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Aliases for BRD1 Gene

Aliases for BRD1 Gene

  • Bromodomain Containing 1 2 3 5
  • Bromodomain And PHD Finger-Containing Protein 2 3 4
  • BR140-Like Protein 3 4
  • BRPF2 3 4
  • BRL 3 4
  • Bromodomain-Containing Protein 1 3
  • Bromodomain-Containing 1 2
  • BR140-Like 2
  • BRPF1 3

External Ids for BRD1 Gene

Previous GeneCards Identifiers for BRD1 Gene

  • GC22M046756
  • GC22M048386
  • GC22M048487
  • GC22M048552
  • GC22M050166
  • GC22M033113

Summaries for BRD1 Gene

Entrez Gene Summary for BRD1 Gene

  • This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4, thereby potentially playing a role in gene activation. Variation in this gene is associated with schozophrenia and bipolar disorder in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for BRD1 Gene

BRD1 (Bromodomain Containing 1) is a Protein Coding gene. Among its related pathways are Chromatin organization and Gene Expression. GO annotations related to this gene include histone binding. An important paralog of this gene is BRPF3.

UniProtKB/Swiss-Prot for BRD1 Gene

  • Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.

Tocris Summary for BRD1 Gene

  • Bromodomains (BRDs) are epigenetic reader domains that selectively recognize acetylated lysine residues on the tails of histone proteins, and are the only known protein modules that can target acetylated lysine residues.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRD1 Gene

Genomics for BRD1 Gene

Regulatory Elements for BRD1 Gene

Enhancers for BRD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F049784 0.6 ENCODE 12.8 +42.2 42151 1.2 KLF1 NR2F1 BHLHE40 NR2F6 MYC NR2C2 EGR2 ZKSCAN1 BRD1 ENSG00000229409 ZBED4 ALG12 CRELD2 LOC105377205 ENSG00000235111 GC22M049780 GC22M049777
GH22F049786 0.7 ENCODE 12.8 +41.4 41361 0.2 KLF1 ARNT TAL1 NR2F1 BHLHE40 YBX1 ZKSCAN1 ARID1B IKZF1 NR2F6 BRD1 ENSG00000229409 ZBED4 GC22M049780 GC22M049795 PIR31802
GH22F049788 1.1 Ensembl ENCODE 12.8 +38.3 38316 2.4 ELF3 DRAP1 SAP130 ARID4B CEBPG ZNF48 GLIS2 NR2F6 THAP11 ZNF263 BRD1 ENSG00000229409 ZBED4 LOC105377205 CRELD2 GC22M049780 GC22M049795 PIR31802
GH22F050188 1.1 FANTOM5 ENCODE 9.9 -363.5 -363532 5.6 HDGF PKNOX1 ARID4B SIN3A YBX1 ZNF2 ZNF143 ZNF263 MCM3 SP3 TUBGCP6 MAPK12 ALG12 ZBED4 ENSG00000272836 HDAC10 LOC105373095 LOC101928719 MAPK11 PLXNB2
GH22F050183 1.2 FANTOM5 ENCODE 6.5 -358.3 -358276 3.9 ATF1 ARID4B DMAP1 ZNF48 ZNF2 YY1 ZNF121 GTF3C2 GLIS2 ZNF143 ALG12 TRABD LOC105373095 SELENOO ZBED4 LOC101928719 ENSG00000273192 ENSG00000272836 LOC100420885 PANX2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around BRD1 on UCSC Golden Path with GeneCards custom track

Promoters for BRD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for BRD1 Gene

49,773,278 bp from pter
49,827,548 bp from pter
54,271 bases
Minus strand

Genomic View for BRD1 Gene

Genes around BRD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRD1 Gene

Proteins for BRD1 Gene

  • Protein details for BRD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Bromodomain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • A6ZJA4

    Protein attributes for BRD1 Gene

    1058 amino acids
    Molecular mass:
    119520 Da
    Quaternary structure:
    • Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. Interacts (via PHD-type zinc finger domain) with unmodified histone H3. Interacts (via PWWP domain) with dimethylated and trimethylated Lys-79 on histone H3.

    Three dimensional structures from OCA and Proteopedia for BRD1 Gene

    Alternative splice isoforms for BRD1 Gene


neXtProt entry for BRD1 Gene

Post-translational modifications for BRD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for BRD1

No data available for DME Specific Peptides for BRD1 Gene

Domains & Families for BRD1 Gene

Gene Families for BRD1 Gene

Suggested Antigen Peptide Sequences for BRD1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 bromo domain.
  • Contains 1 C2HC pre-PHD-type zinc finger.
  • Contains 1 bromo domain.
  • Contains 1 PWWP domain.
  • Contains 1 C2HC pre-PHD-type zinc finger.
  • Contains 2 PHD-type zinc fingers.
genes like me logo Genes that share domains with BRD1: view

Function for BRD1 Gene

Molecular function for BRD1 Gene

UniProtKB/Swiss-Prot Function:
Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.

Gene Ontology (GO) - Molecular Function for BRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0042393 histone binding IDA 21880731
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with BRD1: view
genes like me logo Genes that share phenotypes with BRD1: view

Animal Models for BRD1 Gene

MGI Knock Outs for BRD1:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BRD1 Gene

Localization for BRD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRD1 Gene

Subcellular locations from

Jensen Localization Image for BRD1 Gene COMPARTMENTS Subcellular localization image for BRD1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for BRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10602503
GO:0005654 nucleoplasm IDA --
GO:0030425 dendrite IEA --
GO:0043204 perikaryon IEA --
GO:0070776 MOZ/MORF histone acetyltransferase complex IDA 16387653
genes like me logo Genes that share ontologies with BRD1: view

Pathways & Interactions for BRD1 Gene

genes like me logo Genes that share pathways with BRD1: view

Gene Ontology (GO) - Biological Process for BRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016569 covalent chromatin modification IEA --
GO:0035902 response to immobilization stress IEA --
GO:0043966 histone H3 acetylation IDA 16387653
GO:0051602 response to electrical stimulus IEA --
genes like me logo Genes that share ontologies with BRD1: view

No data available for SIGNOR curated interactions for BRD1 Gene

Drugs & Compounds for BRD1 Gene

(10) Drugs for BRD1 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Propionyl-CoA Experimental Pharma 0
CPI-203 Pharma BET bromodomain inhibitor 0
I-BET151 (GSK1210151A) Pharma Selective BET inhibitor 0
I-BET-762 Pharma BET inhibitor,highly potent 0
MS436 Pharma BRD4 inhibitor 0

(31) Additional Compounds for BRD1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A

(9) ApexBio Compounds for BRD1 Gene

Compound Action Cas Number
CPI-203 BET bromodomain inhibitor 1446144-04-2
I-BET151 (GSK1210151A) Selective BET inhibitor 1300031-49-5
I-BET-762 BET inhibitor,highly potent 1260907-17-2
MS436 BRD4 inhibitor 1395084-25-9
OF-1 BRPF1B and BRPF2 bromodomain inhibitor 919973-83-4
PFI-1 (PF-6405761) BET inhibitor 1403764-72-6
RVX-208 Potent BET bromodomain inhibitor 1044870-39-4
UNC1215 Chemical probe for the methyllysine (Kme) 1415800-43-9
UNC669 L3MBTL antagonist,potent and selective 1314241-44-5
genes like me logo Genes that share compounds with BRD1: view

Transcripts for BRD1 Gene

Unigene Clusters for BRD1 Gene

Bromodomain containing 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BRD1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: - - -

Relevant External Links for BRD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BRD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for BRD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for BRD1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (23.1), Platelet (17.8), and CD8 Tcells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BRD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of BRD1 Gene:


SOURCE GeneReport for Unigene cluster for BRD1 Gene:


mRNA Expression by UniProt/SwissProt for BRD1 Gene:

Tissue specificity: Highly expressed in testis.
genes like me logo Genes that share expression patterns with BRD1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for BRD1 Gene

Orthologs for BRD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for BRD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BRD1 34 35
  • 98.93 (n)
(Canis familiaris)
Mammalia BRD1 34 35
  • 89.04 (n)
(Mus musculus)
Mammalia Brd1 34 16 35
  • 88.56 (n)
(Rattus norvegicus)
Mammalia Brd1 34
  • 88.56 (n)
(Bos Taurus)
Mammalia BRD1 34 35
  • 85.49 (n)
(Ornithorhynchus anatinus)
Mammalia BRD1 35
  • 80 (a)
(Monodelphis domestica)
Mammalia BRD1 35
  • 77 (a)
(Gallus gallus)
Aves BRD1 34 35
  • 75.33 (n)
(Anolis carolinensis)
Reptilia BRD1 35
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia brd1 34
  • 69.31 (n)
Str.2833 34
(Danio rerio)
Actinopterygii brd1a 34 35
  • 62.35 (n)
brd1b 35
  • 53 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1845 36
  • 45 (a)
Br140 35
  • 31 (a)
(Caenorhabditis elegans)
Secernentea lin-49 36 35
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NTO1 35
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
Species where no ortholog for BRD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BRD1 Gene

Gene Tree for BRD1 (if available)
Gene Tree for BRD1 (if available)

Paralogs for BRD1 Gene

Paralogs for BRD1 Gene

genes like me logo Genes that share paralogs with BRD1: view

Variants for BRD1 Gene

Sequence variations from dbSNP and Humsavar for BRD1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs10427831 -- 49,808,476(+) tcaaa(C/T)tcatg intron-variant
rs10427974 -- 49,783,317(+) TCCAC(C/T)GGGCA intron-variant, nc-transcript-variant, utr-variant-3-prime
rs111322415 -- 49,799,741(+) CAGGC(C/T)GCCAG intron-variant
rs111406899 -- 49,823,151(+) GGAGG(A/C/T)GTGTG nc-transcript-variant, reference, synonymous-codon, utr-variant-5-prime
rs111422260 -- 49,783,028(+) CAGAC(C/G)CAAGG intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for BRD1 Gene

Variant ID Type Subtype PubMed ID
dgv265n21 CNV loss 19592680
esv2724705 CNV deletion 23290073
esv2724707 CNV deletion 23290073
esv2724708 CNV deletion 23290073
esv3648071 CNV loss 21293372
esv3648072 CNV loss 21293372
nsv3667 CNV insertion 18451855
nsv829328 CNV gain 20364138
nsv834235 CNV loss 17160897
nsv955194 CNV deletion 24416366

Variation tolerance for BRD1 Gene

Residual Variation Intolerance Score: 1.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.75; 66.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BRD1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRD1 Gene

Disorders for BRD1 Gene

Relevant External Links for BRD1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for BRD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BRD1 Gene

Publications for BRD1 Gene

  1. Association study of bromodomain-containing 1 gene with schizophrenia in Japanese population. (PMID: 19908236) Kushima I. … Ozaki N. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 22 46 64
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3 4 64
  3. The cloning, mapping and expression of a novel gene, BRL, related to the AF10 leukaemia gene. (PMID: 10602503) McCullagh P. … Young B.D. (Oncogene 1999) 2 3 4 64
  4. Histone recognition and large-scale structural analysis of the human bromodomain family. (PMID: 22464331) Filippakopoulos P. … Knapp S. (Cell 2012) 3 4 64
  5. Structural and histone binding ability characterizations of human PWWP domains. (PMID: 21720545) Wu H. … Min J. (PLoS ONE 2011) 3 4 64

Products for BRD1 Gene

Sources for BRD1 Gene

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