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Aliases for BRINP1 Gene

Aliases for BRINP1 Gene

  • BMP/Retinoic Acid Inducible Neural Specific 1 2 3 5
  • Bone Morphogenetic Protein/Retinoic Acid Inducible Neural-Specific 1 2 3
  • Deleted In Bladder Cancer Chromosome Region Candidate 1 2 3
  • Deleted In Bladder Cancer Protein 1 3 4
  • Deleted In Bladder Cancer 1 2 3
  • DBCCR1 3 4
  • FAM5A 3 4
  • DBC1 3 4
  • BA574M5.1 (Deleted In Bladder Cancer Chromosome Region Candidate 1 (IB3089A)) 3
  • Bone Morphogenic Protein/Retinoic Acid Inducible Neural-Specific 1 3
  • BMP/Retinoic Acid-Inducible Neural-Specific Protein 1 3

External Ids for BRINP1 Gene

Previous HGNC Symbols for BRINP1 Gene

  • DBCCR1
  • DBC1

Previous GeneCards Identifiers for BRINP1 Gene

  • GC09M121917

Summaries for BRINP1 Gene

Entrez Gene Summary for BRINP1 Gene

  • This gene is located within a chromosomal region that shows loss of heterozygosity in some bladder cancers. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers. [provided by RefSeq, Jul 2008]

GeneCards Summary for BRINP1 Gene

BRINP1 (BMP/Retinoic Acid Inducible Neural Specific 1) is a Protein Coding gene. Diseases associated with BRINP1 include Transitional Cell Carcinoma and Bladder Cancer, Somatic. An important paralog of this gene is BRINP3.

UniProtKB/Swiss-Prot for BRINP1 Gene

  • Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway.

Gene Wiki entry for BRINP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRINP1 Gene

Genomics for BRINP1 Gene

Regulatory Elements for BRINP1 Gene

Enhancers for BRINP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around BRINP1 on UCSC Golden Path with GeneCards custom track

Promoters for BRINP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BRINP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for BRINP1 Gene

Chromosome:
9
Start:
119,153,458 bp from pter
End:
119,369,467 bp from pter
Size:
216,010 bases
Orientation:
Minus strand

Genomic View for BRINP1 Gene

Genes around BRINP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRINP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRINP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRINP1 Gene

Proteins for BRINP1 Gene

  • Protein details for BRINP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60477-BRNP1_HUMAN
    Recommended name:
    BMP/retinoic acid-inducible neural-specific protein 1
    Protein Accession:
    O60477
    Secondary Accessions:
    • Q6IPV6
    • Q6P1A0
    • Q8WU22

    Protein attributes for BRINP1 Gene

    Size:
    761 amino acids
    Molecular mass:
    88760 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Silenced by methylation in 50% of bladder cancer cell lines.

    Alternative splice isoforms for BRINP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BRINP1 Gene

Post-translational modifications for BRINP1 Gene

  • Glycosylation at Asn 156, Asn 433, Asn 443, Asn 553, Asn 599, Asn 631, and Asn 677
  • Modification sites at PhosphoSitePlus

Other Protein References for BRINP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BRINP1 Gene

Domains & Families for BRINP1 Gene

Protein Domains for BRINP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BRINP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60477

UniProtKB/Swiss-Prot:

BRNP1_HUMAN :
  • Contains 1 MACPF domain.
  • Belongs to the BRINP family.
Domain:
  • Contains 1 MACPF domain.
Family:
  • Belongs to the BRINP family.
genes like me logo Genes that share domains with BRINP1: view

No data available for Gene Families for BRINP1 Gene

Function for BRINP1 Gene

Molecular function for BRINP1 Gene

UniProtKB/Swiss-Prot Function:
Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway.

Gene Ontology (GO) - Molecular Function for BRINP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12442002
genes like me logo Genes that share ontologies with BRINP1: view
genes like me logo Genes that share phenotypes with BRINP1: view

Animal Models for BRINP1 Gene

MGI Knock Outs for BRINP1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for BRINP1 Gene

Localization for BRINP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRINP1 Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for BRINP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11420708
GO:0005783 endoplasmic reticulum IBA --
GO:0030425 dendrite IBA --
GO:0043025 neuronal cell body IBA --
genes like me logo Genes that share ontologies with BRINP1: view

No data available for Subcellular locations from COMPARTMENTS for BRINP1 Gene

Pathways & Interactions for BRINP1 Gene

SuperPathways for BRINP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BRINP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007050 cell cycle arrest IEA --
GO:0008219 cell death IDA 14712213
GO:0035176 social behavior IEA --
GO:0045666 positive regulation of neuron differentiation IEA,IBA --
GO:0045786 negative regulation of cell cycle IDA 11420708
genes like me logo Genes that share ontologies with BRINP1: view

No data available for Pathways by source and SIGNOR curated interactions for BRINP1 Gene

Drugs & Compounds for BRINP1 Gene

No Compound Related Data Available

Transcripts for BRINP1 Gene

mRNA/cDNA for BRINP1 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BRINP1 Gene

No ASD Table

Relevant External Links for BRINP1 Gene

GeneLoc Exon Structure for
BRINP1
ECgene alternative splicing isoforms for
BRINP1

Expression for BRINP1 Gene

mRNA expression in normal human tissues for BRINP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BRINP1 Gene

This gene is overexpressed in Brain - Cortex (x6.1), Brain - Frontal Cortex (BA9) (x5.7), Brain - Anterior cingulate cortex (BA24) (x4.3), Brain - Hippocampus (x4.3), Brain - Putamen (basal ganglia) (x4.2), Brain - Cerebellar Hemisphere (x4.1), and Brain - Nucleus accumbens (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for BRINP1 Gene

This gene is overexpressed in Bone marrow stromal cell (56.8) and Stomach (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BRINP1 Gene



Protein tissue co-expression partners for BRINP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of BRINP1 Gene:

BRINP1

mRNA Expression by UniProt/SwissProt for BRINP1 Gene:

O60477-BRNP1_HUMAN
Tissue specificity: Highly expressed in brain. Weakly expressed in heart, lung, skeletal muscle, kidney, thymus, prostate, testis and small intestine.
genes like me logo Genes that share expression patterns with BRINP1: view

Primer Products

Orthologs for BRINP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BRINP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BRINP1 34
  • 93.82 (n)
  • 98.82 (a)
BRINP1 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BRINP1 34
  • 94.35 (n)
  • 99.34 (a)
BRINP1 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Brinp1 34
  • 92.37 (n)
  • 98.82 (a)
Brinp1 16
Brinp1 35
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DBC1 34
  • 99.39 (n)
  • 100 (a)
DBC1 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Brinp1 34
  • 92.15 (n)
  • 98.68 (a)
oppossum
(Monodelphis domestica)
Mammalia BRINP1 35
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BRINP1 35
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves BRINP1 34
  • 87.12 (n)
  • 95.93 (a)
BRINP1 35
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 86 (a)
OneToMany
-- 35
  • 87 (a)
OneToMany
-- 35
  • 87 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia dbc1 34
  • 76 (n)
  • 84.94 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32604 34
zebrafish
(Danio rerio)
Actinopterygii LOC100334375 34
  • 77.23 (n)
  • 85.32 (a)
BRINP1 35
  • 84 (a)
OneToOne
Species where no ortholog for BRINP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRINP1 Gene

ENSEMBL:
Gene Tree for BRINP1 (if available)
TreeFam:
Gene Tree for BRINP1 (if available)

Paralogs for BRINP1 Gene

Paralogs for BRINP1 Gene

(2) SIMAP similar genes for BRINP1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with BRINP1: view

Variants for BRINP1 Gene

Sequence variations from dbSNP and Humsavar for BRINP1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1043377 - 119,168,061(-) GCTGC(A/G)CCATG reference, missense
VAR_029989 -
rs17476783 - 119,208,791(+) CAGTG(A/C/T)GTTGG reference, missense
VAR_036336 A colorectal cancer sample
rs17526 -- 119,272,795(-) AGTAC(A/G)GGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BRINP1 Gene

Variant ID Type Subtype PubMed ID
esv2664120 CNV deletion 23128226
esv275135 CNV loss 21479260
esv5965 CNV gain 19470904
nsv1110579 CNV duplication 24896259
nsv1144291 CNV deletion 24896259
nsv1150761 CNV insertion 26484159
nsv527574 CNV loss 19592680
nsv7434 OTHER inversion 18451855
nsv831708 CNV loss 17160897

Variation tolerance for BRINP1 Gene

Residual Variation Intolerance Score: 14.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.81; 66.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BRINP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BRINP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRINP1 Gene

Disorders for BRINP1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for BRINP1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
transitional cell carcinoma
  • transitional carcinoma
bladder cancer, somatic
  • bladder carcinoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for BRINP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BRINP1
genes like me logo Genes that share disorders with BRINP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BRINP1 Gene

Publications for BRINP1 Gene

  1. DBCCR1 mediates death in cultured bladder tumor cells. (PMID: 14712213) Wright K.O. … Reeder J.E. (Oncogene 2004) 3 4 22 65
  2. Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1. (PMID: 11420708) Nishiyama H. … Knowles M.A. (Oncogene 2001) 3 4 22 65
  3. A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33. (PMID: 10444335) Nishiyama H. … Knowles M.A. (Genomics 1999) 2 3 22 65
  4. Structure and methylation-based silencing of a gene (DBCCR1) within a candidate bladder cancer tumor suppressor region at 9q32-q33. (PMID: 9545632) Habuchi T. … Knowles M.A. (Genomics 1998) 3 4 22 65
  5. DBC1 re-expression alters the expression of multiple components of the plasminogen pathway. (PMID: 16369496) Louhelainen J.P. … Knowles M.A. (Oncogene 2006) 3 4 65

Products for BRINP1 Gene

Sources for BRINP1 Gene

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