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Aliases for BRMS1 Gene

Aliases for BRMS1 Gene

  • Breast Cancer Metastasis Suppressor 1 2 3

External Ids for BRMS1 Gene

Previous GeneCards Identifiers for BRMS1 Gene

  • GC11M068638
  • GC14P030082
  • GC14P034285
  • GC11M065881
  • GC11M065882
  • GC11M065861
  • GC11M066104
  • GC11M062437

Summaries for BRMS1 Gene

Entrez Gene Summary for BRMS1 Gene

  • This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for BRMS1 Gene

BRMS1 (Breast Cancer Metastasis Suppressor 1) is a Protein Coding gene. Diseases associated with BRMS1 include breast cancer and melanoma. GO annotations related to this gene include NF-kappaB binding. An important paralog of this gene is BRMS1L.

UniProtKB/Swiss-Prot for BRMS1 Gene

  • Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at Lys-310. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.

Gene Wiki entry for BRMS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRMS1 Gene

Genomics for BRMS1 Gene

Regulatory Elements for BRMS1 Gene

Transcription factor binding sites by QIAGEN in the BRMS1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BRMS1 Gene

Start:
66,337,333 bp from pter
End:
66,345,125 bp from pter
Size:
7,793 bases
Orientation:
Minus strand

Genomic View for BRMS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BRMS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRMS1 Gene

Proteins for BRMS1 Gene

  • Protein details for BRMS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCU9-BRMS1_HUMAN
    Recommended name:
    Breast cancer metastasis-suppressor 1
    Protein Accession:
    Q9HCU9
    Secondary Accessions:
    • Q6IAI2

    Protein attributes for BRMS1 Gene

    Size:
    246 amino acids
    Molecular mass:
    28461 Da
    Quaternary structure:
    • Homohexamer (Potential). Interacts with SNX6, HDAC1 and RELA. Interacts with ARID4A. Identified in mSin3A corepressor complexes together with SIN3A, SIN3B, RBBP4, RBBP7, SAP30, SUDS3, ARID4A, HDAC1 and HDAC2. Interacts with SPOP; this recruits the protein to a ubiquitin ligase complex containing SPOP and CUL3.

    Three dimensional structures from OCA and Proteopedia for BRMS1 Gene

neXtProt entry for BRMS1 Gene

Proteomics data for BRMS1 Gene at MOPED

Post-translational modifications for BRMS1 Gene

  • Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing SPOP, leading to proteasomal degradation.
  • Ubiquitination at Lys123
  • Modification sites at PhosphoSitePlus

Other Protein References for BRMS1 Gene

Antibody Products

No data available for DME Specific Peptides for BRMS1 Gene

Domains for BRMS1 Gene

Protein Domains for BRMS1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for BRMS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HCU9

UniProtKB/Swiss-Prot:

BRMS1_HUMAN :
  • Q9HCU9
Domain:
  • Contains an N-terminal anti-parallel coiled coil formed by two BRMS1 chains; this region can form homohexamers
Family:
  • Belongs to the BRMS1 family.
genes like me logo Genes that share domains with BRMS1: view

No data available for Gene Families for BRMS1 Gene

Function for BRMS1 Gene

Molecular function for BRMS1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at Lys-310. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.

Gene Ontology (GO) - Molecular Function for BRMS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004407 contributes_to histone deacetylase activity IBA --
GO:0005515 protein binding IPI 16919237
GO:0042826 histone deacetylase binding IBA --
GO:0051059 NF-kappaB binding IDA 17000776
genes like me logo Genes that share ontologies with BRMS1: view
genes like me logo Genes that share phenotypes with BRMS1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BRMS1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BRMS1 Gene

Localization for BRMS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRMS1 Gene

Nucleus. Cytoplasm. Note=Predominantly nuclear.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BRMS1 Gene COMPARTMENTS Subcellular localization image for BRMS1 gene
Compartment Confidence
nucleus 5
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for BRMS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17000776
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 20830743
GO:0070822 Sin3-type complex IBA --
genes like me logo Genes that share ontologies with BRMS1: view

Pathways for BRMS1 Gene

SuperPathways for BRMS1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for BRMS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
GO:0009987 cellular process --
genes like me logo Genes that share ontologies with BRMS1: view

No data available for Pathways by source for BRMS1 Gene

Transcripts for BRMS1 Gene

Unigene Clusters for BRMS1 Gene

Breast cancer metastasis suppressor 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BRMS1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BRMS1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: -
SP2: - -
SP3: -
SP4: -
SP5: -
SP6:

Relevant External Links for BRMS1 Gene

GeneLoc Exon Structure for
BRMS1
ECgene alternative splicing isoforms for
BRMS1

Expression for BRMS1 Gene

mRNA expression in normal human tissues for BRMS1 Gene

Protein differential expression in normal tissues for BRMS1 Gene

This gene is overexpressed in Lung (23.9), Pancreas (10.0), CD8 Tcells (8.6), and Blymphocyte (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BRMS1 Gene

SOURCE GeneReport for Unigene cluster for BRMS1 Gene Hs.100426

mRNA Expression by UniProt/SwissProt for BRMS1 Gene

Q9HCU9-BRMS1_HUMAN
Tissue specificity: Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies.
genes like me logo Genes that share expressions with BRMS1: view

Expression partners for BRMS1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for BRMS1 Gene

Orthologs for BRMS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for BRMS1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BRMS1 35
  • 91.39 (n)
  • 97.13 (a)
BRMS1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BRMS1 35
  • 92.49 (n)
  • 95.9 (a)
BRMS1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Brms1 35
  • 89.07 (n)
  • 92.62 (a)
Brms1 16
Brms1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BRMS1 35
  • 99.66 (n)
  • 99.66 (a)
BRMS1 36
  • 100 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii brms1 35
  • 61.2 (n)
  • 59.43 (a)
brms1 36
  • 43 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4400 37
  • 43 (a)
CG4400 36
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8326 36
  • 24 (a)
OneToMany
Species with no ortholog for BRMS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRMS1 Gene

ENSEMBL:
Gene Tree for BRMS1 (if available)
TreeFam:
Gene Tree for BRMS1 (if available)

Paralogs for BRMS1 Gene

Paralogs for BRMS1 Gene

Selected SIMAP similar genes for BRMS1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with BRMS1: view

Variants for BRMS1 Gene

Sequence variations from dbSNP and Humsavar for BRMS1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs947977 -- 66,340,451(+) ATGAC(A/G)ACAAT intron-variant
rs947978 -- 66,341,189(+) GGGTA(C/T)AGAAC intron-variant
rs948359 -- 66,340,479(-) GTTCA(C/T)GTGGA intron-variant
rs948360 -- 66,339,254(-) TCATT(A/G)TGGCA intron-variant
rs1320675 -- 66,339,230(-) GAGCA(G/T)GCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BRMS1 Gene

Variant ID Type Subtype PubMed ID
dgv1187n71 CNV Loss 21882294
nsv897772 CNV Loss 21882294
dgv1189n71 CNV Loss 21882294
nsv897783 CNV Loss 21882294
dgv1190n71 CNV Loss 21882294

Relevant External Links for BRMS1 Gene

HapMap Linkage Disequilibrium report
BRMS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRMS1 Gene

Disorders for BRMS1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for BRMS1 Gene in MalaCards »

(2) Diseases for BRMS1 Gene including...

(1) University of Copenhagen DISEASES for BRMS1 Gene

(8) Novoseek inferred disease relationships for BRMS1 Gene

Disease -log(P) Hits PubMed IDs
breast carcinoma 60.6 8
primary tumor 51.7 2
breast cancer metastatic 50.4 1
metastasis 49.2 22
breast cancer 45.7 11
genes like me logo Genes that share disorders with BRMS1: view

No data available for OMIM , UniProtKB/Swiss-Prot , Genatlas and External Links for BRMS1 Gene

Publications for BRMS1 Gene

  1. Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13. (PMID: 10850410) Seraj M.J. … Welch D.R. (Cancer Res. 2000) 2 3 4
  2. Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells. (PMID: 12414911) Janneau J.-L. … Bellet D. (J. Clin. Endocrinol. Metab. 2002) 3 4
  3. Microarray analysis reveals potential mechanisms of BRMS1-mediated metastasis suppression. (PMID: 17896182) Champine P.J. … DeWald D.B. (Clin. Exp. Metastasis 2007) 3 23
  4. Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription. (PMID: 14581478) Meehan W.J. … Welch D.R. (J. Biol. Chem. 2004) 3 4
  5. Identification and characterization of the murine ortholog (brms1) of breast-cancer metastasis suppressor 1 (BRMS1). (PMID: 11774238) Samant R.S. … Welch D.R. (Int. J. Cancer 2002) 3 23

Products for BRMS1 Gene

Sources for BRMS1 Gene

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