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Aliases for BROX Gene

Aliases for BROX Gene

  • BRO1 Domain And CAAX Motif Containing 2 3
  • C1orf58 3 4
  • BRO1 Domain- And CAAX Motif-Containing Protein 4
  • Chromosome 1 Open Reading Frame 58 2
  • BRO1 Domain Containing Protein 2
  • BROFTI 4

External Ids for BROX Gene

Previous HGNC Symbols for BROX Gene

  • C1orf58

Previous GeneCards Identifiers for BROX Gene

  • GC01P222886

Summaries for BROX Gene

GeneCards Summary for BROX Gene

BROX (BRO1 Domain And CAAX Motif Containing) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BROX Gene

Genomics for BROX Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BROX Gene

222,712,553 bp from pter
222,735,196 bp from pter
22,644 bases
Plus strand

Genomic View for BROX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BROX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BROX Gene

No data available for Regulatory Elements for BROX Gene

Proteins for BROX Gene

  • Protein details for BROX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BRO1 domain-containing protein BROX
    Protein Accession:
    Secondary Accessions:
    • B7Z9G5
    • Q96MG1

    Protein attributes for BROX Gene

    411 amino acids
    Molecular mass:
    46476 Da
    Quaternary structure:
    • Interacts with CHMP4B.

    Three dimensional structures from OCA and Proteopedia for BROX Gene

    Alternative splice isoforms for BROX Gene


neXtProt entry for BROX Gene

Proteomics data for BROX Gene at MOPED

Post-translational modifications for BROX Gene

  • Ubiquitination at Lys 155 and Lys 334
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BROX Gene

Domains & Families for BROX Gene

Protein Domains for BROX Gene


Suggested Antigen Peptide Sequences for BROX Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BRO1 domain.
  • Belongs to the BROX family.
  • Contains 1 BRO1 domain.
  • Belongs to the BROX family.
genes like me logo Genes that share domains with BROX: view

No data available for Gene Families for BROX Gene

Function for BROX Gene

genes like me logo Genes that share phenotypes with BROX: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BROX

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for BROX Gene

Localization for BROX Gene

Subcellular locations from UniProtKB/Swiss-Prot for BROX Gene

Membrane; Lipid-anchor.

Subcellular locations from

Jensen Localization Image for BROX Gene COMPARTMENTS Subcellular localization image for BROX gene
Compartment Confidence
extracellular 5
cytosol 2
endosome 2
golgi apparatus 2
nucleus 2

Gene Ontology (GO) - Cellular Components for BROX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with BROX: view

Pathways & Interactions for BROX Gene

SuperPathways for BROX Gene

No Data Available

Interacting Proteins for BROX Gene

Gene Ontology (GO) - Biological Process for BROX Gene


No data available for Pathways by source and SIGNOR curated interactions for BROX Gene

Drugs & Compounds for BROX Gene

No Compound Related Data Available

Transcripts for BROX Gene

Unigene Clusters for BROX Gene

BRO1 domain and CAAX motif containing:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BROX

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BROX Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - -

Relevant External Links for BROX Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BROX Gene

mRNA expression in normal human tissues for BROX Gene

Protein differential expression in normal tissues from HIPED for BROX Gene

This gene is overexpressed in Urine (9.3) and Heart (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BROX Gene

SOURCE GeneReport for Unigene cluster for BROX Gene Hs.552608

genes like me logo Genes that share expression patterns with BROX: view

Protein tissue co-expression partners for BROX Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BROX Gene

Orthologs for BROX Gene

This gene was present in the common ancestor of animals.

Orthologs for BROX Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BROX 35
  • 93.67 (n)
  • 96.35 (a)
  • 96 (a)
(Canis familiaris)
Mammalia BROX 35
  • 92.62 (n)
  • 95.13 (a)
  • 95 (a)
(Mus musculus)
Mammalia Brox 35
  • 85.81 (n)
  • 91.73 (a)
Brox 16
Brox 36
  • 92 (a)
(Pan troglodytes)
Mammalia BROX 35
  • 99.43 (n)
  • 99.51 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Brox 35
  • 85.89 (n)
  • 92.46 (a)
(Monodelphis domestica)
Mammalia BROX 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia BROX 36
  • 89 (a)
(Gallus gallus)
Aves BROX 35
  • 79.56 (n)
  • 86.37 (a)
  • 86 (a)
(Anolis carolinensis)
Reptilia BROX 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia brox 35
  • 73.64 (n)
  • 82.24 (a)
(Danio rerio)
Actinopterygii brox 35
  • 67.32 (n)
  • 73.9 (a)
brox 36
  • 74 (a)
(Caenorhabditis elegans)
Secernentea B0507.2 35
  • 51.82 (n)
  • 40.15 (a)
B0507.2 36
  • 38 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4626 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6818 36
  • 46 (a)
Species with no ortholog for BROX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BROX Gene

Gene Tree for BROX (if available)
Gene Tree for BROX (if available)

Paralogs for BROX Gene

No data available for Paralogs for BROX Gene

Variants for BROX Gene

Sequence variations from dbSNP and Humsavar for BROX Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1986348 -- 222,732,435(+) GTTTT(C/T)ATCTC intron-variant
rs2378604 -- 222,730,968(+) TCACC(A/T)TCTGT intron-variant
rs2378605 -- 222,732,211(+) CTTTT(C/T)TTAAT intron-variant
rs3762305 -- 222,729,771(-) TAAGC(A/G)TATAT intron-variant, downstream-variant-500B
rs4240934 -- 222,730,956(+) TCAAA(C/T)TGTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BROX Gene

Variant ID Type Subtype PubMed ID
nsv873205 CNV Loss 21882294
esv2668629 CNV Deletion 23128226

Variation tolerance for BROX Gene

Residual Variation Intolerance Score: 13.51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.15; 38.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BROX Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BROX Gene

Disorders for BROX Gene

Relevant External Links for BROX

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with BROX: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BROX Gene

Publications for BROX Gene

  1. Brox, a novel farnesylated Bro1 domain-containing protein that associates with charged multivesicular body protein 4 (CHMP4). (PMID: 18190528) Ichioka F. … Maki M. (FEBS J. 2008) 2 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 67
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 67
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 67

Products for BROX Gene

Sources for BROX Gene

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