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Aliases for BRD3 Gene

Aliases for BRD3 Gene

  • Bromodomain Containing 3 2 3 5
  • Bromodomain-Containing 3 2 3
  • RING3-Like Protein 3 4
  • RING3L 3 4
  • Bromodomain-Containing Protein 3 Short Isoform 3
  • RING3-Like 2
  • KIAA0043 4
  • ORFX 3

External Ids for BRD3 Gene

Previous GeneCards Identifiers for BRD3 Gene

  • GC09M127972
  • GC09M128566
  • GC09M130323
  • GC09M132239
  • GC09M133927
  • GC09M135886
  • GC09M136897
  • GC09M106393

Summaries for BRD3 Gene

Entrez Gene Summary for BRD3 Gene

  • This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for BRD3 Gene

BRD3 (Bromodomain Containing 3) is a Protein Coding gene. Diseases associated with BRD3 include infant botulism and foodborne botulism. GO annotations related to this gene include chromatin binding and lysine-acetylated histone binding. An important paralog of this gene is BRD4.

UniProtKB/Swiss-Prot for BRD3 Gene

  • Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene.

Tocris Summary for BRD3 Gene

Gene Wiki entry for BRD3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRD3 Gene

Genomics for BRD3 Gene

Regulatory Elements for BRD3 Gene

Promoters for BRD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BRD3 on UCSC Golden Path with GeneCards custom track

Genomic Location for BRD3 Gene

Chromosome:
9
Start:
134,030,305 bp from pter
End:
134,068,535 bp from pter
Size:
38,231 bases
Orientation:
Minus strand

Genomic View for BRD3 Gene

Genes around BRD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRD3 Gene

Proteins for BRD3 Gene

  • Protein details for BRD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15059-BRD3_HUMAN
    Recommended name:
    Bromodomain-containing protein 3
    Protein Accession:
    Q15059
    Secondary Accessions:
    • B1APD9
    • Q4G5Y3
    • Q5T1R7
    • Q8N5M3
    • Q92645

    Protein attributes for BRD3 Gene

    Size:
    726 amino acids
    Molecular mass:
    79542 Da
    Quaternary structure:
    • Interacts (via bromo domain 1) with GATA1 acetylated at Lys-312 and Lys-315. Interacts (via bromo domain 1) with GATA2 acetylated on lysine residues (By similarity). Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (in vitro).
    SequenceCaution:
    • Sequence=BAA05393.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BRD3 Gene

    Alternative splice isoforms for BRD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BRD3 Gene

Proteomics data for BRD3 Gene at MOPED

Post-translational modifications for BRD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BRD3 Gene

Antibody Products

No data available for DME Specific Peptides for BRD3 Gene

Domains & Families for BRD3 Gene

Protein Domains for BRD3 Gene

Suggested Antigen Peptide Sequences for BRD3 Gene

Graphical View of Domain Structure for InterPro Entry

Q15059

UniProtKB/Swiss-Prot:

BRD3_HUMAN :
  • Contains 2 bromo domains.
Domain:
  • Contains 2 bromo domains.
  • Contains 1 NET domain.
genes like me logo Genes that share domains with BRD3: view

No data available for Gene Families for BRD3 Gene

Function for BRD3 Gene

Molecular function for BRD3 Gene

UniProtKB/Swiss-Prot Function:
Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene.

Gene Ontology (GO) - Molecular Function for BRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 20195357
genes like me logo Genes that share ontologies with BRD3: view
genes like me logo Genes that share phenotypes with BRD3: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BRD3 Gene

Localization for BRD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRD3 Gene

Nucleus. Note=Detected on chromatin. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BRD3 Gene COMPARTMENTS Subcellular localization image for BRD3 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for BRD3 Gene

Pathways & Interactions for BRD3 Gene

SuperPathways for BRD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BRD3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for BRD3 Gene

Drugs & Compounds for BRD3 Gene

(17) Drugs for BRD3 Gene - From: ApexBio, DGIdb, and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
I-BET-762 Pharma BET inhibitor,highly potent 0
Pharmaceutical Solutions Pharma 7004
CPI-203 Pharma BET bromodomain inhibitor 0
I-BET151 (GSK1210151A) Pharma Selective BET inhibitor 0
MS436 Pharma BRD4 inhibitor 0
genes like me logo Genes that share compounds with BRD3: view

Transcripts for BRD3 Gene

Unigene Clusters for BRD3 Gene

Bromodomain containing 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BRD3 Gene

No ASD Table

Relevant External Links for BRD3 Gene

GeneLoc Exon Structure for
BRD3
ECgene alternative splicing isoforms for
BRD3

Expression for BRD3 Gene

mRNA expression in normal human tissues for BRD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BRD3 Gene

This gene is overexpressed in Vitreous humor (15.1), Synovial fluid (10.8), and Lymph node (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BRD3 Gene



SOURCE GeneReport for Unigene cluster for BRD3 Gene Hs.522472

mRNA Expression by UniProt/SwissProt for BRD3 Gene

Q15059-BRD3_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with BRD3: view

Protein tissue co-expression partners for BRD3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for BRD3 Gene

Orthologs for BRD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for BRD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BRD3 36
  • 100 (a)
OneToOne
BRD3 35
  • 99.36 (n)
  • 99.72 (a)
cow
(Bos Taurus)
Mammalia BRD3 36
  • 94 (a)
OneToOne
BRD3 35
  • 88.68 (n)
  • 93.32 (a)
dog
(Canis familiaris)
Mammalia BRD3 35
  • 89.93 (n)
  • 94.68 (a)
BRD3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Brd3 16
Brd3 35
  • 87.81 (n)
  • 95 (a)
Brd3 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BRD3 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BRD3 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Brd3 35
  • 88.02 (n)
  • 95.29 (a)
chicken
(Gallus gallus)
Aves BRD3 35
  • 81.17 (n)
  • 92.33 (a)
BRD3 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BRD3 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia brd3 35
  • 74.65 (n)
  • 83.45 (a)
zebrafish
(Danio rerio)
Actinopterygii brd3a 36
  • 75 (a)
OneToOne
brd3a 35
  • 69.21 (n)
  • 76.82 (a)
wufc56a11 35
fruit fly
(Drosophila melanogaster)
Insecta fs(1)h 37
  • 56 (a)
fs(1)h 36
  • 18 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2782 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToMany
Species with no ortholog for BRD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRD3 Gene

ENSEMBL:
Gene Tree for BRD3 (if available)
TreeFam:
Gene Tree for BRD3 (if available)

Paralogs for BRD3 Gene

Paralogs for BRD3 Gene

(5) SIMAP similar genes for BRD3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with BRD3: view

Variants for BRD3 Gene

Sequence variations from dbSNP and Humsavar for BRD3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs378569 -- 134,037,293(+) AGggc(C/T)gggcg intron-variant
rs392134 -- 134,043,886(-) TGAGA(C/T)GAGCT intron-variant
rs416390 -- 134,043,427(-) TCTGA(C/G)CTTGG intron-variant
rs437182 -- 134,042,598(+) tgcca(C/T)tgcac intron-variant
rs457420 -- 134,044,139(-) ACCTC(A/G)CTTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BRD3 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV Deletion 23290073
nsv894125 CNV Loss 21882294
dgv8337n71 CNV Loss 21882294
nsv831748 CNV Loss 17160897
nsv831749 CNV Loss 17160897
nsv894132 CNV Loss 21882294
nsv428226 CNV Loss 18775914
dgv8339n71 CNV Loss 21882294
nsv825148 CNV Gain 20364138
dgv8341n71 CNV Loss 21882294
dgv8342n71 CNV Loss 21882294
dgv8343n71 CNV Loss 21882294
nsv466627 CNV Loss 19166990
nsv894150 CNV Loss 21882294
nsv466629 CNV Loss 19166990
nsv825149 CNV Gain 20364138
nsv894152 CNV Loss 21882294
esv25492 CNV Loss 19812545

Variation tolerance for BRD3 Gene

Residual Variation Intolerance Score: 6.84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.79; 47.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BRD3 Gene

HapMap Linkage Disequilibrium report
BRD3
Human Gene Mutation Database (HGMD)
BRD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRD3 Gene

Disorders for BRD3 Gene

MalaCards: The human disease database

(7) MalaCards diseases for BRD3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
infant botulism
  • infant intestinal botulism
foodborne botulism
  • intoxication botulism
in situ pulmonary adenocarcinoma
  • bronchioalveolar carcinoma
nut midline carcinoma
  • nuclear protein in testis midline carcinoma
botulism
  • botulism poisoning
- elite association - COSMIC cancer census association via MalaCards
Search BRD3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

BRD3_HUMAN
  • Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein.

Relevant External Links for BRD3

Genetic Association Database (GAD)
BRD3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BRD3
genes like me logo Genes that share disorders with BRD3: view

No data available for Genatlas for BRD3 Gene

Publications for BRD3 Gene

  1. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7584044) Nomura N. … Tabata S. (DNA Res. 1994) 2 3 4 67
  2. Chromosomal localization, gene structure and transcription pattern of the ORFX gene, a homologue of the MHC-linked RING3 gene. (PMID: 9373153) Thorpe K.L. … Beck S. (Gene 1997) 3 23
  3. Phylogeny and structure of the RING3 gene. (PMID: 8781126) Thorpe K.L. … Beck S. (Immunogenetics 1996) 2 3
  4. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for BRD3 Gene

Sources for BRD3 Gene

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