External Ids for BRMS1 Gene
Previous GeneCards Identifiers for BRMS1 Gene
This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for BRMS1 Gene
BRMS1 (Breast Cancer Metastasis Suppressor 1) is a Protein Coding gene. Diseases associated with BRMS1 include Breast Cancer and Malignant Melanoma, Somatic. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Chromatin organization. GO annotations related to this gene include histone deacetylase binding and histone deacetylase activity. An important paralog of this gene is BRMS1L.
UniProtKB/Swiss-Prot for BRMS1 Gene
Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at Lys-310. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.