Aliases for BRD2 Gene
External Ids for BRD2 Gene
Previous HGNC Symbols for BRD2 Gene
Previous GeneCards Identifiers for BRD2 Gene
This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010]
GeneCards Summary for BRD2 Gene
BRD2 (Bromodomain Containing 2) is a Protein Coding gene. Diseases associated with BRD2 include Epilepsy, Generalized, With Febrile Seizures Plus, Type 5 and Prolapse Of Female Genital Organ. Among its related pathways are Regulation of retinoblastoma protein and Wnt / Hedgehog / Notch. GO annotations related to this gene include chromatin binding and lysine-acetylated histone binding. An important paralog of this gene is BRD3.
UniProtKB/Swiss-Prot for BRD2 Gene
May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.
Bromodomains (BRDs) are epigenetic reader domains that selectively recognize acetylated lysine residues on the tails of histone proteins, and are the only known protein modules that can target acetylated lysine residues.