Aliases for BRD2 Gene
External Ids for BRD2 Gene
This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010]
GeneCards Summary for BRD2 Gene
BRD2 (Bromodomain Containing 2) is a Protein Coding gene. Diseases associated with BRD2 include photosensitive epilepsy. Among its related pathways are Cell Cycle / Checkpoint Control and Wnt / Hedgehog / Notch. GO annotations related to this gene include chromatin binding and lysine-acetylated histone binding. An important paralog of this gene is BRD4.
UniProtKB/Swiss-Prot for BRD2 Gene
May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.
Bromodomains (BRDs) are epigenetic readers that selectively recognize acetylated lysine (Kac) residues on histone protein tails, and are the only known protein modules that target Kac residues. There are approximately 62 unique human bromodomains, most of which can be classified according to sequence identity into nine groups.