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BRMS1 Gene

protein-coding   GIFtS: 56
GCID: GC11M066104

Breast Cancer Metastasis Suppressor 1

  See BRMS1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Breast Cancer Metastasis Suppressor 11 2
Breast Cancer Metastasis-Suppressor 12

External Ids:    HGNC: 172621   Entrez Gene: 258552   Ensembl: ENSG000001747447   OMIM: 6062595   UniProtKB: Q9HCU93   

Export aliases for BRMS1 gene to outside databases

Previous GC identifers: GC11M068638 GC14P030082 GC14P034285 GC11M065881 GC11M065882 GC11M065861 GC11M062437


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BRMS1 Gene:
This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell
lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a
family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect
leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.
(provided by RefSeq, Jul 2008)

GeneCards Summary for BRMS1 Gene:
BRMS1 (breast cancer metastasis suppressor 1) is a protein-coding gene. Diseases associated with BRMS1 include breast cancer. GO annotations related to this gene include NF-kappaB binding. An important paralog of this gene is SUDS3.

UniProtKB/Swiss-Prot: BRMS1_HUMAN, Q9HCU9
Function: Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the
deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of
anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate
adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of
metastasis suppression in breast carcinoma

Gene Wiki entry for BRMS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BRMS1 gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBRMS1 promoter sequence
   Search Chromatin IP Primers for BRMS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BRMS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13-q13.2   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13-q13.2

BRMS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRMS1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M066104:  view genomic region     (about GC identifiers)

Start:
66,104,804 bp from pter      End:
66,112,596 bp from pter
Size:
7,793 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BRMS1_HUMAN, Q9HCU9 (See protein sequence)
Recommended Name: Breast cancer metastasis-suppressor 1  
Size: 246 amino acids; 28461 Da
Subunit: Homohexamer (Potential). Interacts with SNX6, HDAC1 and RELA. Interacts with ARID4A. Identified in mSin3A
corepressor complexes together with SIN3A, SIN3B, RBBP4, RBBP7, SAP30, SUDS3, ARID4A, HDAC1 and HDAC2. Interacts
with SPOP; this recruits the protein to a ubiquitin ligase complex containing SPOP and CUL3
2 PDB 3D structures from and Proteopedia for BRMS1:
2XUS (3D)        4AUV (3D)    
Secondary accessions: Q6IAI2

Explore the universe of human proteins at neXtProt for BRMS1: NX_Q9HCU9

Explore proteomics data for BRMS1 at MOPED

Post-translational modifications: 

  • Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing SPOP,
    leading to proteasomal degradation1
  • Ubiquitination2 at Lys123
  • Modification sites at PhosphoSitePlus

  • See BRMS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001020128.1  NP_056214.1  

    ENSEMBL proteins: 
     ENSP00000396052   ENSP00000431510   ENSP00000353042   ENSP00000434591   ENSP00000433740  

    BRMS1 Human Recombinant Protein Products:

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    Novus Biologicals BRMS1 Protein
    Novus Biologicals BRMS1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for BRMS1

     
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    Search eBioscience for ELISAs for BRMS1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR013907 Sds3

    Graphical View of Domain Structure for InterPro Entry Q9HCU9

    ProtoNet protein and cluster: Q9HCU9

    1 Blocks protein domain: IPB013907 Sds3-like

    UniProtKB/Swiss-Prot: BRMS1_HUMAN, Q9HCU9
    Domain: Contains an N-terminal anti-parallel coiled coil formed by two BRMS1 chains; this region can form
    homohexamers
    Similarity: Belongs to the BRMS1 family


    Find genes that share domains with BRMS1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BRMS1_HUMAN, Q9HCU9
    Function: Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the
    deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of
    anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate
    adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of
    metastasis suppression in breast carcinoma

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16919237
    GO:0051059NF-kappaB binding IDA17000776
         
    Find genes that share ontologies with BRMS1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for BRMS1:
     Increased S DNA content  Increased number of cells in m 

         1 MGI phenotypic allele for Brms1 (no phenotypes)

    Find genes that share phenotypes with BRMS1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Brms1tm1(KOMP)Vlcg for BRMS1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BRMS1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BRMS1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BRMS1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BRMS1

    miRNA
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    Block miRNA regulation of human, mouse, rat BRMS1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate BRMS1:
    hsa-miR-4251 hsa-miR-149 hsa-miR-145
    SwitchGear 3'UTR luciferase reporter plasmidBRMS1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for BRMS1
    Predesigned siRNA for gene silencing in human, mouse, rat BRMS1

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): BRMS1 (NM_015399)
    Sino Biological Human cDNA Clone for BRMS1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BRMS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRMS1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRMS1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BRMS1_HUMAN, Q9HCU9: Nucleus. Cytoplasm. Note=Predominantly nuclear
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton1
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17000776
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with BRMS1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including BRMS1: 
              Tumor Metastasis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BRMS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BRMS1 (Q9HCU91, 2, 3 ENSP000003960524) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GOLGB1Q147892, 3, ENSP000003418484MINT-64181 I2D: score=4 STRING: ENSP00000341848
    DNAJB6O751901, 3, ENSP000002621774EBI-714781,EBI-1053164 I2D: score=2 STRING: ENSP00000262177
    HDAC4P565241, 3, ENSP000002646064EBI-714781,EBI-308629 I2D: score=2 STRING: ENSP00000264606
    HDAC6Q9UBN71, 3, ENSP000003340614EBI-714781,EBI-301697 I2D: score=2 STRING: ENSP00000334061
    NMIQ132871, 3, ENSP000002433464EBI-714781,EBI-372942 I2D: score=2 STRING: ENSP00000243346
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006915apoptotic process IEA--
    GO:0009987cellular process ----
    GO:0032088negative regulation of NF-kappaB transcription factor activity IDA17000776
    GO:0045892negative regulation of transcription, DNA-templated IDA--

    Find genes that share ontologies with BRMS1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BRMS1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BRMS1 gene (3 alternative transcripts): 
    NM_001024957.1  NM_015399.3  NM_001024958.1  

    Unigene Cluster for BRMS1:

    Breast cancer metastasis suppressor 1
    Hs.100426  [show with all ESTs]
    Unigene Representative Sequence: BM472938
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000425825(uc001oho.1) ENST00000524699 ENST00000359957(uc001ohp.1)
    ENST00000530238(uc009yre.3) ENST00000527375 ENST00000530756 ENST00000534617
    ENST00000525127 ENST00000529544
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat BRMS1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate BRMS1:
    hsa-miR-4251 hsa-miR-149 hsa-miR-145
    SwitchGear 3'UTR luciferase reporter plasmidBRMS1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for BRMS1
    Predesigned siRNA for gene silencing in human, mouse, rat BRMS1
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    GenScript: all cDNA clones in your preferred vector (see all 2): BRMS1 (NM_015399)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BRMS1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRMS1
    Primer
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    OriGene qPCR primer pairs and template standards for BRMS1
    OriGene qSTAR qPCR primer pairs in human, mouse for BRMS1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BRMS1
      QuantiTect SYBR Green Assays in human, mouse, rat BRMS1
      QuantiFast Probe-based Assays in human, mouse, rat BRMS1

    Additional mRNA sequence: 

    AF147350.1 AF159141.1 AK310991.1 AK313773.1 AL050008.1 BC009834.2 CR457173.1 

    13 DOTS entries:

    DT.92434986  DT.203143  DT.100020596  DT.95073095  DT.95073094  DT.120734057  DT.100020597  DT.95073092 
    DT.100793535  DT.95073093  DT.95073096  DT.95154811  DT.100754044 

    Selected AceView cDNA sequences (see all 178):

    CR618839 BU538881 BF531086 BF037901 BQ059745 BI836574 CR617683 BQ681248 
    BG166370 BU146806 CR599820 BM557796 CR617084 CA454165 BE792276 CR620200 
    AA579672 CR620223 CA487347 AW732306 BU838210 BM014765 AW250439 CB131446 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BRMS1 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:        -                                                                                 
    SP2:        -                             -                                                   
    SP3:                                                                          -               
    SP4:        -                                                                                 
    SP5:        -                                                                                 


    ECgene alternative splicing isoforms for BRMS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BRMS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTCAAGAGA
    BRMS1 Expression
    About this image

    BRMS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BRMS1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.100426

    UniProtKB/Swiss-Prot: BRMS1_HUMAN, Q9HCU9
    Tissue specificity: Expression levels are higher in term placentas than in early placentas. Low levels of
    expression observed in normal pregnancies and in molar pregnancies

        Pathway & Disease-focused RT2 Profiler PCR Array including BRMS1: 
              Tumor Metastasis in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat BRMS1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRMS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BRMS1 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Brms11 , 5 breast cancer metastasis-suppressor 11, 5 89.07(n)1
    92.62(a)1
      19 (4.23 cM)5
    1073921  NM_134155.11  NP_598916.11 
     50414045 
    zebrafish
    (Danio rerio)
    Actinopterygii brms11 breast cancer metastasis-suppressor 1 61.2(n)
    59.43(a)
      791681  NM_200097.1  NP_956391.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG44003   -- 43(a)   11D1   --


    ENSEMBL Gene Tree for BRMS1 (if available)
    TreeFam Gene Tree for BRMS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BRMS1 gene
    SUDS32  BRMS1L2  
    2 SIMAP similar genes for BRMS1 using alignment to 5 protein entries:     BRMS1_HUMAN (see all proteins):
    DKFZp564A063    BRMS1L

    Find genes that share paralogs with BRMS1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BRMS1 (see all 197)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1399582711,2
    C--66106090(+) GGAAGC/GCTTGG 2 -- int10--------
    rs2021044391,2
    --66106171(+) GTCACG/TTGGGC 2 -- int10--------
    rs2010480771,2
    --66106186(+) GCGGCA/CCCCAC 2 -- int10--------
    rs2011582261,2
    C--66106246(+) TACACA/C/GATGTA 6 I M mis1 syn10--------
    rs1434899521,2
    C,F--66106261(+) CCTGTG/AGTGGG 2 -- int11Minor allele frequency- A:0.05EU 1323
    rs2002738401,2
    --66106294(+) TGGCAC/GGTGAC 2 -- int10--------
    rs1852829251,2
    --66106426(+) GGGGTC/TGTCCT 2 -- int10--------
    rs1454388031,2
    --66106432(+) GTCCTA/GGAACC 2 -- int10--------
    rs1488343201,2
    C--66106529(+) CTCACA/TCTGCA 2 -- int10--------
    rs1425602181,2
    C--66106538(+) CAGCAC/TTGGCC 2 -- int10--------

    HapMap Linkage Disequilibrium report for BRMS1 (66104804 - 66112596 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for BRMS1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv897783CNV Loss21882294
    nsv897772CNV Loss21882294
    dgv1187n71CNV Loss21882294
    dgv1190n71CNV Loss21882294
    dgv1189n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BRMS1
    DNA2.0 Custom Variant and Variant Library Synthesis for BRMS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606259    OMIM disorders: --

    1 disease for BRMS1:    
    About MalaCards
    breast cancer

    1 disease from the University of Copenhagen DISEASES database for BRMS1:
    Breast cancer

    Find genes that share disorders with BRMS1           About GenesLikeMe

    8 Novoseek inferred disease relationships for BRMS1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast carcinoma 60.6 8 11827072 (4), 11822878 (1), 11774238 (1), 11280719 (1) (see all 5)
    primary tumor 51.7 2 15592684 (1), 16681721 (1)
    breast cancer metastatic 50.4 1 15252837 (1)
    metastasis 49.2 28 11822878 (5), 16681721 (5), 11827072 (4), 15592684 (2) (see all 9)
    breast cancer 45.7 13 15592684 (3), 16681721 (3), 15252837 (2), 11822878 (1) (see all 6)
    melanoma 34.7 10 11822878 (4), 16681721 (3)
    tumors 11.2 14 11822878 (3), 16681721 (3), 11827072 (1), 17896182 (1)
    carcinoma 10.7 2 15252837 (1)


    Export disorders for BRMS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BRMS1 gene, integrated from 10 sources (see all 70):
    (articles sorted by number of sources associating them with BRMS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13. (PubMed id 10850410)1, 2, 3 Seraj M.J.... Welch D.R. (Cancer Res. 2000)
    2. Breast cancer metastasis suppressor 1 (BRMS1) is destabilized by the Cul3-SPOP E3 ubiquitin ligase complex. (PubMed id 22085717)1, 2 Kim B.... Kim J.H. (Biochem. Biophys. Res. Commun. 2011)
    3. Sorting nexin 6 interacts with breast cancer metastasis suppressor-1 and promotes transcriptional repression. (PubMed id 20830743)1, 2 Rivera J.... Bravo J. (J. Cell. Biochem. 2010)
    4. Breast cancer metastasis suppressor 1 functions as a corepressor by enhancing histone deacetylase 1-mediated deacetylation of RelA/p65 and promoting apoptosis. (PubMed id 17000776)1, 2 Liu Y.... Jones D.R. (Mol. Cell. Biol. 2006)
    5. Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription. (PubMed id 14581478)1, 2 Meehan W.J.... Welch D.R. (J. Biol. Chem. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells. (PubMed id 12414911)1, 2 Janneau J.-L.... Bellet D. (J. Clin. Endocrinol. Metab. 2002)
    8. Suppression of human melanoma metastasis by the metastasis suppressor gene, BRMS1. (PubMed id 11822878)1, 9 Shevde L.A....Welch D.R. (Exp. Cell Res. 2002)
    9. Identification and characterization of the murine ortholog (brms1) of breast-cancer metastasis suppressor 1 (BRMS1). (PubMed id 11774238)1, 9 Samant R.S....Welch D.R. (Int. J. Cancer 2002)
    10. Microarray analysis reveals potential mechanisms of BRMS1-mediated metastasis suppression. (PubMed id 17896182)1, 9 Champine P.J....DeWald D.B. (amp 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
    Disorders
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      Query String
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    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25855 HGNC: 17262 AceView: BRMS1 Ensembl:ENSG00000174744 euGenes: HUgn25855
    ECgene: BRMS1 H-InvDB: BRMS1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BRMS1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BRMS1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BRMS1 gene:
    Search GeneIP for patents involving BRMS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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