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BRD1 Gene

protein-coding   GIFtS: 63
GCID: GC22M050166

Bromodomain Containing 1

(Previous name: bromodomain-containing 1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Bromodomain Containing 11 2     BR140-like1
BRL2 3 5     Bromodomain-Containing 11
Bromodomain And PHD Finger-Containing Protein 22 3     BRPF12
BRPF22 3     Bromodomain-Containing Protein 12
BR140-Like Protein2 3     

External Ids:    HGNC: 11021   Entrez Gene: 237742   Ensembl: ENSG000001004257   OMIM: 6045895   UniProtKB: O956963   

Export aliases for BRD1 gene to outside databases

Previous GC identifers: GC22M046756 GC22M048386 GC22M048487 GC22M048552 GC22M033113


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BRD1 Gene:
This gene encodes a protein of unknown function. The protein contains a bromodomain, a sequence motif often found
in transcriptional coactivators, and localizes to the nucleus in testis and several other cell types. (provided
by RefSeq, Jul 2008)

GeneCards Summary for BRD1 Gene:
BRD1 (bromodomain containing 1) is a protein-coding gene. Diseases associated with BRD1 include spotted fever, and schizophrenia. GO annotations related to this gene include histone binding. An important paralog of this gene is JADE2.

UniProtKB/Swiss-Prot: BRD1_HUMAN, O95696
Function: Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BRD1 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   GR   oct-B3   oct-B2   POU2F2   POU2F2C   POU2F1   POU2F1a   GR-alpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for BRD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BRD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.33   Ensembl cytogenetic band:  22q13.33   HGNC cytogenetic band: 22q13.33

BRD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRD1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M050166:  view genomic region     (about GC identifiers)

Start:
50,166,931 bp from pter      End:
50,221,160 bp from pter
Size:
54,230 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BRD1_HUMAN, O95696 (See protein sequence)
Recommended Name: Bromodomain-containing protein 1  
Size: 1058 amino acids; 119520 Da
Subunit: Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1,
BRD1/BRPF2 and BRPF3. Interacts (via PHD-type zinc finger domain) with unmodified histone H3. Interacts (via PWWP
domain) with dimethylated and trimethylated 'Lys-79' on histone H3
5 PDB 3D structures from and Proteopedia for BRD1:
2KU3 (3D)        2L43 (3D)        2LQ6 (3D)        3LYI (3D)        3RCW (3D)    
Secondary accessions: A6ZJA4
Alternative splicing: 2 isoforms:  O95696-1   O95696-2   (Contains a phosphoserine at position 906)

Explore the universe of human proteins at neXtProt for BRD1: NX_O95696

Explore proteomics data for BRD1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys368
  • Modification sites at PhosphoSitePlus

  • See BRD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055392.1  
    ENSEMBL proteins: 
     ENSP00000388027   ENSP00000216267   ENSP00000384076   ENSP00000385858   ENSP00000437514  
     ENSP00000345886   ENSP00000410042  
    Reactome Protein details: O95696

    BRD1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for BRD1
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    Novus Biologicals BRD1 Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BRD1

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    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. CLIAs for BRD1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 9):
     IPR001965 Znf_PHD
     IPR013083 Znf_RING/FYVE/PHD
     IPR019786 Zinc_finger_PHD-type_CS
     IPR018359 Bromodomain_CS
     IPR001487 Bromodomain

    Graphical View of Domain Structure for InterPro Entry O95696

    ProtoNet protein and cluster: O95696

    3 Blocks protein domains:
    IPB000313 PWWP domain
    IPB001487 Bromodomain signature
    IPB001965 Zn-finger-like


    UniProtKB/Swiss-Prot: BRD1_HUMAN, O95696
    Similarity: Contains 1 bromo domain
    Similarity: Contains 1 PHD-type zinc finger
    Similarity: Contains 1 PWWP domain


    BRD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BRD1_HUMAN, O95696
    Function: Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0042393histone binding IDA--
         
    BRD1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for BRD1:
     Increased cell death HMECs cel 

         9 MGI mutant phenotypes (inferred from 1 allele(MGI details for Brd1):
     cellular  embryogenesis  growth/size/body  hematopoietic system  integument 
     liver/biliary system  mortality/aging  nervous system  vision/eye 

    BRD1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Brd1tm1Hko for BRD1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BRD1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BRD1

    miRNA
    Products:
        
    miRTarBase miRNAs that target BRD1:
    hsa-mir-18a-3p (MIRT040831), hsa-mir-221-3p (MIRT024192), hsa-let-7g-5p (MIRT046561), hsa-mir-497-5p (MIRT041191), hsa-mir-186-5p (MIRT021155)

    Block miRNA regulation of human, mouse, rat BRD1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BRD1 (see all 38):
    hsa-miR-142-5p hsa-miR-548j hsa-miR-548k hsa-miR-30d hsa-miR-548l hsa-miR-30a hsa-miR-155 hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidBRD1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BRD1
    Predesigned siRNA for gene silencing in human, mouse, rat BRD1

    Gene Editing
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    OriGene ORF clones in mouse, rat for BRD1
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    GenScript: all cDNA clones in your preferred vector: BRD1 (NM_014577)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRD1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRD1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BRD1_HUMAN, O95696: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS10602503
    GO:0005730NOT nucleolus IDA--
    GO:0070776MOZ/MORF histone acetyltransferase complex IDA16387653

    BRD1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BRD1 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    HATs acetylate histones0.34
    Chromatin organization0.34
    Chromatin modifying enzymes0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for BRD1
        HATs acetylate histones



    BRD1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including BRD1: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for BRD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BRD1 (O956962, 3 ENSP000002162674) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF512BQ96KM62, 3MINT-60807 I2D: score=2 
    H2AFXP161043, ENSP000003643104I2D: score=1 STRING: ENSP00000364310
    SS18L1O751773, ENSP000003330124I2D: score=1 STRING: ENSP00000333012
    TAL1P175423, ENSP000002943394I2D: score=1 STRING: ENSP00000294339
    FEZ1Q996893, ENSP000002789194I2D: score=2 STRING: ENSP00000278919
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043966histone H3 acetylation IDA16387653

    BRD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for BRD1 (see all 11)     About this table
    CompoundAction CAS #
    (+)-JQ1BET bromodomain inhibitor[1268524-70-4]
    (-)-JQ1Inactive stereoisomer of bromodomain inhibitor (+)-JQ1[1268524-71-5]
    Bromosporinebroad spectrum inhibitor for bromodomains--
    I-BET-762inhibitor for BET proteins[1260907-17-2]
    I-BET151 (GSK1210151A)BET bromodomain inhibitor(pIC50=6.1,BRD4)[1300031-49-5]
    OTX-015new potent BRD-inhibitor [202590-98-5]
    PFI-1 (PF-6405761)selective BET inhibitor for BRD4[1403764-72-6]
    RVX-208potent BET bromodomain inhibitor for BD2[1044870-39-4]
    SGC-CBP30Potent CREBBP/EP300 bromodomain inhibitor--
    UNC1215elective MBT antagonist[1415800-43-9]

    Browse Tocris compounds for BRD1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for BRD1 gene: 
    NM_014577.1  

    Unigene Cluster for BRD1:

    Bromodomain containing 1
    Hs.127950  [show with all ESTs]
    Unigene Representative Sequence: BX640795
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000438393 ENST00000216267(uc003biv.3) ENST00000404034(uc011arg.2)
    ENST00000404760(uc011arf.2 uc021wrv.1 uc021wrw.1 uc003biu.4)
    ENST00000479985 ENST00000459821 ENST00000494833 ENST00000542442 ENST00000342989
    ENST00000457780
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate BRD1 (see all 38):
    hsa-miR-142-5p hsa-miR-548j hsa-miR-548k hsa-miR-30d hsa-miR-548l hsa-miR-30a hsa-miR-155 hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidBRD1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat BRD1
    Clone
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    GenScript: all cDNA clones in your preferred vector: BRD1 (NM_014577)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRD1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for BRD1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat BRD1
      QuantiTect SYBR Green Assays in human, mouse, rat BRD1
      QuantiFast Probe-based Assays in human, mouse, rat BRD1

    Additional mRNA sequence: 

    AB209216.1 AF005067.1 AK292428.1 AK302736.1 AK302845.1 AK304330.1 AK304776.1 AL049402.1 
    AL080149.1 BC030007.1 BC047508.1 BC131583.1 BX640795.1 CR456408.1 CR936643.1 

    12 DOTS entries:

    DT.100776199  DT.120666930  DT.106940  DT.91761955  DT.91761941  DT.120666927  DT.100776198  DT.100680641 
    DT.446314  DT.91761940  DT.92043971  DT.95288337 

    Selected AceView cDNA sequences (see all 94):

    BQ675676 BM670969 AW242320 H55108 CR456408 AF005067 AL080149 AL531747 
    AA969405 NM_014577 BM127771 AI563978 CR610367 AL049402 AI350842 BX463331 
    BI093296 BF448354 AL040577 AI697635 AA490495 BG392401 AI991928 BG680750 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BRD1 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b
    SP1:        -                 -                                         -     -                                         -               
    SP2:                          -                                         -     -                                         -               
    SP3:                          -                                                                                         -               
    SP4:                          -                                         -                                               -               
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for BRD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BRD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTTTACAC
    BRD1 Expression
    About this image


    BRD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
    BRD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BRD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.127950

    UniProtKB/Swiss-Prot: BRD1_HUMAN, O95696
    Tissue specificity: Highly expressed in testis

        Pathway & Disease-focused RT2 Profiler PCR Array including BRD1: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat BRD1
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    QuantiFast Probe-based Assays in human, mouse, rat BRD1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for BRD1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Brd11 , 5 bromodomain containing 11, 5 88.56(n)1
    95.27(a)1
      15 (44.17 cM)5
    2237701  NM_001033274.31  NP_001028446.21 
     886873005 
    chicken
    (Gallus gallus)
    Aves BRD11 bromodomain containing 1 75.33(n)
    87.05(a)
      417731  NM_001199482.1  NP_001186411.1 
    lizard
    (Anolis carolinensis)
    Reptilia BRD16
    bromodomain containing 1
    74(a)
    1 ↔ 1
    GL343277.1(125082-164651)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.28332 Transcribed sequence with moderate similarity to protein refNP_055392.1 (H.sapiens) bromodomain containing protein 1; BR140-like gene [Homo sapiens] less 77.66(n)    BX753688.1 
    zebrafish
    (Danio rerio)
    Actinopterygii brd1a1 bromodomain containing 1a 62.35(n)
    63.65(a)
      569574  XM_692971.5  XP_698063.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG18453   -- 45(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea lin-493 zinc-finger protein 29(a)   IV(8620948-8625841)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NTO16
    Subunit of the NuA3 histone acetyltransferase comp...
    26(a)
    1 → many
    XVI(631515-633761) YPR031W


    ENSEMBL Gene Tree for BRD1 (if available)
    TreeFam Gene Tree for BRD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BRD1 gene
    JADE22  BRPF12  MLLT102  PHF142  JADE32  JADE12  MLLT62  BRPF32  
    9 SIMAP similar genes for BRD1 using alignment to 6 protein entries:     BRD1_HUMAN (see all proteins):
    DKFZp586E1619    DKFZp686F0325    DKFZp434B094    BRPF3    AF10    BRPF1
    MLL/AF10 fusion    MLLT6    BRDT

    BRD1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BRD1 (see all 1320)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1890906121,2
    --50166458(+) CGCCAG/TTAGCT 1 -- ds50010--------
    rs96281281,2
    C,F,H--50166483(+) TAGCCC/ATGAGT 1 -- ds50013Minor allele frequency- A:0.00NS NA 408
    rs1145122081,2
    F--50166560(+) TGGGCG/AGTGAG 1 -- ds50011Minor allele frequency- A:0.08WA 118
    rs1388211,2
    C,F,A,H--50166564(+) CGGTGA/GGTGAT 1 -- ds500111Minor allele frequency- G:0.46EA NS WA NA CSA 662
    rs1179050611,2
    C,F--50166642(+) GCCACG/AACAGA 1 -- ds50011Minor allele frequency- A:0.02NA 120
    rs1385364621,2
    --50166711(+) TTTCTA/GTGGAG 1 -- ds50010--------
    rs1809284651,2
    --50166728(+) CAAACG/TGTGTA 1 -- ds50010--------
    rs1861178091,2
    --50166796(+) ATCAGA/GTGAAA 1 -- ds50010--------
    rs1909229531,2
    --50167020(+) AAAAAC/TAAAAA 1 -- ut310--------
    rs1440557021,2
    --50167180(+) AGGCCA/GGAGTC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for BRD1 (50166931 - 50221160 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for BRD1 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724705CNV Deletion23290073
    esv2724708CNV Deletion23290073
    esv2724707CNV Deletion23290073
    nsv3667CNV Insertion18451855
    dgv5049n71CNV Loss21882294
    nsv915505CNV Loss21882294
    nsv915495CNV Loss21882294
    nsv834235CNV Loss17160897
    dgv5046n71CNV Loss21882294
    nsv915502CNV Loss21882294

    Human Gene Mutation Database (HGMD): BRD1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BRD1
    DNA2.0 Custom Variant and Variant Library Synthesis for BRD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604589    OMIM disorders: --

    4 diseases for BRD1:    
    About MalaCards
    spotted fever    schizophrenia    cerebritis    leukemia


    BRD1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): BRD1
    Human Genome Epidemiology (HuGE) Navigator: BRD1 (4 documents)

    Export disorders for BRD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BRD1 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with BRD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The cloning, mapping and expression of a novel gene, BRL, related to the AF10 leukaemia gene. (PubMed id 10602503)1, 2, 3 McCullagh P.... Young B.D. (Oncogene 1999)
    2. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2, 3 Dunham I.... Wright H. (Nature 1999)
    3. Association study of bromodomain-containing 1 gene with schizophrenia in Japanese population. (PubMed id 19908236)1, 4, 9 Kushima I....Ozaki N. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    4. Recognition of unmodified histone H3 by the first PHD finger of bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases monocytic leukemic zinc-finger protein (MOZ) and MOZ-related factor (MORF). (PubMed id 21880731)1, 2 Qin S.... Shi Y. (J. Biol. Chem. 2011)
    5. Structural and histone binding ability characterizations of human PWWP domains. (PubMed id 21720545)1, 2 Wu H.... Min J. (PLoS ONE 2011)
    6. Support of association between BRD1 and both schizophrenia and bipolar affective disorder. (PubMed id 19693800)1, 4 Nyegaard M....rglum A.D. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. (PubMed id 16387653)1, 2 Doyon Y.... Cote J. (Mol. Cell 2006)
    9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    10. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23774 HGNC: 1102 AceView: BRD1 Ensembl:ENSG00000100425 euGenes: HUgn23774
    ECgene: BRD1 H-InvDB: BRD1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BRD1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BRD1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BRD1 gene:
    Search GeneIP for patents involving BRD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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