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Aliases for BRI3 Gene

Aliases for BRI3 Gene

  • Brain Protein I3 2 3
  • PRGR2 3 4
  • I3 3

External Ids for BRI3 Gene

Previous GeneCards Identifiers for BRI3 Gene

  • GC07P096445
  • GC07P097479
  • GC07P097522
  • GC07P097555
  • GC07P097748
  • GC07P097910
  • GC07P092511

Summaries for BRI3 Gene

GeneCards Summary for BRI3 Gene

BRI3 (Brain Protein I3) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRI3 Gene

Genomics for BRI3 Gene

Regulatory Elements for BRI3 Gene

Genomic Location for BRI3 Gene

98,252,379 bp from pter
98,323,430 bp from pter
71,052 bases
Plus strand

Genomic View for BRI3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BRI3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRI3 Gene

Proteins for BRI3 Gene

  • Protein details for BRI3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Brain protein I3
    Protein Accession:
    Secondary Accessions:
    • D6W5R8
    • Q8WV52
    • Q9UIC6

    Protein attributes for BRI3 Gene

    125 amino acids
    Molecular mass:
    13645 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BRI3 Gene

Proteomics data for BRI3 Gene at MOPED

Post-translational modifications for BRI3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BRI3 Gene

No data available for DME Specific Peptides for BRI3 Gene

Domains for BRI3 Gene

Protein Domains for BRI3 Gene


Suggested Antigen Peptide Sequences for BRI3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O95415
  • Belongs to the BRI3 family.
genes like me logo Genes that share domains with BRI3: view

No data available for Gene Families for BRI3 Gene

Function for BRI3 Gene

Gene Ontology (GO) - Molecular Function for BRI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding IDA 15606899
genes like me logo Genes that share ontologies with BRI3: view

Phenotypes for BRI3 Gene

GenomeRNAi human phenotypes for BRI3:
genes like me logo Genes that share phenotypes with BRI3: view

Animal Model Products

CRISPR Products

miRNA for BRI3 Gene

miRTarBase miRNAs that target BRI3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for BRI3 Gene

Localization for BRI3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRI3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for BRI3 Gene COMPARTMENTS Subcellular localization image for BRI3 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for BRI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BRI3: view

Pathways for BRI3 Gene

SuperPathways for BRI3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BRI3 Gene


No data available for Pathways by source for BRI3 Gene

Transcripts for BRI3 Gene

Unigene Clusters for BRI3 Gene

Brain protein I3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BRI3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BRI3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP1: -
SP2: - -

Relevant External Links for BRI3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BRI3 Gene

mRNA expression in normal human tissues for BRI3 Gene

mRNA differential expression in normal tissues according to GTEx for BRI3 Gene

This gene is overexpressed in Whole Blood (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BRI3 Gene

SOURCE GeneReport for Unigene cluster for BRI3 Gene Hs.567438

genes like me logo Genes that share expressions with BRI3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for BRI3 Gene

Orthologs for BRI3 Gene

This gene was present in the common ancestor of animals.

Orthologs for BRI3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BRI3 35
  • 99.2 (n)
  • 100 (a)
BRI3 36
  • 100 (a)
(Bos Taurus)
Mammalia BRI3 35
  • 90.05 (n)
  • 91.13 (a)
BRI3 36
  • 91 (a)
(Canis familiaris)
Mammalia BRI3 35
  • 92.27 (n)
  • 95.2 (a)
BRI3 36
  • 94 (a)
(Mus musculus)
Mammalia Bri3 35
  • 89.6 (n)
  • 93.6 (a)
Bri3 16
Bri3 36
  • 93 (a)
(Monodelphis domestica)
Mammalia BRI3 36
  • 55 (a)
(Rattus norvegicus)
Mammalia Bri3 35
  • 87.47 (n)
  • 92.8 (a)
(Anolis carolinensis)
Reptilia BRI3 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bri3 35
  • 62.53 (n)
  • 56.2 (a)
(Danio rerio)
Actinopterygii bri3 35
  • 61.26 (n)
  • 55.86 (a)
bri3 36
  • 52 (a)
wufc63g12 35
fruit fly
(Drosophila melanogaster)
Insecta CG12012 36
  • 32 (a)
Species with no ortholog for BRI3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRI3 Gene

Gene Tree for BRI3 (if available)
Gene Tree for BRI3 (if available)

Paralogs for BRI3 Gene Pseudogenes for BRI3 Gene

genes like me logo Genes that share paralogs with BRI3: view

No data available for Paralogs for BRI3 Gene

Variants for BRI3 Gene

Sequence variations from dbSNP and Humsavar for BRI3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs14965 -- 98,282,352(+) ACAGG(G/T)ATACC reference, synonymous-codon, nc-transcript-variant
rs4075057 -- 98,289,136(-) TACTA(A/C)AAATA intron-variant
rs4075058 -- 98,289,009(-) CACTC(C/T)AGCCT intron-variant
rs4448203 -- 98,282,571(+) TTGAC(C/T)AGAGC intron-variant
rs4506131 -- 98,283,884(+) GATGG(C/G)CCAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BRI3 Gene

Variant ID Type Subtype PubMed ID
nsv888760 CNV Loss 21882294
nsv831067 CNV Loss 17160897

Relevant External Links for BRI3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRI3 Gene

Disorders for BRI3 Gene

No disorders were found for BRI3 Gene.

No data available for UniProtKB/Swiss-Prot for BRI3 Gene

Publications for BRI3 Gene

  1. bri3, a novel gene, participates in tumor necrosis factor-alpha-induced cell death. (PMID: 14592447) Wu H. … Zhao S. (Biochem. Biophys. Res. Commun. 2003) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin. (PMID: 15606899) Wickham L. … Seidah N.G. (J. Neurochem. 2005) 3
  4. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3
  5. Crystallization and preliminary X-ray analysis of the GST-fused human Bri3 N-terminal domain. (PMID: 16508092) Ye Q. … Jia Z. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2005) 3

Products for BRI3 Gene

Sources for BRI3 Gene

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