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Aliases for BRI3 Gene

Aliases for BRI3 Gene

  • Brain Protein I3 2 3 5
  • PRGR2 3 4
  • I3 3

External Ids for BRI3 Gene

Previous GeneCards Identifiers for BRI3 Gene

  • GC07P096445
  • GC07P097479
  • GC07P097522
  • GC07P097555
  • GC07P097748
  • GC07P097910
  • GC07P092511

Summaries for BRI3 Gene

GeneCards Summary for BRI3 Gene

BRI3 (Brain Protein I3) is a Protein Coding gene. GO annotations related to this gene include identical protein binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRI3 Gene

Genomics for BRI3 Gene

Regulatory Elements for BRI3 Gene

Promoters for BRI3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BRI3 on UCSC Golden Path with GeneCards custom track

Genomic Location for BRI3 Gene

98,252,379 bp from pter
98,323,430 bp from pter
71,052 bases
Plus strand

Genomic View for BRI3 Gene

Genes around BRI3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRI3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRI3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRI3 Gene

Proteins for BRI3 Gene

  • Protein details for BRI3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Brain protein I3
    Protein Accession:
    Secondary Accessions:
    • D6W5R8
    • Q8WV52
    • Q9UIC6

    Protein attributes for BRI3 Gene

    125 amino acids
    Molecular mass:
    13645 Da
    Quaternary structure:
    No Data Available

neXtProt entry for BRI3 Gene

Proteomics data for BRI3 Gene at MOPED

Post-translational modifications for BRI3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BRI3 Gene

No data available for DME Specific Peptides for BRI3 Gene

Domains & Families for BRI3 Gene

Protein Domains for BRI3 Gene


Suggested Antigen Peptide Sequences for BRI3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BRI3 family.
  • Belongs to the BRI3 family.
genes like me logo Genes that share domains with BRI3: view

No data available for Gene Families for BRI3 Gene

Function for BRI3 Gene

genes like me logo Genes that share phenotypes with BRI3: view

Animal Model Products

miRNA for BRI3 Gene

miRTarBase miRNAs that target BRI3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BRI3 Gene

Localization for BRI3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRI3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for BRI3 Gene COMPARTMENTS Subcellular localization image for BRI3 gene
Compartment Confidence
plasma membrane 3
chloroplast 1

No data available for Gene Ontology (GO) - Cellular Components for BRI3 Gene

Pathways & Interactions for BRI3 Gene

SuperPathways for BRI3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BRI3 Gene


No data available for Pathways by source and SIGNOR curated interactions for BRI3 Gene

Drugs & Compounds for BRI3 Gene

No Compound Related Data Available

Transcripts for BRI3 Gene

Unigene Clusters for BRI3 Gene

Brain protein I3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BRI3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP1: -
SP2: - -

Relevant External Links for BRI3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BRI3 Gene

mRNA expression in normal human tissues for BRI3 Gene

mRNA differential expression in normal tissues according to GTEx for BRI3 Gene

This gene is overexpressed in Whole Blood (x5.4).

Protein differential expression in normal tissues from HIPED for BRI3 Gene

This gene is overexpressed in Gallbladder (18.2), Testis (15.1), Monocytes (12.1), Frontal cortex (9.6), and Islet of Langerhans (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BRI3 Gene

SOURCE GeneReport for Unigene cluster for BRI3 Gene Hs.567438

genes like me logo Genes that share expression patterns with BRI3: view

Protein tissue co-expression partners for BRI3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for BRI3 Gene

Orthologs for BRI3 Gene

This gene was present in the common ancestor of animals.

Orthologs for BRI3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BRI3 35
  • 90.05 (n)
  • 91.13 (a)
BRI3 36
  • 91 (a)
(Canis familiaris)
Mammalia BRI3 35
  • 92.27 (n)
  • 95.2 (a)
BRI3 36
  • 94 (a)
(Mus musculus)
Mammalia Bri3 35
  • 89.6 (n)
  • 93.6 (a)
Bri3 16
Bri3 36
  • 93 (a)
(Pan troglodytes)
Mammalia BRI3 35
  • 99.2 (n)
  • 100 (a)
BRI3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Bri3 35
  • 87.47 (n)
  • 92.8 (a)
(Monodelphis domestica)
Mammalia BRI3 36
  • 55 (a)
(Anolis carolinensis)
Reptilia BRI3 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bri3 35
  • 62.53 (n)
  • 56.2 (a)
(Danio rerio)
Actinopterygii bri3 35
  • 61.26 (n)
  • 55.86 (a)
wufc63g12 35
bri3 36
  • 52 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12012 36
  • 32 (a)
Species with no ortholog for BRI3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRI3 Gene

Gene Tree for BRI3 (if available)
Gene Tree for BRI3 (if available)

Paralogs for BRI3 Gene Pseudogenes for BRI3 Gene

genes like me logo Genes that share paralogs with BRI3: view

No data available for Paralogs for BRI3 Gene

Variants for BRI3 Gene

Sequence variations from dbSNP and Humsavar for BRI3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_033516 -
rs14965 -- 98,282,352(+) ACAGG(G/T)ATACC nc-transcript-variant, reference, synonymous-codon
rs4075057 -- 98,289,136(-) TACTA(A/C)AAATA intron-variant
rs4075058 -- 98,289,009(-) CACTC(C/T)AGCCT intron-variant
rs4506131 -- 98,283,884(+) GATGG(C/G)CCAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BRI3 Gene

Variant ID Type Subtype PubMed ID
nsv888760 CNV Loss 21882294
nsv831067 CNV Loss 17160897

Variation tolerance for BRI3 Gene

Residual Variation Intolerance Score: 52.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BRI3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRI3 Gene

Disorders for BRI3 Gene

Relevant External Links for BRI3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for BRI3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BRI3 Gene

Publications for BRI3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. bri3, a novel gene, participates in tumor necrosis factor-alpha-induced cell death. (PMID: 14592447) Wu H. … Zhao S. (Biochem. Biophys. Res. Commun. 2003) 2 3
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  4. Analysis of the Wnt/B-catenin/TCF4 pathway using SAGE, genome-wide microarray and promoter analysis: Identification of BRI3 and HSF2 as novel targets. (PMID: 20538055) Kavak E. … Koman A. (Cell. Signal. 2010) 3
  5. BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2. (PMID: 19366692) Matsuda S. … D'Adamio L. (J. Biol. Chem. 2009) 3

Products for BRI3 Gene

Sources for BRI3 Gene

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