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BRD3 Gene

protein-coding   GIFtS: 57
GCID: GC09M136897

Bromodomain Containing 3

(Previous name: bromodomain-containing 3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Bromodomain Containing 31 2     ORFX2 5
RING3L2 3 5     RING3-like1
Bromodomain-Containing 31 2     Bromodomain-Containing Protein 32
RING3-Like Protein2 3     KIAA00433

External Ids:    HGNC: 11041   Entrez Gene: 80192   Ensembl: ENSG000001699257   OMIM: 6015415   UniProtKB: Q150593   

Export aliases for BRD3 gene to outside databases

Previous GC identifers: GC09M127972 GC09M128566 GC09M130323 GC09M132239 GC09M133927 GC09M135886 GC09M106393


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BRD3 Gene:
This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase.
The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The
function of the encoded protein is not known. (provided by RefSeq, Jul 2008)

GeneCards Summary for BRD3 Gene:
BRD3 (bromodomain containing 3) is a protein-coding gene. Diseases associated with BRD3 include nasopharyngitis, and hiv-1. GO annotations related to this gene include histone acetyl-lysine binding and chromatin binding. An important paralog of this gene is BRDT.

UniProtKB/Swiss-Prot: BRD3_HUMAN, Q15059
Function: Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by
chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding
of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene

Gene Wiki entry for BRD3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BRD3 gene promoter:
         AhR   Pax-5   AML1a   RelA   Cdc5   Evi-1   Max   c-Myb   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBRD3 promoter sequence
   Search Chromatin IP Primers for BRD3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BRD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34   Ensembl cytogenetic band:  9q34.2   HGNC cytogenetic band: 9q34

BRD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRD3 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M136897:  view genomic region     (about GC identifiers)

Start:
136,895,427 bp from pter      End:
136,933,657 bp from pter
Size:
38,231 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: BRD3_HUMAN, Q15059 (See protein sequence)
Recommended Name: Bromodomain-containing protein 3  
Size: 726 amino acids; 79542 Da
Subunit: Interacts (via bromo domain 1) with GATA1 acetylated at 'Lys-312' and 'Lys-315'. Interacts (via bromo
domain 1) with GATA2 acetylated on lysine residues (By similarity). Interacts (via bromo domains) with acetylated
lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (in vitro)
Sequence caution: Sequence=BAA05393.2; Type=Erroneous initiation;
6 PDB 3D structures from and Proteopedia for BRD3:
2E7N (3D)        2NXB (3D)        2OO1 (3D)        2YW5 (3D)        3S91 (3D)        3S92 (3D)    
Secondary accessions: B1APD9 Q4G5Y3 Q5T1R7 Q8N5M3 Q92645
Alternative splicing: 2 isoforms:  Q15059-1   Q15059-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BRD3: NX_Q15059

Explore proteomics data for BRD3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BRD3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_031397.1  
    ENSEMBL proteins: 
     ENSP00000305918   ENSP00000360900   ENSP00000360908   ENSP00000406749   ENSP00000350557  

    BRD3 Human Recombinant Protein Products:

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    Novus Biologicals BRD3 Proteins
    Novus Biologicals BRD3 Lysate
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for BRD3

    BRD3 Antibody Products:

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    BRD3 Assay Products:

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    Cloud-Clone Corp. ELISAs for BRD3
    Cloud-Clone Corp. CLIAs for BRD3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR027353 NET_dom
     IPR018359 Bromodomain_CS
     IPR001487 Bromodomain

    Graphical View of Domain Structure for InterPro Entry Q15059

    ProtoNet protein and cluster: Q15059

    1 Blocks protein domain: IPB001487 Bromodomain signature

    UniProtKB/Swiss-Prot: BRD3_HUMAN, Q15059
    Similarity: Contains 2 bromo domains
    Similarity: Contains 1 NET domain


    BRD3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BRD3_HUMAN, Q15059
    Function: Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by
    chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding
    of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IDA18406326
    GO:0005515protein binding IPI--
    GO:0070577histone acetyl-lysine binding IDA--
         
    BRD3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for BRD3:
     Decreased substrate adherent c  Increased cell death HMECs cel 

         1 MGI phenotypic allele for Brd3 (no phenotypes)

    BRD3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BRD3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BRD3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BRD3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BRD3

    miRNA
    Products:
        
    miRTarBase miRNAs that target BRD3:
    hsa-mir-192-5p (MIRT004162), hsa-mir-141-3p (MIRT003279), hsa-mir-26b-5p (MIRT029195)

    Block miRNA regulation of human, mouse, rat BRD3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BRD3 (see all 94):
    hsa-miR-548j hsa-miR-582-3p hsa-miR-485-3p hsa-miR-200a hsa-miR-3653 hsa-miR-10b* hsa-miR-1304 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidBRD3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for BRD3
    Predesigned siRNA for gene silencing in human, mouse, rat BRD3

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for BRD3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BRD3 (NM_007371)
    Sino Biological Human cDNA Clone for BRD3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BRD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRD3

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRD3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BRD3_HUMAN, Q15059: Nucleus (Probable). Note=Detected on chromatin (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    BRD3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including BRD3: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BRD3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BRD3 (Q150591, 2, 3 ENSP000003059184) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP1LC3BQ9GZQ82, 3MINT-8259492 I2D: score=2 
    MYCP011061, 3EBI-1383460,EBI-447544 I2D: score=1 
    BRD7Q9NPI13, ENSP000003781804I2D: score=1 STRING: ENSP00000378180
    JUNP054123I2D: score=2 
    BRD4ENSP000002633774STRING: ENSP00000263377
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter IDA18406326
    GO:0016568chromatin modification IEA--

    BRD3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for BRD3 (see all 11)     About this table
    CompoundAction CAS #
    (+)-JQ1BET bromodomain inhibitor[1268524-70-4]
    (-)-JQ1Inactive stereoisomer of bromodomain inhibitor (+)-JQ1[1268524-71-5]
    Bromosporinebroad spectrum inhibitor for bromodomains--
    I-BET-762inhibitor for BET proteins[1260907-17-2]
    I-BET151 (GSK1210151A)BET bromodomain inhibitor(pIC50=6.1,BRD4)[1300031-49-5]
    OTX-015new potent BRD-inhibitor [202590-98-5]
    PFI-1 (PF-6405761)selective BET inhibitor for BRD4[1403764-72-6]
    RVX-208potent BET bromodomain inhibitor for BD2[1044870-39-4]
    SGC-CBP30Potent CREBBP/EP300 bromodomain inhibitor--
    UNC1215elective MBT antagonist[1415800-43-9]

    Browse Tocris compounds for BRD3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for BRD3 gene: 
    NM_007371.3  

    Unigene Clusters for BRD3:

    Bromodomain containing 3
    Hs.522472  [show with all ESTs], Hs.654869  [show with all ESTs]
    Unigene Representative Sequences: NM_007371, NR_015427
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000303407(uc004cew.3) ENST00000473349 ENST00000371834(uc004cex.2)
    ENST00000494743 ENST00000371842 ENST00000433041 ENST00000357885
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat BRD3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BRD3 (see all 94):
    hsa-miR-548j hsa-miR-582-3p hsa-miR-485-3p hsa-miR-200a hsa-miR-3653 hsa-miR-10b* hsa-miR-1304 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidBRD3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for BRD3
    Predesigned siRNA for gene silencing in human, mouse, rat BRD3
    Clone
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    OriGene clones in human, mouse for BRD3 (see all 6)
    OriGene ORF clones in mouse, rat for BRD3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BRD3 (NM_007371)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BRD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRD3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for BRD3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BRD3
      QuantiTect SYBR Green Assays in human, mouse, rat BRD3
      QuantiFast Probe-based Assays in human, mouse, rat BRD3

    Additional mRNA sequence: 

    AK092667.1 AK123322.1 AY203934.1 BC053543.1 BC065204.1 BC094875.1 BC108326.1 NR_015427.2 

    21 DOTS entries:

    DT.414124  DT.445025  DT.446882  DT.95267338  DT.100783534  DT.414125  DT.92424044  DT.95267333 
    DT.92053916  DT.121185294  DT.95267339  DT.100719742  DT.100776193  DT.100776200  DT.121185253  DT.121185261 
    DT.40107370  DT.91701327  DT.92424047  DT.97844700  DT.97855871 

    Selected AceView cDNA sequences (see all 336):

    BM714382 Z38631 AI222850 BE466664 BU071294 BF514187 AA620503 T16747 
    AK026880 AI652521 AI198900 AW499886 D26362 BM807235 T33721 BI711375 
    AA761854 BQ182276 F01935 CF139634 AA580528 AW674751 BQ672051 AI345989 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BRD3 expression in normal human tissues (normalized intensities)      BRD3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    BRD3 Expression
    About this image


    BRD3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             Testis Somatic Cells Primitive Gonad
     
     Gonad (Reproductive System)
             Testis Somatic Cells Primitive Gonad
    BRD3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BRD3 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.522472 Hs.654869

    UniProtKB/Swiss-Prot: BRD3_HUMAN, Q15059
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Array including BRD3: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for BRD3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BRD3
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    QuantiFast Probe-based Assays in human, mouse, rat BRD3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRD3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BRD3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Brd31 , 5 bromodomain containing 31, 5 87.81(n)1
    95(a)1
      2 (19.38 cM)5
    673821  NM_023336.41  NP_075825.31 
     274455795 
    chicken
    (Gallus gallus)
    Aves BRD31 bromodomain containing 3 81.17(n)
    92.33(a)
      427757  XM_425330.4  XP_425330.2 
    lizard
    (Anolis carolinensis)
    Reptilia BRD36
    bromodomain containing 3
    85(a)
    1 ↔ 1
    GL343736.1(32014-70163)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL965484.22   -- 79.03(n)    AL965484.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc56a112 Danio rerio cDNA clone IMAGE5604925, partial cds 79.51(n)    BC055533.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fs(1)h3 regulation of transcription from Pol II
    promoter more
    56(a)     --


    ENSEMBL Gene Tree for BRD3 (if available)
    TreeFam Gene Tree for BRD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BRD3 gene
    BRDT2  BRD42  CREBBP2  BRD22  EP3002  
    5 SIMAP similar genes for BRD3 using alignment to 4 protein entries:     BRD3_HUMAN (see all proteins):
    BRDT    BRD2    BRD4    DKFZp686N0336    DKFZp313H139

    BRD3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BRD3 (see all 1023)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0419134
    A renal clear cell carcinoma sample4--see VAR_0419132 T N mis40--------
    VAR_0419144
    A gastric adenocarcinoma sample4--see VAR_0419142 A T mis40--------
    rs1143670191,2
    C,F--136897221(+) TGGCCG/AGAGCC 1 -- ut311Minor allele frequency- A:0.10WA 118
    rs354117201,2
    C--136897458(+) CAGTCTT/-TTAAA 1 -- ut311Minor allele frequency- -:0.50NA 2
    rs1125750011,2
    F--136897535(+) TGTCTA/GTACCT 1 -- ut312Minor allele frequency- G:0.02CSA WA 120
    rs798896731,2
    C--136897584(+) AAAACA/CACAAA 1 -- ut310--------
    rs4438651,2
    C--136897598(+) AAAAAC/ACAAAA 1 -- ut311Minor allele frequency- A:0.50NA 2
    rs1486568921,2
    --136897694(+) CCGCCA/GCCAGA 1 -- ut310--------
    rs109938961,2
    C,F,A,H--136897709(+) ACCCGC/G/TGCCCG 2 -- ut31 ese39EA NS NA WA CSA 531
    rs2002925981,2
    --136897976(+) TTTTT-/TTAAATCT 1 -- cds10--------

    HapMap Linkage Disequilibrium report for BRD3 (136895427 - 136933657 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for BRD3 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2739138CNV Deletion23290073
    dgv8343n71CNV Loss21882294
    dgv8341n71CNV Loss21882294
    nsv894132CNV Loss21882294
    nsv831749CNV Loss17160897
    dgv8339n71CNV Loss21882294
    nsv428226CNV Loss18775914
    nsv894152CNV Loss21882294
    nsv466629CNV Loss19166990
    nsv831748CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601541    OMIM disorders: --

    UniProtKB/Swiss-Prot: BRD3_HUMAN, Q15059
  • Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising
    in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion
    protein

  • 6 diseases for BRD3:    About MalaCards
    nasopharyngitis    hiv-1    endotheliitis    multiple myeloma
    myeloma    malaria


    BRD3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): BRD3

    Export disorders for BRD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BRD3 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with BRD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)1, 2, 3 Nomura N.... Tabata S. (DNA Res. 1994)
    2. Chromosomal localization, gene structure and transcription pattern of the ORFX gene, a homologue of the MHC-linked RING3 gene. (PubMed id 9373153)1, 2, 9 Thorpe K.L.... Beck S. (Gene 1997)
    3. New gene functions in megakaryopoiesis and platelet formation. (PubMed id 22139419)1, 4 Gieger C....Soranzo N. (Nature 2011)
    4. The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription. (PubMed id 18406326)1, 2 LeRoy G.... Flint S.J. (Mol. Cell 2008)
    5. BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells. (PubMed id 17934517)1, 2 French C.A.... Aster J.C. (Oncogene 2008)
    6. Differentially expressed genes in endothelial differentiation. (PubMed id 16008511)1, 2 Ishii H.... Vecchione A. (DNA Cell Biol. 2005)
    7. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Phylogeny and structure of the RING3 gene. (PubMed id 8781126)1, 3 Thorpe K.L.... Beck S. (Immunogenetics 1996)
    10. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8019 HGNC: 1104 AceView: BRD3 Ensembl:ENSG00000169925 euGenes: HUgn8019
    ECgene: BRD3 H-InvDB: BRD3

    (According to HUGE)
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    HUGE: KIAA0043

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BRD3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BRD3 gene:
    Search GeneIP for patents involving BRD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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