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BRI3 Gene

protein-coding   GIFtS: 47
GCID: GC07P097910

Brain Protein I3

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Brain Protein I31 2
pRGR22 3
I32

External Ids:    HGNC: 11091   Entrez Gene: 257982   Ensembl: ENSG000001647137   OMIM: 6156285   UniProtKB: O954153   

Export aliases for BRI3 gene to outside databases

Previous GC identifers: GC07P096445 GC07P097479 GC07P097522 GC07P097555 GC07P097748 GC07P092511


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for BRI3 Gene:
BRI3 (brain protein I3) is a protein-coding gene. Diseases associated with BRI3 include dementia.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BRI3 gene promoter:
         GR   TBP   USF1   AML1a   USF-1   TFIID   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBRI3 promoter sequence
   Search Chromatin IP Primers for BRI3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BRI3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.3   Ensembl cytogenetic band:  7q21.3   HGNC cytogenetic band: 7q21.3

BRI3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRI3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P097910:  view genomic region     (about GC identifiers)

Start:
97,881,691 bp from pter      End:
97,937,162 bp from pter
Size:
55,472 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 97,235,846-97,247,141     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: BRI3_HUMAN, O95415 (See protein sequence)
Recommended Name: Brain protein I3  
Size: 125 amino acids; 13645 Da
Secondary accessions: D6W5R8 Q8WV52 Q9UIC6

Explore the universe of human proteins at neXtProt for BRI3: NX_O95415

Explore proteomics data for BRI3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BRI3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001152963.1  NP_056194.1  

    ENSEMBL proteins: 
     ENSP00000440936   ENSP00000297290   ENSP00000459133  

    BRI3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for BRI3

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    LSBio Antibodies in human, mouse, rat for BRI3

    BRI3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BRI3
    Cloud-Clone Corp. CLIAs for BRI3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019317 Brain_I3

    Graphical View of Domain Structure for InterPro Entry O95415

    ProtoNet protein and cluster: O95415

    UniProtKB/Swiss-Prot: BRI3_HUMAN, O95415
    Similarity: Belongs to the BRI3 family


    BRI3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         2 GenomeRNAi human phenotypes for BRI3:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BRI3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BRI3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BRI3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BRI3

    miRNA
    Products:
        
    miRTarBase miRNAs that target BRI3:
    hsa-mir-484 (MIRT042003), hsa-let-7e-5p (MIRT051569)

    Block miRNA regulation of human, mouse, rat BRI3 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate BRI3:
    hsa-miR-3671 hsa-miR-323-3p hsa-miR-520d-5p hsa-miR-1224-3p hsa-miR-127-5p hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidBRI3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BRI3
    Predesigned siRNA for gene silencing in human, mouse, rat BRI3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BRI3

    Clone
    Products:
         
    OriGene clones in human, mouse for BRI3 (see all 13)
    OriGene ORF clones in mouse, rat for BRI3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): BRI3 (NM_015379)
    Sino Biological Human cDNA Clone for BRI3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BRI3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRI3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for BRI3
    Browse ESI BIO Cell Lines and PureStem Progenitors for BRI3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRI3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BRI3_HUMAN, O95415: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    BRI3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BRI3
    Interactions:

        GeneGlobe Interaction Network for BRI3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for BRI3 (O954153 ENSP000002972904) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BACE1P568173, ENSP000003185854I2D: score=1 STRING: ENSP00000318585
    SPRY2ENSP000003663064STRING: ENSP00000366306
    SPRY1ENSP000003437854STRING: ENSP00000343785
    RNF7ENSP000002734804STRING: ENSP00000273480
    NDFIP2ENSP000002186524STRING: ENSP00000218652
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BRI3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for BRI3 gene (2 alternative transcripts): 
    NM_001159491.1  NM_015379.4  

    Unigene Cluster for BRI3:

    Brain protein I3
    Hs.567438  [show with all ESTs]
    Unigene Representative Sequence: BU589543
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000456357 ENST00000539286(uc011kip.1) ENST00000297290(uc003upi.2)
    ENST00000474291 ENST00000473967 ENST00000491463 ENST00000485422
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat BRI3 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate BRI3:
    hsa-miR-3671 hsa-miR-323-3p hsa-miR-520d-5p hsa-miR-1224-3p hsa-miR-127-5p hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidBRI3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for BRI3
    Predesigned siRNA for gene silencing in human, mouse, rat BRI3
    Clone
    Products:
         
    OriGene clones in human, mouse for BRI3 (see all 13)
    OriGene ORF clones in mouse, rat for BRI3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): BRI3 (NM_015379)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BRI3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRI3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for BRI3
    OriGene qSTAR qPCR primer pairs in human, mouse for BRI3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BRI3
      QuantiTect SYBR Green Assays in human, mouse, rat BRI3
      QuantiFast Probe-based Assays in human, mouse, rat BRI3

    Additional mRNA sequence: 

    AB055977.1 AF041430.2 AF106966.1 BC018737.1 BC062370.1 

    Selected DOTS entries (see all 27):

    DT.97822032  DT.92464438  DT.95261785  DT.220268  DT.95261874  DT.101958256  DT.121050428  DT.92464427 
    DT.92464426  DT.97855670  DT.100893379  DT.100893415  DT.100893438  DT.121050419  DT.121050114  DT.92464430 
    DT.100689057  DT.70103235  DT.92464422  DT.92464453  DT.121050286  DT.75158089  DT.91970636  DT.92065366 

    Selected AceView cDNA sequences (see all 1095):

    AI651134 AI280960 AI219558 AW014601 AI301755 BE549513 AI470491 AI914333 
    AI091176 AI694436 AI283009 BF437938 AI359579 H02024 BE222157 BE219780 
    BE218713 AI695090 AI202119 AI246021 BF477550 AI824325 BF437876 AI301603 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for BRI3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
    SP1:                          -                     
    SP2:                    -     -                     
    SP3:                                                


    ECgene alternative splicing isoforms for BRI3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BRI3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAACTCAAT
    BRI3 Expression
    About this image

    BRI3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BRI3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567438
        Custom PCR Arrays for BRI3
    Primer
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    OriGene qPCR primer pairs and template standards for BRI3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRI3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BRI3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bri31 , 5 brain protein I31, 5 89.6(n)1
    93.6(a)1
      5 (83.19 cM)5
    559501  NM_018772.41  NP_061242.31 
     1442444375 
    lizard
    (Anolis carolinensis)
    Reptilia BRI36
    brain protein I3
    53(a)
    1 ↔ 1
    GL344247.1(24937-28073)
    African clawed frog
    (Xenopus laevis)
    Amphibia BI477836.12   -- 77.05(n)    BI477836.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc63g122 wufc63g12 76.78(n)   325268  CK145977.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG120126
    --
    32(a)
    1 ↔ 1
    3L(3376757-3377687)


    ENSEMBL Gene Tree for BRI3 (if available)
    TreeFam Gene Tree for BRI3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BRI3 gene

    BRI3 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for BRI3
    PGOHUM00000239372 PGOHUM00000236944 PGOHUM00000244816


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BRI3 (see all 282)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs119784201,2
    C,A,H--97909193(+) GACAGG/CAGGTA 2 -- us2k110Minor allele frequency- C:0.02NA WA CSA 251
    rs1824728481,2
    --97909205(+) AAGATC/TGATGG 2 -- us2k10--------
    rs132386101,2
    C,A--97909277(+) gctcaT/Cgccta 2 -- us2k14Minor allele frequency- C:0.31NA WA EA 360
    rs711121351,2
    C--97909548(-) TTTTT-/TTTTTT 2 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1443457811,2
    C--97909739(+) GGGCA-/ACATAG 2 -- us2k10--------
    rs1483389721,2
    C--97909795(+) GCGTGC/TGCCTG 2 -- us2k10--------
    rs1861641981,2
    --97909950(+) TTTTTA/TAAAAT 2 -- us2k10--------
    rs1910404501,2
    --97909951(+) TTTTAA/TAAATT 2 -- us2k10--------
    rs1415879861,2
    C--97910105(+) GCAATC/TCTGAA 2 -- us2k10--------
    rs1475274421,2
    --97910327(+) GGGCTA/GCCTGA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for BRI3 (97881691 - 97937162 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for BRI3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831067CNV Loss17160897
    nsv888760CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BRI3
    DNA2.0 Custom Variant and Variant Library Synthesis for BRI3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615628    OMIM disorders: --

    1 disease for BRI3:    About MalaCards
    dementia


    BRI3 for disorders           About GeneDecksing


    Export disorders for BRI3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BRI3 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with BRI3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. bri3, a novel gene, participates in tumor necrosis factor-alpha-induced cell death. (PubMed id 14592447)1, 3 Wu H....Zhao S. (Biochem. Biophys. Res. Commun. 2003)
    3. Analysis of the Wnt/B-catenin/TCF4 pathway using SAGE, genome-wide microarray and promoter analysis: Identification of BRI3 and HSF2 as novel targets. (PubMed id 20538055)1 Kavak E....Koman A. (Cell. Signal. 2010)
    4. BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2. (PubMed id 19366692)1 Matsuda S.... D'Adamio L. (J. Biol. Chem. 2009)
    5. BRI3 associates with SCG10 and attenuates NGF-induced neurite outgrowth in PC12 cells. (PubMed id 18452648)1 Gong Y....Yuan J. (BMB Rep. 2008)
    6. A gene signature of 8 genes could identify the risk of recurrence and progression in Dukes' B colon cancer patients. (PubMed id 17390049)1 BandrAcs E....GarcA-a-Foncillas J. (Oncol. Rep. 2007)
    7. Crystallization and preliminary X-ray analysis of the GST-fused human Bri3 N-terminal domain. (PubMed id 16508092)1 Ye Q....Jia Z. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2005)
    8. Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin. (PubMed id 15606899)1 Wickham L.... Seidah N.G. (J. Neurochem. 2005)
    9. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H.... Kim N.S. (Mamm. Genome 2005)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25798 HGNC: 1109 AceView: BRI3 Ensembl:ENSG00000164713 euGenes: HUgn25798
    ECgene: BRI3 H-InvDB: BRI3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BRI3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BRI3 gene:
    Search GeneIP for patents involving BRI3

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Block miRNA regulation of human, mouse, rat BRI3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing BRI3
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