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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BRMS1L Gene

protein-coding   GIFtS: 48
GCID: GC14P036295

Breast Cancer Metastasis-Suppressor 1-Like

(Previous name: breast cancer metastasis-suppressor 1)
(Previous symbol: BRMS1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Breast Cancer Metastasis-Suppressor 1-Like1 2
BRMS11 2
BRMS1-Homolog Protein P402 3
BRMS1-Like Protein P402 3
Breast Cancer Metastasis-Suppressor 11
Breast Cancer Metastasis-Suppressor 1-Like Protein2

External Ids:    HGNC: 205121   Entrez Gene: 843122   Ensembl: ENSG000001009167   UniProtKB: Q5PSV43   

Export aliases for BRMS1L gene to outside databases

Previous GC identifers: GC14P034286 GC14P034287 GC14P035365 GC14P016409


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BRMS1L Gene:
The protein encoded by this gene shows sequence similarity to the human breast carcinoma metastasis suppressor
(BRMS1) protein and the mammalian Sds3 (suppressor of defective silencing 3) proteins. This protein is a
component of the mSin3a family of histone deacetylase complexes (HDAC). (provided by RefSeq, Jul 2008)

GeneCards Summary for BRMS1L Gene: 
BRMS1L (breast cancer metastasis-suppressor 1-like) is a protein-coding gene. Diseases associated with BRMS1L include breast cancer, and prader-willi syndrome. An important paralog of this gene is SUDS3.

UniProtKB/Swiss-Prot: BRM1L_HUMAN, Q5PSV4
Function: Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When
overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BRMS1L gene promoter:
         TBP   AML1a   Nkx2-2   p300   E4BP4   C/EBPalpha   AREB6   Pax-3   c-Myb   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBRMS1L promoter sequence
   Search SABiosciences Chromatin IP Primers for BRMS1L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BRMS1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q13.2   Ensembl cytogenetic band:  14q13.2   HGNC cytogenetic band: 14q13.1

BRMS1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRMS1L gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P036295:  view genomic region     (about GC identifiers)

Start:
36,295,524 bp from pter      End:
36,401,531 bp from pter
Size:
106,008 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BRM1L_HUMAN, Q5PSV4 (See protein sequence)
Recommended Name: Breast cancer metastasis-suppressor 1-like protein  
Size: 323 amino acids; 37629 Da
Subunit: Component of the Sin3/HDAC1 corepressor complex at least composed of BRMS1, BRMS1L and ING2/ING1L.
Interacts with HDAC and SIN3A
Subcellular location: Nucleus (Probable)
Secondary accessions: A6NFW5 A6NH45 Q9BRI4

Explore the universe of human proteins at neXtProt for BRMS1L: NX_Q5PSV4

Explore proteomics data for BRMS1L at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5PSV4

  • BRMS1L Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BRMS1L Protein Expression
    REFSEQ proteins: NP_115728.2  
    ENSEMBL proteins: 
     ENSP00000216807   ENSP00000448615   ENSP00000447022   ENSP00000446826   ENSP00000443781  

    Human Recombinant Protein Products for BRMS1L: 
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    Cloud-Clone Corp. Proteins for BRMS1L 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    BRMS1L for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR013907 Sds3

    Graphical View of Domain Structure for InterPro Entry Q5PSV4

    ProtoNet protein and cluster: Q5PSV4

    UniProtKB/Swiss-Prot: BRM1L_HUMAN, Q5PSV4
    Similarity: Belongs to the BRMS1 family


    BRMS1L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BRM1L_HUMAN, Q5PSV4
    Function: Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When
    overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth

    Phenotypes:
         1 GenomeRNAi human phenotype for BRMS1L:

     Increased ID2::GFP protein exp 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for BRMS1L 
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    SwitchGear 3'UTR luciferase reporter plasmidBRMS1L 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BRMS1L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/13 Interacting proteins for BRMS1L (Q5PSV43 ENSP000002168074) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBBP4Q090283, ENSP000003625924I2D: score=1 STRING: ENSP00000362592
    RBBP7Q165763, ENSP000003694274I2D: score=1 STRING: ENSP00000369427
    SAP30O754463, ENSP000002965044I2D: score=1 STRING: ENSP00000296504
    SIN3AQ96ST33, ENSP000003536224I2D: score=1 STRING: ENSP00000353622
    HDAC1Q135473, ENSP000003626494I2D: score=1 STRING: ENSP00000362649
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0040008regulation of growth IEA--

    BRMS1L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BRMS1L (BRM1L)

    Search CenterWatch for drugs/clinical trials and news about BRMS1L / BRM1L

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BRMS1L gene: 
    NM_032352.3  

    Unigene Cluster for BRMS1L:

    Breast cancer metastasis-suppressor 1-like
    Hs.525299  [show with all ESTs]
    Unigene Representative Sequence: NM_032352
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216807(uc001wtl.3) ENST00000552677 ENST00000547420 ENST00000548758
    ENST00000551774 ENST00000552849 ENST00000543183(uc010tpx.1)
    miRNA
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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate BRMS1L (see all 28):
    hsa-miR-875-3p hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-302e hsa-miR-519a hsa-miR-223 hsa-miR-520a-3p
    SwitchGear 3'UTR luciferase reporter plasmidBRMS1L 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BRMS1L
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    Additional mRNA sequence: 

    AK096496.1 AK297106.1 AK309431.1 AK310359.1 AK315424.1 AY827074.1 BC006250.2 

    4 DOTS entries:

    DT.114699  DT.97835737  DT.91756015  DT.101968257 

    24/84 AceView cDNA sequences (see all 84):

    CR595618 NM_032352 AI889479 CB151697 BU507838 BQ071431 BC006250 BX419113 
    BM673774 AA974270 AA745745 AW203996 Z41283 AI126358 BI914436 AA308885 
    AA448679 BX452070 BM986833 CD677611 Z45595 AW304325 Z44923 BM712928 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BRMS1L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGGTCTTT
    BRMS1L Expression
    About this image


    See BRMS1L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BRMS1L

    SOURCE GeneReport for Unigene cluster: Hs.525299
        SABiosciences Custom PCR Arrays for BRMS1L
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for BRMS1L gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Brms1l1 , 5 breast cancer metastasis-suppressor 1-like1, 5 90.71(n)1
    99.69(a)1
      12 (24.18 cM)5
    525921  NM_001037756.21  NP_001032845.11 
     558363665 
    chicken
    (Gallus gallus)
    Aves BRMS1L1 breast cancer metastasis-suppressor 1-like 85.57(n)
    95.33(a)
      423328  NM_001007935.1  NP_001007936.1 
    lizard
    (Anolis carolinensis)
    Reptilia BRMS1L6
    Uncharacterized protein
    77(a)
    1 ↔ 1
    1(24178761-24205903)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.213432 Xenopus laevis transcribed sequence with weak similarity more 77.14(n)    CA787714.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC049431.12   -- 73.1(n)   368897  BC049431.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG44001 CG4400 47.55(n)
    41.71(a)
      32243  NM_132612.1  NP_572840.1 


    ENSEMBL Gene Tree for BRMS1L (if available)
    TreeFam Gene Tree for BRMS1L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BRMS1L gene
    SUDS32  BRMS12  
    3 SIMAP similar genes for BRMS1L using alignment to 4 protein entries:     BRM1L_HUMAN (see all proteins):
    DKFZp564A063    BRMS1    SUDS3

    BRMS1L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/914 SNPs in BRMS1L are shown (see all 914)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1899740681,2
    C--36293828(+) TGGCCA/GGGCGG 1 -- us2k10--------
    rs1823394351,2
    C--36294100(+) GAGGGG/TCTCCT 1 -- us2k10--------
    rs1485832421,2
    C--36294570(+) GATCAC/TTCGCG 1 -- us2k10--------
    rs1429990941,2
    C--36294574(+) ATTCGC/TGGTTA 1 -- us2k10--------
    rs1852019221,2
    --36294758(+) CGGCTA/CGGCAT 1 -- us2k10--------
    rs1132446471,2
    C,F--36294957(+) AAAAAG/ATAAAT 1 -- us2k12Minor allele frequency- A:0.33CSA 3
    rs1910451001,2
    --36294991(+) GCCAAA/GATAAA 1 -- us2k10--------
    rs1838886471,2
    --36295060(+) CACAGA/TAAGTG 1 -- us2k10--------
    rs1398382261,2
    C--36295428(+) ACCTAA/CGAACT 1 -- us2k10--------
    rs1153461421,2
    C,F--36295674(+) GCGGCG/AGTGGC 1 -- ut511Minor allele frequency- A:0.07WA 118

    HapMap Linkage Disequilibrium report for BRMS1L (36295524 - 36401531 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for BRMS1L:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv901631CNV Loss21882294
    dgv1874n71CNV Loss21882294
    nsv84518CNV Loss16902084
    nsv901627CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for BRMS1L:    About MalaCards
    breast cancer    prader-willi syndrome    lung cancer

    1 disease from the University of Copenhagen DISEASES database for BRMS1L:
    Breast cancer

    BRMS1L for disorders           About GeneDecksing

    Genetic Association Database (GAD): BRMS1L

    Export disorders for BRMS1L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BRMS1L gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with BRMS1L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex. (PubMed id 15451426)1, 2 Nikolaev A.Y.... Gu W. (2004)
    2. The functional interactome landscape of the human hist one deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (2013)
    3. Discovery of common variants associated with low TSH l evels and thyroid cancer risk. (PubMed id 22267200)4 Gudmundsson J....Stefansson K. (2012)
    4. Association between SNP-genotype and chronic lymphocy tic leukemia outcome in a randomized chemotherapy trial. (PubMed id 21659360)4 Wade R....Houlston R.S. (2011)
    5. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    6. System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (2009)
    7. Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations. (PubMed id 19198613)4 Gudmundsson J....Stefansson K. (2009)
    8. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    10. Genome-wide association of sleep and circadian phenotypes. (PubMed id 17903308)4 Gottlieb D.J....Wilk J.B. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84312 HGNC: 20512 AceView: BRMS1L Ensembl:ENSG00000100916 euGenes: HUgn84312
    ECgene: BRMS1L H-InvDB: BRMS1L

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BRMS1L Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BRMS1L Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BRMS1L gene:
    Search GeneIP for patents involving BRMS1L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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