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Aliases for BRI3BP Gene

Aliases for BRI3BP Gene

  • BRI3 Binding Protein 2 3 5
  • Cervical Cancer 1 Proto-Oncogene-Binding Protein KG19 3 4
  • I3-Binding Protein 3 4
  • HCCRBP-1 3 4
  • KG19 3 4
  • Cervical Cancer Oncogene Binding Protein 3
  • BRI3-Binding Protein 3
  • HCCRBP-3 3
  • HCCR-1 3
  • HCCR-2 3
  • BNAS1 3

External Ids for BRI3BP Gene

Previous GeneCards Identifiers for BRI3BP Gene

  • GC12P124206
  • GC12P125244
  • GC12P123831
  • GC12P124003
  • GC12P125478
  • GC12P122461

Summaries for BRI3BP Gene

GeneCards Summary for BRI3BP Gene

BRI3BP (BRI3 Binding Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for BRI3BP Gene

  • Involved in tumorigenesis and may function by stabilizing p53/TP53.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRI3BP Gene

Genomics for BRI3BP Gene

Regulatory Elements for BRI3BP Gene

Enhancers for BRI3BP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G124937 2.1 FANTOM5 Ensembl ENCODE dbSUPER 12.5 -54.1 -54131 5.0 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 DHX37 UBC BRI3BP NCOR2 TRD-GTC2-10 RPL22P19
GH12G124913 2.2 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -74.5 -74466 12.7 MLX CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 NCOR2 DHX37 DNAH10OS ENSG00000275389 ENSG00000270130 ENSG00000269938 ENSG00000270061 ENSG00000269997 SCARB1 BRI3BP
GH12G124992 1.3 Ensembl ENCODE 0.7 +1.4 1385 5.2 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 BRI3BP PIR45759
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BRI3BP on UCSC Golden Path with GeneCards custom track

Promoters for BRI3BP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000059016 352 2001 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 DEK ZHX2

Genomic Location for BRI3BP Gene

Chromosome:
12
Start:
124,993,648 bp from pter
End:
125,051,845 bp from pter
Size:
58,198 bases
Orientation:
Plus strand

Genomic View for BRI3BP Gene

Genes around BRI3BP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRI3BP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRI3BP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRI3BP Gene

Proteins for BRI3BP Gene

  • Protein details for BRI3BP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WY22-BRI3B_HUMAN
    Recommended name:
    BRI3-binding protein
    Protein Accession:
    Q8WY22
    Secondary Accessions:
    • Q8WY23

    Protein attributes for BRI3BP Gene

    Size:
    251 amino acids
    Molecular mass:
    27836 Da
    Quaternary structure:
    • Interacts with LETMD1.
    SequenceCaution:
    • Sequence=AAL33003.2; Type=Frameshift; Positions=43, 47, 59; Evidence={ECO:0000305};

neXtProt entry for BRI3BP Gene

Post-translational modifications for BRI3BP Gene

  • Ubiquitination at posLast=7171
  • Modification sites at PhosphoSitePlus

Other Protein References for BRI3BP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BRI3BP Gene

Domains & Families for BRI3BP Gene

Protein Domains for BRI3BP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BRI3BP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BRI3BP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for BRI3BP Gene

Function for BRI3BP Gene

Molecular function for BRI3BP Gene

UniProtKB/Swiss-Prot Function:
Involved in tumorigenesis and may function by stabilizing p53/TP53.

Phenotypes for BRI3BP Gene

GenomeRNAi human phenotypes for BRI3BP:
genes like me logo Genes that share phenotypes with BRI3BP: view

Animal Model Products

  • Taconic Biosciences Mouse Models for BRI3BP

CRISPR Products

miRNA for BRI3BP Gene

miRTarBase miRNAs that target BRI3BP

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BRI3BP Gene

Localization for BRI3BP Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRI3BP Gene

Mitochondrion outer membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BRI3BP gene
Compartment Confidence
mitochondrion 5
plasma membrane 3
extracellular 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for BRI3BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 17943721
GO:0005741 mitochondrial outer membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BRI3BP: view

Pathways & Interactions for BRI3BP Gene

SuperPathways for BRI3BP Gene

No Data Available

Interacting Proteins for BRI3BP Gene

Gene Ontology (GO) - Biological Process for BRI3BP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BRI3BP Gene

Drugs & Compounds for BRI3BP Gene

No Compound Related Data Available

Transcripts for BRI3BP Gene

mRNA/cDNA for BRI3BP Gene

Unigene Clusters for BRI3BP Gene

BRI3 binding protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for BRI3BP Gene

No ASD Table

Relevant External Links for BRI3BP Gene

GeneLoc Exon Structure for
BRI3BP
ECgene alternative splicing isoforms for
BRI3BP

Expression for BRI3BP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for BRI3BP Gene

Protein differential expression in normal tissues from HIPED for BRI3BP Gene

This gene is overexpressed in Nasal epithelium (19.7) and Heart (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BRI3BP Gene



Protein tissue co-expression partners for BRI3BP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BRI3BP Gene:

BRI3BP

SOURCE GeneReport for Unigene cluster for BRI3BP Gene:

Hs.596464

mRNA Expression by UniProt/SwissProt for BRI3BP Gene:

Q8WY22-BRI3B_HUMAN
Tissue specificity: Most abundantly expressed in brain, liver and kidney. Overexpressed in leukemia and lymphoma cell lines, as well as in various carcinomas.

Evidence on tissue expression from TISSUES for BRI3BP Gene

  • Nervous system(2.3)
  • Intestine(2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with BRI3BP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for BRI3BP Gene

Orthologs for BRI3BP Gene

This gene was present in the common ancestor of chordates.

Orthologs for BRI3BP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BRI3BP 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BRI3BP 35 34
  • 88.71 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Bri3bp 16 35 34
  • 83.54 (n)
dog
(Canis familiaris)
Mammalia BRI3BP 35
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bri3bp 34
  • 81.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia BRI3BP 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves BRI3BP 35 34
  • 75.21 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BRI3BP 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bri3bp 34
  • 68.14 (n)
Str.11937 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.19125 34
zebrafish
(Danio rerio)
Actinopterygii bri3bp 34 35
  • 68.47 (n)
Species where no ortholog for BRI3BP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRI3BP Gene

ENSEMBL:
Gene Tree for BRI3BP (if available)
TreeFam:
Gene Tree for BRI3BP (if available)

Paralogs for BRI3BP Gene

Pseudogenes.org Pseudogenes for BRI3BP Gene

genes like me logo Genes that share paralogs with BRI3BP: view

No data available for Paralogs for BRI3BP Gene

Variants for BRI3BP Gene

Sequence variations from dbSNP and Humsavar for BRI3BP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000001580 -- 124,997,984(+) CCAGG(C/T)GTGGT intron-variant
rs1000024313 -- 125,009,123(+) CAGGC(A/G)CACAA intron-variant
rs1000057568 -- 125,032,937(+) TCCTC(A/G)GACCT intron-variant
rs1000107563 -- 125,017,958(+) TTACC(C/T)TATCA intron-variant
rs1000108634 -- 125,003,311(+) AGAGC(A/G)CTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BRI3BP Gene

Variant ID Type Subtype PubMed ID
dgv325e199 CNV deletion 23128226
esv3333171 CNV duplication 20981092
esv3631032 CNV gain 21293372
esv3892269 CNV gain 25118596
esv998178 CNV insertion 20482838
nsv1047470 CNV loss 25217958
nsv1051020 CNV gain 25217958
nsv1070561 CNV deletion 25765185
nsv1126329 CNV deletion 24896259
nsv1138181 CNV deletion 24896259
nsv509485 CNV insertion 20534489
nsv560595 CNV gain 21841781

Variation tolerance for BRI3BP Gene

Residual Variation Intolerance Score: 46.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.78; 16.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BRI3BP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BRI3BP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRI3BP Gene

Disorders for BRI3BP Gene

Relevant External Links for BRI3BP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BRI3BP

No disorders were found for BRI3BP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BRI3BP Gene

Publications for BRI3BP Gene

  1. Cloning, tissue expression pattern, and chromosome location of a novel human gene BRI3BP. (PMID: 11860200) Lin L. … Zhao S. (Biochem. Genet. 2001) 2 3 4 22 64
  2. Augmentation of drug-induced cell death by ER protein BRI3BP. (PMID: 17765869) Yamazaki T. … Takeshima H. (Biochem. Biophys. Res. Commun. 2007) 2 3 22 64
  3. HCCRBP-1 directly interacting with HCCR-1 induces tumorigenesis through P53 stabilization. (PMID: 17943721) Ha S.A. … Kim J.W. (Int. J. Cancer 2008) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for BRI3BP Gene

Sources for BRI3BP Gene

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