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Aliases for BRINP3 Gene

Aliases for BRINP3 Gene

  • BMP/Retinoic Acid Inducible Neural Specific 3 2 3
  • Bone Morphogenetic Protein/Retinoic Acid Inducible Neural-Specific 3 2 3 5
  • Family With Sequence Similarity 5, Member C 2 3
  • DBCCR1-Like Protein 1 3 4
  • DBCCR1L1 3 4
  • DBCCR1L 3 4
  • FAM5C 3 4
  • Protein FAM5C 3

External Ids for BRINP3 Gene

Previous HGNC Symbols for BRINP3 Gene

  • FAM5C

Summaries for BRINP3 Gene

Entrez Gene Summary for BRINP3 Gene

  • This gene is overexpressed in pituitary tumors but is underexpressed in tongue squamous cell carcinomas, ulcerative colitis, and peri-implantitis. Polymorphisms that increase expression of this gene have been shown to increase vascular inflammation, and an association of this gene with myocardial infarction has been demonstrated. Finally, hypermethylation of this gene may find usefulness as a biomarker for gastric cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for BRINP3 Gene

BRINP3 (BMP/Retinoic Acid Inducible Neural Specific 3) is a Protein Coding gene. Diseases associated with BRINP3 include tongue squamous cell carcinoma and ulcerative colitis. An important paralog of this gene is BRINP1.

UniProtKB/Swiss-Prot for BRINP3 Gene

  • Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRINP3 Gene

Genomics for BRINP3 Gene

Regulatory Elements for BRINP3 Gene

Promoters for BRINP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BRINP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for BRINP3 Gene

Chromosome:
1
Start:
190,097,662 bp from pter
End:
190,478,404 bp from pter
Size:
380,743 bases
Orientation:
Minus strand

Genomic View for BRINP3 Gene

Genes around BRINP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRINP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRINP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRINP3 Gene

Proteins for BRINP3 Gene

  • Protein details for BRINP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q76B58-BRNP3_HUMAN
    Recommended name:
    BMP/retinoic acid-inducible neural-specific protein 3
    Protein Accession:
    Q76B58
    Secondary Accessions:
    • B3KVP1
    • B7Z260
    • O95726
    • Q2M330

    Protein attributes for BRINP3 Gene

    Size:
    766 amino acids
    Molecular mass:
    88445 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BRINP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BRINP3 Gene

Proteomics data for BRINP3 Gene at MOPED

Post-translational modifications for BRINP3 Gene

  • Glycosylation at Asn 168, Asn 337, Asn 456, Asn 562, Asn 609, and Asn 641
  • Modification sites at PhosphoSitePlus

Other Protein References for BRINP3 Gene

No data available for DME Specific Peptides for BRINP3 Gene

Domains & Families for BRINP3 Gene

Protein Domains for BRINP3 Gene

Suggested Antigen Peptide Sequences for BRINP3 Gene

Graphical View of Domain Structure for InterPro Entry

Q76B58

UniProtKB/Swiss-Prot:

BRNP3_HUMAN :
  • Contains 1 MACPF domain.
  • Belongs to the BRINP family.
Domain:
  • Contains 1 MACPF domain.
Family:
  • Belongs to the BRINP family.
genes like me logo Genes that share domains with BRINP3: view

No data available for Gene Families for BRINP3 Gene

Function for BRINP3 Gene

Molecular function for BRINP3 Gene

UniProtKB/Swiss-Prot Function:
Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development.

Phenotypes for BRINP3 Gene

GenomeRNAi human phenotypes for BRINP3:
genes like me logo Genes that share phenotypes with BRINP3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BRINP3 Gene

Localization for BRINP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRINP3 Gene

Secreted. Mitochondrion.

Gene Ontology (GO) - Cellular Components for BRINP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with BRINP3: view

No data available for Subcellular locations from COMPARTMENTS for BRINP3 Gene

Pathways & Interactions for BRINP3 Gene

SuperPathways for BRINP3 Gene

No Data Available

Interacting Proteins for BRINP3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000356432%0d%0a9606.ENSP00000331201%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000356432 Q76B58-BRNP3_HUMAN for BRINP3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for BRINP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045786 negative regulation of cell cycle IEA --
GO:0045930 negative regulation of mitotic cell cycle IEA,ISS --
genes like me logo Genes that share ontologies with BRINP3: view

No data available for Pathways by source and SIGNOR curated interactions for BRINP3 Gene

Drugs & Compounds for BRINP3 Gene

No Compound Related Data Available

Transcripts for BRINP3 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for BRINP3 Gene

No ASD Table

Relevant External Links for BRINP3 Gene

GeneLoc Exon Structure for
BRINP3
ECgene alternative splicing isoforms for
BRINP3

Expression for BRINP3 Gene

mRNA expression in normal human tissues for BRINP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BRINP3 Gene

This gene is overexpressed in Brain - Hypothalamus (x5.1), Brain - Cortex (x4.9), Brain - Amygdala (x4.3), and Brain - Frontal Cortex (BA9) (x4.2).

mRNA Expression by UniProt/SwissProt for BRINP3 Gene

Q76B58-BRNP3_HUMAN
Tissue specificity: Strongly expressed in oral keratinocytes compared to the weak expression in tongue squamous cell carcinoma (SCC). Expressed in endothelial and aortic smooth muscle cells. Overexpressed in gonadotropinomas compared to normal pituitarie tissues.
genes like me logo Genes that share expression patterns with BRINP3: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for BRINP3 Gene

Orthologs for BRINP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BRINP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM5C 35
  • 99.61 (n)
  • 99.87 (a)
BRINP3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BRINP3 36
  • 98 (a)
OneToOne
FAM5C 35
  • 93.17 (n)
  • 97.91 (a)
dog
(Canis familiaris)
Mammalia FAM5C 35
  • 94.73 (n)
  • 98.56 (a)
BRINP3 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Brinp3 16
Brinp3 36
  • 98 (a)
OneToOne
Brinp3 35
  • 91.17 (n)
  • 97.78 (a)
oppossum
(Monodelphis domestica)
Mammalia BRINP3 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BRINP3 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Brinp3 35
  • 90.91 (n)
  • 97.65 (a)
chicken
(Gallus gallus)
Aves FAM5C 35
  • 86.38 (n)
  • 95.17 (a)
BRINP3 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BRINP3 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam5c 35
  • 81.24 (n)
  • 90.08 (a)
zebrafish
(Danio rerio)
Actinopterygii BRINP3 36
  • 73 (a)
OneToOne
LOC100001603 35
  • 72.12 (n)
  • 77.39 (a)
Species with no ortholog for BRINP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRINP3 Gene

ENSEMBL:
Gene Tree for BRINP3 (if available)
TreeFam:
Gene Tree for BRINP3 (if available)

Paralogs for BRINP3 Gene

Paralogs for BRINP3 Gene

(2) SIMAP similar genes for BRINP3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BRINP3: view

Variants for BRINP3 Gene

Sequence variations from dbSNP and Humsavar for BRINP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs17481 -- 190,190,218(-) atttg(C/G)aaaaa intron-variant
rs725106 -- 190,378,535(-) GAAAA(C/T)GAATC intron-variant
rs815332 -- 190,170,322(+) GTGAG(A/G)ACAAT intron-variant
rs815333 -- 190,169,918(+) GGTCC(C/T)ATTAT intron-variant
rs815334 -- 190,167,668(+) GAACC(A/G)TGATT intron-variant

Variation tolerance for BRINP3 Gene

Residual Variation Intolerance Score: 13.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BRINP3 Gene

HapMap Linkage Disequilibrium report
BRINP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BRINP3 Gene

Disorders for BRINP3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for BRINP3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
tongue squamous cell carcinoma
  • squamous-cell carcinoma
ulcerative colitis
  • left-sided ulcerative colitis
myocardial infarction
  • myocardial infarction, protection against
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for BRINP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BRINP3
genes like me logo Genes that share disorders with BRINP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BRINP3 Gene

Publications for BRINP3 Gene

  1. Expression of the FAM5C in tongue squamous cell carcinoma. (PMID: 19787213) Kuroiwa T. … Shibahara T. (Oncol. Rep. 2009) 3 4 67
  2. Id4 and FABP7 are preferentially expressed in cells with astrocytic features in oligodendrogliomas and oligoastrocytomas. (PMID: 16018821) Liang Y. … Gupta N. (BMC Clin Pathol 2005) 2 3
  3. Identification and characterization of novel developmentally regulated neural-specific proteins, BRINP family. (PMID: 15193423) Kawano H. … Matsuoka I. (Brain Res. Mol. Brain Res. 2004) 2 3
  4. Different contribution of BRINP3 gene in chronic periodontitis and peri-implantitis: a cross-sectional study. (PMID: 25887438) Casado P.L. … Vieira A.R. (BMC Oral Health 2015) 3
  5. Family with sequence similarity 5, member C (FAM5C) increases leukocyte adhesion molecules in vascular endothelial cells: implication in vascular inflammation. (PMID: 25251368) Sato J. … Rikitake Y. (PLoS ONE 2014) 3

Products for BRINP3 Gene

Sources for BRINP3 Gene

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