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Aliases for BRD8 Gene

Aliases for BRD8 Gene

  • Bromodomain Containing 8 2 3
  • Thyroid Hormone Receptor Coactivating Protein Of 120 KDa 3 4
  • Skeletal Muscle Abundant Protein 2 3 4
  • TrCP120 3 4
  • SMAP2 3 4
  • P120 3 4
  • SMAP 3 4
  • Bromodomain-Containing Protein 8 3
  • Skeletal Muscle Abundant Protein 4

External Ids for BRD8 Gene

Previous GeneCards Identifiers for BRD8 Gene

  • GC05M137506
  • GC05M137551
  • GC05M137503
  • GC05M137475
  • GC05M132666

Summaries for BRD8 Gene

Entrez Gene Summary for BRD8 Gene

  • The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Multiple alternatively spliced transcript variants that encode distinct isoforms have been identified. [provided by RefSeq, Jul 2014]

GeneCards Summary for BRD8 Gene

BRD8 (Bromodomain Containing 8) is a Protein Coding gene. Among its related pathways are Endocytosis and RNA Polymerase I Promoter Opening. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and thyroid hormone receptor activity.

UniProtKB/Swiss-Prot for BRD8 Gene

  • May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.

Gene Wiki entry for BRD8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRD8 Gene

Genomics for BRD8 Gene

Regulatory Elements for BRD8 Gene

Genomic Location for BRD8 Gene

Start:
138,139,766 bp from pter
End:
138,178,986 bp from pter
Size:
39,221 bases
Orientation:
Minus strand

Genomic View for BRD8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BRD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRD8 Gene

Proteins for BRD8 Gene

  • Protein details for BRD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0E9-BRD8_HUMAN
    Recommended name:
    Bromodomain-containing protein 8
    Protein Accession:
    Q9H0E9
    Secondary Accessions:
    • O43178
    • Q15355
    • Q58AB0
    • Q59GN0
    • Q969M9

    Protein attributes for BRD8 Gene

    Size:
    1235 amino acids
    Molecular mass:
    135336 Da
    Quaternary structure:
    • Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. BRD8 isoform 2 interacts with RXRA/NR2B1 and THRB/ERBA2 (By similarity). Component of a SWR1-like complex.
    SequenceCaution:
    • Sequence=AAB87858.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH08039.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH08076.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA63925.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for BRD8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BRD8 Gene

Proteomics data for BRD8 Gene at MOPED

Post-translational modifications for BRD8 Gene

No Post-translational modifications

Antibody Products

No data available for DME Specific Peptides for BRD8 Gene

Domains for BRD8 Gene

Protein Domains for BRD8 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for BRD8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0E9

UniProtKB/Swiss-Prot:

BRD8_HUMAN :
  • Q9H0E9
Domain:
  • Contains 2 bromo domains.
genes like me logo Genes that share domains with BRD8: view

No data available for Gene Families for BRD8 Gene

Function for BRD8 Gene

Molecular function for BRD8 Gene

UniProtKB/Swiss-Prot Function:
May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.

Gene Ontology (GO) - Molecular Function for BRD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 8611617
GO:0004887 thyroid hormone receptor activity TAS 9368056
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with BRD8: view

Phenotypes for BRD8 Gene

MGI mutant phenotypes for BRD8:
inferred from 1 alleles
GenomeRNAi human phenotypes for BRD8:
genes like me logo Genes that share phenotypes with BRD8: view

Animal Model Products

miRNA for BRD8 Gene

miRTarBase miRNAs that target BRD8

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for BRD8 Gene

Localization for BRD8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRD8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BRD8 Gene COMPARTMENTS Subcellular localization image for BRD8 gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 1
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for BRD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000812 Swr1 complex IDA 24463511
GO:0005634 nucleus NAS 8611617
GO:0005654 nucleoplasm TAS --
GO:0005739 mitochondrion IDA --
GO:0035267 NuA4 histone acetyltransferase complex IDA 14966270
genes like me logo Genes that share ontologies with BRD8: view

Pathways for BRD8 Gene

genes like me logo Genes that share pathways with BRD8: view

Pathways by source for BRD8 Gene

1 KEGG pathway for BRD8 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for BRD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 8611617
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 9368056
GO:0007165 signal transduction TAS 9368056
genes like me logo Genes that share ontologies with BRD8: view

Compounds for BRD8 Gene

(6) ApexBio Compounds for BRD8 Gene

Compound Action Cas Number
CPI-203 BET bromodomain inhibitor [1446144-04-2]
I-BET151 (GSK1210151A) Selective BET inhibitor [1300031-49-5]
MS436 BRD4 inhibitor [1395084-25-9]
OF-1 BRPF1B and BRPF2 bromodomain inhibitor [919973-83-4]
PFI-1 (PF-6405761) BET inhibitor [1403764-72-6]
UNC1215 Chemical probe for the methyllysine (Kme) [1415800-43-9]

(1) Novoseek inferred chemical compound relationships for BRD8 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 21.1 5
genes like me logo Genes that share compounds with BRD8: view

Transcripts for BRD8 Gene

Unigene Clusters for BRD8 Gene

Bromodomain containing 8:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BRD8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BRD8 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5:
SP6:
SP7: -
SP8: -
SP9:
SP10:
SP11:
SP12: - - - - - - - - - - -

ExUns: 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26a · 26b · 26c · 26d ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32a · 32b ^ 33
SP1: - -
SP2: - - -
SP3: - - -
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9: -
SP10: - - - - - - -
SP11:
SP12: - - - -

Relevant External Links for BRD8 Gene

GeneLoc Exon Structure for
BRD8
ECgene alternative splicing isoforms for
BRD8

Expression for BRD8 Gene

mRNA expression in normal human tissues for BRD8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for BRD8 Gene

This gene is overexpressed in Testis (21.6) and Peripheral blood mononuclear cells (14.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BRD8 Gene

SOURCE GeneReport for Unigene cluster for BRD8 Gene Hs.519337

mRNA Expression by UniProt/SwissProt for BRD8 Gene

Q9H0E9-BRD8_HUMAN
Tissue specificity: Expressed in adipose tissue, brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.
genes like me logo Genes that share expressions with BRD8: view

Expression partners for BRD8 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for BRD8 Gene

Orthologs for BRD8 Gene

This gene was present in the common ancestor of animals.

Orthologs for BRD8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BRD8 35
  • 93.63 (n)
  • 95.71 (a)
BRD8 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BRD8 35
  • 93.32 (n)
  • 96.52 (a)
BRD8 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Brd8 35
  • 90.42 (n)
  • 94.44 (a)
Brd8 16
Brd8 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BRD8 35
  • 99.68 (n)
  • 99.6 (a)
BRD8 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Brd8 35
  • 89.33 (n)
  • 93.53 (a)
oppossum
(Monodelphis domestica)
Mammalia BRD8 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BRD8 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves BRD8 35
  • 75.34 (n)
  • 78.38 (a)
BRD8 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BRD8 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia brd8 35
  • 69.79 (n)
  • 72.04 (a)
Str.15923 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15498 35
zebrafish
(Danio rerio)
Actinopterygii brd8 35
  • 58.67 (n)
  • 56.78 (a)
Dr.9079 35
brd8 36
  • 47 (a)
OneToMany
BRD8 (2 of 2) 36
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Brd8 36
  • 22 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14245 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9046 36
  • 42 (a)
OneToOne
Species with no ortholog for BRD8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRD8 Gene

ENSEMBL:
Gene Tree for BRD8 (if available)
TreeFam:
Gene Tree for BRD8 (if available)

Paralogs for BRD8 Gene

No data available for Paralogs for BRD8 Gene

Variants for BRD8 Gene

Sequence variations from dbSNP and Humsavar for BRD8 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs217261 -- 138,143,607(+) atcag(C/T)gctct intron-variant
rs217262 -- 138,144,406(+) cattc(C/T)tgaag intron-variant
rs217263 -- 138,144,977(+) AAAAA(C/G)CCTAT intron-variant
rs217270 -- 138,149,603(+) AAGTA(C/T)GAATC intron-variant
rs217271 -- 138,150,226(+) GAGAC(C/T)CCTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BRD8 Gene

Variant ID Type Subtype PubMed ID
esv2730819 CNV Deletion 23290073
esv2730820 CNV Deletion 23290073

Relevant External Links for BRD8 Gene

HapMap Linkage Disequilibrium report
BRD8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRD8 Gene

Disorders for BRD8 Gene

(3) Novoseek inferred disease relationships for BRD8 Gene

Disease -log(P) Hits PubMed IDs
immunodeficiency 15.4 1
tumors 0 1
cancer 0 1

Relevant External Links for BRD8

Genetic Association Database (GAD)
BRD8
Human Genome Epidemiology (HuGE) Navigator
BRD8
genes like me logo Genes that share disorders with BRD8: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for BRD8 Gene

Publications for BRD8 Gene

  1. Isolation and characterization of a novel ligand-dependent thyroid hormone receptor-coactivating protein. (PMID: 9368056) Monden T. … Hollenberg A.N. (J. Biol. Chem. 1997) 2 3 4 23
  2. Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. (PMID: 12963728) Cai Y. … Conaway J.W. (J. Biol. Chem. 2003) 3 4 23
  3. Cloning and sequencing of a human cDNA encoding a putative transcription factor containing a bromodomain. (PMID: 8611617) Nielsen M.S. … Madsen P. (Biochim. Biophys. Acta 1996) 2 3 4
  4. p120 acts as a specific coactivator for 9-cis-retinoic acid receptor (RXR) on peroxisome proliferator-activated receptor-gamma/RXR heterodimers. (PMID: 10517671) Monden T. … Mori M. (Mol. Endocrinol. 1999) 3 4
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4

Products for BRD8 Gene

Sources for BRD8 Gene

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