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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BRD7 Gene

protein-coding   GIFtS: 52
GCID: GC16M050352

Bromodomain Containing 7

(Previous name: bromodomain-containing 7)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Bromodomain Containing 71 2     CELTIX12 3
Protein CELTIX-12 3     Bromodomain-Containing 71
75 KDa Bromodomain Protein2 3     NAG42
BP752 3     Bromodomain-Containing Protein 72

External Ids:    HGNC: 143101   Entrez Gene: 291172   Ensembl: ENSG000001661647   UniProtKB: Q9NPI13   

Export aliases for BRD7 gene to outside databases

Previous GC identifers: GC16M040766 GC16M050400 GC16M050088 GC16M050130 GC16M048910 GC16M036240


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BRD7 Gene:
This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this
gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein
which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor
growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in
multiple transcript variants. (provided by RefSeq, Jul 2010)

GeneCards Summary for BRD7 Gene: 
BRD7 (bromodomain containing 7) is a protein-coding gene. Diseases associated with BRD7 include nasopharynx carcinoma, and nasopharyngitis, and among its related super-pathways are Wnt signaling pathway. GO annotations related to this gene include transcription corepressor activity and transcription factor binding. An important paralog of this gene is BRD9.

UniProtKB/Swiss-Prot: BRD7_HUMAN, Q9NPI1
Function: Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the
Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity.
Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional
activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes.
Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1
promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of
transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene
activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to
target promoters. Inhibits cell cycle progression from G1 to S phase

Gene Wiki entry for BRD7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BRD7 gene promoter:
         Max   AhR   RP58   HSF2   NRSF form 1   NRSF form 2   c-Myc   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBRD7 promoter sequence
   Search SABiosciences Chromatin IP Primers for BRD7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BRD7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q12   Ensembl cytogenetic band:  16q12.1   HGNC cytogenetic band: 16q12.1

BRD7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRD7 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M050352:  view genomic region     (about GC identifiers)

Start:
50,347,398 bp from pter      End:
50,402,845 bp from pter
Size:
55,448 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BRD7_HUMAN, Q9NPI1 (See protein sequence)
Recommended Name: Bromodomain-containing protein 7  
Size: 651 amino acids; 74139 Da
Subunit: Interacts with TRIM24, PTPN13 and DVL1. Identified in a complex with SMARCA4/BRG1, SMARCC1/BAF155,
SMARCE1/BAF57, DPF2/BAF45D and ARID2, subunits of the SWI/SNF-B (PBAF) chromatin remodeling complex (By
similarity). Interacts with IRF2 and HNRPUL1. Interacts (via N-terminus) with TP53. Interacts (via C-terminus)
with EP300. Interacts with BRCA1. Interacts (via bromo domain) with histone H3 (via N-terminus) acetylated at
'Lys-14' (H3K14ac). Has low affinity for histone H3 acetylated at 'Lys-9' (H3K9ac). Has the highest affinity for
histone H3 that is acetylated both at 'Lys-9' (H3K9ac) and at 'Lys-14' (H3K14ac). Has very low affinity for
non-acetylated histone H3. Interacts (via bromo domain) with histone H4 (via N-terminus) acetylated at 'Lys-8'
(H3K8ac) (in vitro)
Subcellular location: Isoform 2: Nucleus
Sequence caution: Sequence=AAH01611.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB55031.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAC11089.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for BRD7:
2I7K (3D)    
Secondary accessions: Q4VC09 Q8N2L9 Q96KA4 Q9BV48 Q9UH59
Alternative splicing: 2 isoforms:  Q9NPI1-1   Q9NPI1-2   

Explore the universe of human proteins at neXtProt for BRD7: NX_Q9NPI1

Explore proteomics data for BRD7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NPI1

  • BRD7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BRD7 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001167455.1  NP_037395.2  

    ENSEMBL proteins: 
     ENSP00000458430   ENSP00000461556   ENSP00000378180   ENSP00000378181  

    Human Recombinant Protein Products for BRD7: 
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    Novus Biologicals BRD7 Protein
    Novus Biologicals BRD7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BRD7 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11025449
    GO:0005737cytoplasm TAS10526152

    BRD7 for ontologies           About GeneDecksing



    BRD7 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for BRD7 
    Cloud-Clone Corp. CLIAs for BRD7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR001487 Bromodomain
     IPR021900 DUF3512

    Graphical View of Domain Structure for InterPro Entry Q9NPI1

    ProtoNet protein and cluster: Q9NPI1

    1 Blocks protein domain: IPB001487 Bromodomain signature

    UniProtKB/Swiss-Prot: BRD7_HUMAN, Q9NPI1
    Similarity: Contains 1 bromo domain


    BRD7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BRD7_HUMAN, Q9NPI1
    Function: Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the
    Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity.
    Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional
    activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes.
    Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1
    promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of
    transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene
    activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to
    target promoters. Inhibits cell cycle progression from G1 to S phase

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IPI--
    GO:0003713transcription coactivator activity IDA--
    GO:0003714transcription corepressor activity ISS--
    GO:0005515protein binding IPI12489984
    GO:0008134transcription factor binding IDA11025449
         
    BRD7 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Brd7):
     integument  mortality/aging  nervous system 

    BRD7 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for BRD7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BRD7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BRD7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BRD7 

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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate BRD7:
    hsa-miR-520d-5p hsa-miR-889 hsa-miR-524-5p hsa-miR-556-3p hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmidBRD7 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRD7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BRD7 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway
    Wnt Signaling Pathway NetPath0.37


    1 BioSystems Pathway for BRD7
        Wnt Signaling Pathway NetPath


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BRD7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/640 Interacting proteins for BRD7 (Q9NPI11, 2, 3 ENSP000003781804) via UniProtKB, MINT, STRING, and/or I2D (see all 640)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628052, 3, ENSP000003529804MINT-6665465 I2D: score=3 STRING: ENSP00000352980
    HIST1H4LP628052, 3, ENSP000003482584MINT-6665465 I2D: score=3 STRING: ENSP00000348258
    HIST1H4BP628052, 3MINT-6665465 I2D: score=3 
    HIST1H4CP628052, 3MINT-6665465 I2D: score=3 
    HIST1H4DP628052, 3MINT-6665465 I2D: score=3 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter IDA12489984
    GO:0007049cell cycle IEA--
    GO:0008285negative regulation of cell proliferation IDA--
    GO:0016055Wnt receptor signaling pathway IEA--

    BRD7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BRD7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BRD7

    1 Novoseek inferred chemical compound relationship for BRD7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 24.6 1 15382140 (1)

    Search CenterWatch for drugs/clinical trials and news about BRD7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BRD7 gene (2 alternative transcripts): 
    NM_001173984.2  NM_013263.4  

    Unigene Cluster for BRD7:

    Bromodomain containing 7
    Hs.437894  [show with all ESTs]
    Unigene Representative Sequence: NM_001173984
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000562383 ENST00000569774 ENST00000394688(uc021thx.1 uc002ege.2)
    ENST00000394689 ENST00000475877 ENST00000401491 ENST00000567826
    miRNA
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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate BRD7:
    hsa-miR-520d-5p hsa-miR-889 hsa-miR-524-5p hsa-miR-556-3p hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmidBRD7 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BRD7
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    Sirion Biotech Customized lentivirus for stable overexpression of BRD7 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BRD7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BRD7

    Additional mRNA sequence: 

    AF152604.1 AF213969.1 AJ271881.1 AK027308.1 AK074613.1 BC001611.1 BC050728.1 BC094706.1 

    15 DOTS entries:

    DT.100791331  DT.454106  DT.451852  DT.97776225  DT.120916829  DT.120916851  DT.120656760  DT.100703997 
    DT.120656775  DT.95261691  DT.99997198  DT.100756739  DT.40232112  DT.75139342  DT.95220138 

    24/303 AceView cDNA sequences (see all 303):

    BQ011423 NM_013263 AA488428 AI056857 BM460725 AA740455 BM985285 BQ686403 
    CA312534 AI358382 CA442476 AA353892 BE207935 AA693807 AA948532 AW004710 
    AF152604 AA235012 BQ775186 BE222661 BE531153 BG031737 BI438648 AA732013 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BRD7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAACAACT
    BRD7 Expression
    About this image


    See BRD7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BRD7

    SOURCE GeneReport for Unigene cluster: Hs.437894
        SABiosciences Expression via Pathway-Focused PCR Array including BRD7: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for BRD7 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Brd71 , 5 bromodomain containing 71, 5 87.35(n)1
    88.17(a)1
      8 (43.07 cM)5
    269921  NM_012047.21  NP_036177.11 
     883310395 
    chicken
    (Gallus gallus)
    Aves BRD71 bromodomain containing 7 75.97(n)
    79.22(a)
      415730  NM_001005839.1  NP_001005839.1 
    lizard
    (Anolis carolinensis)
    Reptilia BRD76
    bromodomain containing 7
    72(a)
    1 ↔ 1
    GL343227.1(1686859-1704416)
    African clawed frog
    (Xenopus laevis)
    Amphibia BRD72 nuclear transcriptor-like protein 74.67(n)    AY256967.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.238942 Danio rerio cDNA clone MGC66347 IMAGE5604192, complete more 74.5(n)    BC055611.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG71541 CG7154 45.66(n)
    35.81(a)
      34062  NM_135304.2  NP_609148.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tag-2981 Protein TAG-298 45.35(n)
    31.12(a)
      172461  NM_059640.5  NP_492041.1 


    ENSEMBL Gene Tree for BRD7 (if available)
    TreeFam Gene Tree for BRD7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BRD7 gene
    BRD92  
    2 SIMAP similar genes for BRD7 using alignment to 3 protein entries:     BRD7_HUMAN (see all proteins):
    FT002    BRD9

    BRD7 for paralogs           About GeneDecksing


    5/8 Pseudogenes.org Pseudogenes for BRD7 (see all 8)
    PGOHUM00000248464 PGOHUM00000248110 PGOHUM00000240674 PGOHUM00000238129 PGOHUM00000238245


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1204 SNPs in BRD7 are shown (see all 1204)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1428315431,2
    --36259053(+) TTCTT-/CTTTTT 2 -- int10--------
    rs105691821,2
    C--36262974(+) TAAGT-/ACacaca 2 -- int10--------
    rs774692841,2
    --36273644(+) TCGGTA/GTATCC 2 -- int11Minor allele frequency- G:0.00CSA 1
    rs785332271,2
    C,F--36273696(+) AATCAG/AGGTAA 2 -- int12Minor allele frequency- A:0.50NA WA 4
    rs347147811,2
    C--36274520(+) CTTTG-/G/TTTTTT 2 -- int12NA 4
    rs583561441,2
    C--36278539(+) AAAAA-/TATATA 2 -- int10--------
    rs1390259031,2
    C--36278539(+) AAAAA-/AATATATA 2 -- int10--------
    rs670321241,2
    C--36278541(+) AAAAA-/TTATAT 2 -- int10--------
    rs1511514321,2
    C--36290925(+) CTGCGC/GGTGGC 2 -- us2k10--------
    rs50012421,2
    --36290972(+) ggccgA/Ggggcg 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for BRD7 (50347398 - 50402845 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for BRD7:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv1806CNV Insertion18451855
    nsv1805CNV Loss18451855
    esv1011295OTHER Inversion20482838

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    6 diseases for BRD7:    About MalaCards
    nasopharynx carcinoma    nasopharyngitis    acute leukemia    colorectal cancer
    lung cancer    leukemia

    1 disease from the University of Copenhagen DISEASES database for BRD7:
    Nasopharynx carcinoma

    BRD7 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for BRD7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 3 12918109 (2), 19949542 (1)

    Genetic Association Database (GAD): BRD7
    Human Genome Epidemiology (HuGE) Navigator: BRD7 (1 document)

    Export disorders for BRD7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BRD7 gene, integrated from 9 sources (see all 61):
    (articles sorted by number of sources associating them with BRD7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. BRD7 is a candidate tumour suppressor gene required f or p53 function. (PubMed id 20228809)1, 2, 9 Drost J....Del Sal G. (2010)
    2. Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2. (PubMed id 11025449)1, 2, 9 Staal A.... van Wijnen A.J. (2000)
    3. Identification and molecular characterization of BP75, a novel bromodomain-containing protein. (PubMed id 10526152)1, 3, 9 Cuppen E....Hendriks W. (1999)
    4. Polybromo-associated BRG1-associated factor component s BRD7 and BAF180 are critical regulators of p53 required for induction of repl icative senescence. (PubMed id 20660729)1, 2 Burrows A.E....Elledge S.J. (2010)
    5. BRD7, a subunit of SWI/SNF complexes, binds directly to BRCA1 and regulates BRCA1-dependent transcription. (PubMed id 20215511)1, 2 Harte M.T....Harkin D.P. (2010)
    6. BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells. (PubMed id 18809673)1, 3 Kaeser M.D....Emerson B.M. (2008)
    7. [Expression and SNP analysis of BRD7 gene in acute leukemia cells] (PubMed id 18772500)1, 4 Tang X.Y....Shen S.R. (2008)
    8. The transcriptional regulation role of BRD7 by binding to acetylated histone through bromodomain. (PubMed id 16265664)1, 2 Peng C....Li G.Y. (2006)
    9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    10. Identification of nuclear localization signal that governs nuclear import of BRD7 and its essential roles in inhibiting cell cycle progression. (PubMed id 16475162)1, 2 Zhou M....Li G. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29117 HGNC: 14310 AceView: BRD7 Ensembl:ENSG00000166164 euGenes: HUgn29117
    ECgene: BRD7 H-InvDB: BRD7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BRD7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BRD7 gene:
    Search GeneIP for patents involving BRD7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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