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Aliases for BRD9 Gene

Aliases for BRD9 Gene

  • Bromodomain Containing 9 2 3 5
  • Rhabdomyosarcoma Antigen MU-RMS-40.8 3 4
  • Sarcoma Antigen NY-SAR-29 3
  • LAVS3040 3
  • PRO9856 3

External Ids for BRD9 Gene

Previous GeneCards Identifiers for BRD9 Gene

  • GC05M000916

Summaries for BRD9 Gene

GeneCards Summary for BRD9 Gene

BRD9 (Bromodomain Containing 9) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and lysine-acetylated histone binding. An important paralog of this gene is BRD7.

UniProtKB/Swiss-Prot for BRD9 Gene

  • May play a role in chromatin remodeling and regulation of transcription.

Tocris Summary for BRD9 Gene

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRD9 Gene

Genomics for BRD9 Gene

Regulatory Elements for BRD9 Gene

Promoters for BRD9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BRD9 on UCSC Golden Path with GeneCards custom track

Genomic Location for BRD9 Gene

Chromosome:
5
Start:
850,291 bp from pter
End:
892,824 bp from pter
Size:
42,534 bases
Orientation:
Minus strand

Genomic View for BRD9 Gene

Genes around BRD9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRD9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRD9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRD9 Gene

Proteins for BRD9 Gene

  • Protein details for BRD9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8M2-BRD9_HUMAN
    Recommended name:
    Bromodomain-containing protein 9
    Protein Accession:
    Q9H8M2
    Secondary Accessions:
    • A6NFY8
    • B4DMQ2
    • B4DR93
    • Q2XUS1
    • Q6UWU9
    • Q8IUS4
    • Q9H5Q5
    • Q9H7R9

    Protein attributes for BRD9 Gene

    Size:
    597 amino acids
    Molecular mass:
    67000 Da
    Quaternary structure:
    • Binds acetylated histone H3 (in vitro).
    SequenceCaution:
    • Sequence=BAB15565.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BRD9 Gene

    Alternative splice isoforms for BRD9 Gene

neXtProt entry for BRD9 Gene

Proteomics data for BRD9 Gene at MOPED

Post-translational modifications for BRD9 Gene

  • Ubiquitination at Lys 277
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for BRD9

No data available for DME Specific Peptides for BRD9 Gene

Domains & Families for BRD9 Gene

Protein Domains for BRD9 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9H8M2

UniProtKB/Swiss-Prot:

BRD9_HUMAN :
  • Bromo domains mediate interaction with histones that have acetylated lysine residues at specific positions.
Domain:
  • Bromo domains mediate interaction with histones that have acetylated lysine residues at specific positions.
  • Contains 1 bromo domain.
genes like me logo Genes that share domains with BRD9: view

No data available for Gene Families for BRD9 Gene

Function for BRD9 Gene

Molecular function for BRD9 Gene

UniProtKB/Swiss-Prot Function:
May play a role in chromatin remodeling and regulation of transcription.

Gene Ontology (GO) - Molecular Function for BRD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding NAS 18559093
GO:0005515 protein binding IEA,IPI 25416956
genes like me logo Genes that share ontologies with BRD9: view
genes like me logo Genes that share phenotypes with BRD9: view

Animal Model Products

miRNA for BRD9 Gene

miRTarBase miRNAs that target BRD9

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BRD9 Gene

Localization for BRD9 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BRD9 Gene COMPARTMENTS Subcellular localization image for BRD9 gene
Compartment Confidence
nucleus 3
extracellular 2
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for BRD9 Gene

Pathways & Interactions for BRD9 Gene

SuperPathways for BRD9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BRD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with BRD9: view

No data available for Pathways by source and SIGNOR curated interactions for BRD9 Gene

Drugs & Compounds for BRD9 Gene

No Compound Related Data Available

Transcripts for BRD9 Gene

Unigene Clusters for BRD9 Gene

Bromodomain containing 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BRD9 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^
SP1: - - - - -
SP2: - -
SP3: - - - -
SP4: - - - -
SP5: - - - - - - -
SP6: - - - -
SP7: - - -
SP8: - - -
SP9:
SP10:
SP11: - - -
SP12: - - - - -
SP13:
SP14: -
SP15: -
SP16: - - - - - -
SP17:
SP18:
SP19: - - -
SP20: -
SP21:

ExUns: 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b ^ 22 ^ 23a · 23b · 23c ^ 24a · 24b ^ 25
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9: - - - -
SP10: - - -
SP11:
SP12:
SP13: - -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:

Relevant External Links for BRD9 Gene

GeneLoc Exon Structure for
BRD9
ECgene alternative splicing isoforms for
BRD9

Expression for BRD9 Gene

mRNA expression in normal human tissues for BRD9 Gene

Protein differential expression in normal tissues from HIPED for BRD9 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (57.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BRD9 Gene



SOURCE GeneReport for Unigene cluster for BRD9 Gene Hs.449278

genes like me logo Genes that share expression patterns with BRD9: view

Protein tissue co-expression partners for BRD9 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BRD9 Gene

Orthologs for BRD9 Gene

This gene was present in the common ancestor of animals.

Orthologs for BRD9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BRD9 35
  • 97.04 (n)
  • 96.63 (a)
BRD9 36
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BRD9 36
  • 89 (a)
OneToOne
BRD9 35
  • 85.66 (n)
  • 91.43 (a)
dog
(Canis familiaris)
Mammalia BRD9 35
  • 89.06 (n)
  • 92.99 (a)
BRD9 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Brd9 16
Brd9 35
  • 84.76 (n)
  • 92.13 (a)
Brd9 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BRD9 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BRD9 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Brd9 35
  • 85 (n)
  • 92.87 (a)
chicken
(Gallus gallus)
Aves BRD9 35
  • 76.26 (n)
  • 85.62 (a)
BRD9 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BRD9 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia brd9 35
  • 68.89 (n)
  • 74.74 (a)
zebrafish
(Danio rerio)
Actinopterygii brd9 36
  • 67 (a)
OneToOne
brd9 35
  • 71.07 (n)
  • 73.22 (a)
zgc55797 35
fruit fly
(Drosophila melanogaster)
Insecta CG7154 36
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea swsn-9 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToMany
Species with no ortholog for BRD9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BRD9 Gene

ENSEMBL:
Gene Tree for BRD9 (if available)
TreeFam:
Gene Tree for BRD9 (if available)

Paralogs for BRD9 Gene

Paralogs for BRD9 Gene

(2) SIMAP similar genes for BRD9 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for BRD9 Gene

genes like me logo Genes that share paralogs with BRD9: view

Variants for BRD9 Gene

Sequence variations from dbSNP and Humsavar for BRD9 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs34292369 -, - 886,629(-) AAACT(A/G)CCAAG nc-transcript-variant, reference, missense
VAR_033636 -
rs508016 -- 878,410(-) ACGAG(A/T)TGGAG nc-transcript-variant, downstream-variant-500B, reference, missense
rs515702 -- 874,759(-) TCACT(G/T)ATGAT intron-variant
rs576341 -- 872,738(-) tccct(A/C/T)gaagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BRD9 Gene

Variant ID Type Subtype PubMed ID
nsv881103 CNV Gain 21882294
dgv1735e1 CNV Complex 17122850
dgv1736e1 CNV Complex 17122850
nsv428459 CNV Gain+Loss 18775914
dgv5895n71 CNV Gain 21882294
nsv10654 CNV Gain+Loss 18304495
dgv1740e1 CNV Complex 17122850
dgv198e55 CNV Gain 17911159
nsv880898 CNV Loss 21882294
dgv1744e1 CNV Complex 17122850
nsv509043 CNV Insertion 20534489
nsv880488 CNV Gain 21882294
essv4334 CNV CNV 17122850
dgv957e201 CNV Deletion 23290073
dgv1746e1 CNV Complex 17122850
nsv519464 CNV Loss 19592680
nsv818308 CNV Gain 17921354
nsv441936 CNV CNV 18776908
esv33837 CNV Gain 17666407
nsv830186 CNV Gain 17160897
nsv881057 CNV Loss 21882294
esv22775 CNV Gain 19812545
nsv822952 CNV Gain 20364138

Variation tolerance for BRD9 Gene

Residual Variation Intolerance Score: 9.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.65; 56.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BRD9 Gene

HapMap Linkage Disequilibrium report
BRD9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRD9 Gene

Disorders for BRD9 Gene

Relevant External Links for BRD9

Genetic Association Database (GAD)
BRD9
Human Genome Epidemiology (HuGE) Navigator
BRD9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BRD9

No disorders were found for BRD9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BRD9 Gene

Publications for BRD9 Gene

  1. Histone recognition and large-scale structural analysis of the human bromodomain family. (PMID: 22464331) Filippakopoulos P. … Knapp S. (Cell 2012) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. (PMID: 25086665) Wolpin B.M. … Amundadottir L.T. (Nat. Genet. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for BRD9 Gene

Sources for BRD9 Gene

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