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Aliases for BRD3 Gene

Aliases for BRD3 Gene

  • Bromodomain Containing 3 2 3 5
  • RING3-Like Protein 3 4
  • RING3L 3 4
  • Bromodomain-Containing Protein 3 Short Isoform 3
  • Bromodomain-Containing Protein 3 3
  • Bromodomain-Containing 3 2
  • RING3-Like 2
  • KIAA0043 4
  • ORFX 3

External Ids for BRD3 Gene

Previous GeneCards Identifiers for BRD3 Gene

  • GC09M127972
  • GC09M128566
  • GC09M130323
  • GC09M132239
  • GC09M133927
  • GC09M135886
  • GC09M136897
  • GC09M106393

Summaries for BRD3 Gene

Entrez Gene Summary for BRD3 Gene

  • This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for BRD3 Gene

BRD3 (Bromodomain Containing 3) is a Protein Coding gene. Diseases associated with BRD3 include Foodborne Botulism and Infant Botulism. GO annotations related to this gene include chromatin binding and lysine-acetylated histone binding. An important paralog of this gene is BRD2.

UniProtKB/Swiss-Prot for BRD3 Gene

  • Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene.

Tocris Summary for BRD3 Gene

  • Bromodomains (BRDs) are epigenetic reader domains that selectively recognize acetylated lysine residues on the tails of histone proteins, and are the only known protein modules that can target acetylated lysine residues.

Gene Wiki entry for BRD3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRD3 Gene

Genomics for BRD3 Gene

Regulatory Elements for BRD3 Gene

Enhancers for BRD3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F134065 0.5 ENCODE 11.4 +1.3 1339 4.4 HDGF ATF1 PKNOX1 WRNIP1 ARID4B SIN3A YY1 GLIS2 ELK1 GATA2 WDR5 BRD3 ENSG00000273249 SURF4 LINC00094 LOC100130548
GH09F134054 1.2 Ensembl ENCODE 10.8 +9.3 9344 9.0 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 BRD3 LINC00094 DBH-AS1 LOC100130548
GH09F133953 1.3 FANTOM5 Ensembl ENCODE 6.5 +110.6 110581 8.5 HDGF TBP PKNOX1 WRNIP1 ZFP64 RAD21 GLIS2 EGR1 SCRT2 CREM VAV2 SARDH BRD3 ADAMTSL2 GC09P133952 GC09P133983
GH09F134099 0.4 ENCODE 5.8 -30.8 -30799 0.2 HDAC1 PKNOX1 CREB3L1 ARID4B KLF17 RAD21 RFX5 GLIS2 ZNF143 KLF7 BRD3 ARF4P1 WDR5
GH09F133949 1.1 Ensembl ENCODE 5.5 +117.8 117833 1.7 SMARCA4 POLR2A ZNF341 KLF9 NR2F2 BRD3 GC09P133952 GC09M133930
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around BRD3 on UCSC Golden Path with GeneCards custom track

Promoters for BRD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001316914 935 3600 HDGF PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 YY1 GLIS2 ELK1 GATA2

Genomic Location for BRD3 Gene

Chromosome:
9
Start:
134,030,305 bp from pter
End:
134,068,535 bp from pter
Size:
38,231 bases
Orientation:
Minus strand

Genomic View for BRD3 Gene

Genes around BRD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRD3 Gene

Proteins for BRD3 Gene

  • Protein details for BRD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15059-BRD3_HUMAN
    Recommended name:
    Bromodomain-containing protein 3
    Protein Accession:
    Q15059
    Secondary Accessions:
    • B1APD9
    • Q4G5Y3
    • Q5T1R7
    • Q8N5M3
    • Q92645

    Protein attributes for BRD3 Gene

    Size:
    726 amino acids
    Molecular mass:
    79542 Da
    Quaternary structure:
    • Interacts (via bromo domain 1) with GATA1 acetylated at Lys-312 and Lys-315. Interacts (via bromo domain 1) with GATA2 acetylated on lysine residues (By similarity). Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (in vitro).
    SequenceCaution:
    • Sequence=BAA05393.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BRD3 Gene

    Alternative splice isoforms for BRD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BRD3 Gene

Post-translational modifications for BRD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BRD3 Gene

Domains & Families for BRD3 Gene

Protein Domains for BRD3 Gene

Suggested Antigen Peptide Sequences for BRD3 Gene

Graphical View of Domain Structure for InterPro Entry

Q15059

UniProtKB/Swiss-Prot:

BRD3_HUMAN :
  • Contains 2 bromo domains.
Domain:
  • Contains 2 bromo domains.
  • Contains 1 NET domain.
genes like me logo Genes that share domains with BRD3: view

No data available for Gene Families for BRD3 Gene

Function for BRD3 Gene

Molecular function for BRD3 Gene

UniProtKB/Swiss-Prot Function:
Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene.

Gene Ontology (GO) - Molecular Function for BRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 18406326
GO:0005515 protein binding IPI 20195357
GO:0070577 lysine-acetylated histone binding IDA 22464331
genes like me logo Genes that share ontologies with BRD3: view
genes like me logo Genes that share phenotypes with BRD3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for BRD3

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for BRD3

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BRD3 Gene

Localization for BRD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRD3 Gene

Nucleus. Note=Detected on chromatin. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BRD3 Gene COMPARTMENTS Subcellular localization image for BRD3 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for BRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with BRD3: view

Pathways & Interactions for BRD3 Gene

SuperPathways for BRD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for BRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IDA 18406326
GO:0016569 covalent chromatin modification IEA --
genes like me logo Genes that share ontologies with BRD3: view

No data available for Pathways by source and SIGNOR curated interactions for BRD3 Gene

Drugs & Compounds for BRD3 Gene

(26) Drugs for BRD3 Gene - From: ClinicalTrials, ApexBio, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
GW841819X Pharma BET bromodomain inhibitor 0
I-BET-762 Pharma BET inhibitor,highly potent 0
Pharmaceutical Solutions Pharma 7793
BAZ2-ICR Pharma 0
BET-BAY 002 Pharma 0

(20) ApexBio Compounds for BRD3 Gene

Compound Action Cas Number
BAZ2-ICR
BET-BAY 002 1588521-78-1
Bromosporine Bromodomain inhibitor,non-selective 1619994-69-2
CPI-203 BET bromodomain inhibitor 1446144-04-2
GSK 525768A inactive stereoisomer of I-BET-762 1260530-25-3
GSK 5959 901245-65-6
GSK1324726A BET proteins inhibitor 1300031-52-0
GW841819X BET bromodomain inhibitor
I-BET 151 hydrochloride
I-BET151 (GSK1210151A) Selective BET inhibitor 1300031-49-5
I-BET-762 BET inhibitor,highly potent 1260907-17-2
Ischemin sodium salt
MS436 BRD4 inhibitor 1395084-25-9
OF-1 BRPF1B and BRPF2 bromodomain inhibitor 919973-83-4
OTX-015 BRD inhibitor 202590-98-5
OXF BD 02 1429129-68-9
PFI-1 (PF-6405761) BET inhibitor 1403764-72-6
RVX-208 Potent BET bromodomain inhibitor 1044870-39-4
UNC1215 Chemical probe for the methyllysine (Kme) 1415800-43-9
UNC669 L3MBTL antagonist,potent and selective 1314241-44-5
genes like me logo Genes that share compounds with BRD3: view

Transcripts for BRD3 Gene

Unigene Clusters for BRD3 Gene

Bromodomain containing 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for BRD3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BRD3 Gene

No ASD Table

Relevant External Links for BRD3 Gene

GeneLoc Exon Structure for
BRD3
ECgene alternative splicing isoforms for
BRD3

Expression for BRD3 Gene

mRNA expression in normal human tissues for BRD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BRD3 Gene

This gene is overexpressed in Vitreous humor (15.1), Synovial fluid (10.8), and Lymph node (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BRD3 Gene



Protein tissue co-expression partners for BRD3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BRD3 Gene:

BRD3

SOURCE GeneReport for Unigene cluster for BRD3 Gene:

Hs.522472

mRNA Expression by UniProt/SwissProt for BRD3 Gene:

Q15059-BRD3_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with BRD3: view

Primer Products

No data available for mRNA differential expression in normal tissues for BRD3 Gene

Orthologs for BRD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for BRD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BRD3 34 35
  • 99.36 (n)
oppossum
(Monodelphis domestica)
Mammalia BRD3 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BRD3 34 35
  • 89.93 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia BRD3 35
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BRD3 34 35
  • 88.68 (n)
rat
(Rattus norvegicus)
Mammalia Brd3 34
  • 88.02 (n)
mouse
(Mus musculus)
Mammalia Brd3 34 16 35
  • 87.81 (n)
chicken
(Gallus gallus)
Aves BRD3 34 35
  • 81.17 (n)
lizard
(Anolis carolinensis)
Reptilia BRD3 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia brd3 34
  • 74.65 (n)
zebrafish
(Danio rerio)
Actinopterygii brd3a 34 35
  • 69.21 (n)
wufc56a11 34
fruit fly
(Drosophila melanogaster)
Insecta fs(1)h 36 35
  • 56 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2782 34
Species where no ortholog for BRD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRD3 Gene

ENSEMBL:
Gene Tree for BRD3 (if available)
TreeFam:
Gene Tree for BRD3 (if available)

Paralogs for BRD3 Gene

Paralogs for BRD3 Gene

(5) SIMAP similar genes for BRD3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with BRD3: view

Variants for BRD3 Gene

Sequence variations from dbSNP and Humsavar for BRD3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_041913 A renal clear cell carcinoma sample
VAR_041914 A gastric adenocarcinoma sample
rs10114627 -- 134,044,158(+) AAAAC(C/T)AGGGT intron-variant
rs10118005 -- 134,051,110(+) CTCCC(C/G/T)GACAG intron-variant, upstream-variant-2KB
rs10119081 -- 134,059,455(+) GGCAG(C/T)GGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BRD3 Gene

Variant ID Type Subtype PubMed ID
dgv12966n54 CNV gain 21841781
dgv12967n54 CNV gain 21841781
dgv12968n54 CNV gain+loss 21841781
dgv12969n54 CNV loss 21841781
esv25492 CNV loss 19812545
esv2739138 CNV deletion 23290073
esv3621951 CNV loss 21293372
nsv1075279 CNV deletion 25765185
nsv1125319 OTHER inversion 24896259
nsv1133746 CNV deletion 24896259
nsv428226 CNV loss 18775914
nsv466627 CNV loss 19166990
nsv466629 CNV loss 19166990
nsv615774 CNV loss 21841781
nsv615779 CNV loss 21841781
nsv615780 CNV loss 21841781
nsv615781 CNV gain 21841781
nsv615784 CNV loss 21841781
nsv825148 CNV gain 20364138
nsv825149 CNV gain 20364138
nsv831748 CNV loss 17160897
nsv831749 CNV loss 17160897
nsv951805 CNV deletion 24416366

Variation tolerance for BRD3 Gene

Residual Variation Intolerance Score: 6.84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.79; 47.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BRD3 Gene

Human Gene Mutation Database (HGMD)
BRD3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
BRD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRD3 Gene

Disorders for BRD3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for BRD3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
foodborne botulism
  • wound botulism
infant botulism
  • infant intestinal botulism
in situ pulmonary adenocarcinoma
  • bronchioalveolar carcinoma
nut midline carcinoma
  • nuclear protein in testis midline carcinoma
amyotrophic lateral sclerosis 4, juvenile
  • amyotrophic lateral sclerosis type 4
- elite association - COSMIC cancer census association via MalaCards
Search BRD3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

BRD3_HUMAN
  • Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein.

Relevant External Links for BRD3

Genetic Association Database (GAD)
BRD3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BRD3
genes like me logo Genes that share disorders with BRD3: view

No data available for Genatlas for BRD3 Gene

Publications for BRD3 Gene

  1. Chromosomal localization, gene structure and transcription pattern of the ORFX gene, a homologue of the MHC-linked RING3 gene. (PMID: 9373153) Thorpe K.L. … Beck S. (Gene 1997) 3 4 22 64
  2. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7584044) Nomura N. … Tabata S. (DNA Res. 1994) 2 3 4 64
  3. Histone recognition and large-scale structural analysis of the human bromodomain family. (PMID: 22464331) Filippakopoulos P. … Knapp S. (Cell 2012) 3 4 64
  4. New gene functions in megakaryopoiesis and platelet formation. (PMID: 22139419) Gieger C. … Soranzo N. (Nature 2011) 3 46 64
  5. BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells. (PMID: 17934517) French C.A. … Aster J.C. (Oncogene 2008) 3 4 64

Products for BRD3 Gene

Sources for BRD3 Gene

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