Aliases for BRIP1 Gene
External Ids for BRIP1 Gene
The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations. [provided by RefSeq, Jul 2008]
GeneCards Summary for BRIP1 Gene
BRIP1 (BRCA1 Interacting Protein C-Terminal Helicase 1) is a Protein Coding gene. Diseases associated with BRIP1 include fanconi anemia, complementation group j and brip1-related breast cancer. Among its related pathways are Cell Cycle / Checkpoint Control and Metabolism. GO annotations related to this gene include 4 iron, 4 sulfur cluster binding and ATP-dependent DNA helicase activity. An important paralog of this gene is RTEL1.
UniProtKB/Swiss-Prot for BRIP1 Gene
DNA-dependent ATPase and 5 to 3 DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1.