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BRD8 Gene

protein-coding   GIFtS: 58
GCID: GC05M137475

Bromodomain Containing 8

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Bromodomain Containing 81 2     p1202 3
Skeletal Muscle Abundant Protein 22 3     Bromodomain-Containing Protein 82
Thyroid Hormone Receptor Coactivating Protein Of 120 KDa2 3     trCP1202
SMAP2 3     TrCP1203
SMAP22 3     Skeletal Muscle Abundant Protein3

External Ids:    HGNC: 198741   Entrez Gene: 109022   Ensembl: ENSG000001129837   OMIM: 6028485   UniProtKB: Q9H0E93   

Export aliases for BRD8 gene to outside databases

Previous GC identifers: GC05M138150 GC05M137506 GC05M137551 GC05M137503 GC05M132666


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BRD8 Gene:
The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances
thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is
thought to be a nuclear receptor coactivator. Three alternatively spliced transcript variants that encode
distinct isoforms have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for BRD8 Gene:
BRD8 (bromodomain containing 8) is a protein-coding gene. GO annotations related to this gene include thyroid hormone receptor activity and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: BRD8_HUMAN, Q9H0E9
Function: May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR).
Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least
isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in
transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This
modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with
other proteins which positively regulate transcription. This complex may be required for the activation of
transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor
mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in
DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the
removal of histone H2A.Z/H2AFZ from the nucleosome

Gene Wiki entry for BRD8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BRD8 gene promoter:
         Lmo2   RelA   CBF-C   c-Ets-1   PPAR-alpha   CBF-A   CBF-B   CP1C   CP1A   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBRD8 promoter sequence
   Search Chromatin IP Primers for BRD8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BRD8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5q31.2   HGNC cytogenetic band: 5q31

BRD8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRD8 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M137475:  view genomic region     (about GC identifiers)

Start:
137,475,455 bp from pter      End:
137,514,675 bp from pter
Size:
39,221 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: BRD8_HUMAN, Q9H0E9 (See protein sequence)
Recommended Name: Bromodomain-containing protein 8  
Size: 1235 amino acids; 135336 Da
Subunit: Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60
and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin,
ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts
with MYC and the adenovirus E1A protein. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400,
SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. BRD8
isoform 2 interacts with RXRA/NR2B1 and THRB/ERBA2 (By similarity). Component of a SWR1-like complex
Caution: It is uncertain whether Met-1 or Met-32 is the initiator
Sequence caution: Sequence=AAB87858.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH08039.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH08076.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA63925.1; Type=Erroneous
initiation; Note=Translation N-terminally extended;
Secondary accessions: O43178 Q15355 Q58AB0 Q59GN0 Q969M9
Alternative splicing: 4 isoforms:  Q9H0E9-1   Q9H0E9-2   Q9H0E9-3   Q9H0E9-4   (Contains a phosphothreonine at position 264. Contains a phosphoserine at position 268. Contains a phosphoserine at position 284)

Explore the universe of human proteins at neXtProt for BRD8: NX_Q9H0E9

Explore proteomics data for BRD8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BRD8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001157798.1  NP_006687.3  NP_631938.1  

    ENSEMBL proteins: 
     ENSP00000254900   ENSP00000392646   ENSP00000420884   ENSP00000398084   ENSP00000398067  
     ENSP00000398873   ENSP00000230901   ENSP00000384845   ENSP00000427475   ENSP00000427126  
     ENSP00000426385   ENSP00000407129   ENSP00000414625   ENSP00000398676   ENSP00000396487  
     ENSP00000407414   ENSP00000394330   ENSP00000408396  
    Reactome Protein details: Q9H0E9

    BRD8 Human Recombinant Protein Products:

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    Novus Biologicals BRD8 Protein
    Novus Biologicals BRD8 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BRD8

     
    Search eBioscience for Proteins for BRD8 

     
    antibodies-online proteins for BRD8 (2 products) 

     
    antibodies-online peptides for BRD8

    BRD8 Antibody Products:

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    antibodies-online antibodies for BRD8 (28 products) 

    BRD8 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for BRD8
    Cloud-Clone Corp. CLIAs for BRD8
    Search eBioscience for ELISAs for BRD8 
    antibodies-online kits for BRD8 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001487 Bromodomain

    Graphical View of Domain Structure for InterPro Entry Q9H0E9

    ProtoNet protein and cluster: Q9H0E9

    1 Blocks protein domain: IPB001487 Bromodomain signature

    UniProtKB/Swiss-Prot: BRD8_HUMAN, Q9H0E9
    Similarity: Contains 2 bromo domains


    Find genes that share domains with BRD8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BRD8_HUMAN, Q9H0E9
    Function: May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR).
    Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least
    isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in
    transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This
    modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with
    other proteins which positively regulate transcription. This complex may be required for the activation of
    transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor
    mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in
    DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the
    removal of histone H2A.Z/H2AFZ from the nucleosome

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity NAS8611617
    GO:0004887thyroid hormone receptor activity TAS9368056
    GO:0005515protein binding ----
         
    Find genes that share ontologies with BRD8           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for BRD8:
     Increased HPV18 LCR reporter a 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Brd8):
     mortality/aging 

    Find genes that share phenotypes with BRD8           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BRD8
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BRD8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BRD8

    miRNA
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    miRTarBase miRNAs that target BRD8:
    hsa-mir-26b-5p (MIRT030145), hsa-mir-24-3p (MIRT030616), hsa-mir-92b-3p (MIRT040691)

    Block miRNA regulation of human, mouse, rat BRD8 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate BRD8:
    hsa-miR-877* hsa-miR-18b* hsa-miR-3182
    SwitchGear 3'UTR luciferase reporter plasmidBRD8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BRD8
    Predesigned siRNA for gene silencing in human, mouse, rat BRD8

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): BRD8 (NM_006696)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BRD8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRD8

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRD8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BRD8_HUMAN, Q9H0E9: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion4
    cytosol1
    endosome1
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000812Swr1 complex IDA--
    GO:0005634nucleus NAS8611617
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005739mitochondrion IDA--

    Find genes that share ontologies with BRD8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BRD8 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    HATs acetylate histones0.34
    Chromatin organization0.34
    Chromatin modifying enzymes0.34


    Find genes that share SuperPaths with BRD8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for BRD8
        HATs acetylate histones


        Pathway & Disease-focused RT2 Profiler PCR Arrays including BRD8: 
              Nuclear Receptors & Coregulators in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BRD8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BRD8 (Q9H0E92, 3 ENSP000002549004) via UniProtKB, MINT, STRING, and/or I2D (see all 877)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DMAP1Q9NPF52, 3, ENSP000003126974MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000312697
    RUVBL2Q9Y2302, 3, ENSP000002214134MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000221413
    MORF4L1Q9UBU82, 3, ENSP000003313104MINT-7945693 I2D: score=2 STRING: ENSP00000331310
    MORF4L2Q150142, 3MINT-7945693 I2D: score=2 
    ACTL6AO960192, 3, ENSP000003975524MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000397552
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006325chromatin organization TAS--
    GO:0006355regulation of transcription, DNA-templated NAS8611617
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9368056
    GO:0007165signal transduction TAS9368056
    GO:0007166cell surface receptor signaling pathway TAS9368056

    Find genes that share ontologies with BRD8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for BRD8 (see all 11)     About this table
    CompoundAction CAS #
    (+)-JQ1BET bromodomain inhibitor[1268524-70-4]
    (-)-JQ1Inactive stereoisomer of bromodomain inhibitor (+)-JQ1[1268524-71-5]
    Bromosporinebroad spectrum inhibitor for bromodomains--
    I-BET-762inhibitor for BET proteins[1260907-17-2]
    I-BET151 (GSK1210151A)BET bromodomain inhibitor(pIC50=6.1,BRD4)[1300031-49-5]
    OTX-015new potent BRD-inhibitor [202590-98-5]
    PFI-1 (PF-6405761)selective BET inhibitor for BRD4[1403764-72-6]
    RVX-208potent BET bromodomain inhibitor for BD2[1044870-39-4]
    SGC-CBP30Potent CREBBP/EP300 bromodomain inhibitor--
    UNC1215elective MBT antagonist[1415800-43-9]

    Browse Tocris compounds for BRD8

    1 Novoseek inferred chemical compound relationship for BRD8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 21.1 7 2110361 (2), 1372401 (2), 7504542 (1)



    Find genes that share compounds with BRD8           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BRD8 gene (4 alternative transcripts): 
    NM_001164326.1  NM_006696.3  NM_139199.1  NM_183359.1  

    Unigene Cluster for BRD8:

    Bromodomain containing 8
    Hs.519337  [show with all ESTs]
    Unigene Representative Sequence: NM_139199
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000254900(uc003lcf.1) ENST00000427976 ENST00000472478 ENST00000441656
    ENST00000454473(uc021yea.1) ENST00000418329 ENST00000230901(uc003lcg.3)
    ENST00000402931(uc011cyl.2 uc011cym.2 uc011cyn.1) ENST00000512140
    ENST00000460746 ENST00000489351 ENST00000515014 ENST00000506167 ENST00000511898
    ENST00000483805 ENST00000463620 ENST00000453824 ENST00000471892
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate BRD8:
    hsa-miR-877* hsa-miR-18b* hsa-miR-3182
    SwitchGear 3'UTR luciferase reporter plasmidBRD8 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat BRD8
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): BRD8 (NM_006696)
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BRD8
      QuantiTect SYBR Green Assays in human, mouse, rat BRD8
      QuantiFast Probe-based Assays in human, mouse, rat BRD8

    Additional mRNA sequence: 

    AB209079.1 AF016270.1 AK124191.1 AK225928.1 AK289951.1 AK297608.1 AK310380.1 AK312333.1 
    AL136823.1 BC008039.2 BC008076.2 X87613.1 X94234.1 

    24 DOTS entries:

    DT.100764757  DT.100892231  DT.95158841  DT.445848  DT.95158808  DT.91966681  DT.92440388  DT.120861046 
    DT.100892246  DT.120861058  DT.120861110  DT.40130768  DT.100892241  DT.92440405  DT.440036  DT.86847822 
    DT.95158853  DT.95178288  DT.95180637  DT.100045414  DT.40300550  DT.91924556  DT.100724741  DT.95160576 

    Selected AceView cDNA sequences (see all 317):

    AI039447 T50434 AI343578 H56771 BX951561 BC008039 AU120164 BM818263 
    BG286394 BP381922 BM930647 BM695134 BQ878177 BQ270729 BM709234 AI191290 
    CD244518 AF016270 AI568113 AI989293 BU956635 NM_183359 AI393010 BU189468 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BRD8 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
    SP1:                    -                 -                                               -                                                                     
    SP2:                    -                 -                                               -     -                                                               
    SP3:                    -                 -                                               -     -     -                                                         
    SP4:                                                                          -           -                                                                     
    SP5:                                                                                                                                                            

    ExUns: 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26a · 26b · 26c · 26d ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32a · 32b ^ 33
    SP1:                          -     -                                                                                       
    SP2:                    -     -     -                                                                                       
    SP3:                    -     -     -                                                                                       
    SP4:                                                                                                                        
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for BRD8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BRD8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTATGTTA
    BRD8 Expression
    About this image


    BRD8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             Testis Interstitium
     
     Eye (Sensory Organs)
             Retina
     
     Uterus (Reproductive System)
    BRD8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BRD8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.519337

    UniProtKB/Swiss-Prot: BRD8_HUMAN, Q9H0E9
    Tissue specificity: Expressed in adipose tissue, brain, heart, kidney, liver, lung, pancreas, placenta and
    skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BRD8: 
              Nuclear Receptors & Coregulators in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BRD8 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Brd81 , 5 bromodomain containing 81, 5 90.42(n)1
    94.44(a)1
      18 (18.69 cM)5
    786561  NM_030147.21  NP_084423.21 
     345986155 
    chicken
    (Gallus gallus)
    Aves BRD81 bromodomain containing 8 75.34(n)
    78.38(a)
      416219  NM_001006148.1  NP_001006148.1 
    lizard
    (Anolis carolinensis)
    Reptilia BRD86
    bromodomain containing 8
    63(a)
    1 ↔ 1
    2(146253686-146303131)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.154982 Xenopus laevis transcribed sequence with weak similarity more 82.05(n)    BX853409.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.90792 Danio rerio, Similar to bromodomain containing 8, clone more 76.72(n)    BC044181.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Brd86
    Brd8
    22(a)
    1 ↔ 1
    3R(25049213-25051998)


    ENSEMBL Gene Tree for BRD8 (if available)
    TreeFam Gene Tree for BRD8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BRD8 (see all 904)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs349360681,2
    C--132666019(+) CTCTAG/AGTCCG 1 -- ds50011Minor allele frequency- A:0.00NA 2
    rs176377201,2
    C,F,H--132666079(+) AGTACT/GCACCT 1 -- ds50019Minor allele frequency- G:0.02NA NS 940
    rs1834523541,2
    C--132666099(+) TCCTCA/CTATGG 1 -- ds50010--------
    rs1466583801,2
    --132666105(+) TATGGC/TACAAC 1 -- ds50010--------
    rs1402190311,2
    --132666398(+) TAAATA/GACCCG 1 -- ds50010--------
    rs1885888141,2
    --132666407(+) CGTGTA/CAGATA 1 -- ds50010--------
    rs1455748501,2
    C--132666494(+) TAAATA/GCATTT 1 -- ut310--------
    rs1166249461,2
    C,F--132666667(+) GTTAAG/AGTATT 1 -- ut311Minor allele frequency- A:0.09WA 118
    rs4232581,2
    C,F,A,H--132666810(+) TCATCC/TACTGG 2 V syn1 ese327Minor allele frequency- T:0.31EA MN NS NA CSA WA EU 10249
    rs1995220041,2
    --132666823(+) TAGCTC/GGTTCT 2 P R mis10--------

    HapMap Linkage Disequilibrium report for BRD8 (137475455 - 137514675 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for BRD8:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2730820CNV Deletion23290073
    esv2730819CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BRD8
    DNA2.0 Custom Variant and Variant Library Synthesis for BRD8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602848    OMIM disorders: --


    Find genes that share disorders with BRD8           About GenesLikeMe

    3 Novoseek inferred disease relationships for BRD8 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    immunodeficiency 15.4 1 18475387 (1)
    tumors 0 1 8287366 (1)
    cancer 0 1 9211983 (1)

    Genetic Association Database (GAD): BRD8
    Human Genome Epidemiology (HuGE) Navigator: BRD8 (1 document)

    Export disorders for BRD8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BRD8 gene, integrated from 10 sources (see all 59):
    (articles sorted by number of sources associating them with BRD8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a novel ligand-dependent thyroid hormone receptor-coactivating protein. (PubMed id 9368056)1, 2, 3, 9 Monden T.... Hollenberg A.N. (J. Biol. Chem. 1997)
    2. Cloning and sequencing of a human cDNA encoding a putative transcription factor containing a bromodomain. (PubMed id 8611617)1, 2, 3 Nielsen M.S.... Madsen P. (Biochim. Biophys. Acta 1996)
    3. Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. (PubMed id 12963728)1, 2, 9 Cai Y.... Conaway J.W. (J. Biol. Chem. 2003)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. The highly conserved and multifunctional NuA4 HAT complex. (PubMed id 15196461)1, 2 Doyon Y. and Cote J. (Curr. Opin. Genet. Dev. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. (PubMed id 14966270)1, 2 Doyon Y.... Cote J. (Mol. Cell. Biol. 2004)
    8. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    9. p120 acts as a specific coactivator for 9-cis-retinoic acid receptor (RXR) on peroxisome proliferator-activated receptor-gamma/RXR heterodimers. (PubMed id 10517671)1, 2 Monden T.... Mori M. (Mol. Endocrinol. 1999)
    10. SMAP2, a novel ARF GTPase-activating protein, interacts with clathrin and clathrin assembly protein and functions on the AP-1-positive early endosome/trans-Golgi network. (PubMed id 16571680)1, 9 Natsume W....Satake M. (Mol. Biol. Cell 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10902 HGNC: 19874 AceView: BRD8 Ensembl:ENSG00000112983 euGenes: HUgn10902
    ECgene: BRD8 H-InvDB: BRD8

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BRD8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BRD8 gene:
    Search GeneIP for patents involving BRD8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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