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BRMS1L Gene

protein-coding   GIFtS: 50
GCID: GC14P036295

Breast Cancer Metastasis-Suppressor 1-Like

(Previous name: breast cancer metastasis-suppressor 1)
(Previous symbol: BRMS1)
  See BRMS1L-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Breast Cancer Metastasis-Suppressor 1-Like1 2
BRMS11 2
BRMS1-Homolog Protein P402 3
BRMS1-Like Protein P402 3
Breast Cancer Metastasis-Suppressor 11
Breast Cancer Metastasis-Suppressor 1-Like Protein2

External Ids:    HGNC: 205121   Entrez Gene: 843122   Ensembl: ENSG000001009167   UniProtKB: Q5PSV43   

Export aliases for BRMS1L gene to outside databases

Previous GC identifers: GC14P034286 GC14P034287 GC14P035365 GC14P016409


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BRMS1L Gene:
The protein encoded by this gene shows sequence similarity to the human breast carcinoma metastasis suppressor
(BRMS1) protein and the mammalian Sds3 (suppressor of defective silencing 3) proteins. This protein is a
component of the mSin3a family of histone deacetylase complexes (HDAC). (provided by RefSeq, Jul 2008)

GeneCards Summary for BRMS1L Gene:
BRMS1L (breast cancer metastasis-suppressor 1-like) is a protein-coding gene. Diseases associated with BRMS1L include breast cancer. An important paralog of this gene is SUDS3.

UniProtKB/Swiss-Prot: BRM1L_HUMAN, Q5PSV4
Function: Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When
overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BRMS1L gene promoter:
         TBP   AML1a   Nkx2-2   p300   E4BP4   C/EBPalpha   AREB6   Pax-3   c-Myb   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBRMS1L promoter sequence
   Search Chromatin IP Primers for BRMS1L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BRMS1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q13.2   Ensembl cytogenetic band:  14q13.2   HGNC cytogenetic band: 14q13.1

BRMS1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRMS1L gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P036295:  view genomic region     (about GC identifiers)

Start:
36,295,524 bp from pter      End:
36,401,531 bp from pter
Size:
106,008 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: BRM1L_HUMAN, Q5PSV4 (See protein sequence)
Recommended Name: Breast cancer metastasis-suppressor 1-like protein  
Size: 323 amino acids; 37629 Da
Subunit: Component of the Sin3/HDAC1 corepressor complex at least composed of BRMS1, BRMS1L and ING2/ING1L.
Interacts with HDAC and SIN3A
Secondary accessions: A6NFW5 A6NH45 Q9BRI4

Explore the universe of human proteins at neXtProt for BRMS1L: NX_Q5PSV4

Explore proteomics data for BRMS1L at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys76
  • Modification sites at PhosphoSitePlus

  • See BRMS1L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115728.2  
    ENSEMBL proteins: 
     ENSP00000216807   ENSP00000448615   ENSP00000447022   ENSP00000446826   ENSP00000443781  

    BRMS1L Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for BRMS1L

     
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    antibodies-online proteins for BRMS1L (5 products) 

     
    antibodies-online peptides for BRMS1L

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR013907 Sds3

    Graphical View of Domain Structure for InterPro Entry Q5PSV4

    ProtoNet protein and cluster: Q5PSV4

    UniProtKB/Swiss-Prot: BRM1L_HUMAN, Q5PSV4
    Similarity: Belongs to the BRMS1 family


    Find genes that share domains with BRMS1L           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BRM1L_HUMAN, Q5PSV4
    Function: Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When
    overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth

    Phenotypes:
         1 GenomeRNAi human phenotype for BRMS1L:

     Increased ID2::GFP protein exp 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for BRMS1L

    miRNA
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    miRTarBase miRNAs that target BRMS1L:
    hsa-mir-181a-5p (MIRT025127), hsa-mir-106b-5p (MIRT020480), hsa-mir-196a-5p (MIRT048172), hsa-mir-142-3p (MIRT021608)

    Block miRNA regulation of human, mouse, rat BRMS1L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BRMS1L (see all 28):
    hsa-miR-875-3p hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-302e hsa-miR-519a hsa-miR-223 hsa-miR-520a-3p
    SwitchGear 3'UTR luciferase reporter plasmidBRMS1L 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat BRMS1L

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BRM1L_HUMAN, Q5PSV4: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with BRMS1L           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BRMS1L
    Interactions:

        Search GeneGlobe Interaction Network for BRMS1L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BRMS1L (Q5PSV43 ENSP000002168074) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RBBP4Q090283, ENSP000003625924I2D: score=1 STRING: ENSP00000362592
    RBBP7Q165763, ENSP000003694274I2D: score=1 STRING: ENSP00000369427
    SAP30O754463, ENSP000002965044I2D: score=1 STRING: ENSP00000296504
    HDAC1Q135473, ENSP000003626494I2D: score=1 STRING: ENSP00000362649
    ING1Q9UK533, ENSP000003649294I2D: score=1 STRING: ENSP00000364929
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0040008regulation of growth IEA--

    Find genes that share ontologies with BRMS1L           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BRMS1L (BRM1L)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BRMS1L gene: 
    NM_032352.3  

    Unigene Cluster for BRMS1L:

    Breast cancer metastasis-suppressor 1-like
    Hs.525299  [show with all ESTs]
    Unigene Representative Sequence: NM_032352
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216807(uc001wtl.3) ENST00000552677 ENST00000547420 ENST00000548758
    ENST00000551774 ENST00000552849 ENST00000543183(uc010tpx.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat BRMS1L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BRMS1L (see all 28):
    hsa-miR-875-3p hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-302e hsa-miR-519a hsa-miR-223 hsa-miR-520a-3p
    SwitchGear 3'UTR luciferase reporter plasmidBRMS1L 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat BRMS1L
      QuantiFast Probe-based Assays in human, mouse, rat BRMS1L

    Additional mRNA sequence: 

    AK096496.1 AK297106.1 AK309431.1 AK310359.1 AK315424.1 AY827074.1 BC006250.2 

    4 DOTS entries:

    DT.114699  DT.97835737  DT.91756015  DT.101968257 

    Selected AceView cDNA sequences (see all 84):

    BM673774 CR595618 AI375921 BU507838 CB151697 BI914436 BQ071431 Z41283 
    AA974270 AA448679 BM712928 AI889479 AA461126 AA745745 AI126358 AW203996 
    BM986833 BC006250 Z45595 CR612796 BX419113 CD677611 BQ723517 NM_032352 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BRMS1L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGGTCTTT
    BRMS1L Expression
    About this image

    BRMS1L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BRMS1L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.525299
        Custom PCR Arrays for BRMS1L
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BRMS1L gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Brms1l1 , 5 breast cancer metastasis-suppressor 1-like1, 5 90.71(n)1
    99.69(a)1
      12 (24.18 cM)5
    525921  NM_001037756.21  NP_001032845.11 
     558363665 
    chicken
    (Gallus gallus)
    Aves BRMS1L1 breast cancer metastasis-suppressor 1-like 85.57(n)
    95.33(a)
      423328  NM_001007935.1  NP_001007936.1 
    lizard
    (Anolis carolinensis)
    Reptilia BRMS1L6
    breast cancer metastasis-suppressor 1-like
    77(a)
    1 ↔ 1
    1(24178761-24205903)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.213432 Xenopus laevis transcribed sequence with weak similarity more 77.14(n)    CA787714.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC049431.12   -- 73.1(n)   368897  BC049431.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG44001 CG4400 47.66(n)
    41.63(a)
      32243  NM_132612.1  NP_572840.1 


    ENSEMBL Gene Tree for BRMS1L (if available)
    TreeFam Gene Tree for BRMS1L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BRMS1L gene
    SUDS32  BRMS12  
    3 SIMAP similar genes for BRMS1L using alignment to 4 protein entries:     BRM1L_HUMAN (see all proteins):
    DKFZp564A063    BRMS1    SUDS3

    Find genes that share paralogs with BRMS1L           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BRMS1L (see all 914)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1899740681,2
    C--36293828(+) TGGCCA/GGGCGG 1 -- us2k10--------
    rs1823394351,2
    C--36294100(+) GAGGGG/TCTCCT 1 -- us2k10--------
    rs1485832421,2
    C--36294570(+) GATCAC/TTCGCG 1 -- us2k10--------
    rs1429990941,2
    C--36294574(+) ATTCGC/TGGTTA 1 -- us2k10--------
    rs1852019221,2
    --36294758(+) CGGCTA/CGGCAT 1 -- us2k10--------
    rs1132446471,2
    C,F--36294957(+) AAAAAG/ATAAAT 1 -- us2k12Minor allele frequency- A:0.33CSA 3
    rs1910451001,2
    --36294991(+) GCCAAA/GATAAA 1 -- us2k10--------
    rs1838886471,2
    --36295060(+) CACAGA/TAAGTG 1 -- us2k10--------
    rs1398382261,2
    C--36295428(+) ACCTAA/CGAACT 1 -- us2k10--------
    rs1153461421,2
    C,F--36295674(+) GCGGCG/AGTGGC 1 -- ut511Minor allele frequency- A:0.07WA 118

    HapMap Linkage Disequilibrium report for BRMS1L (36295524 - 36401531 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for BRMS1L:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv901631CNV Loss21882294
    dgv1874n71CNV Loss21882294
    nsv84518CNV Loss16902084
    nsv901627CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BRMS1L
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for BRMS1L:    
    About MalaCards
    breast cancer

    1 disease from the University of Copenhagen DISEASES database for BRMS1L:
    Breast cancer

    Find genes that share disorders with BRMS1L           About GenesLikeMe

    Genetic Association Database (GAD): BRMS1L

    Export disorders for BRMS1L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BRMS1L gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with BRMS1L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex. (PubMed id 15451426)1, 2 Nikolaev A.Y.... Gu W. (Biochem. Biophys. Res. Commun. 2004)
    2. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    3. Discovery of common variants associated with low TSH levels and thyroid cancer risk. (PubMed id 22267200)4 Gudmundsson J....Stefansson K. (Nat. Genet. 2012)
    4. Association between single nucleotide polymorphism-genotype and outcome of patients with chronic lymphocytic leukemia in a randomized chemotherapy trial. (PubMed id 21659360)4 Wade R....Houlston R.S. (Haematologica 2011)
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    6. System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (Sci Signal 2009)
    7. Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations. (PubMed id 19198613)4 Gudmundsson J....Stefansson K. (Nat. Genet. 2009)
    8. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    10. Genome-wide association of sleep and circadian phenotypes. (PubMed id 17903308)4 Gottlieb D.J....Wilk J.B. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84312 HGNC: 20512 AceView: BRMS1L Ensembl:ENSG00000100916 euGenes: HUgn84312
    ECgene: BRMS1L H-InvDB: BRMS1L

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BRMS1L Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BRMS1L Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BRMS1L gene:
    Search GeneIP for patents involving BRMS1L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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