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Aliases for BRIX1 Gene

Aliases for BRIX1 Gene

  • BRX1, Biogenesis Of Ribosomes 2 3 5
  • Brix Domain-Containing Protein 2 3 4
  • Brix Domain Containing 2 2 3
  • BXDC2 3 4
  • BRIX 3 4
  • BRX1, Biogenesis Of Ribosomes, Homolog (S. Cerevisiae) 2
  • Ribosome Biogenesis Protein BRX1 Homolog 3
  • BRX1, Biogenesis Of Ribosomes, Homolog 3

External Ids for BRIX1 Gene

Previous HGNC Symbols for BRIX1 Gene

  • BXDC2

Previous GeneCards Identifiers for BRIX1 Gene

  • GC05P034953

Summaries for BRIX1 Gene

GeneCards Summary for BRIX1 Gene

BRIX1 (BRX1, Biogenesis Of Ribosomes) is a Protein Coding gene. Among its related pathways are Gastric cancer network 2. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for BRIX1 Gene

  • Required for biogenesis of the 60S ribosomal subunit.

Gene Wiki entry for BRIX1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRIX1 Gene

Genomics for BRIX1 Gene

Regulatory Elements for BRIX1 Gene

Enhancers for BRIX1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around BRIX1 on UCSC Golden Path with GeneCards custom track

Promoters for BRIX1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for BRIX1 Gene

Chromosome:
5
Start:
34,915,376 bp from pter
End:
34,925,996 bp from pter
Size:
10,621 bases
Orientation:
Plus strand

Genomic View for BRIX1 Gene

Genes around BRIX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRIX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRIX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRIX1 Gene

Proteins for BRIX1 Gene

  • Protein details for BRIX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDN6-BRX1_HUMAN
    Recommended name:
    Ribosome biogenesis protein BRX1 homolog
    Protein Accession:
    Q8TDN6
    Secondary Accessions:
    • A8K0P5
    • Q3ZTT4
    • Q8N453
    • Q96DH1

    Protein attributes for BRIX1 Gene

    Size:
    353 amino acids
    Molecular mass:
    41401 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BRIX1 Gene

Post-translational modifications for BRIX1 Gene

  • Ubiquitination at Lys 276
  • Modification sites at PhosphoSitePlus

Other Protein References for BRIX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for BRIX1 Gene

Domains & Families for BRIX1 Gene

Protein Domains for BRIX1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for BRIX1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TDN6

UniProtKB/Swiss-Prot:

BRX1_HUMAN :
  • Contains 1 Brix domain.
  • Belongs to the BRX1 family.
Domain:
  • Contains 1 Brix domain.
Family:
  • Belongs to the BRX1 family.
genes like me logo Genes that share domains with BRIX1: view

No data available for Gene Families for BRIX1 Gene

Function for BRIX1 Gene

Molecular function for BRIX1 Gene

UniProtKB/Swiss-Prot Function:
Required for biogenesis of the 60S ribosomal subunit.

Gene Ontology (GO) - Molecular Function for BRIX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with BRIX1: view
genes like me logo Genes that share phenotypes with BRIX1: view

Animal Model Products

CRISPR Products

miRNA for BRIX1 Gene

miRTarBase miRNAs that target BRIX1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BRIX1 Gene

Localization for BRIX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRIX1 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BRIX1 Gene COMPARTMENTS Subcellular localization image for BRIX1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for BRIX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with BRIX1: view

Pathways & Interactions for BRIX1 Gene

SuperPathways for BRIX1 Gene

Superpath Contained pathways
1 Gastric cancer network 2
genes like me logo Genes that share pathways with BRIX1: view

Pathways by source for BRIX1 Gene

1 BioSystems pathway for BRIX1 Gene

Gene Ontology (GO) - Biological Process for BRIX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IBA --
genes like me logo Genes that share ontologies with BRIX1: view

No data available for SIGNOR curated interactions for BRIX1 Gene

Drugs & Compounds for BRIX1 Gene

No Compound Related Data Available

Transcripts for BRIX1 Gene

Unigene Clusters for BRIX1 Gene

BRX1, biogenesis of ribosomes, homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BRIX1 Gene

No ASD Table

Relevant External Links for BRIX1 Gene

GeneLoc Exon Structure for
BRIX1
ECgene alternative splicing isoforms for
BRIX1

Expression for BRIX1 Gene

mRNA expression in normal human tissues for BRIX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BRIX1 Gene

This gene is overexpressed in Adrenal (28.9) and Fetal testis (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BRIX1 Gene



Protein tissue co-expression partners for BRIX1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BRIX1 Gene:

BRIX1

SOURCE GeneReport for Unigene cluster for BRIX1 Gene:

Hs.718510
genes like me logo Genes that share expression patterns with BRIX1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BRIX1 Gene

Orthologs for BRIX1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BRIX1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BRIX1 34
  • 92.07 (n)
  • 93.77 (a)
BRIX1 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BRIX1 34
  • 90.06 (n)
  • 89.49 (a)
BRIX1 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Brix1 34
  • 88.01 (n)
  • 91.78 (a)
Brix1 16
Brix1 35
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BRIX1 34
  • 97.95 (n)
  • 97.41 (a)
BRIX1 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Brix1 34
  • 87.03 (n)
  • 91.19 (a)
oppossum
(Monodelphis domestica)
Mammalia BRIX1 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 84 (a)
OneToMany
-- 35
  • 89 (a)
OneToMany
chicken
(Gallus gallus)
Aves BRIX1 34
  • 73.26 (n)
  • 76.16 (a)
BRIX1 35
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BRIX1 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia brix1 34
  • 69.44 (n)
  • 76.79 (a)
zebrafish
(Danio rerio)
Actinopterygii bxdc2 34
  • 63.8 (n)
  • 72.16 (a)
Dr.9734 34
bxdc2 35
  • 57 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005365 34
  • 53.75 (n)
  • 53.98 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11583 34
  • 58.91 (n)
  • 63.36 (a)
CG11583 35
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea K12H4.3 35
  • 38 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER020W 34
  • 53.55 (n)
  • 49.8 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E17799g 34
  • 56.89 (n)
  • 50.2 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BRX1 34
  • 57.56 (n)
  • 50.6 (a)
BRX1 35
  • 45 (a)
OneToOne
BRX1 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G15460 34
  • 55.83 (n)
  • 52.08 (a)
rice
(Oryza sativa)
Liliopsida Os02g0591800 34
  • 52.8 (n)
  • 48.99 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01524 34
  • 52.03 (n)
  • 49.13 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes brx1 34
  • 55.33 (n)
  • 48.18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6852 35
  • 51 (a)
OneToOne
Species where no ortholog for BRIX1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BRIX1 Gene

ENSEMBL:
Gene Tree for BRIX1 (if available)
TreeFam:
Gene Tree for BRIX1 (if available)

Paralogs for BRIX1 Gene

(1) SIMAP similar genes for BRIX1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for BRIX1 Gene

genes like me logo Genes that share paralogs with BRIX1: view

No data available for Paralogs for BRIX1 Gene

Variants for BRIX1 Gene

Sequence variations from dbSNP and Humsavar for BRIX1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs185186 -- 34,920,491(-) tatta(C/T)agcag intron-variant
rs2270934 -- 34,924,752(+) TATCA(A/G)TTATT intron-variant
rs27966 -- 34,925,656(+) TATTT(A/T)ATTTA utr-variant-3-prime
rs57326744 -- 34,923,310(+) GTCTC(A/G/T)CTCTT intron-variant
rs57343458 -- 34,921,927(+) AAAAA(-/A)GGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BRIX1 Gene

Variant ID Type Subtype PubMed ID
dgv5629n100 CNV gain 25217958
esv3604679 CNV gain 21293372
esv3604690 CNV gain 21293372
nsv4789 CNV deletion 18451855
nsv597809 CNV gain 21841781

Variation tolerance for BRIX1 Gene

Residual Variation Intolerance Score: 67.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.17; 80.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BRIX1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BRIX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRIX1 Gene

Disorders for BRIX1 Gene

Relevant External Links for BRIX1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BRIX1

No disorders were found for BRIX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BRIX1 Gene

Publications for BRIX1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  4. Brix from Xenopus laevis and brx1p from yeast define a new family of proteins involved in the biogenesis of large ribosomal subunits. (PMID: 11843177) Kaser A. … Kreil G. (Biol. Chem. 2001) 3 4 65
  5. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3 65

Products for BRIX1 Gene

Sources for BRIX1 Gene

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