BRCA1 Gene

Aliases &
Descriptions
for BRCA1

Previous GC identifers: GC17P062255 GC17M043361 GC17M041105 GC17M041569

Summaries
for BRCA1

Gene Wiki entry for BRCA1

Genomic Location
for BRCA1

Proteins
for BRCA1

PDB structures from and Proteopedia :

1JM7 (3D)    1JNX (3D)    1N5O (3D)    1OQA (3D)    1T15 (3D)    1T29 (3D)    1T2U (3D)    1T2V (3D)    

1Y98 (3D)    2ING (3D)    3COJ (3D)    

Post-translational modifications:

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (BRCA1)
	Human Recombinant Proteins from Abnova (BRCA1)

5/8 Gene Ontology (GO) cellular component terms (links to tree view) (see all 8 ):

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of BRCA1
	Sigma-Aldrich Antibodies for BRCA1
	R&D Systems Antibodies for BRCA1
	Cell Signaling Technology (CST) Antibodies for BRCA1
	Antibodies from Abcam (BRCA1), each with their AbpromiseSM
	Monoclonal and Polyclonal Antibodies from Abnova (BRCA1)
	Novus Biologicals Antibodies for BRCA1

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of BRCA1
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for BRCA1

5/6 InterPro domains/families (see all 6 ):

IPR017907 Znf_RING_CS  IPR001841 Znf_RING  IPR002378 Brst_cancerI  IPR011364 BRCA1  IPR018957 Znf_C3HC4_RING-type    GeneDecks  BRCA1 for the domains selected above   About GeneDecksing

Graphical View of Domain Structure for InterPro Entry P38398

ProtoNet protein and cluster: P38398

Gene Function
for BRCA1

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BRCA1)
		Millipore RNAi Products for the Analysis of BRCA1 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (BRCA1)

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

15/17 MGI mutant phenotypes (inferred from 16 alleles) (MGI details for Brca1) (see all 17 ):

5/9 Gene Ontology (GO) molecular function terms (links to tree view) (see all 9 ):

Pathways & Interactions
for BRCA1

5 Invitrogen iPath™ Online BioAtlas - Pathways for BRCA1 (Maps provided by GeneGo):

p53-dependent apoptosis  Cell Cycle Regulation by Brca1  VEGF signaling and activation  Role of Brca1 and Brca2 in DNA repair  Estrogen receptor signaling pathway    GeneDecks  BRCA1 for the pathways selected above   About GeneDecksing

5/10 Millipore Pathways for BRCA1 (see all 10 )

DNA damage ATM/ATR regulation of G1/S checkpoint  Development VEGF signaling and activation  Meiosis  Cell cycle Regulation of G1/S transition (part 1)  DNA damage DNA-damage-induced responses    GeneDecks  BRCA1 for the pathways selected above   About GeneDecksing

5/8 Sigma-Aldrich "Your Favorite Gene" Pathways for  BRCA1  (Your Favorite Gene powered by Ingenuity)

p53 Signaling  Protein Ubiquitination Pathway  Cell Cycle: G2/M DNA Damage Checkpoint Regulation  Role of CHK Proteins in Cell Cycle Checkpoint Control  Molecular Mechanisms of Cancer    GeneDecks  BRCA1 for the pathways selected above   About GeneDecksing

1 Cell Signaling Technology (CST) Pathway for BRCA1: 

Cell Cycle Control: G2/M DNA Damage Checkpoint    GeneDecks  BRCA1 for the pathways selected above   About GeneDecksing

1 Kegg Pathway  (Kegg details for BRCA1):

hsa04120 Ubiquitin mediated proteolysis    GeneDecks  BRCA1 for the pathways selected above   About GeneDecksing

 Gene Network Central^TM Interacting Genes and Proteins Network for  BRCA1 


5/265 Interacting proteins for BRCA1 (ENSP00000350283³ P38398^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 265 )

5/23 Gene Ontology (GO) biological process terms (links to tree view) (see all 23 ):

Drugs & Compounds
for BRCA1

Transcripts
for BRCA1

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BRCA1)
		Millipore RNAi Products for the Analysis of BRCA1 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (BRCA1)

Applied Biosystems Silencer® siRNAs: 

REFSEQ mRNAs for BRCA1 gene (11 alternative transcripts): 

Applied Biosystems TaqMan ® Gene Expression Assays: 

Expression
for BRCA1

BRCA1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for BRCA1

¹ / ² / ³

8 probe-sets matching BRCA1 gene

	Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
			# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
	604_at2, 3	U95-A	1	1.00	1.00	0.85	1.09	L78833	0.20	0.25	0.23	1
	33724_at2, 3	U95-A	1	1.00	1.00	0.60	1.13	U64805	0.80	1.00	0.91	1
	1993_s_at2, 3	U95-A	2	1.00	0.97	0.76	0.65	U14680	1.00	1.00	1.00	1
	83730_at2	U95-E	1	0.38	1.00	0.40	1.22	--	--	--	--	--
	211851_x_at2, 3	U133-A	1	1.00	1.00	--	--	AF005068	0.80	1.00	0.91	1
	204531_s_at2, 3	U133-A	1	1.00	1.00	--	--	NM_007295	0.60	1.00	0.82	1
	211851_x_at2	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
	204531_s_at2	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.194143

Expression variation in blood from EXPOLDB for BRCA1

UniProtKB/Swiss-Prot: BRCA1_HUMAN, P38398

Tissue specificity: Isoform 1 and isoform 3 are widely expressed. Isoform 3 is reduced or absent in

several breast and ovarian cancer cell lines

Orthologs
for BRCA1

Paralogs
for BRCA1

SNPs/Variants
for BRCA1

Disorders & Mutations
for BRCA1

UniProtKB/Swiss-Prot: BRCA1_HUMAN, P38398

10/95 Novoseek disease relationships for BRCA1 gene (see all 95 )

Medical News
for BRCA1

• Breast Cancer Susceptibility Gene Predicts Outcome and Response to Treatment in Lung Cancer
• African-American Women Less Likely to Undergo Genetic Testing for Breast or Ovarian Cancer Than White Women
• Scientists Discover Missing Link Between Rare Disease And Inherited Forms Of Breast Cancer
• Findings Offer More Complete View of Breast Cancer Gene Mutations in US Population
• U.S. Commercial Genetic Testing Does Not Detect All Cancer-Associated Mutations in the BRCA1 and BRCA2 Genes
• SGO: BRCA1 Carriers Develop Ovarian Cancer Earlier

Publications
for BRCA1

• One in 10 ovarian cancer patients carry germ line BRCA1 or BRCA2 mutations: results of a prospective study in Southern Sweden. (PubMed id 14746861)^{1, 3, 4, 6} Malander S.... Borg A. (2004)
• A comprehensive model for familial breast cancer incorporating BRCA1, BRCA2 and other genes. (PubMed id 11857015)^{1, 3, 6} Antoniou A.C....Easton D.F. (2002)
• [Mutational analysis of BRCA1 and BRCA2 genes in early-onset breast cancer patients in Shanghai] (PubMed id 16324400)^{1, 3, 6} Song C.G....Shao Z.M. (2005)
• Novel germline mutations in the BRCA1 and BRCA2 genes in Indian breast and breast-ovarian cancer families. (PubMed id 14722926)^{1, 3, 4} Valarmathi M.T.... Das S.N. (2004)
• Breast cancer risk and the DNA double-strand break end-joining capacity of nonhomologous end-joining genes are affected by BRCA1. (PubMed id 15256476)^{1, 3, 6} Bau D.T....Shen C.Y. (2004)
• Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. (PubMed id 11114888)^{1, 3, 4} Tibbetts R.S.... Abraham R.T. (2000)
• [Germline mutations in the BRCA1 and BRCA2 genes from breast cancer families in China Han people] (PubMed id 15059511)^{1, 3, 6} Zhou Y.Z....Fang F.D. (2004)
• A combined analysis of outcome following breast cancer: differences in survival based on BRCA1/BRCA2 mutation status and administration of adjuvant treatment. (PubMed id 14680495)^{1, 3, 6} Robson M.E....Foulkes W.D. (2004)
• BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function. (PubMed id 11301010)^{1, 3, 4} Cantor S.B....Livingston D.M. (2001)
• [Population genetic analysis of the association between the BRCA1 and P53 gene polymorphisms and the risk of sporadic breast cancer] (PubMed id 16161633)^{1, 3, 6} Tarasov V.A....Mel'nik V.A. (2005)
• High proportion of missense mutations of the BRCA1 and BRCA2 genes in Japanese breast cancer families. (PubMed id 9609997)^{1, 3, 4} Katagiri T.... Miki Y. (1998)
• BRCA1, BRCA2 and CHEK2 (1100 del C) germline mutations in hereditary breast and ovarian cancer families in South India. (PubMed id 14507240)^{1, 3, 6} Rajkumar T....Shanta V. (2003)
• A high proportion of mutations in the BRCA1 gene in German breast/ovarian cancer families with clustering of mutations in the 3' third of the gene. (PubMed id 9760198)^{1, 3, 4} Dong J....Royer-Pokora B. (1998)
• Comparison of BRCA1 polymorphisms, rare sequence variants and/or missense mutations in unaffected and breast/ovarian cancer populations. (PubMed id 8776600)^{1, 3, 4} Durocher F.... Simard J. (1996)
• A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. (PubMed id 7545954)^{1, 3, 4} Miki Y.... Skolnick M.H. (1994)
• BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase. (PubMed id 16326698)^{1, 3, 4} Moreau K.... Venezia N.D. (2006)
• Frequency of BRCA1 and BRCA2 mutations in unselected Ashkenazi Jewish patients with colorectal cancer. (PubMed id 14709740)^{1, 3, 6} Kirchhoff T....Offit K. (2004)
• BRCA1 and BRCA2 founder mutations and the risk of colorectal cancer. (PubMed id 14709734)^{1, 3, 6} Niell B.L....Gruber S.B. (2004)
• Association between BRCA1 mutations and ratio of female to male births in offspring of families with breast cancer, ovarian cancer, or both. (PubMed id 12928470)^{1, 3, 6} de la Hoya M....Caldes T. (2003)
• The Norwegian founder mutations in BRCA1: high penetrance confirmed in an incident cancer series and differences observed in the risk of ovarian cancer. (PubMed id 14522380)^{1, 3, 6} Heimdal K....Moller P. (2003)
• A single nucleotide polymorphism in the RAD51 gene modifies cancer risk in BRCA2 but not BRCA1 carriers. (PubMed id 11248061)^{1, 3, 6} Levy-Lahad E....Gershoni-Baruch R. (2001)
• BRCA1 R841W: a strong candidate for a common mutation with moderate phenotype. (PubMed id 8968716)^{1, 3, 4} Barker D.F.... Anton-Culver H. (1996)
• A high incidence of BRCA1 mutations in 20 breast-ovarian cancer families. (PubMed id 8554067)^{1, 3, 4} Serova O.... Lenoir G.M. (1996)
• Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. (PubMed id 17525340)^{1, 3, 4} Wang B....Elledge S.J. (2007)
• Coinheritance of BRCA1 and BRCA2 mutations with Fanconi anemia and Bloom syndrome mutations in Ashkenazi Jewish population: possible role in risk modification for cancer development. (PubMed id 15726604)^{1, 3, 6} Koren-Michowitz M....Amariglio N. (2005)
• A single-nucleotide polymorphism in the RAD51 gene modifies breast cancer risk in BRCA2 carriers, but not in BRCA1 carriers or noncarriers. (PubMed id 15138485)^{1, 3, 6} Kadouri L....Peretz T. (2004)
• Kin-cohort estimates for familial breast cancer risk in relation to variants in DNA base excision repair, BRCA1 interacting and growth factor genes. (PubMed id 15113441)^{1, 3, 6} Sigurdson A.J....Struewing J.P. (2004)
• Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair. (PubMed id 14636569)^{1, 3, 4} Dong Y....Shiekhattar R. (2003)
• Breast cancer risk reduction associated with the RAD51 polymorphism among carriers of the BRCA1 5382insC mutation in Poland. (PubMed id 12750242)^{1, 3, 6} Jakubowska A....Lubinski J. (2003)
• BRCA1-independent ubiquitination of FANCD2. (PubMed id 12887909)^{1, 3, 4} Vandenberg C.J....Patel K.J. (2003)
• BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage. (PubMed id 11836499)^{1, 3, 4} Yarden R.I.... Brody L.C. (2002)
• BRCA1 interacts with acetyl-CoA carboxylase through its tandem of BRCT domains. (PubMed id 12360400)^{1, 3, 4} Magnard C.... Venezia N.D. (2002)
• Progesterone receptor variant increases ovarian cancer risk in BRCA1 and BRCA2 mutation carriers who were never exposed to oral contraceptives. (PubMed id 11668223)^{1, 3, 6} Runnebaum I.B....Narod S.A. (2001)
• A single nucleotide polymorphism in the 5' untranslated region of RAD51 and risk of cancer among BRCA1/2 mutation carriers. (PubMed id 11535547)^{1, 3, 6} Wang W.W.... Struewing J.P. (2001)
• Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. (PubMed id 11239454)^{1, 3, 4} Garcia-Higuera I.... D'Andrea A.D. (2001)
• [Clinical and pathological characteristics and clinical course of patients with breast cancer and BRCA1/BRCA2 mutations] (PubMed id 11481082)^{1, 3, 6} Pericay C....Alonso C. (2001)
• A high occurrence of BRCA1 and BRCA2 mutations among Czech hereditary breast and breast-ovarian cancer families. (PubMed id 11192759)^{1, 3, 6} Machackova E....Messiaen L. (2000)
• BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. (PubMed id 10783165)^{1, 3, 4} Wang Y.... Qin J. (2000)
• Localization of BRCA1 and a splice variant identifies the nuclear localization signal. (PubMed id 8972225)^{1, 3, 4} Thakur S....Weber B.L. (1997)
• Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1. (PubMed id 8938427)^{1, 3, 4} Smith T.M....King M.C. (1996)
• Mutations in the BRCA1 gene in Japanese breast cancer patients. (PubMed id 8723683)^{1, 3, 4} Katagiri T.... Nakamura Y. (1996)
• MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks. (PubMed id 19261746)^{3, 4} Shao G.... Greenberg R.A. (2009)
• NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. (PubMed id 19261749)^{3, 4} Wang B.... Elledge S.J. (2009)
• MERIT40 facilitates BRCA1 localization and DNA damage repair. (PubMed id 19261748)^{3, 4} Feng L.... Chen J. (2009)
• ACCA phosphopeptide recognition by the BRCT repeats of BRCA1. (PubMed id 16698035)^{3, 4} Ray H.... Venezia N.D. (2006)
• A haplotype-based case-control study of BRCA1 and sporadic breast cancer risk. (PubMed id 16103107)^{3, 6} Freedman M.L....Haiman C.A. (2005)
• Breast cancer risk in BRCA1 and BRCA2 mutation carriers and polyglutamine repeat length in the AIB1 gene. (PubMed id 15900600)^{3, 6} Hughes D.J....Sinilnikova O.M. (2005)
• Age at menarche and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. (PubMed id 16049805)^{3, 6} Kotsopoulos J....Narod S.A. (2005)
• Polyglutamine repeat length in the AIB1 gene modifies breast cancer susceptibility in BRCA1 carriers. (PubMed id 14648706)^{3, 6} Kadouri L....Eeles R.A. (2004)
• Cytoplasmic mislocalization of BRCA1 caused by cancer-associated mutations in the BRCT domain. (PubMed id 14729053)^{3, 6} Rodriguez J.A....Henderson B.R. (2004)
• Loss of heterozygosity in normal breast epithelial tissue and benign breast lesions in BRCA1/2 carriers with breast cancer. (PubMed id 15104281)^{3, 6} Cavalli L.R....Haddad B.R. (2004)
• BRCA1 and BRCA2 germline mutation spectrum and frequencies in Belgian breast/ovarian cancer families. (PubMed id 15026808)^{3, 4} Claes K.... Messiaen L. (2004)
• A gene-environment interaction between occupation and BRCA1/BRCA2 mutations in male breast cancer? (PubMed id 15519522)^{3, 6} Palli D....Ottini L. (2004)
• Human claspin works with BRCA1 to both positively and negatively regulate cell proliferation. (PubMed id 15096610)^{3, 4} Lin S.-Y.... Elledge S.J. (2004)
• Accommodating risk: responses to BRCA1/2 genetic testing of women who have had cancer. (PubMed id 15144764)^{3, 6} Hallowell N....Watson M. (2004)
• [Analysis of BRCA1 mutations in Chinese patients with early onset breast cancer and affected relatives.] (PubMed id 15777502)^{3, 6} Hu Z....Shao Z.M. (2004)
• BRCA1 and BRCA2 germline mutations in Korean patients with sporadic breast cancer. (PubMed id 15365993)^{3, 4} Seo J.H.... Koo B.H. (2004)
• Long-term psychological impact of carrying a BRCA1/2 mutation and prophylactic surgery: a 5-year follow-up study. (PubMed id 14551306)^{3, 6} van Oostrom I....Tibben A. (2003)
• Twenty-three novel BRCA1 and BRCA2 sequence alterations in breast and/or ovarian cancer families in Southern Germany. (PubMed id 12938098)^{3, 4} Meyer P.... Klaes R. (2003)
• Bilateral prophylactic oophorectomy and ovarian cancer screening following BRCA1/BRCA2 mutation testing. (PubMed id 14581427)^{3, 6} Schwartz M.D....Lerman C. (2003)
• Gynecologic surgeries and risk of ovarian cancer in women with BRCA1 and BRCA2 Ashkenazi founder mutations: an Israeli population-based case-control study. (PubMed id 12865453)^{3, 6} Rutter J.L....Hartge P. (2003)
• BRCA1 and BRCA2 sequence variants in Chinese breast cancer families. (PubMed id 12442274)^{3, 4} Zhi X.... Shi Y.-R. (2002)
• Androgen receptor CAG repeat length in Jewish Israeli women who are BRCA1/2 mutation carriers: association with breast/ovarian cancer phenotype. (PubMed id 12404104)^{3, 6} Dagan E....Gershoni-Baruch R. (2002)
• [Analysis of mutation sites of BRCA1 gene in Chinese patients with breast cancer] (PubMed id 12362311)^{3, 6} Ke Y....Lu D. (2002)
• [Frequency of the 185delAG mutation in the BRCA1 gene in Chilean healthy women with family history of breast cancer] (PubMed id 12491828)^{3, 6} Jara L....Ojeda J.M. (2002)
• BRCA1 and BRCA2 mutation analysis of early-onset and familial breast cancer cases in Mexico. (PubMed id 12442275)^{3, 4} Ruiz-Flores P....Barrera-Saldana H.A. (2002)
• [Investigation of mutations of BRCA1 and BRCA2 genes in 52 breast cancer patients] (PubMed id 12101561)^{3, 6} Tereshchenko I.V....Shagiakhmetova R.A. (2002)
• Characterization of common BRCA1 and BRCA2 variants. (PubMed id 12215251)^{3, 4} Deffenbaugh A.M....Neuhausen S.L. (2002)
• All in the family: evaluation of the process and content of sisters' communication about BRCA1 and BRCA2 genetic test results. (PubMed id 11807889)^{3, 6} Hughes C....Main D. (2002)
• Phosphorylation of serine 1387 in BRCA1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation. (PubMed id 12183412)^{3, 4} Xu B.... Kastan M.B. (2002)
• BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations. (PubMed id 11739404)^{3, 4} Ye Q.... Li R. (2001)
• An evaluation of needs of female BRCA1 and BRCA2 carriers undergoing genetic counselling. (PubMed id 11073541)^{3, 6} Metcalfe K.A....Narod S.A. (2000)
• Molecular characterization of germline mutations in the BRCA1 and BRCA2 genes from breast cancer families in Taiwan. (PubMed id 10323242)^{3, 4} Li S.S.-L.... Tsai J.-H. (1999)
• The contribution of germline BRCA1 and BRCA2 mutations to familial ovarian cancer: no evidence for other ovarian cancer-susceptibility genes. (PubMed id 10486320)^{3, 4} Gayther S.A....Ponder B.A.J. (1999)
• Germline BRCA1 alterations in a population-based series of ovarian cancer cases. (PubMed id 10196379)^{3, 4} Janezic S.A.... Anton-Culver H. (1999)
• BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression. (PubMed id 9528852)^{3, 4} Jensen D.E.... Rauscher F.J. III (1998)
• Characterization of a carboxy-terminal BRCA1 interacting protein. (PubMed id 9811458)^{3, 4} Wong A.K....Bartel P.L. (1998)
• Constant denaturant gel electrophoresis (CDGE) in BRCA1 mutation screening. (PubMed id 9482581)^{3, 4} Andersen T.I.... Boerresen-Dale A.-L. (1998)
• Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-delta11b. (PubMed id 9010228)^{3, 4} Wilson C.A.... Calzone F.J. (1997)
• Mutations and polymorphisms in the familial early-onset breast cancer (BRCA1) gene. (PubMed id 8807330)^{3, 4} Couch F.J. and Weber B.L. (1996)
• Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer. (PubMed id 7894491)^{3, 4} Castilla L.H.... Weber B.L. (1994)
• BRCA1 mutations in primary breast and ovarian carcinomas. (PubMed id 7939630)^{3, 4} Futreal P.A.... Wiseman R. (1994)
• Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families. (PubMed id 7894493)^{3, 4} Friedman L.S.... King M.-C. (1994)
• Extracellular matrix enhances heregulin-dependent BRCA1 phosphorylation and suppresses BRCA1 expression through its C terminus. (PubMed id 12509456)^{1, 3} Miralem T. and Avraham H.K. (2003)
• BRCA1 and implications for response to chemotherapy in ovarian cancer. (PubMed id 19168207)^{1, 3} Quinn J.E....Harkin D.P. (2009)
• Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities. (PubMed id 18208621)^{1, 3} Press J.Z....Huntsman D.G. (2008)
• Inactivation of BRCA1 and BRCA2 in ovarian cancer. (PubMed id 12237285)^{1, 3} Hilton J.L....Buller R.E. (2002)
• Prevalence and penetrance of BRCA1 and BRCA2 mutations in a population-based series of breast cancer cases. Anglian Breast Cancer Study Group. (PubMed id 11044354)^{1, 3} (2000)
• BRCA1 and BRCA2 mutations in women of different ethnicities undergoing testing for hereditary breast-ovarian cancer. (PubMed id 19241424)^{1, 3} Hall M.J....Noll W.W. (2009)
• [BRCA1 and BRCA2 mutations in families studied in the program of genetic counselling in cancer of the Valencian community (Spain)] (PubMed id 18279628)^{1, 3} Esteban Cardenosa E....Salas Trejo D. (2008)
• Reproductive risk factors for ovarian cancer in carriers of BRCA1 or BRCA2 mutations: a case-control study. (PubMed id 17196508)^{1, 3} McLaughlin J.R....Narod S.A. (2007)
• Mutations of the BRCA1 and BRCA2 genes in patients with bilateral breast cancer. (PubMed id 11556836)^{1, 3} Steinmann D....Dork T. (2001)
• Phosphatidylinositol 3-kinase/Akt signaling enhances nuclear localization and transcriptional activity of BRCA1. (PubMed id 17428466)^{1, 3} Hinton C.V....Thompson M.E. (2007)
• Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha. (PubMed id 12438214)^{1, 3} Liu Y....Hsu L.C. (2002)
• Tumor suppressor BRCA1 is expressed in prostate cancer and controls insulin-like growth factor I receptor (IGF-IR) gene transcription in an androgen receptor-dependent manner. (PubMed id 19223505)^{1, 3} Schayek H....Werner H. (2009)
• Is there any relationship between BRCA1 gene mutation and pancreatic cancer development? (PubMed id 19140568)^{1, 3} Lawniczak M....StarzyA8ska T. (2008)
• Evaluation of BRCA1 and BRCA2 mutations and risk-prediction models in a typical Asian country (Malaysia) with a relatively low incidence of breast cancer. (PubMed id 18627636)^{1, 3} Thirthagiri E....Teo S.H. (2008)
• Involvement of a specificity proteins-binding element in regulation of basal and estrogen-induced transcription activity of the BRCA1 gene. (PubMed id 18377656)^{1, 3} Hockings J.K....Romagnolo D.F. (2008)
• Large genomic rearrangement in BRCA1 and BRCA2 and clinical characteristics of men with breast cancer in the United States. (PubMed id 17592676)^{1, 3} Tchou J....Nathanson K.L. (2007)
• Population BRCA1 and BRCA2 mutation frequencies and cancer penetrances: a kin-cohort study in Ontario, Canada. (PubMed id 17148771)^{1, 3} Risch H.A....Narod S.A. (2006)

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