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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

BRCA1 Gene

protein-coding   GIFtS: 73
GCID: GC17M041197

Breast Cancer 1, Early Onset

Alzheimer's & Parkinson's Diseases Congress
  See related diseases

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Breast Cancer 1, Early Onset1 2     BRCC12
RNF532 3     IRIS2
RING Finger Protein 532 3     PPP1R532
BROVCA12 5     BRCA1/BRCA2-Containing Complex, Subunit 12
PNCA42 5     Breast And Ovarian Cancer Susceptibility Protein 12
PSCP2 5     Breast And Ovarian Cancer Sususceptibility Protein 12
BRCA1/BRCA2-Containing Complex1     Breast Cancer Type 1 Susceptibility Protein2
Protein Phosphatase 11     Protein Phosphatase 1, Regulatory Subunit 532
Regulatory Subunit 531     EC 6.3.2.-3
Subunit 11     EC 6.3.28

External Ids:    HGNC: 11001   Entrez Gene: 6722   Ensembl: ENSG000000120487   OMIM: 1137055   UniProtKB: P383983   
ORGUL members:         

Export aliases for BRCA1 gene to outside databases

Previous GC identifers: GC17P062255 GC17M043361 GC17M041105 GC17M041569 GC17M038450 GC17M036962

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BRCA1 Gene:
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as
a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal
transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance
complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also
interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of
double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of
inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a
role in modulating the subcellular localization and physiological function of this gene. Many alternatively
spliced transcript variants, some of which are disease-associated mutations, have been described for this gene,
but the full-length natures of only some of these variants has been described. A related pseudogene, which is
also located on chromosome 17, has been identified. (provided by RefSeq, May 2009)

GeneCards Summary for BRCA1 Gene: 
BRCA1 (breast cancer 1, early onset) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with BRCA1 include breast cancer, and ovarian cancer, and among its related super-pathways are Fanconi's Anaemia Pathway and Cell cycle Transition and termination of DNA replication. GO annotations related to this gene include transcription coactivator activity and RNA binding.

UniProtKB/Swiss-Prot: BRCA1_HUMAN, P38398
Function: E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin
chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear
whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase
activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range
of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic
stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to
mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2
phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for
FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by
binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous
recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly
through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks.
Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on
DNA damage via BRCA1-mediated ubiquitination of RBBP8

Gene Wiki entry for BRCA1 (Talk:BRCA1) Gene

PharmGKB "VIP" summary for BRCA1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BRCA1 gene promoter:
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBRCA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for BRCA1

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BRCA1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.31

BRCA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRCA1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M041197:  view genomic region     (about GC identifiers)

41,196,312 bp from pter      End:
41,277,500 bp from pter
81,189 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BRCA1_HUMAN, P38398 (See protein sequence)
Recommended Name: Breast cancer type 1 susceptibility protein  
Size: 1863 amino acids; 207721 Da
Subunit: Heterodimer with BARD1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains
BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the MRE11-RAD50-NBN protein (MRN) complex. This association could be
a dynamic process changing throughout the cell cycle and within subnuclear domains. Component of the BRCA1-A
complex, at least composed of the BRCA1, BARD1, UIMC1, BRCC3, BRE and BABAM1. Interacts (via the BRCT domains)
with FAM175A. Component of the BRCA1-RBBP8 complex. Interacts (via the BRCT domains) with RBBP8 ('Ser-327'
phosphorylated form); the interaction ubiquitinates RBBP8, regulates CHEK1 activation, and involves RBBP8 in
BRCA1-dependent G2/M checkpoint control on DNA damage. Associates with RNA polymerase II holoenzyme. Interacts
with SMC1A and COBRA1. Interacts (via BRCT domains) with BRIP1 (phosphorylated form). Interacts with FANCD2
(ubiquitinated form). Interacts with BAP1. Interacts with DCLRE1C and CLSPN. Interacts with H2AFX (phosphorylated
on 'Ser-140'). Interacts with CHEK1 and CHEK2. Interacts with BRCC3. Interacts (via the BRCT domains) with ACACA
(phosphorylated form); the interaction prevents dephosphorylation of ACACA. Interacts with AURKA. Interacts with
UBXN1. Part of a trimeric complex containing BRCA1, BRCA2 and PALB2. Interacts directly with PALB2; the
interaction is essential for its function in HRR. Interacts directly with BRCA2; the interaction occurs only in
the presence of PALB2 which serves as the bridging protein. Interacts (via the BRCT domains) with LMO4; the
interaction represses the transcriptional activity of BRCA1. Interacts with KIAA0101/PAF15
Subcellular location: Nucleus. Chromosome (By similarity). Note=Localizes at sites of DNA damage at double-strand
breaks (DSBs); recruitment to DNA damage sites is mediated by the BRCA1-A complex
Subcellular location: Isoform 3: Cytoplasm
Subcellular location: Isoform 5: Cytoplasm
6/20 PDB 3D structures from and Proteopedia for BRCA1 (see all 20):
1JM7 (3D)        1JNX (3D)        1N5O (3D)        1OQA (3D)        1T15 (3D)        1T29 (3D)    
Secondary accessions: O15129 Q3LRJ0 Q3LRJ6 Q6IN79 Q7KYU9
Alternative splicing, Alternative initiation: 6 isoforms:  P38398-1   P38398-2   P38398-3   P38398-4   P38398-5   P38398-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BRCA1: NX_P38398

Explore proteomics data for BRCA1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation at Ser-308 by AURKA is required for normal cell cycle progression from G2 to mitosis.
    Phosphorylated in response to IR, UV, and various stimuli that cause checkpoint activation, probably by ATM or
    ATR. Phosphorylation at Ser-988 by CHEK2 regulates mitotic spindle assembly
  • UniProtKB: Autoubiquitinated, undergoes 'Lys-6'-linked polyubiquitination. 'Lys-6'-linked polyubiquitination does not promote
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P38398

  • 4/51 DME Specific Peptides for BRCA1 (P38398) (see all 51)

    BRCA1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BRCA1 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_009225.1  NP_009228.2  NP_009229.2  NP_009230.2  NP_009231.2  

    ENSEMBL proteins: 
     ENSP00000350283   ENSP00000417148   ENSP00000465818   ENSP00000467329   ENSP00000465347  
     ENSP00000418775   ENSP00000418960   ENSP00000418548   ENSP00000420705   ENSP00000419481  
     ENSP00000420412   ENSP00000418819   ENSP00000418212   ENSP00000417241   ENSP00000397145  
     ENSP00000419274   ENSP00000419988   ENSP00000420253   ENSP00000418986   ENSP00000419103  
     ENSP00000420201   ENSP00000417554   ENSP00000417988   ENSP00000420781   ENSP00000326002  
     ENSP00000312236   ENSP00000246907   ENSP00000338007   ENSP00000310938  
    Reactome Protein details: P38398
    Human Recombinant Protein Products for BRCA1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for BRCA1
    GenScript Custom Purified and Recombinant Proteins Services for BRCA1
    Novus Biologicals BRCA1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BRCA1 

    Gene Ontology (GO): 5/16 cellular component terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex NAS14976165
    GO:0000793condensed chromosome ----
    GO:0000794condensed nuclear chromosome ----
    GO:0001726ruffle IDA--
    GO:0005634nucleus IDA17525340

    BRCA1 for ontologies           About GeneDecksing

    BRCA1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of BRCA1
    R&D Systems Antibodies for BRCA1
    Cell Signaling Technology (CST) Antibodies for BRCA1 
    OriGene Antibodies for BRCA1
    OriGene Custom Antibody Services for BRCA1
    GenScript Superior Antibodies for BRCA1
    Novus Biologicals BRCA1 Antibodies
    Abcam antibodies for BRCA1
    Cloud-Clone Corp. Antibodies for BRCA1 
    ThermoFisher Antibodies for BRCA1
    LSBio Antibodies in human, mouse, rat for BRCA1 

    Assay Products for BRCA1: 
    EMD Millipore Kits and Assays for the Analysis of BRCA1
    OriGene Custom Assay Services for BRCA1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for BRCA1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BRCA1 
    Cloud-Clone Corp. CLIAs for BRCA1

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits
    RNF: RING-type (C3HC4) zinc fingers

    5/7 InterPro protein domains (see all 7):
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR011364 BRCA1
     IPR018957 Znf_C3HC4_RING-type
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry P38398

    ProtoNet protein and cluster: P38398

    3 Blocks protein domains:
    IPB001357 BRCT domain
    IPB001841 Zn-finger
    IPB002378 Breast cancer type I susceptibility protein signature

    UniProtKB/Swiss-Prot: BRCA1_HUMAN, P38398
    Domain: The BRCT domains recognize and bind phosphorylated pSXXF motif on proteins. The interaction with the
    phosphorylated pSXXF motif of FAM175A/Abraxas, recruits BRCA1 at DNA damage sites
    Domain: The RING-type zinc finger domain interacts with BAP1
    Similarity: Contains 2 BRCT domains
    Similarity: Contains 1 RING-type zinc finger

    BRCA1 for domains           About GeneDecksing

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BRCA1_HUMAN, P38398
    Function: E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin
    chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear
    whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase
    activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range
    of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic
    stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to
    mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2
    phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for
    FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by
    binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous
    recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly
    through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks.
    Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on
    DNA damage via BRCA1-mediated ubiquitination of RBBP8
    Enzyme regulation: The E3 ubiquitin-protein ligase activity is inhibited by phosphorylation by AURKA. Activity is
    increased by phosphatase treatment

         Genatlas biochemistry entry for BRCA1:
    nuclear cell cycle regulated phosphoprotein of breast epithelium,located at the centrosome during M
    phase,associating with RAD51 (RECA) at S phase of mitosis,putative negative regulator of cell growth (in a
    RB-dependent fashion),phosphorylated by ATM protein kinase in response to ionizing radiation induced DNA
    damage,then activating DNA repair through homologous recombination in cooperation with BRCA2,RAD51 and
    RAD52,P-BRCA,also complexing with RNA polymerase II holoenzyme,may also regulate transcription,recruiting CREBBP
    and interacting with components of the histone deacetylase complex,mediating ubiquitin-conjugating enzyme
    (E2)-dependent ubiquitination through the RING finger domain,induction of BRCA1 triggers JNK/SAPK (MAPK8)
    dependent apoptosis through induction of DDIT1 (GADD45)

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS9662397
    GO:0003684damaged DNA binding ----
    GO:0003713transcription coactivator activity NAS15572661
    GO:0003723RNA binding IDA12419249
    GO:0004842contributes to ubiquitin-protein ligase activity IDA17349954
    BRCA1 for ontologies           About GeneDecksing

         7 GenomeRNAi human phenotypes for BRCA1:
     Decreased homologous recombina  Decreased viability of wild-ty  Decreased viability with cispl  Increased G1 DNA content 
     Increased cell death HMECs cel  Synthetic lethal with cisplati  Upregulation of Wnt/beta-caten 

         15/23 MGI mutant phenotypes (inferred from 21 alleles(MGI details for Brca1) (see all 23):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  mortality/aging  muscle 

    BRCA1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for BRCA1: Brca1tm2.1Cxd Brca1tm1Bhk Brca1tm1Mak Brca1tm1Rfo Brca1tm1.1Brn Brca1tm1Whl
                                                         Brca1tm1Cxd Brca1tm1Arge

       inGenious Targeting Laboratory - Custom generated mouse model solutions for BRCA1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BRCA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BRCA1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BRCA1 

    miRTarBase miRNAs that target BRCA1:
    hsa-mir-146a (MIRT001920), hsa-mir-24 (MIRT004836), hsa-mir-15a (MIRT003333), hsa-mir-16 (MIRT003328), hsa-mir-212 (MIRT003967)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BRCA1
    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate BRCA1 (see all 30):
    hsa-miR-4291 hsa-miR-3934 hsa-miR-520d-5p hsa-miR-125a-3p hsa-miR-522 hsa-miR-944 hsa-miR-450b-3p hsa-miR-132
    SwitchGear 3'UTR luciferase reporter plasmidBRCA1 3' UTR sequence
    Inhib. RNA
    EMD Millipore RNAi Products for the Analysis of BRCA1 Gene knock-down
    OriGene RNAi products in human, mouse, rat for BRCA1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BRCA1

    Gene Editing
    DNA2.0 Custom Protein Engineering Service for BRCA1
    Sirion Biotech Customized adenovirus for overexpression of BRCA1

    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for BRCA1 (see all 31)
    OriGene ORF clones in mouse, rat for BRCA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): BRCA1 (NM_007294)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BRCA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRCA1

    Cell Line
    GenScript Custom overexpressing Cell Line Services for BRCA1
    Search LifeMap BioReagents cell lines for BRCA1
    In Situ Assay

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRCA1

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BRCA1 About   (see all 42)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Fanconi Anemia pathway
    Fanconi's Anaemia Pathway0.43
    BARD1 signaling events0.41
    Fanconi Anemia pathway0.43
    2Cell cycle Transition and termination of DNA replacation
    Cell cycle Transition and termination of DNA replication0.95
    Cell cycle Transition and termination of DNA replacation0.95
    3Meiotic Synapsis
    Meiotic Synapsis0.70
    Meiotic Recombination0.62
    Chromosome Maintenance0.56
    4Homologous Recombination Repair
    Homologous recombination repair of replication-independent double-strand breaks0.71
    Homologous Recombination Repair0.71
    Double-Strand Break Repair0.71
    5Recruitment of repair and signaling proteins to double-strand breaks
    Recruitment of repair and signaling proteins to double-strand breaks0.62
    ATM mediated phosphorylation of repair proteins0.62
    ATM mediated response to DNA double-strand break0.62

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/10 EMD Millipore Pathways for BRCA1 (see all 10)
        DNA damage ATM/ATR regulation of G1/S checkpoint
    Development VEGF signaling and activation
    Cell cycle Regulation of G1/S transition (part 1)
    DNA damage DNA-damage-induced responses

    5/11 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for BRCA1 (see all 11)
        BRCA1 Pathway
    Molecular Mechanisms of Cancer
    JAK-STAT Pathway
    Estrogen Pathway
    DNA Damage Induced 14-3-3Sigma Signaling

    2 Cell Signaling Technology (CST) Pathways for BRCA1
        Cell Cycle / Checkpoint Control
    DNA Damage

    5/8 GeneGo (Thomson Reuters) Pathways for BRCA1 (see all 8)
        DNA damage Role of Brca1 and Brca2 in DNA repair
    DNA damage ATM/ATR regulation of G1/S checkpoint
    DNA damage NHEJ mechanisms of DSBs repair
    Cell cycle Transition and termination of DNA replication
    Cell cycle Regulation of G1/S transition (part 1)

    5/14 BioSystems Pathways for BRCA1 (see all 14)
        DNA damage response
    Integrated Breast Cancer Pathway
    Signaling Pathways in Glioblastoma
    Androgen receptor signaling pathway
    Prostate Cancer

    5/13        Reactome Pathways for BRCA1 (see all 13)
        ATM mediated response to DNA double-strand break
    DNA Repair
    Homologous recombination repair of replication-independent double-strand breaks
    Recruitment of repair and signaling proteins to double-strand breaks
    ATM mediated phosphorylation of repair proteins

    4         Kegg Pathways  (Kegg details for BRCA1):
        Fanconi anemia pathway
    Ubiquitin mediated proteolysis
    PI3K-Akt signaling pathway
    MicroRNAs in cancer

    UniProtKB/Swiss-Prot: BRCA1_HUMAN, P38398
    Pathway: Protein modification; protein ubiquitination

    BRCA1 for pathways           About GeneDecksing


        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for BRCA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/382 Interacting proteins for BRCA1 (P383981, 2, 3 ENSP000003502834) via UniProtKB, MINT, STRING, and/or I2D (see all 382)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRIP1Q9BX631, 2, 3, ENSP000002590084EBI-349905,EBI-3509650 MINT-19306 MINT-19307 MINT-5115454 MINT-19369 MINT-5115319 MINT-5115375 MINT-5115552 MINT-19368 MINT-5115303 MINT-5115348 MINT-8141011 MINT-8140834 MINT-8140990 I2D: score=4 STRING: ENSP00000259008
    HIST1H4LP628052, 3, ENSP000003482584MINT-2490745 I2D: score=1 STRING: ENSP00000348258
    HIST1H4AP628052, 3MINT-2490745 I2D: score=1 
    HIST1H4BP628052, 3MINT-2490745 I2D: score=1 
    HIST1H4CP628052, 3MINT-2490745 I2D: score=1 
    About this table

    Gene Ontology (GO): 5/48 biological process terms (GO ID links to tree view) (see all 48):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000724double-strand break repair via homologous recombination TAS--
    GO:0006260DNA replication ----
    GO:0006281DNA repair TAS--
    GO:0006301postreplication repair IDA17349954
    GO:0006302double-strand break repair TAS--

    BRCA1 for ontologies           About GeneDecksing

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    BRCA1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for BRCA1

    10/99 Novoseek inferred chemical compound relationships for BRCA1 gene (see all 99)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 70.6 284 18377656 (7), 9655254 (7), 8895509 (5), 17505062 (4) (see all 99)
    tamoxifen 57 61 11710890 (7), 18997820 (6), 11870509 (4), 11130383 (4) (see all 29)
    progesterone 56.7 72 18197009 (4), 16109739 (4), 15816544 (3), 11981002 (2) (see all 42)
    mitomycin c 36.7 20 20174566 (3), 14751517 (3), 11406561 (2), 12007633 (1) (see all 9)
    cisplatin 32.9 95 16165098 (6), 19690636 (6), 19270496 (6), 18402708 (6) (see all 31)
    indole-3-carbinol 30.2 13 16434996 (5), 10868478 (2), 16152627 (1), 19622773 (1) (see all 5)
    docetaxel 21.8 23 18402708 (4), 18591931 (3), 19002265 (3), 11400119 (2) (see all 8)
    paclitaxel 21.5 35 16639080 (5), 12717416 (4), 19697632 (3), 19690636 (3) (see all 18)
    sodium bisulfite 20.9 2 17369979 (1), 15252835 (1)
    camptothecin 18.9 10 12955088 (2), 12007633 (1), 15258697 (1), 9679765 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about BRCA1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BRCA1 gene (12 alternative transcripts): 
    NM_007294.3  NM_007297.3  NM_007298.3  NM_007299.3  NM_007300.3  NM_007295.2  NM_007296.2  NM_007301.2  
    NM_007302.2  NM_007303.2  NM_007305.2  NM_007306.2  

    Unigene Cluster for BRCA1:

    Breast cancer 1, early onset
    Hs.194143  [show with all ESTs]
    Unigene Representative Sequence: NM_007300
    18/31 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 31):
    ENST00000357654(uc010whl.2 uc010whm.2 uc002icp.4 uc010whp.2)
    ENST00000468300 ENST00000586385 ENST00000591534 ENST00000591849 ENST00000493795(uc010whq.1)
    ENST00000471181(uc002idc.1 uc010whr.1 uc010cyz.2 uc010cza.2 uc010wht.1)
    ENST00000461221(uc010cyy.1) ENST00000491747 ENST00000484087 ENST00000478531
    ENST00000493919 ENST00000472490 ENST00000487825 ENST00000461574 ENST00000467274(uc002idd.3 uc002ide.1)
    ENST00000412061(uc002icu.3 uc002ict.3 uc002icq.3) ENST00000470026

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat BRCA1
    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate BRCA1 (see all 30):
    hsa-miR-4291 hsa-miR-3934 hsa-miR-520d-5p hsa-miR-125a-3p hsa-miR-522 hsa-miR-944 hsa-miR-450b-3p hsa-miR-132
    SwitchGear 3'UTR luciferase reporter plasmidBRCA1 3' UTR sequence
    Inhib. RNA
    EMD Millipore RNAi Products for the Analysis of BRCA1 Gene knock-down
    OriGene RNAi products in human, mouse, rat for BRCA1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BRCA1
    OriGene clones in human, mouse for BRCA1 (see all 31)
    OriGene ORF clones in mouse, rat for BRCA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): BRCA1 (NM_007294)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BRCA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRCA1
    OriGene qSTAR qPCR primer pairs in human, mouse for BRCA1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BRCA1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BRCA1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BRCA1

    Additional mRNA sequence: 

    AB621825.1 AF005068.1 AK293762.1 AK307553.1 AK308084.1 AK316200.1 AY354539.2 AY751490.1 
    BC012577.1 BC030969.1 BC038947.1 BC046142.1 BC062429.1 BC072418.1 BC085615.1 BC106745.1 
    BC106746.1 BC114511.1 BC114562.1 BC115037.1 DQ333386.1 DQ333387.1 DQ363751.1 JN686490.1 
    NR_027676.1 U14680.1 U64805.1 U68041.1 Y08864.1 

    12 DOTS entries:

    DT.313524  DT.91764293  DT.100785659  DT.100785660  DT.100785657  DT.91764294  DT.102831055  DT.120969440 
    DT.86851763  DT.91764295  DT.426829  DT.95149213 

    24/146 AceView cDNA sequences (see all 146):

    BU617173 AA086435 AU122476 BU194336 BM988066 U14680 CB155501 BU155689 
    BC046142 CB108172 BQ215100 BM755214 BM755305 AU125312 BG257190 BG681276 
    BQ683955 BQ676829 BU147444 CB158976 NM_007295 BC030969 AA486004 AL043576 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for BRCA1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a ·
    SP1:                    -                                                                                         -                                             
    SP2:                                                  -                                                           -                                             
    SP3:                                                                                                  -     -     -                                             
    SP4:                    -                                                                             -     -     -                                             
    SP5:                                                                                -     -           -     -     -                                             

    ExUns: 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23
    SP1:  -                                             
    SP2:  -                                             
    SP3:  -                                             
    SP4:  -                                             
    SP5:  -                                             

    ECgene alternative splicing isoforms for BRCA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BRCA1 expression in normal human tissues (normalized intensities)      BRCA1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    BRCA1 Expression
    About this image

    BRCA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
             Primordial Germ Cells Primitive Gonad
     Smooth Muscle (Muscoskeletal System)
             Human Intestinal Smooth Muscle Cells (HISMC)   
     Intestine (Muscoskeletal System)
             Human Intestinal Smooth Muscle Cells (HISMC)   
     Testis (Reproductive System)
             Primary Spermatocyte Seminiferous Tubules
     Skeletal Muscle (Muscoskeletal System)
             Human Skeletal Muscle Myoblast (HSkMM)   

    See BRCA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BRCA1

    SOURCE GeneReport for Unigene cluster: Hs.194143

    UniProtKB/Swiss-Prot: BRCA1_HUMAN, P38398
    Tissue specificity: Isoform 1 and isoform 3 are widely expressed. Isoform 3 is reduced or absent in several breast
    and ovarian cancer cell lines

        SABiosciences Expression via Pathway-Focused PCR Arrays including BRCA1 (see all 13): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

    OriGene qSTAR qPCR primer pairs in human, mouse for BRCA1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat BRCA1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BRCA1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BRCA1
    In Situ
    Assay Products:

    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRCA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for BRCA1 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    Gene Description Human
    (Mus musculus)
    Mammalia Brca11 , 5 breast cancer 11, 5 74.35(n)1
      11 (65.18 cM)5
    121891  NM_009764.31  NP_033894.31 
    (Gallus gallus)
    Aves BRCA11 breast cancer 1, early onset 50.01(n)
      373983  NM_204169.1  NP_989500.1 
    (Anolis carolinensis)
    Reptilia BRCA16
    Uncharacterized protein
    1 ↔ 1
    possible ortholog
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.121052 Xenopus laevis breast and ovarian cancer susceptibility more 79.05(n)    AF416868.1 
    (Danio rerio)
    Actinopterygii btr316
    bloodthirsty-related gene family, member 31
    1 ↔ 1

    ENSEMBL Gene Tree for BRCA1 (if available)
    TreeFam Gene Tree for BRCA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to Build 68)
    About This Section
    Paralogs for BRCA1 gene
    18/35 SIMAP similar genes for BRCA1 using alignment to 70 protein entries:     BRCA1_HUMAN (see all proteins) (see all similar genes):
    TRIM40    LONRF1    LONRF2    LONRF3    SH3RF1    TRIM31
    RAD18    RNF138    RFWD2    TRIM64C    TRIM73    TRIM5
    HLTF    RNF168    LNX1    PDZRN4    TRIM26    TRIM64

    BRCA1 for paralogs           About GeneDecksing

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: BRCA1_HUMAN, P38398
    Polymorphism: There is evidence that the presence of the rare form of Gln-356-Arg and Leu-871-Pro polymorphisms
    may be associated with an increased risk for developing ovarian cancer

    10/3358 SNPs in BRCA1 are shown (see all 3358)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    Chr 17 posSequence#AA
    Breast cancer (BC)4--see VAR_0632122 M K mis40--------
    A breast cancer sample4--see VAR_0359492 G C mis40--------
    Ovarian cancer (OC)4--see VAR_0207022 C R mis40--------
    Breast cancer (BC)4--see VAR_0077582 C G mis40--------
    Breast cancer (BC)4--see VAR_0077812 V A mis40--------
    Familial breast-ovarian cancer 1 (BROVCA1)4--see VAR_0206972 R G mis40--------
    Breast cancer (BC)4--see VAR_0077562 L S mis40--------
    Ovarian cancer (OC)4--see VAR_0207032 R W mis40--------
    Breast cancer (BC)4--see VAR_0206832 D Y mis40--------
    Familial breast-ovarian cancer 1 (BROVCA1)4--see VAR_0206952 S Y mis40--------

    HapMap Linkage Disequilibrium report for BRCA1 (41196312 - 41277500 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for BRCA1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2667044CNV Deletion23128226
    esv2672913CNV Deletion23128226
    esv2715952CNV Deletion23290073
    nsv457743CNV Loss19166990
    nsv470587CNV Loss18288195
    nsv908259CNV Loss21882294
    nsv827999CNV Loss20364138
    esv33998OTHER Inversion15654335

    Human Gene Mutation Database (HGMD): BRCA1

    Locus Specific Mutation Databases (LSDB): BRCA1
    3 SABiosciences Cancer Mutation PCR Assays for BRCA1:
    Cosmic IdAA Change
    SeqTarget long-range PCR primers for resequencing BRCA1
    DNA2.0 Custom Variant and Variant Library Synthesis for BRCA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 113705   
    OMIM disorders: 604370  
    UniProtKB/Swiss-Prot: BRCA1_HUMAN, P38398
  • Breast cancer (BC) [MIM:114480]: A common malignancy originating from breast epithelial tissue. Breast
    neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common
    type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated
    by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different
    families or even in the same case. Note=Disease susceptibility is associated with variations affecting the gene
    represented in this entry. Mutations in BRCA1 are thought to be responsible for 45% of inherited breast cancer.
    Moreover, BRCA1 carriers have a 4-fold increased risk of colon cancer, whereas male carriers face a 3-fold
    increased risk of prostate cancer. Cells lacking BRCA1 show defects in DNA repair by homologous recombination
  • Familial breast-ovarian cancer 1 (BROVCA1) [MIM:604370]: A condition associated with familial
    predisposition to cancer of the breast and ovaries. Characteristic features in affected families are an early age
    of onset of breast cancer (often before age 50), increased chance of bilateral cancers (cancer that develop in
    both breasts, or both ovaries, independently), frequent occurrence of breast cancer among men, increased
    incidence of tumors of other specific organs, such as the prostate. Note=Disease susceptibility is associated
    with variations affecting the gene represented in this entry. Mutations in BRCA1 are thought to be responsible
    for more than 80% of inherited breast-ovarian cancer
  • Ovarian cancer (OC) [MIM:167000]: The term ovarian cancer defines malignancies originating from ovarian
    tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the
    most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of
    late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry
  • Pancreatic cancer 4 (PNCA4) [MIM:614320]: A malignant neoplasm of the pancreas. Tumors can arise from
    both the exocrine and endocrine portions of the pancreas, but 95% of them develop from the exocrine portion,
    including the ductal epithelium, acinar cells, connective tissue, and lymphatic tissue. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry

  • 20/119 diseases for BRCA1 (see all 119):    About MalaCards
    breast cancer    ovarian cancer    hereditary breast ovarian cancer    pancreatic cancer
    cystadenoma    primary peritoneal carcinoma    fallopian tube cancer    radiation induced cancer
    breast-ovarian cancer, familial, 1    brca1 hereditary breast and ovarian cancer    sporadic breast cancer    hereditary breast cancer
    bilateral breast cancer    peritoneal carcinoma    familial breast cancer    ovarian cystadenoma
    breast carcinoma in situ    breast cancer, somatic    premature menopause    canavan disease

    10 diseases from the University of Copenhagen DISEASES database for BRCA1:
    Ovarian cancer     Breast cancer     Fallopian tube cancer     Aplastic anemia
    Autosomal dominant disease     Peritoneal carcinoma     Carcinoma     Ataxia telangiectasia
    Ductal carcinoma in situ     Prostate cancer

    BRCA1 for disorders           About GeneDecksing

    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/95 Novoseek inferred disease relationships for BRCA1 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian cancer 95.8 2220 10560359 (7), 9796975 (7), 20223018 (7), 10978226 (6) (see all 99)
    breast cancer 93.5 4077 15564800 (9), 20223018 (9), 11710890 (8), 11044354 (8) (see all 99)
    germ-line mutation 91.3 221 17001151 (4), 8875917 (4), 10969800 (3), 16085232 (3) (see all 99)
    prophylactic oophorectomy 90.9 57 15863145 (6), 10469748 (5), 9148160 (3), 12023993 (3) (see all 39)
    bilateral breast cancer 85.2 38 11556836 (3), 10573018 (2), 17557253 (2), 19372713 (2) (see all 25)
    cancer 82.6 997 14966099 (7), 12237281 (5), 10972993 (4), 12237282 (4) (see all 99)
    breast carcinoma 75.1 214 9840533 (5), 9241077 (4), 9699523 (4), 11859870 (3) (see all 99)
    fanconis anemia 74.6 23 12483114 (2), 12967657 (2), 16116421 (2), 15726604 (1) (see all 19)
    tumors 73.4 1603 15868446 (10), 11773283 (8), 10686936 (8), 15712267 (7) (see all 99)
    ovarian carcinoma 72.7 115 10686936 (5), 16284991 (4), 10388472 (3), 9661879 (3) (see all 65)

    Genatlas disease: BRCA1
    breast carcinoma,early onset,high tumor grade,negative estrogen and progesterone receptor status,and high
    proliferative rate,breast ovarian cancer family,familial site-specific ovarian cancer,Lynch syndrome II (see
    TSG17B),excluding familial male breast cancer,including early onset gastric carcinoma,not frequently prostate

    GeneTests: BRCA1
    GeneReviews: BRCA1
    Genetic Association Database (GAD): BRCA1
    Human Genome Epidemiology (HuGE) Navigator: BRCA1 (824 documents)
    Tumor Gene Database (TGDB): BRCA1

    Export disorders for BRCA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BRCA1 gene, integrated from 9 sources (see all 3085) (see top 10):
    (articles sorted by number of sources associating them with BRCA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel germline mutations in the BRCA1 and BRCA2 genes in Indian breast and breast-ovarian cancer families. (PubMed id 14722926)1, 2, 4, 9 Valarmathi M.T.... Das S.N. (2004)
    2. One in 10 ovarian cancer patients carry germ line BRCA1 or BRCA2 mutations: results of a prospective study in Southern Sweden. (PubMed id 14746861)1, 2, 4, 9 Malander S.... Borg A. (2004)
    3. BRCA1 and BRCA2 germline mutations in Korean patients with sporadic breast cancer. (PubMed id 15365993)1, 2, 4 Seo J.H.... Koo B.H. (2004)
    4. BRCA1 and BRCA2 mutations in women of different ethnicities undergoing testing for hereditary breast-ovarian cancer. (PubMed id 19241424)1, 4, 9 Hall M.J....Noll W.W. (2009)
    5. [BRCA1 and BRCA2 mutations in families studied in the program of genetic counselling in cancer of the Valencian community (Spain)] (PubMed id 18279628)1, 4, 9 Esteban Cardenosa E....Salas Trejo D. (2008)
    6. Mutations of the BRCA1 and BRCA2 genes in patients with bilateral breast cancer. (PubMed id 11556836)1, 4, 9 Steinmann D....Dork T. (2001)
    7. Is there any relationship between BRCA1 gene mutation and pancreatic cancer development? (PubMed id 19140568)1, 4, 9 Lawniczak M....StarzyA8ska T. (2008)
    8. Evaluation of BRCA1 and BRCA2 mutations and risk-prediction models in a typical Asian country (Malaysia) with a relatively low incidence of breast cancer. (PubMed id 18627636)1, 4, 9 Thirthagiri E....Teo S.H. (2008)
    9. Large genomic rearrangement in BRCA1 and BRCA2 and clinical characteristics of men with breast cancer in the United States. (PubMed id 17592676)1, 4, 9 Tchou J....Nathanson K.L. (2007)
    10. Population BRCA1 and BRCA2 mutation frequencies and cancer penetrances: a kin-cohort study in Ontario, Canada. (PubMed id 17148771)1, 4, 9 Risch H.A....Narod S.A. (2006)
    11. A comprehensive model for familial breast cancer incorporating BRCA1, BRCA2 and other genes. (PubMed id 11857015)1, 4, 9 Antoniou A.C....Easton D.F. (2002)
    12. Frequency of BRCA1 and BRCA2 germline mutations in Japanese breast cancer families. (PubMed id 11149425)1, 4, 9 Ikeda N....Noguchi S. (2001)
    13. Novel germline mutations in breast cancer susceptibility genes BRCA1, BRCA2 and p53 gene in breast cancer patients from India. (PubMed id 15564800)1, 4, 9 Hedau S....Das B.C. (2004)
    14. BRCA1 and BRCA2 germline mutation analysis among Indi an women from south India: identification of four novel mutations and high-freq uency occurrence of 185delAG mutation. (PubMed id 19805903)1, 4, 9 Vaidyanathan K....Somasundaram K. (2009)
    15. Contribution of BRCA1 and BRCA2 germline mutations to the incidence of early-onset breast cancer in Cyprus. (PubMed id 17250666)1, 4, 9 Loizidou M....Kyriacou K. (2007)
    16. BRCA1, BRCA2 and TP53 mutations in very early-onset breast cancer with associated risks to relatives. (PubMed id 16644204)1, 4, 9 Lalloo F....Evans D.G. (2006)
    17. Prevalence of BRCA1 and BRCA2 mutations in women diagnosed with ductal carcinoma in situ. (PubMed id 15728167)1, 4, 9 Claus E.B....Carter D. (2005)
    18. [Mutational analysis of BRCA1 and BRCA2 genes in early-onset breast cancer patients in Shanghai] (PubMed id 16324400)1, 4, 9 Song C.G....Shao Z.M. (2005)
    19. BRCA1 and BRCA2 heterozygosity and repair of X-ray-induced DNA damage. (PubMed id 12020440)1, 4, 9 Nieuwenhuis B....Kampinga H.H. (2002)
    20. Tamoxifen and breast cancer incidence among women with inherited mutations in BRCA1 and BRCA2: National Surgical Adjuvant Breast and Bowel Project (NSABP-P1) Breast Cancer Prevention Trial. (PubMed id 11710890)1, 4, 9 King M.C....Fisher B. (2001)
    21. Involvement of BRCA1 and BRCA2 in breast cancer in a western Finnish sub-population. (PubMed id 11180449)1, 4, 9 Paakkonen K....Kere J. (2001)
    22. Germline BRCA1 mutations predispose to pancreatic adenocarcinoma. (PubMed id 18762988)1, 2, 9 Al-Sukhni W....Gallinger S. (2008)
    23. High follicular phase luteinizing hormone levels in young healthy BRCA1 mutation carriers: implications for breast and ovarian cancer risk. (PubMed id 16084122)1, 4, 9 Jernstrom H....Olsson H. (2005)
    24. Breast cancer risk and the DNA double-strand break end-joining capacity of nonhomologous end-joining genes are affected by BRCA1. (PubMed id 15256476)1, 4, 9 Bau D.T....Shen C.Y. (2004)
    25. Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. (PubMed id 11114888)1, 2, 9 Tibbetts R.S.... Abraham R.T. (2000)
    26. Elevated expression of Ki-67 identifies aggressive pr ostate cancers but does not distinguish BRCA1 or BRCA2 mutation carriers. (PubMed id 20043088)1, 4, 9 Mitra A.V.... C.S. (2010)
    27. Contralateral breast cancer risk in BRCA1 and BRCA2 m utation carriers. (PubMed id 19858402)1, 4, 9 Graeser M.K....Schmutzler R.K. (2009)
    28. Genetic analysis of BRCA1 and BRCA2 in breast/ovarian cancer families from Aragon (Spain): two novel truncating mutations and a large genomic deletion in BRCA1. (PubMed id 18176857)1, 4, 9 Miramar M.D....Garcia de Jalon A. (2008)
    29. Prevalence of BRCA1 and BRCA2 mutations in breast cancer patients from Cuba. (PubMed id 18286383)1, 4, 9 Rodriguez R.C....Narod S.A. (2008)
    30. BRCA1 germline mutations and tumor characteristics in Chinese women with familial or early-onset breast cancer. (PubMed id 18512148)1, 4, 9 Chen W....Xie Y. (2008)
    31. Prevalence of BRCA1 and BRCA2 mutations in breast cancer patients from Brazil. (PubMed id 17063270)1, 4, 9 Gomes M.C....Narod S.A. (2007)
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    33. Reproductive risk factors for ovarian cancer in carriers of BRCA1 or BRCA2 mutations: a case-control study. (PubMed id 17196508)1, 4, 9 McLaughlin J.R....Narod S.A. (2007)
    34. Contribution of germline BRCA1 and BRCA2 sequence alterations to breast cancer in Northern India. (PubMed id 17018160)1, 4, 9 Saxena S....Szabo C.I. (2006)
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    36. Analysis of BRCA1 and BRCA2 mutations in Brazilian breast cancer patients with positive family history. (PubMed id 16389418)1, 4, 9 Dufloth R.M....Schmitt F. (2005)
    37. Intra-abdominal carcinomatosis after prophylactic oophorectomy in women of hereditary breast ovarian cancer syndrome kindreds associated with BRCA1 and BRCA2 mutations. (PubMed id 15863145)1, 4, 9 Casey M.J....Lynch H.T. (2005)
    38. BRCA1 mutations and polymorphisms in a hospital-based consecutive series of breast cancer patients from Apulia, Italy. (PubMed id 16026807)1, 4, 9 Tommasi S....Paradiso A. (2005)
    39. BRCA1 mutations in a population-based study of breast cancer in Stockholm County. (PubMed id 15345109)1, 4, 9 Margolin S....Lindblom A. (2004)
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    41. Similar contributions of BRCA1 and BRCA2 germline mutations to early-onset breast cancer in Germany. (PubMed id 12774040)1, 4, 9 Hamann U....Sinn H.P. (2003)
    42. Oral contraceptives and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. (PubMed id 12464649)1, 4, 9 Narod S.A....Brunet J.S. (2002)
    43. BRCA1 and BRCA2 mutation frequency in women evaluated in a breast cancer risk evaluation clinic. (PubMed id 11844822)1, 4, 9 Shih H.A....Weber B.L. (2002)
    44. Efficacy of bilateral prophylactic mastectomy in BRCA1 and BRCA2 gene mutation carriers. (PubMed id 11698567)1, 4, 9 Hartmann L.C....Jenkins R.B. (2001)
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    47. Genetic variation in insulin-like growth factor signa ling genes and breast cancer risk among BRCA1 and BRCA2 carriers. (PubMed id 19843326)1, 4, 9 Neuhausen S.L....Gillen D.L. (2009)
    48. Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers. (PubMed id 18355772)1, 4, 9 Antoniou A.C....Easton D.F. (2008)
    49. The effect of CHEK2 missense variant I157T on the risk of breast cancer in carriers of other deleterious CHEK2 or BRCA1 mutations. (PubMed id 18930998)1, 4, 9 Cybulski C....Lubinski J. (2008)
    50. Hormone therapy and the risk of breast cancer in BRCA1 mutation carriers. (PubMed id 18812548)1, 4, 9 Eisen A....Narod S.A. (2008)
    51. Variation of breast cancer risk among BRCA1/2 carriers. (PubMed id 18182601)1, 4, 9 Begg C.B....Bernstein J.L. (2008)
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    55. Contribution of BRCA1 and BRCA2 to familial ovarian cancer: a gynecologic oncology group study. (PubMed id 11972384)1, 4, 9 Reedy M....Smith S.A. (2002)
    56. Family history of breast and ovarian cancers and BRCA1 and BRCA2 mutations in a population-based series of early-onset breast cancer. (PubMed id 11504767)1, 4, 9 Loman N....Borg A. (2001)
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    58. Pathological features and BRCA1 mutation screening in premenopausal breast cancer patients. (PubMed id 11410514)1, 4, 9 Chang J....Ragu G.C. (2001)
    59. BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function. (PubMed id 11301010)1, 2, 9 Cantor S.B....Livingston D.M. (2001)
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    63. Common variants in LSP1, 2q35 and 8q24 and breast can cer risk for BRCA1 and BRCA2 mutation carriers. (PubMed id 19656774)1, 4, 9 Antoniou A.C....Chen X. (2009)
    64. Missense polymorphisms in BRCA1 and BRCA2 and risk of breast and ovarian cancer. (PubMed id 19661094)1, 4, 9 Dombernowsky S.L....Nordestgaard B.G. (2009)
    65. BRCA1 and BRCA2 mutation prevalence and clinical characteristics of a population-based series of ovarian cancer cases from Denmark. (PubMed id 18559594)1, 4, 9 Soegaard M....Ramus S.J. (2008)
    66. BRCA1 mutations in Algerian breast cancer patients: high frequency in young, sporadic cases. (PubMed id 18645608)1, 4, 9 Uhrhammer N....Bignon Y.J. (2008)
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    68. The RAD51 135 G>C polymorphism modifies breast cancer and ovarian cancer risk in Polish BRCA1 mutation carriers. (PubMed id 17301259)1, 4, 9 Jakubowska A....Hamann U. (2007)
    69. Prevalence of BRCA1 and BRCA2 genomic rearrangements in a cohort of consecutive Italian breast and/or ovarian cancer families. (PubMed id 17333342)1, 4, 9 Buffone A....Giannini G. (2007)
    70. Familial clustering of site-specific cancer risks associated with BRCA1 and BRCA2 mutations in the Ashkenazi Jewish population. (PubMed id 16537453)1, 4, 9 Simchoni S....Levy-Lahad E. (2006)
    71. Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers. (PubMed id 16563180)1, 4, 9 Friedman E....Narod S.A. (2006)
    72. BRCA1 and BRCA2 mutations account for a large proportion of ovarian carcinoma cases. (PubMed id 16284991)1, 4, 9 Pal T....Sutphen R. (2005)
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    74. Identification of germline BRCA1 and BRCA2 genetic alterations in Greek breast cancer moderate-risk and low-risk individuals--correlation with clinicopathological data. (PubMed id 15733268)1, 4, 9 Kataki A....Konstadoulakis M. (2005)
    75. Breast-feeding and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. (PubMed id 15265971)1, 4, 9 Jernstrom H....Narod S.A. (2004)
    76. BRCA1 mutations in ovarian cancer and borderline tumours in Norway: a nested case-control study. (PubMed id 15477862)1, 4, 9 Bjorge T....Dorum A. (2004)
    77. BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair. (PubMed id 14976165)1, 2, 9 Morris J.R. and Solomon E. (2004)
    78. Oral contraceptive use and ovarian cancer risk among carriers of BRCA1 or BRCA2 mutations. (PubMed id 15545966)1, 4, 9 Whittemore A.S....Piver M.S. (2004)
    79. Association between BRCA1 mutations and ratio of female to male births in offspring of families with breast cancer, ovarian cancer, or both. (PubMed id 12928470)1, 4, 9 de la Hoya M....Caldes T. (2003)
    80. Estimates of the likely prophylactic effect of tamoxifen in women with high risk BRCA1 and BRCA2 mutations. (PubMed id 11870509)1, 4, 9 Duffy S.W. and Nixon R.M. (2002)
    81. Parity, oral contraceptives, and the risk of ovarian cancer among carriers and noncarriers of a BRCA1 or BRCA2 mutation. (PubMed id 11474660)1, 4, 9 Modan B....Piura B. (2001)
    82. Germline BRCA1 mutations in Iranian women with breast cancer. (PubMed id 11248423)1, 4, 9 Ghaderi A....Kimura H. (2001)
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    84. High proportion of missense mutations of the BRCA1 and BRCA2 genes in Japanese breast cancer families. (PubMed id 9609997)1, 2, 9 Katagiri T.... Miki Y. (1998)
    85. The average cumulative risks of breast and ovarian cancer for carriers of mutations in BRCA1 and BRCA2 attending genetic counseling units in Spain. (PubMed id 18451254)1, 4, 9 Milne R.L....Benitez J. (2008)
    86. Haplotype analysis of TP53 polymorphisms, Arg72Pro and Ins16, in BRCA1 and BRCA2 mutation carriers of French Canadian descent. (PubMed id 18402691)1, 4, 9 Cavallone L....Tonin P.N. (2008)
    87. Germline TP53 mutations in BRCA1 and BRCA2 mutation-negative French Canadian breast cancer families. (PubMed id 17541742)1, 4, 9 Arcand S.L....Tonin P.N. (2008)
    88. Prevalence and characteristics of pancreatic cancer in families with BRCA1 and BRCA2 mutations. (PubMed id 18855126)1, 4, 9 Kim D.H....Beattie M.S. (2008)
    89. BRCA1 mutations and prostate cancer in Poland. (PubMed id 18090912)1, 4, 9 Cybulski C....Lubinski J. (2008)
    90. Clinical and pathologic characteristics of patients with BRCA-positive and BRCA-negative breast cancer. (PubMed id 18779615)1, 4, 9 Atchley D.P....Arun B.K. (2008)
    91. Common variants in the ATM, BRCA1, BRCA2, CHEK2 and TP53 cancer susceptibility genes are unlikely to increase breast cancer risk. (PubMed id 17428325)1, 4, 9 Baynes C....Dunning A.M. (2007)
    92. Counting potentially functional variants in BRCA1, BRCA2 and ATM predicts breast cancer susceptibility. (PubMed id 17341484)1, 4, 9 Johnson N....Peto J. (2007)
    93. BRCA1 and TP53 mutation spectrum of breast carcinoma in an ethnic population of Kashmir, an emerging high-risk area. (PubMed id 16996204)1, 4, 9 Eachkoti R....Siddiqi M.A. (2007)
    94. BRCA1, BRCA2, TP53, and CDKN2A germline mutations in patients with breast cancer and cutaneous melanoma. (PubMed id 17624602)1, 4, 9 Monnerat C....Bressac-de Paillerets B. (2007)
    95. Breast cancer risk among male BRCA1 and BRCA2 mutation carriers. (PubMed id 18042939)1, 4, 9 Tai Y.C....Chen S. (2007)
    96. Mutational analysis of the estrogen receptor-alpha gene in familial ovarian cancer. (PubMed id 16176503)1, 4, 9 Wu H.J....Tanaka K. (2005)
    97. Male BRCA1 and BRCA2 mutation carriers: a pilot study investigating medical characteristics of patients participating in a prostate cancer prevention clinic. (PubMed id 15880530)1, 4, 9 Horsburgh S....Trachtenberg J. (2005)
    98. Atypical epithelial proliferation in fallopian tubes in prophylactic salpingo-oophorectomy specimens from BRCA1 and BRCA2 germline mutation carriers. (PubMed id 14668548)1, 4, 9 Carcangiu M.L....Pasini B. (2004)
    99. BRCA1 testing in breast and/or ovarian cancer families from northeastern France identifies two common mutations with a founder effect. (PubMed id 15131401)1, 4, 9 Muller D....Fricker J.P. (2004)
    100. BRCA mutations and risk of prostate cancer in Ashkenazi Jews. (PubMed id 15131025)1, 4, 9 Kirchhoff T....Offit K. (2004)
    101. Vascular endothelial growth factor (VEGF) levels and mutation of the BRCA1 gene in breast cancer patients. (PubMed id 15609132)1, 4, 9 Tarnowski B....Rzepka-Gorska I. (2004)
    102. TP53, BRCA1, and BRCA2 tumor suppressor genes are not commonly mutated in survivors of Hodgkin's disease with second primary neoplasms. (PubMed id 14673037)1, 4, 9 Nichols K.E....Diller L. (2003)
    103. Hereditary ovarian cancer in Poland. (PubMed id 12918074)1, 4, 9 Menkiszak J....Lubinski J. (2003)
    104. BRCA1, BRCA2 and CHEK2 (1100 del C) germline mutations in hereditary breast and ovarian cancer families in South India. (PubMed id 14507240)1, 4, 9 Rajkumar T....Shanta V. (2003)
    105. Ovarian cancer risk in Ashkenazi Jewish carriers of BRCA1 and BRCA2 mutations. (PubMed id 12473589)1, 4, 9 Satagopan J.M....Offit K. (2002)
    106. Contribution of BRCA1 and BRCA2 mutations to breast and ovarian cancer in Pakistan. (PubMed id 12181777)1, 4, 9 Liede A....Narod S.A. (2002)
    107. Tubal ligation and risk of ovarian cancer in carriers of BRCA1 or BRCA2 mutations: a case-control study. (PubMed id 11377596)1, 4, 9 Narod S.A....Neuhausen S.L. (2001)
    108. A high proportion of mutations in the BRCA1 gene in German breast/ovarian cancer families with clustering of mutations in the 3' third of the gene. (PubMed id 9760198)1, 2, 9 Dong J....Royer-Pokora B. (1998)
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    110. BRCA1 R841W: a strong candidate for a common mutation with moderate phenotype. (PubMed id 8968716)1, 2, 9 Barker D.F.... Anton-Culver H. (1996)
    111. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. (PubMed id 7545954)1, 2, 9 Miki Y.... Skolnick M.H. (1994)
    112. Excretion of estrogens, catecholestrogens and phytoes trogens in carriers of BRCA1 gene mutations: effects of metformin. (PubMed id 20429624)1, 4, 9 Berstein L.M....Adlercreutz H. (2010)
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    114. Prospective study of breast MRI in BRCA1 and BRCA2 mu tation carriers: effect of mutation status on cancer incidence. (PubMed id 19609668)1, 4, 9 Shah P....Domchek S.M. (2009)
    115. Polymorphisms in BRCA1, BRCA1-interacting genes and s usceptibility of breast cancer in Chinese women. (PubMed id 19484476)1, 4, 9 Huo X....Tang J. (2009)
    116. High frequency of BRCA1, but not CHEK2 or NBS1 (NBN), founder mutations in Russian ovarian cancer patients. (PubMed id 19338682)1, 4, 9 Suspitsin E.N....Imyanitov E.N. (2009)
    117. The Fanconi anemia family of genes and its correlatio n with breast cancer susceptibility and breast cancer features. (PubMed id 19536649)1, 4, 9 Barroso E....Ribas G. (2009)
    118. Dinucleotide repeat polymorphisms of RAD51, BRCA1, BRCA2 gene regions in breast cancer. (PubMed id 18429825)1, 4, 9 Nowacka-Zawisza M....Krajewska W.M. (2008)
    119. Expression of estrogen receptor beta in the breast carcinoma of BRCA1 mutation carriers. (PubMed id 18405391)1, 4, 9 Litwiniuk M.M....Breborowicz J. (2008)
    120. Predominant Ashkenazi BRCA1/2 mutations in families with pancreatic cancer. (PubMed id 18439109)1, 4, 9 Dagan E. (2008)
    121. Rapid progression of prostate cancer in men with a BRCA2 mutation. (PubMed id 18577985)1, 4, 9 Narod S.A....Bellati C. (2008)
    122. RAD51 135G-->C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies. (PubMed id 17999359)1, 4, 9 Antoniou A.C....Chenevix-Trench G. (2007)
    123. Determination of cancer risk associated with germ line BRCA1 missense variants by functional analysis. (PubMed id 17308087)1, 4, 9 Carvalho M.A....Monteiro A.N. (2007)
    124. Tamoxifen and contralateral breast cancer in BRCA1 and BRCA2 carriers: an update. (PubMed id 16331614)1, 4, 9 Gronwald J....Narod S.A. (2006)
    125. CAG repeat length in exon 1 of the androgen receptor gene is related to age of diagnosis but not germ line BRCA1 mutation status in ovarian cancer. (PubMed id 16515589)1, 4, 9 Kim S.C....Buller R.E. (2006)
    126. BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase. (PubMed id 16326698)1, 2, 9 Moreau K.... Venezia N.D. (2006)
    127. Prevalence of BRCA1 and BRCA2 mutations in Pakistani breast and ovarian cancer patients. (PubMed id 16998791)1, 4, 9 Rashid M.U....Hamann U. (2006)
    128. Premature menopause in patients with BRCA1 gene mutation. (PubMed id 16773440)1, 4, 9 Rzepka-Gorska I....Tol/oczko-Grabarek A. (2006)
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    130. Prognostic impact of BRCA1 pathogenic and BRCA1/BRCA2 unclassified variant mutations in patients with ovarian carcinoma. (PubMed id 16047333)1, 4, 9 Majdak E.J....De Bock G.H. (2005)
    131. Oral contraceptive use and risk of early-onset breast cancer in carriers and noncarriers of BRCA1 and BRCA2 mutations. (PubMed id 15734957)1, 4, 9 Milne R.L....Whittemore A.S. (2005)
    132. Breast cancer predisposing alleles in Poland. (PubMed id 15980987)1, 4, 9 Gorski B....Lubinski J. (2005)
    133. Germ-line mutations in BRCA1 or BRCA2 in the normal breast are associated with altered expression of estrogen-responsive proteins and the predominance of progesterone receptor A. (PubMed id 14732925)1, 4, 9 Mote P.A....Clarke C.L. (2004)
    134. Frequency of BRCA1 and BRCA2 mutations in unselected Ashkenazi Jewish patients with colorectal cancer. (PubMed id 14709740)1, 4, 9 Kirchhoff T....Offit K. (2004)
    135. Differential association of BRCA1 and BRCA2 genes with some breast cancer-associated genes in early and late onset breast tumors. (PubMed id 15576832)1, 4, 9 Chunder N....Panda C.K. (2004)
    136. BRCA1 and BRCA2 mutations in women from Shanghai China. (PubMed id 14973102)1, 4, 9 Suter N.M....Ostrander E.A. (2004)
    137. BRCA1 and BRCA2 founder mutations and the risk of colorectal cancer. (PubMed id 14709734)1, 4, 9 Niell B.L....Gruber S.B. (2004)
    138. The Norwegian founder mutations in BRCA1: high penetrance confirmed in an incident cancer series and differences observed in the risk of ovarian cancer. (PubMed id 14522380)1, 4, 9 Heimdal K....Moller P. (2003)
    139. Detection of the most frequent mutations in BRCA1 gene on polyacrylamide gels containing Spreadex Polymer NAB. (PubMed id 12937835)1, 4, 9 Janatova M....Matous B. (2003)
    140. BRCA1 wild-type allele modifies risk of ovarian cancer in carriers of BRCA1 germ-line mutations. (PubMed id 12582017)1, 4, 9 Ginolhac S.M....Sinilnikova O.M. (2003)
    141. Founder mutations in BRCA1/2 are not frequent in Canadian Ashkenazi Jewish men with prostate cancer. (PubMed id 12911837)1, 4, 9 Hamel N....Foulkes W.D. (2003)
    142. The pathology of familial breast cancer: predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2. (PubMed id 11981002)1, 4, 9 Lakhani S.R....Easton D.F. (2002)
    143. Cancer Incidence in BRCA1 mutation carriers. (PubMed id 12237281)1, 4, 9 Thompson D. and Easton D.F. (2002)
    144. Mutagen sensitivity of peripheral blood from women carrying a BRCA1 or BRCA2 mutation. (PubMed id 11890937)1, 4, 9 Trenz K....Speit G. (2002)
    145. A single nucleotide polymorphism in the RAD51 gene modifies cancer risk in BRCA2 but not BRCA1 carriers. (PubMed id 11248061)1, 4, 9 Levy-Lahad E....Gershoni-Baruch R. (2001)
    146. Breast tumor immunophenotype of BRCA1-mutation carriers is influenced by age at diagnosis. (PubMed id 11448907)1, 4, 9 Vaziri S.A....Casey G. (2001)
    147. Structure of a BRCA1-BARD1 heterodimeric RING-RING complex. (PubMed id 11573085)1, 2, 9 Brzovic P.S....Klevit R.E. (2001)
    148. The frequency of the predominant Jewish mutations in BRCA1 and BRCA2 in unselected Ashkenazi colorectal cancer patients. (PubMed id 11207040)1, 4, 9 Chen-Shtoyerman R....Theodor L. (2001)
    149. A high incidence of BRCA1 mutations in 20 breast-ovarian cancer families. (PubMed id 8554067)1, 2, 9 Serova O.... Lenoir G.M. (1996)
    150. Germline BRCA mutations denote a clinicopathologic su bset of prostate cancer. (PubMed id 20215531)1, 4, 9 Gallagher D.J....Offit K. (2010)
    151. Estrogen receptor positive breast cancers in BRCA1 mu tation carriers: clinical risk factors and pathologic features. (PubMed id 20149218)1, 4, 9 Tung N....Schnitt S.J. (2010)
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    154. Sensitivity to first-line chemotherapy for metastatic breast cancer in BRCA1 and BRCA2 mutation carriers. (PubMed id 19564533)1, 4, 9 Kriege M....Klijn J.G. (2009)
    155. Breast cancer immunohistochemical features in young w omen with BRCA 1/2 mutations. (PubMed id 19877382)1, 4, 9 Zakhartseva L.M....Shurygina O.V. (2009)
    156. CpG island tumor suppressor promoter methylation in non-BRCA-associated early mammary carcinogenesis. (PubMed id 19258476)1, 4, 9 Vasilatos S.N....Seewaldt V.L. (2009)
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    159. Polymorphisms in HPV E6/E7 protein interacted genes a nd risk of cervical cancer in Chinese women: a case-control analysis. (PubMed id 19482343)1, 4, 9 Zhou X....Shen H. (2009)
    160. Sequence variant discovery in DNA repair genes from r adiosensitive and radiotolerant prostate brachytherapy patients. (PubMed id 19638463)1, 4, 9 Pugh T.J....Moore R.A. (2009)
    161. BRCA germline mutations in Jewish patients with pancreatic adenocarcinoma. (PubMed id 19064968)1, 4, 9 Ferrone C.R....Robson M.E. (2009)
    162. Contribution of BRCA1 germ-line mutations to breast c ancer in Greece: a hospital-based study of 987 unselected breast cancer cases. (PubMed id 19491894)1, 4, 9 Armaou S....Konstantopoulou I. (2009)
    163. Potential excess mortality in BRCA1/2 mutation carriers beyond breast, ovarian, prostate, and pancreatic cancers, and melanoma. (PubMed id 19277124)1, 4, 9 Mai P.L....Wacholder S. (2009)
    164. Inhibition of poly(ADP-ribose) polymerase in tumors f rom BRCA mutation carriers. (PubMed id 19553641)1, 4, 9 Fong Bono J.S. (2009)
    165. Absence of germline BRCA1 mutations in familial pancreatic cancer patients. (PubMed id 19029836)1, 4, 9 Axilbund J.E....Klein A.P. (2009)
    166. The prevalence of BRCA1 and BRCA2 germline mutations in high-risk breast cancer patients of Chinese Han nationality: two recurrent mutations were identified. (PubMed id 17851763)1, 4, 9 Li W.F....Shao Z.M. (2008)
    167. Response to neo-adjuvant chemotherapy in women with BRCA1-positive breast cancers. (PubMed id 17492376)1, 4, 9 Byrski T....Lubinski J. (2008)
    168. Higher occurrence of childhood cancer in families with germline mutations in BRCA2, MMR and CDKN2A genes. (PubMed id 18481196)1, 4, 9 Magnusson S....Olsson H. (2008)
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    174. No evidence that GATA3 rs570613 SNP modifies breast cancer risk. (PubMed id 19082709)1, 4, 9 Johnatty S.E....Chenevix-Trench G. (2008)
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    312. PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (2009)
    313. Survival in Norwegian BRCA1 mutation carriers with breast cancer. (PubMed id 19366445)1, 4 Hagen A.I....MA (2009)
    314. Pooled analysis indicates that the GSTT1 deletion, GS TM1 deletion, and GSTP1 Ile105Val polymorphisms do not modify breast cancer ris k in BRCA1 and BRCA2 mutation carriers. (PubMed id 19921428)1, 4 Spurdle A.B....McGuffog L. (2009)
    315. [Mutations in the BRCA1 gene (185delAG and 5382insC) are not present in any of the 30 breast cancer patients analyzed from eastern C olombia] (PubMed id 19753840)1, 4 Sanabria M.C....Vargas C.I. (2009)
    316. Advantages of the high resolution melting in the dete ction of BRCA1 or BRCA2 mutation carriers. (PubMed id 19616529)1, 4 JimAcnez I.d.e. .J....Bolufer Gilabert P. (2009)
    317. MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks. (PubMed id 19261746)1, 2 Shao G.... Greenberg R.A. (2009)
    318. BRCA1 breast cancer risk is modified by CYP19 polymorphisms in Ashkenazi Jews. (PubMed id 19366906)1, 4 Raskin L....Rennert G. (2009)
    319. The contribution of founder mutations to early-onset breast cancer in French-Canadian women. (PubMed id 19863560)1, 4 Ghadirian P....Foulkes W.D. (2009)
    320. Estimated risk of radiation-induced breast cancer from mammographic screening for young BRCA mutation carriers. (PubMed id 19176458)1, 4 Berrington de Gonzalez A....Robson M. (2009)
    321. Common Variants in Immune and DNA Repair Genes and Risk for Human Papillomavirus Persistence and Progression to Cervical Cancer. (PubMed id 19012493)1, 4 Wang S.S....Hildesheim A. (2009)
    322. Parity and the risk of breast and ovarian cancer in BRCA1 and BRCA2 mutation carriers. (PubMed id 19370414)1, 4 Milne R.L....BenA-tez J. (2009)
    323. Assessing the usefulness of a novel MRI-based breast density estimation algorithm in a cohort of women at high genetic risk of breas t cancer: the UK MARIBS study. (PubMed id 19903338)1, 4 Thompson D.J....Warren R.M. (2009)
    324. CASP8 D302H polymorphism delays the age of onset of breast cancer in BRCA1 and BRCA2 carriers. (PubMed id 19214744)1, 4 Palanca Suela S....Bolufer Gilabert P. (2009)
    325. Age-dependent penetrance of different germline mutations in the BRCA1 gene. (PubMed id 19329713)1, 4 Al-Mulla F....Taylor G.T. (2009)
    326. The TP53 Arg72Pro and MDM2 309G>T polymorphisms ar e not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers. (PubMed id 19707196)1, 4 Sinilnikova O.M....Stoppa-Lyonnet D. (2009)
    327. Clinical and pathologic differences between BRCA1-, B RCA2-, and non-BRCA-associated breast cancers in a multiracial developing count ry. (PubMed id 19649760)1, 4 Yip C.H....Teo S.H. (2009)
    328. Modification of ovarian cancer risk by BRCA1/2-intera cting genes in a multicenter cohort of BRCA1/2 mutation carriers. (PubMed id 19584272)1, 4 Rebbeck T.R....Chenevix-Trench G. (2009)
    329. A gene-based risk score for lung cancer susceptibilit y in smokers and ex-smokers. (PubMed id 19789190)1, 4 Young R.P....Gamble G.D. (2009)
    330. [Relationship between mutation of BRCA1 and susceptib ility to early onset of breast cancer] (PubMed id 19489266)1, 4 Meng J....Fu L. (2009)
    331. Ovarian epithelial dysplasia and prophylactic oophorectomy for genetic risk. (PubMed id 19258944)1, 4 ChA-ne G....Dauplat J. (2009)
    332. The BRCA1 3'-UTR: 5711+421T/T_5711+1286T/T genotype is a possible breast and ovarian cancer risk factor. (PubMed id 19405875)1, 4 Pongsavee M....Patmasiriwat P. (2009)
    333. Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk. (PubMed id 19690177)1, 4 McWilliams R.R....Petersen G.M. (2009)
    334. Two founder BRCA2 mutations predispose to breast canc er in young women. (PubMed id 19949853)1, 4 Infante M....Velasco E.A. (2009)
    335. Evaluation of a breast/ovarian cancer genetics referr al screening tool in a mammography population. (PubMed id 19752737)1, 4 Bellcross C.A....Meisner L.T. (2009)
    336. Molecular genetics analysis of hereditary breast and ovarian cancer patients in India. (PubMed id 19656415)1, 4 Soumittra N....Rajkumar T. (2009)
    337. Oral contraceptive use and BRCA penetrance: a case-on ly study. (PubMed id 19549808)1, 4 Pasanisi P....Berrino F. (2009)
    338. Genotyping of frequent BRCA1/2 SNPs with unlabeled pr obes: a supplement to HRMCA mutation scanning, allowing the strong reduction of sequencing burden. (PubMed id 19644020)1, 4 De Leeneer K....Claes K. (2009)
    339. Fertility in women with BRCA mutations: a case-control study. (PubMed id 19200971)1, 4 Pal T....Narod S.A. (2009)
    340. Genetic variation in immune regulation and DNA repair pathways and stomach cancer in China. (PubMed id 19661089)1, 4 Hussain S.K....Zhang Z.F. (2009)
    341. Elevated level of 8-oxo-7,8-dihydro-2'-deoxyguanosine in leukocytes of BRCA1 mutation carriers compared to healthy controls. (PubMed id 19623658)1, 4 Dziaman T....Olinski R. (2009)
    342. NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. (PubMed id 19261749)1, 2 Wang B.... Elledge S.J. (2009)
    343. [Detection of 5382insC mutation in human BRCA1 gene u sing fluorescent labeled oligonucleotides] (PubMed id 20088375)1, 4 Mitrofanov D.V....Liakhovich V.V. (2009)
    344. A polymorphism in Werner syndrome gene is associated with breast cancer susceptibility in Chinese women. (PubMed id 19205873)1, 4 Wang Z....Shen H. (2009)
    345. A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility. (PubMed id 19116388)1, 4 Vineis P....Matullo G. (2009)
    346. Role of BRCA2 mutation status on overall survival among breast cancer patients from Sardinia. (PubMed id 19232099)1, 4 Budroni M....Palmieri G. (2009)
    347. Functional polymorphisms in the BRCA1 promoter influence transcription and are associated with decreased risk for breast cancer in Chinese women. (PubMed id 18782836)1, 4 Chan K.Y....Khoo U.S. (2009)
    348. Mutational analysis of BRCA1 and BRCA2 genes in Mexic an breast cancer patients. (PubMed id 19899408)1, 4 Vidal-MillA!n S....DueA+as-GonzA!lez A. (2009)
    349. BRCA1 and BRCA2 germline mutations in Korean ovarian cancer patients. (PubMed id 19499246)1, 4 Lim M.C....Park S.Y. (2009)
    350. Breast cancer in young women (YBC): prevalence of BRC A1/2 mutations and risk of secondary malignancies across diverse racial groups. (PubMed id 19491284)1, 4 Haffty B.G....Moran M.S. (2009)
    351. The prevalence of BRCA1 mutations among young women with triple-negative breast cancer. (PubMed id 19298662)1, 4 Young S.R....Narod S.A. (2009)
    352. Explorative study to identify novel candidate genes r elated to oxaliplatin efficacy and toxicity using a DNA repair array. (PubMed id 19536092)1, 4 Kweekel D.M....Guchelaar H.J. (2009)
    353. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (2009)
    354. A method to assess the clinical significance of unclassified variants in the BRCA1 and BRCA2 genes based on cancer family history. (PubMed id 19200354)1, 4 GA^mez GarcA-a E.B....Vreeswijk M.P. (2009)
    355. Common genetic variants in candidate genes and risk o f familial lymphoid malignancies. (PubMed id 19573080)1, 4 Liang X.S....Goldin L.R. (2009)
    356. Diagnostic guidelines for high-resolution melting curve (HRM) analysis: An interlaboratory validation of BRCA1 mutation scanning using the 96-well LightScanner. (PubMed id 19370767)1, 4 van der Stoep N....Bakker E. (2009)
    357. Prevalence of BRCA1 and BRCA2 gene mutations in families with medium and high risk of breast and ovarian cancer in Brazil. (PubMed id 19377795)1, 4 Esteves V.F....Vieira R.J. (2009)
    358. MERIT40 facilitates BRCA1 localization and DNA damage repair. (PubMed id 19261748)1, 2 Feng L.... Chen J. (2009)
    359. Breast cancer risk in relation to the joint effect of BRCA mutations and diet diversity. (PubMed id 19165595)1, 4 Ghadirian P....Nkondjock A. (2009)
    360. Breast cancer susceptibility variants alter risks in familial disease. (PubMed id 19617217)1, 4 Latif A....Newman W.G. (2009)
    361. A role of BRCA1 and BRCA2 germline mutations in breas t cancer susceptibility within Sardinian population. (PubMed id 19619314)1, 4 Palomba G....Monne M. (2009)
    362. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)
    363. Fulfilling the promise of personalized medicine? Syst ematic review and field synopsis of pharmacogenetic studies. (PubMed id 19956635)1, 4 Holmes M.V....Casas J.P. (2009)
    364. Candidate serous cancer precursors in fallopian tube epithelium of BRCA1/2 mutation carriers. (PubMed id 19543244)1, 4 Shaw P.A....Begley H. (2009)
    365. Single nucleotide polymorphisms in miRNA binding site s and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk w omen. (PubMed id 19950226)1, 4 Kontorovich T....Friedman E. (2009)
    366. PALB2 is an integral component of the BRCA complex re quired for homologous recombination repair. (PubMed id 19369211)1, 2 Sy S.M....Chen J. (2009)
    367. Evaluation of a candidate breast cancer associated SN P in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results fro m the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA). (PubMed id 19920816)1, 4 Osorio A....Goldgar D. (2009)
    368. Familial Breast Cancer: Clinical Response to Induction Chemotherapy or Radiotherapy Related to BRCA1/2 Mutations Status. (PubMed id 19307946)1, 4 Fourquet A.... . (2009)
    369. Distant disease-free interval, site of first relapse and post-relapse survival in BRCA1- and BRCA2-associated compared to sporadic breast cancer patients. (PubMed id 17952592)1, 4 Kriege M....Klijn J.G. (2008)
    370. Smoking and the risk of breast cancer in BRCA1 and BRCA2 carriers: an update. (PubMed id 18483851)1, 4 Ginsburg O....Narod S.A. (2008)
    371. Polymorphisms in DNA repair genes, ionizing radiation exposure and risk of breast cancer in U.S. Radiologic technologists. (PubMed id 17764108)1, 4 Bhatti P....Sigurdson A.J. (2008)
    372. Asymmetric real-time PCR detection of BRCA1 5382insC mutation by melting curve analysis in the LightCycler. (PubMed id 18242166)1, 4 Kroupis C....Lianidou E.S. (2008)
    373. Evaluating the performance of models for predicting the BRCA germline mutations in Han Chinese familial breast cancer patients. (PubMed id 18807178)1, 4 Rao N.Y....Shao Z.M. (2008)
    374. Screening for ATM sequence alterations in African-American women diagnosed with breast cancer. (PubMed id 17333338)1, 4 Hirsch A.E....Rosenstein B.S. (2008)
    375. Polymorphisms in DNA repair and one-carbon metabolism genes and overall survival in diffuse large B-cell lymphoma and follicular lymphoma. (PubMed id 18830263)1, 4 Wang S.S....Cerhan J.R. (2008)
    376. Effect of BRCA1 haplotype on survival of non-small-cell lung cancer patients treated with platinum-based chemotherapy. (PubMed id 19018088)1, 4 Kim H.T....Ryu J.S. (2008)
    377. Contribution of BRCA1 germline mutation in patients with sporadic breast cancer. (PubMed id 18759965)1, 4 Malik F.A....Sadiq R. (2008)
    378. No evidence that CDKN1B (p27) polymorphisms modify breast cancer risk in BRCA1 and BRCA2 mutation carriers. (PubMed id 18543099)1, 4 Spurdle A.B....Chenevix-Trench G. (2008)
    379. Better life expectancy in women with BRCA2 compared with BRCA1 mutations is attributable to lower frequency and later onset of ovarian cancer. (PubMed id 18559571)1, 4 Byrd L.M....Evans G.D. (2008)
    380. BRCA1/BRCA2 mutation status and clinical-pathologic features of 108 male breast cancer cases from Tuscany: a population-based study in central Italy. (PubMed id 18819001)1, 4 Ottini L....Palli D. (2008)
    381. Prolactin levels, breast-feeding and milk production in a cohort of young healthy women from high-risk breast cancer families: implications for breast cancer risk. (PubMed id 18080788)1, 4 Hietala M....Jernstrom H. (2008)
    382. Effect of BRCA1/2 mutations on long-term survival of patients with invasive ovarian cancer: the national Israeli study of ovarian cancer. (PubMed id 18165636)1, 4 Chetrit A....Sadetzki S. (2008)
    383. Evaluation of unclassified variants in the breast cancer susceptibility genes BRCA1 and BRCA2 using five methods: results from a population-based study of young breast cancer patients. (PubMed id 18284688)1, 4 Lee E....Ursin G. (2008)
    384. The influence of genetic variation in 30 selected genes on the clinical characteristics of early onset breast cancer. (PubMed id 19094228)1, 4 Tapper W....Eccles D. (2008)
    385. Effect of reproductive factors and oral contraceptives on breast cancer risk in BRCA1/2 mutation carriers and noncarriers: results from a population-based study. (PubMed id 18990759)1, 4 Lee E....Ursin G. (2008)
    386. Evidence for an ancient BRCA1 mutation in breast cancer patients of yoruban ancestry. (PubMed id 18679828)1, 4 Zhang B....Olopade O.I. (2008)
    387. High risk for ovarian cancer in a prospective series is restricted to BRCA1/2 mutation carriers. (PubMed id 19010876)1, 4 Maehle L....Moller P. (2008)
    388. New sequence variants in BRCA1 and BRCA2 genes detected by high-resolution melting analysis in an elderly healthy female population in Croatia. (PubMed id 18844490)1, 4 Cvok M.L....Levanat S. (2008)
    389. Cross-sectional analysis of germline BRCA1 and BRCA2 mutations in Japanese patients suspected to have hereditary breast/ovarian cancer. (PubMed id 19016756)1, 4 Sugano K....Miki Y. (2008)
    390. Genetic contribution to all cancers: the first demonstration using the model of breast cancers from Poland stratified by age at diagnosis and tumour pathology. (PubMed id 18415014)1, 4 Lubinski J....Scott R. (2008)
    391. The relative contribution of point mutations and genomic rearrangements in BRCA1 and BRCA2 in high-risk breast cancer families. (PubMed id 18703817)1, 4 Palma M.D....Nathanson K.L. (2008)
    392. Early radiation exposures and BRCA1-associated breast cancer in young women from Poland. (PubMed id 18205043)1, 4 Gronwald J....Narod S.A. (2008)
    393. Greek BRCA1 and BRCA2 mutation spectrum: two BRCA1 mutations account for half the carriers found among high-risk breast/ovarian cancer patients. (PubMed id 17453335)1, 4 Konstantopoulou I....Yannoukakos D. (2008)
    394. Impaired tamoxifen metabolism reduces survival in familial breast cancer patients. (PubMed id 18794105)1, 4 Newman W.G....Evans D.G. (2008)
    395. A BRCA1 mutation is not associated with increased indicators of oxidative stress. (PubMed id 19073505)1, 4 Kotsopoulos J....Narod S.A. (2008)
    396. Absence of founder BRCA1 and BRCA2 mutations in coetaneous malignant melanoma patients of Ashkenazi origin. (PubMed id 18679827)1, 4 Kadouri L....Lotem M. (2008)
    397. High frequency of BRCA1/2 germline mutations in consecutive ovarian cancer patients in Poland. (PubMed id 17997147)1, 4 Brozek I....Limon J. (2008)
    398. Performance of BRCA1/2 mutation prediction models in Asian Americans. (PubMed id 18779604)1, 4 Kurian A.W....Ford J.M. (2008)
    399. Novel sequence variants and a high frequency of recurrent polymorphisms in BRCA1 gene in Sri Lankan breast cancer patients and at risk individuals. (PubMed id 18662409)1, 4 De Silva W....Ziard M.H. (2008)
    400. Disease family history and modification of breast cancer risk in common BRCA2 variants. (PubMed id 18288416)1, 4 Seymour I.J....Calistri D. (2008)
    401. Use of total abdominal hysterectomy and hormone replacement therapy in BRCA1 and BRCA2 mutation carriers undergoing risk-reducing salpingo-oophorectomy. (PubMed id 18758995)1, 4 Gabriel C.A....Domchek S.M. (2008)
    402. Spectrum and characterisation of BRCA1 and BRCA2 deleterious mutations in high-risk Czech patients with breast and/or ovarian cancer. (PubMed id 18489799)1, 4 Machackova E....Claes K. (2008)
    403. Power spectral analysis of mammographic parenchymal patterns for breast cancer risk assessment. (PubMed id 18175183)1, 4 Li H....Chinander M.R. (2008)
    404. Novel and common BRCA1 mutations in familial breast/ovarian cancer patients from Lithuania. (PubMed id 18763032)1, 4 Janavicius R....Kucinskas V. (2008)
    405. Pathogenicity of the BRCA1 missense variant M1775K is determined by the disruption of the BRCT phosphopeptide-binding pocket: a multi-modal approach. (PubMed id 18285836)1, 2 Tischkowitz M....Foulkes W.D. (2008)
    406. RASSF1A polymorphism A133S is associated with early onset breast cancer in BRCA1/2 mutation carriers. (PubMed id 18172292)1, 4 Gao B....Minna J.D. (2008)
    407. Infertility, treatment of infertility, and the risk of breast cancer among women with BRCA1 and BRCA2 mutations: a case-control study. (PubMed id 18509731)1, 4 Kotsopoulos J....Narod S.A. (2008)
    408. No association of TGFB1 L10P genotypes and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a multi-center cohort study. (PubMed id 18523885)1, 4 Rebbeck T.R....Easton D.F. (2008)
    409. [BRCA1/2 gene mutation in Chinese familial breast cancer patients: a multi-center report of 115 cases] (PubMed id 19087709)1, 4 Hu Z....Shao Z.M. (2008)
    410. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)1, 4 Palmieri R.T.... . (2008)
    411. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (2008)
    412. CHEK2*1100delC genotyping for clinical assessment of breast cancer risk: meta-analyses of 26,000 patient cases and 27,000 controls. (PubMed id 18172190)1, 4 Weischer M....Nordestgaard B.G. (2008)
    413. Methionine-dependence phenotype in the de novo pathway in BRCA1 and BRCA2 mutation carriers with and without breast cancer. (PubMed id 18842997)1, 4 Beetstra S....Fenech M. (2008)
    414. Histopathological findings and follow-up after prophylactic mastectomy and immediate breast reconstruction in 100 women from families with hereditary breast cancer. (PubMed id 18434071)1, 4 Isern A.E....Ringberg A. (2008)
    415. Pleomorphic adenoma of salivary glands does not appear to be a BRCA-1-dependent tumour in a Polish cohort. (PubMed id 19031948)1, 4 Lubinski J....Lubinski J. (2008)
    416. MLPA screening in the BRCA1 gene from 1,506 German hereditary breast cancer cases: novel deletions, frequent involvement of exon 17, and occurrence in single early-onset cases. (PubMed id 18431737)1, 4 Engert S....Meindl A. (2008)
    417. Ovarian cancer risk in Polish BRCA1 mutation carriers is not associated with the prohibitin 3' untranslated region polymorphism. (PubMed id 18397521)1, 4 Jakubowska A....Hamann U. (2008)
    418. 'BRCAness' syndrome in ovarian cancer: a case-control study describing the clinical features and outcome of patients with epithelial ovarian cancer associated with BRCA1 and BRCA2 mutations. (PubMed id 18955455)1, 4 Tan D.S....Gore M.E. (2008)
    419. Screening for Familial Ovarian Cancer: Poor survival of BRCA1/2 related cancers. (PubMed id 18413372)1, 4 Evans G.R....Moller P. (2008)
    420. Smoking and risk of breast cancer in carriers of mutations in BRCA1 or BRCA2 aged less than 50 years. (PubMed id 17972172)1, 4  . and . (2008)
    421. Pathway analysis of single-nucleotide polymorphisms potentially associated with glioblastoma multiforme susceptibility using random forests. (PubMed id 18559551)1, 4 Chang J.S....Wrensch M.R. (2008)
    422. High-resolution melting analysis for rapid screening of BRCA1 and BRCA2 Spanish mutations. (PubMed id 18528753)1, 4 de Juan I....Bolufer P. (2008)
    423. Predictive genetic testing for BRCA1/2 in a UK clinical cohort: three-year follow-up. (PubMed id 17285126)1, 4 Foster C....Evans D.G. (2007)
    424. CCDC98 targets BRCA1 to DNA damage sites. (PubMed id 17643121)1, 2 Liu Z.... Yu X. (2007)
    425. [5589del8: the recurrent mutation of BRCA1 gene in Chinese breast cancer patients] (PubMed id 17680524)1, 4 Hu Z....Shao Z.M. (2007)
    426. Clinical outcomes of breast cancer in carriers of BRCA1 and BRCA2 mutations. (PubMed id 17625123)1, 4 Rennert G....Narod S.A. (2007)
    427. Absence of the common IGF1 19 CA-repeat allele is more common among BRCA1 mutation carriers than among non-carriers from BRCA1 families. (PubMed id 17484040)1, 4 Henningson M....Jernstrom H. (2007)
    428. Founder mutations in early-onset, familial and bilateral breast cancer patients from Russia. (PubMed id 17333477)1, 4 Sokolenko A.P....Imyanitov E.N. (2007)
    429. Meta-analysis of BRCA1 and BRCA2 penetrance. (PubMed id 17416853)1, 4 Chen S. and Parmigiani G. (2007)
    430. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)1, 2 Matsuoka S.... Elledge S.J. (2007)
    431. A systematic genetic assessment of 1,433 sequence variants of unknown clinical significance in the BRCA1 and BRCA2 breast cancer-predisposition genes. (PubMed id 17924331)1, 2 Easton D.F....Goldgar D.E. (2007)
    432. 655Val and 1170Pro ERBB2 SNPs in familial breast cancer risk and BRCA1 alterations. (PubMed id 17452776)1, 4 Tommasi S....Paradiso A. (2007)
    433. Multiplex SNaPshot for detection of BRCA1/2 common mutations in Spanish and Spanish related breast/ovarian cancer families. (PubMed id 17603881)1, 4 Filippini S....Vega A. (2007)
    434. Lymphocyte radiosensitivity in BRCA1 and BRCA2 mutation carriers and implications for breast cancer susceptibility. (PubMed id 17582599)1, 4 Barwell J....Hodgson S.V. (2007)
    435. Polymorphism in nucleotide excision repair gene XPC correlates with bleomycin-induced chromosomal aberrations. (PubMed id 17685459)1, 4 Laczmanska I....Sasiadek M.M. (2007)
    436. Prognosis of early-onset breast cancer based on BRCA1/2 mutation status in a French population-based cohort and review. (PubMed id 17061047)1, 4 Bonadona V....Lasset C. (2007)
    437. This article was published online in error and has been removed by the publisher. (PubMed id 17409195)1, 4 (2007)
    438. Methyl group metabolism gene polymorphisms as modifier of breast cancer risk in Italian BRCA1/2 carriers. (PubMed id 17151928)1, 4 Pepe C....Caligo M.A. (2007)
    439. CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response. (PubMed id 17643122)1, 2 Kim H.... Chen J. (2007)
    440. BRCA1 disease-associated haplotypes in Singapore Malay women with early-onset breast/ovarian cancer. (PubMed id 17406974)1, 4 Ali A.B....Sng J.H. (2007)
    441. [Several risk factors of breast cancer development and prognosis of its course] (PubMed id 18663943)1, 4 Dovzhenko S.P....Gorovenko N.G. (2007)
    442. High prevalence of BRCA1 deletions in BRCAPRO-positive patients with high carrier probability. (PubMed id 17591842)1, 4 Veschi S....Stuppia L. (2007)
    443. BRCA mutations in women with ductal carcinoma in situ. (PubMed id 17634561)1, 4 Smith K.L....Robson M. (2007)
    444. Prediction of BRCA1/2 mutation status in patients with ovarian cancer from a hospital-based cohort. (PubMed id 17413421)1, 4 Jacobi C.E....Kenter G.G. (2007)
    445. The impact of BRCA1 on spina bifida meningomyelocele lesions. (PubMed id 17640328)1, 4 King T.M....Northrup H. (2007)
    446. Results of a population-based screening for hereditary breast cancer in a region of North-Central Italy: contribution of BRCA1/2 germ-line mutations. (PubMed id 18092194)1, 4 Seymour I.J....Calistri D. (2007)
    447. CYP17 genotype is associated with short menstrual cycles, early oral contraceptive use and BRCA mutation status in young healthy women. (PubMed id 17307805)1, 4 Henningson M....Jernstrom H. (2007)
    448. AURKA F31I polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a consortium of investigators of modifiers of BRCA1/2 study. (PubMed id 17627006)1, 4 Couch F.J....Antoniou A.C. (2007)
    449. Prevalence of pathogenic BRCA1 mutation carriers in 5 US racial/ethnic groups. (PubMed id 18159056)1, 4 John E.M....Whittemore A.S. (2007)
    450. BRCA1 and BRCA2 germline mutations in Korean breast cancer patients at high risk of carrying mutations. (PubMed id 16455195)1, 4 Ahn S.H....Cho D.Y. (2007)
    451. [Study of BRCA1 and BRCA2 gene mutations in human sporadic breast cancers] (PubMed id 17686308)1, 4 Zhang H.T....Wan F.Q. (2007)
    452. Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers. (PubMed id 18095154)1, 4 Walker L.C....Spurdle A.B. (2007)
    453. MDM2 SNP309 accelerates breast and ovarian carcinogenesis in BRCA1 and BRCA2 carriers of Jewish-Ashkenazi descent. (PubMed id 18026875)1, 4 Yarden R.I....Papa M.Z. (2007)
    454. BRCA1 and BRCA2 genetic testing in Hispanic patients: mutation prevalence and evaluation of the BRCAPRO risk assessment model. (PubMed id 17925560)1, 4 Vogel K.J....Arun B. (2007)
    455. Improved survival in BRCA2 carriers with ovarian cancer. (PubMed id 17160431)1, 4 Pal T....Sutphen R. (2007)
    456. BRCA1 and BRCA2 germline mutation analysis in the Indonesian population. (PubMed id 17972177)1, 4 Purnomosari D....van Diest P.J. (2007)
    457. High incidence of mutations in BRCA1 and BRCA2 genes in ovarian cancer. (PubMed id 18256760)1, 4 Smirnova T.Y....Karpukhin A.V. (2007)
    458. Germline mutations in the breast cancer susceptibility gene PTEN are rare in high-risk non-BRCA1/2 French Canadian breast cancer families. (PubMed id 17636424)1, 4 Guenard F....Durocher F. (2007)
    459. BRCA1 genetic testing in 106 breast and ovarian cancer families from Southern Italy (Sicily): a mutation analyses. (PubMed id 17221156)1, 4 Russo A....Bazan V. (2007)
    460. Differences in the frequency and distribution of BRCA1 and BRCA2 mutations in breast/ovarian cancer cases from the Basque country with respect to the Spanish population: implications for genetic counselling. (PubMed id 17262179)1, 4 Beristain E....Tejada M.I. (2007)
    461. Ductal carcinoma in situ in BRCA mutation carriers. (PubMed id 17210933)1, 4 Hwang E.S....Ziegler J.L. (2007)
    462. Oral contraceptives and breast cancer risk in the international BRCA1/2 carrier cohort study: a report from EMBRACE, GENEPSO, GEO-HEBON, and the IBCCS Collaborating Group. (PubMed id 17635951)1, 4 Brohet R.M....Rookus M.A. (2007)
    463. Acute chemotherapy-related toxicity is not increased in BRCA1 and BRCA2 mutation carriers treated for breast cancer in the United Kingdom. (PubMed id 17145825)1, 4 Shanley S....Eeles R. (2006)
    464. Insulin-like growth factor-1 genotype predicts breast volume after pregnancy and hormonal contraception and is associated with circulating insulin-like growth factor-1 levels: implications for risk of early-onset breast cancer in young women from hereditary breast cancer families. (PubMed id 17010055)1, 4 Jernstrom H....Olsson H. (2006)
    465. Are CYP17 genotypes a biomarker for ovarian cancer in patients with cancer history in their family? (PubMed id 16783967)1, 4 Yazici H....Dalay N. (2006)
    466. Prevalence and predictors of BRCA1 and BRCA2 mutations in a population-based study of breast cancer in white and black American women ages 35 to 64 years. (PubMed id 16912212)1, 4 Malone K.E....Ostrander E.A. (2006)
    467. Pregnancies, breast-feeding, and breast cancer risk in the International BRCA1/2 Carrier Cohort Study (IBCCS). (PubMed id 16622123)1, 4 Andrieu N.... . (2006)
    468. Racial differences in the incidence of BRCA1 and BRCA2 mutations in a cohort of early onset breast cancer patients: African American compared to white women. (PubMed id 15983021)1, 4 Haffty B.G....Lannin D. (2006)
    469. High frequency of BRCA1 5382insC mutation in Russian breast cancer patients. (PubMed id 16737811)1, 4 Sokolenko A.P....Imyanitov E.N. (2006)
    470. BRCA1-positive breast cancers in young women from Poland. (PubMed id 16541315)1, 4 Lubinski J....Narod S.A. (2006)
    471. Diet, lifestyle and BRCA-related breast cancer risk among French-Canadians. (PubMed id 16541324)1, 4 Nkondjock A....Ghadirian P. (2006)
    472. Mutation analysis of BRCA1 and BRCA2 from 793 Korean patients with sporadic breast cancer. (PubMed id 17100994)1, 4 Han S.H....Chung W.S. (2006)
    473. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    474. Hormone replacement therapy and the risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers. (PubMed id 16137751)1, 4 Kotsopoulos J....Narod S.A. (2006)
    475. Low prevalence of BRCA1 exon rearrangements in familial and young sporadic breast cancer patients. (PubMed id 16724249)1, 4 Ellis D....Abbs S.J. (2006)
    476. Screening mammography and risk of breast cancer in BRCA1 and BRCA2 mutation carriers: a case-control study. (PubMed id 16648044)1, 4 Narod S.A....Sun P. (2006)
    477. Childhood cancer in families with and without BRCA1 or BRCA2 mutations ascertained at a high-risk breast cancer clinic. (PubMed id 16931905)1, 4 Brooks G.A....Domchek S.M. (2006)
    478. Characterization of BRCA1 and BRCA2 mutations in a large United States sample. (PubMed id 16484695)1, 4 Chen S....Parmigiani G. (2006)
    479. Influence of the MDM2 single nucleotide polymorphism SNP309 on tumour development in BRCA1 mutation carriers. (PubMed id 16563154)1, 4 Copson E.R....Eccles D.M. (2006)
    480. BRCA1 and BRCA2 mutation carriers, oral contraceptive use, and breast cancer before age 50. (PubMed id 17021353)1, 4 Haile R.W....Whittemore A.S. (2006)
    481. BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP. (PubMed id 16818604)1, 2 Yu X....Chen J. (2006)
    482. Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma among women in Connecticut. (PubMed id 16738949)1, 4 Shen M....Rothman N. (2006)
    483. Coffee consumption and breast cancer risk among BRCA1 and BRCA2 mutation carriers. (PubMed id 16032702)1, 4 Nkondjock A....Narod S.A. (2006)
    484. [Prevalence of Val158Met polymorphism in COMT gene on non-BRCA1/2 hereditary breast cancer] (PubMed id 17217814)1, 4 Song C.G....Shao Z.M. (2006)
    485. Late toxicity is not increased in BRCA1/BRCA2 mutation carriers undergoing breast radiotherapy in the United Kingdom. (PubMed id 17145824)1, 4 Shanley S....Eeles R. (2006)
    486. ACCA phosphopeptide recognition by the BRCT repeats of BRCA1. (PubMed id 16698035)1, 2 Ray H.... Venezia N.D. (2006)
    487. Search for large genomic alterations of the BRCA1 gene in a Finnish population. (PubMed id 16271956)1, 4 Laurila E....Karhu R. (2005)
    488. Effect of pregnancy as a risk factor for breast cancer in BRCA1/BRCA2 mutation carriers. (PubMed id 15986445)1, 4 Cullinane C.A....Narod S.A. (2005)
    489. The Tyr978X BRCA1 mutation: occurrence in non-Jewish Iranians and haplotype in French-Canadian and non-Ashkenazi Jews. (PubMed id 15951957)1, 4 Quintana-Murci L....Friedman E. (2005)
    490. Impact of teenage oral contraceptive use in a population-based series of early-onset breast cancer cases who have undergone BRCA mutation testing. (PubMed id 16118051)1, 4 Jernstrom H....Olsson H. (2005)
    491. Hereditary breast cancer growth rates and its impact on screening policy. (PubMed id 15978801)1, 4 Tilanus-Linthorst M.M....Brekelmans C.T. (2005)
    492. Mutational analysis of the BRCA1 gene in 30 Czech ovarian cancer patients. (PubMed id 15876585)1, 4 Zikan M....Stribrna J. (2005)
    493. Changes in body weight and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. (PubMed id 16168130)1, 4 Kotsopoulos J....Narod S.A. (2005)
    494. Prevalence of BRCA mutations and founder effect in high-risk Hispanic families. (PubMed id 16030099)1, 4 Weitzel J.N....Neuhausen S. (2005)
    495. High prevalence of two BRCA1 mutations, 4154delA and 5382insC, in Latvia. (PubMed id 15951956)1, 4 Tikhomirova L....Stengrevics A. (2005)
    496. Contribution of BRCA1 and BRCA2 germ-line mutations to the incidence of breast cancer in young women: results from a prospective population-based study in France. (PubMed id 15887246)1, 4 Bonadona V....Lasset C. (2005)
    497. Prevalence of five previously reported and recurrent BRCA1 genetic rearrangement mutations in 20,000 patients from hereditary breast/ovarian cancer families. (PubMed id 15846789)1, 4 Hendrickson B.C....Scholl T. (2005)
    498. Placental cadherin and the basal epithelial phenotype of BRCA1-related breast cancer. (PubMed id 15930334)1, 4 Arnes J.B....Foulkes W.D. (2005)
    499. Familial breast cancer: characteristics and outcome of BRCA 1-2 positive and negative cases. (PubMed id 15996267)1, 4 Veronesi A....Boiocchi M. (2005)
    500. Patients with an unclassified genetic variant in the BRCA1 or BRCA2 genes show different clinical features from those with a mutation. (PubMed id 15800311)1, 4 Gomez-Garcia E.B....van den Wijngaard A. (2005)
    501. Haplotype analysis of common variants in the BRCA1 gene and risk of sporadic breast cancer. (PubMed id 15743496)1, 4 Cox D.G....Hunter D.J. (2005)
    502. A haplotype-based case-control study of BRCA1 and sporadic breast cancer risk. (PubMed id 16103107)1, 4 Freedman M.L....Haiman C.A. (2005)
    503. Prevalence and clinical correlations of BRCA1/BRCA2 unclassified variant carriers among unselected primary ovarian cancer cases - preliminary report. (PubMed id 15617999)1, 4 Majdak E.J....Devilee P. (2005)
    504. Risk of breast cancer recurrence and contralateral breast cancer in relation to BRCA1 and BRCA2 mutation status following breast-conserving surgery and radiotherapy. (PubMed id 16140006)1, 4 Kirova Y.M....Fourquet A. (2005)
    505. Age at menarche and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. (PubMed id 16049805)1, 4 Kotsopoulos J....Narod S.A. (2005)
    506. Breast and ovarian cancer risks to carriers of the BRCA1 5382insC and 185delAG and BRCA2 6174delT mutations: a combined analysis of 22 population based studies. (PubMed id 15994883)1, 4 Antoniou A.C....Easton D.F. (2005)
    507. Incidence of BRCA1 and BRCA2 mutations in young Korean breast cancer patients. (PubMed id 15117986)1, 4 Choi D.H....Haffty B.G. (2004)
    508. Prevalence of BRCA1 mutation carriers among U.S. non-Hispanic Whites. (PubMed id 15598764)1, 4 Whittemore A.S....West D.W. (2004)
    509. Predictors of cognitive appraisals following genetic testing for BRCA1 and BRCA2 mutations. (PubMed id 15559734)1, 4 Halbert C.H....Lerman C. (2004)
    510. Awareness of breast cancer genetics and interest in predictive genetic testing: a survey of a southern Italian population. (PubMed id 15280188)1, 4 Bruno M....Paradiso A. (2004)
    511. High-throughput association testing on DNA pools to identify genetic variants that confer susceptibility to acute myeloid leukemia. (PubMed id 15159312)1, 4 Rollinson S....Morgan G.J. (2004)
    512. Cytoplasmic mislocalization of BRCA1 caused by cancer-associated mutations in the BRCT domain. (PubMed id 14729053)1, 4 Rodriguez J.A....Henderson B.R. (2004)
    513. Relation of contraceptive and reproductive history to ovarian cancer risk in carriers and noncarriers of BRCA1 gene mutations. (PubMed id 15383404)1, 4 McGuire V....Whittemore A.S. (2004)
    514. Frequency of the ATM IVS10-6T-->G variant in Australian multiple-case breast cancer families. (PubMed id 15217508)1, 4 Lindeman G.J....Kirk J. (2004)
    515. The 1100delAT BRCA1 and the 8765delAG BRCA2 mutations: occurrence in high-risk non-Ashkenazi Jews and haplotype comparison of Jewish and non-Jewish carriers. (PubMed id 15131400)1, 4 Gal I....Friedman E. (2004)
    516. Loss of heterozygosity in normal breast epithelial tissue and benign breast lesions in BRCA1/2 carriers with breast cancer. (PubMed id 15104281)1, 4 Cavalli L.R....Haddad B.R. (2004)
    517. Impact of BRCA1/BRCA2 counseling and testing on newly diagnosed breast cancer patients. (PubMed id 15067026)1, 4 Schwartz M.D....Isaacs C. (2004)
    518. Clinical features of familial ovarian cancer lacking mutations in BRCA1 or BRCA2. (PubMed id 15053073)1, 4 Menkiszak J....Lubinski J. (2004)
    519. BRCA1 and BRCA2 germline mutation spectrum and frequencies in Belgian breast/ovarian cancer families. (PubMed id 15026808)1, 2 Claes K.... Messiaen L. (2004)
    520. Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response. (PubMed id 15456891)1, 2 Zhang X....Legerski R.J. (2004)
    521. Impact of BRCA1/2 testing and disclosure of a positive test result on women affected and unaffected with breast or ovarian cancer. (PubMed id 14735581)1, 4 van Roosmalen M.S....van Daal W.A. (2004)
    522. Cancer genetics knowledge and beliefs and receipt of results in Ashkenazi Jewish individuals receiving counseling for BRCA1/2 mutations. (PubMed id 15284715)1, 4 Kelly K....Schwalb M. (2004)
    523. Efficacy of risk-reducing salpingo-oophorectomy in women with BRCA-1 and BRCA-2 mutations. (PubMed id 14984481)1, 4 Olopade O.I. and Artioli G. (2004)
    524. A gene-environment interaction between occupation and BRCA1/BRCA2 mutations in male breast cancer? (PubMed id 15519522)1, 4 Palli D....Ottini L. (2004)
    525. The presence of hereditary BRCA1 gene mutations in women with familial breast or ovarian cancer and the frequency of occurrence of these tumours in their relatives. (PubMed id 15285306)1, 4 Skasko E....Pienkowski T. (2004)
    526. Non-uptake of predictive genetic testing for BRCA1/2 among relatives of known carriers: attributes, cancer worry, and barriers to testing in a multicenter clinical cohort. (PubMed id 15140371)1, 4 Foster C....Watson M. (2004)
    527. Human claspin works with BRCA1 to both positively and negatively regulate cell proliferation. (PubMed id 15096610)1, 2 Lin S.-Y.... Elledge S.J. (2004)
    528. Surveillance of BRCA1 and BRCA2 mutation carriers with magnetic resonance imaging, ultrasound, mammography, and clinical breast examination. (PubMed id 15367553)1, 4 Warner E....Narod S.A. (2004)
    529. Accommodating risk: responses to BRCA1/2 genetic testing of women who have had cancer. (PubMed id 15144764)1, 4 Hallowell N....Watson M. (2004)
    530. Randomised trial of a decision aid and its timing for women being tested for a BRCA1/2 mutation. (PubMed id 14735173)1, 4 van Roosmalen M.S....van Daal W.A. (2004)
    531. BRCA1 and sex ratio. (PubMed id 15114373)1, 4 Struewing J.P....Greene M.H. (2004)
    532. Predictors of participation in psychosocial telephone counseling following genetic testing for BRCA1 and BRCA2 mutations. (PubMed id 15159322)1, 4 Halbert C.H....Bellamy S. (2004)
    533. Association of NQO1 polymorphism with spontaneous breast cancer in two independent populations. (PubMed id 15138483)1, 4 Menzel H.J....Kraft H.G. (2004)
    534. Estrogen receptor status in BRCA1- and BRCA2-related breast cancer: the influence of age, grade, and histological type. (PubMed id 15041722)1, 4 Foulkes W.D....Narod S.A. (2004)
    535. An audit of screening for familial breast cancer before 50 years in the South Thames Region - have we got it right? (PubMed id 15131403)1, 4 Murday V....Hodgson S. (2004)
    536. Survival and recurrence after breast cancer in BRCA1/2 mutation carriers. (PubMed id 14761918)1, 4 El-Tamer M....Mansukhani M. (2004)
    537. Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer. (PubMed id 15133502)1, 2 Clapperton J.A....Smerdon S.J. (2004)
    538. Screening adherence in BRCA1/2 families is associated with primary physicians' behavior. (PubMed id 14755459)1, 4 Tinley S.T....Lynch H.T. (2004)
    539. Analyses of p53 expression pattern and BRCA mutations in patients with double primary breast and ovarian cancer. (PubMed id 15086724)1, 4 Bruchim I....Kopolovic J. (2004)
    540. [Analysis of BRCA1 mutations in Chinese patients with early onset breast cancer and affected relatives.] (PubMed id 15777502)1, 4 Hu Z....Shao Z.M. (2004)
    541. Diagnostic genetic testing for hereditary breast and ovarian cancer in cancer patients: women's looking back on the pre-test period and a psychological evaluation. (PubMed id 15140370)1, 4 Claes E....Legius E. (2004)
    542. Prevalence of BRCA1 and BRCA2 mutations in Korean breast cancer patients. (PubMed id 15082902)1, 4 Ahn S.H....Son B.H. (2004)
    543. Ovarian cancer and polymorphisms in the androgen and progesterone receptor genes: a HuGE review. (PubMed id 14769635)1, 4 Modugno F. (2004)
    544. Effect of a computer-based decision aid on knowledge, perceptions, and intentions about genetic testing for breast cancer susceptibility: a randomized controlled trial. (PubMed id 15280342)1, 4 Green M.J....Mauger D.T. (2004)
    545. BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition. (PubMed id 14990569)1, 2 Ouchi M.... Ouchi T. (2004)
    546. ERBB2, TBX2, RPS6KB1, and MYC alterations in breast tissues of BRCA1 and BRCA2 mutation carriers. (PubMed id 15236312)1, 4 Adem C....Jenkins R.B. (2004)
    547. Offspring gender ratio and the rate of recurrent spontaneous miscarriages in jewish women at high risk for breast/ovarian cancer. (PubMed id 15116316)1, 4 Gal I....Friedman E. (2004)
    548. Smoking and the risk of breast cancer among carriers of BRCA mutations. (PubMed id 15095307)1, 4 Ghadirian P....Narod S.A. (2004)
    549. Defect of tumour necrosis factor-alpha (TNF-alpha) production and TNF-alpha-induced ICAM-1-expression in BRCA1 mutations carriers. (PubMed id 14572152)1, 4 Zielinski C.C....Wiltschke C. (2003)
    550. Long-term psychological impact of carrying a BRCA1/2 mutation and prophylactic surgery: a 5-year follow-up study. (PubMed id 14551306)1, 4 van Oostrom I....Tibben A. (2003)
    551. Life insurance and breast cancer risk assessment: adverse selection, genetic testing decisions, and discrimination. (PubMed id 12838555)1, 4 Armstrong K....Asch D.A. (2003)
    552. BRCA1/2 mutation carriers: living with susceptibility. (PubMed id 15331870)1, 4 Hagoel L....Rennert G. (2003)
    553. The analysis of BRCA1 mutations in eastern Chinese patients with early onset breast cancer and affected relatives. (PubMed id 12815604)1, 4 Hu Z....Shao Z.M. (2003)
    554. Improved survival in women with BRCA-associated ovarian carcinoma. (PubMed id 12712470)1, 4 Cass I....Karlan B.Y. (2003)
    555. BRCA1 and BRCA2 mutation status and tumor characteristics in male breast cancer: a population-based study in Italy. (PubMed id 12543786)1, 4 Ottini L....Palli D. (2003)
    556. Characterization of 458 single nucleotide polymorphisms of disease candidate genes in the Korean population. (PubMed id 12768436)1, 4 Lee J.K....Jo I. (2003)
    557. Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2. (PubMed id 14576434)1, 4 King M.C....Mandell J.B. (2003)
    558. Awareness and concern about ovarian cancer among women at risk because of a family history of breast or ovarian cancer. (PubMed id 14586320)1, 4 Andersen M.R....McTiernan A. (2003)
    559. Germline mutations in the BRCA1 and BRCA2 genes in Turkish breast/ovarian cancer patients. (PubMed id 12655560)1, 4 Manguoglu A.E....Friedman E. (2003)
    560. Structural consequences of a cancer-causing BRCA1-BRCT missense mutation. (PubMed id 12427738)1, 2 Williams R.S. and Glover J.N. (2003)
    561. Frequency of BRCA mutations in primary peritoneal carcinoma in Israeli Jewish women. (PubMed id 12504628)1, 4 Menczer J....Modan B. (2003)
    562. Twenty-three novel BRCA1 and BRCA2 sequence alterations in breast and/or ovarian cancer families in Southern Germany. (PubMed id 12938098)1, 2 Meyer P.... Klaes R. (2003)
    563. P53 codon 72 polymorphism and BRCA 1 and 2 mutations in ovarian epithelial malignancies in black South Africans. (PubMed id 12911720)1, 4 Pegoraro R.J....Moodley J. (2003)
    564. Polymorphisms in BRCA1 and BRCA2 and risk of epithelial ovarian cancer. (PubMed id 14555511)1, 4 Wenham R.M....Berchuck A. (2003)
    565. Familial risks, early-onset breast cancer, and BRCA1 and BRCA2 germline mutations. (PubMed id 12644538)1, 4 Dite G.S....Hopper J.L. (2003)
    566. Prevalence of BRCA1 and BRCA2 germline mutations in young breast cancer patients: a population-based study. (PubMed id 12845657)1, 4 de Sanjose S....Sinilnikova O.M. (2003)
    567. Reproductive factors and ovarian cancer risk in Jewish BRCA1 and BRCA2 mutation carriers (United States). (PubMed id 12946038)1, 4 Modugno F....Narod S.A. (2003)
    568. Bilateral prophylactic oophorectomy and ovarian cancer screening following BRCA1/BRCA2 mutation testing. (PubMed id 14581427)1, 4 Schwartz M.D....Lerman C. (2003)
    569. Communication of BRCA1 and BRCA2 results to at-risk relatives: a cancer risk assessment program's experience. (PubMed id 12704633)1, 4 Wagner Costalas J....Daly M.B. (2003)
    570. Effect of genetic cancer risk assessment on surgical decisions at breast cancer diagnosis. (PubMed id 14662532)1, 4 Weitzel J.N....Cullinane C.A. (2003)
    571. Population attributes affecting the prevalence of BRCA mutation carriers in epithelial ovarian cancer cases in israel. (PubMed id 12798717)1, 4 Hirsh-Yechezkel G....Modan B. (2003)
    572. Log odds of carrying an Ancestral Mutation in BRCA1 or BRCA2 for a Defined personal and family history in an Ashkenazi Jewish woman (LAMBDA). (PubMed id 14580256)1, 4 Apicella C....Hopper J.L. (2003)
    573. Communication with close and distant relatives in the context of genetic testing for hereditary breast and ovarian cancer in cancer patients. (PubMed id 12476445)1, 4 Claes E....Legius E. (2003)
    574. Mutational analysis of BRCA1 and BRCA2 in Mediterranean Spanish women with early-onset breast cancer: identification of three novel pathogenic mutations. (PubMed id 14517958)1, 4 Martinez-Ferrandis J.I....Armengod M.E. (2003)
    575. Family history of breast and ovarian cancer and the r isk of breast carcinoma in situ. (PubMed id 12611452)1, 4 Claus E.B....Carter D. (2003)
    576. Mutational screening of breast cancer susceptibility gene 1 from early onset, bi-lateral, and familial breast cancer patients in Taiwan. (PubMed id 12602912)1, 4 Chen S.T....Chien Y.C. (2003)
    577. Gynecologic surgeries and risk of ovarian cancer in women with BRCA1 and BRCA2 Ashkenazi founder mutations: an Israeli population-based case-control study. (PubMed id 12865453)1, 4 Rutter J.L....Hartge P. (2003)
    578. Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies. (PubMed id 12677558)1, 4 Antoniou A....Easton D.F. (2003)
    579. BRCA1 and BRCA2 germline mutations in lymphoma patients. (PubMed id 12691152)1, 4 Yossepowitch O....Offit K. (2003)
    580. Sociocultural influences on participation in genetic risk assessment and testing among African American women. (PubMed id 14572939)1, 4 Hughes C....Finch C. (2003)
    581. Balancing autonomy and responsibility: the ethics of generating and disclosing genetic information. (PubMed id 12672886)1, 4 Hallowell N....Watson M. (2003)
    582. Early use of clinical BRCA1/2 testing: associations with race and breast cancer risk. (PubMed id 12567413)1, 4 Armstrong K....Schwartz J.S. (2003)
    583. Attitudes, knowledge, risk perceptions and decision-making among women with breast and/or ovarian cancer considering testing for BRCA1 and BRCA2 and their spouses. (PubMed id 12833555)1, 4 Bluman L.G....Winer E.P. (2003)
    584. Rad52 gene mutations in breast/ovarian cancer families and sporadic ovarian carcinoma patients. (PubMed id 12883740)1, 4 Tong D....Zeillinger R. (2003)
    585. Fallopian tube and primary peritoneal carcinomas associated with BRCA mutations. (PubMed id 14615451)1, 4 Levine D.A....Boyd J. (2003)
    586. Cancer incidence in relatives of a population-based set of cases of early-onset breast cancer with a known BRCA1 and BRCA2 mutation status. (PubMed id 14580253)1, 4 Loman N....Olsson H. (2003)
    587. BRCA1 and BRCA2 sequence variants in Chinese breast cancer families. (PubMed id 12442274)1, 2 Zhi X.... Shi Y.-R. (2002)
    588. BRCA1 and BRCA2 mutations in breast cancer patients from Saudi Arabia. (PubMed id 12070551)1, 4 El-Harith e.l.-.H.A....Dork T. (2002)
    589. BRCA1 and BRCA2 mutations among breast cancer patients from the Philippines. (PubMed id 11920621)1, 4 De Leon Matsuda M.L....Narod S.A. (2002)
    590. Anticipation in hereditary breast cancer. (PubMed id 12220452)1, 4 Dagan E. and Gershoni-Baruch R. (2002)
    591. Recurrent BRCA1 and BRCA2 germline mutations in ovarian cancer: a founder mutation of BRCA1 identified in the Chinese population. (PubMed id 11857749)1, 4 Khoo U.S....Ozcelik H. (2002)
    592. Androgen receptor CAG repeat length in Jewish Israeli women who are BRCA1/2 mutation carriers: association with breast/ovarian cancer phenotype. (PubMed id 12404104)1, 4 Dagan E....Gershoni-Baruch R. (2002)
    593. The BRCA2 372 HH genotype is associated with risk of breast cancer in Australian women under age 60 years. (PubMed id 11927503)1, 4 Spurdle A.B....Chenevix-Trench G. (2002)
    594. [Analysis of mutation sites of BRCA1 gene in Chinese patients with breast cancer] (PubMed id 12362311)1, 4 Ke Y....Lu D. (2002)
    595. Utilization of breast cancer screening in a clinically based sample of women after BRCA1/2 testing. (PubMed id 12376518)1, 4 Peshkin B.N....Lerman C. (2002)
    596. The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity. (PubMed id 11751867)1, 2 Sum E.Y....Visvader J.E. (2002)
    597. BRCA1 and BRCA2 mutations in a population-based study of male breast cancer. (PubMed id 11879560)1, 4 Basham V.M....Pharoah P.D. (2002)
    598. Impact of BRCA1/BRCA2 mutation testing on psychologic distress in a clinic-based sample. (PubMed id 11786581)1, 4 Schwartz M.D....Lerman C. (2002)
    599. [Frequency of the 185delAG mutation in the BRCA1 gene in Chilean healthy women with family history of breast cancer] (PubMed id 12491828)1, 4 Jara L....Ojeda J.M. (2002)
    600. Effect of BRCA mutations on the length of survival in epithelial ovarian tumors. (PubMed id 11786575)1, 4 Ben David Y....Modan B. (2002)
    601. Genetic counseling in hereditary breast/ovarian cancer in Israel: psychosocial impact and retention of genetic information. (PubMed id 12210341)1, 4 DiCastro M....Friedman E. (2002)
    602. BRCA1 and BRCA2 mutation analysis of early-onset and familial breast cancer cases in Mexico. (PubMed id 12442275)1, 2 Ruiz-Flores P....Barrera-Saldana H.A. (2002)
    603. Effect of germ-line genetic variation on breast cancer survival in a population-based study. (PubMed id 12036913)1, 4 Goode E.L....Pharoah P.P. (2002)
    604. Comprehensive analysis of 989 patients with breast or ovarian cancer provides BRCA1 and BRCA2 mutation profiles and frequencies for the German population. (PubMed id 11802209)1, 4 Meindl A. (2002)
    605. [Genetic test and prophylactic treatment in breast cancer families] (PubMed id 11977534)1, 4 Miyoshi Y. and Noguchi S. (2002)
    606. [Investigation of mutations of BRCA1 and BRCA2 genes in 52 breast cancer patients] (PubMed id 12101561)1, 4 Tereshchenko I.V....Shagiakhmetova R.A. (2002)
    607. Characterization of common BRCA1 and BRCA2 variants. (PubMed id 12215251)1, 2 Deffenbaugh A.M....Neuhausen S.L. (2002)
    608. Variation in BRCA1 cancer risks by mutation position. (PubMed id 11927492)1, 4 Thompson D. and Easton D. (2002)
    609. All in the family: evaluation of the process and content of sisters' communication about BRCA1 and BRCA2 genetic test results. (PubMed id 11807889)1, 4 Hughes C....Main D. (2002)
    610. Phosphorylation of serine 1387 in BRCA1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation. (PubMed id 12183412)1, 2 Xu B.... Kastan M.B. (2002)
    611. Diagnostic criteria for testing for BRCA1 and BRCA2: the experience of the Department of Defense Familial Breast/Ovarian Cancer Research Project. (PubMed id 11873550)1, 4 Fries M.H....Nunes M.E. (2002)
    612. Outcome of preventive surgery and screening for breast and ovarian cancer in BRCA mutation carriers. (PubMed id 11870168)1, 4 Scheuer L....Offit K. (2002)
    613. Utilization of BRCA1/2 genetic testing in the clinical setting: report from a single institution. (PubMed id 11920551)1, 4 Lee S.C....Helzlsouer K.J. (2002)
    614. SMC1 is a downstream effector in the ATM/NBS1 branch of the human S- phase checkpoint. (PubMed id 11877377)1, 2 Yazdi P.T.... Qin J. (2002)
    615. Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation. (PubMed id 12023992)1, 4 Kauff N.D....Offit K. (2002)
    616. Oral contraceptives and risk of familial breast cancer. (PubMed id 12088199)1, 4 Heimdal K....Moller P. (2002)
    617. Predictive testing for BRCA1/2: attributes, risk perception and management in a multi-centre clinical cohort. (PubMed id 11953874)1, 4 Foster C....Watson M. (2002)
    618. Psychological impact of genetic testing in women from high-risk breast cancer families. (PubMed id 12376208)1, 4 Meiser B....Tucker K. (2002)
    619. Analysis of 5382insC (BRCA1) and 6174delT (BRCA2) mutations in 382 healthy Chilean women with a family history of breast cancer. (PubMed id 12125210)1, 4 Jara L....Ojeda J.M. (2002)
    620. One year follow-up of women opting for presymptomatic testing for BRCA1 and BRCA2: emotional impact of the test outcome and decisions on risk management (surveillance or prophylactic surgery). (PubMed id 12088120)1, 4 Lodder L.N....Niermeijer M.F. (2002)
    621. BRCA1/2 genetic testing in the community setting. (PubMed id 12431973)1, 4 Chen W.Y....Li F.P. (2002)
    622. BRCAPRO validation, sensitivity of genetic testing of BRCA1/BRCA2, and prevalence of other breast cancer susceptibility genes. (PubMed id 12039933)1, 4 Berry D.A....Parmigiani G. (2002)
    623. Breast cancer risk in Ashkenazi BRCA1/2 mutation carriers: effects of reproductive history. (PubMed id 11964925)1, 4 Hartge P....Struewing J.P. (2002)
    624. BRCA1 and BRCA2 mutations in Turkish familial and non-familial ovarian cancer patients: a high incidence of mutations in non-familial cases. (PubMed id 12112655)1, 4 Yazici H....Ozcelik H. (2002)
    625. Insulin-like growth factor I polymorphism and breast cancer risk in Jewish women. (PubMed id 12389335)1, 4 Figer A....Riezel S. (2002)
    626. Clinical characteristics of individuals with germline mutations in BRCA1 and BRCA2: analysis of 10,000 individuals. (PubMed id 11896095)1, 4 Frank T.S....Critchfield G.C. (2002)
    627. Progress of a Comprehensive Familial Cancer Genetic Counseling Program in the Era of BRCA1 and BRCA2. (PubMed id 12229876)1, 4 Hartenbach E.M....Schink J.C. (2002)
    628. A brief assessment of concerns associated with genetic testing for cancer: the Multidimensional Impact of Cancer Risk Assessment (MICRA) questionnaire. (PubMed id 12433008)1, 4 Cella D....Lerman C. (2002)
    629. Novel mutations in the BRCA1 and BRCA2 genes in Iranian women with early-onset breast cancer. (PubMed id 12100744)1, 4 Yassaee V.R.... Dalton A. (2002)
    630. Psychosocial predictors of BRCA counseling and testing decisions among urban African-American women. (PubMed id 12496047)1, 4 Thompson H.S....Offit K. (2002)
    631. A European case-only study on familial breast cancer. (PubMed id 12484126)1, 4 Berrino F....Bellati C. (2002)
    632. BRCA1 mutation screening using restriction endonuclease fingerprinting-single-strand conformation polymorphism in an automated capillary electrophoresis system. (PubMed id 12481264)1, 4 Kringen P....Andersen T.I. (2002)
    633. NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain. (PubMed id 12419185)1, 2 Kobayashi J.... Komatsu K. (2002)
    634. Genetic counseling impacts decision for prophylactic surgery for patients perceived to be at high risk for breast cancer. (PubMed id 11448436)1, 4 Morris K.T....Dorsey P. (2001)
    635. CAG and GGC repeat polymorphisms in the androgen receptor gene and breast cancer susceptibility in BRCA1/2 carriers and non-carriers. (PubMed id 11437399)1, 4 Kadouri L....Eeles R.A. (2001)
    636. Measuring women's preferences for breast cancer treatments and BRCA1/BRCA2 testing. (PubMed id 11822793)1, 4 Cappelli M....Allanson J. (2001)
    637. The frequency of founder mutations in the BRCA1, BRCA2, and APC genes in Australian Ashkenazi Jews: implications for the generality of U.S. population data. (PubMed id 11466700)1, 4 Bahar A.Y....Buckley M.F. (2001)
    638. Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1. (PubMed id 11573086)1, 2 Williams R.S....Glover J.N. (2001)
    639. Psychological impact of receiving a BRCA1/BRCA2 test result. (PubMed id 11426450)1, 4 Lodder L....Niermeijer M.F. (2001)
    640. The androgen receptor and genetic susceptibility to ovarian cancer: results from a case series. (PubMed id 11221880)1, 4 Levine D.A. and Boyd J. (2001)
    641. [Information to families with hereditary breast and ovarian cancer] (PubMed id 11826460)1, 4 Levin T....Moller P. (2001)
    642. Effectiveness of breast cancer surveillance in BRCA1/2 gene mutation carriers and women with high familial risk. (PubMed id 11181654)1, 4 Brekelmans C.T....Klijn J.G. (2001)
    643. Survival of breast cancer patients in BRCA1, BRCA2, and non-BRCA1/2 breast cancer families: a relative survival analysis from Finland. (PubMed id 11433401)1, 4 Eerola H....Sankila R. (2001)
    644. [Bilateral breast carcinoma and local recurrence: prevalence of BRCA-1 and BRCA-2 gene mutations in an unselected patient sample] (PubMed id 11505617)1, 4 Bremer M....Karstens J.H. (2001)
    645. An interactive computer program can effectively educate patients about genetic testing for breast cancer susceptibility. (PubMed id 11562929)1, 4 Green M.J....Fost N. (2001)
    646. BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations. (PubMed id 11739404)1, 2 Ye Q.... Li R. (2001)
    647. Ovarian cancer BRCA1 mutation detection: Protein truncation test (PTT) outperforms single strand conformation polymorphism analysis (SSCP). (PubMed id 11668617)1, 4 Geisler J.P....Buller R.E. (2001)
    648. Psychological impact of genetic counselling and testing in women previously diagnosed with breast cancer. (PubMed id 11584901)1, 4 Randall J....Tucker K. (2001)
    649. Impact of educational print materials on knowledge, attitudes, and interest in BRCA1/BRCA2: testing among Ashkenazi Jewish women. (PubMed id 11550168)1, 4 Schwartz M.D....Johnson L. (2001)
    650. Risk of endometrial carcinoma associated with BRCA mutation. (PubMed id 11263938)1, 4 Levine D.A....Boyd J. (2001)
    651. Uptake of hereditary breast/ovarian cancer genetic testing in a French national sample of BRCA1 families. The French Cancer Genetic Network. (PubMed id 11180585)1, 4 Julian-Reynier C....Bourret P. (2000)
    652. hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. (PubMed id 10724175)1, 2 Lee J.S....Chung J.H. (2000)
    653. Low prevalence of germline BRCA1 mutations in early onset breast cancer without a family history. (PubMed id 11183185)1, 4 Ellis D....Mathew C.G. (2000)
    654. Factors associated with decisions about clinical BRCA1/2 testing. (PubMed id 11097234)1, 4 Armstrong K....Weber B. (2000)
    655. An evaluation of needs of female BRCA1 and BRCA2 carriers undergoing genetic counselling. (PubMed id 11073541)1, 4 Metcalfe K.A....Narod S.A. (2000)
    656. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. (PubMed id 10783165)1, 2 Wang Y.... Qin J. (2000)
    657. Evaluation of the needs of male carriers of mutations in BRCA1 or BRCA2 who have undergone genetic counseling. (PubMed id 11063672)1, 4 Liede A....Narod S.A. (2000)
    658. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. (PubMed id 10500182)1, 2 Lorick K.L....Weissman A.M. (1999)
    659. Molecular characterization of germline mutations in the BRCA1 and BRCA2 genes from breast cancer families in Taiwan. (PubMed id 10323242)1, 2 Li S.S.-L.... Tsai J.-H. (1999)
    660. The contribution of germline BRCA1 and BRCA2 mutations to familial ovarian cancer: no evidence for other ovarian cancer-susceptibility genes. (PubMed id 10486320)1, 2 Gayther S.A....Ponder B.A.J. (1999)
    661. Germline BRCA1 alterations in a population-based series of ovarian cancer cases. (PubMed id 10196379)1, 2 Janezic S.A.... Anton-Culver H. (1999)
    662. BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression. (PubMed id 9528852)1, 2 Jensen D.E.... Rauscher F.J. III (1998)
    663. Characterization of a carboxy-terminal BRCA1 interacting protein. (PubMed id 9811458)1, 2 Wong A.K....Bartel P.L. (1998)
    664. Constant denaturant gel electrophoresis (CDGE) in BRCA1 mutation screening. (PubMed id 9482581)1, 2 Andersen T.I.... Boerresen-Dale A.-L. (1998)
    665. Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-delta11b. (PubMed id 9010228)1, 2 Wilson C.A.... Calzone F.J. (1997)
    666. Mutations and polymorphisms in the familial early-onset breast cancer (BRCA1) gene. (PubMed id 8807330)1, 2 Couch F.J. and Weber B.L. (1996)
    667. BRCA1 mutations in primary breast and ovarian carcinomas. (PubMed id 7939630)1, 2 Futreal P.A.... Wiseman R. (1994)
    668. Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families. (PubMed id 7894493)1, 2 Friedman L.S.... King M.-C. (1994)
    669. Familial breast-ovarian cancer locus on chromosome 17q12-q23. (PubMed id 1676470)1, 3 Narod S.A....Lenoir G.M. (1991)
    670. Extracellular matrix enhances heregulin-dependent BRCA1 phosphorylation and suppresses BRCA1 expression through its C terminus. (PubMed id 12509456)1, 9 Miralem T. and Avraham H.K. (2003)
    671. BRCA1 and implications for response to chemotherapy in ovarian cancer. (PubMed id 19168207)1, 9 Quinn J.E....Harkin D.P. (2009)
    672. Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities. (PubMed id 18208621)1, 9 Press J.Z....Huntsman D.G. (2008)
    673. Inactivation of BRCA1 and BRCA2 in ovarian cancer. (PubMed id 12237285)1, 9 Hilton J.L....Buller R.E. (2002)
    674. Transcriptional autoregulation by BRCA1. (PubMed id 20068145)1, 9 De Siervi A....Gardner K. (2010)
    675. Allelic imbalance in BRCA1 and BRCA2 gene expression is associated with an increased breast cancer risk. (PubMed id 18204050)1, 9 Chen X....Godwin A.K. (2008)
    676. Phosphatidylinositol 3-kinase/Akt signaling enhances nuclear localization and transcriptional activity of BRCA1. (PubMed id 17428466)1, 9 Hinton C.V....Thompson M.E. (2007)
    677. Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha. (PubMed id 12438214)1, 9 Liu Y....Hsu L.C. (2002)
    678. BRCA1 localization to the telomere and its loss from the telomere in response to DNA damage. (PubMed id 19797051)1, 9 Ballal R.D....Rosen E.M. (2009)
    679. Tumor suppressor BRCA1 is expressed in prostate cancer and controls insulin-like growth factor I receptor (IGF-IR) gene transcription in an androgen receptor-dependent manner. (PubMed id 19223505)1, 9 Schayek H....Werner H. (2009)
    680. Loss of heterozygosity at the BRCA2 locus detected by multiplex ligation-dependent probe amplification is common in prostate cancers from men with a germline BRCA2 mutation. (PubMed id 18445692)1, 9 Willems A.J....Thorne H.J. (2008)
    681. Involvement of a specificity proteins-binding element in regulation of basal and estrogen-induced transcription activity of the BRCA1 gene. (PubMed id 18377656)1, 9 Hockings J.K....Romagnolo D.F. (2008)
    682. Ubiquitination and proteasomal degradation of the BRCA1 tumor suppressor is regulated during cell cycle progression. (PubMed id 15166217)1, 9 Choudhury A.D....Baer R. (2004)
    683. Large BRCA1 and BRCA2 genomic rearrangements in Danish high risk breast-ovarian cancer families. (PubMed id 18546071)1, 9 Hansen T.O....Nielsen F.C. (2009)
    684. Yeast screens identify the RNA polymerase II CTD and SPT5 as relevant targets of BRCA1 interaction. (PubMed id 18197258)1, 9 Bennett C.B....Marks J.R. (2008)
    685. The interaction of PP1 with BRCA1 and analysis of their expression in breast tumors. (PubMed id 17511879)1, 9 Winter S.L....Andrulis I.L. (2007)
    686. Novel consensus DNA-binding sequence for BRCA1 protein complexes. (PubMed id 14502648)1, 9 Cable P.L....Afshari C.A. (2003)
    687. Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies. (PubMed id 11278964)1, 9 Gatei M....Khanna K.K. (2001)
    688. Customized treatment in non-small-cell lung cancer based on EGFR mutations and BRCA1 mRNA expression. (PubMed id 19415121)1, 9 Rosell R....Taron M. (2009)
    689. BRCA1 is regulated by Chk2 in response to spindle damage. (PubMed id 18804494)1, 9 Chabalier-Taste C....Larminat F. (2008)
    690. BRCA1 promoter methylation in peripheral blood DNA of mutation negative familial breast cancer patients with a BRCA1 tumour phenotype. (PubMed id 18269736)1, 9 Snell C....Dobrovic A. (2008)
    691. NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway. (PubMed id 19001859)1, 9 Wilson K.A. and Stern D.F. (2008)
    692. Growth factor signaling pathways modulate BRCA1 repression of estrogen receptor-alpha activity. (PubMed id 17505062)1, 9 Ma Y....Rosen E.M. (2007)
    693. BRCA1 DNA-binding activity is stimulated by BARD1. (PubMed id 16489000)1, 9 Simons A.M....Parvin J.D. (2006)
    694. Intronic alterations in BRCA1 and BRCA2: effect on mRNA splicing fidelity and expression. (PubMed id 16619214)1, 9 Chen X....Godwin A.K. (2006)
    695. BRCA1 interaction with human papillomavirus oncoproteins. (PubMed id 15983032)1, 9 Zhang Y....Rosen E.M. (2005)
    696. Germline BRCA1 promoter deletions in UK and Australian familial breast cancer patients: Identification of a novel deletion consistent with BRCA1:psiBRCA1 recombination. (PubMed id 11933198)1, 9 Brown M.A....Solomon E. (2002)
    697. Direct interaction between BRCA1 and the estrogen receptor regulates vascular endothelial growth factor (VEGF) transcription and secretion in breast cancer cells. (PubMed id 12400015)1, 9 Kawai H....Avraham H.K. (2002)
    698. Expression of BRCA1 and BRCA2 in different tumor cell lines with various growth status. (PubMed id 11983207)1, 9 Vissac C....Bernard-Gallon D.J. (2002)
    699. Role of direct interaction in BRCA1 inhibition of estrogen receptor activity. (PubMed id 11244506)1, 9 Fan S....Rosen E.M. (2001)
    700. Altered expression of BRCA1, BRCA2, and a newly identified BRCA2 exon 12 deletion variant in malignant human ovarian, prostate, and breast cancer cell lines. (PubMed id 10972993)1, 9 Rauh-Adelmann C....Ho S.M. (2000)
    701. Mutations and alternative splicing of the BRCA1 gene in UK breast/ovarian cancer families. (PubMed id 9115959)1, 9 Xu C.F....Solomon E. (1997)
    702. BRCA1 protein and nucleolin colocalize in breast carc inoma tissue and cancer cell lines. (PubMed id 20075200)1, 9 Tulchin N....Monteiro A.N. (2010)
    703. The central region of BRCA1 binds preferentially to s upercoiled DNA. (PubMed id 19492866)1, 9 BrA!zda V....Arrowsmith C.H. (2009)
    704. PALB2 functionally connects the breast cancer suscept ibility proteins BRCA1 and BRCA2. (PubMed id 19584259)1, 9 Zhang F....Andreassen P.R. (2009)
    705. Immunolocalization of BRCA1 protein in tumor breast tissue: prescreening of BRCA1 mutation in Tunisian patients with hereditary breast cancer? (PubMed id 17921118)1, 9 Troudi W....Ben Ammar Elgaaied A. (2007)
    706. Association of BRCA1 with the inactive X chromosome and XIST RNA. (PubMed id 15065664)1, 9 Ganesan S....Livingston D.M. (2004)
    707. Role of BRCA1 in heat shock response. (PubMed id 12527903)1, 9 Xian Ma Y....Rosen E.M. (2003)
    708. Bovine BRCA1 shows classic responses to genotoxic stress but low in vitro transcriptional activation activity. (PubMed id 12955082)1, 9 Krum S.A....Lane T.F. (2003)
    709. BRCA1 regulates GADD45 through its interactions with the OCT-1 and CAAT motifs. (PubMed id 11777930)1, 9 Fan W....Zhan Q. (2002)
    710. BRCA1-induced apoptosis involves inactivation of ERK1/2 activities. (PubMed id 12082091)1, 9 Yan Y....Cowan K.H. (2002)
    711. BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases. (PubMed id 9244350)1, 9 Wang H....Rao V.N. (1997)
    712. Methylation not a frequent 'second hit' in tumors with germline BRCA mutations. (PubMed id 19340607)1, 9 Dworkin A.M....Toland A.E. (2009)
    713. Cisplatin-damaged BRCA1 exhibits altered thermostabil ity and transcriptional transactivation. (PubMed id 19270496)1, 9 Ratanaphan A....Prasertsan P. (2009)
    714. Molecular and in silico analysis of BRCA1 and BRCA2 variants. (PubMed id 18694767)1, 9 Tommasi S....Paradiso A. (2008)
    715. Twenty-three novel BRCA1 and BRCA2 sequence alterations in breast and/or ovarian cancer families of Eastern Spain. (PubMed id 18060494)1, 9 Esteban Cardenosa E....Martinez de Duenas E. (2008)
    716. Incidence of BRCA1 and BRCA2 mutations in 54 Chilean families with breast/ovarian cancer, genotype-phenotype correlations. (PubMed id 16261400)1, 9 Gallardo M....Carvallo P. (2006)
    717. BRCA1 and BRCA2 germline mutational spectrum and evidence for genetic anticipation in Portuguese breast/ovarian cancer families. (PubMed id 16826315)1, 9 Peixoto A....Teixeira M.R. (2006)
    718. Functional and physical interactions between BRCA1 and p53 in transcriptional regulation of the IGF-IR gene. (PubMed id 14710355)1, 9 Abramovitch S. and Werner H. (2003)
    719. siRNA depletion of BRCA1, but not BRCA2, causes increased genome instability in Fanconi anemia cells. (PubMed id 12967657)1, 9 Bruun D....Moses R. (2003)
    720. BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis. (PubMed id 14559807)1, 9 Quinn J.E....Harkin D.P. (2003)
    721. Correlation between BRCA1 expression and apoptosis-related biological parameters in sporadic breast carcinomas. (PubMed id 12552965)1, 9 Yang Q....Kakudo K. (2002)
    722. The p53 mutational spectrum associated with BRCA1 mutant ovarian cancer. (PubMed id 11309330)4, 9 Buller R.E....Kirby P.A. (2001)
    723. Cell cycle-dependent colocalization of BARD1 and BRCA1 proteins in discrete nuclear domains. (PubMed id 9342365)1, 9 Jin Y....Baer R. (1997)
    724. Targeting the FANCJ-BRCA1 interaction promotes a swit ch from recombination to poleta-dependent bypass. (PubMed id 20173781)1, 9 Xie J....Cantor S.B. (2010)
    725. BRCA1 promoter methylation associated with poor survi val in Chinese patients with sporadic breast cancer. (PubMed id 19522853)1, 9 Chen Y....Deng D. (2009)
    726. A novel mechanism whereby BRCA1/1a/1b fine tunes the dynamic complex interplay between SUMO-dependent/independent activities of Ubc9 on E2-induced ERalpha activation/repression and degradation in breast cancer cells. (PubMed id 19287951)1, 9 Xu J....Rao V.N. (2009)
    727. Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair. (PubMed id 18171670)1, 9 Chen L....Wu X. (2008)
    728. Nuclear export of BRCA1 occurs during early S phase and is calcium-dependent. (PubMed id 18296025)1, 9 Glover-Collins K. and Thompson M.E. (2008)
    729. Skewed X chromosome inactivation and breast and ovarian cancer status: evidence for X-linked modifiers of BRCA1. (PubMed id 18957670)1, 9 Lose F.... . (2008)
    730. The CHEK2 1100delC mutation is not present in Korean patients with breast cancer cases tested for BRCA1 and BRCA2 mutation. (PubMed id 18175216)1, 9 Choi D.H....Haffty B.G. (2008)
    731. Concerted transcriptional regulation by BRCA1 and COBRA1 in breast cancer cells. (PubMed id 18071589)1, 9 Aiyar S.E....Li R. (2007)
    732. Brca1 heterozygous mice have shortened life span and are prone to ovarian tumorigenesis with haploinsufficiency upon ionizing irradiation. (PubMed id 17420720)1, 9 Jeng Y.M....Lee W.H. (2007)
    733. Prognostic value of BRCA1 mutations in familial breast cancer patients affected by a second primary cancer. (PubMed id 17520345)1, 9 Elsakov P....Ostapenko V. (2007)
    734. BRCA1 gene expression in breast cancer: a correlative study between real-time RT-PCR and immunohistochemistry. (PubMed id 15872055)1, 9 Al-Mulla F....Anim J.T. (2005)
    735. Truncating BRCA1 mutations are uncommon in a cohort of hereditary prostate cancer families with evidence of linkage to 17q markers. (PubMed id 15447980)1, 9 Zuhlke K.A....Cooney K.A. (2004)
    736. Nuclear-cytoplasmic shuttling of BARD1 contributes to its proapoptotic activity and is regulated by dimerization with BRCA1. (PubMed id 14647430)1, 9 Rodriguez J.A....Henderson B.R. (2004)
    737. Novel germline BRCA1 and BRCA2 mutations in breast and breast/ovarian cancer families from the Czech Republic. (PubMed id 11748848)1, 9 Machackova E....Foretova L. (2001)
    738. Mapping the functional domains of BRCA1. Interaction of the ring finger domains of BRCA1 and BARD1. (PubMed id 10026184)1, 9 Meza J.E.... Klevit R.E. (1999)
    739. The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter. (PubMed id 9926942)1, 9 Chai Y.L....Rao V.N. (1999)
    740. Distinct somatic genetic changes associated with tumor progression in carriers of BRCA1 and BRCA2 germ-line mutations. (PubMed id 9102202)4, 9 Tirkkonen M....Kallioniemi O.P. (1997)
    741. Immunohistochemical expression of BRCA1 and lethal pr ostate cancer. (PubMed id 20388772)1, 9 Fiorentino M....Mucci L. (2010)
    742. Selenium supplementation reduced oxidative DNA damage in adnexectomized BRCA1 mutations carriers. (PubMed id 19843683)1, 9 Dziaman T....Olinski R. (2009)
    743. [The prevalence of BRCA1 mutations among families at high-risk of breast and ovarian cancer in province of Malopolska between 2004-2 009] (PubMed id 20514903)1, 9 Blecharz P....UrbaA8ski K. (2009)
    744. The contribution of BRCA1 and BRCA2 to ovarian cancer. (PubMed id 19383375)1, 9 Ramus S.J. and Gayther S.A. (2009)
    745. Analysis of large deletions in BRCA1, BRCA2 and PALB2 genes in Finnish breast and ovarian cancer families. (PubMed id 18501021)1, 9 PylkAos K....Winqvist R. (2008)
    746. AKT1 inhibits homologous recombination by inducing cytoplasmic retention of BRCA1 and RAD51. (PubMed id 19010915)1, 9 Plo I....Lopez B.S. (2008)
    747. Promotion of BRCA1-associated triple-negative breast cancer by ovarian hormones. (PubMed id 18197009)1, 9 Lee E.Y. (2008)
    748. The spectrum and incidence of BRCA1 pathogenic mutations in Slovak breast/ovarian cancer families. (PubMed id 17319787)1, 9 Konecny M....Kausitz J. (2007)
    749. Germline BRCA1 mutation and survival analysis in familial breast cancer patients in Kerala; South India. (PubMed id 17987791)1, 9 Vinodkumar B....Ankathil R. (2007)
    750. A review of histopathological subtypes of ovarian cancer in BRCA-related French Canadian cancer families. (PubMed id 17636423)1, 9 Tonin P.N....Provencher D.M. (2007)
    751. BRCA1 mutation and young age predict fast breast cancer growth in the Dutch, United Kingdom, and Canadian magnetic resonance imaging screening trials. (PubMed id 18094417)1, 9 Tilanus-Linthorst M.M....Gilbert F.J. (2007)
    752. The breast cancer susceptibility gene BRCA1 regulates progesterone receptor signaling in mammary epithelial cells. (PubMed id 16109739)1, 9 Ma Y....Rosen E.M. (2006)
    753. An estrogen receptor-alpha/p300 complex activates the BRCA-1 promoter at an AP-1 site that binds Jun/Fos transcription factors: repressive effects of p53 on BRCA-1 transcription. (PubMed id 16229810)1, 9 Jeffy B.D....Romagnolo D.F. (2005)
    754. 53BP1 is a positive regulator of the BRCA1 promoter. (PubMed id 15970701)1, 9 Rauch T....Xu X. (2005)
    755. In vitro platination of human breast cancer suppressor gene1 (BRCA1) by the anticancer drug carboplatin. (PubMed id 16099593)1, 9 Ratanaphan A....Mahasawat P. (2005)
    756. Cyclin D1 antagonizes BRCA1 repression of estrogen receptor alpha activity. (PubMed id 16061635)1, 9 Wang C....Pestell R.G. (2005)
    757. BARD1 regulates BRCA1 apoptotic function by a mechanism involving nuclear retention. (PubMed id 15265711)1, 9 Fabbro M....Henderson B.R. (2004)
    758. Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpoint. (PubMed id 12810625)1, 9 Yamane K....Kinsella T.J. (2003)
    759. BRCA1 augments transcription by the NF-kappaB transcription factor by binding to the Rel domain of the p65/RelA subunit. (PubMed id 12700228)1, 9 Benezra M....Licht J.D. (2003)
    760. Cancer risk estimates for BRCA1 mutation carriers identified in a risk evaluation program. (PubMed id 12237282)1, 9 Brose M.S....Weber B.L. (2002)
    761. CGH-targeted linkage analysis reveals a possible BRCA1 modifier locus on chromosome 5q. (PubMed id 12019214)1, 9 Nathanson K.L....Weber B.L. (2002)
    762. Conservation of function and primary structure in the BRCA1-associated RING domain (BARD1) protein. (PubMed id 9798686)1, 9 Ayi T.C....Baer R. (1998)
    763. Somatic mutations in the BRCA1 gene in sporadic ovarian tumours. (PubMed id 7795652)1, 9 Merajver S.D....Frank T.S. (1995)
    764. Negative feedback loop of BRCA1-BARD1 ubiquitin ligas e on estrogen receptor alpha stability and activity antagonized by cancer-assoc iated isoform of BARD1. (PubMed id 20060929)1, 9 Dizin E. and Irminger-Finger I. (2010)
    765. Use of DNA-damaging agents and RNA pooling to assess expression profiles associated with BRCA1 and BRCA2 mutation status in familial breast cancer patients. (PubMed id 20174566)1, 9 Walker L.C....Spurdle A.B. (2010)
    766. Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. (PubMed id 19648928)1, 9 Lim E....Lindeman G.J. (2009)
    767. Association of loss of BRCA1 expression with centrosome aberration in human breast cancer. (PubMed id 18813953)1, 9 Shimomura A....Noguchi S. (2009)
    768. Age at onset of bilateral breast cancer, the presence of hereditary BRCA1, BRCA2, CHEK2 gene mutations and positive family history of cancer. (PubMed id 19372713)1, 9 Skasko E....PieA8kowski T. (2009)
    769. Aneuploidy is associated with TP53 expression but not with BRCA1 or TERT expression in sporadic colorectal cancer. (PubMed id 20032382)1, 9 SchjA...De Angelis P.M. (2009)
    770. Tamoxifen and the risk of ovarian cancer in BRCA1 mut ation carriers. (PubMed id 19577280)4, 9 Vicus D....Narod S.A. (2009)
    771. Clinical characteristics of laryngeal cancer in BRCA- 1 mutation carriers. (PubMed id 19596949)1, 9 Jaworowska E....LubiA8ski J. (2009)
    772. Deletions of BRCA1/2 and p53 R248W gain-of-function mutation suggest impaired homologous recombination repair in fragile histidine triad-negative sebaceous gland carcinomas. (PubMed id 18717684)1, 9 Becker K....Ballhausen W.G. (2008)
    773. BRCA1/BRCA2 rearrangements and CHEK2 common mutations are infrequent in Italian male breast cancer cases. (PubMed id 17661168)1, 9 Falchetti M....Ottini L. (2008)
    774. Tumor BRCA1, RRM1 and RRM2 mRNA expression levels and clinical response to first-line gemcitabine plus docetaxel in non-small-cell lung cancer patients. (PubMed id 19002265)1, 9 Boukovinas I....Souglakos J. (2008)
    775. BRCA1 overexpression sensitizes cancer cells to lovastatin via regulation of cyclin D1-CDK4-p21WAF1/CIP1 pathway: analyses using a breast cancer cell line and tumoral xenograft model. (PubMed id 18695886)1, 9 Yu X....Tang Y. (2008)
    776. Risks of cancer due to a single BRCA1 mutation in an extended Utah kindred. (PubMed id 17051349)1, 9 Vogl F.D....Goldgar D.E. (2007)
    777. Promoter hypermethylation of TMS1, BRCA1, ERalpha and PRB in serum and tumor DNA of invasive ductal breast carcinoma patients. (PubMed id 17599361)1, 9 Mirza S....Ralhan R. (2007)
    778. A role of estrogen/ERalpha signaling in BRCA1-associated tissue-specific tumor formation. (PubMed id 17496925)1, 9 Li W....Deng C.X. (2007)
    779. Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer. (PubMed id 17626182)1, 9 Liu X....Jonkers J. (2007)
    780. Compromised Fanconi anemia response due to BRCA1 deficiency in cisplatin-sensitive head and neck cancer cell lines. (PubMed id 17321670)1, 9 Burkitt K. and Ljungman M. (2007)
    781. Elevated insulin-like growth factor-I receptor (IGF-IR) levels in primary breast tumors associated with BRCA1 mutations. (PubMed id 17766039)1, 9 Maor S....Werner H. (2007)
    782. Genetic analysis of BRCA1 ubiquitin ligase activity and its relationship to breast cancer susceptibility. (PubMed id 16403807)1, 9 Morris J.R....Solomon E. (2006)
    783. Basal repression of BRCA1 by multiple E2Fs and pocket proteins at adjacent E2F sites. (PubMed id 17106239)1, 9 Bindra R.S. and Glazer P.M. (2006)
    784. Expression of DNA double-strand break repair proteins ATM and BRCA1 predicts survival in colorectal cancer. (PubMed id 16533773)1, 9 Grabsch H....Mueller W. (2006)
    785. Down-regulation of BRCA1-BARD1 ubiquitin ligase by CDK2. (PubMed id 15665273)1, 9 Hayami R....Ohta T. (2005)
    786. Novel somatic mutations in the BRCA1 gene in sporadic breast tumors. (PubMed id 15712267)1, 9 Janatova M....Pohlreich P. (2005)
    787. Down-regulation of BRCA1 in chronic pancreatitis and sporadic pancreatic adenocarcinoma. (PubMed id 15173085)1, 9 Beger C....Beger H.G. (2004)
    788. Nucleophosmin/B23 is a candidate substrate for the BRCA1-BARD1 ubiquitin ligase. (PubMed id 15184379)1, 9 Sato K....Ohta T. (2004)
    789. Functional dissection of transcription factor ZBRK1 reveals zinc fingers with dual roles in DNA-binding and BRCA1-dependent transcriptional repression. (PubMed id 14660588)1, 9 Tan W....Boyer T.G. (2004)
    790. Comparison of BRCT domains of BRCA1 and 53BP1: a biophysical analysis. (PubMed id 14978302)1, 9 Ekblad C.M....Itzhaki L.S. (2004)
    791. Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control. (PubMed id 12611903)1, 9 Lou Z.... Chen J. (2003)
    792. Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein. (PubMed id 12431996)1, 9 Xia Y....Hunter T. (2003)
    793. Mutation analysis of BrCA1, BrCA2, and p53 versus soluble HLA class I and class II in a case of familial endometriosis. (PubMed id 12568865)1, 9 Goumenou A.G....Koutsilieris M. (2003)
    794. Loss of BRCA1 expression in sporadic male breast carcinoma. (PubMed id 11859870)1, 9 Sun X....Badve S. (2002)
    795. A low frequency of non-founder BRCA1 mutations in Ashkenazi Jewish breast-ovarian cancer families. (PubMed id 12402332)1, 9 Phelan C.M....Narod S.A. (2002)
    796. Analysis of BRCA1, TP53, and TSG101 germline mutations in German breast and/or ovarian cancer families. (PubMed id 12505256)1, 9 Balz V....Bojar H. (2002)
    797. Constitutive association of BRCA1 and c-Abl and its ATM-dependent disruption after irradiation. (PubMed id 12024016)1, 9 Foray N....Jeggo P. (2002)
    798. Activation of the aromatic hydrocarbon receptor pathway is not sufficient for transcriptional repression of BRCA-1: requirements for metabolism of benzo[a]pyrene to 7r,8t-dihydroxy-9t,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene. (PubMed id 11782367)1, 9 Jeffy B.D....Romagnolo D.F. (2002)
    799. Expression profiles of BRCA1 splice variants in asynchronous and in G1/S synchronized tumor cell lines. (PubMed id 11162473)1, 9 Orban T.I. and Olah E. (2001)
    800. The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation. (PubMed id 11278247)1, 9 Hashizume R....Ohta T. (2001)
    801. BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor. (PubMed id 11493692)1, 9 Zheng L....Boyer T.G. (2001)
    802. Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1. (PubMed id 11090615)1, 9 Zheng L....Lee H.W. (2000)
    803. Increase of androgen-induced cell death and androgen receptor transactivation by BRCA1 in prostate cancer cells. (PubMed id 11016951)1, 9 Yeh S....Chang C. (2000)
    804. BRCA1 inhibition of estrogen receptor signaling in transfected cells. (PubMed id 10334989)1, 9 Fan S....Rosen E.M. (1999)
    805. Association of BRCA1 with Rad51 in mitotic and meiotic cells. (PubMed id 9008167)1, 9 Scully R....Livingston D.M. (1997)
    806. Hereditary breast and ovarian cancer due to mutations in BRCA1 and BRCA2. (PubMed id 20216074)1, 9 Petrucelli N....Feldman G.L. (2010)
    807. BRCA1 mutations in women with familial or early-onset breast cancer and BRCA2 mutations in familial cancer in Estonia. (PubMed id 20380699)1, 9 Tamboom K....Veidebaum T. (2010)
    808. Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote res ponses to DNA double-strand breaks. (PubMed id 20016603)1, 9 Galanty Y....Jackson S.P. (2009)
    809. BRCA1 expression and molecular alterations in familial breast cancer. (PubMed id 19012246)1, 9 Mangia A....Paradiso A. (2009)
    810. Promoter methylation patterns of ATM, ATR, BRCA1, BRC A2 and P53 as putative cancer risk modifiers in Jewish BRCA1/BRCA2 mutation car riers. (PubMed id 18642075)1, 9 Kontorovich T....Friedman E. (2009)
    811. A role for BRCA1 in uterine leiomyosarcoma. (PubMed id 19843854)1, 9 Xing D....Orsulic S. (2009)
    812. Expression profile of BRCA1 and BRCA2 genes in premen opausal Mexican women with breast cancer: clinical and immunohistochemical corr elates. (PubMed id 19012002)1, 9 Loredo-Pozos G....Ramos-MA!rquez M.E. (2009)
    813. Resveratrol induces senescence-like growth inhibition of U-2 OS cells associated with the instability of telomeric DNA and upregulat ion of BRCA1. (PubMed id 19559722)1, 9 Rusin M....Butkiewicz D. (2009)
    814. BRCA1 down-regulates cellular levels of reactive oxygen species. (PubMed id 19364506)1, 9 Saha T....Rosen E.M. (2009)
    815. The DNA repair proteins BRCA1 and ERCC1 as predictive markers in sporadic ovarian cancer. (PubMed id 19035454)1, 9 Weberpals J....Dimitroulakos J. (2009)
    816. Distinct roles of BARD1 isoforms in mitosis: full-length BARD1 mediates Aurora B degradation, cancer-associated BARD1beta scaffolds Aurora B and BRCA2. (PubMed id 19176389)1, 9 Ryser S....Irminger-Finger I. (2009)
    817. Decreased BRCA1 confers tamoxifen resistance in breast cancer cells by altering estrogen receptor-coregulator interactions. (PubMed id 18997820)1, 9 Wen J....Shupnik M.A. (2009)
    818. Dynamic interactions between the promoter and terminator regions of the mammalian BRCA1 gene. (PubMed id 18375767)1, 9 Tan-Wong S.M....Brown M.A. (2008)
    819. Expression of BRCA1 protein in breast cancer and its prognostic significance. (PubMed id 18400253)1, 9 Rakha E.A....Ellis I.O. (2008)
    820. [Influence of mifepristone on DNA repair genes and cisplatin sensitivity in human ovarian cancer drug-resistance cells] (PubMed id 18683754)1, 9 Liu G.Y....Qi J. (2008)
    821. [Evaluation of stomatognathic system in BRCA1 gene mutation carriers before and after prophylactic adnexectomy--part II: evaluation of stomatognathic system in BRCA1 gene mutation carriers after prophylactic adnexectomy] (PubMed id 19374245)1, 9 ChruA9ciel-Nogalska M. (2008)
    822. Re-engineering a split-GFP reassembly screen to examine RING-domain interactions between BARD1 and BRCA1 mutants observed in cancer patients. (PubMed id 18493658)1, 9 Sarkar M. and Magliery T.J. (2008)
    823. BRCA1 mRNA expression levels predict for overall survival in ovarian cancer after chemotherapy. (PubMed id 18094425)1, 9 Quinn J.E....Harkin D.P. (2007)
    824. RAD51 up-regulation bypasses BRCA1 function and is a common feature of BRCA1-deficient breast tumors. (PubMed id 17942895)1, 9 Martin R.W....Bishop D.K. (2007)
    825. X inactive-specific transcript RNA coating and genetic instability of the X chromosome in BRCA1 breast tumors. (PubMed id 17545591)1, 9 Vincent-Salomon A....Heard E. (2007)
    826. Elevated levels of somatic mutation in a manifesting BRCA1 mutation carrier. (PubMed id 18158561)1, 9 Grant S.G....Latimer J.J. (2007)
    827. The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells. (PubMed id 17581638)1, 9 Peng M....Cantor S.B. (2007)
    828. Regulation of the BRCA1 promoter in ovarian surface epithelial cells and ovarian carcinoma cells. (PubMed id 17434164)1, 9 Graves M.L....Roskelley C.D. (2007)
    829. Medullary carcinoma of breast with a novel germline mutation 1123T >G in exon 11 of BRCA1. (PubMed id 16945238)1, 9 Moattar T....Pervez S. (2006)
    830. TP53 mutations in ovarian carcinomas from sporadic ca ses and carriers of two distinct BRCA1 founder mutations; relation to age at di agnosis and survival. (PubMed id 16229746)1, 9 Kringen P....Dorum A. (2005)
    831. Phosphorylated BRCA1 is predominantly located in the nucleus and mitochondria. (PubMed id 15591126)1, 9 Coene E.D....Vaux D.J. (2005)
    832. Modulation of aromatase expression by BRCA1: a possible link to tissue-specific tumor suppression. (PubMed id 16170371)1, 9 Hu Y....Li R. (2005)
    833. BRCA1 in hormonal carcinogenesis: basic and clinical research. (PubMed id 16172191)1, 9 Rosen E.M....Isaacs C. (2005)
    834. BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly. (PubMed id 16217032)1, 9 Lin S.Y....Elledge S.J. (2005)
    835. ATR and GADD45alpha mediate HIV-1 Vpr-induced apoptosis. (PubMed id 15650754)1, 9 Andersen J.L....Planelles V. (2005)
    836. BRCA1 gene expression in breast cancer in Kuwait: correlation with prognostic parameters. (PubMed id 15785095)1, 9 Amirrad M....Anim J.T. (2005)
    837. BRCA1 and pancreatic cancer: pedigree findings and their causal relationships. (PubMed id 15796958)1, 9 Lynch H.T....Brand R.E. (2005)
    838. RNA analysis reveals splicing mutations and loss of expression defects in MLH1 and BRCA1. (PubMed id 15300854)1, 9 Sharp A.... Eccles D. (2004)
    839. BRCA1 induces antioxidant gene expression and resistance to oxidative stress. (PubMed id 15520196)1, 9 Bae I....Rosen E.M. (2004)
    840. Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair. (PubMed id 14701743)1, 9 Zhang J....Xia F. (2004)
    841. Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling. (PubMed id 15125843)1, 9 Shiozaki E.N....Shi Y. (2004)
    842. BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage. (PubMed id 15159397)1, 9 Fabbro M....Khanna K.K. (2004)
    843. BRCA1 and p53: compensatory roles in DNA repair. (PubMed id 13679996)1, 9 Hartman A.R. and Ford J.M. (2003)
    844. A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein. (PubMed id 12773400)1, 9 Foray N....Jeggo P. (2003)
    845. BRCA1 splice variants exhibit overlapping and distinct transcriptional transactivation activities. (PubMed id 12682913)1, 9 McEachern K.A....Arrick B.A. (2003)
    846. Control of biochemical reactions through supramolecular RING domain self-assembly. (PubMed id 12438698)1, 9 Kentsis A....Borden K.L. (2002)
    847. Transactivation of repair genes by BRCA1. (PubMed id 12496474)1, 9 El-Deiry W.S. (2002)
    848. S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51. (PubMed id 12239151)1, 9 Taniguchi T.... D'Andrea A.D. (2002)
    849. Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure. (PubMed id 11877378)1, 9 Joo W.S....Pavletich N.P. (2002)
    850. The BRCA1 and BARD1 association with the RNA polymerase II holoenzyme. (PubMed id 12154023)1, 9 Chiba N. and Parvin J.D. (2002)
    851. Loss of heterozygosity of p53, BRCA1, VHL, and estrogen receptor genes in breast carcinoma: correlation with related protein products and morphologic features. (PubMed id 12490973)1, 9 Otis C.N....Merino M.J. (2002)
    852. p300 Modulates the BRCA1 inhibition of estrogen receptor activity. (PubMed id 11782371)1, 9 Fan S....Rosen E.M. (2002)
    853. Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes. (PubMed id 10868478)1, 9 Meng Q....Fan S. (2000)
    854. Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells. (PubMed id 10542266)1, 9 Altiok S....Avraham H. (1999)
    855. The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression. (PubMed id 9738006)1, 9 Yu X....Baer R. (1998)
    856. Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. (PubMed id 9267023)1, 9 Scully R....Livingston D.M. (1997)
    857. A comparison of BRCA1 nuclear localization with 14 DN A damage response proteins and domains: identification of specific differences between BRCA1 and 53BP1 at DNA damage-induced foci. (PubMed id 19766185)1, 9 Mok M.T. and Henderson B.R. (2010)
    858. Concomitant loss of heterozygosity at the BRCA1 and F HIT genes as a prognostic factor in sporadic breast cancer. (PubMed id 20417865)1, 9 Silva Soares Souza Fonseca Ribeiro E.M. (2010)
    859. 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers. (PubMed id 20453858)1, 9 Bouwman P....Jonkers J. (2010)
    860. The prognostic value of BRCA1 mRNA expression levels following neoadjuvant chemotherapy in breast cancer. (PubMed id 20209131)1, 9 Margeli M....Rosell R. (2010)
    861. BRCA1 regulates acetylation and ubiquitination of est rogen receptor-alpha. (PubMed id 19887647)1, 9 Ma Y....Rosen E.M. (2010)
    862. DNA methylation profiling in doxorubicin treated prim ary locally advanced breast tumours identifies novel genes associated with surv ival and treatment response. (PubMed id 20338046)1, 9 Dejeux E....Tost J. (2010)
    863. Characterization of BRCA1 and BRCA2 deleterious mutat ions and variants of unknown clinical significance in unilateral and bilateral breast cancer: the WECARE study. (PubMed id 20104584)1, 9 Borg A....Bernstein J.L. (2010)
    864. HOXA9 regulates BRCA1 expression to modulate human br east tumor phenotype. (PubMed id 20389018)1, 9 Gilbert P.M....Weaver V.M. (2010)
    865. BRCA1/BARD1 E3 ubiquitin ligase can modify histones H 2A and H2B in the nucleosome particle. (PubMed id 19916563)1, 9 Thakar A....Zlatanova J. (2010)
    866. Downregulation of EZH2 decreases growth of estrogen receptor-negative invasive breast carcinoma and requires BRCA1. (PubMed id 19079346)1, 9 Gonzalez M.E....Kleer C.G. (2009)
    867. Hereditary ovarian carcinoma: heterogeneity, molecular genetics, pathology, and management. (PubMed id 19383374)1, 9 Lynch H.T....Godwin A.K. (2009)
    868. Role of BRCA1, HSD17B1 and HSD17B2 methylation in bre ast cancer tissue. (PubMed id 19729830)1, 9 Bhavani V....Hasan Q. (2009)
    869. Prognostic relevance of promoter hypermethylation of multiple genes in breast cancer patients. (PubMed id 19940364)1, 9 Sharma G....Ralhan R. (2009)
    870. A novel BRCA1 mutation in a Spanish patient with ovarian cancer. (PubMed id 18278587)1, 9 Salgado J....GarcA-a-Foncillas J. (2009)
    871. PALB2 links BRCA1 and BRCA2 in the DNA-damage response. (PubMed id 19268590)1, 9 Zhang F....Yu X. (2009)
    872. Utility of DNA repair protein foci for the detection of putative BRCA1 pathway defects in breast cancer biopsies. (PubMed id 19671671)1, 9 Willers H....Powell S.N. (2009)
    873. BRCA1 promoter methylation is associated with increas ed mortality among women with breast cancer. (PubMed id 18521744)1, 9 Xu X....Chen J. (2009)
    874. Ubiquitination and downregulation of BRCA1 by ubiquit in-conjugating enzyme E2T overexpression in human breast cancer cells. (PubMed id 19887602)1, 9 Ueki T....Katagiri T. (2009)
    875. Premature senescence is a major response to DNA cross -linking agents in BRCA1-defective cells: implication for tailored treatments o f BRCA1 mutation carriers. (PubMed id 19372557)1, 9 Santarosa M....Maestro R. (2009)
    876. Association of hormone receptor status with grading, age of onset, and tumor size in BRCA1-associated breast cancer. (PubMed id 19381686)1, 9 Graeser M....Schmutzler R.K. (2009)
    877. Prolactin blocks nuclear translocation of VDR by regulating its interaction with BRCA1 in osteosarcoma cells. (PubMed id 19074549)1, 9 Deng C....Walker A.M. (2009)
    878. A novel deletion of BRCA1 gene that eliminates the ATG initiation codon without affecting the promoter region. (PubMed id 19393826)1, 9 Marino M....Calandra S. (2009)
    879. BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activity. (PubMed id 19117993)1, 9 Nishikawa H....Ohta T. (2009)
    880. Inactivation of the Nijmegen breakage syndrome gene leads to excess centrosome duplication via the ATR/BRCA1 pathway. (PubMed id 19244116)1, 9 Shimada M....Komatsu K. (2009)
    881. XPG mRNA expression levels modulate prognosis in resected non-small-cell lung cancer in conjunction with BRCA1 and ERCC1 expression. (PubMed id 19289372)1, 9 Bartolucci R....Rosell R. (2009)
    882. Human SNF5/INI1, a component of the human SWI/SNF chr omatin remodeling complex, promotes nucleotide excision repair by influencing A TM recruitment and downstream H2AX phosphorylation. (PubMed id 19805520)1, 9 Ray A....Wani A.A. (2009)
    883. Promoter hypermethylation of BRCA1 correlates with absence of expression in hereditary breast cancer tumors. (PubMed id 18567944)1, 9 Tapia T....Carvallo P. (2008)
    884. BRCA1-mediated ubiquitination inhibits topoisomerase II alpha activity in response to oxidative stress. (PubMed id 18162055)1, 9 Shinagawa H....Yoshida K. (2008)
    885. Methylation is less abundant in BRCA1-associated compared with sporadic breast cancer. (PubMed id 18647968)1, 9 Suijkerbuijk K.P....van Diest P.J. (2008)
    886. On the dynamics of breast tumor development in women carrying germline BRCA1 and BRCA2 mutations. (PubMed id 18098285)1, 9 Simon R. and Zhang X. (2008)
    887. BRCA1 5083del19 mutant allele selectively up-regulates periostin expression in vitro and in vivo. (PubMed id 18980973)1, 9 Quaresima B....Costanzo F. (2008)
    888. Gamma-irradiation-induced DNA damage checkpoint activation involves feedback regulation between extracellular signal-regulated kinase 1/2 and BRCA1. (PubMed id 18593910)1, 9 Yan Y....Cowan K.H. (2008)
    889. Occult fallopian tube cancer in a patient with BRCA1 breast cancer. (PubMed id 18971141)1, 9 Brown J.V....Goldstein B.H. (2008)
    890. BRCA1 regulates human mammary stem/progenitor cell fate. (PubMed id 18230721)1, 9 Liu S....Wicha M.S. (2008)
    891. Estrogen receptor alpha, BRCA1, and FANCF promoter methylation occur in distinct subsets of sporadic breast cancers. (PubMed id 17932744)1, 9 Wei M....Olopade O.I. (2008)
    892. Loss of expression of FANCD2 protein in sporadic and hereditary breast cancer. (PubMed id 17333336)1, 9 van der Groep P....van Diest P.J. (2008)
    893. BRCA1 knock-down causes telomere dysfunction in mammary epithelial cells. (PubMed id 19188703)1, 9 Cabuy E....Slijepcevic P. (2008)
    894. Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance. (PubMed id 18413725)1, 9 Swisher E.M....Taniguchi T. (2008)
    895. Clinical classification of BRCA1 and BRCA2 DNA sequence variants: the value of cytokeratin profiles and evolutionary analysis--a report from the kConFab Investigators. (PubMed id 18375895)1, 9 Spurdle A.B....Goldgar D.E. (2008)
    896. Prolonged survival among women with BRCA germline mutations and advanced endometrial cancer: a case series. (PubMed id 17645508)1, 9 Kwon J.S....Ainsworth P. (2008)
    897. Does the nonsense-mediated mRNA decay mechanism prevent the synthesis of truncated BRCA1, CHK2, and p53 proteins? (PubMed id 17694537)1, 9 Anczukow O....Mazoyer S. (2008)
    898. Occurrence of both breast and ovarian cancer in a woman is a marker for the BRCA gene mutations: a population-based study from western Sweden. (PubMed id 16944270)1, 9 Einbeigi Z....Karlsson P. (2007)
    899. Estrogen receptor alpha is a putative substrate for the BRCA1 ubiquitin ligase. (PubMed id 17392432)1, 9 Eakin C.M....Klevit R.E. (2007)
    900. Identification and in silico analysis of functional SNPs of the BRCA1 gene. (PubMed id 17719744)1, 9 Rajasekaran R....Sethumadhavan R. (2007)
    901. Effects of BRCA1 transgene expression on murine mammary gland development and mutagen-induced mammary neoplasia. (PubMed id 17505536)1, 9 Hoshino A....Jensen R.A. (2007)
    902. BRCA1a has antitumor activity in TN breast, ovarian and prostate cancers. (PubMed id 17384678)1, 9 Yuli C....Rao V.N. (2007)
    903. FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein. (PubMed id 17596542)1, 9 Gupta R....Brosh R.M. (2007)
    904. Ubiquitination and proteasome-mediated degradation of BRCA1 and BARD1 during steroidogenesis in human ovarian granulosa cells. (PubMed id 17185394)1, 9 Lu Y....Hu Y. (2007)
    905. The BRCA1/2 pathway prevents hematologic cancers in addition to breast and ovarian cancers. (PubMed id 17683622)1, 9 Friedenson B. (2007)
    906. Tumor suppressor BRCA1 inhibits a breast cancer-associated promoter of the aromatase gene (CYP19) in human adipose stromal cells. (PubMed id 16940470)1, 9 Ghosh S....Li R. (2007)
    907. Identification of sequences that target BRCA1 to nuclear foci following alkylative DNA damage. (PubMed id 17531442)1, 9 Au W.W. and Henderson B.R. (2007)
    908. Heterozygote BRCA1 status and skewed chromosome X inactivation. (PubMed id 16944269)1, 9 Helbling-Leclere A....Feunteun J. (2007)
    909. BRCA1 regulates IFN-gamma signaling through a mechanism involving the type I IFNs. (PubMed id 17374731)1, 9 Buckley N.E....Mullan P.B. (2007)
    910. Epigenetic inactivation of the chromosomal stability control genes BRCA1, BRCA2, and XRCC5 in non-small cell lung cancer. (PubMed id 17289874)1, 9 Lee M.N....Wang Y.C. (2007)
    911. A mutation in the 5' untranslated region of the BRCA1 gene in sporadic breast cancer causes downregulation of translation efficiency. (PubMed id 17697535)1, 9 Wang J....Ma X. (2007)
    912. HIV-1 Vpr induces ATM-dependent cellular signal with enhanced homologous recombination. (PubMed id 16983346)1, 9 Nakai-Murakami C....Ishizaka Y. (2007)
    913. Molecular basis for estrogen receptor alpha deficiency in BRCA1-linked breast cancer. (PubMed id 18000219)1, 9 Hosey A.M....Harkin D.P. (2007)
    914. Familial breast/ovarian cancer and BRCA1/2 genetic screening: the role of immunohistochemistry as an additional method in the selection of patients. (PubMed id 17625228)1, 9 Vaz F.H....Andre S.P. (2007)
    915. Substrates of the BRCA1-dependent ubiquitin ligase. (PubMed id 16479151)1, 9 Starita L.M. and Parvin J.D. (2006)
    916. Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes. (PubMed id 16391231)1, 9 Greenberg R.A....Livingston D.M. (2006)
    917. Genetic instability of BRCA1 gene at locus D17S855 is related to clinicopathological behaviors of gastric cancer from Chinese population. (PubMed id 16830385)1, 9 Chen X.R....Wang J.W. (2006)
    918. New role for nuclear hormone receptors and coactivators in regulation of BRCA1-mediated DNA repair in breast cancer cell lines. (PubMed id 16417649)1, 9 Crowe D.L. and Lee M.K. (2006)
    919. BRCA1 suppresses osteopontin-mediated breast cancer. (PubMed id 16807234)1, 9 El-Tanani M.K....Rudland P.S. (2006)
    920. Missense mutations of BRCA1 gene affect the binding with p53 both in vitro and in vivo. (PubMed id 16969499)1, 9 Quaresima B....Venuta S. (2006)
    921. Lack of germ-line promoter methylation in BRCA1-negative families with familial breast cancer. (PubMed id 17253935)1, 9 Chen Y....Ziegler J.L. (2006)
    922. A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites. (PubMed id 16628214)1, 9 Polanowska J....Boulton S.J. (2006)
    923. BRCA1 negatively regulates the cancer-associated aromatase promoters I.3 and II in breast adipose fibroblasts and malignant epithelial cells. (PubMed id 16940443)1, 9 Lu M....Bulun S.E. (2006)
    924. An hGCN5/TRRAP histone acetyltransferase complex co-activates BRCA1 transactivation function through histone modification. (PubMed id 16260778)1, 9 Oishi H....Kato S. (2006)
    925. Pathology and gene expression of hereditary breast tumors associated with BRCA1, BRCA2 and CHEK2 gene mutations. (PubMed id 16998498)1, 9 Honrado E....Benitez J. (2006)
    926. BRCA1/BARD1 ubiquitinate phosphorylated RNA polymerase II. (PubMed id 15886201)1, 9 Starita L.M....Chiba N. (2005)
    927. Structural determinants of the BRCA1 : estrogen receptor interaction. (PubMed id 15674350)1, 9 Ma Y.X....Rosen E.M. (2005)
    928. Understanding breast cancer risk -- where do we stand in 2005? (PubMed id 15784178)1, 9 Dumitrescu R.G. and Cotarla I. (2005)
    929. BRCA1 and c-Myc associate to transcriptionally repress psoriasin, a DNA damage-inducible gene. (PubMed id 16288014)1, 9 Kennedy R.D....Harkin D.P. (2005)
    930. BRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II. (PubMed id 15905410)1, 9 Kleiman F.E....Manley J.L. (2005)
    931. Use of adenoviral E1A protein to analyze K18 promoter deregulation in colon carcinoma cells discloses a role for CtBP1 and BRCA1. (PubMed id 15831101)1, 9 Delouis C....Brison O. (2005)
    932. [Genetic instability on chromosome 17q21 in gastric cancer of Chinese patients] (PubMed id 16011248)1, 9 Lin X.Q....Li J.C. (2005)
    933. Structural basis for cell cycle checkpoint control by the BRCA1-CtIP complex. (PubMed id 16101277)2, 9 Varma A.K....Ladias J.A. (2005)
    934. High proportion of recurrent germline mutations in the BRCA1 gene in breast and ovarian cancer patients from the Prague area. (PubMed id 16168118)1, 9 Pohlreich P....Matous B. (2005)
    935. An amino-terminal motif functions as a second nuclear export sequence in BRCA1. (PubMed id 15811849)1, 9 Thompson M.E....Holt J.T. (2005)
    936. Centrosomal microtubule nucleation activity is inhibited by BRCA1-dependent ubiquitination. (PubMed id 16166645)1, 9 Sankaran S....Parvin J.D. (2005)
    937. Recent developments in critical genes in the molecular biology of breast cancer. (PubMed id 15691805)1, 9 Sunpaweravong S. and Sunpaweravong P. (2005)
    938. Hyperphosphorylation of the BARD1 tumor suppressor in mitotic cells. (PubMed id 15855157)1, 9 Choudhury A.D....Baer R. (2005)
    939. BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number. (PubMed id 15367667)1, 9 Starita L.M....Parvin J.D. (2004)
    940. MYC is amplified in BRCA1-associated breast cancers. (PubMed id 14760071)1, 9 Grushko T.A....Olopade O.I. (2004)
    941. Fidelity of DNA double-strand break repair in heterozygous cell lines harbouring BRCA1 missense mutations. (PubMed id 14647443)1, 9 Coupier I....Stoppa-Lyonnet D. (2004)
    942. Mass spectrometric and mutational analyses reveal Lys-6-linked polyubiquitin chains catalyzed by BRCA1-BARD1 ubiquitin ligase. (PubMed id 14638690)1, 9 Nishikawa H....Ohta T. (2004)
    943. Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. (PubMed id 15220350)1, 9 Xu X.... Stern D.F. (2004)
    944. BRCA1 inhibits membrane estrogen and growth factor receptor signaling to cell proliferation in breast cancer. (PubMed id 15199145)1, 9 Razandi M....Levin E.R. (2004)
    945. Is systemic disease in the coelomic epithelium associated with BRCA1 germline mutations? (PubMed id 15026477)4, 9 Pautier P....Spatz A. (2004)
    946. [A paradox and three egnimas about the role of BRCA1 in breast and ovarian cancers] (PubMed id 15368961)1, 9 Feunteun J. (2004)
    947. BRCA1 in hormone-responsive cancers. (PubMed id 14516936)1, 9 Rosen E.M....Goldberg I.D. (2003)
    948. BRCA1 gene in breast cancer. (PubMed id 12767038)1, 9 Rosen E.M....Goldberg I.D. (2003)
    949. A mutation analysis of the BRCA1 gene in 140 families from southeast France with a history of breast and/or ovarian cancer. (PubMed id 12827452)1, 9 Rostagno P....Frenay M. (2003)
    950. Negative regulation of BRCA1 gene expression by HMGA1 proteins accounts for the reduced BRCA1 protein levels in sporadic breast carcinoma. (PubMed id 12640109)1, 9 Baldassarre G....Fusco A. (2003)
    951. A specific GFP expression assay, penetrance estimate, and histological assessment for a putative splice site mutation in BRCA1. (PubMed id 12815598)1, 9 Southey M.C....Armes J.E. (2003)
    952. Enhanced sensitivity of peripheral blood lymphocytes from women carrying a BRCA1 mutation towards the mutagenic effects of various cytostatics. (PubMed id 14644329)1, 9 Trenz K....Speit G. (2003)
    953. BRCT repeats as phosphopeptide-binding modules involved in protein targeting. (PubMed id 14576432)1, 9 Manke I.A.... Yaffe M.B. (2003)
    954. Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas. (PubMed id 12925972)1, 9 Sutherland K.D....Campbell I.G. (2003)
    955. BRCA1 expression modulates chemosensitivity of BRCA1-defective HCC1937 human breast cancer cells. (PubMed id 12698198)1, 9 Tassone P....Venuta S. (2003)
    956. Down-regulation of BRCA1 in BCR-ABL-expressing hematopoietic cells. (PubMed id 12576338)1, 9 Deutsch E....Bourhis J. (2003)
    957. The role of the breast cancer susceptibility gene 1 (BRCA1) in sporadic epithelial ovarian cancer. (PubMed id 14613551)1, 9 McCoy M.L....Roskelley C.D. (2003)
    958. The BRCT domain is a phospho-protein binding domain. (PubMed id 14576433)1, 9 Yu X.... Chen J. (2003)
    959. Androgen pathway dysregulation in BRCA1-mutated breast tumors. (PubMed id 12779088)1, 9 Berns E.M....van der Kwast T.H. (2003)
    960. BRCA1 and BRCA2 mutations have no major role in predisposition to prostate cancer in Finland. (PubMed id 12920090)1, 9 Ikonen T....Schleutker J. (2003)
    961. Histopathological characteristics of BRCA1- and BRCA2-associated intraperitoneal cancer: a clinic-based study. (PubMed id 14574155)1, 9 Piek J.M....Menko F.H. (2003)
    962. Survival in prospectively ascertained familial breast cancer: analysis of a series stratified by tumour characteristics, BRCA mutations and oophorectomy. (PubMed id 12237897)1, 9 Moller P....Heimdal K. (2002)
    963. 53BP1, a mediator of the DNA damage checkpoint. (PubMed id 12364621)1, 9 Wang B....Elledge S.J. (2002)
    964. Frequent loss of BRCA1 nuclear expression in young women with breast cancer: an immunohistochemical study from an area of low incidence but early onset. (PubMed id 12607598)1, 9 Lee W.Y. (2002)
    965. BRCA1 directs a selective p53-dependent transcriptional response towards growth arrest and DNA repair targets. (PubMed id 12024039)1, 9 MacLachlan T.K....El-Deiry W.S. (2002)
    966. BRCA1 and BRCA2 mutations in Russian familial breast cancer. (PubMed id 11793480)1, 9 Tereschenko I.V....Pharoah P.D. (2002)
    967. Mutations in the BRCT domain confer temperature sensitivity to BRCA1 in transcription activation. (PubMed id 12496477)1, 9 Carvalho M.A....Monteiro A.N. (2002)
    968. Characterization of 2 novel and 2 recurring BRCA1 germline mutations in breast and/or ovarian carcinoma patients from the area of Naples. (PubMed id 11956590)1, 9 Curci A....Viglietto G. (2002)
    969. Analysis of murine Brca2 reveals conservation of protein-protein interactions but differences in nuclear localization signals. (PubMed id 11477095)1, 9 Sarkisian C.J....Chodosh L.A. (2001)
    970. Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding. (PubMed id 11521194)1, 9 Fan S....Rosen E.M. (2001)
    971. The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression. (PubMed id 11257228)1, 9 Kleiman F.E. and Manley J.L. (2001)
    972. Redistribution of BRCA1 among four different protein complexes following replication blockage. (PubMed id 11504724)1, 9 Chiba N. and Parvin J.D. (2001)
    973. Adenosine nucleotide modulates the physical interaction between hMSH2 and BRCA1. (PubMed id 11498787)1, 9 Wang Q....Greene M.I. (2001)
    974. Constitutive activation of JAK-STAT3 signaling by BRCA1 in human prostate cancer cells. (PubMed id 11163768)1, 9 Gao B....Fan S. (2001)
    975. VCP, a weak ATPase involved in multiple cellular events, interacts physically with BRCA1 in the nucleus of living cells. (PubMed id 10855792)1, 9 Zhang H....Greene M.I. (2000)
    976. A novel human rad54 homologue, Rad54B, associates with Rad51. (PubMed id 10851248)1, 9 Tanaka K....Miyagawa K. (2000)
    977. Ataxia telangiectasia-related protein is involved in the phosphorylation of BRCA1 following deoxyribonucleic acid damage. (PubMed id 11016625)1, 9 Chen J. (2000)
    978. Roles of BRCA1 and its interacting proteins. (PubMed id 10918303)1, 9 Deng C.X. and Brodie S.G. (2000)
    979. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. (PubMed id 10959836)1, 9 Paull T.T....Bonner W.M. (2000)
    980. Identification of a functional nuclear export sequence in BRCA1. (PubMed id 10991937)1, 9 Rodriguez J.A. and Henderson B.R. (2000)
    981. Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor. (PubMed id 10764811)1, 9 Yu X. and Baer R. (2000)
    982. Screening for germ-line rearrangements and regulatory mutations in BRCA1 led to the identification of four new deletions. (PubMed id 9927062)1, 9 Puget N....Mazoyer S. (1999)
    983. Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response. (PubMed id 10426999)1, 9 Zhong Q.... Lee W.-H. (1999)
    984. Substrate specificities and identification of putative substrates of ATM kinase family members. (PubMed id 10608806)1, 9 Kim S.-T.... Kastan M.B. (1999)
    985. Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. (PubMed id 10550055)1, 9 Cortez D.... Elledge S.J. (1999)
    986. BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site. (PubMed id 10373534)1, 9 Ruffner H....Verma I.M. (1999)
    987. Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. (PubMed id 9774970)1, 9 Chen J....Scully R. (1998)
    988. A breast cancer patient of Scottish descent with germ-line mutations in BRCA1 and BRCA2. (PubMed id 9585617)1, 9 Liede A....Narod S.A. (1998)
    989. BRCA1 gene mutations in women with papillary serous carcinoma of the peritoneum. (PubMed id 9764635)1, 9 Bandera C.A....Mok S.C. (1998)
    990. Molecular evidence for multifocal papillary serous carcinoma of the peritoneum in patients with germline BRCA1 mutations. (PubMed id 9625172)1, 9 Schorge J.O....Mok S.C. (1998)
    991. Frequently occurring germ-line mutations of the BRCA1 gene in ovarian cancer families from Russia. (PubMed id 9150173)1, 9 Gayther S.A....Ponder B.A. (1997)
    992. BRCA1 and BRCA2 mRNA levels are coordinately elevated in human breast cancer cells in response to estrogen. (PubMed id 8895509)1, 9 Spillman M.A. and Bowcock A.M. (1996)
    993. Germ-line BRCA1 mutations in selected men with prostate cancer. (PubMed id 8644752)1, 9 Langston A.A....Ostrander E.A. (1996)
    994. CtBP1 is expressed in melanoma and represses the trans cription of p16INK4a and Brca1. (PubMed id 23303449)1 Deng H....Zhang Q. (2013)
    995. Prognostic significance of BRCA1 expression in gastric cancer. (PubMed id 23292835)1 Chen W....Liu P. (2013)
    996. BRCA1-Dependent Translational Regulation in Breast Can cer Cells. (PubMed id 23805307)1 Dacheux E....Venezia N.D. (2013)
    997. Outcome of metastatic breast cancer in selected women with or without deleterious BRCA mutations. (PubMed id 23370825)1 Bayraktar S....Arun B.K. (2013)
    998. X chromosome inactivation pattern in BRCA gene mutatio n carriers. (PubMed id 23146957)1 Manoukian S....Miozzo M. (2013)
    999. Methylation of BRCA1 promoter region is associated wit h unfavorable prognosis in women with early-stage breast cancer. (PubMed id 23405268)1 Hsu N.C....Hou M.F. (2013)
    1000. Characteristics of women with ovarian carcinoma who ha ve BRCA1 and BRCA2 mutations not identified by clinical testing. (PubMed id 23262210)1 Norquist B.M....Swisher E.M. (2013)
    1001. Mutation screening of the BRCA1 gene in early onset an d familial breast/ovarian cancer in Moroccan population. (PubMed id 23289006)1 Laraqui A....Bignon Y.J. (2013)
    1002. BRCA1-Ku80 protein interaction enhances end-joining fi delity of chromosomal double-strand breaks in the G1 phase of the cell cycle. (PubMed id 23344954)1 Jiang G....Xia F. (2013)
    1003. Genome-wide association study in BRCA1 mutation carrie rs identifies novel loci associated with breast and ovarian cancer risk. (PubMed id 23544013)1 Couch F.J....Antoniou A.C. (2013)
    1004. RIF1 counteracts BRCA1-mediated end resection during D NA repair. (PubMed id 23486525)1 Feng L....Chen J. (2013)
    1005. Whole exome sequencing suggests much of non-BRCA1/BRCA 2 familial breast cancer is due to moderate and low penetrance susceptibility al leles. (PubMed id 23409019)1 Gracia-Aznarez F.J....Benitez J. (2013)
    1006. BRCA1/2 mutation screening in high-risk breast/ovarian cancer families and sporadic cancer patient surveilling for hidden high-risk fa milies. (PubMed id 23767878)1 Berzina D....Miklasevics E. (2013)
    1007. Implications of BRCA1 and BRCA2 mutations for the effi cacy of paclitaxel monotherapy in advanced ovarian cancer. (PubMed id 23265709)1 Tan D.S....Kaye S.B. (2013)
    1008. The penetrance of ductal carcinoma in situ among BRCA1 and BRCA2 mutation carriers. (PubMed id 23184082)1 Mazzola E....Parmigiani G. (2013)
    1009. Comparative in vitro and in silico analyses of variant s in splicing regions of BRCA1 and BRCA2 genes and characterization of novel pat hogenic mutations. (PubMed id 23451180)1 Colombo M....Radice P. (2013)
    1010. BRCA1, TP53, and CHEK2 germline mutations in uterine s erous carcinoma. (PubMed id 22811390)1 Pennington K.P....Swisher E.M. (2013)
    1011. BRCA1 expression and improved survival in ovarian canc er patients treated with intraperitoneal cisplatin and paclitaxel: a Gynecologic Oncology Group Study. (PubMed id 23462720)1 Lesnock J.L....Krivak T.C. (2013)
    1012. Evaluation of BRCA1 mutations in an unselected patient population with triple-negative breast cancer. (PubMed id 23192404)1 Rummel S....Ellsworth R.E. (2013)
    1013. HIF-1a overexpression in ductal carcinoma in situ of t he breast in BRCA1 and BRCA2 mutation carriers. (PubMed id 23409121)1 van der Groep P....van der Wall E. (2013)
    1014. BRCA1 germ-line mutations and tumor characteristics in eastern Chinese women with familial breast cancer. (PubMed id 23175448)1 Cao W....Li J.C. (2013)
    1015. Prevalence and type of BRCA mutations in Hispanics und ergoing genetic cancer risk assessment in the southwestern United States: a repo rt from the Clinical Cancer Genetics Community Research Network. (PubMed id 23233716)1 Weitzel J.N....Larson G.P. (2013)
    1016. BRCA1 immunohistochemistry in a molecularly characteri zed cohort of ovarian high-grade serous carcinomas. (PubMed id 23232854)1 Garg K....Soslow R.A. (2013)
    1017. BRCA1 mRNA expression as a predictive and prognostic m arker in advanced esophageal squamous cell carcinoma treated with cisplatin- or docetaxel-based chemotherapy/chemoradiotherapy. (PubMed id 23326344)1 Gao Y....Chen X. (2013)
    1018. A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. (PubMed id 23333306)1 Escribano-Diaz C....Durocher D. (2013)
    1019. ATR inhibition broadly sensitizes ovarian cancer cells to chemotherapy independent of BRCA status. (PubMed id 23548269)1 Huntoon C.J....Karnitz L.M. (2013)
    1020. Microenvironmental regulation of BRCA1 gene expression by c-Jun and Fra2 in premalignant human ovarian surface epithelial cells. (PubMed id 23339184)1 Zhou L....Roskelley C.D. (2013)
    1021. Methylation of breast cancer susceptibility gene 1 (BR CA1) predicts recurrence in patients with curatively resected stage I non-small cell lung cancer. (PubMed id 23335114)1 Harada H....Okada M. (2013)
    1022. Nitric oxide-dependent downregulation of BRCA1 express ion promotes genetic instability. (PubMed id 23108140)1 Yakovlev V.A. (2013)
    1023. Function of BRCA1 in the DNA damage response is mediat ed by ADP-ribosylation. (PubMed id 23680151)1 Li M. and Yu X. (2013)
    1024. TNRC9 downregulates BRCA1 expression and promotes brea st cancer aggressiveness. (PubMed id 23447579)1 Shan J....Chouchane L. (2013)
    1025. Impairment of BRCA1-related DNA double-strand break re pair leads to ovarian aging in mice and humans. (PubMed id 23408054)1 Titus S....Oktay K. (2013)
    1026. BRCA1 immunohistochemical staining as a prognostic ind icator in uterine serous carcinoma. (PubMed id 23221734)1 Beirne J.P....McCluggage W.G. (2013)
    1027. Haplotype analysis of the 185delAG BRCA1 mutation in e thnically diverse populations. (PubMed id 22763381)1 Laitman Y....Friedman E. (2013)
    1028. BRCA1, LMO4, and CtIP mRNA expression in erlotinib-tre ated non-small-cell lung cancer patients with EGFR mutations. (PubMed id 23407556)1 Karachaliou N....Rosell R. (2013)
    1029. Long-term ovarian cancer survival associated with muta tion in BRCA1 or BRCA2. (PubMed id 23257159)1 McLaughlin J.R....Narod S.A. (2013)
    1030. Screening for BRCA1 large genomic rearrangements in fe male Egyptian hereditary breast cancer patients. (PubMed id 23879077)1 Hagag E....El Wakil A. (2013)
    1031. Nrf2 is associated with the regulation of basal transc ription activity of the BRCA1 gene. (PubMed id 23353771)1 Wang Q....Jin W. (2013)
    1032. Frequency of premature menopause in women who carry a BRCA1 or BRCA2 mutation. (PubMed id 23414920)1 Finch A....Narod S. (2013)
    1033. The BRCA1 S1715N mutation segregates with breast and o varian cancer in an extended family pedigree. (PubMed id 22856468)1 Campbell J. and Speevak M.D. (2013)
    1034. BRG1 is required for formation of senescence-associate d heterochromatin foci induced by oncogenic RAS or BRCA1 loss. (PubMed id 23438604)1 Tu Z....Zhang R. (2013)
    1035. BRCA1 and ERCC1 mRNA levels are associated with lymph node metastasis in Chinese patients with colorectal cancer. (PubMed id 23496813)1 Yuanming L....Sanjun C. (2013)
    1036. Acetylation limits 53BP1 association with damaged chro matin to promote homologous recombination. (PubMed id 23377543)1 Tang J....Greenberg R.A. (2013)
    1037. Comprehensive analysis of BRCA1, BRCA2 and TP53 germli ne mutation and tumor characterization: a portrait of early-onset breast cancer in Brazil. (PubMed id 23469205)1 Carraro D.M....Brentani M.M. (2013)
    1038. Germline BRCA mutations are associated with higher ris k of nodal involvement, distant metastasis, and poor survival outcomes in prosta te cancer. (PubMed id 23569316)1 Castro E....Eeles R. (2013)
    1039. BRCA1 is a negative modulator of the PRC2 complex. (PubMed id 23624935)1 Wang L....Huang H. (2013)
    1040. The incidence of endometrial cancer in women with BRCA 1 and BRCA2 mutations: an international prospective cohort study. (PubMed id 23562522)1 Segev Y....Narod S.A. (2013)
    1041. Estimating survival rates after ovarian cancer among w omen tested for BRCA1 and BRCA2 mutations. (PubMed id 22680617)1 Narod S.A....McLaughlin J.R. (2013)
    1042. VEGF, HIF-1a expression and MVD as an angiogenic netwo rk in familial breast cancer. (PubMed id 23326384)1 Saponaro C....Mangia A. (2013)
    1043. Polymorphic repeat length in the AIB1 gene and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a meta-analysis of observation al studies. (PubMed id 23483928)1 Bianco A....Pavia M. (2013)
    1044. The deletion of exons 3-5 of BRCA1 is the first founde r rearrangement identified in breast and/or ovarian cancer Spanish families. (PubMed id 231173