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Aliases for BROX Gene

Aliases for BROX Gene

  • BRO1 Domain And CAAX Motif Containing 2 3
  • C1orf58 3 4
  • BRO1 Domain- And CAAX Motif-Containing Protein 4
  • BRO1 Domain-Containing Protein BROX 3
  • Chromosome 1 Open Reading Frame 58 2
  • BRO1 Domain Containing Protein 2
  • BROFTI 4

External Ids for BROX Gene

Previous Symbols for BROX Gene

  • C1orf58

Summaries for BROX Gene

GeneCards Summary for BROX Gene

BROX (BRO1 Domain And CAAX Motif Containing) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BROX Gene

Genomics for BROX Gene

Genomic Location for BROX Gene

Start:
222,712,553 bp from pter
End:
222,735,196 bp from pter
Size:
22,644 bases
Orientation:
Plus strand

Genomic View for BROX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BROX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BROX Gene

No data available for Regulatory Elements for BROX Gene

Proteins for BROX Gene

  • Protein details for BROX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VW32-BROX_HUMAN
    Recommended name:
    BRO1 domain-containing protein BROX
    Protein Accession:
    Q5VW32
    Secondary Accessions:
    • B7Z9G5
    • Q96MG1

    Protein attributes for BROX Gene

    Size:
    411 amino acids
    Molecular mass:
    46476 Da
    Quaternary structure:
    • Interacts with CHMP4B.

    Three dimensional structures from OCA and Proteopedia for BROX Gene

    Alternative splice isoforms for BROX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BROX Gene

Proteomics data for BROX Gene at MOPED

Post-translational modifications for BROX Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys155 and Lys334

No data available for DME Specific Peptides for BROX Gene

Domains for BROX Gene

Protein Domains for BROX Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

BROX_HUMAN
Domain:
  • Contains 1 BRO1 domain.:
    • Q5VW32
Family:
  • Belongs to the BROX family.:
    • Q5VW32
genes like me logo Genes that share domains with BROX: view

No data available for Gene Families for BROX Gene

Function for BROX Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BROX Gene

Localization for BROX Gene

Subcellular locations from UniProtKB/Swiss-Prot for BROX Gene

Membrane; Lipid-anchor.

Gene Ontology (GO) - Cellular Components for BROX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with BROX: view

Pathways for BROX Gene

SuperPathways for BROX Gene

No Data Available

Interacting Proteins for BROX Gene

Gene Ontology (GO) - Biological Process for BROX Gene

None

No data available for Pathways by source for BROX Gene

Transcripts for BROX Gene

Unigene Clusters for BROX Gene

BRO1 domain and CAAX motif containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BROX Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - -
SP2:
SP3:

Relevant External Links for BROX Gene

GeneLoc Exon Structure for
BROX
ECgene alternative splicing isoforms for
BROX

Expression for BROX Gene

mRNA expression in normal human tissues for BROX Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BROX Gene

SOURCE GeneReport for Unigene cluster for BROX Gene Hs.552608

genes like me logo Genes that share expressions with BROX: view

Orthologs for BROX Gene

This gene was present in the common ancestor of animals.

Orthologs for BROX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BROX 36
  • 99.43 (n)
  • 99.51 (a)
BROX 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BROX 36
  • 93.67 (n)
  • 96.35 (a)
BROX 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BROX 36
  • 92.62 (n)
  • 95.13 (a)
BROX 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Brox 36
  • 85.81 (n)
  • 91.73 (a)
Brox 16
Brox 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BROX 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BROX 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Brox 36
  • 85.89 (n)
  • 92.46 (a)
chicken
(Gallus gallus)
Aves BROX 36
  • 79.56 (n)
  • 86.37 (a)
BROX 37
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BROX 37
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia brox 36
  • 73.64 (n)
  • 82.24 (a)
zebrafish
(Danio rerio)
Actinopterygii brox 36
  • 67.32 (n)
  • 73.9 (a)
brox 37
  • 74 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea B0507.2 36
  • 51.82 (n)
  • 40.15 (a)
B0507.2 37
  • 38 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4626 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6818 37
  • 46 (a)
OneToOne
Species with no ortholog for BROX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BROX Gene

ENSEMBL:
Gene Tree for BROX (if available)
TreeFam:
Gene Tree for BROX (if available)

Paralogs for BROX Gene

No data available for Paralogs for BROX Gene

Variants for BROX Gene

Sequence variations from dbSNP and Humsavar for BROX Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1986348 -- 222,732,435(+) GTTTT(C/T)ATCTC intron-variant
rs2378604 -- 222,730,968(+) TCACC(A/T)TCTGT intron-variant
rs2378605 -- 222,732,211(+) CTTTT(C/T)TTAAT intron-variant
rs3762305 -- 222,729,771(-) TAAGC(A/G)TATAT intron-variant
rs4240934 -- 222,730,956(+) TCAAA(C/T)TGTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BROX Gene

Variant ID Type Subtype PubMed ID
nsv873205 CNV Loss 21882294
esv2668629 CNV Deletion 23128226

Relevant External Links for BROX Gene

HapMap Linkage Disequilibrium report
BROX

Disorders for BROX Gene

No disorders were found for BROX Gene.

No data available for UniProtKB/Swiss-Prot for BROX Gene

Publications for BROX Gene

  1. Brox, a novel farnesylated Bro1 domain-containing protein that associates with charged multivesicular body protein 4 (CHMP4). (PMID: 18190528) Ichioka F. … Maki M. (FEBS J. 2008) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Towards complete sets of farnesylated and geranylgeranylated proteins. (PMID: 17411337) Maurer-Stroh S. … Eisenhaber F. (PLoS Comput. Biol. 2007) 3 4
  4. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for BROX Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate BROX
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for BROX
    • Block miRNA regulation of BROX using miScript Target Protectors

    Sources for BROX Gene

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