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Aliases for BRK1 Gene

Aliases for BRK1 Gene

  • BRICK1, SCAR/WAVE Actin Nucleating Complex Subunit 2 3
  • BRICK1, SCAR/WAVE Actin-Nucleating Complex Subunit 2 3 5
  • Haematopoietic Stem/Progenitor Cell Protein 300 2 3
  • C3orf10 3 4
  • BRICK1, SCAR/WAVE Actin-Nucleating Complex Subunit, Homolog 3
  • SCAR/WAVE Actin-Nucleating Complex Subunit 2
  • Chromosome 3 Open Reading Frame 10 2
  • Homolog (Arabidopsis Thaliana) 2
  • Probable Protein BRICK1 3
  • HSPC300 3
  • BRICK1 2
  • MDS027 3
  • HHBrk1 3

External Ids for BRK1 Gene

Previous HGNC Symbols for BRK1 Gene

  • C3orf10

Previous GeneCards Identifiers for BRK1 Gene

  • GC03P010162
  • GC03P010163
  • GC03P010164
  • GC03P010165
  • GC03P010166
  • GC03P010167

Summaries for BRK1 Gene

GeneCards Summary for BRK1 Gene

BRK1 (BRICK1, SCAR/WAVE Actin Nucleating Complex Subunit) is a Protein Coding gene. Among its related pathways are Regulation of actin dynamics for phagocytic cup formation and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include protein complex binding and Rac GTPase binding.

UniProtKB/Swiss-Prot for BRK1 Gene

  • Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.

Gene Wiki entry for BRK1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRK1 Gene

Genomics for BRK1 Gene

Regulatory Elements for BRK1 Gene

Enhancers for BRK1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BRK1 on UCSC Golden Path with GeneCards custom track

Promoters for BRK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BRK1 on UCSC Golden Path with GeneCards custom track

Genomic Location for BRK1 Gene

Chromosome:
3
Start:
10,115,592 bp from pter
End:
10,127,190 bp from pter
Size:
11,599 bases
Orientation:
Plus strand

Genomic View for BRK1 Gene

Genes around BRK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRK1 Gene

Proteins for BRK1 Gene

  • Protein details for BRK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUW1-BRK1_HUMAN
    Recommended name:
    Protein BRICK1
    Protein Accession:
    Q8WUW1
    Secondary Accessions:
    • B2R5E2
    • Q9P082

    Protein attributes for BRK1 Gene

    Size:
    75 amino acids
    Molecular mass:
    8745 Da
    Quaternary structure:
    • Homotrimer when in free form. Directly interacts with WASF2. Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterdimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1.
    SequenceCaution:
    • Sequence=AAF28978.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BRK1 Gene

    Alternative splice isoforms for BRK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BRK1 Gene

Proteomics data for BRK1 Gene at MOPED

Post-translational modifications for BRK1 Gene

  • Ubiquitination at Lys 31, Lys 53, and Lys 70
  • Modification sites at PhosphoSitePlus

Other Protein References for BRK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BRK1 Gene

Domains & Families for BRK1 Gene

Protein Domains for BRK1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for BRK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUW1

UniProtKB/Swiss-Prot:

BRK1_HUMAN :
  • Belongs to the BRK1 family.
Family:
  • Belongs to the BRK1 family.
genes like me logo Genes that share domains with BRK1: view

No data available for Gene Families for BRK1 Gene

Function for BRK1 Gene

Molecular function for BRK1 Gene

UniProtKB/Swiss-Prot Function:
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.

Gene Ontology (GO) - Molecular Function for BRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048365 contributes_to Rac GTPase binding IDA 21107423
genes like me logo Genes that share ontologies with BRK1: view
genes like me logo Genes that share phenotypes with BRK1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BRK1 Gene

Localization for BRK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRK1 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BRK1 Gene COMPARTMENTS Subcellular localization image for BRK1 gene
Compartment Confidence
extracellular 5
cytoskeleton 4
cytosol 4

Gene Ontology (GO) - Cellular Components for BRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with BRK1: view

Pathways & Interactions for BRK1 Gene

genes like me logo Genes that share pathways with BRK1: view

Pathways by source for BRK1 Gene

Gene Ontology (GO) - Biological Process for BRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0016601 Rac protein signal transduction IDA 21107423
GO:0045087 innate immune response TAS --
GO:0048010 vascular endothelial growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with BRK1: view

No data available for SIGNOR curated interactions for BRK1 Gene

Drugs & Compounds for BRK1 Gene

No Compound Related Data Available

Transcripts for BRK1 Gene

mRNA/cDNA for BRK1 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(582) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BRK1 Gene

BRICK1, SCAR/WAVE actin-nucleating complex subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BRK1 Gene

No ASD Table

Relevant External Links for BRK1 Gene

GeneLoc Exon Structure for
BRK1
ECgene alternative splicing isoforms for
BRK1

Expression for BRK1 Gene

mRNA expression in normal human tissues for BRK1 Gene

Protein differential expression in normal tissues from HIPED for BRK1 Gene

This gene is overexpressed in Breast (10.9), Bone (7.7), Fetal Brain (7.5), and Peripheral blood mononuclear cells (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BRK1 Gene



SOURCE GeneReport for Unigene cluster for BRK1 Gene Hs.649307

genes like me logo Genes that share expression patterns with BRK1: view

Protein tissue co-expression partners for BRK1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BRK1 Gene

Orthologs for BRK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for BRK1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BRK1 35
  • 93.33 (n)
  • 98.67 (a)
C22H3ORF10 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC607701 35
  • 94.22 (n)
  • 98.67 (a)
BRK1 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Brk1 35
  • 94.67 (n)
  • 98.67 (a)
Brk1 16
Brk1 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BRK1 35
  • 100 (n)
  • 100 (a)
BRK1 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Brk1 35
  • 93.78 (n)
  • 98.67 (a)
oppossum
(Monodelphis domestica)
Mammalia BRK1 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia brk1 35
  • 82.67 (n)
  • 97.33 (a)
Str.6199 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.10906 35
zebrafish
(Danio rerio)
Actinopterygii Dr.13925 35
zgc:86903 35
  • 74.67 (n)
  • 98.67 (a)
BRK1 36
  • 80 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8986 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007614 35
  • 67.57 (n)
  • 75.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta HSPC300 35
  • 68 (n)
  • 74.67 (a)
HSPC300 36
  • 71 (a)
OneToOne
Species with no ortholog for BRK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRK1 Gene

ENSEMBL:
Gene Tree for BRK1 (if available)
TreeFam:
Gene Tree for BRK1 (if available)

Paralogs for BRK1 Gene

Pseudogenes.org Pseudogenes for BRK1 Gene

genes like me logo Genes that share paralogs with BRK1: view

No data available for Paralogs for BRK1 Gene

Variants for BRK1 Gene

Sequence variations from dbSNP and Humsavar for BRK1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs364714 -- 10,122,574(+) caggc(A/C)cagtg intron-variant
rs265319 -- 10,117,642(+) tccac(C/T)cgctt intron-variant
rs811907 -- 10,119,207(-) agtgc(C/T)gggat intron-variant
rs571397 -- 10,124,639(-) agcag(G/T)gactc intron-variant
rs696328 -- 10,120,037(-) aaaaa(A/C)aaaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BRK1 Gene

Variant ID Type Subtype PubMed ID
dgv809e201 CNV Deletion 23290073
nsv436362 CNV Deletion 17901297
nsv436869 CNV Insertion 17901297
esv4117 CNV Complex 18987735

Variation tolerance for BRK1 Gene

Residual Variation Intolerance Score: 53.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.06% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for BRK1 Gene

Disorders for BRK1 Gene

Relevant External Links for BRK1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BRK1

No disorders were found for BRK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BRK1 Gene

Publications for BRK1 Gene

  1. Structure and control of the actin regulatory WAVE complex. (PMID: 21107423) Chen Z. … Rosen M.K. (Nature 2010) 3 4 67
  2. Solid renal tumor severity in von Hippel Lindau disease is related to germline deletion length and location. (PMID: 14695531) Maranchie J.K. … Linehan W.M. (Hum. Mutat. 2004) 2 3
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for BRK1 Gene

Sources for BRK1 Gene

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