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Aliases for BRD8 Gene

Aliases for BRD8 Gene

  • Bromodomain Containing 8 2 3 5
  • Thyroid Hormone Receptor Coactivating Protein Of 120 KDa 3 4
  • Skeletal Muscle Abundant Protein 2 3 4
  • TrCP120 3 4
  • SMAP2 3 4
  • SMAP 3 4
  • P120 3 4
  • Bromodomain-Containing Protein 8 3
  • Skeletal Muscle Abundant Protein 4

External Ids for BRD8 Gene

Previous GeneCards Identifiers for BRD8 Gene

  • GC05M137506
  • GC05M137551
  • GC05M137503
  • GC05M137475
  • GC05M132666

Summaries for BRD8 Gene

Entrez Gene Summary for BRD8 Gene

  • The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Multiple alternatively spliced transcript variants that encode distinct isoforms have been identified. [provided by RefSeq, Jul 2014]

GeneCards Summary for BRD8 Gene

BRD8 (Bromodomain Containing 8) is a Protein Coding gene. Among its related pathways are Chromatin organization. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and thyroid hormone receptor activity.

UniProtKB/Swiss-Prot for BRD8 Gene

  • May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.

Gene Wiki entry for BRD8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRD8 Gene

Genomics for BRD8 Gene

Regulatory Elements for BRD8 Gene

Enhancers for BRD8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F138222 0.9 Ensembl ENCODE 11.3 -44.0 -43993 0.5 ELF3 TBP CBX3 ARID4B ZNF48 ZSCAN9 RAD21 RARA RFX5 ZNF366 GFRA3 BRD8 KIF20A CDC23 GC05M138210
GH05F138390 0.2 ENCODE 11.2 -212.9 -212923 2.5 CTCF RAD21 GFRA3 KDM3B ENSG00000249971 BRD8 KIF20A HSPA9 ENSG00000222937 SNORD63 NME5 RNU6-888P
GH05F138148 0.4 Ensembl 11.1 +30.0 29986 0.4 KLF1 JUND RAD51 JUN IKZF1 FOS RNU6-888P KIF20A BRD8 RNU6-1148P WNT8A GFRA3 NME5
GH05F138231 0.5 Ensembl 10.6 -52.2 -52216 0.4 KLF1 FEZF1 ZNF664 PATZ1 PRDM10 ZNF600 MAZ NFIA HLF REST GFRA3 FAM53C CDC25C KIF20A BRD8 REEP2 GC05M138210 CDC23
GH05F138366 1.1 Ensembl ENCODE 10.4 -190.2 -190215 6.0 ZNF121 ZNF316 PKNOX1 SCRT2 EMSY WT1 MAFK ATF2 NR2F2 FAM53C CDC25C BRD8 KIF20A HSPA9 GFRA3 KDM3B REEP2 GC05P138377
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around BRD8 on UCSC Golden Path with GeneCards custom track

Promoters for BRD8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001291223 -114 3001 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for BRD8 Gene

Chromosome:
5
Start:
138,139,766 bp from pter
End:
138,178,986 bp from pter
Size:
39,221 bases
Orientation:
Minus strand

Genomic View for BRD8 Gene

Genes around BRD8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRD8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRD8 Gene

Proteins for BRD8 Gene

  • Protein details for BRD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0E9-BRD8_HUMAN
    Recommended name:
    Bromodomain-containing protein 8
    Protein Accession:
    Q9H0E9
    Secondary Accessions:
    • O43178
    • Q15355
    • Q58AB0
    • Q59GN0
    • Q969M9

    Protein attributes for BRD8 Gene

    Size:
    1235 amino acids
    Molecular mass:
    135336 Da
    Quaternary structure:
    • Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. BRD8 isoform 2 interacts with RXRA/NR2B1 and THRB/ERBA2 (By similarity). Component of a SWR1-like complex.
    SequenceCaution:
    • Sequence=AAB87858.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH08039.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH08076.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA63925.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for BRD8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BRD8 Gene

Post-translational modifications for BRD8 Gene

No Post-translational modifications

No data available for DME Specific Peptides for BRD8 Gene

Domains & Families for BRD8 Gene

Protein Domains for BRD8 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for BRD8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0E9

UniProtKB/Swiss-Prot:

BRD8_HUMAN :
  • Contains 2 bromo domains.
Domain:
  • Contains 2 bromo domains.
genes like me logo Genes that share domains with BRD8: view

No data available for Gene Families for BRD8 Gene

Function for BRD8 Gene

Molecular function for BRD8 Gene

UniProtKB/Swiss-Prot Function:
May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome.

Gene Ontology (GO) - Molecular Function for BRD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 8611617
GO:0004887 thyroid hormone receptor activity TAS 9368056
genes like me logo Genes that share ontologies with BRD8: view
genes like me logo Genes that share phenotypes with BRD8: view

Animal Models for BRD8 Gene

MGI Knock Outs for BRD8:
  • Brd8 tm1a(EUCOMM)Wtsi

Animal Model Products

miRNA for BRD8 Gene

miRTarBase miRNAs that target BRD8

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BRD8 Gene

Localization for BRD8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRD8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BRD8 Gene COMPARTMENTS Subcellular localization image for BRD8 gene
Compartment Confidence
mitochondrion 5
nucleus 5
golgi apparatus 2
cytosol 1
endosome 1

Gene Ontology (GO) - Cellular Components for BRD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000812 Swr1 complex IDA 24463511
GO:0005634 nucleus NAS 8611617
GO:0005654 nucleoplasm TAS --
GO:0005739 mitochondrion IDA --
GO:0035267 NuA4 histone acetyltransferase complex IDA 14966270
genes like me logo Genes that share ontologies with BRD8: view

Pathways & Interactions for BRD8 Gene

genes like me logo Genes that share pathways with BRD8: view

Pathways by source for BRD8 Gene

Gene Ontology (GO) - Biological Process for BRD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 8611617
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 9368056
GO:0007165 signal transduction TAS 9368056
GO:0007166 cell surface receptor signaling pathway TAS 9368056
genes like me logo Genes that share ontologies with BRD8: view

No data available for SIGNOR curated interactions for BRD8 Gene

Drugs & Compounds for BRD8 Gene

(7) Drugs for BRD8 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CPI-203 Pharma BET bromodomain inhibitor 0
I-BET151 (GSK1210151A) Pharma Selective BET inhibitor 0
MS436 Pharma BRD4 inhibitor 0
OF-1 Pharma BRPF1B and BRPF2 bromodomain inhibitor 0
PFI-1 (PF-6405761) Pharma BET inhibitor 0

(6) ApexBio Compounds for BRD8 Gene

Compound Action Cas Number
CPI-203 BET bromodomain inhibitor 1446144-04-2
I-BET151 (GSK1210151A) Selective BET inhibitor 1300031-49-5
MS436 BRD4 inhibitor 1395084-25-9
OF-1 BRPF1B and BRPF2 bromodomain inhibitor 919973-83-4
PFI-1 (PF-6405761) BET inhibitor 1403764-72-6
UNC1215 Chemical probe for the methyllysine (Kme) 1415800-43-9
genes like me logo Genes that share compounds with BRD8: view

Transcripts for BRD8 Gene

Unigene Clusters for BRD8 Gene

Bromodomain containing 8:
Representative Sequences:

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BRD8 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5:
SP6:
SP7: -
SP8: -
SP9:
SP10:
SP11:
SP12: - - - - - - - - - - -

ExUns: 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26a · 26b · 26c · 26d ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32a · 32b ^ 33
SP1: - -
SP2: - - -
SP3: - - -
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9: -
SP10: - - - - - - -
SP11:
SP12: - - - -

Relevant External Links for BRD8 Gene

GeneLoc Exon Structure for
BRD8
ECgene alternative splicing isoforms for
BRD8

Expression for BRD8 Gene

mRNA expression in normal human tissues for BRD8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BRD8 Gene

This gene is overexpressed in Testis (21.6) and Peripheral blood mononuclear cells (14.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BRD8 Gene



Protein tissue co-expression partners for BRD8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BRD8 Gene:

BRD8

SOURCE GeneReport for Unigene cluster for BRD8 Gene:

Hs.519337

mRNA Expression by UniProt/SwissProt for BRD8 Gene:

Q9H0E9-BRD8_HUMAN
Tissue specificity: Expressed in adipose tissue, brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.
genes like me logo Genes that share expression patterns with BRD8: view

Primer Products

No data available for mRNA differential expression in normal tissues for BRD8 Gene

Orthologs for BRD8 Gene

This gene was present in the common ancestor of animals.

Orthologs for BRD8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BRD8 34 35
  • 99.68 (n)
cow
(Bos Taurus)
Mammalia BRD8 34 35
  • 93.63 (n)
dog
(Canis familiaris)
Mammalia BRD8 34 35
  • 93.32 (n)
mouse
(Mus musculus)
Mammalia Brd8 34 16 35
  • 90.42 (n)
rat
(Rattus norvegicus)
Mammalia Brd8 34
  • 89.33 (n)
oppossum
(Monodelphis domestica)
Mammalia BRD8 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BRD8 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves BRD8 34 35
  • 75.34 (n)
lizard
(Anolis carolinensis)
Reptilia BRD8 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia brd8 34
  • 69.79 (n)
Str.15923 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15498 34
zebrafish
(Danio rerio)
Actinopterygii brd8 34 35
  • 58.67 (n)
BRD8 (2 of 2) 35
  • 47 (a)
OneToMany
Dr.9079 34
fruit fly
(Drosophila melanogaster)
Insecta Brd8 35
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9046 35
  • 42 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14245 34
Species where no ortholog for BRD8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRD8 Gene

ENSEMBL:
Gene Tree for BRD8 (if available)
TreeFam:
Gene Tree for BRD8 (if available)

Paralogs for BRD8 Gene

No data available for Paralogs for BRD8 Gene

Variants for BRD8 Gene

Sequence variations from dbSNP and Humsavar for BRD8 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10038448 -- 138,180,092(+) AAATA(C/G)CCTCA intron-variant, upstream-variant-2KB
rs10051112 -- 138,177,701(+) TTGGA(A/C)ACAAC intron-variant, upstream-variant-2KB
rs10053065 -- 138,143,615(+) tctgt(A/G)tctag intron-variant
rs10053068 -- 138,143,637(+) taaac(A/G)cacca intron-variant
rs10053073 -- 138,143,649(+) tcagc(A/G)ctctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BRD8 Gene

Variant ID Type Subtype PubMed ID
esv2730819 CNV deletion 23290073
esv2730820 CNV deletion 23290073
esv3566699 CNV deletion 23714750
nsv1111682 CNV deletion 24896259
nsv1121334 CNV deletion 24896259

Variation tolerance for BRD8 Gene

Residual Variation Intolerance Score: 9.67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.07; 84.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BRD8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BRD8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRD8 Gene

Disorders for BRD8 Gene

Relevant External Links for BRD8

Genetic Association Database (GAD)
BRD8
Human Genome Epidemiology (HuGE) Navigator
BRD8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BRD8

No disorders were found for BRD8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BRD8 Gene

Publications for BRD8 Gene

  1. Isolation and characterization of a novel ligand-dependent thyroid hormone receptor-coactivating protein. (PMID: 9368056) Monden T. … Hollenberg A.N. (J. Biol. Chem. 1997) 2 3 4 22 64
  2. Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. (PMID: 12963728) Cai Y. … Conaway J.W. (J. Biol. Chem. 2003) 3 4 22 64
  3. Cloning and sequencing of a human cDNA encoding a putative transcription factor containing a bromodomain. (PMID: 8611617) Nielsen M.S. … Madsen P. (Biochim. Biophys. Acta 1996) 2 3 4 64
  4. ANP32E is a histone chaperone that removes H2A.Z from chromatin. (PMID: 24463511) Obri A. … Hamiche A. (Nature 2014) 3 4 64
  5. SMAP2, a novel ARF GTPase-activating protein, interacts with clathrin and clathrin assembly protein and functions on the AP-1-positive early endosome/trans-Golgi network. (PMID: 16571680) Natsume W. … Satake M. (Mol. Biol. Cell 2006) 3 22 64

Products for BRD8 Gene

Sources for BRD8 Gene

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