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Aliases for BRMS1L Gene

Aliases for BRMS1L Gene

  • Breast Cancer Metastasis-Suppressor 1-Like 2 3
  • Breast Cancer Metastasis-Suppressor 1 2 3
  • BRMS1-Homolog Protein P40 3 4
  • BRMS1-Like Protein P40 3 4
  • Breast Cancer Metastasis-Suppressor 1-Like Protein 3
  • BRMS1 3

External Ids for BRMS1L Gene

Previous HGNC Symbols for BRMS1L Gene

  • BRMS1

Previous GeneCards Identifiers for BRMS1L Gene

  • GC14P034286
  • GC14P034287
  • GC14P035365
  • GC14P036295
  • GC14P016409

Summaries for BRMS1L Gene

Entrez Gene Summary for BRMS1L Gene

  • The protein encoded by this gene shows sequence similarity to the human breast carcinoma metastasis suppressor (BRMS1) protein and the mammalian Sds3 (suppressor of defective silencing 3) proteins. This protein is a component of the mSin3a family of histone deacetylase complexes (HDAC). [provided by RefSeq, Jul 2008]

GeneCards Summary for BRMS1L Gene

BRMS1L (Breast Cancer Metastasis-Suppressor 1-Like) is a Protein Coding gene. Diseases associated with BRMS1L include breast cancer. An important paralog of this gene is SUDS3.

UniProtKB/Swiss-Prot for BRMS1L Gene

  • Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRMS1L Gene

Genomics for BRMS1L Gene

Regulatory Elements for BRMS1L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BRMS1L Gene

Start:
35,826,318 bp from pter
End:
35,932,325 bp from pter
Size:
106,008 bases
Orientation:
Plus strand

Genomic View for BRMS1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BRMS1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRMS1L Gene

Proteins for BRMS1L Gene

  • Protein details for BRMS1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5PSV4-BRM1L_HUMAN
    Recommended name:
    Breast cancer metastasis-suppressor 1-like protein
    Protein Accession:
    Q5PSV4
    Secondary Accessions:
    • A6NFW5
    • A6NH45
    • B2RD65
    • Q9BRI4

    Protein attributes for BRMS1L Gene

    Size:
    323 amino acids
    Molecular mass:
    37629 Da
    Quaternary structure:
    • Component of the Sin3/HDAC1 corepressor complex at least composed of BRMS1, BRMS1L and ING2/ING1L. Interacts with HDAC and SIN3A.

    Alternative splice isoforms for BRMS1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BRMS1L Gene

Proteomics data for BRMS1L Gene at MOPED

Post-translational modifications for BRMS1L Gene

  • Ubiquitination at Lys76
  • Modification sites at PhosphoSitePlus

Other Protein References for BRMS1L Gene

No data available for DME Specific Peptides for BRMS1L Gene

Domains for BRMS1L Gene

Protein Domains for BRMS1L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BRMS1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5PSV4

UniProtKB/Swiss-Prot:

BRM1L_HUMAN :
  • Q5PSV4
Family:
  • Belongs to the BRMS1 family.
genes like me logo Genes that share domains with BRMS1L: view

No data available for Gene Families for BRMS1L Gene

Function for BRMS1L Gene

Molecular function for BRMS1L Gene

UniProtKB/Swiss-Prot Function: Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth.

Gene Ontology (GO) - Molecular Function for BRMS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004407 contributes_to histone deacetylase activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0042826 histone deacetylase binding IBA --
genes like me logo Genes that share ontologies with BRMS1L: view

Phenotypes for BRMS1L Gene

GenomeRNAi human phenotypes for BRMS1L:
genes like me logo Genes that share phenotypes with BRMS1L: view

Animal Model Products

CRISPR Products

miRNA for BRMS1L Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BRMS1L

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for BRMS1L Gene

Localization for BRMS1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRMS1L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BRMS1L Gene COMPARTMENTS Subcellular localization image for BRMS1L gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for BRMS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0070822 Sin3-type complex IBA --
genes like me logo Genes that share ontologies with BRMS1L: view

Pathways for BRMS1L Gene

SuperPathways for BRMS1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for BRMS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0016575 histone deacetylation IBA --
GO:0040008 regulation of growth IEA --
genes like me logo Genes that share ontologies with BRMS1L: view

No data available for Pathways by source for BRMS1L Gene

Transcripts for BRMS1L Gene

Unigene Clusters for BRMS1L Gene

Breast cancer metastasis-suppressor 1-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BRMS1L

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BRMS1L Gene

No ASD Table

Relevant External Links for BRMS1L Gene

GeneLoc Exon Structure for
BRMS1L
ECgene alternative splicing isoforms for
BRMS1L

Expression for BRMS1L Gene

mRNA expression in normal human tissues for BRMS1L Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BRMS1L Gene

SOURCE GeneReport for Unigene cluster for BRMS1L Gene Hs.525299

genes like me logo Genes that share expressions with BRMS1L: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BRMS1L Gene

Orthologs for BRMS1L Gene

This gene was present in the common ancestor of animals.

Orthologs for BRMS1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BRMS1L 35
  • 99.69 (n)
  • 100 (a)
BRMS1L 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 93 (a)
OneToMany
BRMS1L 35
  • 96.08 (n)
  • 100 (a)
BRMS1L 36
  • 100 (a)
OneToMany
dog
(Canis familiaris)
Mammalia BRMS1L 36
  • 100 (a)
OneToOne
LOC480292 35
  • 96.9 (n)
  • 99.69 (a)
mouse
(Mus musculus)
Mammalia Brms1l 35
  • 90.71 (n)
  • 99.69 (a)
Brms1l 16
Brms1l 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BRMS1L 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BRMS1L 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910898 35
  • 91.74 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves BRMS1L 35
  • 85.57 (n)
  • 95.33 (a)
BRMS1L 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BRMS1L 36
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21343 35
tropical clawed frog
(Silurana tropicalis)
Amphibia brms1l 35
  • 79.27 (n)
  • 91.25 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.443 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
brms1la 35
  • 76.84 (n)
  • 87.23 (a)
brms1la 36
  • 85 (a)
OneToMany
brms1lb 36
  • 78 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002712 35
  • 53.24 (n)
  • 51.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4400 35
  • 47.66 (n)
  • 41.63 (a)
CG4400 36
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8326 36
  • 33 (a)
OneToMany
Species with no ortholog for BRMS1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRMS1L Gene

ENSEMBL:
Gene Tree for BRMS1L (if available)
TreeFam:
Gene Tree for BRMS1L (if available)

Paralogs for BRMS1L Gene

Paralogs for BRMS1L Gene

Selected SIMAP similar genes for BRMS1L Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with BRMS1L: view

Variants for BRMS1L Gene

Sequence variations from dbSNP and Humsavar for BRMS1L Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs725998 -- 35,835,758(-) aagca(A/G)tcccc intron-variant
rs1059561 -- 35,871,180(+) CTGTA(A/T)TTCTA utr-variant-3-prime
rs1059562 -- 35,871,411(+) TTTTT(C/T)TTTGG utr-variant-3-prime
rs1169019 -- 35,856,760(-) gcaga(C/T)gcctg intron-variant
rs1169020 -- 35,856,658(-) ctcca(C/G)ccggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BRMS1L Gene

Variant ID Type Subtype PubMed ID
dgv1874n71 CNV Loss 21882294
nsv901627 CNV Loss 21882294
nsv901631 CNV Loss 21882294
nsv84518 CNV Loss 16902084

Relevant External Links for BRMS1L Gene

HapMap Linkage Disequilibrium report
BRMS1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRMS1L Gene

Disorders for BRMS1L Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for BRMS1L Gene including...

Search for BRMS1L Gene in MalaCards »

(1) University of Copenhagen DISEASES for BRMS1L Gene

Relevant External Links for BRMS1L

Genetic Association Database (GAD)
BRMS1L
genes like me logo Genes that share disorders with BRMS1L: view

No data available for UniProtKB/Swiss-Prot for BRMS1L Gene

Publications for BRMS1L Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex. (PMID: 15451426) Nikolaev A.Y. … Gu W. (Biochem. Biophys. Res. Commun. 2004) 3 4
  3. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. (PMID: 16387653) Doyon Y. … Cote J. (Mol. Cell 2006) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. System-wide changes to SUMO modifications in response to heat shock. (PMID: 19471022) Golebiowski F. … Hay R.T. (Sci Signal 2009) 3

Products for BRMS1L Gene

Sources for BRMS1L Gene

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