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Aliases for BRD2 Gene

Aliases for BRD2 Gene

  • Bromodomain Containing 2 2 3 5
  • Really Interesting New Gene 3 Protein 3 4
  • O27.1.1 3 4
  • RING3 3 4
  • Female Sterile Homeotic-Related Gene 1 3
  • Bromodomain-Containing Protein 2 3
  • Bromodomain-Containing 2 2
  • KIAA9001 4
  • D6S113E 3
  • FSRG1 3
  • RNF3 3
  • FSH 3
  • NAT 3

External Ids for BRD2 Gene

Previous GeneCards Identifiers for BRD2 Gene

  • GC06P032938
  • GC06P032707
  • GC06P032983
  • GC06P033044
  • GC06P032678
  • GC06P032944
  • GC06P032945
  • GC06P032949

Summaries for BRD2 Gene

Entrez Gene Summary for BRD2 Gene

  • This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for BRD2 Gene

BRD2 (Bromodomain Containing 2) is a Protein Coding gene. Diseases associated with BRD2 include Epilepsy, Generalized, With Febrile Seizures Plus, Type 5 and Prolapse Of Female Genital Organ. Among its related pathways are Regulation of retinoblastoma protein and Wnt / Hedgehog / Notch. GO annotations related to this gene include chromatin binding and lysine-acetylated histone binding. An important paralog of this gene is BRD3.

UniProtKB/Swiss-Prot for BRD2 Gene

  • May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.

Tocris Summary for BRD2 Gene

  • Bromodomains (BRDs) are epigenetic reader domains that selectively recognize acetylated lysine residues on the tails of histone proteins, and are the only known protein modules that can target acetylated lysine residues.

Gene Wiki entry for BRD2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRD2 Gene

Genomics for BRD2 Gene

Regulatory Elements for BRD2 Gene

Enhancers for BRD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F032965 1.2 ENCODE 94.9 +2.0 2009 10.4 CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 NFYC BRD2 VPS52 ATF6B LEMD2 RING1 RXRB DAXX MIR6873 HCG25 PPT2
GH06F033409 0.2 ENCODE 81.1 +442.4 442402 4.1 CREB3L1 MLX ZFP64 DMAP1 SLC30A9 ZNF263 SP3 NFYC MEF2D ZNF610 BRD2 VPS52 HCG25 RING1 LEMD2 RXRB DAXX MIR6873 ITPR3 MIR5004
GH06F033183 0.5 Ensembl ENCODE 72.5 +214.9 214941 1.2 CBX3 ZNF493 ZFP64 NFRKB ZBTB40 YY1 CBX5 ZNF138 ETV6 ZNF202 BRD2 VPS52 HCG25 LEMD2 RING1 MIR6873 RXRB DAXX RPS18 HLA-DPB1
GH06F033016 1.8 FANTOM5 Ensembl ENCODE 65.4 +50.2 50208 5.0 PKNOX1 ZNF493 ARID4B SIN3A ZNF2 YY1 ZNF121 GLIS2 ZNF143 KLF7 HCG25 BRD2 VPS52 LEMD2 ATF6B RXRB RING1 PPT2 MIR6873 DAXX
GH06F033270 1.1 ENCODE 61.6 +306.5 306469 8.4 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 DAXX RPS18 BRD2 VPS52 MIR6873 RGL2 LEMD2 RXRB ITPR3 MIR5004
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around BRD2 on UCSC Golden Path with GeneCards custom track

Genomic Location for BRD2 Gene

Chromosome:
6
Start:
32,968,660 bp from pter
End:
32,981,505 bp from pter
Size:
12,846 bases
Orientation:
Plus strand

Genomic View for BRD2 Gene

Genes around BRD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for BRD2 Gene

  • Protein details for BRD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25440-BRD2_HUMAN
    Recommended name:
    Bromodomain-containing protein 2
    Protein Accession:
    P25440
    Secondary Accessions:
    • A2AAU0
    • B0S7P0
    • B1AZT1
    • O00699
    • O00700
    • Q15310
    • Q5STC9
    • Q63HQ9
    • Q658Y7
    • Q6P3U2
    • Q969U4

    Protein attributes for BRD2 Gene

    Size:
    801 amino acids
    Molecular mass:
    88061 Da
    Quaternary structure:
    • Homodimer. Interacts with E2F1 and with histone H4 acetylated at Lys-13.
    SequenceCaution:
    • Sequence=AAA68890.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BRD2 Gene

    Alternative splice isoforms for BRD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BRD2 Gene

Post-translational modifications for BRD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for BRD2 (BRD2)

No data available for DME Specific Peptides for BRD2 Gene

Domains & Families for BRD2 Gene

Gene Families for BRD2 Gene

Protein Domains for BRD2 Gene

Graphical View of Domain Structure for InterPro Entry

P25440

UniProtKB/Swiss-Prot:

BRD2_HUMAN :
  • One bromodomain is sufficient for a partial interaction with histone H4 acetylated at Lys-13.
Domain:
  • One bromodomain is sufficient for a partial interaction with histone H4 acetylated at Lys-13.
  • Contains 2 bromo domains.
  • Contains 1 NET domain.
genes like me logo Genes that share domains with BRD2: view

Function for BRD2 Gene

Molecular function for BRD2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.

Gene Ontology (GO) - Molecular Function for BRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 18406326
GO:0005515 protein binding IPI 20709061
GO:0070577 lysine-acetylated histone binding IDA 18406326
genes like me logo Genes that share ontologies with BRD2: view
genes like me logo Genes that share phenotypes with BRD2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for BRD2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BRD2 Gene

Localization for BRD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRD2 Gene

Nucleus. Note=Detected on chromatin and nucleosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BRD2 Gene COMPARTMENTS Subcellular localization image for BRD2 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for BRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with BRD2: view

Pathways & Interactions for BRD2 Gene

genes like me logo Genes that share pathways with BRD2: view

Pathways by source for BRD2 Gene

3 Cell Signaling Technology pathways for BRD2 Gene
1 BioSystems pathway for BRD2 Gene

Gene Ontology (GO) - Biological Process for BRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IMP 18406326
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IDA 18406326
GO:0007283 spermatogenesis TAS 9693039
genes like me logo Genes that share ontologies with BRD2: view

No data available for SIGNOR curated interactions for BRD2 Gene

Drugs & Compounds for BRD2 Gene

(33) Drugs for BRD2 Gene - From: ApexBio, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
GW841819X Pharma BET bromodomain inhibitor 0
I-BET-762 Pharma BET inhibitor,highly potent 0
(-)-JQ1 Pharma BET bromodomain inhibitor 0
BAZ2-ICR Pharma 0
BET-BAY 002 Pharma 0

(4) Additional Compounds for BRD2 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
I-BET 151 dihydrochloride
1883545-47-8
I-BRD9
1714146-59-4
NI 42
1884640-99-6

(5) Tocris Compounds for BRD2 Gene

Compound Action Cas Number
(+)-JQ1 Potent, selective BET bromodomain inhibitor; cell permeable 1268524-70-4
I-BET 151 dihydrochloride BET bromodomain inhibitor; also promotes differentiation of hiPSCs into megakaryocytes 1883545-47-8
I-BRD9 Potent and selective BRD9 inhibitor 1714146-59-4
I-CBP 112 Selective CBP/p300 BRD inhibitor
NI 42 High affinity BRPF inhibitor 1884640-99-6

(22) ApexBio Compounds for BRD2 Gene

Compound Action Cas Number
(-)-JQ1 BET bromodomain inhibitor 1268524-71-5
BAZ2-ICR
BET-BAY 002 1588521-78-1
Bromodomain Inhibitor, (+)-JQ1 BET bromodomain inhibitor 1268524-70-4
Bromosporine Bromodomain inhibitor,non-selective 1619994-69-2
CPI-203 BET bromodomain inhibitor 1446144-04-2
GSK 525768A inactive stereoisomer of I-BET-762 1260530-25-3
GSK 5959 901245-65-6
GSK1324726A BET proteins inhibitor 1300031-52-0
GW841819X BET bromodomain inhibitor
I-BET 151 hydrochloride
I-BET151 (GSK1210151A) Selective BET inhibitor 1300031-49-5
I-BET-762 BET inhibitor,highly potent 1260907-17-2
Ischemin sodium salt
MS436 BRD4 inhibitor 1395084-25-9
OF-1 BRPF1B and BRPF2 bromodomain inhibitor 919973-83-4
OTX-015 BRD inhibitor 202590-98-5
OXF BD 02 1429129-68-9
PFI-1 (PF-6405761) BET inhibitor 1403764-72-6
RVX-208 Potent BET bromodomain inhibitor 1044870-39-4
UNC1215 Chemical probe for the methyllysine (Kme) 1415800-43-9
UNC669 L3MBTL antagonist,potent and selective 1314241-44-5
genes like me logo Genes that share compounds with BRD2: view

Transcripts for BRD2 Gene

Unigene Clusters for BRD2 Gene

Bromodomain containing 2:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BRD2 Gene

No ASD Table

Relevant External Links for BRD2 Gene

GeneLoc Exon Structure for
BRD2
ECgene alternative splicing isoforms for
BRD2

Expression for BRD2 Gene

mRNA expression in normal human tissues for BRD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BRD2 Gene

This gene is overexpressed in CD8 Tcells (18.8) and Liver, secretome (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BRD2 Gene



Protein tissue co-expression partners for BRD2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of BRD2 Gene:

BRD2

SOURCE GeneReport for Unigene cluster for BRD2 Gene:

Hs.75243
genes like me logo Genes that share expression patterns with BRD2: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BRD2 Gene

Orthologs for BRD2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BRD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BRD2 34 35
  • 98.02 (n)
oppossum
(Monodelphis domestica)
Mammalia BRD2 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BRD2 34 35
  • 89.66 (n)
cow
(Bos Taurus)
Mammalia BRD2 34 35
  • 89.32 (n)
mouse
(Mus musculus)
Mammalia Brd2 34 16 35
  • 87.72 (n)
rat
(Rattus norvegicus)
Mammalia Brd2 34
  • 87.51 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 35 (a)
ManyToMany
chicken
(Gallus gallus)
Aves BRD2 34 35
  • 71.54 (n)
lizard
(Anolis carolinensis)
Reptilia BRD2 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia brd2 34
  • 67.65 (n)
Str.10243 34
African clawed frog
(Xenopus laevis)
Amphibia brd2-A-prov 34
zebrafish
(Danio rerio)
Actinopterygii brd2a 34 35
  • 61.53 (n)
brd2b 35
  • 54 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.506 34
fruit fly
(Drosophila melanogaster)
Insecta fs(1)h 36 35
  • 56 (a)
rice
(Oryza sativa)
Liliopsida Os.37125 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 47 (a)
OneToMany
Species where no ortholog for BRD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRD2 Gene

ENSEMBL:
Gene Tree for BRD2 (if available)
TreeFam:
Gene Tree for BRD2 (if available)

Paralogs for BRD2 Gene

Paralogs for BRD2 Gene

genes like me logo Genes that share paralogs with BRD2: view

Variants for BRD2 Gene

Sequence variations from dbSNP and Humsavar for BRD2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_041904 A glioblastoma multiforme sample
VAR_041909 A gastric adenocarcinoma sample
VAR_041912 A glioblastoma multiforme sample
rs864309591 Uncertain significance 32,974,467(+) GCTCC(C/T)TGGGG nc-transcript-variant, reference, missense, utr-variant-5-prime
rs10484568 -- 32,967,974(+) TACGA(A/G)ATAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for BRD2 Gene

Variant ID Type Subtype PubMed ID
esv2759417 CNV gain 17122850
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1119076 CNV deletion 24896259
nsv483081 CNV loss 15286789
nsv527280 CNV loss 19592680
nsv602817 CNV loss 21841781
nsv819221 CNV gain 19587683
nsv830633 CNV loss 17160897

Variation tolerance for BRD2 Gene

Residual Variation Intolerance Score: 2.78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.26; 76.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BRD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
BRD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRD2 Gene

Disorders for BRD2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for BRD2 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
epilepsy, generalized, with febrile seizures plus, type 5
  • epilepsy, idiopathic generalized, 10
prolapse of female genital organ
enterocele
  • vaginal enterocele
- elite association - COSMIC cancer census association via MalaCards
Search BRD2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for BRD2

Genetic Association Database (GAD)
BRD2
Human Genome Epidemiology (HuGE) Navigator
BRD2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BRD2
genes like me logo Genes that share disorders with BRD2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BRD2 Gene

Publications for BRD2 Gene

  1. Phylogeny and structure of the RING3 gene. (PMID: 8781126) Thorpe K.L. … Beck S. (Immunogenetics 1996) 2 3 4 22 64
  2. A homologue of the Drosophila female sterile homeotic (fsh) gene in the class II region of the human MHC. (PMID: 1352711) Beck S. … Trowsdale J. (DNA Seq. 1992) 2 3 4 22 64
  3. BRD2 and TAP-1 genes and juvenile myoclonic epilepsy. (PMID: 19953286) Layouni S. … Dogui M. (Neurol. Sci. 2010) 3 22 46 64
  4. Association of BRD2 polymorphisms with photoparoxysmal response. (PMID: 16516380) Lorenz S. … Stephani U. (Neurosci. Lett. 2006) 3 22 46 64
  5. BRD2 (RING3) is a probable major susceptibility gene for common juvenile myoclonic epilepsy. (PMID: 12830434) Pal D.K. … Greenberg D.A. (Am. J. Hum. Genet. 2003) 3 22 46 64

Products for BRD2 Gene

Sources for BRD2 Gene

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