Free for academic non-profit institutions. Other users need a Commercial license

Aliases for BRMS1L Gene

Aliases for BRMS1L Gene

  • Breast Cancer Metastasis-Suppressor 1-Like 2 3 5
  • Breast Cancer Metastasis-Suppressor 1 2 3
  • BRMS1-Homolog Protein P40 3 4
  • BRMS1-Like Protein P40 3 4
  • BRMS1 3

External Ids for BRMS1L Gene

Previous HGNC Symbols for BRMS1L Gene

  • BRMS1

Previous GeneCards Identifiers for BRMS1L Gene

  • GC14P034286
  • GC14P034287
  • GC14P035365
  • GC14P036295
  • GC14P016409

Summaries for BRMS1L Gene

Entrez Gene Summary for BRMS1L Gene

  • The protein encoded by this gene shows sequence similarity to the human breast carcinoma metastasis suppressor (BRMS1) protein and the mammalian Sds3 (suppressor of defective silencing 3) proteins. This protein is a component of the mSin3a family of histone deacetylase complexes (HDAC). [provided by RefSeq, Jul 2008]

GeneCards Summary for BRMS1L Gene

BRMS1L (Breast Cancer Metastasis-Suppressor 1-Like) is a Protein Coding gene. Diseases associated with BRMS1L include Breast Cancer. GO annotations related to this gene include histone deacetylase binding and histone deacetylase activity. An important paralog of this gene is SUDS3.

UniProtKB/Swiss-Prot for BRMS1L Gene

  • Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRMS1L Gene

Genomics for BRMS1L Gene

Regulatory Elements for BRMS1L Gene

Enhancers for BRMS1L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BRMS1L on UCSC Golden Path with GeneCards custom track

Promoters for BRMS1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BRMS1L on UCSC Golden Path with GeneCards custom track

Genomic Location for BRMS1L Gene

Chromosome:
14
Start:
35,826,318 bp from pter
End:
35,932,325 bp from pter
Size:
106,008 bases
Orientation:
Plus strand

Genomic View for BRMS1L Gene

Genes around BRMS1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRMS1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRMS1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRMS1L Gene

Proteins for BRMS1L Gene

  • Protein details for BRMS1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5PSV4-BRM1L_HUMAN
    Recommended name:
    Breast cancer metastasis-suppressor 1-like protein
    Protein Accession:
    Q5PSV4
    Secondary Accessions:
    • A6NFW5
    • A6NH45
    • B2RD65
    • Q9BRI4

    Protein attributes for BRMS1L Gene

    Size:
    323 amino acids
    Molecular mass:
    37629 Da
    Quaternary structure:
    • Component of the Sin3/HDAC1 corepressor complex at least composed of BRMS1, BRMS1L and ING2/ING1L. Interacts with HDAC and SIN3A.

    Alternative splice isoforms for BRMS1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BRMS1L Gene

Proteomics data for BRMS1L Gene at MOPED

Post-translational modifications for BRMS1L Gene

  • Ubiquitination at Lys 76
  • Modification sites at PhosphoSitePlus

Other Protein References for BRMS1L Gene

No data available for DME Specific Peptides for BRMS1L Gene

Domains & Families for BRMS1L Gene

Protein Domains for BRMS1L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BRMS1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5PSV4

UniProtKB/Swiss-Prot:

BRM1L_HUMAN :
  • Belongs to the BRMS1 family.
Family:
  • Belongs to the BRMS1 family.
genes like me logo Genes that share domains with BRMS1L: view

No data available for Gene Families for BRMS1L Gene

Function for BRMS1L Gene

Molecular function for BRMS1L Gene

UniProtKB/Swiss-Prot Function:
Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth.

Phenotypes for BRMS1L Gene

genes like me logo Genes that share phenotypes with BRMS1L: view

Animal Model Products

miRNA for BRMS1L Gene

miRTarBase miRNAs that target BRMS1L

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BRMS1L Gene

Localization for BRMS1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRMS1L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BRMS1L Gene COMPARTMENTS Subcellular localization image for BRMS1L gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for BRMS1L Gene

Pathways & Interactions for BRMS1L Gene

SuperPathways for BRMS1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for BRMS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with BRMS1L: view

No data available for Pathways by source and SIGNOR curated interactions for BRMS1L Gene

Drugs & Compounds for BRMS1L Gene

No Compound Related Data Available

Transcripts for BRMS1L Gene

Unigene Clusters for BRMS1L Gene

Breast cancer metastasis-suppressor 1-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BRMS1L Gene

No ASD Table

Relevant External Links for BRMS1L Gene

GeneLoc Exon Structure for
BRMS1L
ECgene alternative splicing isoforms for
BRMS1L

Expression for BRMS1L Gene

mRNA expression in normal human tissues for BRMS1L Gene

Protein differential expression in normal tissues from HIPED for BRMS1L Gene

This gene is overexpressed in Placenta (15.2), Retina (12.8), Fetal testis (9.6), Pancreas (8.5), and Prostate (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BRMS1L Gene



SOURCE GeneReport for Unigene cluster for BRMS1L Gene Hs.525299

genes like me logo Genes that share expression patterns with BRMS1L: view

Protein tissue co-expression partners for BRMS1L Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BRMS1L Gene

Orthologs for BRMS1L Gene

This gene was present in the common ancestor of animals.

Orthologs for BRMS1L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BRMS1L 35
  • 96.08 (n)
  • 100 (a)
-- 36
  • 93 (a)
OneToMany
BRMS1L 36
  • 100 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC480292 35
  • 96.9 (n)
  • 99.69 (a)
BRMS1L 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Brms1l 35
  • 90.71 (n)
  • 99.69 (a)
Brms1l 16
Brms1l 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BRMS1L 35
  • 99.69 (n)
  • 100 (a)
BRMS1L 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910898 35
  • 91.74 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia BRMS1L 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BRMS1L 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves BRMS1L 35
  • 85.57 (n)
  • 95.33 (a)
BRMS1L 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BRMS1L 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia brms1l 35
  • 79.27 (n)
  • 91.25 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.21343 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
brms1la 35
  • 76.84 (n)
  • 87.23 (a)
brms1la 36
  • 85 (a)
OneToMany
brms1lb 36
  • 78 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.443 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002712 35
  • 53.24 (n)
  • 51.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4400 35
  • 47.66 (n)
  • 41.63 (a)
CG4400 36
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8326 36
  • 33 (a)
OneToMany
Species with no ortholog for BRMS1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRMS1L Gene

ENSEMBL:
Gene Tree for BRMS1L (if available)
TreeFam:
Gene Tree for BRMS1L (if available)

Paralogs for BRMS1L Gene

Paralogs for BRMS1L Gene

(3) SIMAP similar genes for BRMS1L Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with BRMS1L: view

Variants for BRMS1L Gene

Sequence variations from dbSNP and Humsavar for BRMS1L Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs7140602 -- 35,845,483(+) ctcat(C/G)atcta intron-variant
rs7141280 -- 35,832,891(+) ATGAT(A/G)TTGGG intron-variant
rs7493329 -- 35,842,999(+) atgaa(A/G)ttctc intron-variant
rs7142506 -- 35,832,755(+) TTGTA(C/T)TGGGA intron-variant
rs8003661 -- 35,870,038(+) TATAC(A/G)TAGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BRMS1L Gene

Variant ID Type Subtype PubMed ID
dgv1874n71 CNV Loss 21882294
nsv901627 CNV Loss 21882294
nsv901631 CNV Loss 21882294
nsv84518 CNV Loss 16902084

Variation tolerance for BRMS1L Gene

Residual Variation Intolerance Score: 47.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.60% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for BRMS1L Gene

Disorders for BRMS1L Gene

MalaCards: The human disease database

(1) MalaCards diseases for BRMS1L Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for BRMS1L

Genetic Association Database (GAD)
BRMS1L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BRMS1L
genes like me logo Genes that share disorders with BRMS1L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BRMS1L Gene

Publications for BRMS1L Gene

  1. Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex. (PMID: 15451426) Nikolaev A.Y. … Gu W. (Biochem. Biophys. Res. Commun. 2004) 3 4 67
  2. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for BRMS1L Gene

Sources for BRMS1L Gene

Content