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Aliases for BRCA2 Gene

Aliases for BRCA2 Gene

  • Breast Cancer 2 2 3 5
  • Fanconi Anemia Group D1 Protein 3 4
  • Breast Cancer 2, Early Onset 2 3
  • FANCD1 3 4
  • FACD 3 4
  • Breast And Ovarian Cancer Susceptibility Gene, Early Onset 3
  • Breast And Ovarian Cancer Susceptibility Protein 2 3
  • BRCA1/BRCA2-Containing Complex, Subunit 2 3
  • Fanconi Anemia, Complementation Group D1 2
  • Breast Cancer 2 Tumor Suppressor 3
  • BRCA1/BRCA2-Containing Complex 2
  • Mutant BRCA2 3
  • Subunit 2 2
  • BROVCA2 3
  • XRCC11 3
  • BRCC2 3
  • PNCA2 3
  • FANCD 3
  • FAD1 3
  • GLM3 3
  • FAD 3

External Ids for BRCA2 Gene

Previous HGNC Symbols for BRCA2 Gene

  • FANCD1
  • FACD
  • FANCD

Previous GeneCards Identifiers for BRCA2 Gene

  • GC13P030875
  • GC13P026876
  • GC13P031826
  • GC13P030687
  • GC13P031787
  • GC13P032889
  • GC13P013701

Summaries for BRCA2 Gene

Entrez Gene Summary for BRCA2 Gene

  • Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008]

GeneCards Summary for BRCA2 Gene

BRCA2 (Breast Cancer 2) is a Protein Coding gene. Diseases associated with BRCA2 include breast cancer and fanconi anemia, complementation group d1. Among its related pathways are Cell Cycle, Mitotic and Integrated Pancreatic Cancer Pathway. GO annotations related to this gene include protease binding and histone acetyltransferase activity.

UniProtKB/Swiss-Prot for BRCA2 Gene

  • Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SHFM1/DSS1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180).

Gene Wiki entry for BRCA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRCA2 Gene

Genomics for BRCA2 Gene

Regulatory Elements for BRCA2 Gene

Promoters for BRCA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BRCA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for BRCA2 Gene

Chromosome:
13
Start:
32,314,862 bp from pter
End:
32,400,266 bp from pter
Size:
85,405 bases
Orientation:
Plus strand

Genomic View for BRCA2 Gene

Genes around BRCA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRCA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRCA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRCA2 Gene

Proteins for BRCA2 Gene

  • Protein details for BRCA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51587-BRCA2_HUMAN
    Recommended name:
    Breast cancer type 2 susceptibility protein
    Protein Accession:
    P51587
    Secondary Accessions:
    • O00183
    • O15008
    • Q13879
    • Q5TBJ7

    Protein attributes for BRCA2 Gene

    Size:
    3418 amino acids
    Molecular mass:
    384202 Da
    Quaternary structure:
    • Monomer and dimer. Interacts with RAD51; regulates RAD51 recruitment and function at sites of DNA repair. Interacts with WDR16, USP11, DMC1, ROCK2 and NPM1. Interacts with SHFM1/DSS1; the interaction masks a nuclear export signal in BRCA2. Interacts with both nonubiquitinated and monoubiquitinated FANCD2; this complex also includes XRCC3 and phosphorylated FANCG. Part of a BRCA complex containing BRCA1, BRCA2 and PALB2. Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3. Interacts with BRCA1 only in the presence of PALB2 which serves as the bridging protein. Interacts with POLH; the interaction is direct. Interacts with the TREX-2 complex subunits PCID2 and SHFM1/DSS1 (PubMed:24896180, PubMed:21719596).

    Three dimensional structures from OCA and Proteopedia for BRCA2 Gene

neXtProt entry for BRCA2 Gene

Proteomics data for BRCA2 Gene at MOPED

Post-translational modifications for BRCA2 Gene

  • Phosphorylated by ATM upon irradiation-induced DNA damage. Phosphorylation by CHEK1 and CHEK2 regulates interaction with RAD51. Phosphorylation at Ser-3291 by CDK1 and CDK2 is low in S phase when recombination is active, but increases as cells progress towards mitosis; this phosphorylation prevents homologous recombination-dependent repair during S phase and G2 by inhibiting RAD51 binding.
  • Ubiquitinated in the absence of DNA damage; this does not lead to proteasomal degradation. In contrast, ubiquitination in response to DNA damage leads to proteasomal degradation.
  • Ubiquitination at Lys 1872 and Lys 2077
  • Modification sites at PhosphoSitePlus

Other Protein References for BRCA2 Gene

Antibody Products

No data available for DME Specific Peptides for BRCA2 Gene

Domains & Families for BRCA2 Gene

Gene Families for BRCA2 Gene

Protein Domains for BRCA2 Gene

Graphical View of Domain Structure for InterPro Entry

P51587

UniProtKB/Swiss-Prot:

BRCA2_HUMAN :
  • Contains 8 BRCA2 repeats.
Similarity:
  • Contains 8 BRCA2 repeats.
genes like me logo Genes that share domains with BRCA2: view

Function for BRCA2 Gene

Molecular function for BRCA2 Gene

GENATLAS Biochemistry:
BRCA2 homolog to C elegans T07E3 uncharacterized gene,expressed in many tissues and most abundant in the S phase,complexing and interacting with phosphorylated BRCA1,RAD51 and RAD52 for cell cycle control and DNA repair through homologous recombination,also involved in embryonic cellular proliferation
UniProtKB/Swiss-Prot Function:
Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SHFM1/DSS1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability. Silencing of BRCA2 promotes R-loop accumulation at actively transcribed genes in replicating and non-replicating cells, suggesting that BRCA2 mediates the control of R-loop associated genomic instability, independently of its known role in homologous recombination (PubMed:24896180).

Gene Ontology (GO) - Molecular Function for BRCA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003697 single-stranded DNA binding IDA 20729832
GO:0043015 gamma-tubulin binding IPI 17286961
genes like me logo Genes that share ontologies with BRCA2: view
genes like me logo Genes that share phenotypes with BRCA2: view

Human Phenotype Ontology for BRCA2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for BRCA2 Gene

MGI Knock Outs for BRCA2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for BRCA2 Gene

Localization for BRCA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRCA2 Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BRCA2 Gene COMPARTMENTS Subcellular localization image for BRCA2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4

No data available for Gene Ontology (GO) - Cellular Components for BRCA2 Gene

Pathways & Interactions for BRCA2 Gene

genes like me logo Genes that share pathways with BRCA2: view

Interacting Proteins for BRCA2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000369497%0d%0a9606.ENSP00000372088%0d%0a9606.ENSP00000261584%0d%0a9606.ENSP00000248566%0d%0a9606.ENSP00000248566%0d%0a9606.ENSP00000418960%0d%0a
Selected Interacting proteins: P51587-BRCA2_HUMAN ENSP00000369497 for BRCA2 Gene via I2D MINT UniProtKB STRING

Symbol External ID(s) Details
RAD51
PALB2
DMC1
SHFM1
PDS5B

SIGNOR curated interactions for BRCA2 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for BRCA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000722 telomere maintenance via recombination IEA --
GO:0000724 double-strand break repair via homologous recombination IEA,IMP 21719596
GO:0000731 DNA synthesis involved in DNA repair TAS --
GO:0000732 strand displacement TAS --
GO:0000910 cytokinesis IDA 17286961
genes like me logo Genes that share ontologies with BRCA2: view

Drugs & Compounds for BRCA2 Gene

(52) Drugs for BRCA2 Gene - From: Novoseek, DGIdb, and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum 2540
Paclitaxel Approved Pharma Tubulin and Bcl2 inhibitor, Taxanes 2621
Carboplatin Approved Pharma Antitumor agent that forms platinum-DNA adducts., Platinum 1885
Pancrelipase Approved Pharma 880
Secretin Approved, Investigational Pharma Full agonist, Agonist 29

(21) Additional Compounds for BRCA2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BRCA2: view

Transcripts for BRCA2 Gene

Unigene Clusters for BRCA2 Gene

Breast cancer 2, early onset:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BRCA2 Gene

No ASD Table

Relevant External Links for BRCA2 Gene

GeneLoc Exon Structure for
BRCA2
ECgene alternative splicing isoforms for
BRCA2

Expression for BRCA2 Gene

mRNA expression in normal human tissues for BRCA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BRCA2 Gene

This gene is overexpressed in Testis (x4.6).

Protein differential expression in normal tissues from HIPED for BRCA2 Gene

This gene is overexpressed in Cerebrospinal fluid (33.4), Cervix (23.0), and Heart (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BRCA2 Gene



SOURCE GeneReport for Unigene cluster for BRCA2 Gene Hs.34012

mRNA Expression by UniProt/SwissProt for BRCA2 Gene

P51587-BRCA2_HUMAN
Tissue specificity: Highest levels of expression in breast and thymus, with slightly lower levels in lung, ovary and spleen.
genes like me logo Genes that share expression patterns with BRCA2: view

Protein tissue co-expression partners for BRCA2 Gene

Primer Products

In Situ Assay Products

Orthologs for BRCA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for BRCA2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BRCA2 35
  • 82.64 (n)
  • 71.3 (a)
BRCA2 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BRCA2 35
  • 83.02 (n)
  • 71.27 (a)
BRCA2 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Brca2 35
  • 73.85 (n)
  • 60.49 (a)
Brca2 16
Brca2 36
  • 58 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BRCA2 35
  • 99.38 (n)
  • 99.09 (a)
BRCA2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Brca2 35
  • 72.97 (n)
  • 59.56 (a)
oppossum
(Monodelphis domestica)
Mammalia BRCA2 36
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 63 (a)
OneToMany
-- 36
  • 41 (a)
OneToMany
chicken
(Gallus gallus)
Aves BRCA2 35
  • 56.29 (n)
  • 44.41 (a)
BRCA2 36
  • 32 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BRCA2 36
  • 50 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii brca2 36
  • 27 (a)
OneToOne
Species with no ortholog for BRCA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BRCA2 Gene

ENSEMBL:
Gene Tree for BRCA2 (if available)
TreeFam:
Gene Tree for BRCA2 (if available)

Paralogs for BRCA2 Gene

genes like me logo Genes that share paralogs with BRCA2: view

No data available for Paralogs for BRCA2 Gene

Variants for BRCA2 Gene

Sequence variations from dbSNP and Humsavar for BRCA2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
VAR_005085 Breast cancer (BC)
VAR_005086 Breast cancer (BC)
rs28897701 - 32,319,232(+) AGCTG(C/G)CTTCA reference, missense
VAR_005088 Breast cancer (BC)
VAR_005089 Breast cancer (BC)

Structural Variations from Database of Genomic Variants (DGV) for BRCA2 Gene

Variant ID Type Subtype PubMed ID
nsv832576 CNV Gain 17160897
nsv819799 CNV Gain 19587683
esv271116 CNV Insertion 20981092

Variation tolerance for BRCA2 Gene

Residual Variation Intolerance Score: 40.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.51; 71.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BRCA2 Gene

HapMap Linkage Disequilibrium report
BRCA2
Human Gene Mutation Database (HGMD)
BRCA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRCA2 Gene

Disorders for BRCA2 Gene

MalaCards: The human disease database

(75) MalaCards diseases for BRCA2 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
fanconi anemia, complementation group d1
  • fanconi anemia complementation group d1
breast-ovarian cancer, familial, 2
  • brovca2
pancreatic cancer 2
  • pnca2
glioblastoma 3
  • glioma 3
- elite association - COSMIC cancer census association via MalaCards
Search BRCA2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

BRCA2_HUMAN
  • Breast cancer (BC) [MIM:114480]: A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case. {ECO:0000269 PubMed:10399947, ECO:0000269 PubMed:10978364, ECO:0000269 PubMed:11139248, ECO:0000269 PubMed:11241844, ECO:0000269 PubMed:11948477, ECO:0000269 PubMed:12145750, ECO:0000269 PubMed:12373604, ECO:0000269 PubMed:12442274, ECO:0000269 PubMed:12442275, ECO:0000269 PubMed:12938098, ECO:0000269 PubMed:14722926, ECO:0000269 PubMed:15026808, ECO:0000269 PubMed:15172753, ECO:0000269 PubMed:15365993, ECO:0000269 PubMed:8640237, ECO:0000269 PubMed:9150152, ECO:0000269 PubMed:9609997, ECO:0000269 PubMed:9654203, ECO:0000269 PubMed:9971877}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Breast-ovarian cancer, familial, 2 (BROVCA2) [MIM:612555]: A condition associated with familial predisposition to cancer of the breast and ovaries. Characteristic features in affected families are an early age of onset of breast cancer (often before age 50), increased chance of bilateral cancers (cancer that develop in both breasts, or both ovaries, independently), frequent occurrence of breast cancer among men, increased incidence of tumors of other specific organs, such as the prostate. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Fanconi anemia complementation group D1 (FANCD1) [MIM:605724]: A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. {ECO:0000269 PubMed:12065746, ECO:0000269 PubMed:14670928, ECO:0000269 PubMed:16825431, ECO:0000269 PubMed:21719596}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Glioma 3 (GLM3) [MIM:613029]: Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes. {ECO:0000269 PubMed:15689453}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Pancreatic cancer 2 (PNCA2) [MIM:613347]: A malignant neoplasm of the pancreas. Tumors can arise from both the exocrine and endocrine portions of the pancreas, but 95% of them develop from the exocrine portion, including the ductal epithelium, acinar cells, connective tissue, and lymphatic tissue. {ECO:0000269 PubMed:9140390}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for BRCA2 Gene

familial breast carcinoma,2,with a high incidence of male breast cancer,sporadic or familial,and of laryngeal,prostate,ovarian carcinomas (see TSG13D)

Relevant External Links for BRCA2

Genetic Association Database (GAD)
BRCA2
Human Genome Epidemiology (HuGE) Navigator
BRCA2
Tumor Gene Database (TGDB):
BRCA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BRCA2
genes like me logo Genes that share disorders with BRCA2: view

Publications for BRCA2 Gene

  1. Novel germline mutations in the BRCA1 and BRCA2 genes in Indian breast and breast-ovarian cancer families. (PMID: 14722926) Valarmathi M.T. … Das S.N. (Hum. Mutat. 2004) 3 4 48 67
  2. Use of DNA-damaging agents and RNA pooling to assess expression profiles associated with BRCA1 and BRCA2 mutation status in familial breast cancer patients. (PMID: 20174566) Walker L.C. … Spurdle A.B. (PLoS Genet. 2010) 3 23
  3. Cell cycle-dependent regulation of the bi-directional overlapping promoter of human BRCA2/ZAR2 genes in breast cancer cells. (PMID: 20202217) Misra S. … Chaudhuri G. (Mol. Cancer 2010) 3 23
  4. Mapping the physical and functional interactions between the tumor suppressors p53 and BRCA2. (PMID: 20421506) Rajagopalan S. … Fersht A.R. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 23
  5. BRCA1 and BRCA2 mutations in women of different ethnicities undergoing testing for hereditary breast-ovarian cancer. (PMID: 19241424) Hall M.J. … Noll W.W. (Cancer 2009) 3 23

Products for BRCA2 Gene

Sources for BRCA2 Gene

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