BRI3 Gene
protein-coding GIFtS: 44
GCID: GC07P097910
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|
brain protein I3
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Aliases
for BRI3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Brain Protein I31 2 | | PRGR21 | | I32 | | ITM2C5 |
Export aliases for BRI3 gene to outside databasesPrevious GC identifers: GC07P096445 GC07P097479 GC07P097522 GC07P097555 GC07P097748 GC07P092511 |
Summaries
for BRI3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for BRI3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the BRI3 gene promoter:
GR TBP USF1 AML1a USF-1 TFIID GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for BRI3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BRI3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q21.3 Ensembl cytogenetic band: 7q21.3 HGNC cytogenetic band: 7q21.3BRI3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P097910: view genomic region
(about GC identifiers)
Start:
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97,881,691 bp from pter |
End:
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97,937,162 bp from pter |
Size:
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55,472 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 97,235,846-97,247,141 |
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Proteins
for BRI3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: BRI3_HUMAN, O95415 (See
protein sequence)Recommended Name: Brain protein I3 Size: 125 amino acids; 13645 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: D6W5R8 Q8WV52 Q9UIC6Explore the universe of human proteins at neXtProt for BRI3: NX_O95415
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95415
BRI3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001152963.1 NP_056194.1
ENSEMBL proteins: ENSP00000440936 ENSP00000297290 ENSP00000459133
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
BRI3 for ontologies About GeneDecksing
BRI3 Antibody Products:
Assay Products for BRI3: |
Protein
Domains /
Families
for BRI3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
BRI3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O95415ProtoNet protein and cluster: O95415 UniProtKB/Swiss-Prot: BRI3_HUMAN, O95415Similarity: Belongs to the BRI3 family |
Function
for BRI3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BRI3 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BRI3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): BRI3 (NM_015379) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BRI3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRI3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRI3 |
2 GenomeRNAi human phenotypes for BRI3:
|
Pathways & Interactions
for BRI3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BRI3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/8 Interacting proteins for BRI3 (O954153 ENSP000002972904) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
|
Drugs & Compounds
for BRI3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BRI3
Search CenterWatch for drugs/clinical trials and news about BRI3
|
Transcripts
for BRI3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BRI3 gene (2 alternative transcripts): NM_001159491.1 NM_015379.4 Unigene Cluster for BRI3: Brain protein I3 Hs.567438 [show with all ESTs]Unigene Representative Sequence: BU5895437 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000456357 ENST00000539286(uc011kip.1) ENST00000297290(uc003upi.2)
ENST00000474291 ENST00000473967 ENST00000491463 ENST00000485422
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BRI3 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BRI3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): BRI3 (NM_015379) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BRI3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRI3 |
Additional cDNA sequence: AB055977.1 AF041430.2 AF106966.1 BC018737.1 BC062370.1 24/27 DOTS entries (see all 27): DT.97822032 DT.92464438 DT.95261785 DT.220268 DT.95261874 DT.101958256 DT.121050428 DT.92464427 DT.92464426 DT.97855670 DT.100893379 DT.100893415 DT.100893438 DT.121050419 DT.121050114 DT.92464430 DT.100689057 DT.70103235 DT.92464422 DT.92464453 DT.121050286 DT.75158089 DT.91970636 DT.92065366 24/1095 AceView cDNA sequences (see all 1095): BF590928 AI694436 AI651134 AI140226 AI824325 AI283009 AI247222 AI202119 AI695090 AI278755 H02024 AI091176 AI701836 AI299334 AI372001 AI381672 AI359579 BE467073 AI301755 AA902543 BE219780 BE468127 AI277107 AI084010
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for BRI3 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for BRI3
|
Expression
for BRI3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BRI3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACAACTCAAT
About this image
See BRI3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BRI3
SOURCE GeneReport for Unigene cluster: Hs.567438
SABiosciences Custom PCR Arrays for BRI3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BRI3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BRI3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BRI3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BRI3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRI3 |
Orthologs
for BRI3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for BRI3 gene from 6/16 species (see all 16) About this table
ENSEMBL Gene Tree for BRI3 (if available)
TreeFam Gene Tree for BRI3 (if available) |
Paralogs
for BRI3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BRI3 gene
BRI3 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for BRI3
PGOHUM00000239372 PGOHUM00000236944 PGOHUM00000244816
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Genomic Variants
for BRI3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BRI3 (97881691 - 97937162 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for BRI3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BRI3 |
|
Disorders
/ Diseases
for BRI3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BRI3 for disorders About GeneDecksing
OMIM gene information: 609554
OMIM disorders: --
2  diseases for BRI3: About MalaCardscolon cancer dementia
Export disorders for BRI3 gene to outside databases
|
Publications
for BRI3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BRI3 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with BRI3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- bri3, a novel gene, participates in tumor necrosis factor-alpha-induced cell death. (PubMed id 14592447)1, 3 Wu H....Zhao S. (2003)
- Analysis of the Wnt/B-catenin/TCF4 pathway using SAGE , genome-wide microarray and promoter analysis: Identification of BRI3 and HSF2 as novel targets. (PubMed id 20538055)1 Kavak E....Koman A. (2010)
- BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2. (PubMed id 19366692)1 Matsuda S....D'Adamio L. (2009)
- BRI3 associates with SCG10 and attenuates NGF-induced neurite outgrowth in PC12 cells. (PubMed id 18452648)1 Gong Y....Yuan J. (2008)
- A gene signature of 8 genes could identify the risk of recurrence and progression in Dukes' B colon cancer patients. (PubMed id 17390049)1 BandrAcs E....GarcA-a-Foncillas J. (2007)
- Crystallization and preliminary X-ray analysis of the GST-fused human Bri3 N-terminal domain. (PubMed id 16508092)1 Ye Q....Jia Z. (2005)
- Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin. (PubMed id 15606899)1 Wickham L.... Seidah N.G. (2005)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for BRI3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing BRI3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BRI3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BRI3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for BRI3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for BRI3 gene:
Search GeneIP for patents involving BRI3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BRI3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for BRI3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BRI3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BRI3 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BRI3 | | OriGene 3'-UTR Clone for BRI3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BRI3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BRI3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for BRI3 | | OriGene Custom Protein Services for BRI3 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BRI3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BRI3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BRI3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BRI3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BRI3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BRI3 |
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 |  |  |  | |
| | | | Search Tocris compounds for BRI3 |
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 | | | BRI3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRI3 |
|  |  |  | | | | Search ThermoFisher Antibodies for BRI3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRI3 |
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