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BRIX1 Gene

protein-coding   GIFtS: 50
GCID: GC05P034916

BRX1, Biogenesis Of Ribosomes, Homolog (S. Cerevisiae)

(Previous name: brix domain containing 2)
(Previous symbol: BXDC2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
BRX1, Biogenesis Of Ribosomes, Homolog (S. Cerevisiae)1 2
BXDC21 2 3
Brix Domain Containing 21 2
Brix Domain-Containing Protein 22 3
BRIX2 3
Ribosome Biogenesis Protein BRX1 Homolog2

External Ids:    HGNC: 241701   Entrez Gene: 552992   Ensembl: ENSG000001134607   UniProtKB: Q8TDN63   

Export aliases for BRIX1 gene to outside databases

Previous GC identifer: GC05P034953


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for BRIX1 Gene:
BRIX1 (BRX1, biogenesis of ribosomes, homolog (S. cerevisiae)) is a protein-coding gene.

UniProtKB/Swiss-Prot: BRX1_HUMAN, Q8TDN6
Function: Required for biogenesis of the 60S ribosomal subunit

Gene Wiki entry for BRIX1 (BXDC2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for BRIX1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBRIX1 promoter sequence
   Search Chromatin IP Primers for BRIX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BRIX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13.2   Ensembl cytogenetic band:  5p13.2   HGNC cytogenetic band: 5p13.2

BRIX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRIX1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P034916:  view genomic region     (about GC identifiers)

Start:
34,915,481 bp from pter      End:
34,926,101 bp from pter
Size:
10,621 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: BRX1_HUMAN, Q8TDN6 (See protein sequence)
Recommended Name: Ribosome biogenesis protein BRX1 homolog  
Size: 353 amino acids; 41401 Da
Secondary accessions: A8K0P5 Q3ZTT4 Q8N453 Q96DH1

Explore the universe of human proteins at neXtProt for BRIX1: NX_Q8TDN6

Explore proteomics data for BRIX1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys276
  • Modification sites at PhosphoSitePlus

  • See BRIX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060791.3  
    ENSEMBL proteins: 
     ENSP00000338862  

    BRIX1 Human Recombinant Protein Products:

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    Novus Biologicals BRIX1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for BRIX1 

     
    antibodies-online proteins for BRIX1 (6 products) 

     
    antibodies-online peptides for BRIX1

    BRIX1 Antibody Products:

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    Abcam antibodies for BRIX1
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    antibodies-online antibodies for BRIX1 (38 products) 

    BRIX1 Assay Products:

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    GenScript Custom Assay Services for BRIX1
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    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for BRIX1 
    antibodies-online kits for BRIX1 (5 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR007109 Brix
     IPR004154 Anticodon-bd
     IPR026532 BRX1

    Graphical View of Domain Structure for InterPro Entry Q8TDN6

    ProtoNet protein and cluster: Q8TDN6

    1 Blocks protein domain: IPB007109 Brix domain

    UniProtKB/Swiss-Prot: BRX1_HUMAN, Q8TDN6
    Similarity: Belongs to the BRX1 family
    Similarity: Contains 1 Brix domain


    Find genes that share domains with BRIX1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BRX1_HUMAN, Q8TDN6
    Function: Required for biogenesis of the 60S ribosomal subunit

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with BRIX1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for BRIX1:
     Low eccentricity cells  Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for BRIX1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat BRIX1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate BRIX1:
    hsa-miR-466
    SwitchGear 3'UTR luciferase reporter plasmidBRIX1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BRIX1
    Predesigned siRNA for gene silencing in human, mouse, rat BRIX1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BRIX1

    Clone
    Products:
         
    OriGene clones in human, mouse for BRIX1 (see all 8)
    OriGene ORF clones in mouse, rat for BRIX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BRIX1 (NM_018321)
    Sino Biological Human cDNA Clone for BRIX1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BRIX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRIX1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for BRIX1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRIX1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BRX1_HUMAN, Q8TDN6: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--

    Find genes that share ontologies with BRIX1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BRIX1 About    
    See pathways by source

    SuperPathContained pathways About
    1Gastric cancer network 2
    Gastric cancer network 2


    1 BioSystems Pathway for BRIX1
        Gastric cancer network 2



        Pathway & Disease-focused RT2 Profiler PCR Array including BRIX1: 
              Embryonic Stem Cells in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for BRIX1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BRIX1 (Q8TDN62, 3 ENSP000003388624) via UniProtKB, MINT, STRING, and/or I2D (see all 937)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042254ribosome biogenesis IEA--

    Find genes that share ontologies with BRIX1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BRIX1 (BRX1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BRIX1 gene: 
    NM_018321.3  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336767(uc003jja.3) ENST00000510960(uc011col.1) ENST00000515798
    ENST00000510834(uc003jiz.3) ENST00000506023
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat BRIX1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate BRIX1:
    hsa-miR-466
    SwitchGear 3'UTR luciferase reporter plasmidBRIX1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for BRIX1
    Predesigned siRNA for gene silencing in human, mouse, rat BRIX1
    Clone
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    OriGene clones in human, mouse for BRIX1 (see all 8)
    OriGene ORF clones in mouse, rat for BRIX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BRIX1 (NM_018321)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BRIX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRIX1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for BRIX1
    OriGene qSTAR qPCR primer pairs in human, mouse for BRIX1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BRIX1
      QuantiTect SYBR Green Assays in human, mouse, rat BRIX1
      QuantiFast Probe-based Assays in human, mouse, rat BRIX1

    Selected AceView cDNA sequences (see all 150):

    CD367156 BU167897 AA418770 AW469857 AA857813 AW271982 AW001647 AA730033 
    BM553394 BE464605 BM978019 BG289827 BM980934 CR593646 BI963051 AA454607 
    BM764158 BC001546 CR622822 AW469852 AA418699 AA576507 BF593188 BX952902 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BRIX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCCCACTGC
    BRIX1 Expression
    About this image


    BRIX1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Inner Cell Mass (Early Embryonic Tissues)
             201B7
    BRIX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BRIX1 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Array including BRIX1: 
              Embryonic Stem Cells in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for BRIX1
    OriGene qSTAR qPCR primer pairs in human, mouse for BRIX1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BRIX1
    QuantiTect SYBR Green Assays in human, mouse, rat BRIX1
    QuantiFast Probe-based Assays in human, mouse, rat BRIX1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRIX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for BRIX1 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Brix11 , 5 BRX1, biogenesis of ribosomes, homolog (S. cerevisiae)1, 5 88.01(n)1
    91.78(a)1
      15 (5.35 cM)5
    678321  NM_026396.31  NP_080672.31 
     104747795 
    chicken
    (Gallus gallus)
    Aves BRIX11 BRX1, biogenesis of ribosomes, homolog (S. cerevisiae) 73.26(n)
    76.16(a)
      427433  NM_001031449.1  NP_001026620.1 
    lizard
    (Anolis carolinensis)
    Reptilia BRIX16
    BRX1, biogenesis of ribosomes, homolog (S. cerevis...
    73(a)
    1 ↔ 1
    GL343241.1(2031442-2039813)
    African clawed frog
    (Xenopus laevis)
    Amphibia AF319877.12   -- 77.19(n)    AF319877.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.97342 Danio rerio cDNA clone IMAGE6789379, partial cds 71.05(n)    BC056279.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG115831 CG11583 58.91(n)
    63.36(a)
      326206  NM_001038900.2  NP_001033989.1 
    worm
    (Caenorhabditis elegans)
    Secernentea K12H4.36
    Protein K12H4.3 (K12H4.3) mRNA, complete cds
    38(a)
    1 ↔ 1
    III(8046034-8047611) WBGene00019678
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BRX1(YOL077C)4
    BRX11
    Nucleolar protein, constituent of 66S pre-ribosomal more4
    BRX11
    57.56(n)1
    50.6(a)1
      15(186723-185848)4
    8540781, 4  NP_014565.21  NP_014565.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G154601 AT3G15460 55.83(n)
    52.08(a)
      820785  NM_112414.3  NP_566514.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g05918001 Os02g0591800 52.8(n)
    48.99(a)
      4329832  NM_001053824.1  NP_001047289.1 


    ENSEMBL Gene Tree for BRIX1 (if available)
    TreeFam Gene Tree for BRIX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BRIX1 gene
    1 SIMAP similar gene for BRIX1 using alignment to 1 protein entry:     BRX1_HUMAN:
    BXDC2

    Find genes that share paralogs with BRIX1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for BRIX1
    PGOHUM00000249656


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BRIX1 (see all 193)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs68610331,2
    C,F,H--34917846(+) TGCAGT/CTAATA 1 -- int128Minor allele frequency- C:0.04NS EA NA CSA WA 2668
    rs1391579121,2
    --34917991(+) AGAGAC/TTGAAG 1 -- int10--------
    rs1915157371,2
    --34918021(+) AGGAGA/GGCATT 1 -- int10--------
    rs1845955341,2
    --34918145(+) GGTGCA/GGTGGT 1 -- int10--------
    rs1891153101,2
    --34918280(+) CATGGC/TGGCAC 1 -- int10--------
    rs374341,2
    C,F,H--34918415(-) GATCTT/CGTTTT 1 -- int129Minor allele frequency- C:0.25NS EA NA WA 3068
    rs2022096881,2
    --34918601(+) ATACTC/TTAGAA 1 -- int10--------
    rs2010845781,2
    C--34918606(+) TTAGAA/GATTTC 1 -- int10--------
    rs412706551,2
    C,F--34918654(-) GAATAT/CATAAA 1 -- int15Minor allele frequency- C:0.01NS WA 278
    rs1815739171,2
    --34918660(+) TATTCC/TTCATT 1 -- int10--------

    HapMap Linkage Disequilibrium report for BRIX1 (34915481 - 34926101 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for BRIX1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv4789CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BRIX1
    DNA2.0 Custom Variant and Variant Library Synthesis for BRIX1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BRIX1 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with BRIX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Brix from Xenopus laevis and brx1p from yeast define a new family of proteins involved in the biogenesis of large ribosomal subunits. (PubMed id 11843177)1, 2 Kaser A.... Kreil G. (Biol. Chem. 2001)
    5. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    6. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    7. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    8. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (Biochem. J. 2013)
    9. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55299 HGNC: 24170 AceView: BRIX Ensembl:ENSG00000113460 euGenes: HUgn55299
    ECgene: BRIX1 H-InvDB: BRIX1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BRIX1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BRIX1 gene:
    Search GeneIP for patents involving BRIX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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