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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BRD2 Gene

protein-coding   GIFtS: 62
GCID: GC06P032945

bromodomain containing 2

(Previous name: bromodomain-containing 2 )
 Explore 47 diseases affiliated with
BRD2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for BRD2    

Aliases
for BRD2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Bromodomain Containing 21 2     Really Interesting New Gene 3 Protein2 3
RING31 2 3 5     O27.1.12 3
FSRG11 2 5     FSH2
D6S113E1 2     RNF32
NAT1 2     Bromodomain-Containing Protein 22
Bromodomain-Containing 21 2     Female Sterile Homeotic-Related Gene 12
KIAA90011 3     

External Ids:    HGNC: 11031   Entrez Gene: 60462   Ensembl: ENSG000002042567   OMIM: 6015405   UniProtKB: P254403   

Export aliases for BRD2 gene to outside databases

Previous GC identifers: GC06P032938 GC06P032707 GC06P032983 GC06P033044 GC06P032678 GC06P032944


Summaries
for BRD2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for BRD2:
This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family
of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it
selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the
major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the
protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common
form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for
this gene. (provided by RefSeq, Dec 2010)

UniProtKB/Swiss-Prot: BRD2_HUMAN, P25440
Function: May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and
plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the
CCND1 gene. Plays a role in nucleosome assembly

Gene Wiki entry for BRD2


Genomic Views
for BRD2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  NT_113891.2  NT_167245.1  NT_167246.1  NT_167247.1  NT_167248.1  
NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BRD2 gene promoter:
         TBP   SRY   TFIID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): BRD2 promoter sequence
   Search SABiosciences Chromatin IP Primers for BRD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BRD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

BRD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRD2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P032945:  view genomic region     (about GC identifiers)

Start:
 32,936,437 bp from pter      End:
 32,949,282 bp from pter
Size:
 12,846 bases      Orientation:
 plus strand

6 alternative locations:
Chr6+,ALT_REF_LOCI_4 33,013,323-33,026,162      Chr6+,ALT_REF_LOCI_5 32,884,725-32,894,459      Chr6+,ALT_REF_LOCI_6 32,865,184-32,913,603     
Chr6+,ALT_REF_LOCI_3 32,923,568-32,938,265      Chr6+,ALT_REF_LOCI_2 32,858,771-32,910,810      Chr6+,ALT_REF_LOCI_7 32,956,670-33,019,525     

Proteins
for BRD2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: BRD2_HUMAN, P25440 (See protein sequence)
Recommended Name: Bromodomain-containing protein 2  
Size: 801 amino acids; 88061 Da
Subunit: Homodimer. Interacts with E2F1 and with histone H4 acetylated at 'Lys-13'
Subcellular location: Nucleus (Probable). Note=Detected on chromatin and nucleosomes
Sequence caution: Sequence=AAA68890.1; Type=Erroneous initiation;
6/22 PDB 3D structures from and Proteopedia for BRD2 (see all 22):
1X0J (3D)        2DVQ (3D)        2DVR (3D)        2DVS (3D)        2DVV (3D)        2E3K (3D)    
Secondary accessions: A2AAU0 B0S7P0 B1AZT1 O00699 O00700 Q15310 Q5STC9 Q6P3U2 Q969U4
Alternative splicing: 2 isoforms:  P25440-1   P25440-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BRD2: NX_P25440

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P25440

    • BRD2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001106653.1  NP_001186384.1  NP_001186385.1  NP_005095.1  

    ENSEMBL proteins: 
     ENSP00000363958   ENSP00000464077   ENSP00000411195   ENSP00000363964   ENSP00000436322  
     ENSP00000431514   ENSP00000378702   ENSP00000409613   ENSP00000433751   ENSP00000378704  
     ENSP00000409145   ENSP00000413495  

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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for BRD2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--


    BRD2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for BRD2

    Protein Domains /
    Families
    for BRD2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    BRD2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR018359 Bromodomain_CS
     IPR001487 Bromodomain

    Graphical View of Domain Structure for InterPro Entry P25440

    ProtoNet protein and cluster: P25440

    1 Blocks protein family: IPB001487 Bromodomain signature

    UniProtKB/Swiss-Prot: BRD2_HUMAN, P25440
    Domain: One bromodomain is sufficient for a partial interaction with histone H4 acetylated at 'Lys-13'
    Similarity: Contains 2 bromo domains
    Similarity: Contains 1 NET domain


    Function
    for BRD2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: BRD2_HUMAN, P25440
    Function: May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and
    plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the
    CCND1 gene. Plays a role in nucleosome assembly

    miRNA
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    hsa-miR-3678-3p hsa-miR-495 hsa-miR-185* hsa-miR-3193 hsa-miR-658 hsa-miR-486-3p hsa-miR-373* hsa-miR-3150a-3p
    SwitchGear 3'UTR luciferase reporter plasmid: BRD2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BRD2 (see all 7)
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IDA18406326
    GO:0070577histone acetyl-lysine binding IDA18406326


    BRD2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for BRD2:
     Decreased substrate adherent c  Upregulation of Wnt/beta-caten 

    Animal Models:
         11 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Brd2):
     adipose tissue  behavior/neurological  cellular  embryogenesis  endocrine/exocrine gland 
     growth/size  homeostasis/metabolism  immune system  liver/biliary system  mortality/aging 
     nervous system 

    BRD2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for BRD2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Wnt / Hedgehog / Notch
    		Wnt / Hedgehog / Notch1.00
    2Cell Cycle / Checkpoint Control
    		Cell Cycle / Checkpoint Control1.00
    3Regulation of retinoblastoma protein
    		Regulation of retinoblastoma protein1.00
    4Chromatin Regulation / Acetylation
    		Chromatin Regulation / Acetylation1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for BRD2
        Chromatin Regulation / Acetylation
    Wnt / Hedgehog / Notch
    Cell Cycle / Checkpoint Control

    1 BioSystems Pathway for BRD2 
        Regulation of retinoblastoma protein



    BRD2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BRD2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/548 Interacting proteins for BRD2 (P254402, 3 ENSP000003639584) via UniProtKB, MINT, STRING, and/or I2D (see all 548)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4LP628052, 3, ENSP000003482584MINT-7989539 MINT-7989824 MINT-7989882 MINT-7989846 MINT-7989865 I2D: score=3 STRING: ENSP00000348258
    HIST1H4AP628052, 3MINT-7989539 MINT-7989824 MINT-7989882 MINT-7989846 MINT-7989865 I2D: score=3 
    HIST1H4BP628052, 3MINT-7989539 MINT-7989824 MINT-7989882 MINT-7989846 MINT-7989865 I2D: score=3 
    HIST1H4CP628052, 3MINT-7989539 MINT-7989824 MINT-7989882 MINT-7989846 MINT-7989865 I2D: score=3 
    HIST1H4DP628052, 3MINT-7989539 MINT-7989824 MINT-7989882 MINT-7989846 MINT-7989865 I2D: score=3 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IMP18406326
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter IDA18406326
    GO:0007283spermatogenesis TAS9693039
    GO:0016568chromatin modification IEA--


    BRD2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for BRD2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BRD2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Compounds for BRD2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PFI 1BET bromodomain inhibitor--
    2 Novoseek chemical compound relationships for BRD2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sulfadiazine 58 1 9288889 (1)
    dihydrofolate 44.9 1 10965846 (1)

    Search CenterWatch for drugs/clinical trials and news about BRD2 

    Transcripts
    for BRD2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for BRD2 gene (4 alternative transcripts): 
    NM_001113182.2  NM_001199455.1  NM_001199456.1  NM_005104.3  

    Unigene Cluster for BRD2:

    Bromodomain containing 2
    Hs.75243  [show with all ESTs]
    Unigene Representative Sequence: NM_005104
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000374825(uc003ocn.4) ENST00000496118 ENST00000456339 ENST00000580234
    ENST00000584808 ENST00000374831(uc003oco.3 uc003ocq.4) ENST00000581002
    ENST00000495733(uc010jug.1) ENST00000482914(uc003ocp.4) ENST00000395287
    ENST00000449025(uc021ywf.1) ENST00000464592 ENST00000481259 ENST00000463639
    ENST00000469132 ENST00000482838 ENST00000395289(uc010juh.3) ENST00000449085


    miRNA
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    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate BRD2 (see all 30):
    hsa-miR-3678-3p hsa-miR-495 hsa-miR-185* hsa-miR-3193 hsa-miR-658 hsa-miR-486-3p hsa-miR-373* hsa-miR-3150a-3p
    SwitchGear 3'UTR luciferase reporter plasmid: BRD2 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK056504.1 AK309797.1 AL832722.1 BC000477.2 BC001885.1 BC007715.2 BC063840.1 BX647233.1 
    BX648109.1 D42040.1 M80613.1 NR_037625.1 X62083.1 

    24/49 DOTS entries (see all 49):

    DT.454148  DT.95370594  DT.100059484  DT.100059487  DT.95370733  DT.95084310  DT.95326043  DT.100868168 
    DT.95323729  DT.91740239  DT.86848798  DT.101987490  DT.91769504  DT.91724106  DT.121352652  DT.95370608 
    DT.100858555  DT.100876074  DT.100868170  DT.121352622  DT.121352491  DT.121352550  DT.121352563  DT.91924655 

    24/889 AceView cDNA sequences (see all 889):

    BC000477 AU130987 BM695466 AI763359 BQ019304 CB241494 R46360 BQ941561 
    BM783052 AW327803 BX421462 BG389662 BQ018124 BI333080 BM824518 BU173792 
    BC001885 BX951281 BE855916 AA805043 CA748483 AI918268 BM821855 AW130899 

    GeneLoc Exon Structure


    Expression
    for BRD2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BRD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGGAGGGAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See BRD2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BRD2

    SOURCE GeneReport for Unigene cluster: Hs.75243
        SABiosciences Expression via Pathway-Focused PCR Arrays including BRD2: 
              TGFB Signaling Targets in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for BRD2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for BRD2 gene from 8/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves BRD21 bromodomain containing 2 73.56(n)
    84.33(a)    		   417049  NM_001030674.1  NP_001025845.1 
    lizard
    (Anolis carolinensis)    		 Reptilia BRD26
    		 --
    		 73(a)
    		 1 ↔ 1
    		 GL344099.1(55967-68352)
    African clawed frog
    (Xenopus laevis)    		 Amphibia brd2-A-prov2 bromodomain containing 2 77.56(n)    BC043784.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii brd2a1 bromodomain-containing 2a 62.13(n)
    66.1(a)    		   30445  NM_131200.1  NP_571275.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta fs(1)h3 regulation of transcription from Pol II
    promoter more    		 56(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea bet-26
    bet-16
    		 Protein BET-2, isoform a
    Temporarily Assigned Gene name family member (tag-...
    		 8(a)
    13(a)
    		 possible ortholog
    possible ortholog
    		 X(10569057-10575659)
    I(4526379-4534801)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons NPX16
    GTE36
    (see all 12)    		 bromodomain-containing protein GTE3
    (see all 12)    		 8(a)
    23(a)
    (see all 12)    		 possible ortholog
    many ↔ many
    (see all 12)    		 5(25374413-25379297)
    1(27504112-27506112)
    rice
    (Oryza sativa)    		 Liliopsida Os.371252 Oryza sativa (japonica cultivar-group) cDNA clone0 more 75.92(n)    NM_188433.1 


    ENSEMBL Gene Tree for BRD2 (if available)
    TreeFam Gene Tree for BRD2 (if available) 

    Paralogs
    for BRD2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BRD2 gene
    BRDT2  BRD42  CREBBP2  EP3002  BRD32  
    13 SIMAP similar genes for BRD2 using alignment to 16 protein entries:     BRD2_HUMAN (see all proteins):
    DKFZp313H139    DKFZp686N0336    NF2    BRDT    BRD3    FAM175A
    AURA2    UTY    ZNF564    BRD4    SHANK2    LINC00596
    ZNF74

    BRD2 for paralogs           About GeneDecksing



    Genomic Variants
    for BRD2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/565 NCBI SNPs in BRD2 are shown (see all 565)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2067851,2
    		C,F,A,H,--32934441(+) ttgagG/Acacta 1 -- us2k122Minor allele frequency- A:0.36NS EA WA NA CSA 2341
    rs558069371,2
    		C--32934659(+) CATTAC/TTCAGG 1 -- us2k10--------
    rs1161333131,2
    		F,--32934670(+) ACAACA/TGAAGA 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs728658621,2
    		C,--32934983(+) GAAGTC/TAAGGG 1 -- us2k12Minor allele frequency- T:0.03NA 122
    rs1152497871,2
    		C,F,--32935148(+) AGCTTG/AAAGAG 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs2067861,2
    		C,F,A,H,--32935179(+) gtgacA/Caagaa 1 -- us2k129Minor allele frequency- C:0.39MN NS EA NA WA CSA 3540
    rs1144902291,2
    		F,--32935185(+) AAGAAT/CTGAGA 1 -- us2k12Minor allele frequency- C:0.02WA NA 238
    rs119641881,2
    		C,F,H,--32935208(+) TTTCAA/GTTTCA 1 -- us2k1 tfbs37Minor allele frequency- G:0.09NS EA WA NA 778
    rs1886190361,2
    		--32935258(+) TAAGAC/GGGCAC 1 -- us2k10--------
    rs1472178991,2
    		--32935300(+) CGGGGA/GAACCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for BRD2 (32936437 - 32949282 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for BRD2
         2 CNVs: 0076 3604
         1 Indel: 59333

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    Disorders / Diseases
    for BRD2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    BRD2 for disorders           About GeneDecksing

    OMIM gene information: 601540    OMIM disorders: --

    20/47 diseases for BRD2 (see all 47):    About MalaCards
    juvenile myoclonic epilepsy    irregular astigmatism    mccune albright syndrome    androgen insensitivity syndrome
    photoparoxysmal response    gonadal dysgenesis    pituitary apoplexy    precocious puberty
    delayed puberty    spontaneous abortion    premature ovarian failure    astigmatism
    ovarian hyperstimulation syndrome    b-cell lymphomas    polycystic ovary syndrome    leydig cell tumor
    generalized epilepsy    systemic lupus erythematosus    lupus erythematosus    anovulation

    1 disease from the University of Copenhagen DISEASES database for BRD2:
    Idiopathic generalized epilepsy

    3 Novoseek disease relationships for BRD2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myoclonic epilepsy juvenile 78.2 3 19953286 (1), 12830434 (1)
    leukemia 24.9 3 10934046 (1), 10965846 (1), 9367677 (1)
    cancer 0 1 10704737 (1)

    Genetic Association Database (GAD): BRD2
    Human Genome Epidemiology (HuGE) Navigator: BRD2 (7 documents)

    Export disorders for BRD2 gene to outside databases

    Publications
    for BRD2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BRD2 gene, integrated from 9 sources (see all 75):
    (articles sorted by number of sources associating them with BRD2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A homologue of the Drosophila female sterile homeotic (fsh) gene in the class II region of the human MHC. (PubMed id 1352711)1, 2, 3, 9 Beck S.... Trowsdale J. (1992)
    2. Phylogeny and structure of the RING3 gene. (PubMed id 8781126)1, 2, 3, 9 Thorpe K.L....Beck S. (1996)
    3. BRD2 (RING3) is a probable major susceptibility gene for common juvenile myoclonic epilepsy. (PubMed id 12830434)1, 4, 9 Pal D.K....Greenberg D.A. (2003)
    4. Susceptibility locus for non-obstructive azoospermia is localized within the HLA-DR/DQ subregion: primary role of DQB1*0604. (PubMed id 12366783)1, 4, 9 Matsuzaka Y....Inoko H. (2002)
    5. The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription. (PubMed id 18406326)1, 2 LeRoy G....Flint S.J. (2008)
    6. Crystal structure of the human BRD2 bromodomain: insights into dimerization and recognition of acetylated histone h4. (PubMed id 17148447)1, 2 Nakamura Y.... Yokoyama S. (2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    9. Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein. (PubMed id 12145330)1, 9 Crowley T.E....Wolgemuth D.J. (2002)
    10. Nucleotide sequence of the ring3 gene in the class II region of the mouse MHC and its abundant expression in testicular germ cells. (PubMed id 9693039)1, 9 Taniguchi Y....Inoko H. (1998)

    External Searches for BRD2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing BRD2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6046 HGNC: 1103 AceView: BRD2 Ensembl:ENSG00000204256 euGenes: HUgn6046
    ECgene: BRD2 H-InvDB: BRD2

    Other Databases showing BRD2 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA9001

    Specialized Databases showing BRD2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BRD2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BRD2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for BRD2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for BRD2 gene:
    Search GeneIP for patents involving BRD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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