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Aliases for BRI3 Gene

Aliases for BRI3 Gene

  • Brain Protein I3 2 3 5
  • PRGR2 3 4
  • I3 3

External Ids for BRI3 Gene

Previous GeneCards Identifiers for BRI3 Gene

  • GC07P096445
  • GC07P097479
  • GC07P097522
  • GC07P097555
  • GC07P097748
  • GC07P097910
  • GC07P092511

Summaries for BRI3 Gene

GeneCards Summary for BRI3 Gene

BRI3 (Brain Protein I3) is a Protein Coding gene. Among its related pathways are Immune System. GO annotations related to this gene include identical protein binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRI3 Gene

Genomics for BRI3 Gene

Regulatory Elements for BRI3 Gene

Enhancers for BRI3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F098280 1.4 FANTOM5 ENCODE 23.3 +32.1 32134 8.3 PKNOX1 ARID4B SIN3A FEZF1 ZNF48 YY1 ZNF121 GLIS2 FOS DEK BRI3 ENSG00000272950 BAIAP2L1 LMTK2
GH07F098398 1.4 FANTOM5 ENCODE 20.2 +147.6 147566 3.6 PKNOX1 ARNT SIN3A ZNF48 ZNF2 ZNF121 GLIS2 ZNF143 ZNF202 ZNF263 ENSG00000231859 TRRAP LOC101927550 BRI3 ENSG00000272950 RPS3AP26 SMURF1 LOC100419643 BAIAP2L1 GC07M098389
GH07F098350 1.3 Ensembl ENCODE 19.4 +105.4 105373 14.1 CREB3L1 ARID4B SIN3A BRCA1 YY1 GTF3C2 ZNF121 GATA2 FOS ZHX2 TRRAP ENSG00000272950 BRI3 BAIAP2L1 LOC100419643 LOC101927550 ENSG00000231859 SMURF1 RPS3AP26
GH07F098293 0.8 ENCODE 21.4 +42.5 42472 3.0 SIX4 CTCF KLF17 ARID4B GLI4 ZIC2 ZNF2 RAD21 E2F1 GLIS2 ENSG00000272950 BRI3 TECPR1 BHLHA15 BAIAP2L1
GH07F098328 0.8 Ensembl ENCODE 19.6 +77.0 77032 2.1 TAL1 GLIS1 BCL11B ZIC2 SPI1 ENSG00000272950 BRI3 BAIAP2L1 RPS3AP26
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around BRI3 on UCSC Golden Path with GeneCards custom track

Promoters for BRI3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001562147 -179 2001 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF143 FOS ZNF263 SP3

Genomic Location for BRI3 Gene

Chromosome:
7
Start:
98,252,379 bp from pter
End:
98,323,430 bp from pter
Size:
71,052 bases
Orientation:
Plus strand

Genomic View for BRI3 Gene

Genes around BRI3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRI3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRI3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRI3 Gene

Proteins for BRI3 Gene

  • Protein details for BRI3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95415-BRI3_HUMAN
    Recommended name:
    Brain protein I3
    Protein Accession:
    O95415
    Secondary Accessions:
    • D6W5R8
    • Q8WV52
    • Q9UIC6

    Protein attributes for BRI3 Gene

    Size:
    125 amino acids
    Molecular mass:
    13645 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BRI3 Gene

Post-translational modifications for BRI3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BRI3 Gene

Domains & Families for BRI3 Gene

Protein Domains for BRI3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BRI3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95415

UniProtKB/Swiss-Prot:

BRI3_HUMAN :
  • Belongs to the BRI3 family.
Family:
  • Belongs to the BRI3 family.
genes like me logo Genes that share domains with BRI3: view

No data available for Gene Families for BRI3 Gene

Function for BRI3 Gene

Gene Ontology (GO) - Molecular Function for BRI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding IDA 15606899
genes like me logo Genes that share ontologies with BRI3: view
genes like me logo Genes that share phenotypes with BRI3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for BRI3

miRNA for BRI3 Gene

miRTarBase miRNAs that target BRI3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BRI3 Gene

Localization for BRI3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRI3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for BRI3 gene
Compartment Confidence
plasma membrane 5
lysosome 4

Gene Ontology (GO) - Cellular Components for BRI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BRI3: view

Pathways & Interactions for BRI3 Gene

SuperPathway Contained pathways
1 Immune System
genes like me logo Genes that share pathways with BRI3: view

Pathways by source for BRI3 Gene

2 Reactome pathways for BRI3 Gene

Interacting Proteins for BRI3 Gene

Gene Ontology (GO) - Biological Process for BRI3 Gene

None

No data available for SIGNOR curated interactions for BRI3 Gene

Transcripts for BRI3 Gene

Unigene Clusters for BRI3 Gene

Brain protein I3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BRI3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP1: -
SP2: - -
SP3:

Relevant External Links for BRI3 Gene

GeneLoc Exon Structure for
BRI3
ECgene alternative splicing isoforms for
BRI3

Expression for BRI3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BRI3 Gene

mRNA differential expression in normal tissues according to GTEx for BRI3 Gene

This gene is overexpressed in Whole Blood (x5.4).

Protein differential expression in normal tissues from HIPED for BRI3 Gene

This gene is overexpressed in Gallbladder (18.2), Testis (15.1), Monocytes (12.1), Frontal cortex (9.6), and Islet of Langerhans (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BRI3 Gene



Protein tissue co-expression partners for BRI3 Gene

NURSA nuclear receptor signaling pathways regulating expression of BRI3 Gene:

BRI3

SOURCE GeneReport for Unigene cluster for BRI3 Gene:

Hs.567438
genes like me logo Genes that share expression patterns with BRI3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for BRI3 Gene

Orthologs for BRI3 Gene

This gene was present in the common ancestor of animals.

Orthologs for BRI3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BRI3 34 35
  • 99.2 (n)
dog
(Canis familiaris)
Mammalia BRI3 34 35
  • 92.27 (n)
cow
(Bos Taurus)
Mammalia BRI3 34 35
  • 90.05 (n)
mouse
(Mus musculus)
Mammalia Bri3 34 16 35
  • 89.6 (n)
rat
(Rattus norvegicus)
Mammalia Bri3 34
  • 87.47 (n)
oppossum
(Monodelphis domestica)
Mammalia BRI3 35
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BRI3 35
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bri3 34
  • 62.53 (n)
zebrafish
(Danio rerio)
Actinopterygii bri3 34 35
  • 61.26 (n)
wufc63g12 34
fruit fly
(Drosophila melanogaster)
Insecta CG12012 35
  • 32 (a)
OneToOne
Species where no ortholog for BRI3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRI3 Gene

ENSEMBL:
Gene Tree for BRI3 (if available)
TreeFam:
Gene Tree for BRI3 (if available)

Paralogs for BRI3 Gene

Pseudogenes.org Pseudogenes for BRI3 Gene

genes like me logo Genes that share paralogs with BRI3: view

No data available for Paralogs for BRI3 Gene

Variants for BRI3 Gene

Sequence variations from dbSNP and Humsavar for BRI3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1006169 -- 98,309,131(+) ACTTC(A/G)CTGGT intron-variant, utr-variant-3-prime
rs10226454 -- 98,286,373(+) GGAGT(A/C)GCCTT intron-variant
rs10237583 -- 98,287,150(+) GGGAC(A/G)GCTGG intron-variant
rs10237767 -- 98,294,421(+) GAAAA(C/T)GCTCT intron-variant
rs10267284 -- 98,287,171(+) CTCCC(A/G)GGCGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BRI3 Gene

Variant ID Type Subtype PubMed ID
nsv831067 CNV loss 17160897
nsv1076933 CNV deletion 25765185
dgv3623n106 CNV deletion 24896259

Variation tolerance for BRI3 Gene

Residual Variation Intolerance Score: 52.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BRI3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BRI3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRI3 Gene

Disorders for BRI3 Gene

Relevant External Links for BRI3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BRI3

No disorders were found for BRI3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BRI3 Gene

Publications for BRI3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. bri3, a novel gene, participates in tumor necrosis factor-alpha-induced cell death. (PMID: 14592447) Wu H. … Zhao S. (Biochem. Biophys. Res. Commun. 2003) 2 3 64
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3 64
  4. Analysis of the Wnt/B-catenin/TCF4 pathway using SAGE, genome-wide microarray and promoter analysis: Identification of BRI3 and HSF2 as novel targets. (PMID: 20538055) Kavak E. … Koman A. (Cell. Signal. 2010) 3 64
  5. BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2. (PMID: 19366692) Matsuda S. … D'Adamio L. (J. Biol. Chem. 2009) 3 64

Products for BRI3 Gene

Sources for BRI3 Gene

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