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Aliases for BRMS1L Gene

Aliases for BRMS1L Gene

  • Breast Cancer Metastasis-Suppressor 1 Like 2 3 5
  • Breast Cancer Metastasis-Suppressor 1 2 3
  • BRMS1-Homolog Protein P40 3 4
  • BRMS1-Like Protein P40 3 4
  • Breast Cancer Metastasis-Suppressor 1-Like Protein 3
  • BRMS1 3

External Ids for BRMS1L Gene

Previous HGNC Symbols for BRMS1L Gene

  • BRMS1

Previous GeneCards Identifiers for BRMS1L Gene

  • GC14P034286
  • GC14P034287
  • GC14P035365
  • GC14P036295
  • GC14P016409

Summaries for BRMS1L Gene

Entrez Gene Summary for BRMS1L Gene

  • The protein encoded by this gene shows sequence similarity to the human breast carcinoma metastasis suppressor (BRMS1) protein and the mammalian Sds3 (suppressor of defective silencing 3) proteins. This protein is a component of the mSin3a family of histone deacetylase complexes (HDAC). [provided by RefSeq, Jul 2008]

GeneCards Summary for BRMS1L Gene

BRMS1L (Breast Cancer Metastasis-Suppressor 1 Like) is a Protein Coding gene. Diseases associated with BRMS1L include Breast Cancer. GO annotations related to this gene include histone deacetylase binding and histone deacetylase activity. An important paralog of this gene is BRMS1.

UniProtKB/Swiss-Prot for BRMS1L Gene

  • Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth.

Additional gene information for BRMS1L Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRMS1L Gene

Genomics for BRMS1L Gene

Regulatory Elements for BRMS1L Gene

Enhancers for BRMS1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H035856 0.8 ENCODE 12.3 +30.1 30131 0.8 PKNOX1 TBL1XR1 BACH1 BMI1 BATF RELA POLR2A EED ATF7 ZSCAN29 RALGAPA1 BRMS1L ENSG00000257272 ENSG00000258938
GH14H035825 1.1 ENCODE 0.7 +0.2 153 1.9 HDGF MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 RALGAPA1 DNAJC8P1 BRMS1L ENSG00000258938
GH14H035821 0.9 ENCODE 0.7 -4.3 -4269 0.2 ATF1 MLX ARID4B GTF3C2 SLC30A9 ZNF143 SP5 MIER2 PPARG KAT8 BRMS1L NUTF2P2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BRMS1L on UCSC Golden Path with GeneCards custom track

Promoters for BRMS1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000067677 -17 2200 HDGF MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9

Genomic Locations for BRMS1L Gene

Genomic Locations for BRMS1L Gene
106,008 bases
Plus strand

Genomic View for BRMS1L Gene

Genes around BRMS1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRMS1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRMS1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRMS1L Gene

Proteins for BRMS1L Gene

  • Protein details for BRMS1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Breast cancer metastasis-suppressor 1-like protein
    Protein Accession:
    Secondary Accessions:
    • A6NFW5
    • A6NH45
    • B2RD65
    • Q9BRI4

    Protein attributes for BRMS1L Gene

    323 amino acids
    Molecular mass:
    37629 Da
    Quaternary structure:
    • Component of the Sin3/HDAC1 corepressor complex at least composed of BRMS1, BRMS1L and ING2/ING1L. Interacts with HDAC and SIN3A.

    Alternative splice isoforms for BRMS1L Gene


neXtProt entry for BRMS1L Gene

Post-translational modifications for BRMS1L Gene

  • Ubiquitination at Lys76
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BRMS1L Gene

Domains & Families for BRMS1L Gene

Gene Families for BRMS1L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for BRMS1L Gene


Suggested Antigen Peptide Sequences for BRMS1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BRMS1 family.
  • Belongs to the BRMS1 family.
genes like me logo Genes that share domains with BRMS1L: view

Function for BRMS1L Gene

Molecular function for BRMS1L Gene

UniProtKB/Swiss-Prot Function:
Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth.

Gene Ontology (GO) - Molecular Function for BRMS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004407 contributes_to histone deacetylase activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0042826 histone deacetylase binding IBA --
genes like me logo Genes that share ontologies with BRMS1L: view

Phenotypes for BRMS1L Gene

genes like me logo Genes that share phenotypes with BRMS1L: view

Animal Model Products

miRNA for BRMS1L Gene

miRTarBase miRNAs that target BRMS1L

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BRMS1L Gene

Localization for BRMS1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRMS1L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BRMS1L gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for BRMS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0070822 Sin3-type complex IBA --
genes like me logo Genes that share ontologies with BRMS1L: view

Pathways & Interactions for BRMS1L Gene

SuperPathways for BRMS1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for BRMS1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016575 histone deacetylation IBA --
GO:0040008 regulation of growth IEA --
genes like me logo Genes that share ontologies with BRMS1L: view

No data available for Pathways by source and SIGNOR curated interactions for BRMS1L Gene

Drugs & Compounds for BRMS1L Gene

No Compound Related Data Available

Transcripts for BRMS1L Gene

Unigene Clusters for BRMS1L Gene

Breast cancer metastasis-suppressor 1-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BRMS1L Gene

No ASD Table

Relevant External Links for BRMS1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BRMS1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BRMS1L Gene

Protein differential expression in normal tissues from HIPED for BRMS1L Gene

This gene is overexpressed in Placenta (15.2), Retina (12.8), Fetal testis (9.6), Pancreas (8.5), and Prostate (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BRMS1L Gene

Protein tissue co-expression partners for BRMS1L Gene

NURSA nuclear receptor signaling pathways regulating expression of BRMS1L Gene:


SOURCE GeneReport for Unigene cluster for BRMS1L Gene:


Evidence on tissue expression from TISSUES for BRMS1L Gene

  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with BRMS1L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for BRMS1L Gene

Orthologs for BRMS1L Gene

This gene was present in the common ancestor of animals.

Orthologs for BRMS1L Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia BRMS1L 34
  • 100 (a)
LOC480292 33
  • 96.9 (n)
(Pan troglodytes)
Mammalia BRMS1L 33 34
  • 99.69 (n)
(Ornithorhynchus anatinus)
Mammalia BRMS1L 34
  • 99 (a)
(Monodelphis domestica)
Mammalia BRMS1L 34
  • 98 (a)
(Bos Taurus)
Mammalia BRMS1L 33 34
  • 96.08 (n)
-- 34
  • 93 (a)
(Rattus norvegicus)
Mammalia LOC100910898 33
  • 91.74 (n)
(Mus musculus)
Mammalia Brms1l 33 16 34
  • 90.71 (n)
(Gallus gallus)
Aves BRMS1L 33 34
  • 85.57 (n)
(Anolis carolinensis)
Reptilia BRMS1L 34
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia brms1l 33
  • 79.27 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.21343 33
(Danio rerio)
Actinopterygii brms1lb 34
  • 78 (a)
brms1la 33 34
  • 76.84 (n)
-- 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.443 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002712 33
  • 53.24 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4400 33 34
  • 47.66 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8326 34
  • 33 (a)
Species where no ortholog for BRMS1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRMS1L Gene

Gene Tree for BRMS1L (if available)
Gene Tree for BRMS1L (if available)

Paralogs for BRMS1L Gene

Paralogs for BRMS1L Gene

(3) SIMAP similar genes for BRMS1L Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with BRMS1L: view

Variants for BRMS1L Gene

Sequence variations from dbSNP and Humsavar for BRMS1L Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000037687 -- 35,842,601(+) GGCTG(C/T)CCTTA intron-variant
rs1000041286 -- 35,849,237(+) TGAAC(A/G)AGGGC intron-variant
rs1000142094 -- 35,839,537(+) CCTCT(C/T)TTATT intron-variant
rs1000185414 -- 35,834,438(+) GGTGG(C/G)GTATA intron-variant
rs1000237064 -- 35,846,334(+) GAGGC(C/T)GCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BRMS1L Gene

Variant ID Type Subtype PubMed ID
nsv1113635 CNV deletion 24896259
nsv564343 CNV loss 21841781
nsv84518 CNV deletion 16902084

Variation tolerance for BRMS1L Gene

Residual Variation Intolerance Score: 47.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BRMS1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRMS1L Gene

Disorders for BRMS1L Gene

MalaCards: The human disease database

(1) MalaCards diseases for BRMS1L Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for BRMS1L

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with BRMS1L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BRMS1L Gene

Publications for BRMS1L Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex. (PMID: 15451426) Nikolaev AY … Gu W (Biochemical and biophysical research communications 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60
  5. Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131. (PMID: 26841866) Varier RA … Vermeulen M (The Journal of biological chemistry 2016) 3 60

Products for BRMS1L Gene

Sources for BRMS1L Gene

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