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BRIP1 Gene

protein-coding   GIFtS: 65

GC17M057114
BRCA1 interacting protein C-terminal helicase 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
BACH1 1, 2, 3, 5
EC 3.6.1.- 3
FANCJ 1, 2, 3, 5
FLJ90232 2
MGC126521 2
MGC126523 2
OF 1, 2
Descriptions
ATP-dependent RNA helicase BRIP1 3
BRCA1 interacting protein C-terminal helicase 1 2
BRCA1-associated C-terminal helicase 1 2, 3
BRCA1-binding helicase-like protein BACH1 2
BRCA1-interacting protein 1 2, 3
BRCA1-interacting protein C-terminal helicase 1 3
Protein FACJ 3
External Ids
HGNC: 204731
Entrez Gene: 839902
UniProtKB: Q9BX633
Ensembl: ENSG000001364927
Search outside databases for aliases for BRIP1 gene

Previous GC identifers: GC17M059523 GC17M062245 GC17M060101 GC17M060234

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for BRIP1:
The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with
the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal
double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of
germline cancer-inducing mutations. [provided by RefSeq]

UniProtKB/Swiss-Prot: FANCJ_HUMAN, Q9BX63
Function: DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of
chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination.
Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that
depends on its association with BRCA1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the BRIP1 gene  

Entrez Gene cytogenetic band: 17q22-q24   Ensembl cytogenetic band:  17q23.2   HGNC cytogenetic band: 17q22.2

BRIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M057114:     (about GC identifiers)

Start:
57,114,767 bp from pter
End:
57,295,537 bp from pter
Size:
180,771 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000017.9  NT_010783.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: FANCJ_HUMAN, Q9BX63 (See protein sequence)
Recommended Name: Fanconi anemia group J protein  
Size: 1249 amino acids; 140878 Da
Subunit: Binds directly to the BRCT domains of BRCA1
Subcellular location: Nucleus
PDB structures from and Proteopedia :
1T29 (3D)    
Secondary accessions: Q3MJE2 Q8NCI5
Alternative splicing: 2 isoforms:  Q9BX63-1   Q9BX63-2   

Post-translational modifications:

  • Phosphorylated. Phosphorylation is necessary for interaction with BRCA1, and is cell-cycle
    regulated1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_114432.1  

    ENSEMBL proteins: 
    ENSP00000259008 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (BACH1/BRIP1)
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus NAS11301010
    GO:0005737 cytoplasm IDA14504288
    About this table

    Antibodies for BRIP1: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of BRIP1
    Sigma-Aldrich Antibody Arrays and Antibodies for BRIP1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for BRIP1  (bach1)
    Antibodies from Abcam (BACH1/BRIP1), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Novus Biologicals Antibodies for FANCJ

    Assays for BRIP1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/6 InterPro domains/families (see all 6 ):
     IPR014013 Helic_SF1/SF2_ATP-bd_DinG/Rad3
     IPR006555 Helicase_ATP-dep_c2
     IPR010614 DEAD_2
     IPR002464 DNA/RNA_helicase_DEAH_CS
     IPR014001 DEAD-like_N


       GeneDecks  BRIP1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9BX63

    ProtoNet protein and cluster: Q9BX63

    3 Blocks protein families:
    IPB002464 ATP-dependent helicase
    IPB006555 Helicase c2
    IPB010614 DEAD_2


    UniProtKB/Swiss-Prot: FANCJ_HUMAN, Q9BX63
    Similarity: Belongs to the DEAD box helicase family. DEAH subfamily
    Similarity: Contains 1 helicase ATP-binding domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (BRIP1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (BRIP1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032043

                  Applied Biosystems Silencer® siRNAs for BRIP1

                  Sigma-Aldrich siRNA and siRNA Panels for BRIP1  
                         Sigma-Aldrich shRNA Panels and shRNA for BRIP1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_032043
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_032043
                                     untagged cDNA clone in CMV expression vector: NM_032043 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_032043

    UniProtKB/Swiss-Prot: FANCJ_HUMAN, Q9BX63
    Function: DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of
    chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination.
    Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that
    depends on its association with BRCA1
    Enzyme Number (IUBMB): EC 3.6.1.- 

    5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0003677 DNA binding NAS15878853
    GO:0004003 ATP-dependent DNA helicase activity NAS11301010
    GO:0004386 helicase activity IEA--
    GO:0005515 protein binding IPI11301010 14576433
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    2 Invitrogen iPath™ Online BioAtlas - Pathways for BRIP1 (Maps provided by GeneGo):
     Cell Cycle Regulation by Brca1
     Role of Brca1 and Brca2 in DNA repair

       GeneDecks  BRIP1 for the pathways selected above  
    About GeneDecksing

    1 Millipore Pathway for BRIP1
     DNA damage Role of Brca1 and Brca2 in DNA repair

       GeneDecks  BRIP1 for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  BRIP1 


    5/15 Interacting proteins for BRIP1 (ENSP000002590083 Q9BX632) via UniProtKB, MINT, and/or STRING (see all 15 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MLH1P406922STRING (score=.775) MINT-5115529 MINT-5115470 MINT-5115499 MINT-5115319 MINT-5115375 MINT-5115489 MINT-5115552 MINT-5115348 MINT-5115512 MINT-5115404 MINT-5115429
    BRCA1P383982STRING (score=.999) MINT-19306 MINT-19307 MINT-5115454 MINT-19369 MINT-5115319 MINT-5115375 MINT-5115552 MINT-19368 MINT-5115303 MINT-5115348
    PMS2P542782STRING (score=.778) MINT-5115348 MINT-5115404 MINT-5115319 MINT-5115375
    FANCD2ENSP000002876473STRING (score=.967)
    PALB2ENSP000002615843STRING (score=.961)
    About this table

    5 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000077 DNA damage checkpoint NAS14576433
    GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process IEA--
    GO:0006302 double-strand break repair NAS11301010
    GO:0006357 regulation of transcription from RNA polymerase II promoter IDA14504288
    GO:0006974 response to DNA damage stimulus IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for BRIP1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (BRIP1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (BRIP1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032043

                  Sigma-Aldrich siRNA and siRNA Panels for BRIP1  
                         Sigma-Aldrich shRNA Panels and shRNA for BRIP1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_032043  

    REFSEQ mRNAs for BRIP1 gene: 

    NM_032043.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_032043  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_032043
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_032043
                                     untagged cDNA clone in CMV expression vector: NM_032043 

    Additional cDNA sequence: 

    AF360549.1 AK074713.1 BC101472.1 BC101474.1 

    5 DOTS entries:

    DT.97838492  DT.204369  DT.97838493  DT.40130395  DT.92001121 

    7 AceView cDNA sequences:

    BX473990 BP352179 BU658463 BQ307287 BF799785 BQ308528 BQ309228 

    highest scoring ESTs for BRIP1:

    AF360549 AI218496 BX473990 AI200753 AL135444 AW197766 AW499597 AW500810 BE082523 BE082528 

    Unigene Cluster for BRIP1:

    BRCA1 interacting protein C-terminal helicase 1
    Hs.532799  [show with all ESTs]
    Unigene Representative Sequence: AF360549


    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for BRIP1

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21
    SP1:                                                                                                                          -                       -         
    SP2:                                                                                                                          -                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    About this scheme

    ECgene alternative splicing isoforms for BRIP1

    1 Ensembl transcript including schematic representation:
    ENST00000259008  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    BRIP1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for BRIP1

    1 / 2 / 3

    3 probe-sets matching BRIP1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    62361_at2, 3 U95-C 1 1.00 1.00 1.00 1.00 AI218496 0.80 1.00 0.91 1

    221703_at2, 3 U133-A 1 1.00 1.00 -- -- AF360549 0.80 1.00 0.91 1

    221703_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: AAATAGAAAT

    SOURCE GeneReport for Unigene cluster: Hs.532799

    UniProtKB/Swiss-Prot: FANCJ_HUMAN, Q9BX63
    Tissue specificity: Ubiquitously expressed, with highest levels in testis

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for BRIP1 gene from 5/10 species (see all 10 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    BRIP11   -- BRCA1 interacting protein C-terminal helicase 1 88.7(n)
    84.25(a)
    491122  XM_847556.1  XP_852649.1 
    chimpanzee
    (Pan troglodytes)
    BRIP11   -- BRCA1 interacting protein C-terminal helicase 1 99.63(n)
    99.68(a)
    454796  XM_511607.2  XP_511607.2 
    rat
    (Rattus norvegicus)
    Brip11   -- BRCA1 interacting protein C-terminal helicase 1 80.08(n)
    74.96(a)
    360588  XM_340869.3  XP_340870.3 
    mouse
    (Mus musculus)
    Brip11, 5 115
    BRCA1 interacting protein C-terminal helicase 11, 5 80.71(n)1
    75.37(a)1
    2379111  NM_178309.11  NP_840094.11 
     AK0140365  AK0332055  (see all 17)
    chicken
    (Gallus gallus)
    BRIP11   -- BRCA1 interacting protein C-terminal helicase 1 64.49(n)
    57.35(a)
    417642  NM_001033058.1  NP_001028230.1 
    About this table        Species with no ortholog for BRIP1

    ENSEMBL Gene Tree for BRIP1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for BRIP1 gene
    DDX122  DDX112  RTEL12  ERCC22  ENSG000001117882  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/768 NCBI SNPs in BRIP1 are shown (see all 768 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 179)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 17 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs65040751,2
    A,C,F,H57296322(+) GAAAAG/TGAGGT 1 -- ng31 trp37Minor allele frequency- T:0.08EU EA WA NA 562
    rs49867641,2
    A,C,F,H57118129(-) GTACCC/TCACCT 1 P/S mis1 ese319Minor allele frequency- T:0.33MN CSAM EA NA EU WA 1678
    rs20487181,2
    A,C,F,H57295601(+) CAGGAC/TTGGGG 1 -- ng3114Minor allele frequency- T:0.50EU EA WA NA MN CSAM 1352
    rs72134301,2
    A,C,F,H57114956(+) GGACAA/GTACTT 1 -- ut314Minor allele frequency- G:0.32EU EA WA 418
    --
    rs49883471,2
    C,F,H57279287(-) AAAACT/CCAACT 1 P/L mis1 ese315Minor allele frequency- C:0.12NA EU MN CSAM EA WA 1546
    rs49883451,2
    C,F,H57279354(-) GAAAAC/TGTCAT 1 R/C mis1 ese315Minor allele frequency- T:0.00NA EU EA WA MN CSAM 1554
    --
    rs49883461,2
    C,F,H57279294(-) AGACTG/ATAAAA 1 I/V mis115Minor allele frequency- A:0.00NA EU MN CSAM EA WA 1546
    --
    rs19781111,2
    A,C,F57115281(-) GGtttC/Tttttt 1 -- ut31 trp31Minor allele frequency- T:0.40NA 120
    rs289030981,2
    C,F57292005(-) AGAGTC/GCCACA 1 P/A mis1 ese35Minor allele frequency- G:0.01EU EA WA 612
    rs289975721,2
    C,F57212440(-) ACTATC/GCAGCT 1 I/M mis15Minor allele frequency- G:0.35EU EA WA 610
    About this table

    HapMap Linkage Disequilibrium images for BRIP1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 605882   disorders: 114480  609054  

    UniProtKB/Swiss-Prot: FANCJ_HUMAN, Q9BX63

  • Defects in BRIP1 are a cause of susceptibility to breast cancer (BC) [MIM:114480]. BC is
    an extremely common malignancy, affecting one in eight women during their lifetime. A positive
    family history has been identified as major contributor to risk of development of the disease, and
    this link is striking for early-onset breast cancer
  • Defects in BRIP1 are the cause of Fanconi anemia complementation group J (FANCJ)
    [MIM:609054, 227650]. Fanconi anemia (FA) is a genetically heterogeneous, autosomal recessive
    disorder characterized by progressive pancytopenia, a diverse assortment of congenital
    malformations, and a predisposition to the development of malignancies. At the cellular level it
    is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased
    chromosome breakage), and defective DNA repair
  • 6 Novoseek disease relationships for BRIP1 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    fanconis anemia 84.92 8 16153896 (2), 18414782 (1), 16357529 (1), 17145708 (1) (see all 5)
    breast cancer 59.14 34 16430786 (5), 18414782 (3), 18628483 (3), 14983014 (3) (see all 12)
    ovarian cancer 40.42 6 12565990 (3), 18628483 (1), 14983014 (1), 16430786 (1)
    cancer 30.87 1 16462773 (1)
    anemia 16.68 3 17768402 (1), 17504528 (1)
    tumors 13.00 12 18345034 (2), 14983014 (2), 18628483 (1), 16462773 (1) (see all 7)
    About this table

    GeneTests: BRIP1
    Fanconi Anemia

    Human Gene Mutation Database: BRIP1
    Genetic Association Database: BRIP1
    Human Genome Epidemiology Navigator: BRIP1 (19 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/70 PubMed articles for BRIP1 gene (see all 70 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 83990 HGNC: 20473 AceView: BRIP1.1 Ensembl:ENSG00000136492 euGenes: HUgn83990
    ECgene: BRIP1 H-InvDB: BRIP1
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for BRIP1 Genetics and Cytogenetics in Oncology and Haematology
    Fanconi Anemia Mutation Databasehttp://www.rockefeller.edu/fanconi/mutate/jumpj.html
    GeneReviewshttp://www.genetests.org/query?gene=BRIP1
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for BRIP1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for BRIP1-related products

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     Predesigned and custom siRNAs for BRIP1 Antibodies for BRIP1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for BRIP1 Browse small molecules at Sigma-Aldrich
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