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BRK1 Gene

protein-coding   GIFtS: 45
GCID: GC03P010167

BRICK1, SCAR/WAVE Actin-Nucleating Complex Subunit

(Previous name: chromosome 3 open reading frame 10)
(Previous symbol: C3orf10)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
BRICK1, SCAR/WAVE Actin-Nucleating Complex Subunit1 2     MDS0272
C3orf101 2 3 5     BRICK1, SCAR/WAVE Actin-Nucleating Complex Subunit, Homolog2
Haematopoietic Stem/Progenitor Cell Protein 3001 2     hHBrk12
BRICK11     Probable Protein BRICK12
Chromosome 3 Open Reading Frame 101     Protein BRICK12
Homolog (Arabidopsis Thaliana)1     HSPC3005
SCAR/WAVE Actin-Nucleating Complex Subunit1     

External Ids:    HGNC: 230571   Entrez Gene: 558452   Ensembl: ENSG000002549997   OMIM: 6111835   UniProtKB: Q8WUW13   

Export aliases for BRK1 gene to outside databases

Previous GC identifers: GC03P010162 GC03P010163 GC03P010164 GC03P010165 GC03P010166


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for BRK1 Gene:
BRK1 (BRICK1, SCAR/WAVE actin-nucleating complex subunit) is a protein-coding gene.

UniProtKB/Swiss-Prot: BRK1_HUMAN, Q8WUW1
Function: Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the
Arp2/3 complex

Gene Wiki entry for BRK1 (C3orf10) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Search for regulatory transcription factor binding sites for BRK1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBRK1 promoter sequence
   Search Chromatin IP Primers for BRK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BRK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.3   Ensembl cytogenetic band:  3p25.3   HGNC cytogenetic band: 3p25.3

BRK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRK1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P010167:  view genomic region     (about GC identifiers)

Start:
10,157,276 bp from pter      End:
10,168,874 bp from pter
Size:
11,599 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BRK1_HUMAN, Q8WUW1 (See protein sequence)
Recommended Name: Protein BRICK1  
Size: 75 amino acids; 8745 Da
Subunit: Homotrimer when in free form. Directly interacts with WASF2. Component of the WAVE1 complex composed of
ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterdimer containing NCKAP1 and
CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1
Sequence caution: Sequence=AAF28978.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for BRK1:
3P8C (3D)    
Secondary accessions: B2R5E2 Q9P082
Alternative splicing: 2 isoforms:  Q8WUW1-1   Q8WUW1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BRK1: NX_Q8WUW1

Explore proteomics data for BRK1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys31, Lys53, Lys70
  • Modification sites at PhosphoSitePlus

  • See BRK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060932.2  
    ENSEMBL proteins: 
     ENSP00000432472   ENSP00000444659  
    Reactome Protein details: Q8WUW1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q8WUW1

    UniProtKB/Swiss-Prot: BRK1_HUMAN, Q8WUW1
    Similarity: Belongs to the BRK1 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BRK1_HUMAN, Q8WUW1
    Function: Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the
    Arp2/3 complex

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032403protein complex binding IDA18560548
    GO:0048365contributes to Rac GTPase binding IDA--
         
    Find genes that share ontologies with BRK1           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Brk1):
     cellular  embryogenesis  growth/size/body  mortality/aging  reproductive system 

    Find genes that share phenotypes with BRK1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BRK1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BRK1
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate BRK1 (see all 12):
    hsa-miR-498 hsa-miR-146b-3p hsa-miR-186* hsa-miR-15a hsa-miR-497 hsa-miR-3647-3p hsa-miR-1251 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidBRK1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat BRK1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BRK1_HUMAN, Q8WUW1: Cytoplasm, cytoskeleton (By similarity)

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton IEA--
    GO:0030027lamellipodium ISS--
    GO:0031209SCAR complex IDA--
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with BRK1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BRK1 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    2Fcgamma receptor (FCGR) dependent phagocytosis
    Regulation of actin dynamics for phagocytic cup formation0.77
    Fcgamma receptor (FCGR) dependent phagocytosis0.77
    3G protein signaling RAC1 in cellular process
    G protein signaling RAC1 in cellular process0.37
    4CDC42 signaling events
    RAC1 signaling pathway0.34
    5ErbB1 downstream signaling
    ErbB1 downstream signaling


    Find genes that share SuperPaths with BRK1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for BRK1
        Rac1 Pathway

    1 GeneGo (Thomson Reuters) Pathway for BRK1
        G-protein signaling RAC1 in cellular process

    3 BioSystems Pathways for BRK1
        Regulation of Actin Cytoskeleton
    ErbB1 downstream signaling
    RAC1 signaling pathway


    1 Reactome Pathway for BRK1
        Regulation of actin dynamics for phagocytic cup formation


    1 Kegg Pathway  (Kegg details for BRK1):
        Regulation of actin cytoskeleton

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BRK1
    Interactions:

        Search GeneGlobe Interaction Network for BRK1

    Selected Interacting proteins for BRK1 (Q8WUW12, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PFDN1O609252, 3MINT-8265720 I2D: score=2 
    WASF1Q925582, 3MINT-17058 I2D: score=2 
    ABI1Q8IZP03I2D: score=1 
    CYFIP2Q96F073I2D: score=1 
    NCK1P163333I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0010592positive regulation of lamellipodium assembly IMP18560548
    GO:0016601Rac protein signal transduction IDA--
    GO:0030036actin cytoskeleton organization IEA--

    Find genes that share ontologies with BRK1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BRK1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BRK1 gene: 
    NM_018462.4  

    Unigene Cluster for BRK1:

    BRICK1, SCAR/WAVE actin-nucleating complex subunit
    Hs.649307  [show with all ESTs]
    Unigene Representative Sequence: BF102725
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000530758(uc003bvb.3) ENST00000256463
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate BRK1 (see all 12):
    hsa-miR-498 hsa-miR-146b-3p hsa-miR-186* hsa-miR-15a hsa-miR-497 hsa-miR-3647-3p hsa-miR-1251 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidBRK1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat BRK1
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    Primer
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    OriGene qPCR primer pairs and template standards for BRK1
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      QuantiTect SYBR Green Assays in human, mouse, rat BRK1
      QuantiFast Probe-based Assays in human, mouse, rat BRK1

    Additional mRNA sequence: 

    AF161418.1 AK290580.1 AK312155.1 AY148219.1 AY148220.1 BC001067.1 BC007929.1 BC019303.1 
    BC061515.1 

    24 DOTS entries:

    DT.454565  DT.100880746  DT.92047200  DT.97760294  DT.91979578  DT.95231276  DT.91908712  DT.91786041 
    DT.100880742  DT.120922768  DT.91763462  DT.91846616  DT.92439090  DT.120922748  DT.91855549  DT.100880745 
    DT.100880748  DT.120922764  DT.100707706  DT.101982322  DT.120922758  DT.85104605  DT.92380635  DT.95231265 

    Selected AceView cDNA sequences (see all 582):

    BU681150 AV650598 CD369624 CN481790 BE208438 BU741409 BM452015 AA375963 
    BG755140 BM843336 BQ084571 CR607817 AI634611 BF061116 BM980964 BQ420540 
    CR621273 BM472232 AI097081 BM472265 AA301129 AI763302 BG576549 BF726150 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BRK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTGGCAAT
    BRK1 Expression
    About this image

    BRK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BRK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.649307
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BRK1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Brk11 , 5 RIKEN cDNA 6720456B07 gene5
    BRICK1, SCAR/WAVE actin-nucleating complex subunit1
    94.67(n)1
    98.67(a)1
      6 (52.81 cM)5
    1013141  NM_133937.11  NP_598698.11 
     1136047725 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.109062 Xenopus laevis transcribed sequences 83.4(n)    BJ080684.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.139252 Danio rerio, Similar to uncharacterized hematopoietic more 74.81(n)    BC046048.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta HSPC3001 HSPC300 68(n)
    74.67(a)
      246497  NM_166648.2  NP_726400.1 


    ENSEMBL Gene Tree for BRK1 (if available)
    TreeFam Gene Tree for BRK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BRK1 gene

    Find genes that share paralogs with BRK1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for BRK1
    PGOHUM00000257957 PGOHUM00000260940


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BRK1 (see all 322)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1123482221,2
    C,F--10155487(+) CTCACG/ACCTGT 1 -- us2k13Minor allele frequency- A:0.20NA WA CSA 5
    rs609906461,2
    C--10155584(+) TCTCTA/GGTAAA 1 -- us2k12Minor allele frequency- G:0.33NA CSA 3
    rs361261141,2
    C--10155587(+) AAAAA-/ATTAGC 1 -- us2k10--------
    rs586986441,2
    C,F--10155611(+) CTGTGA/TGTGGT 1 -- us2k12Minor allele frequency- T:0.33NA CSA 3
    rs1493789851,2
    --10155823(+) ACTACA/CTTAGC 1 -- us2k10--------
    rs1924718431,2
    --10155827(+) CCTTAA/GCAAAG 1 -- us2k10--------
    rs170324031,2
    C,F,H--10155882(+) CATTTT/CTCCAT 1 -- us2k116Minor allele frequency- C:0.03NA NS EA WA 1222
    rs1858030611,2
    --10155918(+) CCAGGA/CAGGGT 1 -- us2k10--------
    rs1875882701,2
    C--10155979(+) CTTGAA/GGTCAG 1 -- us2k10--------
    rs1167746331,2
    F--10156176(+) GCATTA/CACAGA 1 -- us2k11Minor allele frequency- C:0.08NA 120

    HapMap Linkage Disequilibrium report for BRK1 (10157276 - 10168874 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for BRK1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv809e201CNV Deletion23290073
    nsv436362CNV Deletion17901297
    nsv436869CNV Insertion17901297
    esv4117CNV Complex18987735

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing BRK1
    DNA2.0 Custom Variant and Variant Library Synthesis for BRK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611183    OMIM disorders: --


    Find genes that share disorders with BRK1           About GenesLikeMe


    Export disorders for BRK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BRK1 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with BRK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Free Brick1 is a trimeric precursor in the assembly of a functional wave complex. (PubMed id 18560548)1, 2 Derivery E.... Gautreau A. (PLoS ONE 2008)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Solid renal tumor severity in von Hippel Lindau disease is related to germline deletion length and location. (PubMed id 14695531)1, 3 Maranchie J.K....Linehan W.M. (Hum. Mutat. 2004)
    4. Novel genes FAM134C, C3orf10 and ENOX1 are regulated by NRF-1 and differentially regulate neurite outgrowth in neuroblastoma cells and hippocampal neurons. (PubMed id 23939472)1 Wang J.L....Huang A.M. (Gene 2013)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    9. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55845 HGNC: 23057 AceView: C3orf10 Ensembl:ENSG00000254999 euGenes: HUgn55845
    ECgene: BRK1 Kegg: 55845 H-InvDB: BRK1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BRK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BRK1 gene:
    Search GeneIP for patents involving BRK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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