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Aliases for BRD3 Gene

Aliases for BRD3 Gene

  • Bromodomain Containing 3 2 3
  • RING3L 3 4 6
  • Bromodomain-Containing 3 2 3
  • RING3-Like Protein 3 4
  • ORFX 3 6
  • Bromodomain-Containing Protein 3 3
  • RING3-Like 2
  • KIAA0043 4

External Ids for BRD3 Gene

Previous GeneCards Identifiers for BRD3 Gene

  • GC09M127972
  • GC09M128566
  • GC09M130323
  • GC09M132239
  • GC09M133927
  • GC09M135886
  • GC09M136897
  • GC09M106393

Summaries for BRD3 Gene

Entrez Gene Summary for BRD3 Gene

  • This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for BRD3 Gene

BRD3 (Bromodomain Containing 3) is a Protein Coding gene. GO annotations related to this gene include chromatin binding and lysine-acetylated histone binding. An important paralog of this gene is BRD4.

UniProtKB/Swiss-Prot for BRD3 Gene

  • Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene.

Gene Wiki entry for BRD3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRD3 Gene

Genomics for BRD3 Gene

Regulatory Elements for BRD3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BRD3 Gene

Start:
134,030,305 bp from pter
End:
134,068,535 bp from pter
Size:
38,231 bases
Orientation:
Minus strand

Genomic View for BRD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BRD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRD3 Gene

Proteins for BRD3 Gene

  • Protein details for BRD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15059-BRD3_HUMAN
    Recommended name:
    Bromodomain-containing protein 3
    Protein Accession:
    Q15059
    Secondary Accessions:
    • B1APD9
    • Q4G5Y3
    • Q5T1R7
    • Q8N5M3
    • Q92645

    Protein attributes for BRD3 Gene

    Size:
    726 amino acids
    Molecular mass:
    79542 Da
    Quaternary structure:
    • Interacts (via bromo domain 1) with GATA1 acetylated at Lys-312 and Lys-315. Interacts (via bromo domain 1) with GATA2 acetylated on lysine residues (By similarity). Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (in vitro).
    SequenceCaution:
    • Sequence=BAA05393.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BRD3 Gene

    Alternative splice isoforms for BRD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BRD3 Gene

Proteomics data for BRD3 Gene at MOPED

Post-translational modifications for BRD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BRD3 Gene

No data available for DME Specific Peptides for BRD3 Gene

Domains for BRD3 Gene

Protein Domains for BRD3 Gene

Suggested Antigen Peptide Sequences for BRD3 Gene

Graphical View of Domain Structure for InterPro Entry

Q15059

UniProtKB/Swiss-Prot:

BRD3_HUMAN :
  • Q15059
Domain:
  • Contains 2 bromo domains.
  • Contains 1 NET domain.
genes like me logo Genes that share domains with BRD3: view

No data available for Gene Families for BRD3 Gene

Function for BRD3 Gene

Molecular function for BRD3 Gene

UniProtKB/Swiss-Prot Function: Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene.

Gene Ontology (GO) - Molecular Function for BRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 18406326
GO:0005515 protein binding IPI 20195357
GO:0070577 lysine-acetylated histone binding IDA 22464331
genes like me logo Genes that share ontologies with BRD3: view

Phenotypes for BRD3 Gene

genes like me logo Genes that share phenotypes with BRD3: view

Animal Model Products

CRISPR Products

miRNA for BRD3 Gene

miRTarBase miRNAs that target BRD3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BRD3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for BRD3 Gene

Localization for BRD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRD3 Gene

Nucleus. Note=Detected on chromatin. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BRD3 Gene COMPARTMENTS Subcellular localization image for BRD3 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for BRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with BRD3: view

Pathways for BRD3 Gene

SuperPathways for BRD3 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for BRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IDA 18406326
GO:0016568 chromatin modification IEA --
genes like me logo Genes that share ontologies with BRD3: view

No data available for Pathways by source for BRD3 Gene

Compounds for BRD3 Gene

(11) ApexBio Compounds for BRD3 Gene

Compound Action Cas Number
(-)-JQ1 Inactive stereoisomer of bromodomain inhibitor (+)-JQ1 [1268524-71-5]
(+)-JQ1 BET bromodomain inhibitor [1268524-70-4]
Bromosporine broad spectrum inhibitor for bromodomains
I-BET151 (GSK1210151A) BET bromodomain inhibitor(pIC50=6.1,BRD4) [1300031-49-5]
I-BET-762 inhibitor for BET proteins [1260907-17-2]
OTX-015 new potent BRD-inhibitor [202590-98-5]
PFI-1 (PF-6405761) selective BET inhibitor for BRD4 [1403764-72-6]
RVX-208 potent BET bromodomain inhibitor for BD2 [1044870-39-4]
SGC-CBP30 Potent CREBBP/EP300 bromodomain inhibitor
UNC1215 elective MBT antagonist [1415800-43-9]
UNC669 potent and selective MBT inhibitor [1314241-44-5]
genes like me logo Genes that share compounds with BRD3: view

Transcripts for BRD3 Gene

Unigene Clusters for BRD3 Gene

Bromodomain containing 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BRD3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for BRD3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BRD3 Gene

No ASD Table

Relevant External Links for BRD3 Gene

GeneLoc Exon Structure for
BRD3
ECgene alternative splicing isoforms for
BRD3

Expression for BRD3 Gene

mRNA expression in normal human tissues for BRD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BRD3 Gene

SOURCE GeneReport for Unigene cluster for BRD3 Gene Hs.522472

mRNA Expression by UniProt/SwissProt for BRD3 Gene

Q15059-BRD3_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with BRD3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for BRD3 Gene

Orthologs for BRD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for BRD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BRD3 35
  • 99.36 (n)
  • 99.72 (a)
BRD3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BRD3 35
  • 88.68 (n)
  • 93.32 (a)
BRD3 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BRD3 35
  • 89.93 (n)
  • 94.68 (a)
BRD3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Brd3 35
  • 87.81 (n)
  • 95 (a)
Brd3 16
Brd3 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BRD3 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BRD3 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Brd3 35
  • 88.02 (n)
  • 95.29 (a)
chicken
(Gallus gallus)
Aves BRD3 35
  • 81.17 (n)
  • 92.33 (a)
BRD3 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BRD3 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia brd3 35
  • 74.65 (n)
  • 83.45 (a)
zebrafish
(Danio rerio)
Actinopterygii brd3a 35
  • 69.21 (n)
  • 76.82 (a)
brd3a 36
  • 75 (a)
OneToOne
wufc56a11 35
fruit fly
(Drosophila melanogaster)
Insecta fs(1)h 36
  • 18 (a)
OneToMany
fs(1)h 37
  • 56 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2782 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToMany
Species with no ortholog for BRD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRD3 Gene

ENSEMBL:
Gene Tree for BRD3 (if available)
TreeFam:
Gene Tree for BRD3 (if available)

Paralogs for BRD3 Gene

Paralogs for BRD3 Gene

Selected SIMAP similar genes for BRD3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with BRD3: view

Variants for BRD3 Gene

Sequence variations from dbSNP and Humsavar for BRD3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs14719 -- 134,032,976(-) TTCTC(C/T)GCTCG utr-variant-3-prime
rs378569 -- 134,037,293(+) AGggc(C/T)gggcg intron-variant
rs392134 -- 134,043,886(-) TGAGA(C/T)GAGCT intron-variant
rs409348 -- 134,032,536(+) GCGCG(C/G)TGGCA utr-variant-3-prime
rs416390 -- 134,043,427(-) TCTGA(C/G)CTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BRD3 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV Deletion 23290073
nsv894125 CNV Loss 21882294
dgv8337n71 CNV Loss 21882294
nsv831748 CNV Loss 17160897
nsv831749 CNV Loss 17160897
nsv894132 CNV Loss 21882294
nsv428226 CNV Loss 18775914
dgv8339n71 CNV Loss 21882294
nsv825148 CNV Gain 20364138
dgv8341n71 CNV Loss 21882294
dgv8342n71 CNV Loss 21882294
dgv8343n71 CNV Loss 21882294
nsv466627 CNV Loss 19166990
nsv894150 CNV Loss 21882294
nsv466629 CNV Loss 19166990
nsv825149 CNV Gain 20364138
nsv894152 CNV Loss 21882294
esv25492 CNV Loss 19812545

Relevant External Links for BRD3 Gene

HapMap Linkage Disequilibrium report
BRD3
Human Gene Mutation Database (HGMD)
BRD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRD3 Gene

Disorders for BRD3 Gene

UniProtKB/Swiss-Prot

BRD3_HUMAN
  • Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein.

Relevant External Links for BRD3

Genetic Association Database (GAD)
BRD3
genes like me logo Genes that share disorders with BRD3: view

Publications for BRD3 Gene

  1. Chromosomal localization, gene structure and transcription pattern of the ORFX gene, a homologue of the MHC-linked RING3 gene. (PMID: 9373153) Thorpe K.L. … Beck S. (Gene 1997) 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7584044) Nomura N. … Tabata S. (DNA Res. 1994) 2 3 4
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Differentially expressed genes in endothelial differentiation. (PMID: 16008511) Ishii H. … Vecchione A. (DNA Cell Biol. 2005) 3 4

Products for BRD3 Gene

  • Addgene plasmids for BRD3

Sources for BRD3 Gene

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