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Aliases for BRICD5 Gene

Aliases for BRICD5 Gene

  • BRICHOS Domain Containing 5 2 3 5
  • C16orf79 3 4
  • BRICHOS Domain-Containing Protein C16orf79 3
  • Chromosome 16 Open Reading Frame 79 2
  • BRICHOS Domain-Containing Protein 5 3

External Ids for BRICD5 Gene

Previous HGNC Symbols for BRICD5 Gene

  • C16orf79

Previous GeneCards Identifiers for BRICD5 Gene

  • GC16M002260
  • GC16M002262
  • GC16M002263
  • GC16M002223
  • GC16M002226

Summaries for BRICD5 Gene

GeneCards Summary for BRICD5 Gene

BRICD5 (BRICHOS Domain Containing 5) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRICD5 Gene

Genomics for BRICD5 Gene

Regulatory Elements for BRICD5 Gene

Enhancers for BRICD5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F002230 1.2 Ensembl ENCODE 17.5 -22.5 -22522 11.1 ZNF76 KLF17 SIN3A FEZF1 RAD21 GLIS2 KLF7 EGR2 SP3 MIER2 ENSG00000261505 BRICD5 ENSG00000260051 ENSG00000260954 THOC6 ENSG00000255513 SNORA64 LOC105371055 SNORD60 MLST8
GH16F002211 1.1 ENCODE 18.7 -0.8 -781 5.1 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 PGP BRICD5 ZNF213-AS1 NME3 EME2 IFT140 MIR940 HN1L SNHG19 ENSG00000260051
GH16F002210 0.8 ENCODE 18.7 +2.6 2638 1.0 TBP PKNOX1 CBX3 SAP130 ARID4B THRB RARA GLIS2 POLR2A NCOR1 BRICD5 ZNF213-AS1 ENSG00000261532 PIR40952
GH16F002032 1.3 Ensembl ENCODE 7 +175.0 174978 12.9 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 FOS IFT140 PKD1 HN1L NME3 FLYWCH2 RAB26 SNORD60 TRAF7 MIR6511B1 SYNGR3
GH16F001956 0.5 FANTOM5 17.3 +256.7 256650 0.1 GLIS2 GLIS1 PATZ1 ZIC2 RNF151 ENSG00000255513 BRICD5 PRSS30P RPL3L MSRB1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BRICD5 on UCSC Golden Path with GeneCards custom track

Genomic Location for BRICD5 Gene

Chromosome:
16
Start:
2,209,253 bp from pter
End:
2,213,540 bp from pter
Size:
4,288 bases
Orientation:
Minus strand

Genomic View for BRICD5 Gene

Genes around BRICD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRICD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRICD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRICD5 Gene

Proteins for BRICD5 Gene

  • Protein details for BRICD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PL45-BRID5_HUMAN
    Recommended name:
    BRICHOS domain-containing protein 5
    Protein Accession:
    Q6PL45
    Secondary Accessions:
    • C9J7K2
    • Q8IXU9

    Protein attributes for BRICD5 Gene

    Size:
    260 amino acids
    Molecular mass:
    28486 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BRICD5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BRICD5 Gene

Post-translational modifications for BRICD5 Gene

  • Glycosylation at Asn 79
  • Modification sites at PhosphoSitePlus

Other Protein References for BRICD5 Gene

No data available for DME Specific Peptides for BRICD5 Gene

Domains & Families for BRICD5 Gene

Gene Families for BRICD5 Gene

Protein Domains for BRICD5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for BRICD5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PL45

UniProtKB/Swiss-Prot:

BRID5_HUMAN :
  • Contains 1 BRICHOS domain.
Domain:
  • Contains 1 BRICHOS domain.
genes like me logo Genes that share domains with BRICD5: view

Function for BRICD5 Gene

Gene Ontology (GO) - Molecular Function for BRICD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with BRICD5: view
genes like me logo Genes that share phenotypes with BRICD5: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for BRICD5 Gene

Localization for BRICD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRICD5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BRICD5 gene
Compartment Confidence
plasma membrane 3
extracellular 3

Gene Ontology (GO) - Cellular Components for BRICD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BRICD5: view

Pathways & Interactions for BRICD5 Gene

SuperPathways for BRICD5 Gene

No Data Available

Interacting Proteins for BRICD5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000332389%0d%0a9606.ENSP00000316130%0d%0a
Selected Interacting proteins: ENSP00000332389 Q6PL45-BRID5_HUMAN for BRICD5 Gene via STRING UniProtKB IID

Gene Ontology (GO) - Biological Process for BRICD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042127 regulation of cell proliferation IBA --
genes like me logo Genes that share ontologies with BRICD5: view

No data available for Pathways by source and SIGNOR curated interactions for BRICD5 Gene

Transcripts for BRICD5 Gene

mRNA/cDNA for BRICD5 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BRICD5 Gene

BRICHOS domain containing 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BRICD5 Gene

No ASD Table

Relevant External Links for BRICD5 Gene

GeneLoc Exon Structure for
BRICD5
ECgene alternative splicing isoforms for
BRICD5

Expression for BRICD5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BRICD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BRICD5 Gene

This gene is overexpressed in Brain - Cerebellum (x6.9) and Brain - Cerebellar Hemisphere (x6.1).

NURSA nuclear receptor signaling pathways regulating expression of BRICD5 Gene:

BRICD5

SOURCE GeneReport for Unigene cluster for BRICD5 Gene:

Hs.647399
genes like me logo Genes that share expression patterns with BRICD5: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for BRICD5 Gene

Orthologs for BRICD5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BRICD5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BRICD5 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bricd5 34 16 35
  • 79.41 (n)
cow
(Bos Taurus)
Mammalia BRICD5 34 35
  • 78.15 (n)
dog
(Canis familiaris)
Mammalia BRICD5 34 35
  • 76.74 (n)
oppossum
(Monodelphis domestica)
Mammalia BRICD5 35
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves BRICD5 35
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BRICD5 35
  • 35 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bricd5 34
  • 54.89 (n)
zebrafish
(Danio rerio)
Actinopterygii bricd5 34 35
  • 53.92 (n)
Species where no ortholog for BRICD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRICD5 Gene

ENSEMBL:
Gene Tree for BRICD5 (if available)
TreeFam:
Gene Tree for BRICD5 (if available)

Paralogs for BRICD5 Gene

No data available for Paralogs for BRICD5 Gene

Variants for BRICD5 Gene

Sequence variations from dbSNP and Humsavar for BRICD5 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1046703 -- 2,209,194(+) GCGTT(C/T)TCTGC intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs111273330 -- 2,212,271(+) GCCTG(G/T)GAGGT nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime, utr-variant-5-prime
rs111384111 -- 2,209,409(+) GCTCG(A/G)GAAGC nc-transcript-variant, reference, missense, utr-variant-3-prime
rs111487907 -- 2,212,424(+) TGGCC(C/G)TGCTG nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime, utr-variant-5-prime
rs111783594 -- 2,209,040(+) TCTCA(G/T)CCCCC intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for BRICD5 Gene

Variant ID Type Subtype PubMed ID
nsv952902 CNV deletion 24416366
nsv571200 CNV loss 21841781
nsv471072 CNV loss 18288195
nsv457351 CNV loss 19166990
nsv1711 CNV insertion 18451855
nsv1052260 CNV gain 25217958
esv2422427 CNV duplication 17116639
dgv4863n54 CNV loss 21841781
dgv4861n54 CNV loss 21841781
dgv4859n54 CNV loss 21841781

Variation tolerance for BRICD5 Gene

Residual Variation Intolerance Score: 92.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.42; 54.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BRICD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BRICD5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRICD5 Gene

Disorders for BRICD5 Gene

Relevant External Links for BRICD5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BRICD5

No disorders were found for BRICD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BRICD5 Gene

Publications for BRICD5 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 4 64

Products for BRICD5 Gene

Sources for BRICD5 Gene

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