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Aliases for BRD1 Gene

Aliases for BRD1 Gene

  • Bromodomain Containing 1 2 3
  • BRL 3 4 6
  • Bromodomain And PHD Finger-Containing Protein 2 3 4
  • BR140-Like Protein 3 4
  • BRPF2 3 4
  • Bromodomain-Containing Protein 1 3
  • Bromodomain-Containing 1 2
  • BR140-Like 2
  • BRPF1 3

External Ids for BRD1 Gene

Previous GeneCards Identifiers for BRD1 Gene

  • GC22M046756
  • GC22M048386
  • GC22M048487
  • GC22M048552
  • GC22M050166
  • GC22M033113

Summaries for BRD1 Gene

Entrez Gene Summary for BRD1 Gene

  • This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4, thereby potentially playing a role in gene activation. Variation in this gene is associated with schozophrenia and bipolar disorder in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for BRD1 Gene

BRD1 (Bromodomain Containing 1) is a Protein Coding gene. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening. GO annotations related to this gene include histone binding. An important paralog of this gene is PHF14.

UniProtKB/Swiss-Prot for BRD1 Gene

  • Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRD1 Gene

Genomics for BRD1 Gene

Regulatory Elements for BRD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BRD1 Gene

Start:
49,773,283 bp from pter
End:
49,827,548 bp from pter
Size:
54,266 bases
Orientation:
Minus strand

Genomic View for BRD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BRD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRD1 Gene

Proteins for BRD1 Gene

  • Protein details for BRD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95696-BRD1_HUMAN
    Recommended name:
    Bromodomain-containing protein 1
    Protein Accession:
    O95696
    Secondary Accessions:
    • A6ZJA4

    Protein attributes for BRD1 Gene

    Size:
    1058 amino acids
    Molecular mass:
    119520 Da
    Quaternary structure:
    • Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. Interacts (via PHD-type zinc finger domain) with unmodified histone H3. Interacts (via PWWP domain) with dimethylated and trimethylated Lys-79 on histone H3.

    Three dimensional structures from OCA and Proteopedia for BRD1 Gene

    Alternative splice isoforms for BRD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BRD1 Gene

Proteomics data for BRD1 Gene at MOPED

Post-translational modifications for BRD1 Gene

  • Ubiquitination at Lys368
  • Modification sites at PhosphoSitePlus

Other Protein References for BRD1 Gene

No data available for DME Specific Peptides for BRD1 Gene

Domains for BRD1 Gene

Suggested Antigen Peptide Sequences for BRD1 Gene

Graphical View of Domain Structure for InterPro Entry

O95696

UniProtKB/Swiss-Prot:

BRD1_HUMAN :
  • O95696
Domain:
  • Contains 1 bromo domain.
  • Contains 1 PWWP domain.
Similarity:
  • Contains 1 PHD-type zinc finger.
genes like me logo Genes that share domains with BRD1: view

No data available for Gene Families for BRD1 Gene

Function for BRD1 Gene

Molecular function for BRD1 Gene

UniProtKB/Swiss-Prot Function:
Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.

Gene Ontology (GO) - Molecular Function for BRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0042393 histone binding IDA 21880731
genes like me logo Genes that share ontologies with BRD1: view
genes like me logo Genes that share phenotypes with BRD1: view

Animal Models for BRD1 Gene

MGI Knock Outs for BRD1:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BRD1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BRD1 Gene

Localization for BRD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRD1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BRD1 Gene COMPARTMENTS Subcellular localization image for BRD1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for BRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10602503
GO:0005654 nucleoplasm IDA --
GO:0070776 MOZ/MORF histone acetyltransferase complex IDA 16387653
genes like me logo Genes that share ontologies with BRD1: view

Pathways for BRD1 Gene

genes like me logo Genes that share pathways with BRD1: view

Pathways by source for BRD1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Epigenetic Chromatin Remodeling Factors in human,mouse,rat

Gene Ontology (GO) - Biological Process for BRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043966 histone H3 acetylation IDA 16387653
genes like me logo Genes that share ontologies with BRD1: view

Compounds for BRD1 Gene

(9) ApexBio Compounds for BRD1 Gene

Compound Action Cas Number
CPI-203 BET bromodomain inhibitor [1446144-04-2]
I-BET151 (GSK1210151A) Selective BET inhibitor [1300031-49-5]
I-BET-762 "BET inhibitor,highly potent" [1260907-17-2]
MS436 BRD4 inhibitor [1395084-25-9]
OF-1 BRPF1B and BRPF2 bromodomain inhibitor [919973-83-4]
PFI-1 (PF-6405761) BET inhibitor [1403764-72-6]
RVX-208 Potent BET bromodomain inhibitor [1044870-39-4]
UNC1215 Chemical probe for the methyllysine (Kme) [1415800-43-9]
UNC669 "L3MBTL antagonist,potent and selective" [1314241-44-5]
genes like me logo Genes that share compounds with BRD1: view

Transcripts for BRD1 Gene

Unigene Clusters for BRD1 Gene

Bromodomain containing 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BRD1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BRD1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5:
SP6:

Relevant External Links for BRD1 Gene

GeneLoc Exon Structure for
BRD1
ECgene alternative splicing isoforms for
BRD1

Expression for BRD1 Gene

mRNA expression in normal human tissues for BRD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for BRD1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (23.1), Platelet (17.8), and CD8 Tcells (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BRD1 Gene

SOURCE GeneReport for Unigene cluster for BRD1 Gene Hs.127950

mRNA Expression by UniProt/SwissProt for BRD1 Gene

O95696-BRD1_HUMAN
Tissue specificity: Highly expressed in testis
genes like me logo Genes that share expressions with BRD1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for BRD1 Gene

Orthologs for BRD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BRD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BRD1 35
  • 85.49 (n)
  • 90.62 (a)
BRD1 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BRD1 35
  • 89.04 (n)
  • 93.95 (a)
BRD1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Brd1 35
  • 88.56 (n)
  • 95.27 (a)
Brd1 16
Brd1 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BRD1 35
  • 98.93 (n)
  • 99.15 (a)
BRD1 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Brd1 35
  • 88.56 (n)
  • 95.27 (a)
oppossum
(Monodelphis domestica)
Mammalia BRD1 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BRD1 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves BRD1 35
  • 75.33 (n)
  • 87.05 (a)
BRD1 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BRD1 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia brd1 35
  • 69.31 (n)
  • 79.45 (a)
Str.2833 35
zebrafish
(Danio rerio)
Actinopterygii brd1a 35
  • 62.35 (n)
  • 63.65 (a)
brd1a 36
  • 57 (a)
OneToMany
brd1b 36
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1845 37
  • 45 (a)
Br140 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lin-49 37
  • 29 (a)
lin-49 36
  • 21 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NTO1 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for BRD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BRD1 Gene

ENSEMBL:
Gene Tree for BRD1 (if available)
TreeFam:
Gene Tree for BRD1 (if available)

Paralogs for BRD1 Gene

Paralogs for BRD1 Gene

genes like me logo Genes that share paralogs with BRD1: view

Variants for BRD1 Gene

Sequence variations from dbSNP and Humsavar for BRD1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs4468 -- 49,774,004(+) CGGCC(C/T)GGGGA utr-variant-3-prime, nc-transcript-variant
rs4469 -- 49,777,289(+) CAGAC(A/G)GGCCT intron-variant
rs138821 -- 49,772,916(+) CGGTG(A/G)GTGAT downstream-variant-500B
rs138822 -- 49,774,616(+) GGATA(C/G)GGGGA intron-variant
rs138823 -- 49,775,509(+) TGCTC(A/G)CCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BRD1 Gene

Variant ID Type Subtype PubMed ID
dgv5046n71 CNV Loss 21882294
nsv915495 CNV Loss 21882294
nsv834235 CNV Loss 17160897
dgv5049n71 CNV Loss 21882294
nsv915502 CNV Loss 21882294
nsv3667 CNV Insertion 18451855
esv2724705 CNV Deletion 23290073
nsv829328 CNV Gain 20364138
dgv265n21 CNV Loss 19592680
esv2724707 CNV Deletion 23290073
esv2724708 CNV Deletion 23290073
nsv915505 CNV Loss 21882294

Relevant External Links for BRD1 Gene

HapMap Linkage Disequilibrium report
BRD1
Human Gene Mutation Database (HGMD)
BRD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRD1 Gene

Disorders for BRD1 Gene

Relevant External Links for BRD1

Genetic Association Database (GAD)
BRD1
Human Genome Epidemiology (HuGE) Navigator
BRD1

No disorders were found for BRD1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for BRD1 Gene

Publications for BRD1 Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3 4
  2. The cloning, mapping and expression of a novel gene, BRL, related to the AF10 leukaemia gene. (PMID: 10602503) McCullagh P. … Young B.D. (Oncogene 1999) 2 3 4
  3. Association study of bromodomain-containing 1 gene with schizophrenia in Japanese population. (PMID: 19908236) Kushima I. … Ozaki N. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 23 48
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  5. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. (PMID: 16387653) Doyon Y. … Cote J. (Mol. Cell 2006) 3 4

Products for BRD1 Gene

Sources for BRD1 Gene

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