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BRD7 Gene

protein-coding   GIFtS: 53
GCID: GC16M050352

Bromodomain Containing 7

(Previous name: bromodomain-containing 7)
  See BRD7-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Bromodomain Containing 71 2     CELTIX12 3
Protein CELTIX-12 3     Bromodomain-Containing 71
75 KDa Bromodomain Protein2 3     NAG42
BP752 3     Bromodomain-Containing Protein 72

External Ids:    HGNC: 143101   Entrez Gene: 291172   Ensembl: ENSG000001661647   UniProtKB: Q9NPI13   

Export aliases for BRD7 gene to outside databases

Previous GC identifers: GC16M040766 GC16M050400 GC16M050088 GC16M050130 GC16M048910 GC16M036240


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BRD7 Gene:
This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this
gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein
which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor
growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in
multiple transcript variants. (provided by RefSeq, Jul 2010)

GeneCards Summary for BRD7 Gene:
BRD7 (bromodomain containing 7) is a protein-coding gene. Diseases associated with BRD7 include nasopharynx carcinoma. GO annotations related to this gene include transcription corepressor activity and transcription factor binding. An important paralog of this gene is BRD9.

UniProtKB/Swiss-Prot: BRD7_HUMAN, Q9NPI1
Function: Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the
Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity.
Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional
activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes.
Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1
promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of
transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene
activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to
target promoters. Inhibits cell cycle progression from G1 to S phase

Gene Wiki entry for BRD7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BRD7 gene promoter:
         Max   AhR   RP58   HSF2   NRSF form 1   NRSF form 2   c-Myc   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBRD7 promoter sequence
   Search Chromatin IP Primers for BRD7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BRD7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q12   Ensembl cytogenetic band:  16q12.1   HGNC cytogenetic band: 16q12.1

BRD7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRD7 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M050352:  view genomic region     (about GC identifiers)

Start:
50,347,398 bp from pter      End:
50,402,845 bp from pter
Size:
55,448 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: BRD7_HUMAN, Q9NPI1 (See protein sequence)
Recommended Name: Bromodomain-containing protein 7  
Size: 651 amino acids; 74139 Da
Subunit: Interacts with TRIM24, PTPN13 and DVL1. Identified in a complex with SMARCA4/BRG1, SMARCC1/BAF155,
SMARCE1/BAF57, DPF2/BAF45D and ARID2, subunits of the SWI/SNF-B (PBAF) chromatin remodeling complex (By
similarity). Interacts with IRF2 and HNRPUL1. Interacts (via N-terminus) with TP53. Interacts (via C-terminus)
with EP300. Interacts with BRCA1. Interacts (via bromo domain) with histone H3 (via N-terminus) acetylated at
'Lys-14' (H3K14ac). Has low affinity for histone H3 acetylated at 'Lys-9' (H3K9ac). Has the highest affinity for
histone H3 that is acetylated both at 'Lys-9' (H3K9ac) and at 'Lys-14' (H3K14ac). Has very low affinity for
non-acetylated histone H3. Interacts (via bromo domain) with histone H4 (via N-terminus) acetylated at 'Lys-8'
(H3K8ac) (in vitro)
Sequence caution: Sequence=AAH01611.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB55031.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC11089.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for BRD7:
2I7K (3D)    
Secondary accessions: Q4VC09 Q8N2L9 Q96KA4 Q9BV48 Q9UH59
Alternative splicing: 2 isoforms:  Q9NPI1-1   Q9NPI1-2   

Explore the universe of human proteins at neXtProt for BRD7: NX_Q9NPI1

Explore proteomics data for BRD7 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys21, Lys186, Lys305
  • Modification sites at PhosphoSitePlus

  • See BRD7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001167455.1  NP_037395.2  

    ENSEMBL proteins: 
     ENSP00000458430   ENSP00000461556   ENSP00000378180   ENSP00000378181  

    BRD7 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for BRD7

     
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    antibodies-online proteins for BRD7 (4 products) 

     
    antibodies-online peptides for BRD7

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    antibodies-online antibodies for BRD7 (30 products) 

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    antibodies-online kits for BRD7 (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001487 Bromodomain
     IPR021900 DUF3512

    Graphical View of Domain Structure for InterPro Entry Q9NPI1

    ProtoNet protein and cluster: Q9NPI1

    1 Blocks protein domain: IPB001487 Bromodomain signature

    UniProtKB/Swiss-Prot: BRD7_HUMAN, Q9NPI1
    Similarity: Contains 1 bromo domain


    Find genes that share domains with BRD7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BRD7_HUMAN, Q9NPI1
    Function: Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the
    Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity.
    Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional
    activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes.
    Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1
    promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of
    transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene
    activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to
    target promoters. Inhibits cell cycle progression from G1 to S phase

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IPI--
    GO:0003713transcription coactivator activity IDA--
    GO:0003714transcription corepressor activity ISS--
    GO:0005515protein binding IPI12489984
    GO:0008134transcription factor binding IDA11025449
         
    Find genes that share ontologies with BRD7           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Brd7):
     integument  mortality/aging  nervous system 

    Find genes that share phenotypes with BRD7           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for BRD7

    miRNA
    Products:
        
    miRTarBase miRNAs that target BRD7:
    hsa-mir-877-3p (MIRT037026), hsa-mir-200c-3p (MIRT006219), hsa-mir-99a-5p (MIRT048707), hsa-mir-1296-5p (MIRT036077)

    Block miRNA regulation of human, mouse, rat BRD7 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate BRD7:
    hsa-miR-520d-5p hsa-miR-889 hsa-miR-524-5p hsa-miR-556-3p hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmidBRD7 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for BRD7
    Predesigned siRNA for gene silencing in human, mouse, rat BRD7

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRD7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BRD7_HUMAN, Q9NPI1: Isoform 2: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11025449
    GO:0005737cytoplasm TAS10526152

    Find genes that share ontologies with BRD7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BRD7 About    
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt Signaling Pathway NetPath0.37


    1 BioSystems Pathway for BRD7
        Wnt Signaling Pathway NetPath


        Pathway & Disease-focused RT2 Profiler PCR Array including BRD7: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BRD7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BRD7 (Q9NPI11, 2, 3 ENSP000003781804) via UniProtKB, MINT, STRING, and/or I2D (see all 645)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628052, 3, ENSP000003529804MINT-6665465 I2D: score=3 STRING: ENSP00000352980
    HIST1H4LP628052, 3, ENSP000003482584MINT-6665465 I2D: score=3 STRING: ENSP00000348258
    HIST1H4BP628052, 3MINT-6665465 I2D: score=3 
    HIST1H4CP628052, 3MINT-6665465 I2D: score=3 
    HIST1H4DP628052, 3MINT-6665465 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter IDA12489984
    GO:0007049cell cycle IEA--
    GO:0008285negative regulation of cell proliferation IDA--
    GO:0016055Wnt signaling pathway IEA--

    Find genes that share ontologies with BRD7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for BRD7 (see all 11)     About this table
    CompoundAction CAS #
    (+)-JQ1BET bromodomain inhibitor[1268524-70-4]
    (-)-JQ1Inactive stereoisomer of bromodomain inhibitor (+)-JQ1[1268524-71-5]
    Bromosporinebroad spectrum inhibitor for bromodomains--
    I-BET-762inhibitor for BET proteins[1260907-17-2]
    I-BET151 (GSK1210151A)BET bromodomain inhibitor(pIC50=6.1,BRD4)[1300031-49-5]
    OTX-015new potent BRD-inhibitor [202590-98-5]
    PFI-1 (PF-6405761)selective BET inhibitor for BRD4[1403764-72-6]
    RVX-208potent BET bromodomain inhibitor for BD2[1044870-39-4]
    SGC-CBP30Potent CREBBP/EP300 bromodomain inhibitor--
    UNC1215elective MBT antagonist[1415800-43-9]

    Browse Tocris compounds for BRD7

    1 Novoseek inferred chemical compound relationship for BRD7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 24.6 1 15382140 (1)



    Find genes that share compounds with BRD7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BRD7 gene (2 alternative transcripts): 
    NM_001173984.2  NM_013263.4  

    Unigene Cluster for BRD7:

    Bromodomain containing 7
    Hs.437894  [show with all ESTs]
    Unigene Representative Sequence: NM_001173984
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000562383 ENST00000569774 ENST00000394688(uc021thx.1 uc002ege.2)
    ENST00000394689 ENST00000475877 ENST00000401491 ENST00000567826
    miRNA
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    hsa-miR-520d-5p hsa-miR-889 hsa-miR-524-5p hsa-miR-556-3p hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmidBRD7 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat BRD7

    Additional mRNA sequence: 

    AF152604.1 AF213969.1 AJ271881.1 AK027308.1 AK074613.1 BC001611.1 BC050728.1 BC094706.1 

    15 DOTS entries:

    DT.100791331  DT.454106  DT.451852  DT.97776225  DT.120916829  DT.120916851  DT.120656760  DT.100703997 
    DT.120656775  DT.95261691  DT.99997198  DT.100756739  DT.40232112  DT.75139342  DT.95220138 

    Selected AceView cDNA sequences (see all 303):

    AI304684 CA312534 BM699212 BU742219 BM466021 BM985285 BQ775912 BU620378 
    BI438648 AI191240 N43948 AK027308 AA292066 AA740455 BU627954 BQ686403 
    AA975938 CF529101 CA437083 BQ011423 AA904242 CR593793 N25720 AA235012 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BRD7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAACAACT
    BRD7 Expression
    About this image

    BRD7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BRD7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.437894
        Pathway & Disease-focused RT2 Profiler PCR Array including BRD7: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BRD7 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Brd71 , 5 bromodomain containing 71, 5 87.35(n)1
    88.17(a)1
      8 (43.07 cM)5
    269921  NM_012047.21  NP_036177.11 
     883310395 
    chicken
    (Gallus gallus)
    Aves BRD71 bromodomain containing 7 75.97(n)
    79.22(a)
      415730  NM_001005839.1  NP_001005839.1 
    lizard
    (Anolis carolinensis)
    Reptilia BRD76
    bromodomain containing 7
    70(a)
    1 ↔ 1
    GL343227.1(1686859-1704416)
    African clawed frog
    (Xenopus laevis)
    Amphibia BRD72 nuclear transcriptor-like protein 74.67(n)    AY256967.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.238942 Danio rerio cDNA clone MGC66347 IMAGE5604192, complete more 74.5(n)    BC055611.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG71546
    --
    22(a)
    1 → many
    2L(7782857-7786063)
    worm
    (Caenorhabditis elegans)
    Secernentea tag-2981 tag-298 45.64(n)
    33.47(a)
      172461  NM_059640.6  NP_492041.1 


    ENSEMBL Gene Tree for BRD7 (if available)
    TreeFam Gene Tree for BRD7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BRD7 gene
    BRD92  
    2 SIMAP similar genes for BRD7 using alignment to 3 protein entries:     BRD7_HUMAN (see all proteins):
    FT002    BRD9

    Find genes that share paralogs with BRD7           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for BRD7 (see all 8)
    PGOHUM00000248464 PGOHUM00000248110 PGOHUM00000240674 PGOHUM00000238129 PGOHUM00000238245


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BRD7 (see all 1204)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1428315431,2
    --36259053(+) TTCTT-/CTTTTT 2 -- int10--------
    rs105691821,2
    C--36262974(+) TAAGT-/ACacaca 2 -- int10--------
    rs774692841,2
    --36273644(+) TCGGTA/GTATCC 2 -- int11Minor allele frequency- G:0.00CSA 1
    rs785332271,2
    C,F--36273696(+) AATCAG/AGGTAA 2 -- int12Minor allele frequency- A:0.50NA WA 4
    rs347147811,2
    C--36274520(+) CTTTG-/G/TTTTTT 2 -- int12NA 4
    rs583561441,2
    C--36278539(+) AAAAA-/TATATA 2 -- int10--------
    rs1390259031,2
    C--36278539(+) AAAAA-/AATATATA 2 -- int10--------
    rs670321241,2
    C--36278541(+) AAAAA-/TTATAT 2 -- int10--------
    rs1511514321,2
    C--36290925(+) CTGCGC/GGTGGC 2 -- us2k10--------
    rs50012421,2
    --36290972(+) ggccgA/Ggggcg 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for BRD7 (50347398 - 50402845 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for BRD7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1806CNV Insertion18451855
    nsv1805CNV Loss18451855
    esv1011295OTHER Inversion20482838

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BRD7
    DNA2.0 Custom Variant and Variant Library Synthesis for BRD7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for BRD7:    
    About MalaCards
    nasopharynx carcinoma

    1 disease from the University of Copenhagen DISEASES database for BRD7:
    Nasopharynx carcinoma

    Find genes that share disorders with BRD7           About GenesLikeMe

    1 Novoseek inferred disease relationship for BRD7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 3 12918109 (2), 19949542 (1)

    Genetic Association Database (GAD): BRD7
    Human Genome Epidemiology (HuGE) Navigator: BRD7 (1 document)

    Export disorders for BRD7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BRD7 gene, integrated from 10 sources (see all 62):
    (articles sorted by number of sources associating them with BRD7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. BRD7 is a candidate tumour suppressor gene required for p53 function. (PubMed id 20228809)1, 2, 9 Drost J.... Del Sal G. (Nat. Cell Biol. 2010)
    2. Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2. (PubMed id 11025449)1, 2, 9 Staal A.... van Wijnen A.J. (J. Cell. Physiol. 2000)
    3. Identification and molecular characterization of BP75, a novel bromodomain-containing protein. (PubMed id 10526152)1, 3, 9 Cuppen E....Hendriks W. (FEBS Lett. 1999)
    4. Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence. (PubMed id 20660729)1, 2 Burrows A.E.... Elledge S.J. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    5. BRD7, a subunit of SWI/SNF complexes, binds directly to BRCA1 and regulates BRCA1-dependent transcription. (PubMed id 20215511)1, 2 Harte M.T.... Harkin D.P. (Cancer Res. 2010)
    6. BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells. (PubMed id 18809673)1, 3 Kaeser M.D....Emerson B.M. (J. Biol. Chem. 2008)
    7. [Expression and SNP analysis of BRD7 gene in acute leukemia cells]. (PubMed id 18772500)1, 4 Tang X.Y....Shen S.R. (Zhong Nan Da Xue Xue Bao Yi Xue Ban 2008)
    8. The transcriptional regulation role of BRD7 by binding to acetylated histone through bromodomain. (PubMed id 16265664)1, 2 Peng C.... Li G.Y. (J. Cell. Biochem. 2006)
    9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    10. Identification of nuclear localization signal that governs nuclear import of BRD7 and its essential roles in inhibiting cell cycle progression. (PubMed id 16475162)1, 2 Zhou M.... Li G. (J. Cell. Biochem. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29117 HGNC: 14310 AceView: BRD7 Ensembl:ENSG00000166164 euGenes: HUgn29117
    ECgene: BRD7 H-InvDB: BRD7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BRD7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BRD7 gene:
    Search GeneIP for patents involving BRD7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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