene

ENSEMBL:
Gene Tree for BROX (if available)
TreeFam:
Gene Tree for BROX (if available)

Paralogs for BROX Gene

No data available for Paralogs for BROX Gene

Variants for BROX Gene

Sequence variations from dbSNP and Humsavar for BROX Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000095755 -- 222,711,862(+) AGGAG(A/G)AGGAA intron-variant, upstream-variant-2KB
rs1000323571 -- 222,715,151(+) TGTCC(A/C)ACCAA intron-variant, utr-variant-5-prime
rs1000553936 -- 222,728,168(+) TGCTA(C/T)ATGAA intron-variant
rs1000718400 -- 222,715,536(+) AACCC(C/T)GTCTC intron-variant
rs1000882652 -- 222,735,329(+) ATCCT(A/G)GCATT downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for BROX Gene

Variant ID Type Subtype PubMed ID
esv2668629 CNV deletion 23128226
esv3588948 CNV loss 21293372

Variation tolerance for BROX Gene

Residual Variation Intolerance Score: 13.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.15; 38.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BROX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BROX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BROX Gene

Disorders for BROX Gene

Relevant External Links for BROX

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BROX

No disorders were found for BROX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BROX Gene

Publications for BROX Gene

  1. Brox, a novel farnesylated Bro1 domain-containing protein that associates with charged multivesicular body protein 4 (CHMP4). (PMID: 18190528) Ichioka F. … Maki M. (FEBS J. 2008) 2 3 4 64
  2. Towards complete sets of farnesylated and geranylgeranylated proteins. (PMID: 17411337) Maurer-Stroh S. … Eisenhaber F. (PLoS Comput. Biol. 2007) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Structural Study of the HD-PTP Bro1 Domain in a Complex with the Core Region of STAM2, a Subunit of ESCRT-0. (PMID: 26866605) Lee J. … Kim S.J. (PLoS ONE 2016) 3 64
  5. The neuronal-specific SGK1.1 (SGK1_v2) kinase as a transcriptional modulator of BAG4, Brox, and PPP1CB genes expression. (PMID: 25849655) GonzA!lez-FernA!ndez R. … MartA-n-Vasallo P. (Int J Mol Sci 2015) 3 64

Products for BROX Gene

  • Addgene plasmids for BROX

Sources for BROX Gene

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