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BRIP1 Gene

protein-coding GIFtS: 65

GC17M057114

BRCA1 interacting protein C-terminal helicase 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BACH1 ^¹, ², ³, ⁵
EC 3.6.1.- ^³
FANCJ ^¹, ², ³, ⁵
FLJ90232 ^²
MGC126521 ^²
MGC126523 ^²
OF ^¹, ²

Descriptions
ATP-dependent RNA helicase BRIP1 ^³
BRCA1 interacting protein C-terminal helicase 1 ^²
BRCA1-associated C-terminal helicase 1 ^², ³
BRCA1-binding helicase-like protein BACH1 ^²
BRCA1-interacting protein 1 ^², ³
BRCA1-interacting protein C-terminal helicase 1 ^³
Protein FACJ ^³

External Ids
HGNC: 20473¹
Entrez Gene: 83990²
UniProtKB: Q9BX63³
Ensembl: ENSG00000136492⁷

Search outside databases for aliases for BRIP1 gene

Previous GC identifers: GC17M059523 GC17M062245 GC17M060101 GC17M060234

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for BRIP1:

The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with

the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal

double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of

germline cancer-inducing mutations. [provided by RefSeq]

UniProtKB/Swiss-Prot: FANCJ_HUMAN, Q9BX63

Function: DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of

chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination.

Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that

depends on its association with BRCA1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the BRIP1 gene

Entrez Gene cytogenetic band: 17q22-q24 Ensembl cytogenetic band: 17q23.2 HGNC cytogenetic band: 17q22.2

BRIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M057114: (about GC identifiers)

Start:	57,114,767 bp from pter
End:	57,295,537 bp from pter
Size:	180,771 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000017.9 NT_010783.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: FANCJ_HUMAN, Q9BX63 (See protein sequence)

Recommended Name: Fanconi anemia group J protein

Size: 1249 amino acids; 140878 Da

Subunit: Binds directly to the BRCT domains of BRCA1

Subcellular location: Nucleus

PDB structures from and Proteopedia :

1T29 (3D)

Secondary accessions: Q3MJE2 Q8NCI5

Alternative splicing: 2 isoforms: Q9BX63-1 Q9BX63-2

Post-translational modifications:

Phosphorylated. Phosphorylation is necessary for interaction with BRCA1, and is cell-cycle

regulated¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_114432.1

ENSEMBL proteins:

ENSP00000259008

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (BACH1/BRIP1)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	NAS	11301010
GO:0005737	cytoplasm	IDA	14504288

About this table

Antibodies for BRIP1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of BRIP1
	Sigma-Aldrich Antibody Arrays and Antibodies for BRIP1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for BRIP1 (bach1)
	Antibodies from Abcam (BACH1/BRIP1), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for FANCJ

Assays for BRIP1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9BX63

ProtoNet protein and cluster: Q9BX63

3 Blocks protein families:

IPB002464 ATP-dependent helicase

IPB006555 Helicase c2

IPB010614 DEAD_2

UniProtKB/Swiss-Prot: FANCJ_HUMAN, Q9BX63

Similarity: Belongs to the DEAD box helicase family. DEAH subfamily

Similarity: Contains 1 helicase ATP-binding domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BRIP1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BRIP1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032043

Applied Biosystems Silencer® siRNAs for BRIP1

Sigma-Aldrich siRNA and siRNA Panels for BRIP1

Sigma-Aldrich shRNA Panels and shRNA for BRIP1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_032043
Myc/DDK tagged cDNA clone in CMV expression vector: NM_032043
untagged cDNA clone in CMV expression vector: NM_032043

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_032043

UniProtKB/Swiss-Prot: FANCJ_HUMAN, Q9BX63

Function: DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of

chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination.

Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that

depends on its association with BRCA1

Enzyme Number (IUBMB): EC 3.6.1.-

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003677	DNA binding	NAS	15878853
GO:0004003	ATP-dependent DNA helicase activity	NAS	11301010
GO:0004386	helicase activity	IEA	--
GO:0005515	protein binding	IPI	11301010 14576433

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for BRIP1

5/15 Interacting proteins for BRIP1 (ENSP00000259008³ Q9BX63²) via UniProtKB, MINT, and/or STRING (see all 15 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MLH1	P40692²	STRING (score=.775) MINT-5115529 MINT-5115470 MINT-5115499 MINT-5115319 MINT-5115375 MINT-5115489 MINT-5115552 MINT-5115348 MINT-5115512 MINT-5115404 MINT-5115429
BRCA1	P38398²	STRING (score=.999) MINT-19306 MINT-19307 MINT-5115454 MINT-19369 MINT-5115319 MINT-5115375 MINT-5115552 MINT-19368 MINT-5115303 MINT-5115348
PMS2	P54278²	STRING (score=.778) MINT-5115348 MINT-5115404 MINT-5115319 MINT-5115375
FANCD2	ENSP00000287647³	STRING (score=.967)
PALB2	ENSP00000261584³	STRING (score=.961)

About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000077	DNA damage checkpoint	NAS	14576433
GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	IEA	--
GO:0006302	double-strand break repair	NAS	11301010
GO:0006357	regulation of transcription from RNA polymerase II promoter	IDA	14504288
GO:0006974	response to DNA damage stimulus	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for BRIP1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BRIP1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (BRIP1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032043

Sigma-Aldrich siRNA and siRNA Panels for BRIP1

Sigma-Aldrich shRNA Panels and shRNA for BRIP1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_032043

REFSEQ mRNAs for BRIP1 gene:

NM_032043.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_032043

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_032043
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_032043
                                 untagged cDNA clone in CMV expression vector: NM_032043

Additional cDNA sequence:

AF360549.1 AK074713.1 BC101472.1 BC101474.1

5 DOTS entries:

DT.97838492 DT.204369 DT.97838493 DT.40130395 DT.92001121

7 AceView cDNA sequences:

BX473990 BP352179 BU658463 BQ307287 BF799785 BQ308528 BQ309228

highest scoring ESTs for BRIP1:

AF360549 AI218496 BX473990 AI200753 AL135444 AW197766 AW499597 AW500810 BE082523 BE082528

Unigene Cluster for BRIP1:

BRCA1 interacting protein C-terminal helicase 1

Hs.532799 [show with all ESTs]

Unigene Representative Sequence: AF360549

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for BRIP1

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	·	4c	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20a	·	20b	^	21
SP1:																																									-								-
SP2:																																									-
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for BRIP1

1 Ensembl transcript including schematic representation:

ENST00000259008

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

BRIP1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for BRIP1

¹ / ² / ³

3 probe-sets matching BRIP1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
62361_at²^{, 3}	U95-C	1	1.00	1.00	1.00	1.00	AI218496	0.80	1.00	0.91	1
221703_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF360549	0.80	1.00	0.91	1
221703_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAATAGAAAT

SOURCE GeneReport for Unigene cluster: Hs.532799
UniProtKB/Swiss-Prot: FANCJ_HUMAN, Q9BX63
Tissue specificity: Ubiquitously expressed, with highest levels in testis

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for BRIP1 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	BRIP1¹	--	BRCA1 interacting protein C-terminal helicase 1	88.7(n) 84.25(a)	491122 XM_847556.1 XP_852649.1
chimpanzee (Pan troglodytes)	BRIP1¹	--	BRCA1 interacting protein C-terminal helicase 1	99.63(n) 99.68(a)	454796 XM_511607.2 XP_511607.2
rat (Rattus norvegicus)	Brip1¹	--	BRCA1 interacting protein C-terminal helicase 1	80.08(n) 74.96(a)	360588 XM_340869.3 XP_340870.3
mouse (Mus musculus)	Brip1^{1, 5}	11⁵	BRCA1 interacting protein C-terminal helicase 1^{1, 5}	80.71(n)¹ 75.37(a)¹	237911¹ NM_178309.1¹ NP_840094.1¹ AK014036⁵ AK033205⁵ (see all 17)
chicken (Gallus gallus)	BRIP1¹	--	BRCA1 interacting protein C-terminal helicase 1	64.49(n) 57.35(a)	417642 NM_001033058.1 NP_001028230.1

About this table Species with no ortholog for BRIP1

ENSEMBL Gene Tree for BRIP1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for BRIP1 gene

DDX12² DDX11² RTEL1² ERCC2² ENSG00000111788²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/768 NCBI SNPs in BRIP1 are shown (see all 768 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 179)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs6504075^1,2	A,C,F,H	57296322(+)	`GAAAAG/TGAGGT`	1	--	ng3¹ trp³		7	EU EA WA NA	562
	rs4986764^1,2	A,C,F,H	57118129(-)	`GTACCC/TCACCT`	1	P/S	mis¹ ese³		19	MN CSAM EA NA EU WA	1678
	rs2048718^1,2	A,C,F,H	57295601(+)	`CAGGAC/TTGGGG`	1	--	ng3¹		14	EU EA WA NA MN CSAM	1352
	rs7213430^1,2	A,C,F,H	57114956(+)	`GGACAA/GTACTT`	1	--	ut3¹		4	EU EA WA	418
--	rs4988347^1,2	C,F,H	57279287(-)	`AAAACT/CCAACT`	1	P/L	mis¹ ese³		15	NA EU MN CSAM EA WA	1546
	rs4988345^1,2	C,F,H	57279354(-)	`GAAAAC/TGTCAT`	1	R/C	mis¹ ese³		15	NA EU EA WA MN CSAM	1554
--	rs4988346^1,2	C,F,H	57279294(-)	`AGACTG/ATAAAA`	1	I/V	mis¹		15	NA EU MN CSAM EA WA	1546
--	rs1978111^1,2	A,C,F	57115281(-)	`GGtttC/Tttttt`	1	--	ut3¹ trp³		1	NA	120
	rs28903098^1,2	C,F	57292005(-)	`AGAGTC/GCCACA`	1	P/A	mis¹ ese³		5	EU EA WA	612
	rs28997572^1,2	C,F	57212440(-)	`ACTATC/GCAGCT`	1	I/M	mis¹		5	EU EA WA	610

About this table

HapMap Linkage Disequilibrium images for BRIP1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605882 disorders: 114480 609054

UniProtKB/Swiss-Prot: FANCJ_HUMAN, Q9BX63

Defects in BRIP1 are a cause of susceptibility to breast cancer (BC) [MIM:114480]. BC is

an extremely common malignancy, affecting one in eight women during their lifetime. A positive

family history has been identified as major contributor to risk of development of the disease, and

this link is striking for early-onset breast cancer

Defects in BRIP1 are the cause of Fanconi anemia complementation group J (FANCJ)

[MIM:609054, 227650]. Fanconi anemia (FA) is a genetically heterogeneous, autosomal recessive

disorder characterized by progressive pancytopenia, a diverse assortment of congenital

malformations, and a predisposition to the development of malignancies. At the cellular level it

is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased

chromosome breakage), and defective DNA repair

6 Novoseek disease relationships for BRIP1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
fanconis anemia	84.92	8	16153896 (2), 18414782 (1), 16357529 (1), 17145708 (1) (see all 5)
breast cancer	59.14	34	16430786 (5), 18414782 (3), 18628483 (3), 14983014 (3) (see all 12)
ovarian cancer	40.42	6	12565990 (3), 18628483 (1), 14983014 (1), 16430786 (1)
cancer	30.87	1	16462773 (1)
anemia	16.68	3	17768402 (1), 17504528 (1)
tumors	13.00	12	18345034 (2), 14983014 (2), 18628483 (1), 16462773 (1) (see all 7)

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GeneTests: BRIP1

Fanconi Anemia

Human Gene Mutation Database: BRIP1
Genetic Association Database: BRIP1
Human Genome Epidemiology Navigator: BRIP1 (19 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/70 PubMed articles for BRIP1 gene (see all 70 ):

BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function. (PubMed id 11301010)^{1, 2, 3, 4} Cantor S.B....Livingston D.M. (2001)
The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations. (PubMed id 14983014)^{1, 3, 4} Cantor S.B....Livingston D.M. (2004)
No evidence of involvement of germline BACH1 mutations in Finnish breast and ovarian cancer families. (PubMed id 12565990)^{1, 3, 4} Karppinen S.-M.... Winqvist R. (2003)
BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ. (PubMed id 16153896)^{1, 3, 4} Litman R.... Cantor S.B. (2005)
Kin-cohort estimates for familial breast cancer risk in relation to variants in DNA base excision repair, BRCA1 interacting and growth factor genes. (PubMed id 15113441)^{1, 3, 6} Sigurdson A.J....Struewing J.P. (2004)
SUVi and BACH1: a new subfamily of mammalian helicases? (PubMed id 11595410)^{1, 2, 3} Menichini P. and Linial M. (2001)
The BRCT domain is a phospho-protein binding domain. (PubMed id 14576433)^{1, 3, 4} Yu X.... Chen J. (2003)
No mutations in the BACH1 gene in BRCA1 and BRCA2 negative breast- cancer families linked to 17q22. (PubMed id 11920628)^{1, 3, 4} Luo L.... Lindblom A. (2002)
The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair. (PubMed id 16116421)^{1, 3, 4} Bridge W.L.... Hiom K. (2005)
The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia. (PubMed id 16116424)^{1, 3, 4} Levran O.... Auerbach A.D. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 83990	HGNC: 20473	AceView: BRIP1.1	Ensembl:ENSG00000136492	euGenes: HUgn83990
ECgene: BRIP1	H-InvDB: BRIP1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for BRIP1	Genetics and Cytogenetics in Oncology and Haematology
Fanconi Anemia Mutation Database	http://www.rockefeller.edu/fanconi/mutate/jumpj.html
GeneReviews	http://www.genetests.org/query?gene=BRIP1

Licensable Technologies for BRIP1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for BRIP1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for BRIP1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for BRIP1		Antibodies for BRIP1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for BRIP1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Antibodies & Assays for BRIP1 (bach1)

	Recombinant Proteins (BACH1/BRIP1)
	Antibodies (BACH1/BRIP1)

Search OriGene for BRIP1

Search Tocris compounds for BRIP1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for FANCJ

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BRIP1 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for BRIP1

Summaries
for BRIP1

Genomic Location
for BRIP1

Proteins
for BRIP1

Protein Domains/
Families
for BRIP1

Gene Function
for BRIP1

Pathways & Interactions
for BRIP1

Drugs & Compounds
for BRIP1

Transcripts
for BRIP1

Expression
for BRIP1

Orthologs
for BRIP1

Paralogs
for BRIP1

SNPs/Variants
for BRIP1

Disorders & Mutations
for BRIP1

Medical News
for BRIP1

Publications
for BRIP1

Search for BRIP1

Genome Databases showing BRIP1

Other Databases showing BRIP1

Specialized Databases showing BRIP1

Licensable Technologies
for BRIP1

Services
for BRIP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

BRIP1 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor BRIP1

Summariesfor BRIP1

Genomic Locationfor BRIP1

Proteinsfor BRIP1

Protein Domains/Familiesfor BRIP1

Gene Functionfor BRIP1

Pathways & Interactionsfor BRIP1

Drugs & Compoundsfor BRIP1

Transcriptsfor BRIP1

Expression for BRIP1

Orthologsfor BRIP1

Paralogsfor BRIP1

SNPs/Variantsfor BRIP1

Disorders & Mutationsfor BRIP1

Medical Newsfor BRIP1

Publicationsfor BRIP1

Search for BRIP1

Genome Databases showing BRIP1

Other Databases showing BRIP1

Specialized Databases showing BRIP1

Licensable Technologiesfor BRIP1

Servicesfor BRIP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for BRIP1

Summaries
for BRIP1

Genomic Location
for BRIP1

Proteins
for BRIP1

Protein Domains/
Families
for BRIP1

Gene Function
for BRIP1

Pathways & Interactions
for BRIP1

Drugs & Compounds
for BRIP1

Transcripts
for BRIP1

Expression
for BRIP1

Orthologs
for BRIP1

Paralogs
for BRIP1

SNPs/Variants
for BRIP1

Disorders & Mutations
for BRIP1

Medical News
for BRIP1

Publications
for BRIP1

Licensable Technologies
for BRIP1

Services
for BRIP1