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Aliases for BRE Gene

Aliases for BRE Gene

  • Brain And Reproductive Organ-Expressed (TNFRSF1A Modulator) 2 3 5
  • Brain And Reproductive Organ-Expressed Protein 3 4
  • BRCA1/BRCA2-Containing Complex Subunit 45 3 4
  • BRCC45 3 4
  • BRCA1/BRCA2-Containing Complex, Subunit 4 3
  • BRCA1/BRCA2-Containing Complex 2
  • Subunit 4 2
  • BRCC4 3

External Ids for BRE Gene

Previous GeneCards Identifiers for BRE Gene

  • GC02P028034
  • GC02P028206
  • GC02P028088
  • GC02P028025

Summaries for BRE Gene

GeneCards Summary for BRE Gene

BRE (Brain And Reproductive Organ-Expressed (TNFRSF1A Modulator)) is a Protein Coding gene. Among its related pathways are DNA Damage and Cell Cycle, Mitotic. GO annotations related to this gene include tumor necrosis factor receptor binding and peroxisome targeting sequence binding.

UniProtKB/Swiss-Prot for BRE Gene

  • Component of the BRCA1-A complex, a complex that specifically recognizes Lys-63-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes Lys-63-linked ubiquitin on histones H2A and H2AX (PubMed:17525341, PubMed:19261746, PubMed:19261749, PubMed:19261748). In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer (PubMed:21282113, PubMed:19261748). Component of the BRISC complex, a multiprotein complex that specifically cleaves Lys-63-linked ubiquitin in various substrates (PubMed:19214193, PubMed:24075985, PubMed:25283148, PubMed:26195665). Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity (PubMed:21282113). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect (PubMed:15465831).

Gene Wiki entry for BRE Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRE Gene

Genomics for BRE Gene

Regulatory Elements for BRE Gene

Enhancers for BRE Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BRE on UCSC Golden Path with GeneCards custom track

Promoters for BRE Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BRE on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the BRE gene promoter:

Genomic Location for BRE Gene

Chromosome:
2
Start:
27,889,941 bp from pter
End:
28,338,901 bp from pter
Size:
448,961 bases
Orientation:
Plus strand

Genomic View for BRE Gene

Genes around BRE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRE Gene

Proteins for BRE Gene

  • Protein details for BRE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXR7-BRE_HUMAN
    Recommended name:
    BRCA1-A complex subunit BRE
    Protein Accession:
    Q9NXR7
    Secondary Accessions:
    • A8K4X1
    • D6W562
    • D6W563
    • Q13880
    • Q4ZFX8
    • Q53SD0
    • Q969X9
    • Q96P06

    Protein attributes for BRE Gene

    Size:
    383 amino acids
    Molecular mass:
    43552 Da
    Quaternary structure:
    • Component of the ARISC complex, at least composed of UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1 (PubMed:21282113, PubMed:24075985). Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with FAM175A/Abraxas, BRCC3/BRCC36 and BABAM1/NBA1. Binds polyubiquitin. Component of the BRISC complex, at least composed of FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1 (PubMed:19214193, PubMed:21282113, PubMed:24075985, PubMed:25283148). Identified in a complex with SHMT2 and the other subunits of the BRISC complex (PubMed:24075985). Component of the BRCA1/BRCA2 containing complex (BRCC), which also contains BRCA1, BRCA2, BARD1, BRCC3/BRCC36 and RAD51. BRCC is a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage. May interact with FAS and TNFRSF1A (PubMed:15465831).

    Alternative splice isoforms for BRE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BRE Gene

Proteomics data for BRE Gene at MOPED

Post-translational modifications for BRE Gene

  • Ubiquitination at Lys 26, Lys 41, Lys 162, Lys 367, and Lys 382
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for BRE (BRE)

No data available for DME Specific Peptides for BRE Gene

Domains & Families for BRE Gene

Protein Domains for BRE Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for BRE Gene

Graphical View of Domain Structure for InterPro Entry

Q9NXR7

UniProtKB/Swiss-Prot:

BRE_HUMAN :
  • Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.
  • Belongs to the BRE family.
Domain:
  • Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.
Family:
  • Belongs to the BRE family.
genes like me logo Genes that share domains with BRE: view

No data available for Gene Families for BRE Gene

Function for BRE Gene

Molecular function for BRE Gene

UniProtKB/Swiss-Prot Function:
Component of the BRCA1-A complex, a complex that specifically recognizes Lys-63-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes Lys-63-linked ubiquitin on histones H2A and H2AX (PubMed:17525341, PubMed:19261746, PubMed:19261749, PubMed:19261748). In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer (PubMed:21282113, PubMed:19261748). Component of the BRISC complex, a multiprotein complex that specifically cleaves Lys-63-linked ubiquitin in various substrates (PubMed:19214193, PubMed:24075985, PubMed:25283148, PubMed:26195665). Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity (PubMed:21282113). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect (PubMed:15465831).
UniProtKB/Swiss-Prot Induction:
Down-regulated by DNA-damaging agents in fibroblasts, by retinoic acid in brain glioma U-251MG and promyelocytic HL-60 cell lines, and by bacterial lipopolysaccharides (LPS) in peripheral blood mononuclear cells (PBMC).
genes like me logo Genes that share phenotypes with BRE: view

Animal Models for BRE Gene

MGI Knock Outs for BRE:
  • Bre tm1a(EUCOMM)Wtsi

Animal Model Products

miRNA for BRE Gene

miRTarBase miRNAs that target BRE

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BRE Gene

Localization for BRE Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRE Gene

Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). {ECO:0000269 PubMed:19261748}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BRE Gene COMPARTMENTS Subcellular localization image for BRE gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BRE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with BRE: view

Pathways & Interactions for BRE Gene

genes like me logo Genes that share pathways with BRE: view

Pathways by source for BRE Gene

1 Cell Signaling Technology pathway for BRE Gene

Gene Ontology (GO) - Biological Process for BRE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006303 double-strand break repair via nonhomologous end joining TAS --
GO:0007165 signal transduction TAS 9737713
GO:0010212 response to ionizing radiation IMP 19261748
GO:0016568 chromatin modification IEA --
GO:0031572 G2 DNA damage checkpoint IMP 19261748
genes like me logo Genes that share ontologies with BRE: view

No data available for SIGNOR curated interactions for BRE Gene

Drugs & Compounds for BRE Gene

No Compound Related Data Available

Transcripts for BRE Gene

Unigene Clusters for BRE Gene

Brain and reproductive organ-expressed (TNFRSF1A modulator):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BRE Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b
SP1: -
SP2:
SP3: - -
SP4: -
SP5:
SP6: - -
SP7:

Relevant External Links for BRE Gene

GeneLoc Exon Structure for
BRE
ECgene alternative splicing isoforms for
BRE

Expression for BRE Gene

mRNA expression in normal human tissues for BRE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BRE Gene

This gene is overexpressed in Adrenal Gland (x12.5).

Protein differential expression in normal tissues from HIPED for BRE Gene

This gene is overexpressed in Bone (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BRE Gene



SOURCE GeneReport for Unigene cluster for BRE Gene Hs.258314

mRNA Expression by UniProt/SwissProt for BRE Gene

Q9NXR7-BRE_HUMAN
Tissue specificity: Expressed in all cell lines examined. Highly expressed in placenta.
genes like me logo Genes that share expression patterns with BRE: view

Protein tissue co-expression partners for BRE Gene

- Elite partner

In Situ Assay Products

Orthologs for BRE Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BRE Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BRE 35
  • 92.95 (n)
  • 99.74 (a)
BRE 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BRE 35
  • 94.17 (n)
  • 99.48 (a)
BRE 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BRE 35
  • 99.56 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Bre 35
  • 90.34 (n)
  • 98.96 (a)
mouse
(Mus musculus)
Mammalia Bre 16
Bre 36
  • 83 (a)
OneToOne
Bre 35
  • 90.25 (n)
  • 99.22 (a)
oppossum
(Monodelphis domestica)
Mammalia BRE 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BRE 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves BRE 35
  • 82.51 (n)
  • 97.65 (a)
BRE 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BRE 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bre 35
  • 78.33 (n)
  • 93.47 (a)
Str.8399 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6907 35
zebrafish
(Danio rerio)
Actinopterygii bre 35
  • 73.98 (n)
  • 84.33 (a)
bre 36
  • 80 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G42470 35
  • 44.55 (n)
  • 30.19 (a)
rice
(Oryza sativa)
Liliopsida Os06g0715600 35
  • 43.99 (n)
  • 32.59 (a)
Species with no ortholog for BRE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRE Gene

ENSEMBL:
Gene Tree for BRE (if available)
TreeFam:
Gene Tree for BRE (if available)

Paralogs for BRE Gene

No data available for Paralogs for BRE Gene

Variants for BRE Gene

Sequence variations from dbSNP and Humsavar for BRE Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs717126 -- 27,920,443(-) ACTCA(G/T)TTTCA intron-variant
rs1565326 -- 28,334,213(+) TAAAA(C/T)GTGCT intron-variant
rs1802747 -- 28,338,735(+) TCTTT(A/C)TTGCC utr-variant-3-prime
rs1812349 -- 28,240,895(-) aATGG(G/T)ttttt intron-variant
rs870968 -- 28,281,101(+) ATTCA(A/G)TCCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BRE Gene

Variant ID Type Subtype PubMed ID
nsv873758 CNV Loss 21882294
nsv873759 CNV Loss 21882294
dgv1162e1 CNV Complex 17122850
nsv873760 CNV Loss 21882294
nsv873761 CNV Loss 21882294
esv271229 CNV Insertion 20981092
nsv873762 CNV Loss 21882294
esv33936 CNV Loss 17666407
esv2659295 CNV Deletion 23128226
esv2470846 CNV Deletion 19546169
esv2252743 CNV Deletion 18987734
esv2719837 CNV Deletion 23290073
esv3893 CNV Deletion 18987735
esv2667473 CNV Deletion 23128226
nsv516533 CNV Loss 19592680
nsv527688 CNV Loss 19592680
nsv215424 CNV Loss 16902084
esv9589 CNV Gain 19470904
nsv873763 CNV Loss 21882294
nsv873764 CNV Loss 21882294
nsv819706 CNV Gain 19587683
nsv833625 CNV Loss 17160897

Variation tolerance for BRE Gene

Residual Variation Intolerance Score: 13.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BRE Gene

HapMap Linkage Disequilibrium report
BRE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRE Gene

Disorders for BRE Gene

Relevant External Links for BRE

Genetic Association Database (GAD)
BRE
Human Genome Epidemiology (HuGE) Navigator
BRE
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BRE

No disorders were found for BRE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BRE Gene

Publications for BRE Gene

  1. Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid. (PMID: 7826398) Li L. … Chan J.Y.-H. (Biochem. Biophys. Res. Commun. 1995) 2 3 4 67
  2. Differential expression of a novel gene BRE (TNFRSF1A modulator/BRCC45) in response to stress and biological signals. (PMID: 19757177) Chan J.Y. … Chui Y.L. (Mol. Biol. Rep. 2010) 3 23
  3. A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway. (PMID: 15465831) Li Q. … Chui Y.-L. (J. Biol. Chem. 2004) 3 23
  4. BRE: a modulator of TNF-alpha action. (PMID: 9737713) Gu C. … Chao M.V. (FASEB J. 1998) 2 3
  5. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3

Products for BRE Gene

Sources for BRE Gene

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