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Aliases for BRMS1 Gene

Aliases for BRMS1 Gene

  • Breast Cancer Metastasis Suppressor 1 2 3 5

External Ids for BRMS1 Gene

Previous GeneCards Identifiers for BRMS1 Gene

  • GC11M068638
  • GC14P030082
  • GC14P034285
  • GC11M065881
  • GC11M065882
  • GC11M065861
  • GC11M066104
  • GC11M062437

Summaries for BRMS1 Gene

Entrez Gene Summary for BRMS1 Gene

  • This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for BRMS1 Gene

BRMS1 (Breast Cancer Metastasis Suppressor 1) is a Protein Coding gene. Diseases associated with BRMS1 include Breast Cancer and Malignant Melanoma, Somatic. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Chromatin organization. GO annotations related to this gene include histone deacetylase binding and histone deacetylase activity. An important paralog of this gene is BRMS1L.

UniProtKB/Swiss-Prot for BRMS1 Gene

  • Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at Lys-310. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.

Gene Wiki entry for BRMS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRMS1 Gene

Genomics for BRMS1 Gene

Regulatory Elements for BRMS1 Gene

Enhancers for BRMS1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F065414 1.4 FANTOM5 ENCODE 21.1 +920.9 920944 18.8 CREB3L1 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 NEAT1 ZFPL1 KAT5 EIF1AD LOC105369352 POLA2 MUS81 PCNX3 FRMD8 ENSG00000255320
GH11F066191 0.2 ENCODE 20.7 +153.4 153411 0.2 KLF1 DPF2 GATAD2B KLF4 GTF3C2 SREBF1 GATA3 ZNF316 POLR3A SCRT2 ENSG00000255320 EIF1AD KAT5 BRMS1 ENSG00000255038 PCNX3 ENSG00000258297 FRMD8 RBM14 POLA2
GH11F065851 0.7 ENCODE 20.4 +487.6 487641 12.2 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 SNX32 EIF1AD ZFPL1 PCNX3 POLA2 MRPL11 FRMD8 ENSG00000258297 NEAT1 ENSG00000255320
GH11F066342 1.5 FANTOM5 Ensembl ENCODE 11.9 -3.4 -3420 11.8 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 ENSG00000258297 RBM14 RIN1 MRPL11 SSSCA1-AS1 EIF1AD RCE1 LOC105369352 CD248 ACTN3
GH11F066311 1.5 FANTOM5 ENCODE 11.4 +29.8 29792 8.3 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 YBX1 RIN1 CTSW BRMS1 TMEM151A YIF1A LOC102724064 ENSG00000255320 PACS1 ENSG00000254458 CD248
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around BRMS1 on UCSC Golden Path with GeneCards custom track

Promoters for BRMS1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001604391 325 1201 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 ZNF143

Genomic Location for BRMS1 Gene

Chromosome:
11
Start:
66,337,333 bp from pter
End:
66,345,125 bp from pter
Size:
7,793 bases
Orientation:
Minus strand

Genomic View for BRMS1 Gene

Genes around BRMS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRMS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRMS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRMS1 Gene

Proteins for BRMS1 Gene

  • Protein details for BRMS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCU9-BRMS1_HUMAN
    Recommended name:
    Breast cancer metastasis-suppressor 1
    Protein Accession:
    Q9HCU9
    Secondary Accessions:
    • Q6IAI2

    Protein attributes for BRMS1 Gene

    Size:
    246 amino acids
    Molecular mass:
    28461 Da
    Quaternary structure:
    • Homohexamer (Potential). Interacts with SNX6, HDAC1 and RELA. Interacts with ARID4A. Identified in mSin3A corepressor complexes together with SIN3A, SIN3B, RBBP4, RBBP7, SAP30, SUDS3, ARID4A, HDAC1 and HDAC2. Interacts with SPOP; this recruits the protein to a ubiquitin ligase complex containing SPOP and CUL3.

    Three dimensional structures from OCA and Proteopedia for BRMS1 Gene

neXtProt entry for BRMS1 Gene

Post-translational modifications for BRMS1 Gene

  • Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing SPOP, leading to proteasomal degradation.
  • Ubiquitination at Lys 123
  • Modification sites at PhosphoSitePlus

Other Protein References for BRMS1 Gene

No data available for DME Specific Peptides for BRMS1 Gene

Domains & Families for BRMS1 Gene

Protein Domains for BRMS1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for BRMS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HCU9

UniProtKB/Swiss-Prot:

BRMS1_HUMAN :
  • Contains an N-terminal anti-parallel coiled coil formed by two BRMS1 chains; this region can form homohexamers.
  • Belongs to the BRMS1 family.
Domain:
  • Contains an N-terminal anti-parallel coiled coil formed by two BRMS1 chains; this region can form homohexamers.
Family:
  • Belongs to the BRMS1 family.
genes like me logo Genes that share domains with BRMS1: view

No data available for Gene Families for BRMS1 Gene

Function for BRMS1 Gene

Molecular function for BRMS1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at Lys-310. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.

Gene Ontology (GO) - Molecular Function for BRMS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004407 histone deacetylase activity TAS --
GO:0005515 protein binding IPI 16919237
GO:0042826 histone deacetylase binding IBA --
GO:0051059 NF-kappaB binding IDA 17000776
genes like me logo Genes that share ontologies with BRMS1: view
genes like me logo Genes that share phenotypes with BRMS1: view

Animal Models for BRMS1 Gene

MGI Knock Outs for BRMS1:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BRMS1 Gene

Localization for BRMS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRMS1 Gene

Nucleus. Cytoplasm. Note=Predominantly nuclear.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BRMS1 Gene COMPARTMENTS Subcellular localization image for BRMS1 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 1

Gene Ontology (GO) - Cellular Components for BRMS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 17000776
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA 20830743
GO:0070822 Sin3-type complex IBA --
genes like me logo Genes that share ontologies with BRMS1: view

Pathways & Interactions for BRMS1 Gene

genes like me logo Genes that share pathways with BRMS1: view

Pathways by source for BRMS1 Gene

Gene Ontology (GO) - Biological Process for BRMS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
GO:0009987 cellular process IEA --
genes like me logo Genes that share ontologies with BRMS1: view

No data available for SIGNOR curated interactions for BRMS1 Gene

Transcripts for BRMS1 Gene

Unigene Clusters for BRMS1 Gene

Breast cancer metastasis suppressor 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BRMS1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: -
SP2: - -
SP3: -
SP4: -
SP5: -
SP6:

Relevant External Links for BRMS1 Gene

GeneLoc Exon Structure for
BRMS1
ECgene alternative splicing isoforms for
BRMS1

Expression for BRMS1 Gene

mRNA expression in normal human tissues for BRMS1 Gene

Protein differential expression in normal tissues from HIPED for BRMS1 Gene

This gene is overexpressed in Lung (23.9), Pancreas (10.0), CD8 Tcells (8.6), and Blymphocyte (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BRMS1 Gene



Protein tissue co-expression partners for BRMS1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BRMS1 Gene:

BRMS1

SOURCE GeneReport for Unigene cluster for BRMS1 Gene:

Hs.100426

mRNA Expression by UniProt/SwissProt for BRMS1 Gene:

Q9HCU9-BRMS1_HUMAN
Tissue specificity: Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies.
genes like me logo Genes that share expression patterns with BRMS1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for BRMS1 Gene

Orthologs for BRMS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for BRMS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BRMS1 34 35
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia BRMS1 34 35
  • 92.49 (n)
cow
(Bos Taurus)
Mammalia BRMS1 34 35
  • 91.39 (n)
mouse
(Mus musculus)
Mammalia Brms1 34 16 35
  • 89.07 (n)
zebrafish
(Danio rerio)
Actinopterygii brms1 34 35
  • 61.2 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4400 36 35
  • 43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8326 35
  • 24 (a)
OneToMany
Species where no ortholog for BRMS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRMS1 Gene

ENSEMBL:
Gene Tree for BRMS1 (if available)
TreeFam:
Gene Tree for BRMS1 (if available)

Paralogs for BRMS1 Gene

Paralogs for BRMS1 Gene

(2) SIMAP similar genes for BRMS1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with BRMS1: view

Variants for BRMS1 Gene

Sequence variations from dbSNP and Humsavar for BRMS1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs397509396 Pathogenic 66,346,080(-) GAAGG(C/T)CAAGT upstream-variant-2KB, reference, missense
rs397509397 Pathogenic 66,346,129(-) CTGAA(A/G)ATCAG upstream-variant-2KB, reference, missense
rs730882237 Likely pathogenic 66,346,724(-) AACGA(-/TT)GCTGG upstream-variant-2KB, reference, frameshift-variant
rs878853035 Uncertain significance 66,346,230(-) CGAGC(C/T)GCATG upstream-variant-2KB, reference, missense
rs1044139 -- 66,346,046(-) TGAGC(C/T)CTTCC upstream-variant-2KB, utr-variant-3-prime

Variation tolerance for BRMS1 Gene

Residual Variation Intolerance Score: 64.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.55; 77.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BRMS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BRMS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BRMS1 Gene

Disorders for BRMS1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for BRMS1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
malignant melanoma, somatic
  • melanoma
- elite association - COSMIC cancer census association via MalaCards
Search BRMS1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BRMS1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BRMS1
genes like me logo Genes that share disorders with BRMS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BRMS1 Gene

Publications for BRMS1 Gene

  1. Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13. (PMID: 10850410) Seraj M.J. … Welch D.R. (Cancer Res. 2000) 2 3 4 64
  2. Breast cancer metastasis suppressor 1 (BRMS1) is destabilized by the Cul3-SPOP E3 ubiquitin ligase complex. (PMID: 22085717) Kim B. … Kim J.H. (Biochem. Biophys. Res. Commun. 2011) 3 4 64
  3. Sorting nexin 6 interacts with breast cancer metastasis suppressor-1 and promotes transcriptional repression. (PMID: 20830743) Rivera J. … Bravo J. (J. Cell. Biochem. 2010) 3 4 64
  4. Microarray analysis reveals potential mechanisms of BRMS1-mediated metastasis suppression. (PMID: 17896182) Champine P.J. … DeWald D.B. (Clin. Exp. Metastasis 2007) 3 22 64
  5. Breast cancer metastasis suppressor 1 functions as a corepressor by enhancing histone deacetylase 1-mediated deacetylation of RelA/p65 and promoting apoptosis. (PMID: 17000776) Liu Y. … Jones D.R. (Mol. Cell. Biol. 2006) 3 4 64

Products for BRMS1 Gene

Sources for BRMS1 Gene

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