Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BRD3 Gene

protein-coding   GIFtS: 56
GCID: GC09M136897

bromodomain containing 3

(Previous name: bromodomain-containing 3 )
 Explore 2 diseases affiliated with
BRD3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for BRD3    

Aliases
for BRD3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Bromodomain Containing 31 2     KIAA00431 3
RING3L1 2 3 5     RING3-Like Protein2 3
ORFX1 2 5     Bromodomain-Containing Protein 32
Bromodomain-Containing 31 2     

External Ids:    HGNC: 11041   Entrez Gene: 80192   Ensembl: ENSG000001699257   OMIM: 6015415   UniProtKB: Q150593   

Export aliases for BRD3 gene to outside databases

Previous GC identifers: GC09M127972 GC09M128566 GC09M130323 GC09M132239 GC09M133927 GC09M135886 GC09M106393


Summaries
for BRD3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for BRD3:
This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The
gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of
the encoded protein is not known. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: BRD3_HUMAN, Q15059
Function: Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin
remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the
transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene

Gene Wiki entry for BRD3


Genomic Views
for BRD3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_035014.4  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BRD3 gene promoter:
         AhR   Pax-5   AML1a   RelA   Cdc5   Evi-1   Max   c-Myb   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: BRD3 promoter sequence
   Search SABiosciences Chromatin IP Primers for BRD3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BRD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34   Ensembl cytogenetic band:  9q34.2   HGNC cytogenetic band: 9q34

BRD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRD3 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M136897:  view genomic region     (about GC identifiers)

Start:
 136,894,789 bp from pter      End:
 136,933,657 bp from pter
Size:
 38,869 bases      Orientation:
 minus strand

Proteins
for BRD3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: BRD3_HUMAN, Q15059 (See protein sequence)
Recommended Name: Bromodomain-containing protein 3  
Size: 726 amino acids; 79542 Da
Subunit: Interacts (via bromo domain 1) with GATA1 acetylated at 'Lys-312' and 'Lys-315'. Interacts (via bromo domain
1) with GATA2 acetylated on lysine residues (By similarity). Interacts (via bromo domains) with acetylated lysine
residues on the N-terminus of histone H2A, H2B, H3 and H4 (in vitro)
Subcellular location: Nucleus (Probable). Note=Detected on chromatin (By similarity)
Sequence caution: Sequence=BAA05393.2; Type=Erroneous initiation;
6 PDB 3D structures from and Proteopedia for BRD3:
2E7N (3D)        2NXB (3D)        2OO1 (3D)        2YW5 (3D)        3S91 (3D)        3S92 (3D)    
Secondary accessions: B1APD9 Q4G5Y3 Q5T1R7 Q8N5M3 Q92645
Alternative splicing: 2 isoforms:  Q15059-1   Q15059-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BRD3: NX_Q15059

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15059

    • BRD3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_031397.1  
    ENSEMBL proteins: 
     ENSP00000305918   ENSP00000360900   ENSP00000360908   ENSP00000406749   ENSP00000350557  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: BRD3
    OriGene Custom Protein Services for BRD3 
    GenScript Custom Purified and Recombinant Proteins Services for BRD3
    Novus Biologicals BRD3 Proteins
    Novus Biologicals BRD3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for BRD3

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--


    BRD3 for ontologies           About GeneDecksing



    BRD3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for BRD3 
    GenScript Custom Superior Antibodies Services for BRD3
    Novus Biologicals BRD3 Antibodies
    Abcam antibodies for BRD3 
    Uscn Antibodies for BRD3
    ThermoFisher Antibodies for BRD3

    Assay Products for BRD3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BRD3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for BRD3

    Protein Domains /
    Families
    for BRD3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    BRD3 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR018359 Bromodomain_CS
     IPR001487 Bromodomain

    Graphical View of Domain Structure for InterPro Entry Q15059

    ProtoNet protein and cluster: Q15059

    1 Blocks protein family: IPB001487 Bromodomain signature

    UniProtKB/Swiss-Prot: BRD3_HUMAN, Q15059
    Similarity: Contains 2 bromo domains
    Similarity: Contains 1 NET domain


    Function
    for BRD3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: BRD3_HUMAN, Q15059
    Function: Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin
    remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the
    transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene

    miRNA
    Products:            		miRTarBase miRNAs that target BRD3:
    hsa-mir-192 (MIRT004162), hsa-mir-141 (MIRT003279)

    OriGene 3'-UTR Clone: BRD3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BRD3
    8/94 QIAGEN miScript miRNA Assays for microRNAs that regulate BRD3 (see all 94):
    hsa-miR-548j hsa-miR-582-3p hsa-miR-485-3p hsa-miR-200a hsa-miR-3653 hsa-miR-10b* hsa-miR-1304 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmid: BRD3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BRD3 (see all 7)
    OriGene shRNA RFP: BRD3
    OriGene siRNA: BRD3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BRD3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for BRD3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BRD3 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BRD3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: BRD3 (NM_007371)
    Sino Biological Human cDNA Clone for BRD3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BRD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRD3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for BRD3
    Search LifeMap BioReagents cell lines for BRD3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRD3

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003682chromatin binding IDA18406326
    GO:0005515protein binding IPI--
    GO:0070577histone acetyl-lysine binding IDA--


    BRD3 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for BRD3:
     Decreased substrate adherent c  Increased cell death HMECs cel 

    Animal Models:
         1 MGI phenotypic allele for Brd3 (no phenotypes)

    BRD3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for BRD3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BRD3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/6 Interacting proteins for BRD3 (Q150591, 2, 3 ENSP000003059184) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP1LC3BQ9GZQ82, 3MINT-8259492 I2D: score=2 
    MYCP011061, 3EBI-1383460,EBI-1058440 I2D: score=1 
    BRD7Q9NPI13, ENSP000003781804I2D: score=1 STRING: ENSP00000378180
    JUNP054123I2D: score=2 
    BRD4ENSP000002633774STRING: ENSP00000263377
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter IDA18406326
    GO:0008150biological_process ND--
    GO:0016568chromatin modification IEA--


    BRD3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for BRD3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BRD3
    Search CenterWatch for drugs/clinical trials and news about BRD3 

    Transcripts
    for BRD3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for BRD3 gene: 
    NM_007371.3  

    Unigene Clusters for BRD3:

    Bromodomain containing 3
    Hs.522472  [show with all ESTs], Hs.654869  [show with all ESTs]
    Unigene Representative Sequences: NM_007371, NR_015427
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000303407(uc004cew.3) ENST00000473349 ENST00000371834(uc004cex.2)
    ENST00000494743 ENST00000371842 ENST00000433041 ENST00000357885

    miRNA
    Products:             		 OriGene 3'-UTR Clone: BRD3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BRD3
    8/94 QIAGEN miScript miRNA Assays for microRNAs that regulate BRD3 (see all 94):
    hsa-miR-548j hsa-miR-582-3p hsa-miR-485-3p hsa-miR-200a hsa-miR-3653 hsa-miR-10b* hsa-miR-1304 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmid: BRD3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BRD3 (see all 7)
    OriGene shRNA RFP: BRD3
    OriGene siRNA: BRD3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BRD3
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BRD3 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BRD3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: BRD3 (NM_007371)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BRD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRD3 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BRD3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BRD3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BRD3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BRD3

    Additional cDNA sequence: 

    AK092667.1 AK123322.1 AY203934.1 BC053543.1 BC065204.1 BC094875.1 BC108326.1 NR_015427.2 

    21 DOTS entries:

    DT.414124  DT.445025  DT.446882  DT.95267338  DT.100783534  DT.414125  DT.92424044  DT.95267333 
    DT.92053916  DT.121185294  DT.95267339  DT.100719742  DT.100776193  DT.100776200  DT.121185253  DT.121185261 
    DT.40107370  DT.91701327  DT.92424047  DT.97844700  DT.97855871 

    24/336 AceView cDNA sequences (see all 336):

    AA128903 T33721 N34842 AK026880 BU949410 BF061923 N43917 AI345989 
    CR592591 AW675355 BM875495 T16450 AI222850 BE466664 Z38631 CA429148 
    CR625329 AA580528 BF001897 BQ640105 BM910839 CF139634 AW518696 AW499886 

    GeneLoc Exon Structure


    Expression
    for BRD3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BRD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    BRD3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Reproductive SystemEarly GonadTestis Somatic CellsTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See BRD3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BRD3

    SOURCE GeneReport for Unigene clusters: Hs.522472 Hs.654869

    UniProtKB/Swiss-Prot: BRD3_HUMAN, Q15059
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Array including BRD3: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BRD3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BRD3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BRD3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BRD3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRD3

    Orthologs
    for BRD3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for BRD3 gene from 9/30 species (see all 30)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves BRD31 bromodomain containing 3 81.3(n)
    91.97(a)    		   427757  XM_425330.3  XP_425330.2 
    lizard
    (Anolis carolinensis)    		 Reptilia BRD36
    		 --
    		 85(a)
    		 1 ↔ 1
    		 GL343736.1(42762-70163)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia AL965484.22   -- 79.03(n)    AL965484.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufc56a112 Danio rerio cDNA clone IMAGE5604925, partial cds 79.51(n)    BC055533.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta fs(1)h1 , 3 regulation of transcription from Pol II
    promoter more3
    female sterile (1) homeotic1    		 56(a)3
    57.22(n)1
    54.79(a)1    		   317221  NM_078523.21  NP_511078.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea bet-11 Protein BET-1 44.44(n)
    34.94(a)    		   172054  NM_058983.2  NP_491384.2 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes BDF11 Bdf1p 44.03(n)
    33.58(a)    		   851115   NP_013503.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons NPX16
    GTE36
    (see all 12)    		 bromodomain-containing protein GTE3
    (see all 12)    		 8(a)
    23(a)
    (see all 12)    		 possible ortholog
    many ↔ many
    (see all 12)    		 5(25374413-25379297)
    1(27504112-27506112)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 11)    		 bromodomain domain containing protein, expressed
    (see all 11)    		 5(a)
    32(a)
    (see all 11)    		 possible ortholog
    possible ortholog
    (see all 11)    		 8(1566556-1572065)
    1(26172141-26176186)


    ENSEMBL Gene Tree for BRD3 (if available)
    TreeFam Gene Tree for BRD3 (if available) 

    Paralogs
    for BRD3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BRD3 gene
    BRDT2  BRD42  CREBBP2  BRD22  EP3002  
    5 SIMAP similar genes for BRD3 using alignment to 4 protein entries:     BRD3_HUMAN (see all proteins):
    BRDT    BRD2    DKFZp686N0336    DKFZp313H139    BRD4

    BRD3 for paralogs           About GeneDecksing



    Genomic Variants
    for BRD3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1092 NCBI SNPs in BRD3 are shown (see all 1092)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1399803301,2
    		C,--106415122(+) GGCCCA/GCATCT 1 -- us2k10--------
    rs617316421,2
    		C,F,--106415188(+) CATTCG/ACTTGC 1 -- us2k12Minor allele frequency- A:0.00NS NA 4608
    rs766763141,2
    		C,--106415280(+) GGAAAA/GAGATT 1 -- us2k10--------
    rs776778161,2
    		--106415553(+) CAAACC/TTTCCA 1 -- us2k10--------
    rs177370811,2
    		C,F,--106415731(+) CACTCG/AGCCTC 1 -- us2k15Minor allele frequency- A:0.04NA CSA 252
    rs735605241,2
    		C,--106416006(+) CAGAGG/ACAGTC 1 -- us2k12Minor allele frequency- A:0.04WA 120
    rs715052681,2
    		C,F,--106416056(+) CAGCAG/ACAGAA 1 -- us2k13Minor allele frequency- A:0.05NA WA 122
    rs2021347671,2
    		C,--106416089(+) GCTACA/GCACCG 1 -- us2k10--------
    rs771180951,2
    		C,--106416100(+) GCAGGG/TTCAAT 1 -- us2k10--------
    rs1407461591,2
    		C,F--106416108(+) AATTTG/TATTGC 1 -- us2k12Minor allele frequency- T:0.00NA EU 5873

    HapMap Linkage Disequilibrium report for BRD3 (136894789 - 136933657 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for BRD3
         1 CNV: 65546

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BRD3
    DNA2.0 Custom Variant and Variant Library Synthesis for BRD3

    Disorders / Diseases
    for BRD3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    BRD3 for disorders           About GeneDecksing

    OMIM gene information: 601541    OMIM disorders: --

    UniProtKB/Swiss-Prot: BRD3_HUMAN, Q15059
  • Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in
    • midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein

    2 diseases for BRD3:    About MalaCards
    nasopharyngitis    carcinoma


    Export disorders for BRD3 gene to outside databases

    Publications
    for BRD3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BRD3 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with BRD3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)1, 2, 3 Nomura N....Tabata S. (1994)
    2. Chromosomal localization, gene structure and transcription pattern of the ORFX gene, a homologue of the MHC-linked RING3 gene. (PubMed id 9373153)1, 2, 9 Thorpe K.L.... Beck S. (1997)
    3. The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription. (PubMed id 18406326)1, 2 LeRoy G....Flint S.J. (2008)
    4. BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells. (PubMed id 17934517)1, 2 French C.A.... Aster J.C. (2008)
    5. Differentially expressed genes in endothelial differentiation. (PubMed id 16008511)1, 2 Ishii H.... Vecchione A. (2005)
    6. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Phylogeny and structure of the RING3 gene. (PubMed id 8781126)1, 3 Thorpe K.L....Beck S. (1996)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Histone recognition and large-scale structural analysis of the human bromodomain family. (PubMed id 22464331)2 Filippakopoulos P.... Knapp S. (2012)

    External Searches for BRD3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing BRD3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8019 HGNC: 1104 AceView: BRD3 Ensembl:ENSG00000169925 euGenes: HUgn8019
    ECgene: BRD3 H-InvDB: BRD3

    Other Databases showing BRD3 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0043

    Specialized Databases showing BRD3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BRD3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for BRD3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for BRD3 gene:
    Search GeneIP for patents involving BRD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for BRD3 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for BRD3  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BRD3   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BRD3  
     OriGene Protein Over-expression Lysate for BRD3   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for BRD3   OriGene 3'-UTR Clone for BRD3  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BRD3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BRD3  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for BRD3   OriGene Custom Protein Services for BRD3  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BRD3
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BRD3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BRD3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BRD3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BRD3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BRD3
     GenScript Custom Purified and Recombinant Proteins Services for BRD3 GenScript cDNA clones with any tag delivered in your preferred vector for BRD3
     GenScript Custom Assay Services for BRD3 GenScript Custom Superior Antibodies Services for BRD3
     GenScript Custom overexpressing Cell Line Services for BRD3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in BRD3 promoter
     Search Chromatin IP Primers for BRD3
     RT2 qPCR Primer Assay in human, mouse, rat BRD3
     GNC Network for BRD3
     SABiosciences PCR Arrays including human, mouse, rat BRD3
     Search Tocris compounds for BRD3
     Browse Sino Biological Proteins and Antibodies
     cDNA Clones for BRD3
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     BRD3 antibodies
     BRD3 proteins
     BRD3 lysates
     Antibodies for BRD3
     See all of Abcam's Antibodies, Kits and Proteins for BRD3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     BRD3 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for BRD3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRD3
     SwitchGear 3'UTR luciferase reporter plasmids for BRD3
     SwitchGear Promoter luciferase reporter plasmids for BRD3
     ThermoFisher Antibodies for BRD3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRD3
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      BRD3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4