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Aliases for BRK1 Gene

Aliases for BRK1 Gene

  • BRICK1, SCAR/WAVE Actin-Nucleating Complex Subunit 2 3
  • C3orf10 3 4 6
  • Haematopoietic Stem/Progenitor Cell Protein 300 2 3
  • HSPC300 3 6
  • BRICK1, SCAR/WAVE Actin-Nucleating Complex Subunit, Homolog 3
  • SCAR/WAVE Actin-Nucleating Complex Subunit 2
  • Chromosome 3 Open Reading Frame 10 2
  • Homolog (Arabidopsis Thaliana) 2
  • Probable Protein BRICK1 3
  • Protein BRICK1 3
  • BRICK1 2
  • MDS027 3
  • HHBrk1 3

External Ids for BRK1 Gene

Previous HGNC Symbols for BRK1 Gene

  • C3orf10

Previous GeneCards Identifiers for BRK1 Gene

  • GC03P010162
  • GC03P010163
  • GC03P010164
  • GC03P010165
  • GC03P010166
  • GC03P010167

Summaries for BRK1 Gene

GeneCards Summary for BRK1 Gene

BRK1 (BRICK1, SCAR/WAVE Actin-Nucleating Complex Subunit) is a Protein Coding gene. Among its related pathways are Regulation of actin cytoskeleton and Regulation of actin cytoskeleton.

UniProtKB/Swiss-Prot for BRK1 Gene

  • Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.

Gene Wiki entry for BRK1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRK1 Gene

Genomics for BRK1 Gene

Genomic Location for BRK1 Gene

10,115,592 bp from pter
10,127,190 bp from pter
11,599 bases
Plus strand

Genomic View for BRK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BRK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRK1 Gene

No data available for Regulatory Elements for BRK1 Gene

Proteins for BRK1 Gene

  • Protein details for BRK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein BRICK1
    Protein Accession:
    Secondary Accessions:
    • B2R5E2
    • Q9P082

    Protein attributes for BRK1 Gene

    75 amino acids
    Molecular mass:
    8745 Da
    Quaternary structure:
    • Homotrimer when in free form. Directly interacts with WASF2. Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterdimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1.
    • Sequence=AAF28978.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BRK1 Gene

    Alternative splice isoforms for BRK1 Gene


neXtProt entry for BRK1 Gene

Proteomics data for BRK1 Gene at MOPED

Post-translational modifications for BRK1 Gene

  • Ubiquitination at Lys31, Lys53, and Lys70
  • Modification sites at PhosphoSitePlus

Other Protein References for BRK1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for BRK1 Gene

Domains for BRK1 Gene

Protein Domains for BRK1 Gene


Suggested Antigen Peptide Sequences for BRK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8WUW1
  • Belongs to the BRK1 family.
genes like me logo Genes that share domains with BRK1: view

No data available for Gene Families for BRK1 Gene

Function for BRK1 Gene

Molecular function for BRK1 Gene

UniProtKB/Swiss-Prot Function: Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex.

Gene Ontology (GO) - Molecular Function for BRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0032403 protein complex binding IDA 18560548
GO:0048365 contributes_to Rac GTPase binding IDA 21107423
genes like me logo Genes that share ontologies with BRK1: view
genes like me logo Genes that share phenotypes with BRK1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BRK1 Gene

Localization for BRK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRK1 Gene

Cytoplasm, cytoskeleton.

Gene Ontology (GO) - Cellular Components for BRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0030027 lamellipodium ISS --
GO:0031209 SCAR complex IDA 21107423
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with BRK1: view

No data available for Subcellular locations from COMPARTMENTS for BRK1 Gene

Pathways for BRK1 Gene

genes like me logo Genes that share pathways with BRK1: view

Pathways by source for BRK1 Gene

1 KEGG pathway for BRK1 Gene
1 GeneGo (Thomson Reuters) pathway for BRK1 Gene

Gene Ontology (GO) - Biological Process for BRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0010592 positive regulation of lamellipodium assembly IMP 18560548
GO:0016601 Rac protein signal transduction IDA 21107423
genes like me logo Genes that share ontologies with BRK1: view

Transcripts for BRK1 Gene

mRNA/cDNA for BRK1 Gene

(582) Selected AceView cDNA sequences:
(9) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BRK1 Gene

BRICK1, SCAR/WAVE actin-nucleating complex subunit:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BRK1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BRK1 Gene

No ASD Table

Relevant External Links for BRK1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BRK1 Gene

mRNA expression in normal human tissues for BRK1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BRK1 Gene

SOURCE GeneReport for Unigene cluster for BRK1 Gene Hs.649307

genes like me logo Genes that share expressions with BRK1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BRK1 Gene

Orthologs for BRK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for BRK1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BRK1 35
  • 100 (n)
  • 100 (a)
BRK1 36
  • 70 (a)
(Bos Taurus)
Mammalia BRK1 35
  • 93.33 (n)
  • 98.67 (a)
C22H3ORF10 36
  • 99 (a)
(Canis familiaris)
Mammalia BRK1 36
  • 70 (a)
LOC607701 35
  • 94.22 (n)
  • 98.67 (a)
(Mus musculus)
Mammalia Brk1 35
  • 94.67 (n)
  • 98.67 (a)
Brk1 16
Brk1 36
  • 99 (a)
(Monodelphis domestica)
Mammalia BRK1 36
  • 69 (a)
(Rattus norvegicus)
Mammalia Brk1 35
  • 93.78 (n)
  • 98.67 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10906 35
tropical clawed frog
(Silurana tropicalis)
Amphibia brk1 35
  • 82.67 (n)
  • 97.33 (a)
Str.6199 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8986 35
(Danio rerio)
Actinopterygii BRK1 36
  • 80 (a)
Dr.13925 35
zgc:86903 35
  • 74.67 (n)
  • 98.67 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007614 35
  • 67.57 (n)
  • 75.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta HSPC300 35
  • 68 (n)
  • 74.67 (a)
HSPC300 36
  • 71 (a)
Species with no ortholog for BRK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRK1 Gene

Gene Tree for BRK1 (if available)
Gene Tree for BRK1 (if available)

Paralogs for BRK1 Gene Pseudogenes for BRK1 Gene

genes like me logo Genes that share paralogs with BRK1: view

No data available for Paralogs for BRK1 Gene

Variants for BRK1 Gene

Sequence variations from dbSNP and Humsavar for BRK1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs265319 -- 10,117,642(+) tccac(C/T)cgctt intron-variant
rs364714 -- 10,122,574(+) caggc(A/C)cagtg intron-variant
rs571397 -- 10,124,639(-) agcag(G/T)gactc intron-variant
rs696328 -- 10,120,037(-) aaaaa(A/C)aaaaa intron-variant
rs697815 -- 10,123,570(-) gtaat(C/T)ccagc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BRK1 Gene

Variant ID Type Subtype PubMed ID
dgv809e201 CNV Deletion 23290073
nsv436362 CNV Deletion 17901297
nsv436869 CNV Insertion 17901297
esv4117 CNV Complex 18987735

Relevant External Links for BRK1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRK1 Gene

Disorders for BRK1 Gene

No disorders were found for BRK1 Gene.

No data available for UniProtKB/Swiss-Prot for BRK1 Gene

Publications for BRK1 Gene

  1. Solid renal tumor severity in von Hippel Lindau disease is related to germline deletion length and location. (PMID: 14695531) Maranchie J.K. … Linehan W.M. (Hum. Mutat. 2004) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Structure and control of the actin regulatory WAVE complex. (PMID: 21107423) Chen Z. … Rosen M.K. (Nature 2010) 3 4
  4. Free Brick1 is a trimeric precursor in the assembly of a functional wave complex. (PMID: 18560548) Derivery E. … Gautreau A. (PLoS ONE 2008) 3 4
  5. Metastatic potential of lung squamous cell carcinoma associated with HSPC300 through its interaction with WAVE2. (PMID: 19576655) Cai X. … Zhang K. (Lung Cancer 2009) 3

Products for BRK1 Gene

Sources for BRK1 Gene

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