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Aliases for BRINP2 Gene

Aliases for BRINP2 Gene

  • Bone Morphogenetic Protein/Retinoic Acid Inducible Neural-Specific 2 2 3
  • Family With Sequence Similarity 5, Member B 2 3
  • DBCCR1-Like Protein 2 3 4
  • DBCCR1L2 3 4
  • FAM5B 3 4
  • Bone Morphogenic Protein/Retinoic Acid Inducible Neural-Specific 2 3
  • BMP/Retinoic Acid-Inducible Neural-Specific Protein 2 3
  • Protein FAM5B 3
  • DBCCR1-Like2 3
  • KIAA1747 4

External Ids for BRINP2 Gene

Previous HGNC Symbols for BRINP2 Gene

  • FAM5B

Summaries for BRINP2 Gene

GeneCards Summary for BRINP2 Gene

BRINP2 (Bone Morphogenetic Protein/Retinoic Acid Inducible Neural-Specific 2) is a Protein Coding gene. An important paralog of this gene is BRINP3.

UniProtKB/Swiss-Prot for BRINP2 Gene

  • Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRINP2 Gene

Genomics for BRINP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BRINP2 Gene

Start:
177,170,922 bp from pter
End:
177,282,422 bp from pter
Size:
111,501 bases
Orientation:
Plus strand

Genomic View for BRINP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BRINP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRINP2 Gene

No data available for Regulatory Elements for BRINP2 Gene

Proteins for BRINP2 Gene

  • Protein details for BRINP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0B6-BRNP2_HUMAN
    Recommended name:
    BMP/retinoic acid-inducible neural-specific protein 2
    Protein Accession:
    Q9C0B6
    Secondary Accessions:
    • O95560
    • Q6ZWC1
    • Q7LCZ9
    • Q8N360

    Protein attributes for BRINP2 Gene

    Size:
    783 amino acids
    Molecular mass:
    89005 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB21838.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for BRINP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BRINP2 Gene

Proteomics data for BRINP2 Gene at MOPED

Post-translational modifications for BRINP2 Gene

  • Ubiquitination at Lys555
  • Glycosylation at Asn185, Asn354, Asn473, Asn579, Asn626, and Asn658
  • Modification sites at PhosphoSitePlus

Other Protein References for BRINP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BRINP2 Gene

Domains for BRINP2 Gene

Protein Domains for BRINP2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9C0B6

UniProtKB/Swiss-Prot:

BRNP2_HUMAN :
  • Q9C0B6
Domain:
  • Contains 1 MACPF domain.
Family:
  • Belongs to the BRINP family.
genes like me logo Genes that share domains with BRINP2: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for BRINP2 Gene

Function for BRINP2 Gene

Molecular function for BRINP2 Gene

UniProtKB/Swiss-Prot Function: Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition.

Phenotypes for BRINP2 Gene

genes like me logo Genes that share phenotypes with BRINP2: view

Animal Model Products

CRISPR Products

miRNA for BRINP2 Gene

miRTarBase miRNAs that target BRINP2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BRINP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for BRINP2 Gene

Localization for BRINP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRINP2 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for BRINP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with BRINP2: view

No data available for Subcellular locations from COMPARTMENTS for BRINP2 Gene

Pathways for BRINP2 Gene

SuperPathways for BRINP2 Gene

No Data Available

Interacting Proteins for BRINP2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000354481%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000354481 for BRINP2 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for BRINP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007050 cell cycle arrest IEA --
GO:0045666 positive regulation of neuron differentiation IEA --
GO:0045930 negative regulation of mitotic cell cycle IEA --
GO:0071300 cellular response to retinoic acid IEA --
genes like me logo Genes that share ontologies with BRINP2: view

No data available for Pathways by source for BRINP2 Gene

Transcripts for BRINP2 Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BRINP2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BRINP2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - - - - - -
SP2:
SP3:
SP4: - -
SP5: - - - -
SP6: -
SP7: -
SP8:

Relevant External Links for BRINP2 Gene

GeneLoc Exon Structure for
BRINP2
ECgene alternative splicing isoforms for
BRINP2

Expression for BRINP2 Gene

mRNA expression in normal human tissues for BRINP2 Gene

mRNA differential expression in normal tissues according to GTEx for BRINP2 Gene

This gene is overexpressed in Brain - Cortex (9.3), Brain - Frontal Cortex (BA9) (7.3), Brain - Anterior cingulate cortex (BA24) (6.2), and Brain - Amygdala (5.7).
genes like me logo Genes that share expressions with BRINP2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for BRINP2 Gene

Orthologs for BRINP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BRINP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BRINP2 36
  • 100 (a)
OneToOne
FAM5B 35
  • 99.66 (n)
  • 99.74 (a)
cow
(Bos Taurus)
Mammalia BRINP2 36
  • 90 (a)
OneToOne
FAM5B 35
  • 90.71 (n)
  • 95.96 (a)
dog
(Canis familiaris)
Mammalia BRINP2 36
  • 96 (a)
OneToOne
FAM5B 35
  • 90.72 (n)
  • 96.17 (a)
mouse
(Mus musculus)
Mammalia Brinp2 35
  • 90.08 (n)
  • 94.76 (a)
Brinp2 36
  • 95 (a)
OneToOne
Fam5b 16
oppossum
(Monodelphis domestica)
Mammalia BRINP2 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BRINP2 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Brinp2 35
  • 90.42 (n)
  • 94.89 (a)
chicken
(Gallus gallus)
Aves BRINP2 36
  • 82 (a)
OneToOne
FAM5B 35
  • 77.94 (n)
  • 83.49 (a)
lizard
(Anolis carolinensis)
Reptilia BRINP2 36
  • 80 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii brinp2 36
  • 62 (a)
OneToOne
brinp3a 35
  • 65.8 (n)
  • 64.84 (a)
Species with no ortholog for BRINP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRINP2 Gene

ENSEMBL:
Gene Tree for BRINP2 (if available)
TreeFam:
Gene Tree for BRINP2 (if available)

Paralogs for BRINP2 Gene

Paralogs for BRINP2 Gene

Selected SIMAP similar genes for BRINP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BRINP2: view

Variants for BRINP2 Gene

Sequence variations from dbSNP and Humsavar for BRINP2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs482484 -- 177,210,481(-) GTACA(G/T)TGCTC intron-variant
rs487768 -- 177,207,077(-) AGGCC(C/T)GATGT intron-variant
rs510635 -- 177,219,272(-) ACAAC(A/G/T)GGGTG intron-variant
rs518362 -- 177,215,587(-) ctaca(A/G)caaga intron-variant
rs526814 -- 177,176,821(-) AGCTG(C/T)AATGC intron-variant

Relevant External Links for BRINP2 Gene

HapMap Linkage Disequilibrium report
BRINP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BRINP2 Gene

Disorders for BRINP2 Gene

No disorders were found for BRINP2 Gene.

No data available for UniProtKB/Swiss-Prot for BRINP2 Gene

Publications for BRINP2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Identification and characterization of novel developmentally regulated neural-specific proteins, BRINP family. (PMID: 15193423) Kawano H. … Matsuoka I. (Brain Res. Mol. Brain Res. 2004) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for BRINP2 Gene

Sources for BRINP2 Gene

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