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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

BRDT Gene

protein-coding GIFtS: 57
GCID: GC01P092414

bromodomain, testis-specific

Explore 10 diseases affiliated with
BRDT via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Bromodomain, Testis-Specific¹ ²
CT9¹ ² ³
BRD6¹ ²
Cancer/Testis Antigen 9² ³
RING3-Like Protein² ³
Bromodomain Testis-Specific Protein²

External Ids:	HGNC: 1105¹	Entrez Gene: 676²	Ensembl: ENSG00000137948⁷	OMIM: 602144⁵	UniProtKB: Q58F21³

Export aliases for BRDT gene to outside databases

Previous GC identifers: GC01P092874 GC01P091615 GC01P091752 GC01P091886 GC01P092126 GC01P090535

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BRDT:

BRDT is similar to the RING3 protein family. It possesses 2 bromodomain motifs and a PEST sequence (a cluster of

proline, glutamic acid, serine, and threonine residues), characteristic of proteins that undergo rapid intracellular

degradation. The bromodomain is found in proteins that regulate transcription. Several transcript variants encoding

multiple isoforms have been found for this gene. (provided by RefSeq, Jun 2011)

UniProtKB/Swiss-Prot: BRDT_HUMAN, Q58F21

Function: Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8'

(H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes:

plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic

and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of

spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also acts as a

component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR

truncation of specific mRNAs in post-meiotic spermatids. Required for chromocenter organization, a structure comprised

of peri-centromeric heterochromatin

Gene Wiki entry for BRDT

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the BRDT gene promoter:
c-Myb POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BRDT promoter sequence

Search SABiosciences Chromatin IP Primers for BRDT

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BRDT

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.1 Ensembl cytogenetic band: 1p22.1 HGNC cytogenetic band: 1p22.1

BRDT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRDT gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P092414: view genomic region (about GC identifiers)

Start:	92,414,928 bp from pter	End:	92,479,985 bp from pter
Size:	65,058 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BRDT_HUMAN, Q58F21 (See protein sequence)

Recommended Name: Bromodomain testis-specific protein

Size: 947 amino acids; 107954 Da

Subunit: Interacts with mRNA splicing machinery proteins SRSF2, DDX5, HNRNPK and TARDBP. Interacts with the acetylated

N-terminus of histone H1, H2, H3 and H4. Interacts with P-TEFb components CDK9 and CCNT1/cyclin-T1. Interacts with

SMARCE1 (By similarity). Interacts with the acetylated N-terminus of histone H1.4, H2A, H2B, H3 and H4

Subcellular location: Nucleus. Note=Detected on chromatin

Developmental stage: Expressed in embryo testis

Miscellaneous: BRDT is a promising target for male contraception. Inhibition by thienodiazepine inhibitor (+)-JQ1 that

binds Asn-109, prevents recognition of acetylated histone H4, causing a complete and reversible contraceptive effect

in male mice (PubMed:22901802)

Sequence caution: Sequence=AAH05281.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A

sequence; Sequence=AAH47900.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;

Sequence=AAH62700.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;

2 PDB 3D structures from and Proteopedia for BRDT:

2RFJ (3D)

4FLP (3D)

Secondary accessions: A6NF68 B7Z811 B7Z890 B7ZAX7 D3DT32 O14789 Q05DQ4 Q6P5T1 Q7Z4A6 Q8IWI6

Alternative splicing: 5 isoforms: Q58F21-1 Q58F21-2 Q58F21-3 Q58F21-4 Q58F21-5 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BRDT: NX_Q58F21

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q58F21

BRDT Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (7 alternative transcripts):

NP_001229734.1 NP_001229735.1 NP_001229736.1 NP_001229737.1 NP_001229739.1 NP_001717.2 NP_997072.1

ENSEMBL proteins:

ENSP00000354568 ENSP00000359416 ENSP00000396351 ENSP00000416714 ENSP00000408625

ENSP00000400002 ENSP00000400199 ENSP00000410587 ENSP00000404969 ENSP00000414349

ENSP00000447394 ENSP00000446599 ENSP00000408138 ENSP00000384051 ENSP00000387822

ENSP00000378038

Human Recombinant Protein Products for BRDT:

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	Uscn Proteins for BRDT

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	ISS	--

BRDT for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for BRDT

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

BRDT for domains About GeneDecksing

2 InterPro domains/families:

IPR018359 Bromodomain_CS

IPR001487 Bromodomain

Graphical View of Domain Structure for InterPro Entry Q58F21

ProtoNet protein and cluster: Q58F21

1 Blocks protein family: IPB001487 Bromodomain signature

UniProtKB/Swiss-Prot: BRDT_HUMAN, Q58F21

Domain: Bromo domains mediate interaction with histones that have acetylated lysine residues at specific positions

(PubMed:22464331). Bromo domain 1 mediates binding with histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and

H4K8ac, respectively) (PubMed:22901802)

Similarity: Contains 2 bromo domains

Similarity: Contains 1 NET domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: BRDT_HUMAN, Q58F21

Function: Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8'

(H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes:

plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic

and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of

spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also acts as a

component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR

truncation of specific mRNAs in post-meiotic spermatids. Required for chromocenter organization, a structure comprised

of peri-centromeric heterochromatin

Genatlas biochemistry entry for BRDT:

bromodomain testis specific gene,with homology to RING3 (D6S113E) and Drosophila fsh

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003713	transcription coactivator activity	TAS	10365964
GO:0042393	histone binding	IDA	--
GO:0070577	histone acetyl-lysine binding	ISS	--

BRDT for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for BRDT:

Decreased substrate adherent c

2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Brdt):

reproductive system

skeleton

BRDT for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for BRDT

miRNA Products:		OriGene 3'-UTR Clone (see all 2): BRDT Browse MicroRNA Expression Plasmids
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Customized stable knockdown cell line services for BRDT Sirion Biotech Customized inducible knockdown cell line services for BRDT Sirion Biotech Customized stable overexpressing cell line services for BRDT Sirion Biotech Customized inducible overexpressing cell line services for BRDT

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRDT

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for BRDT

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

5/15 Interacting proteins for BRDT (Q58F21³ ENSP00000354568⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 15)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³, ENSP00000352980⁴	I2D: score=2 STRING: ENSP00000352980
HIST1H4B	P62805³	I2D: score=2
HIST1H4C	P62805³	I2D: score=2
HIST1H4D	P62805³	I2D: score=2
HIST1H4E	P62805³	I2D: score=2

About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001207	histone displacement	ISS	--
GO:0006338	chromatin remodeling	ISS	--
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0006397	mRNA processing	IEA	--

BRDT for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for BRDT
Search CenterWatch for drugs/clinical trials and news about BRDT

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for BRDT gene (7 alternative transcripts):

NM_001242805.1 NM_001242806.1 NM_001242807.1 NM_001242808.1 NM_001242810.1 NM_001726.3 NM_207189.2

Unigene Cluster for BRDT:

Bromodomain, testis-specific

Hs.482520 [show with all ESTs]

Unigene Representative Sequence: NM_001242810

18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):

ENST00000362005(uc001dol.4) ENST00000370389(uc009wdf.3) ENST00000423434

ENST00000440509 ENST00000461218 ENST00000470955 ENST00000476711 ENST00000449584

ENST00000427104 ENST00000355011 ENST00000448194 ENST00000426141 ENST00000484833

ENST00000450792 ENST00000548992 ENST00000552654 ENST00000457265 ENST00000402388(uc001dom.4)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): BRDT Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BRDT
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AF019085.1 AK302758.1 AK303008.1 AK316442.1 AY338951.1 BC005281.1 BC017582.1 BC028126.2

BC038844.2 BC047900.1 BC062700.1 BX648135.1

10 DOTS entries:

DT.91993808 DT.101983314 DT.208142 DT.95126784 DT.100776947 DT.101983312 DT.100776949 DT.121364206

DT.92041476 DT.100776950

24/60 AceView cDNA sequences (see all 60):

AI655872 BC047900 AI983123 CD360012 NM_207189 NM_001726 BX648135 CD359563

BC038844 BC028126 CO370599 BI829963 BP370315 BG150293 AA884041 BU570441

BC017582 BP369544 AI656466 AW197550 BP370427 BI830253 BP371293 BM552817

GeneLoc Exon Structure

5/15 Alternative Splicing Database (ASD) splice patterns (SP) for BRDT (see all 15) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3a	·	3b	·	3c	·	3d	·	3e	^	4	^	5	^	6	^	7a	·	7b	·	7c	^	8	^	9a	·	9b	·	9c	^	10a	·	10b	·	10c	·	10d	^	11	^	12	^
SP1:											-		-		-		-		-		-												-														-
SP2:							-				-		-		-		-		-		-												-
SP3:					-		-				-		-		-		-		-		-
SP4:																																	-
SP5:					-		-		-		-		-		-		-		-		-

ExUns:	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for BRDT

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

BRDT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAAAGTTTA

About this image

BRDT expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Intermediate limb mesenchymal cells (ILM cells) (Primary Cell)

Bone, Cartilage, Limb

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See BRDT Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BRDT

SOURCE GeneReport for Unigene cluster: Hs.482520

UniProtKB/Swiss-Prot: BRDT_HUMAN, Q58F21

Tissue specificity: Testis-specific. A 3-fold higher expression is seen in adult testis than in embryo testis.

Expression seems to be correlated with histone H4 hyperacetylation during the haploid phase of spermatogenesis

(spermiogenesis). No expression, or very low expression is seen in patients' testes with abnormal spermatogenesis.

Expressed in cancers such as non-small cell lung cancer and squamous cell carcinomas of the head and neck as well as

of esophagus, but not in melanoma or in cancers of the colon, breast, kidney and bladder

SABiosciences Expression via Pathway-Focused PCR Array including BRDT:

Epigenetic Chromatin Remodeling Factors in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for BRDT gene from 8/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	BRDT¹	bromodomain, testis-specific	60.85(n) 50.49(a)		424506 XM_003641723.1 XP_003641771.1
lizard (Anolis carolinensis)	Reptilia	BRDT⁶	--	47(a)	1 ↔ 1	4(94020666-94055427)
African clawed frog (Xenopus laevis)	Amphibia	BC060452.1²	--	76.65(n)		BC060452.1
zebrafish (Danio rerio)	Actinopterygii	brdt⁶	bromodomain, testis-specific	34(a)	1 ↔ 1	6(20576975-20605212)
fruit fly (Drosophila melanogaster)	Insecta	fs(1)h³	regulation of transcription from Pol II promoter more	47(a)		--
worm (Caenorhabditis elegans)	Secernentea	bet-2⁶ bet-1⁶	Protein BET-2, isoform a Temporarily Assigned Gene name family member (tag-...	9(a) 13(a)	possible ortholog possible ortholog	X(10569057-10575659) I(4526379-4534801)
thale cress (Arabidopsis thaliana)	eudicotyledons	NPX1⁶ GTE3⁶ (see all 12)	bromodomain-containing protein GTE3 (see all 12)	8(a) 21(a) (see all 12)	possible ortholog many ↔ many (see all 12)	5(25374413-25379297) 1(27504112-27506112)
rice (Oryza sativa)	Liliopsida	-- -- (see all 11)	bromodomain domain containing protein, expressed (see all 11)	7(a) 27(a) (see all 11)	possible ortholog possible ortholog (see all 11)	8(1566556-1572065) 1(26172141-26176186)

ENSEMBL Gene Tree for BRDT (if available)
TreeFam Gene Tree for BRDT (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for BRDT gene

BRD4² CREBBP² BRD2² EP300² BRD3²

17 SIMAP similar genes for BRDT using alignment to 11 protein entries: BRDT_HUMAN (see all proteins):

BRD3 DKFZp686N0336 BRD2 BRD4 DKFZp313H139 BAZ1A

BPTF CREBBP BAZ2A TAF1 BAZ2B DYT3

N-TAF1 TRIM33 BRD1 EP300 CECR2

BRDT for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for BRDT
PGOHUM00000241455

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs114839459^1,2		--	92412978(+)	`CTTCAG/TCCTGA`	6	--	us2k¹		1		NA	120
rs192277833^1,2		--	92413007(+)	`GGGATC/TGGAGG`	6	--	us2k¹		0	--	--	--	--
rs182670754^1,2		--	92413125(+)	`AGCTGA/GAGGCA`	6	--	us2k¹		0	--	--	--	--
rs186723740^1,2		--	92413179(+)	`TAAAAA/GTAATG`	6	--	us2k¹		0	--	--	--	--
rs191280673^1,2		--	92413323(+)	`CCTCCC/TAGGTT`	6	--	us2k¹		0	--	--	--	--
rs182746873^1,2		--	92413335(+)	`AAGCGA/GTGCTC`	6	--	us2k¹		0	--	--	--	--
rs112624078^1,2	C,F	--	92413377(+)	`AGACCC/TGTGCC`	6	--	us2k¹		2		WA CSA	4
rs61779127^1,2	C	--	92413423(+)	`ACAGGA/GTTTCA`	6	--	us2k¹		0	--	--	--	--
rs187024375^1,2		--	92413494(+)	`CCCCCA/TGCCTC`	6	--	us2k¹		0	--	--	--	--
rs148367624^1,2		--	92413517(+)	`GATTAC/GAGGCA`	6	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for BRDT (92414928 - 92479985 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for BRDT
1 CNV: 8323

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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BRDT for disorders           About GeneDecksing

OMIM gene information: 602144    OMIM disorders: --

10 diseases for BRDT:    About MalaCards

squamous cell carcinoma of the head and neck squamous cell carcinoma esophagus melanoma stomatitis

azoospermia melanoma lung cancer carcinoma

pancreatic cancer pancreatitis

Human Genome Epidemiology (HuGE) Navigator: BRDT (2 documents)

Export disorders for BRDT gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for BRDT gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with BRDT)

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Identification and characterization of BRDT: a testis-specific gene related to the bromodomain genes RING3 and Drosophila fsh. (PubMed id 9367677)^{1, 2, 3, 9} Jones M.H.... Shimane M. (1997)
Expression of cancer-testis antigens in lung cancer: definition of bromodomain testis-specific gene (BRDT) as a new CT gene, CT9. (PubMed id 10704737)^{1, 2, 9} Scanlan M.J.... Old L.J. (2000)
Molecular cloning and expression of a novel alternative splice variant of BRDT gene. (PubMed id 15647849)^{1, 2, 9} Zheng Y.... Sha J.-H. (2005)
The interaction of modified histones with the bromodo main testis-specific (BRDT) gene and its mRNA level in sperm of fertile donors and subfertile men. (PubMed id 20538714)^{1, 2} Steilmann C....Paradowska A. (2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Small-molecule inhibition of BRDT for male contraception. (PubMed id 22901802)² Matzuk M.M....Bradner J.E. (2012)
The conserved 12-amino acid stretch in the inter-bromodomain region of BET family proteins functions as a nuclear localization signal. (PubMed id 22971749)² Fukazawa H. and Masumi A. (2012)
Histone recognition and large-scale structural analysis of the human bromodomain family. (PubMed id 22464331)² Filippakopoulos P.... Knapp S. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Expression of BET genes in testis of men with differe nt spermatogenic impairments. (PubMed id 22035730)¹ Barda S....Kleiman S.E. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 676	HGNC: 1105	AceView: BRDT	Ensembl:ENSG00000137948	euGenes: HUgn676
ECgene: BRDT	H-InvDB: BRDT

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for BRDT	Pharmacogenomics, SNPs, Pathways
Protein Spotlight	http://web.expasy.org/spotlight/back_issues/sptlt144.shtml

Intellectual Property for BRDT gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for BRDT gene:
Search GeneIP for patents involving BRDT

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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bromodomain, testis-specific

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