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Aliases for BRIX1 Gene

Aliases for BRIX1 Gene

  • BRX1, Biogenesis Of Ribosomes 2 3
  • Brix Domain-Containing Protein 2 3 4
  • Brix Domain Containing 2 2 3
  • BXDC2 3 4
  • BRIX 3 4
  • BRX1, Biogenesis Of Ribosomes, Homolog (S. Cerevisiae) 2
  • Ribosome Biogenesis Protein BRX1 Homolog 3
  • BRX1, Biogenesis Of Ribosomes, Homolog 3

External Ids for BRIX1 Gene

Previous Symbols for BRIX1 Gene

  • BXDC2

Summaries for BRIX1 Gene

GeneCards Summary for BRIX1 Gene

BRIX1 (BRX1, Biogenesis Of Ribosomes) is a Protein Coding gene. Among its related pathways are Gastric cancer network 2.

UniProtKB/Swiss-Prot for BRIX1 Gene

  • Required for biogenesis of the 60S ribosomal subunit

Gene Wiki entry for BRIX1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRIX1 Gene

Genomics for BRIX1 Gene

Genomic Location for BRIX1 Gene

Start:
34,915,376 bp from pter
End:
34,925,996 bp from pter
Size:
10,621 bases
Orientation:
Plus strand

Genomic View for BRIX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BRIX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRIX1 Gene

No data available for Regulatory Elements for BRIX1 Gene

Proteins for BRIX1 Gene

  • Protein details for BRIX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDN6-BRX1_HUMAN
    Recommended name:
    Ribosome biogenesis protein BRX1 homolog
    Protein Accession:
    Q8TDN6
    Secondary Accessions:
    • A8K0P5
    • Q3ZTT4
    • Q8N453
    • Q96DH1

    Protein attributes for BRIX1 Gene

    Size:
    353 amino acids
    Molecular mass:
    41401 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BRIX1 Gene

Proteomics data for BRIX1 Gene at MOPED

Post-translational modifications for BRIX1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys276

Other Protein References for BRIX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BRIX1 Gene

Domains for BRIX1 Gene

Protein Domains for BRIX1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

BRX1_HUMAN
Domain:
  • Contains 1 Brix domain.:
    • Q8TDN6
Family:
  • Belongs to the BRX1 family.:
    • Q8TDN6
genes like me logo Genes that share domains with BRIX1: view

No data available for Gene Families for BRIX1 Gene

Function for BRIX1 Gene

Molecular function for BRIX1 Gene

UniProtKB/Swiss-Prot Function: Required for biogenesis of the 60S ribosomal subunit

Gene Ontology (GO) - Molecular Function for BRIX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with BRIX1: view

Phenotypes for BRIX1 Gene

GenomeRNAi human phenotypes for BRIX1:
genes like me logo Genes that share phenotypes with BRIX1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BRIX1 Gene

Localization for BRIX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRIX1 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BRIX1 Gene COMPARTMENTS Subcellular localization image for BRIX1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for BRIX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with BRIX1: view

Pathways for BRIX1 Gene

SuperPathways for BRIX1 Gene

Superpath Contained pathways
1 Gastric cancer network 2
genes like me logo Genes that share pathways with BRIX1: view

Pathways by source for BRIX1 Gene

1 BioSystems pathway for BRIX1 Gene

Gene Ontology (GO) - Biological Process for BRIX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IBA --
GO:0042254 ribosome biogenesis --
genes like me logo Genes that share ontologies with BRIX1: view

Transcripts for BRIX1 Gene

Unigene Clusters for BRIX1 Gene

BRX1, biogenesis of ribosomes, homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BRIX1 Gene

No ASD Table

Relevant External Links for BRIX1 Gene

GeneLoc Exon Structure for
BRIX1
ECgene alternative splicing isoforms for
BRIX1

Expression for BRIX1 Gene

mRNA expression in normal human tissues for BRIX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BRIX1 Gene

SOURCE GeneReport for Unigene cluster for BRIX1 Gene Hs.718510

genes like me logo Genes that share expressions with BRIX1: view

Orthologs for BRIX1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BRIX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BRIX1 36
  • 97.95 (n)
  • 97.41 (a)
BRIX1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BRIX1 36
  • 92.07 (n)
  • 93.77 (a)
BRIX1 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BRIX1 36
  • 90.06 (n)
  • 89.49 (a)
BRIX1 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Brix1 36
  • 88.01 (n)
  • 91.78 (a)
Brix1 16
Brix1 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BRIX1 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 84 (a)
OneToMany
-- 37
  • 89 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Brix1 36
  • 87.03 (n)
  • 91.19 (a)
chicken
(Gallus gallus)
Aves BRIX1 36
  • 73.26 (n)
  • 76.16 (a)
BRIX1 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BRIX1 37
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia brix1 36
  • 69.44 (n)
  • 76.79 (a)
zebrafish
(Danio rerio)
Actinopterygii bxdc2 36
  • 63.8 (n)
  • 72.16 (a)
bxdc2 37
  • 57 (a)
OneToOne
Dr.9734 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005365 36
  • 53.75 (n)
  • 53.98 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11583 36
  • 58.91 (n)
  • 63.36 (a)
CG11583 37
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea K12H4.3 37
  • 38 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER020W 36
  • 53.55 (n)
  • 49.8 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BRX1 36
  • 57.56 (n)
  • 50.6 (a)
BRX1 37
  • 45 (a)
OneToOne
BRX1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E17799g 36
  • 56.89 (n)
  • 50.2 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G15460 36
  • 55.83 (n)
  • 52.08 (a)
rice
(Oryza sativa)
Liliopsida Os02g0591800 36
  • 52.8 (n)
  • 48.99 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01524 36
  • 52.03 (n)
  • 49.13 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes brx1 36
  • 55.33 (n)
  • 48.18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6852 37
  • 51 (a)
OneToOne
Species with no ortholog for BRIX1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BRIX1 Gene

ENSEMBL:
Gene Tree for BRIX1 (if available)
TreeFam:
Gene Tree for BRIX1 (if available)

Paralogs for BRIX1 Gene

Selected SIMAP similar genes for BRIX1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for BRIX1 Gene

genes like me logo Genes that share paralogs with BRIX1: view

No data available for Paralogs for BRIX1 Gene

Variants for BRIX1 Gene

Sequence variations from dbSNP and Humsavar for BRIX1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs27966 -- 34,925,656(+) TATTT(A/T)ATTTA utr-variant-3-prime
rs37431 -- 34,923,330(-) TGCAG(G/T)CCAGC intron-variant
rs37432 -- 34,922,851(-) AACTA(A/C)ATTGA intron-variant
rs37433 -- 34,920,152(-) AGCAT(A/G)ATACT intron-variant
rs37434 -- 34,918,310(-) GATCT(C/T)GTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BRIX1 Gene

Variant ID Type Subtype PubMed ID
nsv4789 CNV Loss 18451855

Relevant External Links for BRIX1 Gene

HapMap Linkage Disequilibrium report
BRIX1

Disorders for BRIX1 Gene

No disorders were found for BRIX1 Gene.

No data available for UniProtKB/Swiss-Prot for BRIX1 Gene

Publications for BRIX1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Brix from Xenopus laevis and brx1p from yeast define a new family of proteins involved in the biogenesis of large ribosomal subunits. (PMID: 11843177) Kaser A. … Kreil G. (Biol. Chem. 2001) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  5. Proteomic analysis of human Nop56p-associated pre-ribosomal ribonucleoprotein complexes. Possible link between Nop56p and the nucleolar protein treacle responsible for Treacher Collins syndrome. (PMID: 12777385) Hayano T. … Takahashi N. (J. Biol. Chem. 2003) 3

Products for BRIX1 Gene

Sources for BRIX1 Gene

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