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Aliases for BRF1 Gene

Aliases for BRF1 Gene

  • BRF1, RNA Polymerase III Transcription Initiation Factor 90 KDa Subunit 2 3
  • GTF3B 3 4 6
  • TAF3C 3 4 6
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase III, GTF3B Subunit 2 2 3
  • TFIIIB90 3 4
  • TAF3B2 3 4
  • TF3B90 3 6
  • BRF-1 3 4
  • HBRF 3 4
  • BRF 3 4
  • BRF1 Homolog, Subunit Of RNA Polymerase III Transcription Initiation Factor IIIB (S. Cerevisiae) 2
  • BRF1 Homolog, Subunit Of RNA Polymerase III Transcription Initiation Factor IIIB 3
  • TATA Box-Binding Protein-Associated Factor, RNA Polymerase III, Subunit 2 4
  • TATA Box Binding Protein (TBP)-Associated Factor 3C 3
  • TBP - Associated Factor, RNA Polymerase III, 90kD 3
  • Epididymis Secretory Sperm Binding Protein Li 76p 3
  • General Transcription Factor IIIB, 90kD Subunit 3
  • Transcription Factor IIIB 90 KDa Subunit 3
  • B - Related Factor 1 3
  • B-Related Factor 1 4
  • HEL-S-76p 3
  • HTFIIIB90 4
  • TAFIII90 3
  • CFDS 3

External Ids for BRF1 Gene

Previous HGNC Symbols for BRF1 Gene

  • TAF3B2
  • TAF3C
  • GTF3B

Previous GeneCards Identifiers for BRF1 Gene

  • GC14M103054
  • GC14M099666
  • GC14M103647
  • GC14M104746
  • GC14M105675
  • GC14M085867

Summaries for BRF1 Gene

Entrez Gene Summary for BRF1 Gene

  • This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Several alternatively spliced variants encoding different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified. [provided by RefSeq, Jun 2011]

GeneCards Summary for BRF1 Gene

BRF1 (BRF1, RNA Polymerase III Transcription Initiation Factor 90 KDa Subunit) is a Protein Coding gene. Diseases associated with BRF1 include cerebellofaciodental syndrome. Among its related pathways are ERK Signaling and Integrated Pancreatic Cancer Pathway. GO annotations related to this gene include TBP-class protein binding.

UniProtKB/Swiss-Prot for BRF1 Gene

  • General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter

Gene Wiki entry for BRF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRF1 Gene

Genomics for BRF1 Gene

Regulatory Elements for BRF1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BRF1 Gene

Start:
105,209,286 bp from pter
End:
105,315,589 bp from pter
Size:
106,304 bases
Orientation:
Minus strand

Genomic View for BRF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BRF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRF1 Gene

Proteins for BRF1 Gene

  • Protein details for BRF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92994-TF3B_HUMAN
    Recommended name:
    Transcription factor IIIB 90 kDa subunit
    Protein Accession:
    Q92994
    Secondary Accessions:
    • B3KU36
    • B4DIG5
    • B7Z2N3
    • F5H5Z7
    • F8WA46
    • Q13223
    • Q3SYD9
    • Q5PR24
    • Q6IQ02
    • Q96KX3
    • Q9HCW6
    • Q9HCW7
    • Q9HCW8

    Protein attributes for BRF1 Gene

    Size:
    677 amino acids
    Molecular mass:
    73840 Da
    Quaternary structure:
    • TFIIIB comprises at least the TATA-binding protein (TBP) and the B-related factor 1 (BRF1/TFIIIB90). Interacts with BDP1.
    SequenceCaution:
    • Sequence=AAC50170.1; Type=Frameshift; Positions=344, 405; Evidence={ECO:0000305};

    Alternative splice isoforms for BRF1 Gene

neXtProt entry for BRF1 Gene

Proteomics data for BRF1 Gene at MOPED

Post-translational modifications for BRF1 Gene

  • Ubiquitination at Lys537
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for BRF1 Gene

Domains for BRF1 Gene

Gene Families for BRF1 Gene

HGNC:
  • GTF :General transcription factors

Graphical View of Domain Structure for InterPro Entry

Q92994

UniProtKB/Swiss-Prot:

TF3B_HUMAN :
  • Q92994
Family:
  • Belongs to the TFIIB family.
Similarity:
  • Contains 1 TFIIB-type zinc finger.
genes like me logo Genes that share domains with BRF1: view

Function for BRF1 Gene

Molecular function for BRF1 Gene

GENATLAS Biochemistry: butyrate response factor 1,member of the immediate early response gene family, specifying a putative nuclear transcription factor
UniProtKB/Swiss-Prot Function: General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter

Gene Ontology (GO) - Molecular Function for BRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0017025 TBP-class protein binding IEA --
genes like me logo Genes that share ontologies with BRF1: view

Phenotypes for BRF1 Gene

GenomeRNAi human phenotypes for BRF1:
genes like me logo Genes that share phenotypes with BRF1: view

Animal Model Products

miRNA for BRF1 Gene

miRTarBase miRNAs that target BRF1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for BRF1 Gene

Localization for BRF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BRF1 Gene COMPARTMENTS Subcellular localization image for BRF1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for BRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000126 transcription factor TFIIIB complex NAS 8943358
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with BRF1: view

Pathways for BRF1 Gene

genes like me logo Genes that share pathways with BRF1: view

Gene Ontology (GO) - Biological Process for BRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006352 DNA-templated transcription, initiation --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006383 transcription from RNA polymerase III promoter TAS --
GO:0006384 transcription initiation from RNA polymerase III promoter IEA --
GO:0009303 rRNA transcription TAS 7624363
genes like me logo Genes that share ontologies with BRF1: view

Compounds for BRF1 Gene

(3) Novoseek inferred chemical compound relationships for BRF1 Gene

Compound -log(P) Hits PubMed IDs
butyrate 62.4 7
trna 34.2 1
zinc 20.5 7
genes like me logo Genes that share compounds with BRF1: view

Transcripts for BRF1 Gene

Unigene Clusters for BRF1 Gene

BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BRF1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BRF1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b · 15c ·
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - -
SP4: - -
SP5: - - - - - - - - -
SP6: - - - -
SP7: - - -
SP8: - - - -
SP9: - -
SP10:
SP11:
SP12:
SP13: - - -
SP14: - -
SP15: - -

ExUns: 15d · 15e ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1: -
SP2: -
SP3: -
SP4: -
SP5: - - - - - - - - -
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for BRF1 Gene

GeneLoc Exon Structure for
BRF1
ECgene alternative splicing isoforms for
BRF1

Expression for BRF1 Gene

mRNA expression in normal human tissues for BRF1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BRF1 Gene

SOURCE GeneReport for Unigene cluster for BRF1 Gene Hs.424484

genes like me logo Genes that share expressions with BRF1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BRF1 Gene

Orthologs for BRF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BRF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BRF1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BRF1 35
  • 82.81 (n)
  • 86.28 (a)
BRF1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BRF1 35
  • 85.62 (n)
  • 88.95 (a)
BRF1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Brf1 35
  • 83.33 (n)
  • 89.94 (a)
Brf1 16
Brf1 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BRF1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BRF1 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Brf1 35
  • 79.84 (n)
  • 84.43 (a)
chicken
(Gallus gallus)
Aves BRF1 35
  • 72.12 (n)
  • 78.08 (a)
BRF1 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BRF1 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia brf1 35
  • 69.55 (n)
  • 74.39 (a)
zebrafish
(Danio rerio)
Actinopterygii brf1b 35
  • 66.52 (n)
  • 68.16 (a)
brf1b 36
  • 64 (a)
OneToOne
wufi40c10 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004233 35
  • 54.68 (n)
  • 48.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta Brf 35
  • 55.47 (n)
  • 51.63 (a)
Brf 36
  • 43 (a)
OneToOne
Brf 37
  • 56 (a)
worm
(Caenorhabditis elegans)
Secernentea brf-1 35
  • 45.85 (n)
  • 44.94 (a)
brf-1 36
  • 32 (a)
OneToOne
brf-1 37
  • 48 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL213W 35
  • 49.54 (n)
  • 38.74 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BRF1 35
  • 48.06 (n)
  • 44.18 (a)
BRF1 36
  • 30 (a)
OneToOne
BRF1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A05434g 35
  • 43.75 (n)
  • 37.33 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes brf1 35
  • 46.28 (n)
  • 44.67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6827 36
  • 46 (a)
OneToOne
Species with no ortholog for BRF1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BRF1 Gene

ENSEMBL:
Gene Tree for BRF1 (if available)
TreeFam:
Gene Tree for BRF1 (if available)

Paralogs for BRF1 Gene

No data available for Paralogs for BRF1 Gene

Variants for BRF1 Gene

Sequence variations from dbSNP and Humsavar for BRF1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs8270 -- 105,209,364(-) CCTGG(G/T)TCCTG utr-variant-3-prime
rs760270 -- 105,271,448(-) CCACA(C/T)GTCTG intron-variant
rs941388 -- 105,240,876(-) GGCTG(C/T)CAGGC intron-variant
rs1008628 -- 105,256,389(-) TGCCC(A/G)GTCAG intron-variant, reference, synonymous-codon
rs1008629 -- 105,254,117(-) GTGTG(G/T)AGTTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for BRF1 Gene

Variant ID Type Subtype PubMed ID
dgv2020n71 CNV Loss 21882294
nsv456458 CNV Loss 19166990
nsv902424 CNV Loss 21882294
nsv902425 CNV Loss 21882294
nsv9175 CNV Gain 18304495
dgv659e1 CNV Complex 17122850
dgv2021n71 CNV Loss 21882294
nsv470679 CNV Loss 18288195
nsv902433 CNV Loss 21882294
dgv2023n71 CNV Gain+Loss 21882294
nsv902441 CNV Loss 21882294
dgv2024n71 CNV Loss 21882294
dgv2025n71 CNV Loss 21882294
nsv517055 CNV Gain+Loss 19592680
dgv267n27 CNV Loss 19166990
dgv2026n71 CNV Gain 21882294
dgv2027n71 CNV Gain+Loss 21882294
dgv2029n71 CNV Loss 21882294
dgv2030n71 CNV Loss 21882294
nsv510651 CNV Loss 20534489
nsv1439 CNV Insertion 18451855
esv2749282 CNV Deletion 23290073
nsv827085 CNV Gain 20364138
nsv9176 CNV Gain+Loss 18304495
esv2749283 CNV Deletion 23290073
esv1010073 CNV Gain 20482838
esv21762 CNV Gain+Loss 19812545
nsv902466 CNV Gain 21882294
esv2749284 CNV Deletion 23290073
esv2749286 CNV Deletion 23290073
esv29986 CNV Loss 17803354
dgv2031n71 CNV Loss 21882294
dgv26n68 CNV Loss 17160897
esv2953 CNV Deletion 18987735
dgv311e201 CNV Deletion 23290073
esv2749288 CNV Deletion 23290073
esv2265156 CNV Deletion 18987734
esv2749290 CNV Deletion 23290073
esv22709 CNV Gain+Loss 19812545
esv2749291 CNV Deletion 23290073
esv1410440 CNV Deletion 17803354
esv1158096 CNV Deletion 17803354
nsv832889 CNV Loss 17160897
dgv2032n71 CNV Loss 21882294
dgv2033n71 CNV Loss 21882294
dgv2034n71 CNV Loss 21882294
nsv902473 CNV Loss 21882294
nsv832890 CNV Loss 17160897
esv2749292 CNV Deletion 23290073
esv24753 CNV Loss 19812545
nsv511535 CNV Gain 21212237

Relevant External Links for BRF1 Gene

HapMap Linkage Disequilibrium report
BRF1
Human Gene Mutation Database (HGMD)
BRF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRF1 Gene

Disorders for BRF1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for BRF1 Gene including...

Search for BRF1 Gene in MalaCards »

UniProtKB/Swiss-Prot

TF3B_HUMAN
  • Cerebellofaciodental syndrome (CFDS) [MIM:616202]: An autosomal recessive disorder characterized by cerebellar hypoplasia, delayed development and intellectual disability, as well as facial dysmorphic features, short stature, microcephaly, and dental anomalies. {ECO:0000269 PubMed:25561519}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for BRF1 Gene

(1) Novoseek inferred disease relationships for BRF1 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 3

Relevant External Links for BRF1

Genetic Association Database (GAD)
BRF1
Human Genome Epidemiology (HuGE) Navigator
BRF1
genes like me logo Genes that share disorders with BRF1: view

Publications for BRF1 Gene

  1. RNA polymerase III transcription from the human U6 and adenovirus type 2 VAI promoters has different requirements for human BRF, a subunit of human TFIIIB. (PMID: 8943358) Mital R. … Hernandez N. (Mol. Cell. Biol. 1996) 2 3 4 23
  2. Structure and function of a human transcription factor TFIIIB subunit that is evolutionarily conserved and contains both TFIIB- and high- mobility-group protein 2-related domains. (PMID: 7624363) Wang Z. … Roeder R.G. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4
  3. Alternatively spliced hBRF variants function at different RNA polymerase III promoters. (PMID: 10921893) McCulloch V. … Lobo-Ruppert S.M. (EMBO J. 2000) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. New gene functions in megakaryopoiesis and platelet formation. (PMID: 22139419) Gieger C. … Soranzo N. (Nature 2011) 3 48

Products for BRF1 Gene

Sources for BRF1 Gene

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