Free for academic non-profit institutions. Other users need a Commercial license

Aliases for BRI3BP Gene

Aliases for BRI3BP Gene

  • BRI3 Binding Protein 2 3
  • Cervical Cancer 1 Proto-Oncogene-Binding Protein KG19 3 4
  • I3-Binding Protein 3 4
  • HCCRBP-1 3 4
  • KG19 3 4
  • Cervical Cancer Oncogene Binding Protein 3
  • BRI3-Binding Protein 3
  • HCCR-1 3
  • HCCR-2 3
  • BNAS1 3

External Ids for BRI3BP Gene

Previous GeneCards Identifiers for BRI3BP Gene

  • GC12P124206
  • GC12P125244
  • GC12P123831
  • GC12P124003
  • GC12P125478
  • GC12P122461

Summaries for BRI3BP Gene

GeneCards Summary for BRI3BP Gene

BRI3BP (BRI3 Binding Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for BRI3BP Gene

  • Involved in tumorigenesis and may function by stabilizing p53/TP53.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRI3BP Gene

Genomics for BRI3BP Gene

Regulatory Elements for BRI3BP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BRI3BP Gene

124,993,648 bp from pter
125,031,231 bp from pter
37,584 bases
Plus strand

Genomic View for BRI3BP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BRI3BP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRI3BP Gene

Proteins for BRI3BP Gene

  • Protein details for BRI3BP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BRI3-binding protein
    Protein Accession:
    Secondary Accessions:
    • Q8WY23

    Protein attributes for BRI3BP Gene

    251 amino acids
    Molecular mass:
    27836 Da
    Quaternary structure:
    • Interacts with LETMD1.
    • Sequence=AAL33003.2; Type=Frameshift; Positions=43, 47, 59; Evidence={ECO:0000305};

neXtProt entry for BRI3BP Gene

Proteomics data for BRI3BP Gene at MOPED

Post-translational modifications for BRI3BP Gene

  • Ubiquitination at Lys71
  • Modification sites at PhosphoSitePlus

Other Protein References for BRI3BP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BRI3BP Gene

Domains for BRI3BP Gene

Protein Domains for BRI3BP Gene


Suggested Antigen Peptide Sequences for BRI3BP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with BRI3BP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for BRI3BP Gene

Function for BRI3BP Gene

Molecular function for BRI3BP Gene

UniProtKB/Swiss-Prot Function: Involved in tumorigenesis and may function by stabilizing p53/TP53.

Animal Model Products

CRISPR Products

miRNA for BRI3BP Gene

miRTarBase miRNAs that target BRI3BP

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BRI3BP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for BRI3BP Gene

Localization for BRI3BP Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRI3BP Gene

Mitochondrion outer membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for BRI3BP Gene COMPARTMENTS Subcellular localization image for BRI3BP gene
Compartment Confidence
mitochondrion 5
plasma membrane 3
extracellular 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for BRI3BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 17943721
GO:0005741 mitochondrial outer membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BRI3BP: view

Pathways for BRI3BP Gene

SuperPathways for BRI3BP Gene

No Data Available

Interacting Proteins for BRI3BP Gene

Gene Ontology (GO) - Biological Process for BRI3BP Gene


No data available for Pathways by source for BRI3BP Gene

Transcripts for BRI3BP Gene

mRNA/cDNA for BRI3BP Gene

Unigene Clusters for BRI3BP Gene

BRI3 binding protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BRI3BP

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for BRI3BP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BRI3BP Gene

No ASD Table

Relevant External Links for BRI3BP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BRI3BP Gene

mRNA expression in normal human tissues for BRI3BP Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BRI3BP Gene

SOURCE GeneReport for Unigene cluster for BRI3BP Gene Hs.596464

mRNA Expression by UniProt/SwissProt for BRI3BP Gene

Tissue specificity: Most abundantly expressed in brain, liver and kidney. Overexpressed in leukemia and lymphoma cell lines, as well as in various carcinomas.
genes like me logo Genes that share expressions with BRI3BP: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for BRI3BP Gene

Orthologs for BRI3BP Gene

This gene was present in the common ancestor of chordates.

Orthologs for BRI3BP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BRI3BP 36
  • 100 (a)
(Bos Taurus)
Mammalia BRI3BP 35
  • 88.71 (n)
  • 89.26 (a)
  • 84 (a)
(Canis familiaris)
Mammalia BRI3BP 36
  • 82 (a)
(Mus musculus)
Mammalia Bri3bp 35
  • 83.54 (n)
  • 82.19 (a)
Bri3bp 16
Bri3bp 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia BRI3BP 36
  • 66 (a)
(Rattus norvegicus)
Mammalia Bri3bp 35
  • 81.65 (n)
  • 80.97 (a)
(Gallus gallus)
Aves BRI3BP 35
  • 75.21 (n)
  • 66.5 (a)
  • 67 (a)
(Anolis carolinensis)
Reptilia BRI3BP 36
  • 69 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19125 35
tropical clawed frog
(Silurana tropicalis)
Amphibia bri3bp 35
  • 68.14 (n)
  • 64.53 (a)
Str.11937 35
(Danio rerio)
Actinopterygii bri3bp 35
  • 68.47 (n)
  • 61.58 (a)
bri3bp 36
  • 56 (a)
Species with no ortholog for BRI3BP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRI3BP Gene

Gene Tree for BRI3BP (if available)
Gene Tree for BRI3BP (if available)

Paralogs for BRI3BP Gene Pseudogenes for BRI3BP Gene

genes like me logo Genes that share paralogs with BRI3BP: view

No data available for Paralogs for BRI3BP Gene

Variants for BRI3BP Gene

Sequence variations from dbSNP and Humsavar for BRI3BP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2880921 -- 125,017,003(+) GCTAA(C/T)GTTTG intron-variant
rs3751184 -- 125,012,509(+) TGGGT(A/G)ATGAC intron-variant
rs4418906 -- 124,996,289(+) ATGGG(G/T)ttttt intron-variant
rs4433660 -- 125,004,002(+) ACACA(A/C)AACAC intron-variant
rs4470002 -- 125,017,329(+) ttttt(A/T)ttttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BRI3BP Gene

Variant ID Type Subtype PubMed ID
nsv509485 CNV Insertion 20534489
esv998178 CNV Insertion 20482838
dgv325e199 CNV Deletion 23128226

Relevant External Links for BRI3BP Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRI3BP Gene

Disorders for BRI3BP Gene

(1) University of Copenhagen DISEASES for BRI3BP Gene

genes like me logo Genes that share disorders with BRI3BP: view

No data available for UniProtKB/Swiss-Prot for BRI3BP Gene

Publications for BRI3BP Gene

  1. Cloning, tissue expression pattern, and chromosome location of a novel human gene BRI3BP. (PMID: 11860200) Lin L. … Zhao S. (Biochem. Genet. 2001) 2 3 4 23
  2. Augmentation of drug-induced cell death by ER protein BRI3BP. (PMID: 17765869) Yamazaki T. … Takeshima H. (Biochem. Biophys. Res. Commun. 2007) 2 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. HCCRBP-1 directly interacting with HCCR-1 induces tumorigenesis through P53 stabilization. (PMID: 17943721) Ha S.A. … Kim J.W. (Int. J. Cancer 2008) 3 4
  5. Quantitative nanoproteomics for protein complexes (QNanoPX) related to estrogen transcriptional action. (PMID: 19805454) Cheng P.C. … Chen S.H. (Mol. Cell Proteomics 2010) 3

Products for BRI3BP Gene

Sources for BRI3BP Gene

Back to Top