BRMS1L Gene
protein-coding GIFtS: 47
GCID: GC14P036295
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breast cancer metastasis-suppressor 1-like(Previous name: breast cancer metastasis-suppressor 1 )
(Previous symbol: BRMS1)
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Aliases
for BRMS1L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Breast Cancer Metastasis-Suppressor 1-Like1 2 | | FLJ391771 | | BRMS11 2 | | MGC112961 | | BRMS1-Homolog Protein P402 3 | | Breast Cancer Metastasis-Suppressor 11 | | BRMS1-Like Protein P402 3 | | Breast Cancer Metastasis-Suppressor 1-Like Protein2 |
Export aliases for BRMS1L gene to outside databasesPrevious GC identifers: GC14P034286 GC14P034287 GC14P035365 GC14P016409 |
Summaries
for BRMS1L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for BRMS1L:
The protein encoded by this gene shows sequence similarity to the human breast carcinoma metastasis suppressor (BRMS1)protein and the mammalian Sds3 (suppressor of defective silencing 3) proteins. This protein is a component of themSin3a family of histone deacetylase complexes (HDAC). (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: BRM1L_HUMAN, Q5PSV4Function: Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressedin lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth
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Genomic Views
for BRMS1L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BRMS1L gene promoter:
TBP AML1a Nkx2-2 p300 E4BP4 C/EBPalpha AREB6 Pax-3 c-Myb Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for BRMS1L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BRMS1L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q13.2 Ensembl cytogenetic band: 14q13.2 HGNC cytogenetic band: 14q13.1BRMS1L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P036295: view genomic region
(about GC identifiers)
Start:
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36,295,524 bp from pter |
End:
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36,401,531 bp from pter |
Size:
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106,008 bases |
Orientation:
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plus strand |
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Proteins
for BRMS1L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BRM1L_HUMAN, Q5PSV4 (See
protein sequence)Recommended Name: Breast cancer metastasis-suppressor 1-like protein Size: 323 amino acids; 37629 Da
Subunit: Component of the Sin3/HDAC1 corepressor complex at least composed of BRMS1, BRMS1L and ING2/ING1L. Interactswith HDAC and SIN3A
Subcellular location: Nucleus (Probable)
Secondary accessions: A6NFW5 A6NH45 Q9BRI4Explore the universe of human proteins at neXtProt for BRMS1L: NX_Q5PSV4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5PSV4
BRMS1L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115728.2
ENSEMBL proteins: ENSP00000216807 ENSP00000448615 ENSP00000447022 ENSP00000446826 ENSP00000443781
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
BRMS1L for ontologies About GeneDecksing
BRMS1L Antibody Products:
Assay Products for BRMS1L: |
Protein
Domains /
Families
for BRMS1L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BRMS1L for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5PSV4ProtoNet protein and cluster: Q5PSV4 UniProtKB/Swiss-Prot: BRM1L_HUMAN, Q5PSV4Similarity: Belongs to the BRMS1 family |
Function
for BRMS1L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: BRM1L_HUMAN, Q5PSV4Function: Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressedin lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BRMS1L (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BRMS1L (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for BRMS1L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRMS1L |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRMS1L |
1 GenomeRNAi human phenotype for BRMS1L:
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Pathways & Interactions
for BRMS1L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BRMS1L
STRING Interaction
Network Preview (showing 5 interactants - click image to see 12)
5/13 Interacting proteins for BRMS1L (Q5PSV43 ENSP000002168074) via UniProtKB, MINT, STRING, and/or I2D (see all 13)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0040008 | regulation of growth |
IEA | -- |
BRMS1L for ontologies About GeneDecksing
|
Drugs & Compounds
for BRMS1L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BRMS1L
Search CenterWatch for drugs/clinical trials and news about BRMS1L / BRM1L
|
Transcripts
for BRMS1L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BRMS1L gene: NM_032352.3 Unigene Cluster for BRMS1L: Breast cancer metastasis-suppressor 1-like Hs.525299 [show with all ESTs]Unigene Representative Sequence: NM_0323527 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000216807(uc001wtl.3) ENST00000552677 ENST00000547420 ENST00000548758
ENST00000551774 ENST00000552849 ENST00000543183(uc010tpx.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BRMS1L (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BRMS1L (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: BRMS1L (NM_032352) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BRMS1L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRMS1L |
Additional cDNA sequence: AK096496.1 AK297106.1 AK309431.1 AK310359.1 AK315424.1 AY827074.1 BC006250.2 4 DOTS entries: DT.114699 DT.97835737 DT.91756015 DT.101968257 24/84 AceView cDNA sequences (see all 84): AW304325 AA974270 BQ723517 Z44923 BC006250 BI914436 BX452070 BU507838 BM673774 AI126358 Z41283 CR595618 AA461126 CR612796 CD677611 AA308885 AK096496 AI889479 AA745745 BQ071431 BX419113 CB151697 AI375921 Z45595
GeneLoc Exon Structure
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Expression
for BRMS1L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BRMS1L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTGGTCTTT
About this image
See BRMS1L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BRMS1L
SOURCE GeneReport for Unigene cluster: Hs.525299
SABiosciences Custom PCR Arrays for BRMS1L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BRMS1L
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BRMS1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BRMS1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BRMS1L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRMS1L |
Orthologs
for BRMS1L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for BRMS1L gene from 6/20 species (see all 20) About this table
ENSEMBL Gene Tree for BRMS1L (if available)
TreeFam Gene Tree for BRMS1L (if available) |
Paralogs
for BRMS1L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BRMS1L gene
- SUDS32 BRMS12
3 SIMAP similar genes for BRMS1L using alignment to 4 protein entries: BRM1L_HUMAN (see all proteins):DKFZp564A063 BRMS1 SUDS3
BRMS1L for paralogs About GeneDecksing
|
Genomic Variants
for BRMS1L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BRMS1L (36295524 - 36401531 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for BRMS1L
1 Indel: 11719 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BRMS1L |
|
Disorders
/ Diseases
for BRMS1L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BRMS1L for disorders About GeneDecksing
5  diseases for BRMS1L: About MalaCardsbreast cancer prader-willi syndrome breast carcinoma carcinoma
lung cancer
1 disease from the University of Copenhagen DISEASES database for BRMS1L:Breast cancer Export disorders for BRMS1L gene to outside databases
|
Publications
for BRMS1L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BRMS1L gene integrated from 9 sources:
(articles sorted by number of sources associating them with BRMS1L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex. (PubMed id 15451426)1, 2 Nikolaev A.Y.... Gu W. (2004)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. (PubMed id 16387653)1 Doyon Y.... Cote J. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for BRMS1L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing BRMS1L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BRMS1L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BRMS1L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for BRMS1L gene:
Search GeneIP for patents involving BRMS1L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BRMS1L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for BRMS1L | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BRMS1L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BRMS1L | | | OriGene Protein Over-expression Lysate for BRMS1L | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BRMS1L | | OriGene 3'-UTR Clone for BRMS1L | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BRMS1L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BRMS1L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BRMS1L | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BRMS1L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BRMS1L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BRMS1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BRMS1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BRMS1L |
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| | | | Search Tocris compounds for BRMS1L |
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 | | | BRMS1L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRMS1L |
|  |  |  | | | | ThermoFisher Antibodies for BRMS1L |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRMS1L |
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