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Aliases for BRD2 Gene

Aliases for BRD2 Gene

  • Bromodomain Containing 2 2 3 5
  • Really Interesting New Gene 3 Protein 3 4
  • O27.1.1 3 4
  • RING3 3 4
  • Female Sterile Homeotic-Related Gene 1 3
  • Bromodomain-Containing 2 2
  • KIAA9001 4
  • D6S113E 3
  • FSRG1 3
  • RNF3 3
  • FSH 3
  • NAT 3

External Ids for BRD2 Gene

Previous GeneCards Identifiers for BRD2 Gene

  • GC06P032938
  • GC06P032707
  • GC06P032983
  • GC06P033044
  • GC06P032678
  • GC06P032944
  • GC06P032945
  • GC06P032949

Summaries for BRD2 Gene

Entrez Gene Summary for BRD2 Gene

  • This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for BRD2 Gene

BRD2 (Bromodomain Containing 2) is a Protein Coding gene. Diseases associated with BRD2 include Epilepsy, Generalized, With Febrile Seizures Plus, Type 5. Among its related pathways are Regulation of retinoblastoma protein and DNA Damage. GO annotations related to this gene include chromatin binding and lysine-acetylated histone binding. An important paralog of this gene is BRD3.

UniProtKB/Swiss-Prot for BRD2 Gene

  • May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.

Tocris Summary for BRD2 Gene

  • Bromodomains (BRDs) are epigenetic reader domains that selectively recognize acetylated lysine residues on the tails of histone proteins, and are the only known protein modules that can target acetylated lysine residues.

Gene Wiki entry for BRD2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRD2 Gene

Genomics for BRD2 Gene

Regulatory Elements for BRD2 Gene

Enhancers for BRD2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BRD2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the BRD2 gene promoter:

Genomic Location for BRD2 Gene

Chromosome:
6
Start:
32,968,660 bp from pter
End:
32,981,505 bp from pter
Size:
12,846 bases
Orientation:
Plus strand

Genomic View for BRD2 Gene

Genes around BRD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for BRD2 Gene

  • Protein details for BRD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25440-BRD2_HUMAN
    Recommended name:
    Bromodomain-containing protein 2
    Protein Accession:
    P25440
    Secondary Accessions:
    • A2AAU0
    • B0S7P0
    • B1AZT1
    • O00699
    • O00700
    • Q15310
    • Q5STC9
    • Q63HQ9
    • Q658Y7
    • Q6P3U2
    • Q969U4

    Protein attributes for BRD2 Gene

    Size:
    801 amino acids
    Molecular mass:
    88061 Da
    Quaternary structure:
    • Homodimer. Interacts with E2F1 and with histone H4 acetylated at Lys-13.
    SequenceCaution:
    • Sequence=AAA68890.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BRD2 Gene

    Alternative splice isoforms for BRD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BRD2 Gene

Proteomics data for BRD2 Gene at MOPED

Post-translational modifications for BRD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for BRD2 Gene

Domains & Families for BRD2 Gene

Gene Families for BRD2 Gene

Protein Domains for BRD2 Gene

Graphical View of Domain Structure for InterPro Entry

P25440

UniProtKB/Swiss-Prot:

BRD2_HUMAN :
  • One bromodomain is sufficient for a partial interaction with histone H4 acetylated at Lys-13.
Domain:
  • One bromodomain is sufficient for a partial interaction with histone H4 acetylated at Lys-13.
  • Contains 2 bromo domains.
  • Contains 1 NET domain.
genes like me logo Genes that share domains with BRD2: view

Function for BRD2 Gene

Molecular function for BRD2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.

Gene Ontology (GO) - Molecular Function for BRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 20709061
genes like me logo Genes that share ontologies with BRD2: view
genes like me logo Genes that share phenotypes with BRD2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for BRD2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BRD2 Gene

Localization for BRD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRD2 Gene

Nucleus. Note=Detected on chromatin and nucleosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BRD2 Gene COMPARTMENTS Subcellular localization image for BRD2 gene
Compartment Confidence
nucleus 4

No data available for Gene Ontology (GO) - Cellular Components for BRD2 Gene

Pathways & Interactions for BRD2 Gene

genes like me logo Genes that share pathways with BRD2: view

Pathways by source for BRD2 Gene

3 Cell Signaling Technology pathways for BRD2 Gene
1 BioSystems pathway for BRD2 Gene

Gene Ontology (GO) - Biological Process for BRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IMP 18406326
GO:0007283 spermatogenesis TAS 9693039
genes like me logo Genes that share ontologies with BRD2: view

No data available for SIGNOR curated interactions for BRD2 Gene

Drugs & Compounds for BRD2 Gene

(21) Drugs for BRD2 Gene - From: ApexBio, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
I-BET-762 Pharma BET inhibitor,highly potent 0
CPI-203 Pharma BET bromodomain inhibitor 0
I-BET151 (GSK1210151A) Pharma Selective BET inhibitor 0
MS436 Pharma BRD4 inhibitor 0
OF-1 Pharma BRPF1B and BRPF2 bromodomain inhibitor 0

(5) Additional Compounds for BRD2 Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
I-BET 151 dihydrochloride
Ischemin sodium salt
LY 303511
154447-38-8
PFI 1
1403764-72-6

(5) Tocris Compounds for BRD2 Gene

Compound Action Cas Number
(+)-JQ1 Potent, selective BET bromodomain inhibitor; cell permeable 1268524-70-4
I-BET 151 dihydrochloride BET bromodomain inhibitor; also promotes differentiation of hiPSCs into megakaryocytes
Ischemin sodium salt CBP inhibitor; cell permeable
LY 303511 Negative control of LY 294002 (Cat. No. 1130) 154447-38-8
PFI 1 BET bromodomain inhibitor 1403764-72-6

(10) ApexBio Compounds for BRD2 Gene

Compound Action Cas Number
CPI-203 BET bromodomain inhibitor 1446144-04-2
I-BET151 (GSK1210151A) Selective BET inhibitor 1300031-49-5
I-BET-762 BET inhibitor,highly potent 1260907-17-2
MS436 BRD4 inhibitor 1395084-25-9
OF-1 BRPF1B and BRPF2 bromodomain inhibitor 919973-83-4
OTX-015 BRD inhibitor 202590-98-5
PFI-1 (PF-6405761) BET inhibitor 1403764-72-6
RVX-208 Potent BET bromodomain inhibitor 1044870-39-4
UNC1215 Chemical probe for the methyllysine (Kme) 1415800-43-9
UNC669 L3MBTL antagonist,potent and selective 1314241-44-5
genes like me logo Genes that share compounds with BRD2: view

Transcripts for BRD2 Gene

Unigene Clusters for BRD2 Gene

Bromodomain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BRD2 Gene

No ASD Table

Relevant External Links for BRD2 Gene

GeneLoc Exon Structure for
BRD2
ECgene alternative splicing isoforms for
BRD2

Expression for BRD2 Gene

mRNA expression in normal human tissues for BRD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BRD2 Gene

This gene is overexpressed in CD8 Tcells (18.8) and Liver, secretome (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BRD2 Gene



SOURCE GeneReport for Unigene cluster for BRD2 Gene Hs.75243

genes like me logo Genes that share expression patterns with BRD2: view

Protein tissue co-expression partners for BRD2 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BRD2 Gene

Orthologs for BRD2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BRD2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BRD2 35
  • 89.32 (n)
  • 95.74 (a)
BRD2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BRD2 35
  • 89.66 (n)
  • 95.74 (a)
BRD2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Brd2 35
  • 87.72 (n)
  • 95.59 (a)
Brd2 16
Brd2 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BRD2 35
  • 98.02 (n)
  • 98.58 (a)
BRD2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Brd2 35
  • 87.51 (n)
  • 95.33 (a)
oppossum
(Monodelphis domestica)
Mammalia BRD2 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 35 (a)
ManyToMany
chicken
(Gallus gallus)
Aves BRD2 35
  • 71.54 (n)
  • 80.92 (a)
BRD2 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BRD2 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia brd2 35
  • 67.65 (n)
  • 74.41 (a)
Str.10243 35
African clawed frog
(Xenopus laevis)
Amphibia brd2-A-prov 35
zebrafish
(Danio rerio)
Actinopterygii brd2a 35
  • 61.53 (n)
  • 64.59 (a)
brd2a 36
  • 59 (a)
OneToMany
brd2b 36
  • 54 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.506 35
fruit fly
(Drosophila melanogaster)
Insecta fs(1)h 37
  • 56 (a)
fs(1)h 36
  • 18 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.37125 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToMany
Species with no ortholog for BRD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRD2 Gene

ENSEMBL:
Gene Tree for BRD2 (if available)
TreeFam:
Gene Tree for BRD2 (if available)

Paralogs for BRD2 Gene

Paralogs for BRD2 Gene

genes like me logo Genes that share paralogs with BRD2: view

Variants for BRD2 Gene

Sequence variations from dbSNP and Humsavar for BRD2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs176250 - 32,976,351(-) GTTGA(A/G)GACAG nc-transcript-variant, reference, missense
rs3918143 - 32,977,848(+) CTTGG(C/T)CAAAT nc-transcript-variant, reference, missense
rs1049369 - 32,978,187(+) Caaga(A/G)gaaaa nc-transcript-variant, reference, missense
VAR_041904 A glioblastoma multiforme sample
VAR_041905 -

Structural Variations from Database of Genomic Variants (DGV) for BRD2 Gene

Variant ID Type Subtype PubMed ID
nsv830633 CNV Loss 17160897
nsv483081 CNV Loss 15286789
dgv1937e1 CNV Complex 17122850
nsv527280 CNV Loss 19592680
nsv819221 CNV Gain 19587683

Variation tolerance for BRD2 Gene

Residual Variation Intolerance Score: 2.78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.26; 76.35% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for BRD2 Gene

Disorders for BRD2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for BRD2 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
epilepsy, generalized, with febrile seizures plus, type 5
  • epilepsy, idiopathic generalized, 10
- elite association - COSMIC cancer census association via MalaCards
Search BRD2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BRD2

Genetic Association Database (GAD)
BRD2
Human Genome Epidemiology (HuGE) Navigator
BRD2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BRD2
genes like me logo Genes that share disorders with BRD2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BRD2 Gene

Publications for BRD2 Gene

  1. A homologue of the Drosophila female sterile homeotic (fsh) gene in the class II region of the human MHC. (PMID: 1352711) Beck S. … Trowsdale J. (DNA Seq. 1992) 2 3 4 23 67
  2. Phylogeny and structure of the RING3 gene. (PMID: 8781126) Thorpe K.L. … Beck S. (Immunogenetics 1996) 2 3 23
  3. BRD2 and TAP-1 genes and juvenile myoclonic epilepsy. (PMID: 19953286) Layouni S. … Dogui M. (Neurol. Sci. 2010) 3 23
  4. Association of BRD2 polymorphisms with photoparoxysmal response. (PMID: 16516380) Lorenz S. … Stephani U. (Neurosci. Lett. 2006) 3 23
  5. E mu-BRD2 transgenic mice develop B-cell lymphoma and leukemia. (PMID: 14563639) Greenwald R.J. … Denis G.V. (Blood 2004) 3 23

Products for BRD2 Gene

Sources for BRD2 Gene

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