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Aliases for BRD9 Gene

Aliases for BRD9 Gene

  • Bromodomain Containing 9 2 3
  • Rhabdomyosarcoma Antigen MU-RMS-40.8 3 4
  • Bromodomain-Containing Protein 9 3
  • Sarcoma Antigen NY-SAR-29 3
  • LAVS3040 3
  • PRO9856 3

External Ids for BRD9 Gene

Summaries for BRD9 Gene

GeneCards Summary for BRD9 Gene

BRD9 (Bromodomain Containing 9) is a Protein Coding gene. Diseases associated with BRD9 include rhabdomyosarcoma and shipyard eye. GO annotations related to this gene include nucleic acid binding and lysine-acetylated histone binding. An important paralog of this gene is BRD7.

UniProtKB/Swiss-Prot for BRD9 Gene

  • May play a role in chromatin remodeling and regulation of transcription

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRD9 Gene

Genomics for BRD9 Gene

Genomic Location for BRD9 Gene

Start:
850,291 bp from pter
End:
892,824 bp from pter
Size:
42,534 bases
Orientation:
Minus strand

Genomic View for BRD9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BRD9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRD9 Gene

Regulatory Elements for BRD9 Gene

Proteins for BRD9 Gene

  • Protein details for BRD9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8M2-BRD9_HUMAN
    Recommended name:
    Bromodomain-containing protein 9
    Protein Accession:
    Q9H8M2
    Secondary Accessions:
    • A6NFY8
    • B4DMQ2
    • B4DR93
    • Q2XUS1
    • Q6UWU9
    • Q8IUS4
    • Q9H5Q5
    • Q9H7R9

    Protein attributes for BRD9 Gene

    Size:
    597 amino acids
    Molecular mass:
    67000 Da
    Quaternary structure:
    • Binds acetylated histone H3 (in vitro).
    SequenceCaution:
    • Sequence=BAB15565.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BRD9 Gene

    Alternative splice isoforms for BRD9 Gene

neXtProt entry for BRD9 Gene

Proteomics data for BRD9 Gene at MOPED

Post-translational modifications for BRD9 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys277

No data available for DME Specific Peptides for BRD9 Gene

Domains for BRD9 Gene

Protein Domains for BRD9 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

BRD9_HUMAN
Domain:
  • Bromo domains mediate interaction with histones that have acetylated lysine residues at specific positions.:
    • Q9H8M2
  • Contains 1 bromo domain.:
    • Q9H8M2
genes like me logo Genes that share domains with BRD9: view

No data available for Gene Families for BRD9 Gene

Function for BRD9 Gene

Molecular function for BRD9 Gene

UniProtKB/Swiss-Prot Function: May play a role in chromatin remodeling and regulation of transcription

Gene Ontology (GO) - Molecular Function for BRD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding NAS 18559093
GO:0005515 protein binding IPI 25416956
GO:0070577 lysine-acetylated histone binding IDA 22464331
genes like me logo Genes that share ontologies with BRD9: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BRD9 Gene

Localization for BRD9 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BRD9 Gene COMPARTMENTS Subcellular localization image for BRD9 gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for BRD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with BRD9: view

Pathways for BRD9 Gene

SuperPathways for BRD9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BRD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
GO:0016568 chromatin modification IEA --
genes like me logo Genes that share ontologies with BRD9: view

No data available for Pathways by source for BRD9 Gene

Transcripts for BRD9 Gene

Unigene Clusters for BRD9 Gene

Bromodomain containing 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BRD9 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^
SP1: - - - - -
SP2: - -
SP3: - - - -
SP4: - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - - -
SP8: - - -
SP9:
SP10:
SP11: - - -
SP12: - - - - -
SP13:
SP14: -
SP15: -
SP16: - - - - - -
SP17:
SP18:
SP19: - - -
SP20: -
SP21:

ExUns: 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b ^ 22 ^ 23a · 23b · 23c ^ 24a · 24b ^ 25
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9: - - - -
SP10: - - -
SP11:
SP12:
SP13: - -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:

Relevant External Links for BRD9 Gene

GeneLoc Exon Structure for
BRD9
ECgene alternative splicing isoforms for
BRD9

Expression for BRD9 Gene

mRNA expression in normal human tissues for BRD9 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BRD9 Gene

SOURCE GeneReport for Unigene cluster for BRD9 Gene Hs.449278

genes like me logo Genes that share expressions with BRD9: view

Orthologs for BRD9 Gene

This gene was present in the common ancestor of animals.

Orthologs for BRD9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BRD9 36
  • 97.04 (n)
  • 96.63 (a)
BRD9 37
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BRD9 36
  • 85.66 (n)
  • 91.43 (a)
BRD9 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BRD9 36
  • 89.06 (n)
  • 92.99 (a)
BRD9 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Brd9 36
  • 84.76 (n)
  • 92.13 (a)
Brd9 16
Brd9 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BRD9 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BRD9 37
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Brd9 36
  • 85 (n)
  • 92.87 (a)
chicken
(Gallus gallus)
Aves BRD9 36
  • 76.26 (n)
  • 85.62 (a)
BRD9 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BRD9 37
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia brd9 36
  • 68.89 (n)
  • 74.74 (a)
zebrafish
(Danio rerio)
Actinopterygii brd9 36
  • 71.07 (n)
  • 73.22 (a)
brd9 37
  • 67 (a)
OneToOne
zgc55797 36
fruit fly
(Drosophila melanogaster)
Insecta CG7154 37
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea swsn-9 37
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 31 (a)
OneToMany
Species with no ortholog for BRD9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BRD9 Gene

ENSEMBL:
Gene Tree for BRD9 (if available)
TreeFam:
Gene Tree for BRD9 (if available)

Paralogs for BRD9 Gene

Paralogs for BRD9 Gene

Selected SIMAP similar genes for BRD9 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for BRD9 Gene

genes like me logo Genes that share paralogs with BRD9: view

Variants for BRD9 Gene

Sequence variations from dbSNP and Humsavar for BRD9 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs508016 -- 878,410(-) ACGAG(A/T)TGGAG reference, missense, nc-transcript-variant
rs515702 -- 874,759(-) TCACT(G/T)ATGAT intron-variant
rs576341 -- 872,738(-) tccct(A/C/T)gaagg intron-variant
rs586343 -- 882,222(-) CTGTA(C/G)TTCTT intron-variant
rs600228 -- 874,542(+) CGTGC(A/C)CAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BRD9 Gene

Variant ID Type Subtype PubMed ID
nsv881103 CNV Gain 21882294
dgv1735e1 CNV Complex 17122850
dgv1736e1 CNV Complex 17122850
nsv428459 CNV Gain+Loss 18775914
dgv5895n71 CNV Gain 21882294
nsv10654 CNV Gain+Loss 18304495
dgv1740e1 CNV Complex 17122850
dgv198e55 CNV Gain 17911159
nsv880898 CNV Loss 21882294
dgv1744e1 CNV Complex 17122850
nsv509043 CNV Insertion 20534489
nsv880488 CNV Gain 21882294
essv4334 CNV CNV 17122850
dgv957e201 CNV Deletion 23290073
dgv1746e1 CNV Complex 17122850
nsv519464 CNV Loss 19592680
nsv818308 CNV Gain 17921354
nsv441936 CNV CNV 18776908
esv33837 CNV Gain 17666407
nsv830186 CNV Gain 17160897
nsv881057 CNV Loss 21882294
esv22775 CNV Gain 19812545
nsv822952 CNV Gain 20364138

Relevant External Links for BRD9 Gene

HapMap Linkage Disequilibrium report
BRD9

Disorders for BRD9 Gene

(1) University of Copenhagen DISEASES for BRD9 Gene

Relevant External Links for BRD9

Genetic Association Database (GAD)
BRD9
Human Genome Epidemiology (HuGE) Navigator
BRD9
genes like me logo Genes that share disorders with BRD9: view

No data available for UniProtKB/Swiss-Prot for BRD9 Gene

Publications for BRD9 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for BRD9 Gene

  • Addgene plasmids for BRD9

Sources for BRD9 Gene

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