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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BRF1 Gene

protein-coding GIFtS: 57
GCID: GC14M105675

BRF1 homolog, subunit of RNA polymerase III transcription...

(Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase...)
(Previous symbols: TAF3B2, TAF3C, GTF3B)

Explore 10 diseases affiliated with
BRF1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
BRF1 Homolog, Subunit Of RNA Polymerase III Transcription Initiation Factor IIIB (S. Cerevisiae)¹ ²		TAFIII90²
GTF3B¹ ² ³ ⁵		B - Related Factor 1²
TAF3C¹ ² ³ ⁵		General Transcription Factor IIIB, 90kD Subunit²
BRF¹ ² ³		TATA Box Binding Protein (TBP)-Associated Factor 3C²
TAF3B2¹ ² ³		TBP - Associated Factor, RNA Polymerase III, 90kD²
TFIIIB90¹ ² ³		Transcription Factor IIIB 90 KDa Subunit²
HBRF¹		B-Related Factor 1³
TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase III, GTF3B Subunit 2¹ ²		HTFIIIB90¹
BRF-1² ³		TATA Box-Binding Protein-Associated Factor, RNA Polymerase III, Subunit 2³
TF3B90² ⁵

External Ids:	HGNC: 11551¹	Entrez Gene: 2972²	Ensembl: ENSG00000185024⁷	OMIM: 604902⁵	UniProtKB: Q92994³

Export aliases for BRF1 gene to outside databases

Previous GC identifers: GC14M103054 GC14M099666 GC14M103647 GC14M104746 GC14M085867

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BRF1:

This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays

a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small

structural RNAs. The gene product belongs to the TF2B family. Several alternatively spliced variants encoding

different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified.

(provided by RefSeq, Jun 2011)

UniProtKB/Swiss-Prot: TF3B_HUMAN, Q92994

Function: General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct

promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is

required for transcription of the U6 promoter

Gene Wiki entry for BRF1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BRF1 gene promoter:
TBP AP-1 TFIID ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): BRF1 promoter sequence

Search SABiosciences Chromatin IP Primers for BRF1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BRF1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q Ensembl cytogenetic band: 14q32.33 HGNC cytogenetic band: 14q

BRF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRF1 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M105675: view genomic region (about GC identifiers)

Start:	105,675,623 bp from pter	End:	105,781,926 bp from pter
Size:	106,304 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TF3B_HUMAN, Q92994 (See protein sequence)

Recommended Name: Transcription factor IIIB 90 kDa subunit

Size: 677 amino acids; 73840 Da

Subunit: TFIIIB comprises at least the TATA-binding protein (TBP) and the B-related factor 1 (BRF1/TFIIIB90). Interacts

with BDP1

Subcellular location: Nucleus (By similarity)

Sequence caution: Sequence=AAC50170.1; Type=Frameshift; Positions=344, 405;

Secondary accessions: B3KU36 B4DIG5 B7Z2N3 F5H5Z7 F8WA46 Q13223 Q3SYD9 Q5PR24 Q6IQ02 Q96KX3 Q9HCW6

Q9HCW7 Q9HCW8

Alternative splicing: 9 isoforms: Q92994-1 Q92994-2 Q92994-3 Q92994-4 Q92994-5 Q92994-6 Q92994-7 Q92994-8

Q92994-9 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BRF1: NX_Q92994

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q92994

BRF1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (7 alternative transcripts):

NP_001229715.1 NP_001229716.1 NP_001229717.1 NP_001229718.1 NP_001229719.1 NP_001510.2 NP_663718.1

ENSEMBL proteins:

ENSP00000376340 ENSP00000369269 ENSP00000448323 ENSP00000448387 ENSP00000389859

ENSP00000446901 ENSP00000329029 ENSP00000388877 ENSP00000450151 ENSP00000448723

ENSP00000449788 ENSP00000450258 ENSP00000449173 ENSP00000447521 ENSP00000448823

ENSP00000446707 ENSP00000369264

Reactome Protein details: Q92994
Human Recombinant Protein Products:

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	Uscn Proteins for BRF1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000126	transcription factor TFIIIB complex	NAS	8943358
GO:0005634	nucleus	--	--
GO:0005654	nucleoplasm	TAS	--

BRF1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for BRF1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BRF1 for domains About GeneDecksing

5 InterPro domains/families:

IPR011665 BRF1_TBP-bd

IPR000812 TFIIB

IPR013150 TFIIB_cyclin

IPR013137 Znf_TFIIB

IPR013763 Cyclin-like

Graphical View of Domain Structure for InterPro Entry Q92994

ProtoNet protein and cluster: Q92994

4 Blocks protein families:

IPB000812 Transcription factor TFIIB family

IPB006670 Cyclin

IPB011665 Brf1-like TBP-binding

IPB013137 Zinc finger

UniProtKB/Swiss-Prot: TF3B_HUMAN, Q92994

Similarity: Belongs to the TFIIB family

Similarity: Contains 1 TFIIB-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TF3B_HUMAN, Q92994

Function: General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct

promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is

required for transcription of the U6 promoter

Genatlas biochemistry entry for BRF1:

butyrate response factor 1,member of the immediate early response gene family, specifying a putative nuclear

transcription factor

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRF1

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003743	translation initiation factor activity	--	--
GO:0008270	zinc ion binding	IEA	--
GO:0017025	TBP-class protein binding	IEA	--

BRF1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for BRF1:

Synthetic lethal with c-Myc af

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

RNA Polymerase III Transcription Initiation

RNA Polymerase III Transcription Initiation	1.00	RNA Polymerase III Transcription Initiation From Type 1 Promoter	0.77
RNA Polymerase III Abortive And Retractive Initiation	1.00	RNA Polymerase III Transcription Initiation From Type 2 Promoter	0.74
RNA Polymerase III Transcription	1.00	RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription	0.59

Integrated Pancreatic Cancer Pathway

Integrated Pancreatic Cancer Pathway

1.00

Integrated Pancreatic Cancer Pathway

0.99

Assembly of RNA Polymerase-III Initiation Complex

Assembly of RNA Polymerase-III Initiation Complex

1.00

Transcription of tRNA

0.83

Transcription

Transcription

1.00

Rho Family GTPases

ERK Signaling

0.61

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BRF1

	ERK Signaling
	Transcription of tRNA
	Assembly of RNA Polymerase-III Initiation Complex

2 BioSystems Pathways for BRF1

	Integrated Pancreatic Cancer Pathway
	Integrated Pancreatic Cancer Pathway

5/8 Reactome Pathways for BRF1 (see all 8)

	RNA Polymerase III Transcription Initiation
	Transcription
	RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
	RNA Polymerase III Abortive And Retractive Initiation
	RNA Polymerase III Transcription Initiation From Type 1 Promoter

BRF1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for BRF1

STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

5/24 Interacting proteins for BRF1 (Q92994^{2, 3} ENSP00000329029⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 24)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TBP	P20226²^,³, ENSP00000230354⁴	MINT-2859470 I2D: score=4 STRING: ENSP00000230354
RBL2	Q08999³, ENSP00000262133⁴	I2D: score=4 STRING: ENSP00000262133
TP53	P04637³, ENSP00000269305⁴	I2D: score=3 STRING: ENSP00000269305
DTNBP1	Q96EV8³, ENSP00000341680⁴	I2D: score=2 STRING: ENSP00000341680
GTF3C5	Q9Y5Q8³, ENSP00000361180⁴	I2D: score=2 STRING: ENSP00000361180

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006352	DNA-dependent transcription, initiation	--	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0006383	transcription from RNA polymerase III promoter	TAS	--
GO:0006384	transcription initiation from RNA polymerase III promoter	TAS	7624363
GO:0009303	rRNA transcription	TAS	7624363

BRF1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

BRF1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for BRF1
3 Novoseek chemical compound relationships for BRF1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
butyrate	62.4	8	12198173 (1), 15880358 (1), 15538381 (1), 18419273 (1) (see all 7)
trna	34.2	1	15592529 (1)
zinc	20.5	7	10733531 (3), 12198173 (2), 14518004 (1), 16227591 (1)

Search CenterWatch for drugs/clinical trials and news about BRF1 / TF3B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for BRF1 gene (8 alternative transcripts):

NM_001242786.1 NM_001242787.1 NM_001242788.1 NM_001242789.1 NM_001242790.1 NM_001519.3 NM_145685.2 NM_145696.1

Unigene Cluster for BRF1:

BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)

Hs.424484 [show with all ESTs]

Unigene Representative Sequence: NM_001519

18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):

ENST00000392557(uc001yql.2 uc001yqn.2 uc010axh.1 uc010axj.1)

ENST00000379937 ENST00000546474(uc001yqp.2 uc010axg.1 uc010tyo.1 uc010typ.1)

ENST00000547374(uc010axi.1) ENST00000547530(uc001yqk.2) ENST00000446501(uc001yqo.2)

ENST00000551787 ENST00000546997 ENST00000327359 ENST00000440513 ENST00000549044

ENST00000547562 ENST00000547052 ENST00000549655 ENST00000552127 ENST00000546417

ENST00000550208 ENST00000550375

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Additional cDNA sequence:

AJ297406.1 AJ297407.1 AJ297408.1 AK096471.1 AK124665.1 AK125024.1 AK126499.1 AK294899.1

AK295579.1 BC016743.2 BC071637.1 BC086856.1 BC103859.1 BC103860.2 BC103861.2 BC127832.1

BC133655.1 BC150588.1 U75276.1

15 DOTS entries:

DT.100789165 DT.413284 DT.120730112 DT.101955870 DT.101977952 DT.104677 DT.100789163 DT.101982454

DT.75103268 DT.95302185 DT.120730115 DT.100029563 DT.120730187 DT.75103267 DT.95272769

15 AceView cDNA sequences:

NM_001519 NM_145696 CR607892 AK124665 BC071637 NM_145685 AK125024 AK096471

U75276 AJ297406 BC016743 AK126499 AJ297407 AJ297408 U28838

GeneLoc Exon Structure

5/15 Alternative Splicing Database (ASD) splice patterns (SP) for BRF1 (see all 15) About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	·	7c	^	8	^	9a	·	9b	^	10a	·	10b	^	11	^	12a	·	12b	·	12c	^	13a	·	13b	·	13c	^	14	^	15a	·	15b	·	15c	·
SP1:									-				-		-		-		-																				-		-						-		-
SP2:			-						-				-		-		-		-																				-		-						-		-
SP3:																			-																				-		-						-		-
SP4:																																															-		-
SP5:																			-																		-		-		-		-		-		-		-		-

ExUns:	15d	·	15e	^	16	^	17a	·	17b	^	18	^	19	^	20	^	21	^	22
SP1:											-
SP2:											-
SP3:											-
SP4:											-
SP5:	-		-		-		-		-		-		-		-		-

ECgene alternative splicing isoforms for BRF1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BRF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See BRF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BRF1

SOURCE GeneReport for Unigene cluster: Hs.424484

SABiosciences Custom PCR Arrays for BRF1

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for BRF1 gene from 9/31 species (see all 31) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Brf1^{1 , 5}	BRF1 homolog, subunit of RNA polymerase III transcription more^{1, 5}	83.33(n)¹ 89.94(a)¹		12 (61.47 cM)⁵ 72308¹ NM_028193.3¹ NP_082469.2¹ 112959862⁵
chicken (Gallus gallus)	Aves	BRF1¹	BRF1 homolog, subunit of RNA polymerase III transcription more	72.65(n) 78.78(a)		423503 XM_421405.3 XP_421405.2
lizard (Anolis carolinensis)	Reptilia	BRF1⁶	--	79(a)	1 ↔ 1	1(1130586-1326734)
tropical clawed frog (Xenopus tropicalis)	Amphibia	AL871614.2²	--	78.35(n)		AL871614.2
zebrafish (Danio rerio)	Actinopterygii	wufi40c10²	wufi40c10	75.15(n)		334316 BC060523.1
fruit fly (Drosophila melanogaster)	Insecta	Brf^{1 , 3}	regulation of transcription from Pol III promoter more³ Brf¹	56(a)³ 52.93(n)¹ 45.83(a)¹		42087¹ NM_001170165.1¹ NP_001163636.1¹
worm (Caenorhabditis elegans)	Secernentea	brf-1^{1 , 3}	transcription initiation factor IIB³ Protein BRF-1¹	48(a)³ 45.01(n)¹ 43.37(a)¹		II(7305805-7308362)³ 174199¹ NM_063125.3¹ NP_495526.1¹
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G30455¹	transcription regulator / translation initiation factor more	50.49(n) 50(a)		6240845 NM_001123917.1 NP_001117389.1
rice (Oryza sativa)	Liliopsida	Os05g0305100¹	hypothetical protein	44.87(n) 38.03(a)		4338362 NM_001061682.1 NP_001055147.1

ENSEMBL Gene Tree for BRF1 (if available)
TreeFam Gene Tree for BRF1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs118091777^1,2	C,F,	--	105675216(+)	`CCCACC/TTGCAC`	6	--	ds500¹		1		EA	120
rs2312741^1,2	C,F,A,	--	105675235(-)	`CCCAGA/GGGCCC`	6	--	ds500¹		11		NA WA CSA	254
rs72709714^1,2	C,	--	105675337(+)	`CCGTTT/CCACTT`	6	--	ds500¹		3		NA WA	240
rs11846022^1,2	C,F,H,	--	105675399(+)	`GGGACT/CTGTCC`	6	--	ds500¹		12		NA WA CSA EA	378
rs75827858^1,2	F,	--	105675476(+)	`AGTAGT/CTGGGG`	6	--	ds500¹		1		WA	118
rs113283999^1,2		--	105675612(+)	`GACAAG/CCCTCA`	6	--	ds500¹		1		CSA	2
rs183332136^1,2		--	105675693(+)	`AGCCCA/TGGCAG`	6	--	ut3¹		0	--	--	--	--
rs113551076^1,2		--	105675695(+)	`CCCTGG/ACAGGA`	6	--	ut3¹		1		CSA	2
rs8270^1,2	C,F,O,A,H,	--	105675701(-)	`CCTGGG/TTCCTG`	6	--	ut3¹ ese³		24		MN NS EA NA WA CSA	2159
rs189190499^1,2	C,	--	105675872(+)	`GCCCCC/TTCGGC`	6	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for BRF1 (105675623 - 105781926 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 22 variations for BRF1
15/18 CNVs (see all 18): 29968 35208 31979 35203 29965 35205 71995 35206 3950 35204 71996 35207 23306 30666 53303
4 Indels: 25361 45236 42862 25360

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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BRF1 for disorders           About GeneDecksing

OMIM gene information: 604902    OMIM disorders: --

10 diseases for BRF1:    About MalaCards

hypobetalipoproteinemia squamous cell carcinoma vaccinia colon cancer

ataxia cervicitis schizophrenia carcinoma

malaria alcoholism

1 disease from the University of Copenhagen DISEASES database for BRF1:

Hypobetalipoproteinemia

1 Novoseek disease relationship for BRF1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	3	17968325 (2), 18394985 (1)

Human Genome Epidemiology (HuGE) Navigator: BRF1 (1 document)

Export disorders for BRF1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for BRF1 gene, integrated from 9 sources (see all 80):
(articles sorted by number of sources associating them with BRF1)

Utopia: connect your pdf to the dynamic
world of online information

RNA polymerase III transcription from the human U6 and adenovirus type 2 VAI promoters has different requirements for human BRF, a subunit of human TFIIIB. (PubMed id 8943358)^{1, 2, 3, 9} Mital R.... Hernandez N. (1996)
Structure and function of a human transcription factor TFIIIB subunit that is evolutionarily conserved and contains both TFIIB- and high- mobility-group protein 2-related domains. (PubMed id 7624363)^{1, 2, 3} Wang Z. and Roeder R.G. (1995)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Alternatively spliced hBRF variants function at different RNA polymerase III promoters. (PubMed id 10921893)^{1, 2} McCulloch V.... Lobo-Ruppert S.M. (2000)
Differential expression of the TFIIIB subunits Brf1 and Brf2 in cancer cells. (PubMed id 18700021)^{1, 9} Cabarcas S....Schramm L. (2008)
The AU-rich element mRNA decay-promoting activity of BRF1 is regulated by mitogen-activated protein kinase-activated protein kinase 2. (PubMed id 18326031)^{1, 9} Maitra S....Chen C.Y. (2008)
The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B. (PubMed id 15538381)^{1, 9} Schmidlin M....Moroni C. (2004)
Functional cloning of BRF1, a regulator of ARE-dependent mRNA turnover. (PubMed id 12198173)^{1, 9} Stoecklin G....Moroni C. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 2972	HGNC: 11551	AceView: BRF1	Ensembl:ENSG00000185024	euGenes: HUgn2972
ECgene: BRF1	H-InvDB: BRF1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for BRF1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for BRF1 gene
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Patent Information for BRF1 gene:
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GeneCards and IP:
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BRF1 (Gene Symbol)
BRF1 Homolog, Subunit Of RNA Polymerase III Transcription Initiation Factor IIIB (S. Cerevisiae)
GTF3B
TAF3C
BRF
TAF3B2
TFIIIB90
HBRF
TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase III, GTF3B Subunit 2
BRF-1
TF3B90
TAFIII90
B - Related Factor 1
General Transcription Factor IIIB, 90kD Subunit
TATA Box Binding Protein (TBP)-Associated Factor 3C
TBP - Associated Factor, RNA Polymerase III, 90kD
Transcription Factor IIIB 90 KDa Subunit
B-Related Factor 1
HTFIIIB90
TATA Box-Binding Protein-Associated Factor, RNA Polymerase III, Subunit 2

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BRF1 Gene

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