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BRE Gene

protein-coding   GIFtS: 58
GCID: GC02P028025

Brain And Reproductive Organ-Expressed (TNFRSF1A Modulator)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Brain And Reproductive Organ-Expressed (TNFRSF1A Modulator)1 2     BRCA1/BRCA2-Containing Complex1
BRCC452 3 5     Subunit 41
Brain And Reproductive Organ-Expressed Protein2 3     BRCA1-A Complex Subunit BRE2
BRCA1/BRCA2-Containing Complex Subunit 452 3     BRCA1/BRCA2-Containing Complex, Subunit 42
BRCC42 5     

External Ids:    HGNC: 11061   Entrez Gene: 95772   Ensembl: ENSG000001580197   OMIM: 6104975   UniProtKB: Q9NXR73   

Export aliases for BRE gene to outside databases

Previous GC identifers: GC02P028034 GC02P028206 GC02P028088 GC02P027855


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for BRE Gene:
BRE (brain and reproductive organ-expressed (TNFRSF1A modulator)) is a protein-coding gene. Diseases associated with BRE include brain glioma, and acute myeloid leukemia. GO annotations related to this gene include tumor necrosis factor receptor binding and peroxisome targeting sequence binding.

UniProtKB/Swiss-Prot: BRE_HUMAN, Q9NXR7
Function: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated
histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage
at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically
removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that
bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex
integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a
role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked
ubiquitin. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline
origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial
apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects
may be indirect

Gene Wiki entry for BRE Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the BRE gene promoter:
         Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): BRE promoter sequence
   Search Chromatin IP Primers for BRE

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BRE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.2   Ensembl cytogenetic band:  2p23.2   HGNC cytogenetic band: 2p23

BRE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRE gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P028025:  view genomic region     (about GC identifiers)

Start:
28,112,808 bp from pter      End:
28,561,768 bp from pter
Size:
448,961 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BRE_HUMAN, Q9NXR7 (See protein sequence)
Recommended Name: BRCA1-A complex subunit BRE  
Size: 383 amino acids; 43552 Da
Subunit: Component of the BRCA1-A complex, at least composed of the BRCA1, BARD1, UIMC1/RAP80, FAM175A/Abraxas,
BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with FAM175A/Abraxas,
BRCC3/BRCC36 and BABAM1/NBA1. Binds polyubiquitin. Component of the BRISC complex, at least composed of the
FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. Component of the BRCA1/BRCA2 containing complex (BRCC),
which also contains BRCA1, BRCA2, BARD1, BRCC3/BRCC36 and RAD51. BRCC is a ubiquitin E3 ligase complex that
enhances cellular survival following DNA damage. May interact with FAS and TNFRSF1A
Secondary accessions: A8K4X1 D6W562 D6W563 Q13880 Q4ZFX8 Q53SD0 Q969X9 Q96P06
Alternative splicing: 4 isoforms:  Q9NXR7-2   Q9NXR7-1   Q9NXR7-3   Q9NXR7-4   

Explore the universe of human proteins at neXtProt for BRE: NX_Q9NXR7

Explore proteomics data for BRE at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys26, Lys41, Lys162
  • Modification sites at PhosphoSitePlus

  • See BRE Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001248769.1  NP_004890.2  NP_954661.1  NP_954662.1  NP_954663.1  NP_954664.1  

    ENSEMBL proteins: 
     ENSP00000392345   ENSP00000343412   ENSP00000368945   ENSP00000339371   ENSP00000368953  
     ENSP00000354699   ENSP00000368950   ENSP00000474342  

    BRE Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for BRE
    OriGene Custom MassSpec
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    Novus Biologicals BRE Proteins
    Novus Biologicals BRE Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BRE

    BRE Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for BRE 
    OriGene Antibodies for BRE
    OriGene Custom Antibody Services for BRE
    Novus Biologicals BRE Antibodies
    Abcam antibodies for BRE
    Cloud-Clone Corp. Antibodies for BRE
    ThermoFisher Antibody for BRE
    LSBio Antibodies in human, mouse, rat for BRE

    BRE Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BRE
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BRE
    Cloud-Clone Corp. CLIAs for BRE


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR010358 Brain/reproduct-express_prot

    Graphical View of Domain Structure for InterPro Entry Q9NXR7

    ProtoNet protein and cluster: Q9NXR7

    UniProtKB/Swiss-Prot: BRE_HUMAN, Q9NXR7
    Domain: Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical
    Cys residues required for ubiquitination but retain the ability to bind ubiquitin
    Similarity: Belongs to the BRE family


    BRE for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BRE_HUMAN, Q9NXR7
    Function: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated
    histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage
    at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically
    removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that
    bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex
    integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a
    role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked
    ubiquitin. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline
    origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial
    apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects
    may be indirect
    Induction: Down-regulated by DNA-damaging agents in fibroblasts, by retinoic acid in brain glioma U-251MG and
    promyelocytic HL-60 cell lines, and by bacterial lipopolysaccharides (LPS) in peripheral blood mononuclear cells
    (PBMC)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000268peroxisome targeting sequence binding TAS11676476
    GO:0005164tumor necrosis factor receptor binding IDA15465831
    GO:0005515protein binding IPI14636569
    GO:0031593polyubiquitin binding IDA19261749
         
    BRE for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for BRE:
     Increased cell death HMECs cel 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Bre):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  other  skeleton 

    BRE for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BRE
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BRE

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BRE
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BRE

    miRNA
    Products:
        
    miRTarBase miRNAs that target BRE:
    hsa-mir-124-3p (MIRT022453)

    Block miRNA regulation of human, mouse, rat BRE using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate BRE:
    hsa-miR-4306 hsa-miR-3138 hsa-miR-3605-5p hsa-miR-1270 hsa-miR-620 hsa-miR-2115 hsa-miR-185 hsa-miR-628-5p
    SwitchGear 3'UTR luciferase reporter plasmidBRE 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BRE
    Predesigned siRNA for gene silencing in human, mouse, rat BRE

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BRE

    Clone
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    OriGene clones in human, mouse for BRE (see all 32)
    OriGene ORF clones in mouse, rat for BRE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BRE (NM_004961)
    Sino Biological Human cDNA Clone for BRE
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BRE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRE

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for BRE 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRE


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BRE_HUMAN, Q9NXR7: Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000152nuclear ubiquitin ligase complex IDA14636569
    GO:0005634nucleus IDA15465831
    GO:0005737cytoplasm IDA15465831
    GO:0070531BRCA1-A complex IDA17525341
    GO:0070552BRISC complex IDA19214193

    BRE for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BRE About    
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    DNA Damage0.32
    2TWEAK Pathway
    Apoptosis and survival TNFR1 signaling pathway0.52
    3Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for BRE
        Cell Cycle / Checkpoint Control
    DNA Damage

    2 GeneGo (Thomson Reuters) Pathways for BRE
        Apoptosis and survival FAS signaling cascades
    Apoptosis and survival TNFR1 signaling pathway




    BRE for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BRE: 
              Apoptosis 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BRE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BRE (Q9NXR71, 2, 3 ENSP000003434124) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BABAM1Q9NWV81, 3, ENSP000003524084EBI-949389,EBI-745725 I2D: score=5 STRING: ENSP00000352408
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2867054 I2D: score=4 STRING: ENSP00000344782
    DHRS7BQ6IAN03, ENSP000003788874I2D: score=2 STRING: ENSP00000378887
    FAM175AQ6UWZ73, ENSP000003698574I2D: score=2 STRING: ENSP00000369857
    FASP254453, ENSP000003479794I2D: score=2 STRING: ENSP00000347979
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006302double-strand break repair IMP19261748
    GO:0006915apoptotic process IEA--
    GO:0006974cellular response to DNA damage stimulus IEP7826398
    GO:0007165signal transduction TAS9737713
    GO:0010212response to ionizing radiation IMP19261748

    BRE for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BRE



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for BRE gene (6 alternative transcripts): 
    NM_001261840.1  NM_004899.4  NM_199191.2  NM_199192.2  NM_199193.2  NM_199194.2  

    Unigene Cluster for BRE:

    Brain and reproductive organ-expressed (TNFRSF1A modulator)
    Hs.258314  [show with all ESTs]
    Unigene Representative Sequence: NM_004899
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000436924 ENST00000344773(uc002rlp.1 uc002rls.3 uc002rlu.3)
    ENST00000379624(uc002rlv.3) ENST00000492702 ENST00000603461 ENST00000496951
    ENST00000342045(uc002rlr.3) ENST00000379632(uc002rlq.3) ENST00000361704(uc002rlt.3)
    ENST00000379629 ENST00000604932
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat BRE using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate BRE:
    hsa-miR-4306 hsa-miR-3138 hsa-miR-3605-5p hsa-miR-1270 hsa-miR-620 hsa-miR-2115 hsa-miR-185 hsa-miR-628-5p
    SwitchGear 3'UTR luciferase reporter plasmidBRE 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for BRE
    Predesigned siRNA for gene silencing in human, mouse, rat BRE
    Clone
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    OriGene clones in human, mouse for BRE (see all 32)
    OriGene ORF clones in mouse, rat for BRE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BRE (NM_004961)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BRE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRE
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for BRE
    OriGene qSTAR qPCR primer pairs in human, mouse for BRE
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BRE
      QuantiTect SYBR Green Assays in human, mouse, rat BRE
      QuantiFast Probe-based Assays in human, mouse, rat BRE

    Additional mRNA sequence: 

    AF015767.1 AF420602.1 AF420603.1 AF420604.1 AF420605.1 AK000097.1 AK098345.1 AK123076.1 
    AK291086.1 AY438031.1 BC001251.1 L38616.1 

    Selected DOTS entries (see all 25):

    DT.101984934  DT.92446387  DT.95146598  DT.91702346  DT.86855482  DT.92446391  DT.100884657  DT.100884638 
    DT.100884642  DT.100884659  DT.454839  DT.95146595  DT.100884660  DT.92446385  DT.100884661  DT.121024320 
    DT.92446388  DT.121024326  DT.92446378  DT.121024164  DT.121024165  DT.121024210  DT.417608  DT.95146574 

    Selected AceView cDNA sequences (see all 90):

    BM717190 AJ404857 BE221723 CD671167 BC014088 CR609030 H82519 BE218181 
    AI912209 AI452781 BE501861 CA434266 BQ016020 NM_022128 AA860865 AI343945 
    AA348964 AI343781 BM675235 BM714050 AL541410 BG201691 AA393609 AI823980 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BRE (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b
    SP1:                                      -                                                                           
    SP2:                                                                                                                  
    SP3:                    -     -                                                                                       
    SP4:                                                                                            -                     
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for BRE

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BRE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGTGTCAGCA
    BRE Expression
    About this image


    BRE expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Eye (Sensory Organs)
             Retina
     
     Thyroid (Endocrine System)
     
     Adrenal Gland (Endocrine System)
     
     Gall Bladder (Hepatobiliary System)
    BRE Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BRE Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.258314

    UniProtKB/Swiss-Prot: BRE_HUMAN, Q9NXR7
    Tissue specificity: Expressed in all cell lines examined. Highly expressed in placenta

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BRE: 
              Apoptosis 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for BRE
    OriGene qSTAR qPCR primer pairs in human, mouse for BRE
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BRE
    QuantiTect SYBR Green Assays in human, mouse, rat BRE
    QuantiFast Probe-based Assays in human, mouse, rat BRE
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for BRE gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bre1 , 5 brain and reproductive organ-expressed protein1, 5 90.25(n)1
    99.22(a)1
      5 (17.27 cM)5
    1079761  NM_144541.11  NP_653124.11 
     316976845 
    chicken
    (Gallus gallus)
    Aves BRE1 brain and reproductive organ-expressed (TNFRSF1A modulator) 82.51(n)
    97.65(a)
      421417  NM_001008458.1  NP_001008458.1 
    lizard
    (Anolis carolinensis)
    Reptilia BRE6
    brain and reproductive organ-expressed (TNFRSF1A m...
    91(a)
    1 ↔ 1
    2(125542024-125729088)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.69072 Xenopus laevis transcribed sequence with moderate similarity more 78.67(n)    BX851153.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570366022   -- 79.92(n)    57036602 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G424701 AT5G42470 44.55(n)
    30.19(a)
      834254  NM_123612.3  NP_199062.2 
    rice
    (Oryza sativa)
    Liliopsida Os06g07156001 Os06g0715600 43.99(n)
    32.59(a)
      4342073  NM_001065121.1  NP_001058586.1 


    ENSEMBL Gene Tree for BRE (if available)
    TreeFam Gene Tree for BRE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BRE (see all 6387)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1869134681,2
    --28116199(+) GTAAGA/GACTTA 6 -- int10--------
    rs124648851,2
    C,H--28116297(+) AAGTAA/GATTTT 6 -- int11Minor allele frequency- G:0.00NA 2
    rs728544181,2
    C,F--28116313(+) TATCTC/ATTCCT 6 -- int14Minor allele frequency- A:0.18WA CSA 124
    rs1396655491,2
    --28116447(+) TGAGTA/GTTTAG 6 -- int10--------
    rs1452041471,2
    C--28116648(+) ATGACA/GTCAAG 6 -- int10--------
    rs1907999281,2
    --28116729(+) GGTGGC/TATGTG 6 -- int10--------
    rs1812712791,2
    --28116778(+) ATCACC/TTGAAC 6 -- int10--------
    rs22194341,2
    C,H--28116870(-) TTTTTT/CTTTTT 6 -- int1 trp33Minor allele frequency- C:0.00NA 8
    rs2015900061,2
    --28116870(+) AAAAA-/GAAAAA 6 -- int10--------
    rs1471700041,2
    --28116904(+) AATAAC/TTTCTA 6 -- int10--------

    HapMap Linkage Disequilibrium report for BRE (28112808 - 28362808 bp, first 250kb of BRE)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for BRE (see all 22):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667473CNV Deletion23128226
    esv3893CNV Deletion18987735
    esv2252743CNV Deletion18987734
    esv2719837CNV Deletion23290073
    esv2470846CNV Deletion19546169
    esv2659295CNV Deletion23128226
    esv271229CNV Insertion20981092
    nsv527688CNV Loss19592680
    nsv873763CNV Loss21882294
    nsv873759CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BRE
    DNA2.0 Custom Variant and Variant Library Synthesis for BRE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610497    OMIM disorders: --

    8 diseases for BRE:    
    About MalaCards
    brain glioma    acute myeloid leukemia    myeloid leukemia    inflammatory bowel disease
    ataxia    esophagitis    hepatocellular carcinoma    leukemia


    BRE for disorders           About GeneDecksing

    Genetic Association Database (GAD): BRE
    Human Genome Epidemiology (HuGE) Navigator: BRE (2 documents)

    Export disorders for BRE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BRE gene, integrated from 10 sources (see all 56):
    (articles sorted by number of sources associating them with BRE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid. (PubMed id 7826398)1, 2, 3 Li L.... Chan J.Y.-H. (Biochem. Biophys. Res. Commun. 1995)
    2. A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway. (PubMed id 15465831)1, 2, 9 Li Q.... Chui Y.-L. (J. Biol. Chem. 2004)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. MERIT40 facilitates BRCA1 localization and DNA damage repair. (PubMed id 19261748)1, 2 Feng L.... Chen J. (Genes Dev. 2009)
    5. MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks. (PubMed id 19261746)1, 2 Shao G.... Greenberg R.A. (Genes Dev. 2009)
    6. NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. (PubMed id 19261749)1, 2 Wang B.... Elledge S.J. (Genes Dev. 2009)
    7. K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC- associated Brcc36 and proteasomal Poh1. (PubMed id 19214193)1, 2 Cooper E.M....Cohen R.E. (EMBO J. 2009)
    8. RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites. (PubMed id 17525341)1, 2 Sobhian B.... Greenberg R.A. (Science 2007)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9577 HGNC: 1106 AceView: RBKS Ensembl:ENSG00000158019 euGenes: HUgn9577
    ECgene: BRE H-InvDB: BRE

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BRE Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BRE Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for BRE gene:
    Search GeneIP for patents involving BRE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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