BROX Gene
protein-coding GIFtS: 39
GCID: GC01P222886
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BRO1 domain and CAAX motif containing(Previous name: chromosome 1 open reading frame 58 )
(Previous symbol: C1orf58)
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Aliases
for BROX gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| BRO1 Domain And CAAX Motif Containing1 2 | | RP11-452F19.12 | | C1orf581 2 3 | | BRO1 Domain Containing Protein2 | | BRO1 Domain- And CAAX Motif-Containing Protein2 3 | | BRO1 Domain-Containing Protein BROX2 | | FLJ324211 | | Bro1-Domain-Containing Protein2 | | Chromosome 1 Open Reading Frame 581 | | BROFTI3 |
Export aliases for BROX gene to outside databases |
Summaries
for BROX gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for BROX gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for BROX
Other transcription factors
Search SABiosciences Chromatin IP Primers for BROX
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BROX |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q41 Ensembl cytogenetic band: 1q41 HGNC cytogenetic band: 1q41BROX Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P222886: view genomic region
(about GC identifiers)
Start:
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222,885,895 bp from pter |
End:
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222,908,538 bp from pter |
Size:
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22,644 bases |
Orientation:
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plus strand |
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Proteins
for BROX gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BROX_HUMAN, Q5VW32 (See
protein sequence)Recommended Name: BRO1 domain-containing protein BROX precursor Size: 411 amino acids; 46476 Da
Subunit: Interacts with CHMP4B
Subcellular location: Membrane; Lipid-anchor (Potential)
6/7 PDB 3D structures from  and Proteopedia  for BROX (see all 7):3R9M (3D)
3ULY (3D)
3UM0 (3D)
3UM1 (3D)
3UM2 (3D)
3UM3 (3D)
Secondary accessions: Q96MG1Explore the universe of human proteins at neXtProt for BROX: NX_Q5VW32
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5VW32
BROX Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_653296.2
ENSEMBL proteins: ENSP00000343742 ENSP00000398862 ENSP00000441080 ENSP00000440041
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0016020 | membrane |
IEA | -- |
BROX for ontologies About GeneDecksing
BROX Antibody Products:
Assay Products for BROX: |
Protein
Domains /
Families
for BROX gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BROX for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5VW32ProtoNet protein and cluster: Q5VW32 UniProtKB/Swiss-Prot: BROX_HUMAN, Q5VW32Similarity: Belongs to the BROX familySimilarity: Contains 1 BRO1 domain |
Function
for BROX gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BROX (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BROX
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: BROX (NM_144695) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BROX | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BROX |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BROX |
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Pathways & Interactions
for BROX gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BROX
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for BROX (ENSP000003437424) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for BROX gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BROX
Search CenterWatch for drugs/clinical trials and news about BROX
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Transcripts
for BROX gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BROX gene: NM_144695.2 Unigene Cluster for BROX: BRO1 domain and CAAX motif containing Hs.552608 [show with all ESTs]Unigene Representative Sequence: AK0949168 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000340934(uc001hnq.1 uc010put.1) ENST00000496267(uc001hnp.1)
ENST00000426638 ENST00000473962 ENST00000469236 ENST00000489191 ENST00000539697(uc010puv.1)
ENST00000537020(uc010puu.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BROX (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BROX
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: BROX (NM_144695) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BROX | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BROX |
Additional cDNA sequence: AB276123.1 AK056983.1 AK094916.1 AK293974.1 AK304445.1 AK315930.1 BC053552.1 BC105293.1 BC113635.1 BC113637.1 BC143811.1 9 DOTS entries: DT.97797499 DT.97809992 DT.91691294 DT.100001492 DT.97826885 DT.100030193 DT.99936112 DT.99992366 DT.91811207 24/114 AceView cDNA sequences (see all 114): AI982671 AI024071 AA444170 AI624539 AI978719 BX107721 AI620186 CA436494 AI470698 BI757295 AI399715 CN478796 AW068491 AI753272 AA953958 BM722436 BG621722 CB305418 CK570358 BG029793 AA884496 BC053552 BQ921631 AI911339
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for BROX About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 |
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| SP1: | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for BROX
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Expression
for BROX gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BROX expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGAGACTTT
About this image
See BROX Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BROX
SOURCE GeneReport for Unigene cluster: Hs.552608
SABiosciences Custom PCR Arrays for BROX
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BROX
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat BROX | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BROX | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BROX | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BROX |
Orthologs
for BROX gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for BROX gene from 6/19 species (see all 19) About this table
ENSEMBL Gene Tree for BROX (if available)
TreeFam Gene Tree for BROX (if available) |
Paralogs
for BROX gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for BROX gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BROX |
|
Disorders
/ Diseases
for BROX gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for BROX gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BROX gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with BROX) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Brox, a novel farnesylated Bro1 domain-containing protein that associates with charged multivesicular body protein 4 (CHMP4). (PubMed id 18190528)1, 2, 3 Ichioka F.... Maki M. (2008)
- Towards complete sets of farnesylated and geranylgeranylated proteins. (PubMed id 17411337)1, 2 Maurer-Stroh S....Eisenhaber F. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Structure of the Bro1 domain protein BROX and functio nal analyses of the ALIX Bro1 domain in HIV-1 budding. (PubMed id 22162750)1 Zhai Q....Hill C.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- The Phe105 loop of Alix Bro1 domain plays a key role in HIV-1 release. (PubMed id 21889351)2 Sette P....Bouamr F. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- Divergent Bro1 domains share the capacity to bind hum an immunodeficiency virus type 1 nucleocapsid and to enhance virus-like particl e production. (PubMed id 19403673)1 Popov S....GAPttlinger H.G. (2009)
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External Searches for BROX gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing BROX gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BROX gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BROX gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for BROX | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for BROX gene:
Search GeneIP for patents involving BROX
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BROX gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for BROX | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BROX | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BROX | | | OriGene Protein Over-expression Lysate for BROX | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BROX | | OriGene 3'-UTR Clone for BROX | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BROX | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BROX | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for BROX | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for BROX | | OriGene Custom Protein Services for BROX | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BROX | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BROX | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BROX | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BROX | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BROX | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BROX |
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| | | | Search Tocris compounds for BROX |
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 | | | BROX Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BROX |
|  |  |  | | | | ThermoFisher Antibody for BROX |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BROX |
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