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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BRD7 Gene

protein-coding   GIFtS: 50
GCID: GC16M050352

bromodomain containing 7

(Previous name: bromodomain-containing 7 )
 Explore 7 diseases affiliated with
BRD7 via our new
 Human Malady Compendium 
Biological research products
for BRD7
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Bromodomain Containing 71 2     75 KDa Bromodomain Protein2 3
BP751 2 3     Bromodomain-Containing 71
CELTIX11 2 3     NAG42
Protein CELTIX-12 3     Bromodomain-Containing Protein 72

External Ids:    HGNC: 143101   Entrez Gene: 291172   Ensembl: ENSG000001661647   UniProtKB: Q9NPI13   

Export aliases for BRD7 gene to outside databases

Previous GC identifers: GC16M040766 GC16M050400 GC16M050088 GC16M050130 GC16M048910 GC16M036240


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BRD7:
This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene
has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which
interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth.
Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Jul 2010)

UniProtKB/Swiss-Prot: BRD7_HUMAN, Q9NPI1
Function: Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt
signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces
dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR
(By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target
promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1
and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes.
Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at
'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression
from G1 to S phase

Gene Wiki entry for BRD7


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BRD7 gene promoter:
         Max   AhR   RP58   HSF2   NRSF form 1   NRSF form 2   c-Myc   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBRD7 promoter sequence
   Search SABiosciences Chromatin IP Primers for BRD7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BRD7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q12   Ensembl cytogenetic band:  16q12.1   HGNC cytogenetic band: 16q12.1

BRD7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRD7 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M050352:  view genomic region     (about GC identifiers)

Start:
50,347,398 bp from pter      End:
50,402,845 bp from pter
Size:
55,448 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: BRD7_HUMAN, Q9NPI1 (See protein sequence)
Recommended Name: Bromodomain-containing protein 7  
Size: 651 amino acids; 74139 Da
Subunit: Interacts with TRIM24, PTPN13 and DVL1. Identified in a complex with SMARCA4/BRG1, SMARCC1/BAF155,
SMARCE1/BAF57, DPF2/BAF45D and ARID2, subunits of the SWI/SNF-B (PBAF) chromatin remodeling complex (By similarity).
Interacts with IRF2 and HNRPUL1. Interacts (via N-terminus) with TP53. Interacts (via C-terminus) with EP300.
Interacts with BRCA1. Interacts (via bromo domain) with histone H3 (via N-terminus) acetylated at 'Lys-14' (H3K14ac).
Has low affinity for histone H3 acetylated at 'Lys-9' (H3K9ac). Has the highest affinity for histone H3 that is
acetylated both at 'Lys-9' (H3K9ac) and at 'Lys-14' (H3K14ac). Has very low affinity for non-acetylated histone H3.
Interacts (via bromo domain) with histone H4 (via N-terminus) acetylated at 'Lys-8' (H3K8ac) (in vitro)
Subcellular location: Isoform 2: Nucleus
Sequence caution: Sequence=AAH01611.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB55031.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC11089.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for BRD7:
2I7K (3D)    
Secondary accessions: Q4VC09 Q8N2L9 Q96KA4 Q9BV48 Q9UH59
Alternative splicing: 2 isoforms:  Q9NPI1-1   Q9NPI1-2   

Explore the universe of human proteins at neXtProt for BRD7: NX_Q9NPI1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NPI1

  • BRD7 Protein expression data from MOPED and PaxDb:    About this image 
    BRD7 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001167455.1  NP_037395.2  

    ENSEMBL proteins: 
     ENSP00000458430   ENSP00000461556   ENSP00000378180   ENSP00000378181  

    Human Recombinant Protein Products for BRD7: 
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    Novus Biologicals BRD7 Protein
    Novus Biologicals BRD7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for BRD7

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12489984
    GO:0005737cytoplasm TAS10526152

    BRD7 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for BRD7


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    BRD7 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001487 Bromodomain
     IPR021900 DUF3512

    Graphical View of Domain Structure for InterPro Entry Q9NPI1

    ProtoNet protein and cluster: Q9NPI1

    1 Blocks protein family: IPB001487 Bromodomain signature

    UniProtKB/Swiss-Prot: BRD7_HUMAN, Q9NPI1
    Similarity: Contains 1 bromo domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BRD7_HUMAN, Q9NPI1
    Function: Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt
    signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces
    dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR
    (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target
    promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1
    and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes.
    Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at
    'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression
    from G1 to S phase

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IPI--
    GO:0003713transcription coactivator activity IDA--
    GO:0003714transcription corepressor activity ISS--
    GO:0005515protein binding IPI--
    GO:0008134transcription factor binding IDA11025449
         
    BRD7 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Brd7):
     integument  mortality/aging  nervous system 

    BRD7 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for BRD7 

    miRNA
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    hsa-miR-520d-5p hsa-miR-889 hsa-miR-524-5p hsa-miR-556-3p hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmidBRD7 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRD7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Wnt Signaling Pathway
    Wnt Signaling Pathway NetPath0.22


    1 BioSystems Pathway for BRD7 
        Wnt Signaling Pathway NetPath


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BRD7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/613 Interacting proteins for BRD7 (Q9NPI11, 2, 3 ENSP000003781804) via UniProtKB, MINT, STRING, and/or I2D (see all 613)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628052, 3, ENSP000003529804MINT-6665465 I2D: score=3 STRING: ENSP00000352980
    HIST1H4LP628052, 3, ENSP000003482584MINT-6665465 I2D: score=3 STRING: ENSP00000348258
    HIST1H4BP628052, 3MINT-6665465 I2D: score=3 
    HIST1H4CP628052, 3MINT-6665465 I2D: score=3 
    HIST1H4DP628052, 3MINT-6665465 I2D: score=3 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter IDA12489984
    GO:0007049cell cycle IEA--
    GO:0008285negative regulation of cell proliferation IDA--
    GO:0016055Wnt receptor signaling pathway IEA--

    BRD7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BRD7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BRD7
    1 Novoseek chemical compound relationship for BRD7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 24.6 1 15382140 (1)

    Search CenterWatch for drugs/clinical trials and news about BRD7 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BRD7 gene (2 alternative transcripts): 
    NM_001173984.2  NM_013263.4  

    Unigene Cluster for BRD7:

    Bromodomain containing 7
    Hs.437894  [show with all ESTs]
    Unigene Representative Sequence: NM_001173984
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000562383 ENST00000569774 ENST00000394688(uc021thx.1 uc002ege.2)
    ENST00000394689 ENST00000475877 ENST00000401491 ENST00000567826

    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate BRD7:
    hsa-miR-520d-5p hsa-miR-889 hsa-miR-524-5p hsa-miR-556-3p hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmidBRD7 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AF152604.1 AF213969.1 AJ271881.1 AK027308.1 AK074613.1 BC001611.1 BC050728.1 BC094706.1 

    15 DOTS entries:

    DT.100791331  DT.454106  DT.451852  DT.97776225  DT.120916829  DT.120916851  DT.120656760  DT.100703997 
    DT.120656775  DT.95261691  DT.99997198  DT.100756739  DT.40232112  DT.75139342  DT.95220138 

    24/303 AceView cDNA sequences (see all 303):

    BM977539 BM984939 BU622055 AI950064 BM985285 BC001611 AW004710 AA235012 
    BQ775186 AA740455 AA732013 BU627954 BU631142 CA442476 CA437083 BQ011126 
    BQ686403 AA961864 AI433530 N25720 AF152604 AK027308 CR593793 BM669874 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BRD7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAAACAACT
    BRD7 Expression
    About this image
    See BRD7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BRD7

    SOURCE GeneReport for Unigene cluster: Hs.437894
        SABiosciences Expression via Pathway-Focused PCR Array including BRD7: 

              Epigenetic Chromatin Remodeling Factors in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for BRD7 gene from 8/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves BRD71 bromodomain containing 7 75.97(n)
    79.22(a)
      415730  NM_001005839.1  NP_001005839.1 
    lizard
    (Anolis carolinensis)
    Reptilia BRD76
    --
    73(a)
    1 ↔ 1
    GL343227.1(1686849-1704396)
    African clawed frog
    (Xenopus laevis)
    Amphibia BRD72 nuclear transcriptor-like protein 74.67(n)    AY256967.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.238942 Danio rerio cDNA clone MGC66347 IMAGE5604192, complete more 74.5(n)    BC055611.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG71541 CG7154 45.66(n)
    35.81(a)
      34062  NM_135304.2  NP_609148.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tag-2981 Protein TAG-298 45.35(n)
    31.12(a)
      172461  NM_059640.5  NP_492041.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G763806
    AT1G206706
    (see all 3)
    DNA-binding bromodomain-containing protein
    (see all 3)
    13(a)
    12(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    1(28651154-28654580)
    1(7164190-7168021)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 3)
    bromodomain domain containing protein, expressed
    DNA-binding bromodomain-containing protein, putati...
    (see all 3)
    12(a)
    11(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    9(21751268-21757050)
    3(1751156-1757214)


    ENSEMBL Gene Tree for BRD7 (if available)
    TreeFam Gene Tree for BRD7 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BRD7 gene
    BRD92  
    2 SIMAP similar genes for BRD7 using alignment to 3 protein entries:     BRD7_HUMAN (see all proteins):
    FT002    BRD9

    BRD7 for paralogs           About GeneDecksing


    5/8 Pseudogenes.org Pseudogenes for BRD7 (see all 8)
    PGOHUM00000248464 PGOHUM00000248110 PGOHUM00000240674 PGOHUM00000238129 PGOHUM00000238245


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/983 NCBI SNPs in BRD7 are shown (see all 983    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs762597461,2
    F--36241227(+) GACTAC/GGCGCA 2 -- int11Minor allele frequency- G:0.03NA 120
    rs727862651,2
    C,F--36241623(+) AAATCC/TGAGGT 2 -- int14Minor allele frequency- T:0.20NA WA 126
    rs1138624801,2
    F--36242352(+) AACACG/ACCATA 2 -- int11Minor allele frequency- A:0.50CSA 4
    rs99223621,2
    C,F,H--36243648(+) GATATG/ACATTT 2 -- int119Minor allele frequency- A:0.11NS EA NA WA 2392
    rs1136432971,2
    F--36243682(+) CCTCAC/TAACTC 2 -- int11Minor allele frequency- T:0.50CSA 4
    rs780160531,2
    F--36244276(+) AATGTG/CAAAGC 2 -- int11Minor allele frequency- C:0.06WA 118
    rs620299631,2
    C--36244327(+) AGAGAC/TAAATA 2 -- int12Minor allele frequency- T:0.12NA 122
    rs753282801,2
    F--36244608(+) AAATAT/CGTATT 2 -- int11Minor allele frequency- C:0.16WA 118
    rs669733811,2
    C,F--36244951(+) CTCCAA/GCTGAA 2 -- int14Minor allele frequency- G:0.20NA WA 126
    rs1130764681,2
    F--36245745(+) AGTGAC/TGGGTG 2 -- int11Minor allele frequency- T:0.50CSA 4

    HapMap Linkage Disequilibrium report for BRD7 (50347398 - 50402845 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for BRD7: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BRD7
    DNA2.0 Custom Variant and Variant Library Synthesis for BRD7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    BRD7 for disorders           About GeneDecksing

    7 diseases for BRD7:    About MalaCards
    nasopharynx carcinoma    huntington's disease    acute leukemia    nasopharyngitis
    colorectal cancer    leukemia    carcinoma

    1 disease from the University of Copenhagen DISEASES database for BRD7:
    Nasopharynx carcinoma

    1 Novoseek disease relationship for BRD7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 3 12918109 (2), 19949542 (1)

    Human Genome Epidemiology (HuGE) Navigator: BRD7 (1 document)

    Export disorders for BRD7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BRD7 gene, integrated from 9 sources (see all 58):
    (articles sorted by number of sources associating them with BRD7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. BRD7 is a candidate tumour suppressor gene required f or p53 function. (PubMed id 20228809)1, 2, 9 Drost J....Del Sal G. (2010)
    2. Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2. (PubMed id 11025449)1, 2, 9 Staal A.... van Wijnen A.J. (2000)
    3. Identification and molecular characterization of BP75, a novel bromodomain-containing protein. (PubMed id 10526152)1, 3, 9 Cuppen E....Hendriks W. (1999)
    4. Polybromo-associated BRG1-associated factor component s BRD7 and BAF180 are critical regulators of p53 required for induction of repl icative senescence. (PubMed id 20660729)1, 2 Burrows A.E....Elledge S.J. (2010)
    5. BRD7, a subunit of SWI/SNF complexes, binds directly to BRCA1 and regulates BRCA1-dependent transcription. (PubMed id 20215511)1, 2 Harte M.T....Harkin D.P. (2010)
    6. BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells. (PubMed id 18809673)1, 3 Kaeser M.D....Emerson B.M. (2008)
    7. The transcriptional regulation role of BRD7 by binding to acetylated histone through bromodomain. (PubMed id 16265664)1, 2 Peng C....Li G.Y. (2006)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    9. Identification of nuclear localization signal that governs nuclear import of BRD7 and its essential roles in inhibiting cell cycle progression. (PubMed id 16475162)1, 2 Zhou M....Li G. (2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29117 HGNC: 14310 AceView: BRD7 Ensembl:ENSG00000166164 euGenes: HUgn29117
    ECgene: BRD7 H-InvDB: BRD7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BRD7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BRD7 gene:
    Search GeneIP for patents involving BRD7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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