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Aliases for BRINP2 Gene

Aliases for BRINP2 Gene

  • BMP/Retinoic Acid Inducible Neural Specific 2 2 3 5
  • Bone Morphogenetic Protein/Retinoic Acid Inducible Neural-Specific 2 2 3
  • Family With Sequence Similarity 5, Member B 2 3
  • DBCCR1-Like Protein 2 3 4
  • DBCCR1L2 3 4
  • FAM5B 3 4
  • Bone Morphogenic Protein/Retinoic Acid Inducible Neural-Specific 2 3
  • BMP/Retinoic Acid-Inducible Neural-Specific Protein 2 3
  • Protein FAM5B 3
  • DBCCR1-Like2 3
  • KIAA1747 4

External Ids for BRINP2 Gene

Previous HGNC Symbols for BRINP2 Gene

  • FAM5B

Summaries for BRINP2 Gene

GeneCards Summary for BRINP2 Gene

BRINP2 (BMP/Retinoic Acid Inducible Neural Specific 2) is a Protein Coding gene. An important paralog of this gene is BRINP3.

UniProtKB/Swiss-Prot for BRINP2 Gene

  • Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRINP2 Gene

Genomics for BRINP2 Gene

Regulatory Elements for BRINP2 Gene

Enhancers for BRINP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around BRINP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for BRINP2 Gene

Chromosome:
1
Start:
177,170,922 bp from pter
End:
177,282,422 bp from pter
Size:
111,501 bases
Orientation:
Plus strand

Genomic View for BRINP2 Gene

Genes around BRINP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRINP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRINP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRINP2 Gene

Proteins for BRINP2 Gene

  • Protein details for BRINP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0B6-BRNP2_HUMAN
    Recommended name:
    BMP/retinoic acid-inducible neural-specific protein 2
    Protein Accession:
    Q9C0B6
    Secondary Accessions:
    • O95560
    • Q6ZWC1
    • Q7LCZ9
    • Q8N360

    Protein attributes for BRINP2 Gene

    Size:
    783 amino acids
    Molecular mass:
    89005 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB21838.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for BRINP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BRINP2 Gene

Post-translational modifications for BRINP2 Gene

  • Glycosylation at Asn 185, Asn 354, Asn 473, Asn 579, Asn 626, and Asn 658
  • Modification sites at PhosphoSitePlus

Other Protein References for BRINP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BRINP2 Gene

Domains & Families for BRINP2 Gene

Protein Domains for BRINP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BRINP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9C0B6

UniProtKB/Swiss-Prot:

BRNP2_HUMAN :
  • Contains 1 MACPF domain.
  • Belongs to the BRINP family.
Domain:
  • Contains 1 MACPF domain.
Family:
  • Belongs to the BRINP family.
genes like me logo Genes that share domains with BRINP2: view

No data available for Gene Families for BRINP2 Gene

Function for BRINP2 Gene

Molecular function for BRINP2 Gene

UniProtKB/Swiss-Prot Function:
Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition.
genes like me logo Genes that share phenotypes with BRINP2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for BRINP2

CRISPR Products

miRNA for BRINP2 Gene

miRTarBase miRNAs that target BRINP2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BRINP2 Gene

Localization for BRINP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRINP2 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for BRINP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005783 endoplasmic reticulum IBA --
GO:0030425 dendrite IBA --
GO:0043025 neuronal cell body IBA --
genes like me logo Genes that share ontologies with BRINP2: view

No data available for Subcellular locations from COMPARTMENTS for BRINP2 Gene

Pathways & Interactions for BRINP2 Gene

SuperPathways for BRINP2 Gene

No Data Available

Interacting Proteins for BRINP2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000354481%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000354481 Q9C0B6-BRNP2_HUMAN for BRINP2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for BRINP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007050 cell cycle arrest IEA --
GO:0045666 positive regulation of neuron differentiation IEA,IBA --
GO:0045930 negative regulation of mitotic cell cycle IEA,IBA --
GO:0071300 cellular response to retinoic acid IEA,IBA --
genes like me logo Genes that share ontologies with BRINP2: view

No data available for Pathways by source and SIGNOR curated interactions for BRINP2 Gene

Drugs & Compounds for BRINP2 Gene

No Compound Related Data Available

Transcripts for BRINP2 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BRINP2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - - - - - -
SP2:
SP3:
SP4: - -
SP5: - - - -
SP6: -
SP7: -
SP8:

Relevant External Links for BRINP2 Gene

GeneLoc Exon Structure for
BRINP2
ECgene alternative splicing isoforms for
BRINP2

Expression for BRINP2 Gene

mRNA expression in normal human tissues for BRINP2 Gene

mRNA differential expression in normal tissues according to GTEx for BRINP2 Gene

This gene is overexpressed in Brain - Cortex (x9.3), Brain - Frontal Cortex (BA9) (x7.3), Brain - Anterior cingulate cortex (BA24) (x6.2), and Brain - Amygdala (x5.7).

NURSA nuclear receptor signaling pathways regulating expression of BRINP2 Gene:

BRINP2
genes like me logo Genes that share expression patterns with BRINP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for BRINP2 Gene

Orthologs for BRINP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BRINP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FAM5B 34
  • 90.71 (n)
  • 95.96 (a)
BRINP2 35
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM5B 34
  • 90.72 (n)
  • 96.17 (a)
BRINP2 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Brinp2 34
  • 90.08 (n)
  • 94.76 (a)
Brinp2 16
Brinp2 35
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FAM5B 34
  • 99.66 (n)
  • 99.74 (a)
BRINP2 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Brinp2 34
  • 90.42 (n)
  • 94.89 (a)
oppossum
(Monodelphis domestica)
Mammalia BRINP2 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BRINP2 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM5B 34
  • 77.94 (n)
  • 83.49 (a)
BRINP2 35
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BRINP2 35
  • 80 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii brinp3a 34
  • 65.8 (n)
  • 64.84 (a)
brinp2 35
  • 62 (a)
OneToOne
Species where no ortholog for BRINP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRINP2 Gene

ENSEMBL:
Gene Tree for BRINP2 (if available)
TreeFam:
Gene Tree for BRINP2 (if available)

Paralogs for BRINP2 Gene

Paralogs for BRINP2 Gene

(2) SIMAP similar genes for BRINP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BRINP2: view

Variants for BRINP2 Gene

Sequence variations from dbSNP and Humsavar for BRINP2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs16850984 - 177,230,088(+) GGAGT(A/G)TGCTG reference, missense
rs3176443 - 177,278,718(+) GGATC(C/G)TACGC reference, missense
rs510635 -- 177,219,272(-) ACAAC(A/G/T)GGGTG intron-variant
rs554351 -- 177,220,796(+) GGGCA(C/T)GCAAG intron-variant
rs554454 -- 177,220,850(+) AACCT(A/G)TGGTT intron-variant

Variation tolerance for BRINP2 Gene

Residual Variation Intolerance Score: 58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.93; 83.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BRINP2 Gene

Human Gene Mutation Database (HGMD)
BRINP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
BRINP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BRINP2 Gene

Disorders for BRINP2 Gene

Relevant External Links for BRINP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BRINP2

No disorders were found for BRINP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BRINP2 Gene

Publications for BRINP2 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 65
  2. Identification and characterization of novel developmentally regulated neural-specific proteins, BRINP family. (PMID: 15193423) Kawano H. … Matsuoka I. (Brain Res. Mol. Brain Res. 2004) 2 3 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 3 4 65

Products for BRINP2 Gene

Sources for BRINP2 Gene

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