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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BRD3 Gene

protein-coding   GIFtS: 58
GCID: GC09M136897

Bromodomain Containing 3

(Previous name: bromodomain-containing 3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Bromodomain Containing 31 2     ORFX2 5
RING3L2 3 5     RING3-like1
Bromodomain-Containing 31 2     Bromodomain-Containing Protein 32
RING3-Like Protein2 3     KIAA00433

External Ids:    HGNC: 11041   Entrez Gene: 80192   Ensembl: ENSG000001699257   OMIM: 6015415   UniProtKB: Q150593   

Export aliases for BRD3 gene to outside databases

Previous GC identifers: GC09M127972 GC09M128566 GC09M130323 GC09M132239 GC09M133927 GC09M135886 GC09M106393


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BRD3 Gene:
This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase.
The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The
function of the encoded protein is not known. (provided by RefSeq, Jul 2008)

GeneCards Summary for BRD3 Gene: 
BRD3 (bromodomain containing 3) is a protein-coding gene. Diseases associated with BRD3 include nasopharyngitis, and endotheliitis. GO annotations related to this gene include histone acetyl-lysine binding and molecular_function. An important paralog of this gene is BRDT.

UniProtKB/Swiss-Prot: BRD3_HUMAN, Q15059
Function: Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by
chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding
of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene

Gene Wiki entry for BRD3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_035014.4  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BRD3 gene promoter:
         AhR   Pax-5   AML1a   RelA   Cdc5   Evi-1   Max   c-Myb   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBRD3 promoter sequence
   Search SABiosciences Chromatin IP Primers for BRD3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BRD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34   Ensembl cytogenetic band:  9q34.2   HGNC cytogenetic band: 9q34

BRD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRD3 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M136897:  view genomic region     (about GC identifiers)

Start:
136,895,427 bp from pter      End:
136,933,657 bp from pter
Size:
38,231 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BRD3_HUMAN, Q15059 (See protein sequence)
Recommended Name: Bromodomain-containing protein 3  
Size: 726 amino acids; 79542 Da
Subunit: Interacts (via bromo domain 1) with GATA1 acetylated at 'Lys-312' and 'Lys-315'. Interacts (via bromo
domain 1) with GATA2 acetylated on lysine residues (By similarity). Interacts (via bromo domains) with acetylated
lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (in vitro)
Subcellular location: Nucleus (Probable). Note=Detected on chromatin (By similarity)
Sequence caution: Sequence=BAA05393.2; Type=Erroneous initiation;
6 PDB 3D structures from and Proteopedia for BRD3:
2E7N (3D)        2NXB (3D)        2OO1 (3D)        2YW5 (3D)        3S91 (3D)        3S92 (3D)    
Secondary accessions: B1APD9 Q4G5Y3 Q5T1R7 Q8N5M3 Q92645
Alternative splicing: 2 isoforms:  Q15059-1   Q15059-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BRD3: NX_Q15059

Explore proteomics data for BRD3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15059

  • BRD3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BRD3 Protein Expression
    REFSEQ proteins: NP_031397.1  
    ENSEMBL proteins: 
     ENSP00000305918   ENSP00000360900   ENSP00000360908   ENSP00000406749   ENSP00000350557  

    Human Recombinant Protein Products for BRD3: 
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    Novus Biologicals BRD3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BRD3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--

    BRD3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR018359 Bromodomain_CS
     IPR027353 NET_dom
     IPR001487 Bromodomain

    Graphical View of Domain Structure for InterPro Entry Q15059

    ProtoNet protein and cluster: Q15059

    1 Blocks protein domain: IPB001487 Bromodomain signature

    UniProtKB/Swiss-Prot: BRD3_HUMAN, Q15059
    Similarity: Contains 2 bromo domains
    Similarity: Contains 1 NET domain


    BRD3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BRD3_HUMAN, Q15059
    Function: Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by
    chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding
    of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003682chromatin binding IDA18406326
    GO:0005515protein binding IPI--
    GO:0070577histone acetyl-lysine binding IDA--
         
    BRD3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for BRD3:
     Decreased substrate adherent c  Increased cell death HMECs cel 

         1 MGI phenotypic allele for Brd3 (no phenotypes)

    BRD3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for BRD3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BRD3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BRD3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BRD3 

    miRNA
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    miRTarBase miRNAs that target BRD3:
    hsa-mir-192 (MIRT004162), hsa-mir-141 (MIRT003279)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BRD3
    8/94 QIAGEN miScript miRNA Assays for microRNAs that regulate BRD3 (see all 94):
    hsa-miR-548j hsa-miR-582-3p hsa-miR-485-3p hsa-miR-200a hsa-miR-3653 hsa-miR-10b* hsa-miR-1304 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidBRD3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRD3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BRD3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/6 Interacting proteins for BRD3 (Q150591, 2, 3 ENSP000003059184) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP1LC3BQ9GZQ82, 3MINT-8259492 I2D: score=2 
    MYCP011061, 3EBI-1383460,EBI-447544 I2D: score=1 
    BRD7Q9NPI13, ENSP000003781804I2D: score=1 STRING: ENSP00000378180
    JUNP054123I2D: score=2 
    BRD4ENSP000002633774STRING: ENSP00000263377
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter IDA18406326
    GO:0008150biological_process ND--
    GO:0016568chromatin modification IEA--

    BRD3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BRD3

    Search CenterWatch for drugs/clinical trials and news about BRD3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BRD3 gene: 
    NM_007371.3  

    Unigene Clusters for BRD3:

    Bromodomain containing 3
    Hs.522472  [show with all ESTs], Hs.654869  [show with all ESTs]
    Unigene Representative Sequences: NM_007371, NR_015427
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000303407(uc004cew.3) ENST00000473349 ENST00000371834(uc004cex.2)
    ENST00000494743 ENST00000371842 ENST00000433041 ENST00000357885
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BRD3
    8/94 QIAGEN miScript miRNA Assays for microRNAs that regulate BRD3 (see all 94):
    hsa-miR-548j hsa-miR-582-3p hsa-miR-485-3p hsa-miR-200a hsa-miR-3653 hsa-miR-10b* hsa-miR-1304 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidBRD3 3' UTR sequence
    Inhib. RNA
    Products:
         
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    OriGene RNAi products in human, mouse, rat for BRD3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BRD3
    Clone
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    GenScript: all cDNA clones in your preferred vector: BRD3 (NM_007371)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRD3
    Sirion Biotech Customized lentivirus for stable overexpression of BRD3 
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    OriGene qSTAR qPCR primer pairs in human, mouse for BRD3
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BRD3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BRD3

    Additional mRNA sequence: 

    AK092667.1 AK123322.1 AY203934.1 BC053543.1 BC065204.1 BC094875.1 BC108326.1 NR_015427.2 

    21 DOTS entries:

    DT.414124  DT.445025  DT.446882  DT.95267338  DT.100783534  DT.414125  DT.92424044  DT.95267333 
    DT.92053916  DT.121185294  DT.95267339  DT.100719742  DT.100776193  DT.100776200  DT.121185253  DT.121185261 
    DT.40107370  DT.91701327  DT.92424047  DT.97844700  DT.97855871 

    24/336 AceView cDNA sequences (see all 336):

    AI222850 BM875495 AA351220 AI348289 BG108973 AA988348 BG258528 AW469092 
    AI621070 AK123322 AI345989 BU740912 BU783123 AW674751 BF057645 AA580528 
    AA464610 BM714382 AI652521 AI208725 BU071294 AA831126 BU625549 AI346776 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BRD3 expression in normal human tissues (normalized intensities)      BRD3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    BRD3 Expression
    About this image


    BRD3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             superior temporal gyrus   
     
     Testis (Reproductive System)
             Testis Somatic Cells Primitive Gonad
     
     Gonad (Reproductive System)
             Testis Somatic Cells Primitive Gonad

    See BRD3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BRD3

    SOURCE GeneReport for Unigene clusters: Hs.522472 Hs.654869

    UniProtKB/Swiss-Prot: BRD3_HUMAN, Q15059
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Array including BRD3: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRD3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for BRD3 gene from 8/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Brd31 , 5 bromodomain containing 31, 5 88.31(n)1
    95.86(a)1
      2 (19.38 cM)5
    673821  NM_023336.41  NP_075825.31 
     274455795 
    chicken
    (Gallus gallus)
    Aves BRD31 bromodomain containing 3 81.3(n)
    91.97(a)
      427757  XM_425330.3  XP_425330.2 
    lizard
    (Anolis carolinensis)
    Reptilia BRD36
    bromodomain containing 3
    85(a)
    1 ↔ 1
    GL343736.1(32014-70163)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL965484.22   -- 79.03(n)    AL965484.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc56a112 Danio rerio cDNA clone IMAGE5604925, partial cds 79.51(n)    BC055533.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fs(1)h1 , 3 regulation of transcription from Pol II
    promoter more3
    female sterile (1) homeotic1
    56(a)3
    57.22(n)1
    54.79(a)1
      317221  NM_078523.21  NP_511078.21 
    worm
    (Caenorhabditis elegans)
    Secernentea bet-11 Protein BET-1 44.44(n)
    34.94(a)
      172054  NM_058983.2  NP_491384.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes BDF11 Bdf1p 44.03(n)
    33.58(a)
      851115   NP_013503.1 


    ENSEMBL Gene Tree for BRD3 (if available)
    TreeFam Gene Tree for BRD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BRD3 gene
    BRDT2  BRD42  CREBBP2  BRD22  EP3002  
    5 SIMAP similar genes for BRD3 using alignment to 4 protein entries:     BRD3_HUMAN (see all proteins):
    BRDT    BRD2    BRD4    DKFZp686N0336    DKFZp313H139

    BRD3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1023 SNPs in BRD3 are shown (see all 1023)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0419134
    A renal clear cell carcinoma sample4--see VAR_0419132 T N mis40--------
    VAR_0419144
    A gastric adenocarcinoma sample4--see VAR_0419142 A T mis40--------
    rs1143670191,2
    C,F--136897221(+) TGGCCG/AGAGCC 1 -- ut311Minor allele frequency- A:0.10WA 118
    rs354117201,2
    C--136897458(+) CAGTCTT/-TTAAA 1 -- ut311Minor allele frequency- -:0.50NA 2
    rs1125750011,2
    F--136897535(+) TGTCTA/GTACCT 1 -- ut312Minor allele frequency- G:0.02CSA WA 120
    rs798896731,2
    C--136897584(+) AAAACA/CACAAA 1 -- ut310--------
    rs4438651,2
    C--136897598(+) AAAAAC/ACAAAA 1 -- ut311Minor allele frequency- A:0.50NA 2
    rs1486568921,2
    --136897694(+) CCGCCA/GCCAGA 1 -- ut310--------
    rs109938961,2
    C,F,A,H--136897709(+) ACCCGC/G/TGCCCG 2 -- ut31 ese39EA NS NA WA CSA 531
    rs2002925981,2
    --136897976(+) TTTTT-/TTAAATCT 1 -- cds10--------

    HapMap Linkage Disequilibrium report for BRD3 (136895427 - 136933657 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/18 variations for BRD3 (see all 18):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2739138CNV Deletion23290073
    dgv8343n71CNV Loss21882294
    dgv8341n71CNV Loss21882294
    nsv894132CNV Loss21882294
    nsv831749CNV Loss17160897
    dgv8339n71CNV Loss21882294
    nsv428226CNV Loss18775914
    nsv894152CNV Loss21882294
    nsv466629CNV Loss19166990
    nsv831748CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601541    OMIM disorders: --

    UniProtKB/Swiss-Prot: BRD3_HUMAN, Q15059
  • Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising
    in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion
    protein

  • 2 diseases for BRD3:    About MalaCards
    nasopharyngitis    endotheliitis


    BRD3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): BRD3

    Export disorders for BRD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BRD3 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with BRD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)1, 2, 3 Nomura N....Tabata S. (1994)
    2. Chromosomal localization, gene structure and transcription pattern of the ORFX gene, a homologue of the MHC-linked RING3 gene. (PubMed id 9373153)1, 2, 9 Thorpe K.L.... Beck S. (1997)
    3. New gene functions in megakaryopoiesis and platelet fo rmation. (PubMed id 22139419)1, 4 Gieger C....Soranzo N. (2011)
    4. The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription. (PubMed id 18406326)1, 2 LeRoy G....Flint S.J. (2008)
    5. BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells. (PubMed id 17934517)1, 2 French C.A.... Aster J.C. (2008)
    6. Differentially expressed genes in endothelial differentiation. (PubMed id 16008511)1, 2 Ishii H.... Vecchione A. (2005)
    7. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Phylogeny and structure of the RING3 gene. (PubMed id 8781126)1, 3 Thorpe K.L....Beck S. (1996)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8019 HGNC: 1104 AceView: BRD3 Ensembl:ENSG00000169925 euGenes: HUgn8019
    ECgene: BRD3 H-InvDB: BRD3

    (According to HUGE)
    About This Section
    HUGE: KIAA0043

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BRD3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BRD3 gene:
    Search GeneIP for patents involving BRD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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