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Aliases for BRINP3 Gene

Aliases for BRINP3 Gene

  • Bone Morphogenetic Protein/Retinoic Acid Inducible Neural-Specific 3 2 3
  • Family With Sequence Similarity 5, Member C 2 3
  • DBCCR1-Like Protein 1 3 4
  • DBCCR1L1 3 4
  • DBCCR1L 3 4
  • FAM5C 3 4
  • BMP/Retinoic Acid-Inducible Neural-Specific Protein 3 3
  • Protein FAM5C 3

External Ids for BRINP3 Gene

Previous HGNC Symbols for BRINP3 Gene

  • FAM5C

Summaries for BRINP3 Gene

GeneCards Summary for BRINP3 Gene

BRINP3 (Bone Morphogenetic Protein/Retinoic Acid Inducible Neural-Specific 3) is a Protein Coding gene. Diseases associated with BRINP3 include oligoastrocytoma. An important paralog of this gene is BRINP1.

UniProtKB/Swiss-Prot for BRINP3 Gene

  • Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRINP3 Gene

Genomics for BRINP3 Gene

Genomic Location for BRINP3 Gene

190,097,662 bp from pter
190,478,404 bp from pter
380,743 bases
Minus strand

Genomic View for BRINP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BRINP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRINP3 Gene

No data available for Regulatory Elements for BRINP3 Gene

Proteins for BRINP3 Gene

  • Protein details for BRINP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BMP/retinoic acid-inducible neural-specific protein 3
    Protein Accession:
    Secondary Accessions:
    • B3KVP1
    • B7Z260
    • O95726
    • Q2M330

    Protein attributes for BRINP3 Gene

    766 amino acids
    Molecular mass:
    88445 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BRINP3 Gene


neXtProt entry for BRINP3 Gene

Proteomics data for BRINP3 Gene at MOPED

Post-translational modifications for BRINP3 Gene

  • Ubiquitination at Lys538
  • Glycosylation at Asn168, Asn337, Asn456, Asn562, Asn609, and Asn641
  • Modification sites at PhosphoSitePlus

Other Protein References for BRINP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BRINP3 Gene

Domains for BRINP3 Gene

Protein Domains for BRINP3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q76B58
  • Contains 1 MACPF domain.
  • Belongs to the BRINP family.
genes like me logo Genes that share domains with BRINP3: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for BRINP3 Gene

Function for BRINP3 Gene

Molecular function for BRINP3 Gene

UniProtKB/Swiss-Prot Function: Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development.

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BRINP3 Gene

Localization for BRINP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRINP3 Gene

Secreted. Mitochondrion.

Gene Ontology (GO) - Cellular Components for BRINP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0030425 dendrite IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with BRINP3: view

No data available for Subcellular locations from COMPARTMENTS for BRINP3 Gene

Pathways for BRINP3 Gene

SuperPathways for BRINP3 Gene

No Data Available

Interacting Proteins for BRINP3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000356432 Q76B58-BRNP3_HUMAN for BRINP3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for BRINP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007050 cell cycle arrest IEA --
GO:0007399 nervous system development --
GO:0045666 positive regulation of neuron differentiation ISS --
GO:0045786 negative regulation of cell cycle --
GO:0045930 negative regulation of mitotic cell cycle ISS --
genes like me logo Genes that share ontologies with BRINP3: view

No data available for Pathways by source for BRINP3 Gene

Transcripts for BRINP3 Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BRINP3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BRINP3 Gene

No ASD Table

Relevant External Links for BRINP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BRINP3 Gene

mRNA expression in normal human tissues for BRINP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BRINP3 Gene

This gene is overexpressed in Brain - Hypothalamus (5.1), Brain - Cortex (4.9), Brain - Amygdala (4.3), and Brain - Frontal Cortex (BA9) (4.2).

mRNA Expression by UniProt/SwissProt for BRINP3 Gene

Tissue specificity: Strongly expressed in oral keratinocytes compared to the weak expression in tongue squamous cell carcinoma (SCC). Expressed in endothelial and aortic smooth muscle cells. Overexpressed in gonadotropinomas compared to normal pituitarie tissues.
genes like me logo Genes that share expressions with BRINP3: view

In Situ Assay Products

No data available for Protein expression for BRINP3 Gene

Orthologs for BRINP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BRINP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BRINP3 36
  • 100 (a)
FAM5C 35
  • 99.61 (n)
  • 99.87 (a)
(Bos Taurus)
Mammalia BRINP3 36
  • 98 (a)
FAM5C 35
  • 93.17 (n)
  • 97.91 (a)
(Canis familiaris)
Mammalia BRINP3 36
  • 99 (a)
FAM5C 35
  • 94.73 (n)
  • 98.56 (a)
(Mus musculus)
Mammalia Brinp3 35
  • 91.17 (n)
  • 97.78 (a)
Brinp3 36
  • 98 (a)
Fam5c 16
(Monodelphis domestica)
Mammalia BRINP3 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia BRINP3 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Brinp3 35
  • 90.91 (n)
  • 97.65 (a)
(Gallus gallus)
Aves BRINP3 36
  • 95 (a)
FAM5C 35
  • 86.38 (n)
  • 95.17 (a)
(Anolis carolinensis)
Reptilia BRINP3 36
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam5c 35
  • 81.24 (n)
  • 90.08 (a)
(Danio rerio)
Actinopterygii BRINP3 36
  • 73 (a)
LOC100001603 35
  • 72.12 (n)
  • 77.39 (a)
Species with no ortholog for BRINP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRINP3 Gene

Gene Tree for BRINP3 (if available)
Gene Tree for BRINP3 (if available)

Paralogs for BRINP3 Gene

Paralogs for BRINP3 Gene

Selected SIMAP similar genes for BRINP3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BRINP3: view

Variants for BRINP3 Gene

Sequence variations from dbSNP and Humsavar for BRINP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs17481 -- 190,190,218(-) atttg(C/G)aaaaa intron-variant
rs480692 -- 190,290,531(-) CTGCT(A/G)ATCAG intron-variant
rs489912 -- 190,296,076(+) ttttt(G/T)ggggg intron-variant
rs491055 -- 190,339,704(-) TGGCT(C/T)GTTTT intron-variant
rs491162 -- 190,339,672(+) CCAAC(C/T)GCCTC intron-variant

Relevant External Links for BRINP3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BRINP3 Gene

Disorders for BRINP3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for BRINP3 Gene including...

Search for BRINP3 Gene in MalaCards »
genes like me logo Genes that share disorders with BRINP3: view

No data available for UniProtKB/Swiss-Prot for BRINP3 Gene

Publications for BRINP3 Gene

  1. Expression of the FAM5C in tongue squamous cell carcinoma. (PMID: 19787213) Kuroiwa T. … Shibahara T. (Oncol. Rep. 2009) 3 4
  2. Identification and characterization of novel developmentally regulated neural-specific proteins, BRINP family. (PMID: 15193423) Kawano H. … Matsuoka I. (Brain Res. Mol. Brain Res. 2004) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Id4 and FABP7 are preferentially expressed in cells with astrocytic features in oligodendrogliomas and oligoastrocytomas. (PMID: 16018821) Liang Y. … Gupta N. (BMC Clin Pathol 2005) 2 3
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for BRINP3 Gene

Sources for BRINP3 Gene

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