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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BRE Gene

protein-coding   GIFtS: 57
GCID: GC02P028025

Brain And Reproductive Organ-Expressed (TNFRSF1A Modulator)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Brain And Reproductive Organ-Expressed (TNFRSF1A Modulator)1 2     Subunit 41
Brain And Reproductive Organ-Expressed Protein2 3     BRCC42
BRCC452 3     BRCA1-A Complex Subunit BRE2
BRCA1/BRCA2-Containing Complex Subunit 452 3     BRCA1/BRCA2-Containing Complex, Subunit 42
BRCA1/BRCA2-Containing Complex1     

External Ids:    HGNC: 11061   Entrez Gene: 95772   Ensembl: ENSG000001580197   OMIM: 6104975   UniProtKB: Q9NXR73   

Export aliases for BRE gene to outside databases

Previous GC identifers: GC02P028034 GC02P028206 GC02P028088 GC02P027855


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for BRE Gene: 
BRE (brain and reproductive organ-expressed (TNFRSF1A modulator)) is a protein-coding gene. Diseases associated with BRE include brain glioma, and acute myeloid leukemia, and among its related super-pathways are Cell Cycle / Checkpoint Control and TNFR1 Pathway. GO annotations related to this gene include tumor necrosis factor receptor binding and peroxisome targeting sequence binding.

UniProtKB/Swiss-Prot: BRE_HUMAN, Q9NXR7
Function: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated
histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage
at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically
removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that
bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex
integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a
role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked
ubiquitin. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline
origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial
apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects
may be indirect

Gene Wiki entry for BRE Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BRE gene promoter:
         Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): BRE promoter sequence
   Search SABiosciences Chromatin IP Primers for BRE

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BRE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.2   Ensembl cytogenetic band:  2p23.2   HGNC cytogenetic band: 2p23

BRE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRE gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P028025:  view genomic region     (about GC identifiers)

Start:
28,112,808 bp from pter      End:
28,561,768 bp from pter
Size:
448,961 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BRE_HUMAN, Q9NXR7 (See protein sequence)
Recommended Name: BRCA1-A complex subunit BRE  
Size: 383 amino acids; 43552 Da
Subunit: Component of the BRCA1-A complex, at least composed of the BRCA1, BARD1, UIMC1/RAP80, FAM175A/Abraxas,
BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with FAM175A/Abraxas,
BRCC3/BRCC36 and BABAM1/NBA1. Binds polyubiquitin. Component of the BRISC complex, at least composed of the
FAM175B/ABRO1, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. Component of the BRCA1/BRCA2 containing complex (BRCC),
which also contains BRCA1, BRCA2, BARD1, BRCC3/BRCC36 and RAD51. BRCC is a ubiquitin E3 ligase complex that
enhances cellular survival following DNA damage. May interact with FAS and TNFRSF1A
Subcellular location: Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs)
Secondary accessions: A8K4X1 D6W562 D6W563 Q13880 Q4ZFX8 Q53SD0 Q969X9 Q96P06
Alternative splicing: 4 isoforms:  Q9NXR7-2   Q9NXR7-1   Q9NXR7-3   Q9NXR7-4   

Explore the universe of human proteins at neXtProt for BRE: NX_Q9NXR7

Explore proteomics data for BRE at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NXR7

  • BRE Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BRE Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001248769.1  NP_004890.2  NP_954661.1  NP_954662.1  NP_954663.1  NP_954664.1  

    ENSEMBL proteins: 
     ENSP00000392345   ENSP00000343412   ENSP00000368945   ENSP00000339371   ENSP00000368953  
     ENSP00000354699   ENSP00000368950   ENSP00000474342  

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    OriGene Protein Over-expression Lysate for BRE
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    Novus Biologicals BRE Proteins
    Novus Biologicals BRE Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BRE 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000152nuclear ubiquitin ligase complex IDA14636569
    GO:0005634nucleus IDA15465831
    GO:0005737cytoplasm IDA--
    GO:0070531BRCA1-A complex IDA17525341
    GO:0070552BRISC complex IDA19214193

    BRE for ontologies           About GeneDecksing



    BRE Antibody Products: 
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    Novus Biologicals BRE Antibodies
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    Cloud-Clone Corp. Antibodies for BRE 
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    LSBio Antibodies in human, mouse, rat for BRE 

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    Cloud-Clone Corp. ELISAs for BRE 
    Cloud-Clone Corp. CLIAs for BRE


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR010358 Brain/reproduct-express_prot

    Graphical View of Domain Structure for InterPro Entry Q9NXR7

    ProtoNet protein and cluster: Q9NXR7

    UniProtKB/Swiss-Prot: BRE_HUMAN, Q9NXR7
    Domain: Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical
    Cys residues required for ubiquitination but retain the ability to bind ubiquitin
    Similarity: Belongs to the BRE family


    BRE for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BRE_HUMAN, Q9NXR7
    Function: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated
    histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage
    at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically
    removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that
    bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex
    integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a
    role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked
    ubiquitin. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline
    origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial
    apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects
    may be indirect
    Induction: Down-regulated by DNA-damaging agents in fibroblasts, by retinoic acid in brain glioma U-251MG and
    promyelocytic HL-60 cell lines, and by bacterial lipopolysaccharides (LPS) in peripheral blood mononuclear cells
    (PBMC)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000268peroxisome targeting sequence binding TAS11676476
    GO:0005164tumor necrosis factor receptor binding IDA15465831
    GO:0005515protein binding IPI14636569
    GO:0031593polyubiquitin binding IDA19261749
         
    BRE for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for BRE:
     Increased cell death HMECs cel 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Bre):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  other  skeleton 

    BRE for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for BRE 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BRE

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BRE 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BRE 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BRE
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate BRE:
    hsa-miR-4306 hsa-miR-3138 hsa-miR-3605-5p hsa-miR-1270 hsa-miR-620 hsa-miR-2115 hsa-miR-185 hsa-miR-628-5p
    SwitchGear 3'UTR luciferase reporter plasmidBRE 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: BRE (NM_004961)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BRE
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                         Customized lentivirus expression plasmids for stable overexpression of BRE 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRE


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BRE About                                                                                                See pathways by source

    SuperPathContained pathways About
    1DNA Damage
    DNA Damage0.32
    Cell Cycle / Checkpoint Control0.32
    2TWEAK Pathway
    Apoptosis and survival TNFR1 signaling pathway0.52
    3Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for BRE
        Apoptosis and survival TNFR1 signaling pathway
    Apoptosis and survival FAS signaling cascades


    2 Cell Signaling Technology (CST) Pathways for BRE
        Cell Cycle / Checkpoint Control
    DNA Damage

    2 GeneGo (Thomson Reuters) Pathways for BRE
        Apoptosis and survival FAS signaling cascades
    Apoptosis and survival TNFR1 signaling pathway



    BRE for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BRE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/59 Interacting proteins for BRE (Q9NXR71, 2, 3 ENSP000003434124) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BABAM1Q9NWV81, 3, ENSP000003524084EBI-949389,EBI-745725 I2D: score=5 STRING: ENSP00000352408
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2867054 I2D: score=4 STRING: ENSP00000344782
    DHRS7BQ6IAN03, ENSP000003788874I2D: score=2 STRING: ENSP00000378887
    FAM175AQ6UWZ73, ENSP000003698574I2D: score=2 STRING: ENSP00000369857
    FASP254453, ENSP000003479794I2D: score=2 STRING: ENSP00000347979
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006302double-strand break repair IMP19261748
    GO:0006915apoptotic process IEA--
    GO:0006974response to DNA damage stimulus IEP7826398
    GO:0007165signal transduction TAS9737713
    GO:0010212response to ionizing radiation IMP19261748

    BRE for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BRE

    Search CenterWatch for drugs/clinical trials and news about BRE

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BRE gene (6 alternative transcripts): 
    NM_001261840.1  NM_004899.4  NM_199191.2  NM_199192.2  NM_199193.2  NM_199194.2  

    Unigene Cluster for BRE:

    Brain and reproductive organ-expressed (TNFRSF1A modulator)
    Hs.258314  [show with all ESTs]
    Unigene Representative Sequence: NM_004899
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000436924 ENST00000344773(uc002rlp.1 uc002rls.3 uc002rlu.3)
    ENST00000379624(uc002rlv.3) ENST00000492702 ENST00000603461 ENST00000496951
    ENST00000342045(uc002rlr.3) ENST00000379632(uc002rlq.3) ENST00000361704(uc002rlt.3)
    ENST00000379629 ENST00000604932
    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate BRE:
    hsa-miR-4306 hsa-miR-3138 hsa-miR-3605-5p hsa-miR-1270 hsa-miR-620 hsa-miR-2115 hsa-miR-185 hsa-miR-628-5p
    SwitchGear 3'UTR luciferase reporter plasmidBRE 3' UTR sequence
    Inhib. RNA
    Products:
         
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BRE
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    GenScript: all cDNA clones in your preferred vector: BRE (NM_004961)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BRE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRE
    Sirion Biotech Customized lentivirus for stable overexpression of BRE 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BRE
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BRE

    Additional mRNA sequence: 

    AF015767.1 AF420602.1 AF420603.1 AF420604.1 AF420605.1 AK000097.1 AK098345.1 AK123076.1 
    AK291086.1 AY438031.1 BC001251.1 L38616.1 

    24/25 DOTS entries (see all 25):

    DT.101984934  DT.92446387  DT.95146598  DT.91702346  DT.86855482  DT.92446391  DT.100884657  DT.100884638 
    DT.100884642  DT.100884659  DT.454839  DT.95146595  DT.100884660  DT.92446385  DT.100884661  DT.121024320 
    DT.92446388  DT.121024326  DT.92446378  DT.121024164  DT.121024165  DT.121024210  DT.417608  DT.95146574 

    24/90 AceView cDNA sequences (see all 90):

    AJ404857 CA434266 BQ016020 BM717190 NM_022128 AA860865 AI912209 BE221723 
    CD671167 AI452781 H82519 CR609030 BE501861 BE218181 BC014088 AI669241 
    BG541103 N74761 AW467020 AI343945 AA348964 BG697021 AW080339 CD518288 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for BRE (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b
    SP1:                                      -                                                                           
    SP2:                                                                                                                  
    SP3:                    -     -                                                                                       
    SP4:                                                                                            -                     
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for BRE

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BRE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGTGTCAGCA
    BRE Expression
    About this image


    See BRE Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BRE

    SOURCE GeneReport for Unigene cluster: Hs.258314

    UniProtKB/Swiss-Prot: BRE_HUMAN, Q9NXR7
    Tissue specificity: Expressed in all cell lines examined. Highly expressed in placenta

        SABiosciences Expression via Pathway-Focused PCR Arrays including BRE: 
              Apoptosis 384HT in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BRE
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for BRE gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bre1 , 5 brain and reproductive organ-expressed protein1, 5 90.25(n)1
    99.22(a)1
      5 (17.27 cM)5
    1079761  NM_144541.11  NP_653124.11 
     316976845 
    chicken
    (Gallus gallus)
    Aves BRE1 brain and reproductive organ-expressed (TNFRSF1A modulator) 82.51(n)
    97.65(a)
      421417  NM_001008458.1  NP_001008458.1 
    lizard
    (Anolis carolinensis)
    Reptilia BRE6
    Uncharacterized protein
    91(a)
    1 ↔ 1
    2(125542024-125729088)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.69072 Xenopus laevis transcribed sequence with moderate similarity more 78.67(n)    BX851153.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570366022   -- 79.92(n)    57036602 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G424701 BRCA1-A complex subunit BRE 43.63(n)
    31.94(a)
      834254  NM_123612.3  NP_199062.2 
    rice
    (Oryza sativa)
    Liliopsida Os06g07156001 hypothetical protein 43.99(n)
    32.59(a)
      4342073  NM_001065121.1  NP_001058586.1 


    ENSEMBL Gene Tree for BRE (if available)
    TreeFam Gene Tree for BRE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6387 SNPs in BRE are shown (see all 6387)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1869134681,2
    --28116199(+) GTAAGA/GACTTA 6 -- int10--------
    rs124648851,2
    C,H--28116297(+) AAGTAA/GATTTT 6 -- int11Minor allele frequency- G:0.00NA 2
    rs728544181,2
    C,F--28116313(+) TATCTC/ATTCCT 6 -- int14Minor allele frequency- A:0.18WA CSA 124
    rs1396655491,2
    --28116447(+) TGAGTA/GTTTAG 6 -- int10--------
    rs1452041471,2
    C--28116648(+) ATGACA/GTCAAG 6 -- int10--------
    rs1907999281,2
    --28116729(+) GGTGGC/TATGTG 6 -- int10--------
    rs1812712791,2
    --28116778(+) ATCACC/TTGAAC 6 -- int10--------
    rs22194341,2
    C,H--28116870(-) TTTTTT/CTTTTT 6 -- int1 trp33Minor allele frequency- C:0.00NA 8
    rs2015900061,2
    --28116870(+) AAAAA-/GAAAAA 6 -- int10--------
    rs1471700041,2
    --28116904(+) AATAAC/TTTCTA 6 -- int10--------

    HapMap Linkage Disequilibrium report for BRE (28112808 - 28362808 bp, first 250kb of BRE)

    Structural Variations
         Database of Genomic Variants (DGV) 10/22 variations for BRE (see all 22):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2667473CNV Deletion23128226
    esv3893CNV Deletion18987735
    esv2252743CNV Deletion18987734
    esv2719837CNV Deletion23290073
    esv2470846CNV Deletion19546169
    esv2659295CNV Deletion23128226
    esv271229CNV Insertion20981092
    nsv527688CNV Loss19592680
    nsv873763CNV Loss21882294
    nsv873759CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610497    OMIM disorders: --

    6 diseases for BRE:    About MalaCards
    brain glioma    acute myeloid leukemia    myeloid leukemia    esophagitis
    hepatocellular carcinoma    leukemia


    BRE for disorders           About GeneDecksing

    Genetic Association Database (GAD): BRE
    Human Genome Epidemiology (HuGE) Navigator: BRE (2 documents)

    Export disorders for BRE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BRE gene, integrated from 9 sources (see all 53):
    (articles sorted by number of sources associating them with BRE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid. (PubMed id 7826398)1, 2, 3 Li L.... Chan J.Y.-H. (1995)
    2. A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway. (PubMed id 15465831)1, 2, 9 Li Q.... Chui Y.-L. (2004)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. MERIT40 facilitates BRCA1 localization and DNA damage repair. (PubMed id 19261748)1, 2 Feng L.... Chen J. (2009)
    5. MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks. (PubMed id 19261746)1, 2 Shao G.... Greenberg R.A. (2009)
    6. NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. (PubMed id 19261749)1, 2 Wang B.... Elledge S.J. (2009)
    7. K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC- associated Brcc36 and proteasomal Poh1. (PubMed id 19214193)1, 2 Cooper E.M....Cohen R.E. (2009)
    8. RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites. (PubMed id 17525341)1, 2 Sobhian B.... Greenberg R.A. (2007)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9577 HGNC: 1106 AceView: RBKS Ensembl:ENSG00000158019 euGenes: HUgn9577
    ECgene: BRE H-InvDB: BRE

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BRE Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BRE Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BRE gene:
    Search GeneIP for patents involving BRE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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