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BRD2 Gene

protein-coding   GIFtS: 66
GCID: GC06P032958

Bromodomain Containing 2

(Previous name: bromodomain-containing 2)
  See BRD2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Bromodomain Containing 21 2     FSH2
RING32 3 5     NAT2
Bromodomain-Containing 21 2     RNF32
Really Interesting New Gene 3 Protein2 3     Bromodomain-Containing Protein 22
O27.1.12 3     Female Sterile Homeotic-Related Gene 12
FSRG12 5     KIAA90013
D6S113E2     

External Ids:    HGNC: 11031   Entrez Gene: 60462   Ensembl: ENSG000002042567   OMIM: 6015405   UniProtKB: P254403   
ORGUL members:         

Export aliases for BRD2 gene to outside databases

Previous GC identifers: GC06P032938 GC06P032707 GC06P032983 GC06P033044 GC06P032678 GC06P032944 GC06P032945 GC06P032949


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BRD2 Gene:
This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain)
family of proteins. This protein associates with transcription complexes and with acetylated chromatin during
mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The
gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence
comparison suggests that the protein is not involved in the immune response. This gene has been implicated in
juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple
alternatively spliced variants have been described for this gene. (provided by RefSeq, Dec 2010)

GeneCards Summary for BRD2 Gene:
BRD2 (bromodomain containing 2) is a protein-coding gene. Diseases associated with BRD2 include photosensitive epilepsy. GO annotations related to this gene include histone acetyl-lysine binding and chromatin binding. An important paralog of this gene is BRDT.

UniProtKB/Swiss-Prot: BRD2_HUMAN, P25440
Function: May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin
and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of
the CCND1 gene. Plays a role in nucleosome assembly

summary for BRD2 Gene:
Bromodomains (BRDs) are epigenetic readers that selectively recognize acetylated lysine (Kac) residues on
histone protein tails, and are the only known protein modules that target Kac residues. There are
approximately 62 unique human bromodomains, most of which can be classified according to sequence identity
into nine groups.

Gene Wiki entry for BRD2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NT_113891.3  NT_167246.2  NT_167248.2  NT_167249.2  NC_018917.2  NT_167245.2  
NT_167247.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BRD2 gene promoter:
         TBP   SRY   TFIID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): BRD2 promoter sequence
   Search Chromatin IP Primers for BRD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BRD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

BRD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRD2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P032958:  view genomic region     (about GC identifiers)

Start:
32,936,437 bp from pter      End:
32,949,282 bp from pter
Size:
12,846 bases      Orientation:
plus strand

6 alternative locations:
Chr6+,NT_167249 4,367,205-4,430,060      Chr6+,NT_167247 4,273,302-4,283,842      Chr6+,NT_167245 4,195,782-4,230,624     
Chr6+,NT_167248 4,168,581-4,181,419      Chr6+,NT_113891.2 4,380,975-4,393,826      Chr6+,NT_167246 4,393,664-4,406,503     
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for BRD2

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BRD2_HUMAN, P25440 (See protein sequence)
Recommended Name: Bromodomain-containing protein 2  
Size: 801 amino acids; 88061 Da
Subunit: Homodimer. Interacts with E2F1 and with histone H4 acetylated at 'Lys-13'
Sequence caution: Sequence=AAA68890.1; Type=Erroneous initiation;
Selected PDB 3D structures from and Proteopedia for BRD2 (see all 25):
1X0J (3D)        2DVQ (3D)        2DVR (3D)        2DVS (3D)        2DVV (3D)        2E3K (3D)    
Secondary accessions: A2AAU0 B0S7P0 B1AZT1 O00699 O00700 Q15310 Q5STC9 Q6P3U2 Q969U4
Alternative splicing: 2 isoforms:  P25440-1   P25440-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BRD2: NX_P25440

Explore proteomics data for BRD2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See BRD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001106653.1  NP_001186384.1  NP_001186385.1  NP_005095.1  

    ENSEMBL proteins: 
     ENSP00000363958   ENSP00000464077   ENSP00000411195   ENSP00000363964   ENSP00000436322  
     ENSP00000431514   ENSP00000475691   ENSP00000378702   ENSP00000409613   ENSP00000475288  
     ENSP00000433751   ENSP00000378704   ENSP00000409145   ENSP00000413495  

    BRD2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for BRD2
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    Novus Biologicals BRD2 Proteins
    Novus Biologicals BRD2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BRD2

     
    Search eBioscience for Proteins for BRD2 

    BRD2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of BRD2
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for BRD2 
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    Abcam antibodies for BRD2
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    ThermoFisher Antibodies for BRD2
    LSBio Antibodies in human, mouse, rat for BRD2

    BRD2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BRD2
    Cloud-Clone Corp. CLIAs for BRD2
    Search eBioscience for ELISAs for BRD2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: bromodomain containing 2
    Bromodomain kinase (BRD) family

    3 InterPro protein domains:
     IPR027353 NET_dom
     IPR018359 Bromodomain_CS
     IPR001487 Bromodomain

    Graphical View of Domain Structure for InterPro Entry P25440

    ProtoNet protein and cluster: P25440

    1 Blocks protein domain: IPB001487 Bromodomain signature

    UniProtKB/Swiss-Prot: BRD2_HUMAN, P25440
    Domain: One bromodomain is sufficient for a partial interaction with histone H4 acetylated at 'Lys-13'
    Similarity: Contains 2 bromo domains
    Similarity: Contains 1 NET domain


    Find genes that share domains with BRD2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BRD2_HUMAN, P25440
    Function: May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin
    and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of
    the CCND1 gene. Plays a role in nucleosome assembly

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IDA18406326
    GO:0005515protein binding IPI--
    GO:0070577histone acetyl-lysine binding IDA18406326
         
    Find genes that share ontologies with BRD2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for BRD2:
     Decreased substrate adherent c  Upregulation of Wnt/beta-caten 

         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Brd2):
     adipose tissue  behavior/neurological  cellular  embryogenesis  endocrine/exocrine gland 
     growth/size/body  homeostasis/metabolism  immune system  liver/biliary system  mortality/aging 
     nervous system 

    Find genes that share phenotypes with BRD2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BRD2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BRD2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BRD2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BRD2

    miRNA
    Products:
        
    miRTarBase miRNAs that target BRD2:
    hsa-mir-940 (MIRT036599), hsa-mir-92a-3p (MIRT049226), hsa-mir-877-5p (MIRT037308), hsa-mir-1229-3p (MIRT036359), hsa-mir-505-5p (MIRT037955), hsa-mir-769-3p (MIRT039079), hsa-let-7b-5p (MIRT052027), hsa-mir-504-5p (MIRT041086), hsa-mir-484 (MIRT042162), hsa-let-7c-5p (MIRT051807), hsa-mir-204-5p (MIRT047023), hsa-mir-296-3p (MIRT038361), hsa-mir-615-3p (MIRT039679)

    Block miRNA regulation of human, mouse, rat BRD2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BRD2 (see all 30):
    hsa-miR-3678-3p hsa-miR-495 hsa-miR-185* hsa-miR-3193 hsa-miR-658 hsa-miR-486-3p hsa-miR-373* hsa-miR-3150a-3p
    SwitchGear 3'UTR luciferase reporter plasmidBRD2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BRD2
    Predesigned siRNA for gene silencing in human, mouse, rat BRD2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BRD2

    Clone
    Products:
         
    OriGene clones in human, mouse for BRD2 (see all 12)
    OriGene ORF clones in mouse, rat for BRD2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): BRD2 (NM_005104)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BRD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRD2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for BRD2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRD2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BRD2_HUMAN, P25440: Nucleus (Probable). Note=Detected on chromatin and nucleosomes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with BRD2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BRD2 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    2Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    3Regulation of retinoblastoma protein
    Regulation of retinoblastoma protein
    4Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation


    Find genes that share SuperPaths with BRD2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for BRD2
        Chromatin Regulation / Acetylation
    Wnt / Hedgehog / Notch
    Cell Cycle / Checkpoint Control

    1 BioSystems Pathway for BRD2
        Regulation of retinoblastoma protein


        Pathway & Disease-focused RT2 Profiler PCR Arrays including BRD2: 
              TGFB Signaling Targets in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BRD2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BRD2 (P254401, 2, 3 ENSP000003639584) via UniProtKB, MINT, STRING, and/or I2D (see all 601)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4HP628051, 2, 3, ENSP000002893524EBI-2874802,EBI-302023 MINT-7989539 MINT-7989824 MINT-7989882 MINT-7989846 MINT-7989865 I2D: score=3 STRING: ENSP00000289352
    HIST1H4LP628051, 2, 3, ENSP000003482584EBI-2874802,EBI-302023 MINT-7989539 MINT-7989824 MINT-7989882 MINT-7989846 MINT-7989865 I2D: score=3 STRING: ENSP00000348258
    HIST1H4AP628051, 2, 3EBI-2874802,EBI-302023 MINT-7989539 MINT-7989824 MINT-7989882 MINT-7989846 MINT-7989865 I2D: score=3 
    HIST1H4BP628051, 2, 3EBI-2874802,EBI-302023 MINT-7989539 MINT-7989824 MINT-7989882 MINT-7989846 MINT-7989865 I2D: score=3 
    HIST1H4CP628051, 2, 3EBI-2874802,EBI-302023 MINT-7989539 MINT-7989824 MINT-7989882 MINT-7989846 MINT-7989865 I2D: score=3 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IMP18406326
    GO:0006351transcription, DNA-templated IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter IDA18406326
    GO:0007283spermatogenesis TAS9693039
    GO:0016568chromatin modification IEA--

    Find genes that share ontologies with BRD2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for BRD2 (see all 11)     About this table
    CompoundAction CAS #
    (+)-JQ1BET bromodomain inhibitor[1268524-70-4]
    (-)-JQ1Inactive stereoisomer of bromodomain inhibitor (+)-JQ1[1268524-71-5]
    Bromosporinebroad spectrum inhibitor for bromodomains--
    I-BET-762inhibitor for BET proteins[1260907-17-2]
    I-BET151 (GSK1210151A)BET bromodomain inhibitor(pIC50=6.1,BRD4)[1300031-49-5]
    OTX-015new potent BRD-inhibitor [202590-98-5]
    PFI-1 (PF-6405761)selective BET inhibitor for BRD4[1403764-72-6]
    RVX-208potent BET bromodomain inhibitor for BD2[1044870-39-4]
    SGC-CBP30Potent CREBBP/EP300 bromodomain inhibitor--
    UNC1215elective MBT antagonist[1415800-43-9]

    Compounds for BRD2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PFI 1BET bromodomain inhibitor[1403764-72-6]
    I-BET 151 hydrochlorideBET bromodomain inhibitor[1300031-49-5]
    I-CBP 112Selective CREBBP/EP300 bromodomain inhibitor--
    (+)-JQ1 Potent, selective BET bromodomain inhibitor; cell permeable [1268524-70-4]

    2 Novoseek inferred chemical compound relationships for BRD2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sulfadiazine 58 1 9288889 (1)
    dihydrofolate 44.9 1 10965846 (1)



    Find genes that share compounds with BRD2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BRD2 gene (4 alternative transcripts): 
    NM_001113182.2  NM_001199455.1  NM_001199456.1  NM_005104.3  

    Unigene Cluster for BRD2:

    Bromodomain containing 2
    Hs.75243  [show with all ESTs]
    Unigene Representative Sequence: NM_005104
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000374825(uc003ocn.4) ENST00000496118 ENST00000456339 ENST00000580234
    ENST00000584808 ENST00000374831(uc003oco.3 uc003ocq.4) ENST00000581002
    ENST00000495733(uc010jug.1) ENST00000482914(uc003ocp.4) ENST00000607833
    ENST00000395287 ENST00000449025(uc021ywf.1) ENST00000464592 ENST00000606059
    ENST00000481259 ENST00000463639 ENST00000469132 ENST00000482838
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate BRD2 (see all 30):
    hsa-miR-3678-3p hsa-miR-495 hsa-miR-185* hsa-miR-3193 hsa-miR-658 hsa-miR-486-3p hsa-miR-373* hsa-miR-3150a-3p
    SwitchGear 3'UTR luciferase reporter plasmidBRD2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat BRD2
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): BRD2 (NM_005104)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BRD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRD2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for BRD2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BRD2
      QuantiTect SYBR Green Assays in human, mouse, rat BRD2
      QuantiFast Probe-based Assays in human, mouse, rat BRD2

    Additional mRNA sequence: 

    AK056504.1 AK309797.1 AL832722.1 BC000477.2 BC001885.1 BC007715.2 BC063840.1 BX647233.1 
    BX648109.1 D42040.1 M80613.1 NR_037625.1 X62083.1 

    Selected DOTS entries (see all 49):

    DT.454148  DT.95370594  DT.100059484  DT.100059487  DT.95370733  DT.95084310  DT.95326043  DT.100868168 
    DT.95323729  DT.91740239  DT.86848798  DT.101987490  DT.91769504  DT.91724106  DT.121352652  DT.95370608 
    DT.100858555  DT.100876074  DT.100868170  DT.121352622  DT.121352491  DT.121352550  DT.121352563  DT.91924655 

    Selected AceView cDNA sequences (see all 889):

    BM821855 BE746680 BQ957786 BM563087 BM553809 AW517277 BI333080 BU682499 
    BQ941561 BM824518 CA775098 BQ018124 AI417742 AW297674 R46360 BM783052 
    BX951281 AI342636 AL711066 BC000477 BM836000 BQ278743 BQ222485 BQ070462 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BRD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGAGGGAAG
    BRD2 Expression
    About this image


    BRD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Negative 2 Thymocytes Thymus
    BRD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BRD2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.75243
        Pathway & Disease-focused RT2 Profiler PCR Arrays including BRD2: 
              TGFB Signaling Targets in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for BRD2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Brd21 , 5 bromodomain containing 21, 5 87.72(n)1
    95.59(a)1
      17 (17.98 cM)5
    143121  NM_010238.31  NP_034368.21 
     341120235 
    chicken
    (Gallus gallus)
    Aves BRD21 bromodomain containing 2 71.54(n)
    80.92(a)
      417049  NM_001030674.1  NP_001025845.1 
    lizard
    (Anolis carolinensis)
    Reptilia BRD26
    bromodomain containing 2
    76(a)
    1 ↔ 1
    GL344099.1(55967-74495)
    African clawed frog
    (Xenopus laevis)
    Amphibia brd2-A-prov2 bromodomain containing 2 77.56(n)    BC043784.1 
    zebrafish
    (Danio rerio)
    Actinopterygii brd2a1 bromodomain-containing 2a 61.53(n)
    64.59(a)
      30445  NM_131200.2  NP_571275.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta fs(1)h3 regulation of transcription from Pol II
    promoter more
    56(a)     --
    rice
    (Oryza sativa)
    Liliopsida Os.371252 Oryza sativa (japonica cultivar-group) cDNA clone0 more 75.92(n)    NM_188433.1 


    ENSEMBL Gene Tree for BRD2 (if available)
    TreeFam Gene Tree for BRD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BRD2 gene
    BRDT2  BRD42  CREBBP2  EP3002  BRD32  
    5 SIMAP similar genes for BRD2 using alignment to 9 protein entries:     BRD2_HUMAN (see all proteins):
    DKFZp313H139    DKFZp686N0336    BRDT    BRD3    BRD4

    Find genes that share paralogs with BRD2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BRD2 (see all 643)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0419124
    A glioblastoma multiforme sample4--see VAR_0419122 P L mis40--------
    VAR_0419044
    A glioblastoma multiforme sample4--see VAR_0419042 G E mis40--------
    VAR_0419094
    A gastric adenocarcinoma sample4--see VAR_0419092 R G mis40--------
    rs1389575501,2
    C--32681400(+) GCGTGG/TGGGGG 1 -- us2k10--------
    rs2067851,2
    C,F,A,H--32934441(+) ttgagG/Acacta 1 -- us2k122Minor allele frequency- A:0.36NS EA WA NA CSA 2341
    rs558069371,2
    C--32934659(+) CATTAC/TTCAGG 1 -- us2k10--------
    rs1161333131,2
    C,F--32934670(+) ACAACA/TGAAGA 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs728658621,2
    C--32934983(+) GAAGTC/TAAGGG 1 -- us2k12Minor allele frequency- T:0.03NA 122
    rs1152497871,2
    C,F--32935148(+) AGCTTG/AAAGAG 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs2067861,2
    C,F,A,H--32935179(+) gtgacA/Caagaa 1 -- us2k129Minor allele frequency- C:0.39MN NS EA NA WA CSA 3540

    HapMap Linkage Disequilibrium report for BRD2 (32936437 - 32949282 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for BRD2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv483081CNV Loss15286789
    nsv527280CNV Loss19592680
    nsv830633CNV Loss17160897
    nsv819221CNV Gain19587683
    dgv1937e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601540    OMIM disorders: --

    1 disease for BRD2:    
    About MalaCards
    photosensitive epilepsy

    1 disease from the University of Copenhagen DISEASES database for BRD2:
    Idiopathic generalized epilepsy

    Find genes that share disorders with BRD2           About GenesLikeMe

    3 Novoseek inferred disease relationships for BRD2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myoclonic epilepsy juvenile 78.2 3 19953286 (1), 12830434 (1)
    leukemia 24.9 3 10934046 (1), 10965846 (1), 9367677 (1)
    cancer 0 1 10704737 (1)

    Genetic Association Database (GAD): BRD2
    Human Genome Epidemiology (HuGE) Navigator: BRD2 (7 documents)

    Export disorders for BRD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BRD2 gene, integrated from 10 sources (see all 83):
    (articles sorted by number of sources associating them with BRD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A homologue of the Drosophila female sterile homeotic (fsh) gene in the class II region of the human MHC. (PubMed id 1352711)1, 2, 3, 9 Beck S.... Trowsdale J. (DNA Seq. 1992)
    2. Phylogeny and structure of the RING3 gene. (PubMed id 8781126)1, 2, 3, 9 Thorpe K.L.... Beck S. (Immunogenetics 1996)
    3. BRD2 (RING3) is a probable major susceptibility gene for common juvenile myoclonic epilepsy. (PubMed id 12830434)1, 4, 9 Pal D.K....Greenberg D.A. (Am. J. Hum. Genet. 2003)
    4. Association of BRD2 polymorphisms with photoparoxysmal response. (PubMed id 16516380)1, 4, 9 Lorenz S....Stephani U. (Neurosci. Lett. 2006)
    5. BRD2 and TAP-1 genes and juvenile myoclonic epilepsy. (PubMed id 19953286)1, 4, 9 Layouni S....Dogui M. (Neurol. Sci. 2010)
    6. Susceptibility locus for non-obstructive azoospermia is localized within the HLA-DR/DQ subregion: primary role of DQB1*0604. (PubMed id 12366783)1, 4, 9 Matsuzaka Y....Inoko H. (Tissue Antigens 2002)
    7. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Dorak M.T. (Mol. Hum. Reprod. 2010)
    8. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PubMed id 19204726)1, 4 Chapuis J....Lambert J.C. (Mol. Psychiatry 2009)
    9. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
    10. The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription. (PubMed id 18406326)1, 2 LeRoy G.... Flint S.J. (Mol. Cell 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6046 HGNC: 1103 AceView: BRD2 Ensembl:ENSG00000204256 euGenes: HUgn6046
    ECgene: BRD2 H-InvDB: BRD2

    (According to HUGE)
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    HUGE: KIAA9001

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BRD2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BRD2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BRD2 gene:
    Search GeneIP for patents involving BRD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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