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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BRICD5 Gene

protein-coding   GIFtS: 34
GCID: GC16M002262

BRICHOS Domain Containing 5

(Previous name: chromosome 16 open reading frame 79)
(Previous symbol: C16orf79)
  Search for BRICD5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
BRICHOS Domain Containing 51 2
C16orf791 2 3
Chromosome 16 Open Reading Frame 791 2
BRICHOS Domain-Containing Protein 52
BRICHOS Domain-Containing Protein C16orf792

External Ids:    HGNC: 283091   Entrez Gene: 2838702   Ensembl: ENSG000001826857   UniProtKB: Q6PL453   

Export aliases for BRICD5 gene to outside databases

Previous GC identifer: GC16M002260


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for BRICD5 Gene: 
BRICD5 (BRICHOS domain containing 5) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for BRICD5
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for BRICD5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BRICD5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

BRICD5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRICD5 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M002262:  view genomic region     (about GC identifiers)

Start:
2,259,254 bp from pter      End:
2,261,951 bp from pter
Size:
2,698 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BRID5_HUMAN, Q6PL45 (See protein sequence)
Recommended Name: BRICHOS domain-containing protein 5  
Size: 260 amino acids; 28486 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: C9J7K2 Q8IXU9
Alternative splicing: 2 isoforms:  Q6PL45-1   Q6PL45-2   

Explore the universe of human proteins at neXtProt for BRICD5: NX_Q6PL45

Explore proteomics data for BRICD5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6PL45

  • BRICD5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BRICD5 Protein Expression
    REFSEQ proteins: NP_872369.2  
    ENSEMBL proteins: 
     ENSP00000332389   ENSP00000455052   ENSP00000457969  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    BRICD5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BRICD: BRICHOS domain containing

    1 InterPro protein domain:
     IPR007084 BRICHOS_dom

    Graphical View of Domain Structure for InterPro Entry Q6PL45

    ProtoNet protein and cluster: Q6PL45

    1 Blocks protein domain: IPB007084 BRICHOS domain

    UniProtKB/Swiss-Prot: BRID5_HUMAN, Q6PL45
    Similarity: Contains 1 BRICHOS domain


    BRICD5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         2 GenomeRNAi human phenotypes for BRICD5:
     Increased HPV18 LCR reporter a  Proliferating cells 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for BRICD5 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BRICD5

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BRICD5 (BRID5)

    Search CenterWatch for drugs/clinical trials and news about BRICD5 / BRID5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BRICD5 gene: 
    NM_182563.3  

    Unigene Cluster for BRICD5:

    BRICHOS domain containing 5
    Hs.647399  [show with all ESTs]
    Unigene Representative Sequence: BM548657
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328540(uc002cpi.2 uc010bsh.3) ENST00000562360 ENST00000566795
    ENST00000566018
    miRNA
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    Additional mRNA sequence: BC039154.2 

    6 DOTS entries:

    DT.447261  DT.100842882  DT.455001  DT.70103990  DT.91945744  DT.95268700 

    5 AceView cDNA sequences:

    AY597811 BC039154 NM_182563 BF848006 BF822645 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    BRICD5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...
     
     Brain (Nervous System)
             cerebellum   

    See BRICD5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BRICD5

    SOURCE GeneReport for Unigene cluster: Hs.647399
        SABiosciences Custom PCR Arrays for BRICD5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRICD5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for BRICD5 gene from 4/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bricd51 , 5 RIKEN cDNA 9930021D14 gene5
    BRICHOS domain containing 51
    79.41(n)1
    72.94(a)1
      17 (12.39 cM)5
    3192591  NM_175682.31  NP_783613.11 
     244738845 
    chicken
    (Gallus gallus)
    Aves C16ORF796
    Uncharacterized protein
    43(a)
    1 ↔ 1
    14(6480871-6483227)
    lizard
    (Anolis carolinensis)
    Reptilia BRICD56
    BRICHOS domain containing 5
    35(a)
    1 ↔ 1
    GL343827.1(29647-37995)
    zebrafish
    (Danio rerio)
    Actinopterygii im:71382631 im:7138263 51.5(n)
    40.76(a)
      792755  XM_001332216.2  XP_001332252.1 


    ENSEMBL Gene Tree for BRICD5 (if available)
    TreeFam Gene Tree for BRICD5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/102 SNPs in BRICD5 are shown (see all 102)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1997172221,2
    --2259925(+) GCCCGG/TGCCTG 1 -- int10--------
    rs2012807721,2
    C--2259932(+) CCTGCG/TCCCAG 1 -- int10--------
    rs1409563331,2
    C,F--2259955(+) CCTTGG/AAGGTA 2 /S /F mis11Minor allele frequency- A:0.00NA 3834
    rs1498196311,2
    C,F--2259986(+) CTCCCG/AATCAC 2 /R /W mis12Minor allele frequency- A:0.00NA EU 5027
    rs1458778301,2
    C,F--2260024(+) CCTGGT/GGCTCC 2 /H /P mis12Minor allele frequency- G:0.00NA EU 4735
    rs582923511,2,4
    C,F--2260025(+) CTGGTG/ACTCCT 2 /H /Y mis14Minor allele frequency- A:0.02WA NA EU 4851
    rs2009267671,2
    --2260104(+) CCAGGA/GTGACC 1 -- int10--------
    rs1839585401,2
    --2260115(+) CCTCCC/TTGCCC 1 -- int10--------
    rs1997756691,2
    C--2260126(+) ACTCAC/G/TGCTCT 1 -- spd10--------
    rs2000625031,2
    --2260191(+) TGGTCA/GCCGCG 2 A V mis10--------

    HapMap Linkage Disequilibrium report for BRICD5 (2259254 - 2261951 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for BRICD5: --
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for BRICD5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BRICD5 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with BRICD5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    2. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    3. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 283870 HGNC: 28309 AceView: MGC21830 Ensembl:ENSG00000182685 euGenes: HUgn283870
    ECgene: BRICD5 H-InvDB: BRICD5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BRICD5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BRICD5 gene:
    Search GeneIP for patents involving BRICD5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     Custom Antibody / Protein Production Service
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     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for BRICD5
     Gene Synthesis
     Protein Engineering
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     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRICD5
     Browse SwitchGear 3'UTR luciferase reporter plasmids for BRICD5
     Browse SwitchGear Promoter luciferase reporter plasmids for BRICD5
     Search ThermoFisher Antibodies for BRICD5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRICD5
     inGenious Targeting Laboratory - Custom generated mouse model solutions for BRICD5
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BRICD5
    Customized:
     lentivirus for stable overexpression of BRICD5
     lentivirus expression plasmids for stable overexpression of BRICD5
     adenovirus for overexpression of BRICD5
     Search LSBio for Antibodies for BRICD5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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