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BRF2 Gene

protein-coding   GIFtS: 49
GCID: GC08M037701

BRF2, RNA Polymerase III Transcription Initiation Factor...

(Previous names: BRF2, subunit of RNA polymerase III transcription initiation...)
  See BRF2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
BRF2, RNA Polymerase III Transcription Initiation Factor 50 KDa
Subunit1 2
     hBRFU2 3
BRFU2 3 5     hTFIIIB502 3
TFIIIB502 3 5     RNA Polymerase III Transcription Initiation Factor BRFU2
BRF2, Subunit Of RNA Polymerase III Transcription Initiation Factor,
BRF1-Like1 2
     Transcription Factor IIB- Related Factor, TFIIIB502
BRF-22 3     Transcription Factor IIIB 50 KDa Subunit2
B-Related Factor 22 3     

External Ids:    HGNC: 172981   Entrez Gene: 552902   Ensembl: ENSG000001042217   OMIM: 6070135   UniProtKB: Q9HAW03   

Export aliases for BRF2 gene to outside databases

Previous GC identifers: GC08P029359 GC08P043602 GC08M037557 GC08M037758 GC08M037820 GC08M036235


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BRF2 Gene:
This gene encodes one of the multiple subunits of the RNA polymerase III transcription factor complex required for
transcription of genes with promoter elements upstream of the initiation site. The product of this gene, a
TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters
through its interaction with the TATA-binding protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for BRF2 Gene:
BRF2 (BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit) is a protein-coding gene. Diseases associated with BRF2 include lung squamous cell carcinoma.

UniProtKB/Swiss-Prot: BRF2_HUMAN, Q9HAW0
Function: General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase
III transcription of genes with promoter elements upstream of the initiation sites

Gene Wiki entry for BRF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the BRF2 gene promoter:
         TBP   AML1a   NF-E2 p45   E47   AREB6   FAC1   TFIID   FOXO4   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBRF2 promoter sequence
   Search Chromatin IP Primers for BRF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BRF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.23   Ensembl cytogenetic band:  8p11.23   HGNC cytogenetic band: 8p11.23

BRF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRF2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M037701:  view genomic region     (about GC identifiers)

Start:
37,700,786 bp from pter      End:
37,707,431 bp from pter
Size:
6,646 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: BRF2_HUMAN, Q9HAW0 (See protein sequence)
Recommended Name: Transcription factor IIIB 50 kDa subunit  
Size: 419 amino acids; 46533 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Component of TFIIIB complex. The TFIIIB complex has two activities, alpha and beta. The TFIIIB-alpha
activity complex is composed of TBP, BDP1, and a complex containing both BRF2 and at least four stably associated
proteins; this complex inhibits the transcription by pol III via its phosphorylation by CK2; YY1 facilitates the
TFIIIB-alpha complex formation. BRF2 recruitment to the TATA box containing small nuclear RNA (snRNA) gene
templates is TBP-dependent. Interacts with TBP; this interaction with TBP mediates its TATA-box recruitment of
these promoters. Interacts with TBP and the BURE sequence (GC-rich sequence downstream from the TATA box) to form
a strong ternary complex which is joined by BDP1; this ternary complex stimulates pol III transcription. Forms a
trimeric complex composed of TBP, BRF2 and mini-SNAPc complex (SNAP43, SNAP50, and the N-terminal third of
SNAP190) on the promoter. Assembly of the TBP-BRF2 complex is stimulated by SNAP190. Interacts with MAF1 and
SNAPC4
Sequence caution: Sequence=AAG35486.1; Type=Erroneous initiation;
Secondary accessions: B2RD62 D3DSW6 Q9H2Y3 Q9H3B3 Q9NUY6

Explore the universe of human proteins at neXtProt for BRF2: NX_Q9HAW0

Explore proteomics data for BRF2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys324
  • Modification sites at PhosphoSitePlus

  • See BRF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060780.2  
    ENSEMBL proteins: 
     ENSP00000220659   ENSP00000430107   ENSP00000430193   ENSP00000429554  
    Reactome Protein details: Q9HAW0

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    antibodies-online proteins for BRF2 (7 products) 

     
    antibodies-online peptides for BRF2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR000812 TFIIB
     IPR013763 Cyclin-like
     IPR013137 Znf_TFIIB

    Graphical View of Domain Structure for InterPro Entry Q9HAW0

    ProtoNet protein and cluster: Q9HAW0

    1 Blocks protein domain: IPB013137 Zinc finger

    UniProtKB/Swiss-Prot: BRF2_HUMAN, Q9HAW0
    Similarity: Belongs to the TFIIB family
    Similarity: Contains 1 TFIIB-type zinc finger


    Find genes that share domains with BRF2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BRF2_HUMAN, Q9HAW0
    Function: General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase
    III transcription of genes with promoter elements upstream of the initiation sites
    Induction: Down-regulated by epigallocatechin gallate (EGCG) treatment

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with BRF2           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for BRF2

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate BRF2 (see all 23):
    hsa-miR-4307 hsa-miR-300 hsa-let-7d hsa-let-7c hsa-miR-507 hsa-let-7g hsa-let-7a hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidBRF2 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRF2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BRF2_HUMAN, Q9HAW0: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with BRF2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BRF2 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase III Transcription Initiation
    RNA Polymerase III Transcription Initiation0.88
    RNA Polymerase III Transcription0.88
    RNA Polymerase III Abortive And Retractive Initiation0.88
    RNA Polymerase III Transcription Initiation From Type 3 Promoter0.80
    2Transcription of tRNA
    Assembly of RNA Polymerase-III Initiation Complex0.00
    Transcription of tRNA
    3RNA Polymerase I Promoter Opening
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.73
    4Gene Expression
    Gene Expression0.40
    5Translational Control
    Translational Control


    Find genes that share SuperPaths with BRF2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for BRF2
        Transcription of tRNA
    Assembly of RNA Polymerase-III Initiation Complex

    2 Cell Signaling Technology (CST) Pathways for BRF2
        Translational Control
    PI3K / Akt Signaling

    2 Reactome Pathways for BRF2
        RNA Polymerase III Transcription Initiation From Type 3 Promoter
    RNA Polymerase III Abortive And Retractive Initiation


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BRF2
    Interactions:

        GeneGlobe Interaction Network for BRF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BRF2 (Q9HAW03 ENSP000002206594) via UniProtKB, MINT, STRING, and/or I2D (see all 124)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TBPP202263, ENSP000002303544I2D: score=3 STRING: ENSP00000230354
    ABCD3P282883, ENSP000003592334I2D: score=2 STRING: ENSP00000359233
    AIFM1O958313, ENSP000002872954I2D: score=2 STRING: ENSP00000287295
    COPG1Q9Y6783, ENSP000003250024I2D: score=2 STRING: ENSP00000325002
    MYO1BO437953, ENSP000003063824I2D: score=2 STRING: ENSP00000306382
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006352DNA-templated transcription, initiation IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006383transcription from RNA polymerase III promoter TAS--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with BRF2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BRF2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BRF2 gene: 
    NM_018310.3  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000220659(uc003xkk.3) ENST00000520601 ENST00000521170 ENST00000522539

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate BRF2 (see all 23):
    hsa-miR-4307 hsa-miR-300 hsa-let-7d hsa-let-7c hsa-miR-507 hsa-let-7g hsa-let-7a hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidBRF2 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat BRF2
      QuantiFast Probe-based Assays in human, mouse, rat BRF2

    Selected AceView cDNA sequences (see all 147):

    BC010648 AI187099 NM_018310 CR604537 AL556835 AL560591 BM469513 CR616155 
    CR591369 CA420481 BU739386 AI200382 AI672711 AI417504 AI004499 BX384840 
    CR602291 BM714768 AF130058 BM682391 CR614939 BU682652 BU557148 BI828536 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for BRF2    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b
    SP1:                                -     -                                       
    SP2:                                -     -                       -               
    SP3:                                      -                                       
    SP4:                                                                              


    ECgene alternative splicing isoforms for BRF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BRF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGATCCTCTA
    BRF2 Expression
    About this image


    BRF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    BRF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BRF2 Protein Expression
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for BRF2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Brf21 , 5 BRF2, subunit of RNA polymerase III transcription initiation more1, 5 82.58(n)1
    82.58(a)1
      8 (15.91 cM)5
    666531  NM_025686.21  NP_079962.11 
     271238325 
    chicken
    (Gallus gallus)
    Aves BRF21 BRF2, subunit of RNA polymerase III transcription initiation more 63.07(n)
    59.8(a)
      426772  XM_424383.4  XP_424383.3 
    lizard
    (Anolis carolinensis)
    Reptilia BRF26
    BRF2, RNA polymerase III transcription initiation ...
    54(a)
    1 ↔ 1
    GL343406.1(429394-433934)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.46652 Xenopus laevis transcribed sequence with weak similarity more 78.59(n)    BU916635.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005365801 transcription factor IIIB 50 kDa subunit-like 50.8(n)
    41.35(a)
      100536580  XM_003201765.2  XP_003201813.1 


    ENSEMBL Gene Tree for BRF2 (if available)
    TreeFam Gene Tree for BRF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BRF2 gene
    1 SIMAP similar gene for BRF2 using alignment to 3 protein entries:     BRF2_HUMAN (see all proteins):
    IRF2

    Find genes that share paralogs with BRF2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BRF2 (see all 208)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1423953371,2
    Cuntested137704631(+) AACCGC/TGGTAT 2 T A mis11Minor allele frequency- T:0.00NA 4552
    rs759662251,2
    C--37702012(+) ATCAGA/GGAGGG 2 P L mis10--------
    rs1806750461,2
    C--37702029(+) ACACTC/TGTGGC 2 T syn10--------
    rs1413450381,2
    C--37702044(+) TGTCTA/GGCAGC 2 A syn10--------
    rs1448965271,2
    C,F--37702087(+) GGGTAC/TGCAAA 2 H R mis12Minor allele frequency- T:0.00NA EU 5871
    rs1479665641,2
    C,F--37702138(+) TGACAG/ATGGAG 2 /T /I mis11Minor allele frequency- A:0.00NA 4552
    rs2016173621,2
    C--37702166(+) GATCCA/GCTTCG 2 R W mis10--------
    rs1507856511,2
    C--37702255(+) TTCCCA/CCCTCC 2 G V mis10--------
    rs2014608661,2
    C--37702304(+) CTCTCG/AGGTCT 2 /R /* stg11Minor allele frequency- A:0.00EU 1323
    rs1405468931,2
    C,F--37702308(+) CGGGTC/GTCCAC 2 D E mis11Minor allele frequency- G:0.00NA 4408

    HapMap Linkage Disequilibrium report for BRF2 (37700786 - 37707431 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for BRF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509261CNV Insertion20534489
    nsv528598CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607013    OMIM disorders: --

    1 disease for BRF2:    
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    lung squamous cell carcinoma


    Find genes that share disorders with BRF2           About GenesLikeMe


    Export disorders for BRF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BRF2 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with BRF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. BRFU, a TFIIB-like factor, is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with TATA-binding protein. (PubMed id 11564744)1, 2, 3, 9 Cabart P. and Murphy S. (J. Biol. Chem. 2001)
    2. Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. (PubMed id 11483580)1, 2, 3 Yu Y....He F. (Genome Res. 2001)
    3. The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition. (PubMed id 12621023)1, 2, 9 Hinkley C.S.... Henry R.W. (J. Biol. Chem. 2003)
    4. Structure-function analysis of the human TFIIB-related factor II protein reveals an essential role for the C-terminal domain in RNA polymerase III transcription. (PubMed id 16227591)1, 2 Saxena A.... Hernandez N. (Mol. Cell. Biol. 2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. A stable complex of a novel transcription factor IIB- related factor, human TFIIIB50, and associated proteins mediate selective transcription by RNA polymerase III of genes with upstream promoter elements. (PubMed id 11121026)1, 2 Teichmann M.... Roeder R.G. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    7. Different human TFIIIB activities direct RNA polymerase III transcription from TATA-containing and TATA-less promoters. (PubMed id 11040218)1, 2 Schramm L.... Hernandez N. (Genes Dev. 2000)
    8. Differential expression of the TFIIIB subunits Brf1 and Brf2 in cancer cells. (PubMed id 18700021)1, 9 Cabarcas S....Schramm L. (BMC Mol. Biol. 2008)
    9. A role for Yin Yang-1 (YY1) in the assembly of snRNA transcription complexes. (PubMed id 16769183)2, 9 Emran F....Hernandez N. (Gene 2006)
    10. A minimal RNA polymerase III transcription system from human cells reveals positive and negative regulatory roles for CK2. (PubMed id 14527415)2, 9 Hu P.... Hernandez N. (Mol. Cell 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55290 HGNC: 17298 AceView: BRF2 Ensembl:ENSG00000104221 euGenes: HUgn55290
    ECgene: BRF2 H-InvDB: BRF2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BRF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BRF2 gene:
    Search GeneIP for patents involving BRF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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