Aliases for BRMS1L Gene
External Ids for BRMS1L Gene
Previous HGNC Symbols for BRMS1L Gene
Previous GeneCards Identifiers for BRMS1L Gene
The protein encoded by this gene shows sequence similarity to the human breast carcinoma metastasis suppressor (BRMS1) protein and the mammalian Sds3 (suppressor of defective silencing 3) proteins. This protein is a component of the mSin3a family of histone deacetylase complexes (HDAC). [provided by RefSeq, Jul 2008]
GeneCards Summary for BRMS1L Gene
BRMS1L (Breast Cancer Metastasis-Suppressor 1-Like) is a Protein Coding gene. Diseases associated with BRMS1L include breast cancer. Among its related pathways are Chromatin organization and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include histone deacetylase binding and histone deacetylase activity. An important paralog of this gene is SUDS3.
UniProtKB/Swiss-Prot for BRMS1L Gene
Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth.