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BRINP1 Gene

protein-coding   GIFtS: 39
GCID: GC09M121917

Bone Morphogenetic Protein/Retinoic Acid Inducible Neural-Specific...

(Previous names: deleted in bladder cancer chromosome region candidate 1,...)
(Previous symbols: DBCCR1, DBC1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Bone Morphogenetic Protein/Retinoic Acid Inducible Neural-Specific
11 2
     Deleted In Bladder Cancer Protein 12 3
DBC11 2 3 5     FAM5A2 3
DBCCR11 2 3 5     BA574M5.1 (Deleted In Bladder Cancer Chromosome Region Candidate 1
(IB3089A))2
Deleted In Bladder Cancer 11 2     BMP/Retinoic Acid-Inducible Neural-Specific Protein 12
Deleted In Bladder Cancer Chromosome Region Candidate 11 2     Bone Morphogenic Protein/Retinoic Acid Inducible Neural-Specific 12

External Ids:    HGNC: 26871   Entrez Gene: 16202   Ensembl: ENSG000000787257   OMIM: 6028655   UniProtKB: O604773   

Export aliases for BRINP1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BRINP1 Gene:
This gene is located within a chromosomal region that shows loss of heterozygosity in some bladder cancers. It
contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo
hypermethylation-based silencing in some bladder cancers. (provided by RefSeq, Jul 2008)

GeneCards Summary for BRINP1 Gene:
BRINP1 (bone morphogenetic protein/retinoic acid inducible neural-specific 1) is a protein-coding gene. Diseases associated with BRINP1 include breast and colorectal cancer, and transitional cell carcinoma. An important paralog of this gene is BRINP3.

UniProtKB/Swiss-Prot: BRNP1_HUMAN, O60477
Function: Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is
not of the classical apoptotic type and regulates expression of components of the plasminogen pathway

Gene Wiki entry for BRINP1 (DBC1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for BRINP1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBRINP1 promoter sequence
   Search Chromatin IP Primers for BRINP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BRINP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q32-q33   Ensembl cytogenetic band:  9q33.1   HGNC cytogenetic band: 9q32-q33

BRINP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRINP1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M121917:  view genomic region     (about GC identifiers)

Start:
121,915,736 bp from pter      End:
122,131,745 bp from pter
Size:
216,010 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BRNP1_HUMAN, O60477 (See protein sequence)
Recommended Name: BMP/retinoic acid-inducible neural-specific protein 1 precursor  
Size: 761 amino acids; 88760 Da
Miscellaneous: Silenced by methylation in 50% of bladder cancer cell lines
Secondary accessions: Q6IPV6 Q6P1A0 Q8WU22
Alternative splicing: 3 isoforms:  O60477-1   O60477-2   O60477-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BRINP1: NX_O60477

Explore proteomics data for BRINP1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn156, Asn433, Asn443, Asn553, Asn599, Asn631, Asn677
  • Modification sites at PhosphoSitePlus

  • See BRINP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055433.2  
    ENSEMBL proteins: 
     ENSP00000265922   ENSP00000363075  

    BRINP1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR020864 MACPF

    Graphical View of Domain Structure for InterPro Entry O60477

    ProtoNet protein and cluster: O60477

    UniProtKB/Swiss-Prot: BRNP1_HUMAN, O60477
    Similarity: Belongs to the BRINP family
    Similarity: Contains 1 MACPF domain


    BRINP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BRNP1_HUMAN, O60477
    Function: Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is
    not of the classical apoptotic type and regulates expression of components of the plasminogen pathway

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12442002
         
    BRINP1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BRINP1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BRINP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BRINP1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BRNP1_HUMAN, O60477: Cytoplasm

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA11420708
    GO:0015630microtubule cytoskeleton ----

    BRINP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BRINP1
    Interactions:

        Search GeneGlobe Interaction Network for BRINP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BRINP1 (O604771, 3 ENSP000002659224) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC3O153793, ENSP000003029674I2D: score=1 STRING: ENSP00000302967
    SIRT1Q96EB63, ENSP000002120154I2D: score=1 STRING: ENSP00000212015
    SMPDL3AQ924843, ENSP000003574254I2D: score=1 STRING: ENSP00000357425
    SUV39H1O434633, ENSP000003658774I2D: score=1 STRING: ENSP00000365877
    HDAC1Q135473, ENSP000003626494I2D: score=1 STRING: ENSP00000362649
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007050cell cycle arrest IEA--
    GO:0008219cell death IDA14712213
    GO:0045786negative regulation of cell cycle IDA11420708

    BRINP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BRINP1 (BRNP1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for BRINP1 gene: 
    NM_014618.2  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000482797 ENST00000265922(uc004bkc.2) ENST00000373964(uc004bkd.2)

    miRNA
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    OriGene qPCR primer pairs and template standards for BRINP1
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      QuantiTect SYBR Green Assays in human, mouse, rat BRINP1
      QuantiFast Probe-based Assays in human, mouse, rat BRINP1

    Selected AceView cDNA sequences (see all 58):

    T16063 Z41452 BI488483 BM929506 BM726737 BC071702 BU626191 AI874202 
    F08986 AA326334 CB047003 BF308764 CD625836 AF027734 T15661 BQ889616 
    BF348205 BM681521 BI489454 R42933 BG419841 BC065196 AA948693 AI753300 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BRINP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    BRINP1 Expression
    About this image


    BRINP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neurons
             Ventral/hypothalamic-like neurons
     
     Brain (Nervous System)
             Ventral/hypothalamic-like neurons
    BRINP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BRINP1 Protein Expression

    UniProtKB/Swiss-Prot: BRNP1_HUMAN, O60477
    Tissue specificity: Highly expressed in brain. Weakly expressed in heart, lung, skeletal muscle, kidney, thymus,
    prostate, testis and small intestine

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for BRINP1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dbc15
    Brinp11
    deleted in bladder cancer 1 (human)5
    bone morphogenic protein/retinoic acid inducible neural more1
    92.37(n)1
    98.82(a)1
      4 (35.03 cM)5
    567101  NM_019967.21  NP_064351.21 
     687615145 
    chicken
    (Gallus gallus)
    Aves BRINP11 deleted in bladder cancer 1 87.12(n)
    95.93(a)
      395098  NM_204449.1  NP_989780.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    87(a)
    87(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    GL343398.1(3897-64645)
    GL343450.1(18699-125581)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.326042 Xenopus laevis transcribed sequence with moderate similarity more 79.07(n)    BJ621296.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003343751 deleted in bladder cancer protein 1 homolog 77.23(n)
    85.32(a)
      100334375  XM_002662218.3  XP_002662264.3 


    ENSEMBL Gene Tree for BRINP1 (if available)
    TreeFam Gene Tree for BRINP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BRINP1 gene
    BRINP32  BRINP22  
    2 SIMAP similar genes for BRINP1 using alignment to 1 protein entry:     BRNP1_HUMAN:
    BRINP2    BRINP3

    BRINP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BRINP1 (see all 3909)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363364
    A colorectal cancer sample4--see VAR_0363362 P T mis40--------
    rs360369551,2
    C--91624689(+) CACAC-/AT/CA 
            
    ATACA
    1 -- int10--------
    rs713829511,2
    C--91733324(-) ATTGT-/AA/AAA
            
    AAAAA
    1 -- int11NA 2
    rs2022018741,2
    C--121928486(+) GACTG-/AAAAAA 1 -- ds50010--------
    rs1505784931,2
    C--121928843(+) GTGTG-/AGAA  
            
    AGAGT
    1 -- ds50010--------
    rs2301041,2
    C,F,H--121928870(-) TGTGTT/GTGTTT 1 -- ds500114Minor allele frequency- G:0.20NS NA WA CSA 1714
    rs792913861,2
    C,F--121928928(+) AAATAT/GCTTCT 1 -- ut311Minor allele frequency- G:0.05EA 120
    rs1491751151,2
    --121929185(+) CCCAAC/TGCTTT 1 -- ut310--------
    rs1465416521,2
    --121929285(+) GGTTTC/TTTTGT 1 -- ut310--------
    rs774278271,2
    C--121929357(+) GAGTCC/TCGGGT 1 -- ut311Minor allele frequency- T:0.01EA 120

    HapMap Linkage Disequilibrium report for BRINP1 (121915736 - 122131745 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for BRINP1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BRINP1
    DNA2.0 Custom Variant and Variant Library Synthesis for BRINP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602865    OMIM disorders: --

    11 diseases for BRINP1:    
    About MalaCards
    breast and colorectal cancer    transitional cell carcinoma    oral squamous cell carcinoma    astrocytoma
    multiple sclerosis    parkinson's disease    squamous cell carcinoma    colorectal cancer
    lung cancer    breast cancer    prostatitis


    BRINP1 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for BRINP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bladder cancer 72.6 13 11420708 (3), 9545632 (2), 14712213 (1), 12442002 (1) (see all 7)
    carcinoma transitional cell 65 1 11921286 (1)
    bladder tumors 63.8 5 14712213 (2), 12442002 (1), 11921286 (1)
    tumors 25.9 10 15746151 (3), 14712213 (1), 9545632 (1), 11450846 (1) (see all 8)
    cancer 0 1 15746151 (1)


    Export disorders for BRINP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BRINP1 gene, integrated from 10 sources (see all 49):
    (articles sorted by number of sources associating them with BRINP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1. (PubMed id 11420708)1, 2, 9 Nishiyama H.... Knowles M.A. (Oncogene 2001)
    2. DBCCR1 mediates death in cultured bladder tumor cells. (PubMed id 14712213)1, 2, 9 Wright K.O.... Reeder J.E. (Oncogene 2004)
    3. Structure and methylation-based silencing of a gene (DBCCR1) within a candidate bladder cancer tumor suppressor region at 9q32-q33. (PubMed id 9545632)1, 2, 9 Habuchi T.... Knowles M.A. (Genomics 1998)
    4. A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33. (PubMed id 10444335)1, 3, 9 Nishiyama H....Knowles M.A. (Genomics 1999)
    5. DBC1 re-expression alters the expression of multiple components of the plasminogen pathway. (PubMed id 16369496)1, 2 Louhelainen J.P....Knowles M.A. (Oncogene 2006)
    6. Molecular mechanisms regulating cell type specific expression of BMP/RA Inducible Neural-specific Protein-1 that suppresses cell cycle progression: roles of NRSF/REST and DNA methylation. (PubMed id 15193422)1, 3 Toshiyuki N. and Ichiro M. (Brain Res. Mol. Brain Res. 2004)
    7. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC. (PubMed id 9175739)1, 3 Habuchi T....Knowles M.A. (Hum. Mol. Genet. 1997)
    10. Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers. (PubMed id 15746151)1, 9 Izumi H....Imoto I. (Hum. Mol. Genet. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1620 HGNC: 2687 AceView: DBC1 Ensembl:ENSG00000078725 euGenes: HUgn1620
    ECgene: BRINP1 H-InvDB: BRINP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BRINP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BRINP1 gene:
    Search GeneIP for patents involving BRINP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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