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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BRMS1 Gene

protein-coding GIFtS: 55
GCID: GC11M066104

breast cancer metastasis suppressor 1

Explore 13 diseases affiliated with
BRMS1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Breast Cancer Metastasis Suppressor 1¹ ²
DKFZP564A063¹
Breast Cancer Metastasis-Suppressor 1²

External Ids:	HGNC: 17262¹	Entrez Gene: 25855²	Ensembl: ENSG00000174744⁷	OMIM: 606259⁵	UniProtKB: Q9HCU9³

Export aliases for BRMS1 gene to outside databases

Previous GC identifers: GC11M068638 GC14P030082 GC14P034285 GC11M065881 GC11M065882 GC11M065861 GC11M062437

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BRMS1:

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines.

The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone

deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs.

Alternative splicing results in two transcript variants encoding different isoforms. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: BRMS1_HUMAN, Q9HCU9

Function: Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the

deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of

anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to

a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression

in breast carcinoma

Gene Wiki entry for BRMS1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BRMS1 gene promoter:
AP-1 ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BRMS1 promoter sequence

Search SABiosciences Chromatin IP Primers for BRMS1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BRMS1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13-q13.2 Ensembl cytogenetic band: 11q13.2 HGNC cytogenetic band: 11q13-q13.2

BRMS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRMS1 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M066104: view genomic region (about GC identifiers)

Start:	66,104,804 bp from pter	End:	66,112,596 bp from pter
Size:	7,793 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BRMS1_HUMAN, Q9HCU9 (See protein sequence)

Recommended Name: Breast cancer metastasis-suppressor 1

Size: 246 amino acids; 28461 Da

Subunit: Interacts with SNX6, HDAC1 and RELA. Interacts with ARID4A. Identified in mSin3A corepressor complexes

together with SIN3A, SIN3B, RBBP4, RBBP7, SAP30, SUDS3, ARID4A, HDAC1 and HDAC2

Subcellular location: Nucleus. Cytoplasm. Note=Predominantly nuclear

1 PDB 3D structure from and Proteopedia for BRMS1:

2XUS (3D)

Secondary accessions: Q6IAI2

Explore the universe of human proteins at neXtProt for BRMS1: NX_Q9HCU9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9HCU9

BRMS1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001020128.1 NP_056214.1

ENSEMBL proteins:

ENSP00000396052 ENSP00000431510 ENSP00000353042 ENSP00000434591 ENSP00000433740

Human Recombinant Protein Products:

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	Novus Biologicals BRMS1 Protein Novus Biologicals BRMS1 Lysates
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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for BRMS1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	17000776
GO:0005737	cytoplasm	IDA	--

BRMS1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for BRMS1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BRMS1 for domains About GeneDecksing

1 InterPro domain/family:

IPR013907 Sds3

Graphical View of Domain Structure for InterPro Entry Q9HCU9

ProtoNet protein and cluster: Q9HCU9

1 Blocks protein family: IPB013907 Sds3-like

UniProtKB/Swiss-Prot: BRMS1_HUMAN, Q9HCU9

Similarity: Belongs to the BRMS1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: BRMS1_HUMAN, Q9HCU9

Function: Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the

deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of

anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to

a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression

in breast carcinoma

miRNA Products:		OriGene 3'-UTR Clone (see all 2): BRMS1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BRMS1
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate BRMS1:
		hsa-miR-4251 hsa-miR-149 hsa-miR-145
		SwitchGear 3'UTR luciferase reporter plasmid: BRMS1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BRMS1 (see all 7) OriGene shRNA RFP: BRMS1 OriGene siRNA: BRMS1
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Gene Editing
Products:

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRMS1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0051059	NF-kappaB binding	IDA	17000776

BRMS1 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for BRMS1:

Increased S DNA content

Increased number of cells in m

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for BRMS1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/38 Interacting proteins for BRMS1 (Q9HCU9^{1, 2, 3} ENSP00000396052⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 38)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GOLGB1	Q14789²^,³, ENSP00000341848⁴	MINT-64181 I2D: score=4 STRING: ENSP00000341848
DNAJB6	O75190¹^,³, ENSP00000262177⁴	EBI-714781,EBI-1053164 I2D: score=2 STRING: ENSP00000262177
HDAC4	P56524¹^,³, ENSP00000264606⁴	EBI-714781,EBI-308629 I2D: score=2 STRING: ENSP00000264606
HDAC6	Q9UBN7¹^,³, ENSP00000334061⁴	EBI-714781,EBI-301697 I2D: score=2 STRING: ENSP00000334061
NMI	Q13287¹^,³, ENSP00000243346⁴	EBI-714781,EBI-372942 I2D: score=2 STRING: ENSP00000243346

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006915	apoptotic process	IEA	--
GO:0009987	cellular process	--	--
GO:0019987	negative regulation of anti-apoptosis	--	--
GO:0032088	negative regulation of NF-kappaB transcription factor activity	IDA	17000776

BRMS1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for BRMS1
Search CenterWatch for drugs/clinical trials and news about BRMS1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for BRMS1 gene (3 alternative transcripts):

NM_001024957.1 NM_015399.3 NM_001024958.1

Unigene Cluster for BRMS1:

Breast cancer metastasis suppressor 1

Hs.100426 [show with all ESTs]

Unigene Representative Sequence: BM472938

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000425825(uc001oho.1) ENST00000524699 ENST00000359957(uc001ohp.1)

ENST00000530238(uc009yre.3) ENST00000527375 ENST00000530756 ENST00000534617

ENST00000525127 ENST00000529544

miRNA Products:		OriGene 3'-UTR Clone (see all 2): BRMS1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BRMS1
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate BRMS1:
		hsa-miR-4251 hsa-miR-149 hsa-miR-145
		SwitchGear 3'UTR luciferase reporter plasmid: BRMS1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AF147350.1 AF159141.1 AK310991.1 AK313773.1 AL050008.1 BC009834.2 CR457173.1

13 DOTS entries:

DT.92434986 DT.203143 DT.100020596 DT.95073095 DT.95073094 DT.120734057 DT.100020597 DT.95073092

DT.100793535 DT.95073093 DT.95073096 DT.95154811 DT.100754044

24/178 AceView cDNA sequences (see all 178):

CA487347 BF531086 AW250439 BQ681248 CB131446 BU538881 CR617084 BU146806

BF037901 AW732306 BQ059745 BI836574 CR620200 BG166370 BQ674777 BU838210

BM014765 CA454165 AI804766 BE792276 CR618839 BQ069890 CB215122 CR599820

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for BRMS1 (see all 6) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11a	·	11b
SP1:			-
SP2:			-										-
SP3:																									-
SP4:			-
SP5:			-

ECgene alternative splicing isoforms for BRMS1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BRMS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTCAAGAGA

About this image
See BRMS1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BRMS1

SOURCE GeneReport for Unigene cluster: Hs.100426

UniProtKB/Swiss-Prot: BRMS1_HUMAN, Q9HCU9

Tissue specificity: Expression levels are higher in term placentas than in early placentas. Low levels of expression

observed in normal pregnancies and in molar pregnancies

SABiosciences Expression via Pathway-Focused PCR Array including BRMS1:

Tumor Metastasis in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRMS1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for BRMS1 gene from 2/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
zebrafish (Danio rerio)	Actinopterygii	brms1¹	breast cancer metastasis-suppressor 1	62.16(n) 60.25(a)		791681 NM_200097.1 NP_956391.1
fruit fly (Drosophila melanogaster)	Insecta	CG4400³	--	43(a)		11D1 --

ENSEMBL Gene Tree for BRMS1 (if available)
TreeFam Gene Tree for BRMS1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for BRMS1 gene

SUDS3² BRMS1L²

2 SIMAP similar genes for BRMS1 using alignment to 5 protein entries: BRMS1_HUMAN (see all proteins):

DKFZp564A063 BRMS1L

BRMS1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs139958271^1,2		--	66106090(+)	`GGAAGC/GCTTGG`	2	--	int¹		0	--	--	--	--
rs202104439^1,2		--	66106171(+)	`GTCACG/TTGGGC`	2	--	int¹		0	--	--	--	--
rs201048077^1,2		--	66106186(+)	`GCGGCA/CCCCAC`	2	--	int¹		0	--	--	--	--
rs143489952^1,2	C,F,	--	66106261(+)	`CCTGTG/AGTGGG`	2	--	int¹		1		EU	1323
rs200273840^1,2		--	66106294(+)	`TGGCAC/GGTGAC`	2	--	int¹		0	--	--	--	--
rs185282925^1,2		--	66106426(+)	`GGGGTC/TGTCCT`	2	--	int¹		0	--	--	--	--
rs145438803^1,2		--	66106432(+)	`GTCCTA/GGAACC`	2	--	int¹		0	--	--	--	--
rs148834320^1,2		--	66106529(+)	`CTCACA/TCTGCA`	2	--	int¹		0	--	--	--	--
rs142560218^1,2		--	66106538(+)	`CAGCAC/TTGGCC`	2	--	int¹		0	--	--	--	--
rs190038152^1,2		--	66106578(+)	`CAGACA/GCAGGG`	2	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for BRMS1 (66104804 - 66112596 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BRMS1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BRMS1

DNA2.0 Custom Variant and Variant Library Synthesis for BRMS1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

BRMS1 for disorders           About GeneDecksing

OMIM gene information: 606259    OMIM disorders: --

13 diseases for BRMS1:    About MalaCards

breast cancer melanoma intrahepatic cholangiocarcinoma laryngitis

laryngeal carcinoma melanoma metastasis breast carcinoma cholangiocarcinoma

ovarian carcinoma carcinoma retinoblastoma lung cancer

schizophrenia

1 disease from the University of Copenhagen DISEASES database for BRMS1:

Breast cancer

8 Novoseek disease relationships for BRMS1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
breast carcinoma	60.6	8	11827072 (4), 11822878 (1), 11774238 (1), 11280719 (1) (see all 5)
primary tumor	51.7	2	15592684 (1), 16681721 (1)
breast cancer metastatic	50.4	1	15252837 (1)
metastasis	49.2	28	11822878 (5), 16681721 (5), 11827072 (4), 15592684 (2) (see all 9)
breast cancer	45.7	13	15592684 (3), 16681721 (3), 15252837 (2), 11822878 (1) (see all 6)
melanoma	34.7	10	11822878 (4), 16681721 (3)
tumors	11.2	14	11822878 (3), 16681721 (3), 11827072 (1), 17896182 (1)
carcinoma	10.7	2	15252837 (1)

Export disorders for BRMS1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for BRMS1 gene, integrated from 9 sources (see all 60):
(articles sorted by number of sources associating them with BRMS1)

Utopia: connect your pdf to the dynamic
world of online information

Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13. (PubMed id 10850410)^{1, 2, 3} Seraj M.J.... Welch D.R. (2000)
Sorting nexin 6 interacts with breast cancer metastasis suppressor-1 and promotes transcriptional repression. (PubMed id 20830743)^{1, 2} Rivera J.... Bravo J. (2010)
Breast cancer metastasis suppressor 1 functions as a corepressor by enhancing histone deacetylase 1-mediated deacetylation of RelA/p 65 and promoting apoptosis. (PubMed id 17000776)^{1, 2} Liu Y....Jones D.R. (2006)
Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription. (PubMed id 14581478)^{1, 2} Meehan W.J....Welch D.R. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells. (PubMed id 12414911)^{1, 2} Janneau J.-L.... Bellet D. (2002)
Suppression of human melanoma metastasis by the metastasis suppressor gene, BRMS1. (PubMed id 11822878)^{1, 9} Shevde L.A....Welch D.R. (2002)
Identification and characterization of the murine ortholog (brms1) of breast-cancer metastasis suppressor 1 (BRMS1). (PubMed id 11774238)^{1, 9} Samant R.S....Welch D.R. (2002)
Microarray analysis reveals potential mechanisms of BRMS1-mediated metastasis suppression. (PubMed id 17896182)^{1, 9} Champine P.J....DeWald D.B. (2007)
Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases. (PubMed id 15592684)^{1, 9} Stark A.M....Held-Feindt J. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 25855	HGNC: 17262	AceView: BRMS1	Ensembl:ENSG00000174744	euGenes: HUgn25855
ECgene: BRMS1	H-InvDB: BRMS1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for BRMS1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for BRMS1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for BRMS1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for BRMS1 gene:
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breast cancer metastasis suppressor 1

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breast cancer metastasis suppressor 1

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