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BRCA1 Gene

protein-coding   GIFtS: 72
GCID: GC17M041197

Breast Cancer 1, Early Onset

  See BRCA1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Breast Cancer 1, Early Onset1 2     BRCC12
RNF532 3     IRIS2
RING Finger Protein 532 3     PPP1R532
BROVCA12 5     BRCA1/BRCA2-Containing Complex, Subunit 12
PNCA42 5     Breast And Ovarian Cancer Susceptibility Protein 12
PSCP2 5     Breast And Ovarian Cancer Sususceptibility Protein 12
BRCA1/BRCA2-Containing Complex1     Breast Cancer Type 1 Susceptibility Protein2
Protein Phosphatase 11     Protein Phosphatase 1, Regulatory Subunit 532
Regulatory Subunit 531     EC 6.3.2.-3
Subunit 11     EC 6.3.28
BRCAI2     

External Ids:    HGNC: 11001   Entrez Gene: 6722   Ensembl: ENSG000000120487   OMIM: 1137055   UniProtKB: P383983   

Export aliases for BRCA1 gene to outside databases

Previous GC identifers: GC17P062255 GC17M043361 GC17M041105 GC17M041569 GC17M038450 GC17M036962


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BRCA1 Gene:
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as
a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal
transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance
complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also
interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of
double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of
inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a
role in modulating the subcellular localization and physiological function of this gene. Many alternatively
spliced transcript variants, some of which are disease-associated mutations, have been described for this gene,
but the full-length natures of only some of these variants has been described. A related pseudogene, which is
also located on chromosome 17, has been identified. (provided by RefSeq, May 2009)

GeneCards Summary for BRCA1 Gene:
BRCA1 (breast cancer 1, early onset) is a protein-coding gene. Diseases associated with BRCA1 include primary peritoneal carcinoma, and hereditary site-specific ovarian cancer syndrome. GO annotations related to this gene include RNA binding and enzyme binding.

UniProtKB/Swiss-Prot: BRCA1_HUMAN, P38398
Function: E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin
chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear
whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase
activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range
of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic
stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to
mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2
phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for
FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by
binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous
recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly
through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks.
Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on
DNA damage via BRCA1-mediated ubiquitination of RBBP8

Gene Wiki entry for BRCA1 (Talk:BRCA1) Gene

PharmGKB "VIP" summary for BRCA1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BRCA1 gene promoter:
         ATF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBRCA1 promoter sequence
   Search Chromatin IP Primers for BRCA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BRCA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.31

BRCA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRCA1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M041197:  view genomic region     (about GC identifiers)

Start:
41,196,312 bp from pter      End:
41,277,500 bp from pter
Size:
81,189 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: BRCA1_HUMAN, P38398 (See protein sequence)
Recommended Name: Breast cancer type 1 susceptibility protein  
Size: 1863 amino acids; 207721 Da
Subunit: Heterodimer with BARD1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains
BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the MRE11-RAD50-NBN protein (MRN) complex. This association could be
a dynamic process changing throughout the cell cycle and within subnuclear domains. Component of the BRCA1-A
complex, at least composed of the BRCA1, BARD1, UIMC1, BRCC3, BRE and BABAM1. Interacts (via the BRCT domains)
with FAM175A. Component of the BRCA1-RBBP8 complex. Interacts (via the BRCT domains) with RBBP8 ('Ser-327'
phosphorylated form); the interaction ubiquitinates RBBP8, regulates CHEK1 activation, and involves RBBP8 in
BRCA1-dependent G2/M checkpoint control on DNA damage. Associates with RNA polymerase II holoenzyme. Interacts
with SMC1A and COBRA1. Interacts (via BRCT domains) with BRIP1 (phosphorylated form). Interacts with FANCD2
(ubiquitinated form). Interacts with BAP1. Interacts with DCLRE1C and CLSPN. Interacts with H2AFX (phosphorylated
on 'Ser-140'). Interacts with CHEK1 and CHEK2. Interacts with BRCC3. Interacts (via the BRCT domains) with ACACA
(phosphorylated form); the interaction prevents dephosphorylation of ACACA. Interacts with AURKA. Interacts with
UBXN1. Part of a trimeric complex containing BRCA1, BRCA2 and PALB2. Interacts directly with PALB2; the
interaction is essential for its function in HRR. Interacts directly with BRCA2; the interaction occurs only in
the presence of PALB2 which serves as the bridging protein. Interacts (via the BRCT domains) with LMO4; the
interaction represses the transcriptional activity of BRCA1. Interacts with KIAA0101/PAF15
Sequence caution: Sequence=AAB61673.1; Type=Erroneous translation; Note=Wrong choice of CDS;
Selected PDB 3D structures from and Proteopedia for BRCA1 (see all 22):
1JM7 (3D)        1JNX (3D)        1N5O (3D)        1OQA (3D)        1T15 (3D)        1T29 (3D)    
Secondary accessions: O15129 Q3LRJ0 Q3LRJ6 Q6IN79 Q7KYU9
Alternative splicing, Alternative initiation: 6 isoforms:  P38398-1   P38398-2   P38398-3   P38398-4   P38398-5   P38398-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BRCA1: NX_P38398

Explore proteomics data for BRCA1 at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-308 by AURKA is required for normal cell cycle progression from G2 to mitosis.
    Phosphorylated in response to IR, UV, and various stimuli that cause checkpoint activation, probably by ATM or
    ATR. Phosphorylation at Ser-988 by CHEK2 regulates mitotic spindle assembly1
  • Autoubiquitinated, undergoes 'Lys-6'-linked polyubiquitination. 'Lys-6'-linked polyubiquitination does not promote
    degradation1
  • Ubiquitination2 at Lys987
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for BRCA1 (P38398) (see all 51)
     AKCSIKG  GRNHQGP  CPICLEL  ITKRSLQ 


    See BRCA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_009225.1  NP_009228.2  NP_009229.2  NP_009230.2  NP_009231.2  

    ENSEMBL proteins: 
     ENSP00000350283   ENSP00000417148   ENSP00000465818   ENSP00000467329   ENSP00000465347  
     ENSP00000418775   ENSP00000418960   ENSP00000418548   ENSP00000420705   ENSP00000419481  
     ENSP00000420412   ENSP00000418819   ENSP00000418212   ENSP00000417241   ENSP00000397145  
     ENSP00000419274   ENSP00000419988   ENSP00000420253   ENSP00000418986   ENSP00000419103  
     ENSP00000420201   ENSP00000417554   ENSP00000417988   ENSP00000420781   ENSP00000326002  
     ENSP00000312236   ENSP00000246907   ENSP00000338007   ENSP00000310938  
    Reactome Protein details: P38398

    BRCA1 Human Recombinant Protein Products:

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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BRCA1

     
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    antibodies-online proteins for BRCA1 (8 products) 

     
    antibodies-online peptides for BRCA1

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    EMD Millipore Mono- and Polyclonal Antibodies for the study of BRCA1
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    Novus Biologicals BRCA1 Antibodies
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    antibodies-online antibodies for BRCA1 (390 products) 

    BRCA1 Assay Products:

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    antibodies-online kits for BRCA1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 7):
     IPR001841 Znf_RING
     IPR011364 BRCA1
     IPR013083 Znf_RING/FYVE/PHD
     IPR017907 Znf_RING_CS
     IPR018957 Znf_C3HC4_RING-type

    Graphical View of Domain Structure for InterPro Entry P38398

    ProtoNet protein and cluster: P38398

    3 Blocks protein domains:
    IPB001357 BRCT domain
    IPB001841 Zn-finger
    IPB002378 Breast cancer type I susceptibility protein signature


    UniProtKB/Swiss-Prot: BRCA1_HUMAN, P38398
    Domain: The BRCT domains recognize and bind phosphorylated pSXXF motif on proteins. The interaction with the
    phosphorylated pSXXF motif of FAM175A/Abraxas, recruits BRCA1 at DNA damage sites
    Domain: The RING-type zinc finger domain interacts with BAP1
    Similarity: Contains 2 BRCT domains
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with BRCA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BRCA1_HUMAN, P38398
    Function: E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin
    chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear
    whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase
    activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range
    of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic
    stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to
    mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2
    phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for
    FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by
    binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous
    recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly
    through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks.
    Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on
    DNA damage via BRCA1-mediated ubiquitination of RBBP8
    Enzyme regulation: The E3 ubiquitin-protein ligase activity is inhibited by phosphorylation by AURKA. Activity is
    increased by phosphatase treatment

         Genatlas biochemistry entry for BRCA1:
    nuclear cell cycle regulated phosphoprotein of breast epithelium,located at the centrosome during M
    phase,associating with RAD51 (RECA) at S phase of mitosis,putative negative regulator of cell growth (in a
    RB-dependent fashion),phosphorylated by ATM protein kinase in response to ionizing radiation induced DNA
    damage,then activating DNA repair through homologous recombination in cooperation with BRCA2,RAD51 and
    RAD52,P-BRCA,also complexing with RNA polymerase II holoenzyme,may also regulate transcription,recruiting CREBBP
    and interacting with components of the histone deacetylase complex,mediating ubiquitin-conjugating enzyme
    (E2)-dependent ubiquitination through the RING finger domain,induction of BRCA1 triggers JNK/SAPK (MAPK8)
    dependent apoptosis through induction of DDIT1 (GADD45)

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS9662397
    GO:0003684damaged DNA binding ----
    GO:0003713transcription coactivator activity NAS15572661
    GO:0003723RNA binding IDA12419249
    GO:0004842contributes to ubiquitin-protein ligase activity IDA17349954
         
    Find genes that share ontologies with BRCA1           About GenesLikeMe


    Phenotypes:
         7 GenomeRNAi human phenotypes for BRCA1:
     Decreased homologous recombina  Decreased viability of wild-ty  Decreased viability with cispl  Increased G1 DNA content 
     Increased cell death HMECs cel  Synthetic lethal with cisplati  Upregulation of Wnt/beta-caten 

         Selected MGI mutant phenotypes (inferred from 21 alleles(MGI details for Brca1) (see all 23):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  mortality/aging  muscle 

    Find genes that share phenotypes with BRCA1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for BRCA1: Brca1tm2.1Cxd Brca1tm1Bhk Brca1tm1Mak Brca1tm1Rfo Brca1tm1.1Brn Brca1tm1Whl
                                                         Brca1tm1Cxd Brca1tm1Arge

       genOway: Develop your customized and physiologically relevant rodent model for BRCA1

    miRNA
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    miRTarBase miRNAs that target BRCA1:
    hsa-mir-193b-3p (MIRT016496), hsa-mir-21-5p (MIRT030886), hsa-mir-181a-5p (MIRT047335), hsa-mir-99b-3p (MIRT038534), hsa-mir-484 (MIRT042118), hsa-mir-192-5p (MIRT026534), hsa-mir-15a-5p (MIRT003333), hsa-mir-16-5p (MIRT003328), hsa-mir-212-3p (MIRT003967), hsa-mir-186-5p (MIRT044906), hsa-mir-335-5p (MIRT018119), hsa-mir-146a-5p (MIRT001920), hsa-mir-215-5p (MIRT024523), hsa-mir-24-3p (MIRT004836)

    Block miRNA regulation of human, mouse, rat BRCA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BRCA1 (see all 30):
    hsa-miR-4291 hsa-miR-3934 hsa-miR-520d-5p hsa-miR-125a-3p hsa-miR-522 hsa-miR-944 hsa-miR-450b-3p hsa-miR-132
    SwitchGear 3'UTR luciferase reporter plasmidBRCA1 3' UTR sequence
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    Addgene plasmids for BRCA1 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BRCA1_HUMAN, P38398: Nucleus. Chromosome (By similarity). Note=Localizes at sites of DNA damage at double-strand
    breaks (DSBs); recruitment to DNA damage sites is mediated by the BRCA1-A complex
    BRCA1_HUMAN, P38398: Isoform 3: Cytoplasm
    BRCA1_HUMAN, P38398: Isoform 5: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    plasma membrane4
    cytosol2
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex NAS14976165
    GO:0000793condensed chromosome ----
    GO:0000794condensed nuclear chromosome ----
    GO:0001726ruffle IDA--
    GO:0005634nucleus IDA17525340

    Find genes that share ontologies with BRCA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BRCA1 About   (see all 43)  
    See pathways by source

    SuperPathContained pathways About
    1Homologous Recombination Repair
    Homologous Recombination Repair0.70
    Recruitment of repair and signaling proteins to double-strand breaks0.00
    Double-Strand Break Repair0.70
    Homologous recombination repair of replication-independent double-strand breaks0.00
    ATM mediated response to DNA double-strand break0.31
    ATM mediated phosphorylation of repair proteins0.00
    2Meiosis (REACTOME)
    Meiosis0.74
    Meiotic Recombination0.74
    3Packaging Of Telomere Ends
    Meiotic Synapsis0.66
    Chromosome Maintenance0.62
    4Prostate Cancer
    Prostate Cancer0.32
    Integrated Cancer pathway0.32
    5Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    DNA Damage0.32


    Find genes that share SuperPaths with BRCA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for BRCA1 (see all 11)
        BRCA1 Pathway
    Molecular Mechanisms of Cancer
    JAK-STAT Pathway
    Estrogen Pathway
    DNA Damage Induced 14-3-3Sigma Signaling

    2 Cell Signaling Technology (CST) Pathways for BRCA1
        Cell Cycle / Checkpoint Control
    DNA Damage

    Selected GeneGo (Thomson Reuters) Pathways for BRCA1 (see all 8)
        DNA damage Role of Brca1 and Brca2 in DNA repair
    DNA damage ATM/ATR regulation of G1/S checkpoint
    DNA damage NHEJ mechanisms of DSBs repair
    Cell cycle Transition and termination of DNA replication
    Cell cycle Regulation of G1/S transition (part 1)

    Selected BioSystems Pathways for BRCA1 (see all 14)
        DNA damage response
    Integrated Breast Cancer Pathway
    Signaling Pathways in Glioblastoma
    Androgen receptor signaling pathway
    Integrated Pancreatic Cancer Pathway


    5 Reactome Pathways for BRCA1
        Meiotic synapsis
    Recruitment of repair and signaling proteins to double-strand breaks
    Fanconi Anemia pathway
    ATM mediated phosphorylation of repair proteins
    Meiotic recombination


    4 Kegg Pathways  (Kegg details for BRCA1):
        Fanconi anemia pathway
    Ubiquitin mediated proteolysis
    PI3K-Akt signaling pathway
    MicroRNAs in cancer

    UniProtKB/Swiss-Prot: BRCA1_HUMAN, P38398
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BRCA1 (see all 13): 

              Oncogenes & Tumor Suppressor Genes in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BRCA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BRCA1 (P383981, 2, 3 ENSP000003502834) via UniProtKB, MINT, STRING, and/or I2D (see all 387)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRIP1Q9BX631, 2, 3, ENSP000002590084EBI-349905,EBI-3509650 MINT-19306 MINT-19307 MINT-5115454 MINT-19369 MINT-5115319 MINT-5115375 MINT-5115552 MINT-19368 MINT-5115303 MINT-5115348 MINT-8141011 MINT-8140834 MINT-8140990 I2D: score=4 STRING: ENSP00000259008
    HIST1H4LP628052, 3, ENSP000003482584MINT-2490745 I2D: score=1 STRING: ENSP00000348258
    HIST1H4AP628052, 3MINT-2490745 I2D: score=1 
    HIST1H4BP628052, 3MINT-2490745 I2D: score=1 
    HIST1H4CP628052, 3MINT-2490745 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 47):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000724double-strand break repair via homologous recombination TAS--
    GO:0006260DNA replication ----
    GO:0006281DNA repair TAS--
    GO:0006301postreplication repair IDA17349954
    GO:0006302double-strand break repair TAS--

    Find genes that share ontologies with BRCA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BRCA1

    Selected Novoseek inferred chemical compound relationships for BRCA1 gene (see all 99)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 70.6 284 18377656 (7), 9655254 (7), 8895509 (5), 17505062 (4) (see all 99)
    tamoxifen 57 61 11710890 (7), 18997820 (6), 11870509 (4), 11130383 (4) (see all 29)
    progesterone 56.7 72 18197009 (4), 16109739 (4), 15816544 (3), 11981002 (2) (see all 42)
    mitomycin c 36.7 20 20174566 (3), 14751517 (3), 11406561 (2), 12007633 (1) (see all 9)
    cisplatin 32.9 95 16165098 (6), 19690636 (6), 19270496 (6), 18402708 (6) (see all 31)
    indole-3-carbinol 30.2 13 16434996 (5), 10868478 (2), 16152627 (1), 19622773 (1) (see all 5)
    docetaxel 21.8 23 18402708 (4), 18591931 (3), 19002265 (3), 11400119 (2) (see all 8)
    paclitaxel 21.5 35 16639080 (5), 12717416 (4), 19697632 (3), 19690636 (3) (see all 18)
    sodium bisulfite 20.9 2 17369979 (1), 15252835 (1)
    camptothecin 18.9 10 12955088 (2), 12007633 (1), 15258697 (1), 9679765 (1) (see all 6)



    Find genes that share compounds with BRCA1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for BRCA1 gene (12 alternative transcripts): 
    NM_007294.3  NM_007297.3  NM_007298.3  NM_007299.3  NM_007300.3  NM_007295.2  NM_007296.2  NM_007301.2  
    NM_007302.2  NM_007303.2  NM_007305.2  NM_007306.2  

    Unigene Cluster for BRCA1:

    Breast cancer 1, early onset
    Hs.194143  [show with all ESTs]
    Unigene Representative Sequence: NM_007300
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 31):
    ENST00000357654(uc010whl.2 uc010whm.2 uc002icp.4 uc010whp.2)
    ENST00000468300 ENST00000586385 ENST00000591534 ENST00000591849 ENST00000493795(uc010whq.1)
    ENST00000471181(uc002idc.1 uc010whr.1 uc010cyz.2 uc010cza.2 uc010wht.1)
    ENST00000461221(uc010cyy.1) ENST00000491747 ENST00000484087 ENST00000478531
    ENST00000493919 ENST00000472490 ENST00000487825 ENST00000461574 ENST00000467274(uc002idd.3 uc002ide.1)
    ENST00000412061(uc002icu.3 uc002ict.3 uc002icq.3) ENST00000470026

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat BRCA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BRCA1 (see all 30):
    hsa-miR-4291 hsa-miR-3934 hsa-miR-520d-5p hsa-miR-125a-3p hsa-miR-522 hsa-miR-944 hsa-miR-450b-3p hsa-miR-132
    SwitchGear 3'UTR luciferase reporter plasmidBRCA1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for BRCA1
    Predesigned siRNA for gene silencing in human, mouse, rat BRCA1
    Clone
    Products:
         
    OriGene clones in human, mouse for BRCA1 (see all 36)
    OriGene ORF clones in mouse, rat for BRCA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): BRCA1 (NM_007294)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BRCA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRCA1
    Addgene plasmids for BRCA1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for BRCA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BRCA1
      QuantiTect SYBR Green Assays in human, mouse, rat BRCA1
      QuantiFast Probe-based Assays in human, mouse, rat BRCA1
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12052 VA6-11284) for BRCA1 

    Additional mRNA sequence: 

    AB621825.1 AF005068.1 AK293762.1 AK307553.1 AK308084.1 AK316200.1 AY354539.2 AY751490.1 
    BC012577.1 BC030969.1 BC038947.1 BC046142.1 BC062429.1 BC072418.1 BC085615.1 BC106745.1 
    BC106746.1 BC114511.1 BC114562.1 BC115037.1 DQ333386.1 DQ333387.1 DQ363751.1 JN686490.1 
    NR_027676.1 U14680.1 U64805.1 U68041.1 Y08864.1 

    12 DOTS entries:

    DT.313524  DT.91764293  DT.100785659  DT.100785660  DT.100785657  DT.91764294  DT.102831055  DT.120969440 
    DT.86851763  DT.91764295  DT.426829  DT.95149213 

    Selected AceView cDNA sequences (see all 146):

    AL043576 AA486004 AW514868 BC072418 CB158976 BQ683955 BU155689 CB108172 
    BU147444 BM755305 CK822699 U14680 BQ681242 BC030969 BQ422380 CB136844 
    BU617173 BM755214 AU125312 CB155501 AA086435 BM988066 BQ215100 BC046142 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BRCA1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a ·
    SP1:                    -                                                                                         -                                             
    SP2:                                                  -                                                           -                                             
    SP3:                                                                                                  -     -     -                                             
    SP4:                    -                                                                             -     -     -                                             
    SP5:                                                                                -     -           -     -     -                                             

    ExUns: 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23
    SP1:  -                                             
    SP2:  -                                             
    SP3:  -                                             
    SP4:  -                                             
    SP5:  -                                             


    ECgene alternative splicing isoforms for BRCA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    BRCA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    BRCA1 Expression
    About this image


    BRCA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Primary Spermatocyte Seminiferous Tubules
     
     Gonad (Reproductive System)    fully expand to see all 2 entries
             Primordial Germ Cells Primitive Gonad
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
    BRCA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BRCA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.194143

    UniProtKB/Swiss-Prot: BRCA1_HUMAN, P38398
    Tissue specificity: Isoform 1 and isoform 3 are widely expressed. Isoform 3 is reduced or absent in several breast
    and ovarian cancer cell lines

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BRCA1 (see all 13): 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for BRCA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BRCA1
    QuantiTect SYBR Green Assays in human, mouse, rat BRCA1
    QuantiFast Probe-based Assays in human, mouse, rat BRCA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRCA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for BRCA1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Brca11 , 5 breast cancer 11, 5 74.24(n)1
    58.16(a)1
      11 (65.18 cM)5
    121891  NM_009764.31  NP_033894.31 
     1014887645 
    chicken
    (Gallus gallus)
    Aves BRCA11 breast cancer 1, early onset 54.18(n)
    40.73(a)
      373983  NM_204169.1  NP_989500.1 
    lizard
    (Anolis carolinensis)
    Reptilia BRCA16
    breast cancer 1, early onset
    37(a)
    1 ↔ 1
    6(62756363-62838799)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.121052 Xenopus laevis breast and ovarian cancer susceptibility more 79.05(n)    AF416868.1 


    ENSEMBL Gene Tree for BRCA1 (if available)
    TreeFam Gene Tree for BRCA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for BRCA1 gene
    10 SIMAP similar genes for BRCA1 using alignment to 67 protein entries:     BRCA1_HUMAN (see all proteins):
    TRIM40    TRIM5    SH3RF1    TRIM31    RAD18    TRIM26
    TRIM60    TRIM22    TRIM50    TRIM39

    Find genes that share paralogs with BRCA1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Polymorphic Variants from UniProtKB/Swiss-Prot
    BRCA1_HUMAN, P38398: There is evidence that the presence of the rare form of Gln-356-Arg and Leu-871-Pro polymorphisms
    may be associated with an increased risk for developing ovarian cancer


    Selected SNPs for BRCA1 (see all 3419)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs288976961,2,,4
    C,F,HBreast cancer (BC)4 untested142006029(-) AATTGA/C/TGGGAG 13 E A mis1 ese33NS NA 4706
    rs562141341,2,,4
    C,FBreast-ovarian cancer, familial, 1 (BROVCA1)4 untested142034059(-) GCTCAC/G/TGGTTA 16 H Q mis1 int11NA 4434
    rs803572721,2,,4
    CBreast cancer (BC)4 untested142034211(-) AGACAC/TCTGAT 11 P S nc-transcript-variantmis1 int11Minor allele frequency- T:0.01EA 120
    rs560463571,2,,4
    CBreast cancer (BC)4 untested142036276(-) ATATTA/TGGGAA 11 L F mis1 int10--------
    rs803572441,2,,4
    CBreast cancer (BC)4 untested142036848(-) TGCATA/C/GTGGAG 16 M L V nc-transcript-variantmis1 int10--------
    rs288976721,2,,4
    COvarian cancer (OC)4 other142048610(-) CACAGC/G/TGTCCT 20 R G C mis1 ese32NA 4
    VAR_0632124
    Breast cancer (BC)4--see VAR_0632122 M K mis40--------
    VAR_0077814
    Breast cancer (BC)4--see VAR_0077812 V A mis40--------
    VAR_0206974
    Breast-ovarian cancer, familial, 1 (BROVCA1)4--see VAR_0206972 R G mis40--------
    VAR_0077564
    Breast cancer (BC)4--see VAR_0077562 L S mis40--------

    HapMap Linkage Disequilibrium report for BRCA1 (41196312 - 41277500 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for BRCA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667044CNV Deletion23128226
    esv2672913CNV Deletion23128226
    esv2715952CNV Deletion23290073
    nsv457743CNV Loss19166990
    nsv470587CNV Loss18288195
    nsv908259CNV Loss21882294
    nsv827999CNV Loss20364138
    esv33998OTHER Inversion15654335

    Human Gene Mutation Database (HGMD): BRCA1
    Locus Specific Mutation Databases (LSDB): BRCA1

    3 Site Specific Mutation Identification with PCR Assays for BRCA1:
    Cosmic IdAA Change
    23943p.V757fs*8
    23941p.?
    13841p.L30F
    SeqTarget long-range PCR primers for resequencing BRCA1
    DNA2.0 Custom Variant and Variant Library Synthesis for BRCA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 113705   
    OMIM disorders: 604370  614320  
    UniProtKB/Swiss-Prot: BRCA1_HUMAN, P38398
  • Breast cancer (BC) [MIM:114480]: A common malignancy originating from breast epithelial tissue. Breast
    neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common
    type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated
    by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different
    families or even in the same case. Note=Disease susceptibility is associated with variations affecting the gene
    represented in this entry. Mutations in BRCA1 are thought to be responsible for 45% of inherited breast cancer.
    Moreover, BRCA1 carriers have a 4-fold increased risk of colon cancer, whereas male carriers face a 3-fold
    increased risk of prostate cancer. Cells lacking BRCA1 show defects in DNA repair by homologous recombination
  • Breast-ovarian cancer, familial, 1 (BROVCA1) [MIM:604370]: A condition associated with familial
    predisposition to cancer of the breast and ovaries. Characteristic features in affected families are an early age
    of onset of breast cancer (often before age 50), increased chance of bilateral cancers (cancer that develop in
    both breasts, or both ovaries, independently), frequent occurrence of breast cancer among men, increased
    incidence of tumors of other specific organs, such as the prostate. Note=Disease susceptibility is associated
    with variations affecting the gene represented in this entry. Mutations in BRCA1 are thought to be responsible
    for more than 80% of inherited breast-ovarian cancer
  • Ovarian cancer (OC) [MIM:167000]: The term ovarian cancer defines malignancies originating from ovarian
    tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the
    most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of
    late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry
  • Pancreatic cancer 4 (PNCA4) [MIM:614320]: A malignant neoplasm of the pancreas. Tumors can arise from
    both the exocrine and endocrine portions of the pancreas, but 95% of them develop from the exocrine portion,
    including the ductal epithelium, acinar cells, connective tissue, and lymphatic tissue. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry

  • Selected diseases for BRCA1 (see all 45):    
    About MalaCards
    primary peritoneal carcinoma    hereditary site-specific ovarian cancer syndrome    fallopian tube cancer    pancreatic cancer 4
    bilateral breast cancer    hereditary breast ovarian cancer    breast-ovarian cancer, familial, 1    brca1 hereditary breast and ovarian cancer
    breast cancer susceptibility    cystadenoma    male breast cancer    brca1 and brca2 hereditary breast and ovarian cancer
    adenocarcinoma, ovarian, somatic    brca2 hereditary breast and ovarian cancer    breast cancer, protection against    breast cancer, invasive ductal
    ovarian cystadenoma    peritoneal carcinoma    breast cancer, lobular    breast cancer, early-onset

    10 diseases from the University of Copenhagen DISEASES database for BRCA1:
    Ovarian cancer     Breast cancer     Fallopian tube cancer     Aplastic anemia
    Autosomal dominant disease     Peritoneal carcinoma     Carcinoma     Ataxia telangiectasia
    Ductal carcinoma in situ     Prostate cancer

    Find genes that share disorders with BRCA1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for BRCA1 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian cancer 95.8 2220 10560359 (7), 9796975 (7), 20223018 (7), 10978226 (6) (see all 99)
    breast cancer 93.5 4077 15564800 (9), 20223018 (9), 11710890 (8), 11044354 (8) (see all 99)
    germ-line mutation 91.3 221 17001151 (4), 8875917 (4), 10969800 (3), 16085232 (3) (see all 99)
    prophylactic oophorectomy 90.9 57 15863145 (6), 10469748 (5), 9148160 (3), 12023993 (3) (see all 39)
    bilateral breast cancer 85.2 38 11556836 (3), 10573018 (2), 17557253 (2), 19372713 (2) (see all 25)
    cancer 82.6 997 14966099 (7), 12237281 (5), 10972993 (4), 12237282 (4) (see all 99)
    breast carcinoma 75.1 214 9840533 (5), 9241077 (4), 9699523 (4), 11859870 (3) (see all 99)
    fanconis anemia 74.6 23 12483114 (2), 12967657 (2), 16116421 (2), 15726604 (1) (see all 19)
    tumors 73.4 1603 15868446 (10), 11773283 (8), 10686936 (8), 15712267 (7) (see all 99)
    ovarian carcinoma 72.7 115 10686936 (5), 16284991 (4), 10388472 (3), 9661879 (3) (see all 65)

    Genatlas disease: BRCA1
    breast carcinoma,early onset,high tumor grade,negative estrogen and progesterone receptor status,and high
    proliferative rate,breast ovarian cancer family,familial site-specific ovarian cancer,Lynch syndrome II (see
    TSG17B),excluding familial male breast cancer,including early onset gastric carcinoma,not frequently prostate
    carcinomas

    GeneTests: BRCA1
    GeneReviews: BRCA1
    Genetic Association Database (GAD): BRCA1
    Human Genome Epidemiology (HuGE) Navigator: BRCA1 (824 documents)
    Tumor Gene Database (TGDB): BRCA1

    Export disorders for BRCA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for BRCA1 gene, integrated from 10 sources (see all 3162) (see top 10):
    (articles sorted by number of sources associating them with BRCA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel germline mutations in the BRCA1 and BRCA2 genes in Indian breast and breast-ovarian cancer families. (PubMed id 14722926)1, 2, 4, 9 Valarmathi M.T.... Das S.N. (Hum. Mutat. 2004)
    2. One in 10 ovarian cancer patients carry germ line BRCA1 or BRCA2 mutations: results of a prospective study in Southern Sweden. (PubMed id 14746861)1, 2, 4, 9 Malander S.... Borg A. (Eur. J. Cancer 2004)
    3. BRCA1 and BRCA2 germline mutations in Korean patients with sporadic breast cancer. (PubMed id 15365993)1, 2, 4 Seo J.H.... Koo B.H. (Hum. Mutat. 2004)
    4. BRCA1 and BRCA2 mutations in women of different ethnicities undergoing testing for hereditary breast-ovarian cancer. (PubMed id 19241424)1, 4, 9 Hall M.J....Noll W.W. (Cancer 2009)
    5. [BRCA1 and BRCA2 mutations in families studied in the program of genetic counselling in cancer of the Valencian community (Spain)]. (PubMed id 18279628)1, 4, 9 Esteban CardeA+osa E....Salas Trejo D. (Med Clin (Barc) 2008)
    6. Mutations of the BRCA1 and BRCA2 genes in patients with bilateral breast cancer. (PubMed id 11556836)1, 4, 9 Steinmann D....DAPrk T. (Br. J. Cancer 2001)
    7. Is there any relationship between BRCA1 gene mutation and pancreatic cancer development? (PubMed id 19140568)1, 4, 9 Lawniczak M....StarzyA8ska T. (Pol. Arch. Med. Wewn. 2008)
    8. Evaluation of BRCA1 and BRCA2 mutations and risk-prediction models in a typical Asian country (Malaysia) with a relatively low incidence of breast cancer. (PubMed id 18627636)1, 4, 9 Thirthagiri E....Teo S.H. (Breast Cancer Res. 2008)
    9. Large genomic rearrangement in BRCA1 and BRCA2 and clinical characteristics of men with breast cancer in the United States. (PubMed id 17592676)1, 4, 9 Tchou J....Nathanson K.L. (Clin. Breast Cancer 2007)
    10. Population BRCA1 and BRCA2 mutation frequencies and cancer penetrances: a kin-cohort study in Ontario, Canada. (PubMed id 17148771)1, 4, 9 Risch H.A....Narod S.A. (J. Natl. Cancer Inst. 2006)
    11. A comprehensive model for familial breast cancer incorporating BRCA1, BRCA2 and other genes. (PubMed id 11857015)1, 4, 9 Antoniou A.C....Easton D.F. (Br. J. Cancer 2002)
    12. Frequency of BRCA1 and BRCA2 germline mutations in Japanese breast cancer families. (PubMed id 11149425)1, 4, 9 Ikeda N....Noguchi S. (Int. J. Cancer 2001)
    13. Novel germline mutations in breast cancer susceptibility genes BRCA1, BRCA2 and p53 gene in breast cancer patients from India. (PubMed id 15564800)1, 4, 9 Hedau S....Das B.C. (Breast Cancer Res. Treat. 2004)
    14. BRCA1 and BRCA2 germline mutation analysis among Indian women from south India: identification of four novel mutations and high-frequency occurrence of 185delAG mutation. (PubMed id 19805903)1, 4, 9 Vaidyanathan K....Somasundaram K. (J. Biosci. 2009)
    15. Contribution of BRCA1 and BRCA2 germline mutations to the incidence of early-onset breast cancer in Cyprus. (PubMed id 17250666)1, 4, 9 Loizidou M....Kyriacou K. (Clin. Genet. 2007)
    16. BRCA1, BRCA2 and TP53 mutations in very early-onset breast cancer with associated risks to relatives. (PubMed id 16644204)1, 4, 9 Lalloo F....Evans D.G. (Eur. J. Cancer 2006)
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    284. BRCA1-associated breast cancers present differently from BRCA2-associated and familial cases: long-term follow-up of the Dutch MRISC Screening Study. (PubMed id 21079137)1, 4 Rijnsburger A.J....Klijn J.G. (J. Clin. Oncol. 2010)
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    287. Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma in a pooled analysis of three studies. (PubMed id 20813000)1, 4 Shen M....Zheng T. (Br. J. Haematol. 2010)
    288. BRCA1 gene mutations may explain more than 80% of excess number of ovarian cancer cases after breast cancer - a population based study from the Western Sweden Health Care region. (PubMed id 20151938)1, 4 Einbeigi Z....Karlsson P. (Acta Oncol 2010)
    289. Incorporating tumour pathology information into breast cancer risk prediction algorithms. (PubMed id 20482762)1, 4 Mavaddat N....Antoniou A.C. (Breast Cancer Res. 2010)
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    291. Mutation scanning of exon 20 of the BRCA1 gene by high-resolution melting curve analysis. (PubMed id 19747471)1, 4 Vorkas P.A....Lianidou E.S. (Clin. Biochem. 2010)
    292. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    293. Single-nucleotide polymorphisms in the p53 pathway genes modify cancer risk in BRCA1 and BRCA2 carriers of Jewish-Ashkenazi descent. (PubMed id 20306497)1, 4 Yarden R.I....Papa M.Z. (Mol. Carcinog. 2010)
    294. Penetrance of breast cancer, ovarian cancer and contralateral breast cancer in BRCA1 and BRCA2 families: high cancer incidence at older age. (PubMed id 20204502)1, 4 van der Kolk D.M....Oosterwijk J.C. (Breast Cancer Res. Treat. 2010)
    295. A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population. (PubMed id 20852631)1, 4 Antoniou A.C....Couch F.J. (Nat. Genet. 2010)
    296. Pathologic complete response rates in young women with BRCA1-positive breast cancers after neoadjuvant chemotherapy. (PubMed id 20008645)1, 4 Byrski T....Narod S. (J. Clin. Oncol. 2010)
    297. Favourable ten-year overall survival in a Caucasian population with high probability of hereditary breast cancer. (PubMed id 20219108)1, 4 Cortesi L....Federico M. (BMC Cancer 2010)
    298. Breast cancer susceptibility variants alter risks in familial disease. (PubMed id 19617217)1, 4 Latif A....Newman W.G. (J. Med. Genet. 2010)
    299. The molecular pathogenesis of hereditary ovarian carcinoma: alterations in the tubal epithelium of women with BRCA1 and BRCA2 mutations. (PubMed id 20665887)1, 4 Norquist B.M....Swisher E.M. (Cancer 2010)
    300. Detection of splicing aberrations caused by BRCA1 and BRCA2 sequence variants encoding missense substitutions: implications for prediction of pathogenicity. (PubMed id 20513136)1, 2 Walker L.C....Spurdle A.B. (Hum. Mutat. 2010)
    301. Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women. (PubMed id 19950226)1, 4 Kontorovich T....Friedman E. (Int. J. Cancer 2010)
    302. Common breast cancer susceptibility alleles and the risk of breast cancer for BRCA1 and BRCA2 mutation carriers: implications for risk prediction. (PubMed id 21118973)1, 4 Antoniou A.C....Easton D.F. (Cancer Res. 2010)
    303. Impact of androgen receptor cytosine-adenine-guanine polymorphisms on clinical outcome in BRCA mutation-associated epithelial ovarian cancers. (PubMed id 19818997)1, 4 Li A.J....Karlan B.Y. (Gynecol. Oncol. 2010)
    304. BRCA1 mutations and colorectal cancer in Poland. (PubMed id 20862552)1, 4 Suchy J....Narod S.A. (Fam. Cancer 2010)
    305. A BRCA1 promoter variant (rs11655505) and breast cancer risk. (PubMed id 20413709)1, 4 Verderio P....Peterlongo P. (J. Med. Genet. 2010)
    306. Prevalence of BRCA1 and BRCA2 germ line mutations among women with carcinoma of the fallopian tube. (PubMed id 20570322)1, 4 Vicus D....Narod S.A. (Gynecol. Oncol. 2010)
    307. Alternative splicing and molecular characterization of splice site variants: BRCA1 c.591C&gt;T as a case study. (PubMed id 19892845)1, 4 Dosil V....de la Hoya M. (Clin. Chem. 2010)
    308. Smoking and the risk of breast cancer in BRCA1 and BRCA2 carriers: an update. (PubMed id 18483851)1, 4 Ginsburg O....Narod S.A. (Breast Cancer Res. Treat. 2009)
    309. Reproductive and hormonal factors, and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers: results from the International BRCA1/2 Carrier Cohort Study. (PubMed id 19190154)1, 4 Antoniou A.C....Goldgar D.E. (amp 2009)
    310. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)1, 4 Mavaddat N....Pharoah P.D. (amp 2009)
    311. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    312. Breast-conserving surgery in BRCA1/2 mutation carriers: are we approaching an answer? (PubMed id 19649554)1, 4 Garcia-Etienne C.A....Bonanni B. (Ann. Surg. Oncol. 2009)
    313. Evaluating the performance of models for predicting the BRCA germline mutations in Han Chinese familial breast cancer patients. (PubMed id 18807178)1, 4 Rao N.Y....Shao Z.M. (Breast Cancer Res. Treat. 2009)
    314. Polymorphisms in DNA repair and one-carbon metabolism genes and overall survival in diffuse large B-cell lymphoma and follicular lymphoma. (PubMed id 18830263)1, 4 Wang S.S....Cerhan J.R. (Leukemia 2009)
    315. Effects of the single nucleotide polymorphism at MDM2 309 on breast cancer patients with/without BRCA1/2 mutations. (PubMed id 19226467)1, 4 Nechushtan H....Peretz T. (BMC Cancer 2009)
    316. Clinicopathological study of male breast carcinoma: 24 years of experience. (PubMed id 19584580)1, 4 Shah P....Shah O. (Ann Saudi Med 2009)
    317. Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. (PubMed id 19237606)1, 4 Michiels S....Benhamou S. (Carcinogenesis 2009)
    318. Genetic mutations associated with cigarette smoking in pancreatic cancer. (PubMed id 19351817)1, 4 Blackford A....Hruban R.H. (Cancer Res. 2009)
    319. No evidence that CDKN1B (p27) polymorphisms modify breast cancer risk in BRCA1 and BRCA2 mutation carriers. (PubMed id 18543099)1, 4 Spurdle A.B....Chenevix-Trench G. (Breast Cancer Res. Treat. 2009)
    320. Penetrance of BRCA1/BRCA2 specific gene mutations in Iranian women with breast cancer. (PubMed id 19139771)1, 4 Hashemian A.H....Mehdipour P. (Saudi Med J 2009)
    321. Histopathological criteria and selection algorithms for BRCA1 genetic testing. (PubMed id 19215791)1, 4 Gadzicki D....Schlegelberger B. (Cancer Genet. Cytogenet. 2009)
    322. Cost-effectiveness of population-based BRCA1/2 testing and ovarian cancer prevention for Ashkenazi Jews: a call for dialogue. (PubMed id 19606050)1, 4 Rubinstein W.S....Rademaker A.W. (Genet. Med. 2009)
    323. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    324. Survival in Norwegian BRCA1 mutation carriers with breast cancer. (PubMed id 19366445)1, 4 Hagen A.I....ller P. (Hered Cancer Clin Pract 2009)
    325. [Mutations in the BRCA1 gene (185delAG and 5382insC) are not present in any of the 30 breast cancer patients analyzed from eastern Colombia]. (PubMed id 19753840)1, 4 Sanabria M.C....Vargas C.I. (Biomedica 2009)
    326. Advantages of the high resolution melting in the detection of BRCA1 or BRCA2 mutation carriers. (PubMed id 19616529)1, 4 JimAcnez I.d.e. .J....Bolufer Gilabert P. (Clin. Biochem. 2009)
    327. BRCA1/BRCA2 mutation status and clinical-pathologic features of 108 male breast cancer cases from Tuscany: a population-based study in central Italy. (PubMed id 18819001)1, 4 Ottini L....Palli D. (Breast Cancer Res. Treat. 2009)
    328. MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks. (PubMed id 19261746)1, 2 Shao G.... Greenberg R.A. (Genes Dev. 2009)
    329. BRCA1 breast cancer risk is modified by CYP19 polymorphisms in Ashkenazi Jews. (PubMed id 19366906)1, 4 Raskin L....Rennert G. (amp 2009)
    330. The contribution of founder mutations to early-onset breast cancer in French-Canadian women. (PubMed id 19863560)1, 4 Ghadirian P....Foulkes W.D. (Clin. Genet. 2009)
    331. Estimated risk of radiation-induced breast cancer from mammographic screening for young BRCA mutation carriers. (PubMed id 19176458)1, 4 Berrington de Gonzalez A....Robson M. (J. Natl. Cancer Inst. 2009)
    332. Common variants in immune and DNA repair genes and risk for human papillomavirus persistence and progression to cervical cancer. (PubMed id 19012493)1, 4 Wang S.S....Hildesheim A. (J. Infect. Dis. 2009)
    333. Assessing the usefulness of a novel MRI-based breast density estimation algorithm in a cohort of women at high genetic risk of breast cancer: the UK MARIBS study. (PubMed id 19903338)1, 4 Thompson D.J....Warren R.M. (Breast Cancer Res. 2009)
    334. Age-dependent penetrance of different germline mutations in the BRCA1 gene. (PubMed id 19329713)1, 4 Al-Mulla F....Taylor G.T. (J. Clin. Pathol. 2009)
    335. The TP53 Arg72Pro and MDM2 309G&gt;T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers. (PubMed id 19707196)1, 4 Sinilnikova O.M....Stoppa-Lyonnet D. (Br. J. Cancer 2009)
    336. Clinical and pathologic differences between BRCA1-, BRCA2-, and non-BRCA-associated breast cancers in a multiracial developing country. (PubMed id 19649760)1, 4 Yip C.H....Teo S.H. (World J Surg 2009)
    337. Modification of ovarian cancer risk by BRCA1/2-interacting genes in a multicenter cohort of BRCA1/2 mutation carriers. (PubMed id 19584272)1, 4 Rebbeck T.R....Daly M.B. (Cancer Res. 2009)
    338. A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers. (PubMed id 19789190)1, 4 Young R.P....Gamble G.D. (Postgrad Med J 2009)
    339. Evidence for an ancient BRCA1 mutation in breast cancer patients of Yoruban ancestry. (PubMed id 18679828)1, 4 Zhang B....Olopade O.I. (Fam. Cancer 2009)
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    341. Ovarian epithelial dysplasia and prophylactic oophorectomy for genetic risk. (PubMed id 19258944)1, 4 ChA-ne G....Dauplat J. (Int. J. Gynecol. Cancer 2009)
    342. The BRCA1 3'-UTR: 5711+421T/T_5711+1286T/T genotype is a possible breast and ovarian cancer risk factor. (PubMed id 19405875)1, 4 Pongsavee M....Patmasiriwat P. (Genet Test Mol Biomarkers 2009)
    343. Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk. (PubMed id 19690177)1, 4 McWilliams R.R....Petersen G.M. (amp 2009)
    344. Evaluation of a breast/ovarian cancer genetics referral screening tool in a mammography population. (PubMed id 19752737)1, 4 Bellcross C.A....Meisner L.T. (Genet. Med. 2009)
    345. Molecular genetics analysis of hereditary breast and ovarian cancer patients in India. (PubMed id 19656415)1, 4 Soumittra N....Rajkumar T. (Hered Cancer Clin Pract 2009)
    346. Oral contraceptive use and BRCA penetrance: a case-only study. (PubMed id 19549808)1, 4 Pasanisi P....Berrino F. (amp 2009)
    347. Genotyping of frequent BRCA1/2 SNPs with unlabeled probes: a supplement to HRMCA mutation scanning, allowing the strong reduction of sequencing burden. (PubMed id 19644020)1, 4 De Leeneer K....Claes K. (J Mol Diagn 2009)
    348. Genetic contribution to all cancers: the first demonstration using the model of breast cancers from Poland stratified by age at diagnosis and tumour pathology. (PubMed id 18415014)1, 4 LubiA8ski J....Scott R. (Breast Cancer Res. Treat. 2009)
    349. Genetic variation in immune regulation and DNA repair pathways and stomach cancer in China. (PubMed id 19661089)1, 4 Hussain S.K....Zhang Z.F. (amp 2009)
    350. Elevated level of 8-oxo-7,8-dihydro-2'-deoxyguanosine in leukocytes of BRCA1 mutation carriers compared to healthy controls. (PubMed id 19623658)1, 4 Dziaman T....Olinski R. (Int. J. Cancer 2009)
    351. Absence of founder BRCA1 and BRCA2 mutations in cutaneous malignant melanoma patients of Ashkenazi origin. (PubMed id 18679827)1, 4 Kadouri L....Lotem M. (Fam. Cancer 2009)
    352. NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. (PubMed id 19261749)1, 2 Wang B.... Elledge S.J. (Genes Dev. 2009)
    353. [Detection of 5382insC mutation in human BRCA1 gene using fluorescent labeled oligonucleotides]. (PubMed id 20088375)1, 4 Mitrofanov D.V....Liakhovich V.V. (Mol. Biol. (Mosk.) 2009)
    354. A polymorphism in Werner syndrome gene is associated with breast cancer susceptibility in Chinese women. (PubMed id 19205873)1, 4 Wang Z....Shen H. (Breast Cancer Res. Treat. 2009)
    355. A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility. (PubMed id 19116388)1, 4 Vineis P....Matullo G. (J. Natl. Cancer Inst. 2009)
    356. Role of BRCA2 mutation status on overall survival among breast cancer patients from Sardinia. (PubMed id 19232099)1, 4 Budroni M....Palmieri G. (BMC Cancer 2009)
    357. Functional polymorphisms in the BRCA1 promoter influence transcription and are associated with decreased risk for breast cancer in Chinese women. (PubMed id 18782836)1, 4 Chan K.Y....Khoo U.S. (J. Med. Genet. 2009)
    358. Mutational analysis of BRCA1 and BRCA2 genes in Mexican breast cancer patients. (PubMed id 19899408)1, 4 Vidal-MillA!n S....DueA+as-GonzA!lez A. (Eur. J. Gynaecol. Oncol. 2009)
    359. Use of total abdominal hysterectomy and hormone replacement therapy in BRCA1 and BRCA2 mutation carriers undergoing risk-reducing salpingo-oophorectomy. (PubMed id 18758995)1, 4 Gabriel C.A....Domchek S.M. (Fam. Cancer 2009)
    360. BRCA1 and BRCA2 germline mutations in Korean ovarian cancer patients. (PubMed id 19499246)1, 4 Lim M.C....Park S.Y. (J. Cancer Res. Clin. Oncol. 2009)
    361. Novel and common BRCA1 mutations in familial breast/ovarian cancer patients from Lithuania. (PubMed id 18763032)1, 4 Janavicius R....Kucinskas V. (Breast Cancer Res. Treat. 2009)
    362. Breast cancer in young women (YBC): prevalence of BRCA1/2 mutations and risk of secondary malignancies across diverse racial groups. (PubMed id 19491284)1, 4 Haffty B.G....Moran M.S. (Ann. Oncol. 2009)
    363. The prevalence of BRCA1 mutations among young women with triple-negative breast cancer. (PubMed id 19298662)1, 4 Young S.R....Narod S.A. (BMC Cancer 2009)
    364. No association of TGFB1 L10P genotypes and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a multi-center cohort study. (PubMed id 18523885)1, 4 Rebbeck T.R....Easton D.F. (Breast Cancer Res. Treat. 2009)
    365. Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array. (PubMed id 19536092)1, 4 Kweekel D.M....Guchelaar H.J. (Br. J. Cancer 2009)
    366. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PubMed id 18950845)1, 4 Vega A....Carracedo A. (Gynecol. Oncol. 2009)
    367. A method to assess the clinical significance of unclassified variants in the BRCA1 and BRCA2 genes based on cancer family history. (PubMed id 19200354)1, 4 GA^mez GarcA-a E.B....Vreeswijk M.P. (Breast Cancer Res. 2009)
    368. Common genetic variants in candidate genes and risk of familial lymphoid malignancies. (PubMed id 19573080)1, 4 Liang X.S....Goldin L.R. (Br. J. Haematol. 2009)
    369. Diagnostic guidelines for high-resolution melting curve (HRM) analysis: an interlaboratory validation of BRCA1 mutation scanning using the 96-well LightScanner. (PubMed id 19370767)1, 4 van der Stoep N....Bakker E. (Hum. Mutat. 2009)
    370. Prevalence of BRCA1 and BRCA2 gene mutations in families with medium and high risk of breast and ovarian cancer in Brazil. (PubMed id 19377795)1, 4 Esteves V.F....Vieira R.J. (Braz. J. Med. Biol. Res. 2009)
    371. MERIT40 facilitates BRCA1 localization and DNA damage repair. (PubMed id 19261748)1, 2 Feng L.... Chen J. (Genes Dev. 2009)
    372. Breast cancer risk in relation to the joint effect of BRCA mutations and diet diversity. (PubMed id 19165595)1, 4 Ghadirian P....Nkondjock A. (Breast Cancer Res. Treat. 2009)
    373. A role of BRCA1 and BRCA2 germline mutations in breast cancer susceptibility within Sardinian population. (PubMed id 19619314)1, 4 Palomba G....Monne M. (BMC Cancer 2009)
    374. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    375. Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies. (PubMed id 19956635)1, 4 Holmes M.V....Casas J.P. (PLoS ONE 2009)
    376. Candidate serous cancer precursors in fallopian tube epithelium of BRCA1/2 mutation carriers. (PubMed id 19543244)1, 4 Shaw P.A....Begley H. (Mod. Pathol. 2009)
    377. Screening for familial ovarian cancer: poor survival of BRCA1/2 related cancers. (PubMed id 18413372)1, 4 Evans D.G....Moller P. (J. Med. Genet. 2009)
    378. High-resolution melting analysis for rapid screening of BRCA1 and BRCA2 Spanish mutations. (PubMed id 18528753)1, 4 de Juan I....Bolufer P. (Breast Cancer Res. Treat. 2009)
    379. PALB2 is an integral component of the BRCA complex required for homologous recombination repair. (PubMed id 19369211)1, 2 Sy S.M.... Chen J. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    380. Evaluation of a candidate breast cancer associated SNP in ERCC4 as a risk modifier in BRCA1 and BRCA2 mutation carriers. Results from the Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA). (PubMed id 19920816)1, 4 Osorio A....BenA-tez J. (Br. J. Cancer 2009)
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    382. Distant disease-free interval, site of first relapse and post-relapse survival in BRCA1- and BRCA2-associated compared to sporadic breast cancer patients. (PubMed id 17952592)1, 4 Kriege M....Klijn J.G. (Breast Cancer Res. Treat. 2008)
    383. Polymorphisms in DNA repair genes, ionizing radiation exposure and risk of breast cancer in U.S. Radiologic technologists. (PubMed id 17764108)1, 4 Bhatti P....Sigurdson A.J. (Int. J. Cancer 2008)
    384. Asymmetric real-time PCR detection of BRCA1 5382insC mutation by melting curve analysis in the LightCycler. (PubMed id 18242166)1, 4 Kroupis C....Lianidou E.S. ( international journal of clinical chemistry 2008)
    385. Screening for ATM sequence alterations in African-American women diagnosed with breast cancer. (PubMed id 17333338)1, 4 Hirsch A.E....Rosenstein B.S. (Breast Cancer Res. Treat. 2008)
    386. Effect of BRCA1 haplotype on survival of non-small-cell lung cancer patients treated with platinum-based chemotherapy. (PubMed id 19018088)1, 4 Kim H.T....Ryu J.S. (J. Clin. Oncol. 2008)
    387. Contribution of BRCA1 germline mutation in patients with sporadic breast cancer. (PubMed id 18759965)1, 4 Malik F.A....Sadiq R. (Int Semin Surg Oncol 2008)
    388. Better life expectancy in women with BRCA2 compared with BRCA1 mutations is attributable to lower frequency and later onset of ovarian cancer. (PubMed id 18559571)1, 4 Byrd L.M....Evans G.D. (amp 2008)
    389. Prolactin levels, breast-feeding and milk production in a cohort of young healthy women from high-risk breast cancer families: implications for breast cancer risk. (PubMed id 18080788)1, 4 Hietala M....JernstrAPm H. (Fam. Cancer 2008)
    390. Effect of BRCA1/2 mutations on long-term survival of patients with invasive ovarian cancer: the national Israeli study of ovarian cancer. (PubMed id 18165636)1, 4 Chetrit A....Sadetzki S. (J. Clin. Oncol. 2008)
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    392. The influence of genetic variation in 30 selected genes on the clinical characteristics of early onset breast cancer. (PubMed id 19094228)1, 4 Tapper W....Eccles D. (Breast Cancer Res. 2008)
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    394. High risk for ovarian cancer in a prospective series is restricted to BRCA1/2 mutation carriers. (PubMed id 19010876)1, 4 Maehle L....ller P. (Clin. Cancer Res. 2008)
    395. New sequence variants in BRCA1 and BRCA2 genes detected by high-resolution melting analysis in an elderly healthy female population in Croatia. (PubMed id 18844490)1, 4 Cvok M.L....Levanat S. (Clin. Chem. Lab. Med. 2008)
    396. Cross-sectional analysis of germline BRCA1 and BRCA2 mutations in Japanese patients suspected to have hereditary breast/ovarian cancer. (PubMed id 19016756)1, 4 Sugano K....Miki Y. (Cancer Sci. 2008)
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    398. Results of a population-based screening for hereditary breast cancer in a region of North-Central Italy: contribution of BRCA1/2 germ-line mutations. (PubMed id 18092194)1, 4 Seymour I.J....Calistri D. (Breast Cancer Res. Treat. 2008)
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    400. Greek BRCA1 and BRCA2 mutation spectrum: two BRCA1 mutations account for half the carriers found among high-risk breast/ovarian cancer patients. (PubMed id 17453335)1, 4 Konstantopoulou I....Yannoukakos D. (Breast Cancer Res. Treat. 2008)
    401. Impaired tamoxifen metabolism reduces survival in familial breast cancer patients. (PubMed id 18794105)1, 4 Newman W.G....Evans D.G. (Clin. Cancer Res. 2008)
    402. A BRCA1 mutation is not associated with increased indicators of oxidative stress. (PubMed id 19073505)1, 4 Kotsopoulos J....Narod S.A. (Clin. Breast Cancer 2008)
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    406. Disease family history and modification of breast cancer risk in common BRCA2 variants. (PubMed id 18288416)1, 4 Seymour I.J....Calistri D. (Oncol. Rep. 2008)
    407. Spectrum and characterisation of BRCA1 and BRCA2 deleterious mutations in high-risk Czech patients with breast and/or ovarian cancer. (PubMed id 18489799)1, 4 Machackova E....Claes K. (BMC Cancer 2008)
    408. Power spectral analysis of mammographic parenchymal patterns for breast cancer risk assessment. (PubMed id 18175183)1, 4 Li H....Chinander M.R. (J Digit Imaging 2008)
    409. Pathogenicity of the BRCA1 missense variant M1775K is determined by the disruption of the BRCT phosphopeptide-binding pocket: a multi- modal approach. (PubMed id 18285836)1, 2 Tischkowitz M.... Foulkes W.D. (Eur. J. Hum. Genet. 2008)
    410. RASSF1A polymorphism A133S is associated with early onset breast cancer in BRCA1/2 mutation carriers. (PubMed id 18172292)1, 4 Gao B....Minna J.D. (Cancer Res. 2008)
    411. Infertility, treatment of infertility, and the risk of breast cancer among women with BRCA1 and BRCA2 mutations: a case-control study. (PubMed id 18509731)1, 4 Kotsopoulos J....Narod S.A. (amp 2008)
    412. Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers. (PubMed id 18095154)1, 4 Walker L.C....Spurdle A.B. (Breast Cancer Res. Treat. 2008)
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    414. Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. (PubMed id 19064572)1, 4 Palmieri R.T.... . (amp 2008)
    415. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    416. MDM2 SNP309 accelerates breast and ovarian carcinogenesis in BRCA1 and BRCA2 carriers of Jewish-Ashkenazi descent. (PubMed id 18026875)1, 4 Yarden R.I....Papa M.Z. (Breast Cancer Res. Treat. 2008)
    417. CHEK2*1100delC genotyping for clinical assessment of breast cancer risk: meta-analyses of 26,000 patient cases and 27,000 controls. (PubMed id 18172190)1, 4 Weischer M....Nordestgaard B.G. (J. Clin. Oncol. 2008)
    418. Methionine-dependence phenotype in the de novo pathway in BRCA1 and BRCA2 mutation carriers with and without breast cancer. (PubMed id 18842997)1, 4 Beetstra S....Fenech M. (amp 2008)
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    420. Pleomorphic adenoma of salivary glands does not appear to be a BRCA-1-dependent tumour in a Polish cohort. (PubMed id 19031948)1, 4 LubiA8ski J....LubiA8ski J. (Anticancer Res. 2008)
    421. MLPA screening in the BRCA1 gene from 1,506 German hereditary breast cancer cases: novel deletions, frequent involvement of exon 17, and occurrence in single early-onset cases. (PubMed id 18431737)1, 4 Engert S....Meindl A. (Hum. Mutat. 2008)
    422. Ovarian cancer risk in Polish BRCA1 mutation carriers is not associated with the prohibitin 3' untranslated region polymorphism. (PubMed id 18397521)1, 4 Jakubowska A....Hamann U. (BMC Cancer 2008)
    423. &quot;BRCAness&quot; syndrome in ovarian cancer: a case-control study describing the clinical features and outcome of patients with epithelial ovarian cancer associated with BRCA1 and BRCA2 mutations. (PubMed id 18955455)1, 4 Tan D.S....Gore M.E. (J. Clin. Oncol. 2008)
    424. Smoking and risk of breast cancer in carriers of mutations in BRCA1 or BRCA2 aged less than 50 years. (PubMed id 17972172)1, 4 (Breast Cancer Res. Treat. 2008)
    425. Pathway analysis of single-nucleotide polymorphisms potentially associated with glioblastoma multiforme susceptibility using random forests. (PubMed id 18559551)1, 4 Chang J.S....Wrensch M.R. (amp 2008)
    426. Predictive genetic testing for BRCA1/2 in a UK clinical cohort: three-year follow-up. (PubMed id 17285126)1, 4 Foster C....Evans D.G. (Br. J. Cancer 2007)
    427. CCDC98 targets BRCA1 to DNA damage sites. (PubMed id 17643121)1, 2 Liu Z.... Yu X. (Nat. Struct. Mol. Biol. 2007)
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    429. Clinical outcomes of breast cancer in carriers of BRCA1 and BRCA2 mutations. (PubMed id 17625123)1, 4 Rennert G....Narod S.A. (N. Engl. J. Med. 2007)
    430. Absence of the common IGF1 19 CA-repeat allele is more common among BRCA1 mutation carriers than among non-carriers from BRCA1 families. (PubMed id 17484040)1, 4 Henningson M....JernstrAPm H. (Fam. Cancer 2007)
    431. Founder mutations in early-onset, familial and bilateral breast cancer patients from Russia. (PubMed id 17333477)1, 4 Sokolenko A.P....Imyanitov E.N. (Fam. Cancer 2007)
    432. Meta-analysis of BRCA1 and BRCA2 penetrance. (PubMed id 17416853)1, 4 Chen S. and Parmigiani G. (J. Clin. Oncol. 2007)
    433. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)1, 2 Matsuoka S.... Elledge S.J. (Science 2007)
    434. A systematic genetic assessment of 1,433 sequence variants of unknown clinical significance in the BRCA1 and BRCA2 breast cancer- predisposition genes. (PubMed id 17924331)1, 2 Easton D.F.... Goldgar D.E. (Am. J. Hum. Genet. 2007)
    435. 655Val and 1170Pro ERBB2 SNPs in familial breast cancer risk and BRCA1 alterations. (PubMed id 17452776)1, 4 Tommasi S....Paradiso A. (Cell. Oncol. 2007)
    436. Multiplex SNaPshot for detection of BRCA1/2 common mutations in Spanish and Spanish related breast/ovarian cancer families. (PubMed id 17603881)1, 4 Filippini S....Vega A. (BMC Med. Genet. 2007)
    437. Lymphocyte radiosensitivity in BRCA1 and BRCA2 mutation carriers and implications for breast cancer susceptibility. (PubMed id 17582599)1, 4 Barwell J....Hodgson S.V. (Int. J. Cancer 2007)
    438. Polymorphism in nucleotide excision repair gene XPC correlates with bleomycin-induced chromosomal aberrations. (PubMed id 17685459)1, 4 Laczmanska I....Sasiadek M.M. (Environ. Mol. Mutagen. 2007)
    439. Prognosis of early-onset breast cancer based on BRCA1/2 mutation status in a French population-based cohort and review. (PubMed id 17061047)1, 4 Bonadona V....Lasset C. (Breast Cancer Res. Treat. 2007)
    440. This article was published online in error and has been removed by the publisher. (PubMed id 17409195)1, 4 (Hum. Mol. Genet. 2007)
    441. Methyl group metabolism gene polymorphisms as modifier of breast cancer risk in Italian BRCA1/2 carriers. (PubMed id 17151928)1, 4 Pepe C....Caligo M.A. (Breast Cancer Res. Treat. 2007)
    442. CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response. (PubMed id 17643122)1, 2 Kim H.... Chen J. (Nat. Struct. Mol. Biol. 2007)
    443. BRCA1 disease-associated haplotypes in Singapore Malay women with early-onset breast/ovarian cancer. (PubMed id 17406974)1, 4 Ali A.B....Sng J.H. (Breast Cancer Res. Treat. 2007)
    444. [Several risk factors of breast cancer development and prognosis of its course]. (PubMed id 18663943)1, 4 Dovzhenko S.P....Gorovenko N.G. (Lik. Sprava 2007)
    445. High prevalence of BRCA1 deletions in BRCAPRO-positive patients with high carrier probability. (PubMed id 17591842)1, 4 Veschi S....Stuppia L. (Ann. Oncol. 2007)
    446. BRCA mutations in women with ductal carcinoma in situ. (PubMed id 17634561)1, 4 Smith K.L....Robson M. (Clin. Cancer Res. 2007)
    447. Prediction of BRCA1/2 mutation status in patients with ovarian cancer from a hospital-based cohort. (PubMed id 17413421)1, 4 Jacobi C.E....Kenter G.G. (Genet. Med. 2007)
    448. The impact of BRCA1 on spina bifida meningomyelocele lesions. (PubMed id 17640328)1, 4 King T.M....Northrup H. (Ann. Hum. Genet. 2007)
    449. CYP17 genotype is associated with short menstrual cycles, early oral contraceptive use and BRCA mutation status in young healthy women. (PubMed id 17307805)1, 4 Henningson M....JernstrAPm H. (Mol. Hum. Reprod. 2007)
    450. AURKA F31I polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a consortium of investigators of modifiers of BRCA1/2 study. (PubMed id 17627006)1, 4 Couch F.J....Antoniou A.C. (amp 2007)
    451. Prevalence of pathogenic BRCA1 mutation carriers in 5 US racial/ethnic groups. (PubMed id 18159056)1, 4 John E.M....Whittemore A.S. (JAMA 2007)
    452. BRCA1 and BRCA2 germline mutations in Korean breast cancer patients at high risk of carrying mutations. (PubMed id 16455195)1, 4 Ahn S.H....Cho D.Y. (Cancer Lett. 2007)
    453. [Study of BRCA1 and BRCA2 gene mutations in human sporadic breast cancers]. (PubMed id 17686308)1, 4 Zhang H.T....Wan F.Q. (Zhonghua Wai Ke Za Zhi 2007)
    454. BRCA1 and BRCA2 genetic testing in Hispanic patients: mutation prevalence and evaluation of the BRCAPRO risk assessment model. (PubMed id 17925560)1, 4 Vogel K.J....Arun B. (J. Clin. Oncol. 2007)
    455. Improved survival in BRCA2 carriers with ovarian cancer. (PubMed id 17160431)1, 4 Pal T....Sutphen R. (Fam. Cancer 2007)
    456. BRCA1 and BRCA2 germline mutation analysis in the Indonesian population. (PubMed id 17972177)1, 4 Purnomosari D....van Diest P.J. (Breast Cancer Res. Treat. 2007)
    457. High incidence of mutations in BRCA1 and BRCA2 genes in ovarian cancer. (PubMed id 18256760)1, 4 Smirnova T.Y....Karpukhin A.V. (Bull. Exp. Biol. Med. 2007)
    458. Germline mutations in the breast cancer susceptibility gene PTEN are rare in high-risk non-BRCA1/2 French Canadian breast cancer families. (PubMed id 17636424)1, 4 GuAcnard F....Durocher F. (Fam. Cancer 2007)
    459. BRCA1 genetic testing in 106 breast and ovarian cancer families from Southern Italy (Sicily): a mutation analyses. (PubMed id 17221156)1, 4 Russo A....Bazan V. (Breast Cancer Res. Treat. 2007)
    460. Differences in the frequency and distribution of BRCA1 and BRCA2 mutations in breast/ovarian cancer cases from the Basque country with respect to the Spanish population: implications for genetic counselling. (PubMed id 17262179)1, 4 Beristain E....Tejada M.I. (Breast Cancer Res. Treat. 2007)
    461. Ductal carcinoma in situ in BRCA mutation carriers. (PubMed id 17210933)1, 4 Hwang E.S....Ziegler J.L. (J. Clin. Oncol. 2007)
    462. Oral contraceptives and breast cancer risk in the international BRCA1/2 carrier cohort study: a report from EMBRACE, GENEPSO, GEO-HEBON, and the IBCCS Collaborating Group. (PubMed id 17635951)1, 4 Brohet R.M....Rookus M.A. (J. Clin. Oncol. 2007)
    463. Acute chemotherapy-related toxicity is not increased in BRCA1 and BRCA2 mutation carriers treated for breast cancer in the United Kingdom. (PubMed id 17145825)1, 4 Shanley S....Eeles R. (Clin. Cancer Res. 2006)
    464. Insulin-like growth factor-1 genotype predicts breast volume after pregnancy and hormonal contraception and is associated with circulating insulin-like growth factor-1 levels: implications for risk of early-onset breast cancer in young women from hereditary breast cancer families. (PubMed id 17010055)1, 4 JernstrAPm H....Olsson H. (Int. J. Gynecol. Cancer 2006)
    465. Are CYP17 genotypes a biomarker for ovarian cancer in patients with cancer history in their family? (PubMed id 16783967)1, 4 Yazici H....Dalay N. (Oncol. Res. 2006)
    466. Prevalence and predictors of BRCA1 and BRCA2 mutations in a population-based study of breast cancer in white and black American women ages 35 to 64 years. (PubMed id 16912212)1, 4 Malone K.E....Ostrander E.A. (Cancer Res. 2006)
    467. Pregnancies, breast-feeding, and breast cancer risk in the International BRCA1/2 Carrier Cohort Study (IBCCS). (PubMed id 16622123)1, 4 Andrieu N.... . (J. Natl. Cancer Inst. 2006)
    468. Racial differences in the incidence of BRCA1 and BRCA2 mutations in a cohort of early onset breast cancer patients: African American compared to white women. (PubMed id 15983021)1, 4 Haffty B.G....Lannin D. (J. Med. Genet. 2006)
    469. High frequency of BRCA1 5382insC mutation in Russian breast cancer patients. (PubMed id 16737811)1, 4 Sokolenko A.P....Imyanitov E.N. (Eur. J. Cancer 2006)
    470. BRCA1-positive breast cancers in young women from Poland. (PubMed id 16541315)1, 4 LubiA8ski J....Narod S.A. (Breast Cancer Res. Treat. 2006)
    471. Diet, lifestyle and BRCA-related breast cancer risk among French-Canadians. (PubMed id 16541324)1, 4 Nkondjock A....Ghadirian P. (Breast Cancer Res. Treat. 2006)
    472. Mutation analysis of BRCA1 and BRCA2 from 793 Korean patients with sporadic breast cancer. (PubMed id 17100994)1, 4 Han S.H....Chung W.S. (Clin. Genet. 2006)
    473. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    474. Hormone replacement therapy and the risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers. (PubMed id 16137751)1, 4 Kotsopoulos J....Narod S.A. (Gynecol. Oncol. 2006)
    475. Low prevalence of BRCA1 exon rearrangements in familial and young sporadic breast cancer patients. (PubMed id 16724249)1, 4 Ellis D....Abbs S.J. (Fam. Cancer 2006)
    476. Screening mammography and risk of breast cancer in BRCA1 and BRCA2 mutation carriers: a case-control study. (PubMed id 16648044)1, 4 Narod S.A....Sun P. (Lancet Oncol. 2006)
    477. Childhood cancer in families with and without BRCA1 or BRCA2 mutations ascertained at a high-risk breast cancer clinic. (PubMed id 16931905)1, 4 Brooks G.A....Domchek S.M. (amp 2006)
    478. Characterization of BRCA1 and BRCA2 mutations in a large United States sample. (PubMed id 16484695)1, 4 Chen S....Parmigiani G. (J. Clin. Oncol. 2006)
    479. Influence of the MDM2 single nucleotide polymorphism SNP309 on tumour development in BRCA1 mutation carriers. (PubMed id 16563154)1, 4 Copson E.R....Eccles D.M. (BMC Cancer 2006)
    480. BRCA1 and BRCA2 mutation carriers, oral contraceptive use, and breast cancer before age 50. (PubMed id 17021353)1, 4 Haile R.W....Whittemore A.S. (amp 2006)
    481. BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP. (PubMed id 16818604)1, 2 Yu X.... Chen J. (Genes Dev. 2006)
    482. Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma among women in Connecticut. (PubMed id 16738949)1, 4 Shen M....Rothman N. (Hum. Genet. 2006)
    483. Coffee consumption and breast cancer risk among BRCA1 and BRCA2 mutation carriers. (PubMed id 16032702)1, 4 Nkondjock A....Narod S.A. (Int. J. Cancer 2006)
    484. [Prevalence of Val158Met polymorphism in COMT gene on non-BRCA1/2 hereditary breast cancer]. (PubMed id 17217814)1, 4 Song C.G....Shao Z.M. (Zhonghua Wai Ke Za Zhi 2006)
    485. Late toxicity is not increased in BRCA1/BRCA2 mutation carriers undergoing breast radiotherapy in the United Kingdom. (PubMed id 17145824)1, 4 Shanley S....Eeles R. (Clin. Cancer Res. 2006)
    486. ACCA phosphopeptide recognition by the BRCT repeats of BRCA1. (PubMed id 16698035)1, 2 Ray H.... Venezia N.D. (J. Mol. Biol. 2006)
    487. Search for large genomic alterations of the BRCA1 gene in a Finnish population. (PubMed id 16271956)1, 4 Laurila E....Karhu R. (Cancer Genet. Cytogenet. 2005)
    488. Effect of pregnancy as a risk factor for breast cancer in BRCA1/BRCA2 mutation carriers. (PubMed id 15986445)1, 4 Cullinane C.A....Narod S.A. (Int. J. Cancer 2005)
    489. The Tyr978X BRCA1 mutation: occurrence in non-Jewish Iranians and haplotype in French-Canadian and non-Ashkenazi Jews. (PubMed id 15951957)1, 4 Quintana-Murci L....Friedman E. (Fam. Cancer 2005)
    490. Impact of teenage oral contraceptive use in a population-based series of early-onset breast cancer cases who have undergone BRCA mutation testing. (PubMed id 16118051)1, 4 JernstrAPm H....Olsson H. (Eur. J. Cancer 2005)
    491. Hereditary breast cancer growth rates and its impact on screening policy. (PubMed id 15978801)1, 4 Tilanus-Linthorst M.M....Brekelmans C.T. (Eur. J. Cancer 2005)
    492. Mutational analysis of the BRCA1 gene in 30 Czech ovarian cancer patients. (PubMed id 15876585)1, 4 Zikan M....Stribrna J. (J. Genet. 2005)
    493. Changes in body weight and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. (PubMed id 16168130)1, 4 Kotsopoulos J....Narod S.A. (Breast Cancer Res. 2005)
    494. Prevalence of BRCA mutations and founder effect in high-risk Hispanic families. (PubMed id 16030099)1, 4 Weitzel J.N....Neuhausen S. (amp 2005)
    495. High prevalence of two BRCA1 mutations, 4154delA and 5382insC, in Latvia. (PubMed id 15951956)1, 4 Tikhomirova L....Stengrevics A. (Fam. Cancer 2005)
    496. Contribution of BRCA1 and BRCA2 germ-line mutations to the incidence of breast cancer in young women: results from a prospective population-based study in France. (PubMed id 15887246)1, 4 Bonadona V....Lasset C. (amp 2005)
    497. Prevalence of five previously reported and recurrent BRCA1 genetic rearrangement mutations in 20,000 patients from hereditary breast/ovarian cancer families. (PubMed id 15846789)1, 4 Hendrickson B.C....Scholl T. (amp 2005)
    498. Placental cadherin and the basal epithelial phenotype of BRCA1-related breast cancer. (PubMed id 15930334)1, 4 Arnes J.B....Foulkes W.D. (Clin. Cancer Res. 2005)
    499. Familial breast cancer: characteristics and outcome of BRCA 1-2 positive and negative cases. (PubMed id 15996267)1, 4 Veronesi A....Boiocchi M. (BMC Cancer 2005)
    500. Patients with an unclassified genetic variant in the BRCA1 or BRCA2 genes show different clinical features from those with a mutation. (PubMed id 15800311)1, 4 GA^mez-GarcA-a E.B....van den Wijngaard A. (J. Clin. Oncol. 2005)
    501. Haplotype analysis of common variants in the BRCA1 gene and risk of sporadic breast cancer. (PubMed id 15743496)1, 4 Cox D.G....Hunter D.J. (Breast Cancer Res. 2005)
    502. A haplotype-based case-control study of BRCA1 and sporadic breast cancer risk. (PubMed id 16103107)1, 4 Freedman M.L....Haiman C.A. (Cancer Res. 2005)
    503. Prevalence and clinical correlations of BRCA1/BRCA2 unclassified variant carriers among unselected primary ovarian cancer cases - preliminary report. (PubMed id 15617999)1, 4 Majdak E.J....Devilee P. (Eur. J. Cancer 2005)
    504. Risk of breast cancer recurrence and contralateral breast cancer in relation to BRCA1 and BRCA2 mutation status following breast-conserving surgery and radiotherapy. (PubMed id 16140006)1, 4 Kirova Y.M....Fourquet A. (Eur. J. Cancer 2005)
    505. Age at menarche and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. (PubMed id 16049805)1, 4 Kotsopoulos J....Narod S.A. (amp 2005)
    506. Breast and ovarian cancer risks to carriers of the BRCA1 5382insC and 185delAG and BRCA2 6174delT mutations: a combined analysis of 22 population based studies. (PubMed id 15994883)1, 4 Antoniou A.C....Easton D.F. (J. Med. Genet. 2005)
    507. Incidence of BRCA1 and BRCA2 mutations in young Korean breast cancer patients. (PubMed id 15117986)1, 4 Choi D.H....Haffty B.G. (J. Clin. Oncol. 2004)
    508. Prevalence of BRCA1 mutation carriers among U.S. non-Hispanic Whites. (PubMed id 15598764)1, 4 Whittemore A.S....West D.W. (amp 2004)
    509. Predictors of cognitive appraisals following genetic testing for BRCA1 and BRCA2 mutations. (PubMed id 15559734)1, 4 Halbert C.H....Lerman C. (J Behav Med 2004)
    510. Awareness of breast cancer genetics and interest in predictive genetic testing: a survey of a southern Italian population. (PubMed id 15280188)1, 4 Bruno M....Paradiso A. (Ann. Oncol. 2004)
    511. High-throughput association testing on DNA pools to identify genetic variants that confer susceptibility to acute myeloid leukemia. (PubMed id 15159312)1, 4 Rollinson S....Morgan G.J. (amp 2004)
    512. Cytoplasmic mislocalization of BRCA1 caused by cancer-associated mutations in the BRCT domain. (PubMed id 14729053)1, 4 Rodriguez J.A....Henderson B.R. (Exp. Cell Res. 2004)
    513. Relation of contraceptive and reproductive history to ovarian cancer risk in carriers and noncarriers of BRCA1 gene mutations. (PubMed id 15383404)1, 4 McGuire V....Whittemore A.S. (Am. J. Epidemiol. 2004)
    514. Frequency of the ATM IVS10-6T--&gt;G variant in Australian multiple-case breast cancer families. (PubMed id 15217508)1, 4 Lindeman G.J....Kirk J. (Breast Cancer Res. 2004)
    515. The 1100delAT BRCA1 and the 8765delAG BRCA2 mutations: occurrence in high-risk non-Ashkenazi Jews and haplotype comparison of Jewish and non-Jewish carriers. (PubMed id 15131400)1, 4 Gal I....Friedman E. (Fam. Cancer 2004)
    516. Loss of heterozygosity in normal breast epithelial tissue and benign breast lesions in BRCA1/2 carriers with breast cancer. (PubMed id 15104281)1, 4 Cavalli L.R....Haddad B.R. (Cancer Genet. Cytogenet. 2004)
    517. Impact of BRCA1/BRCA2 counseling and testing on newly diagnosed breast cancer patients. (PubMed id 15067026)1, 4 Schwartz M.D....Isaacs C. (J. Clin. Oncol. 2004)
    518. Clinical features of familial ovarian cancer lacking mutations in BRCA1 or BRCA2. (PubMed id 15053073)1, 4 Menkiszak J....LubiA8ski J. (Eur. J. Gynaecol. Oncol. 2004)
    519. BRCA1 and BRCA2 germline mutation spectrum and frequencies in Belgian breast/ovarian cancer families. (PubMed id 15026808)1, 2 Claes K.... Messiaen L. (Br. J. Cancer 2004)
    520. Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response. (PubMed id 15456891)1, 2 Zhang X....Legerski R.J. (Mol. Cell. Biol. 2004)
    521. Impact of BRCA1/2 testing and disclosure of a positive test result on women affected and unaffected with breast or ovarian cancer. (PubMed id 14735581)1, 4 van Roosmalen M.S....van Daal W.A. (Am. J. Med. Genet. A 2004)
    522. Cancer genetics knowledge and beliefs and receipt of results in Ashkenazi Jewish individuals receiving counseling for BRCA1/2 mutations. (PubMed id 15284715)1, 4 Kelly K....Schwalb M. (Cancer Control 2004)
    523. Efficacy of risk-reducing salpingo-oophorectomy in women with BRCA-1 and BRCA-2 mutations. (PubMed id 14984481)1, 4 Olopade O.I. and Artioli G. (Breast J 2004)
    524. A gene-environment interaction between occupation and BRCA1/BRCA2 mutations in male breast cancer? (PubMed id 15519522)1, 4 Palli D....Ottini L. (Eur. J. Cancer 2004)
    525. The presence of hereditary BRCA1 gene mutations in women with familial breast or ovarian cancer and the frequency of occurrence of these tumours in their relatives. (PubMed id 15285306)1, 4 Skasko E....PieA8kowski T. (Eur. J. Gynaecol. Oncol. 2004)
    526. Non-uptake of predictive genetic testing for BRCA1/2 among relatives of known carriers: attributes, cancer worry, and barriers to testing in a multicenter clinical cohort. (PubMed id 15140371)1, 4 Foster C....Watson M. (Genet. Test. 2004)
    527. Human claspin works with BRCA1 to both positively and negatively regulate cell proliferation. (PubMed id 15096610)1, 2 Lin S.-Y.... Elledge S.J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    528. Surveillance of BRCA1 and BRCA2 mutation carriers with magnetic resonance imaging, ultrasound, mammography, and clinical breast examination. (PubMed id 15367553)1, 4 Warner E....Narod S.A. (JAMA 2004)
    529. Accommodating risk: responses to BRCA1/2 genetic testing of women who have had cancer. (PubMed id 15144764)1, 4 Hallowell N....Watson M. (amp 2004)
    530. Randomised trial of a decision aid and its timing for women being tested for a BRCA1/2 mutation. (PubMed id 14735173)1, 4 van Roosmalen M.S....van Daal W.A. (Br. J. Cancer 2004)
    531. BRCA1 and sex ratio. (PubMed id 15114373)1, 4 Struewing J.P....Greene M.H. (Eur. J. Hum. Genet. 2004)
    532. Predictors of participation in psychosocial telephone counseling following genetic testing for BRCA1 and BRCA2 mutations. (PubMed id 15159322)1, 4 Halbert C.H....Bellamy S. (amp 2004)
    533. Association of NQO1 polymorphism with spontaneous breast cancer in two independent populations. (PubMed id 15138483)1, 4 Menzel H.J....Kraft H.G. (Br. J. Cancer 2004)
    534. Estrogen receptor status in BRCA1- and BRCA2-related breast cancer: the influence of age, grade, and histological type. (PubMed id 15041722)1, 4 Foulkes W.D....Narod S.A. (Clin. Cancer Res. 2004)
    535. An audit of screening for familial breast cancer before 50 years in the South Thames Region - have we got it right? (PubMed id 15131403)1, 4 Murday V....Hodgson S. (Fam. Cancer 2004)
    536. Survival and recurrence after breast cancer in BRCA1/2 mutation carriers. (PubMed id 14761918)1, 4 El-Tamer M....Mansukhani M. (Ann. Surg. Oncol. 2004)
    537. Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer. (PubMed id 15133502)1, 2 Clapperton J.A.... Smerdon S.J. (Nat. Struct. Mol. Biol. 2004)
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    539. Analyses of p53 expression pattern and BRCA mutations in patients with double primary breast and ovarian cancer. (PubMed id 15086724)1, 4 Bruchim I....Kopolovic J. (Int. J. Gynecol. Cancer 2004)
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    545. BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition. (PubMed id 14990569)1, 2 Ouchi M.... Ouchi T. (J. Biol. Chem. 2004)
    546. ERBB2, TBX2, RPS6KB1, and MYC alterations in breast tissues of BRCA1 and BRCA2 mutation carriers. (PubMed id 15236312)1, 4 Adem C....Jenkins R.B. (amp 2004)
    547. Offspring gender ratio and the rate of recurrent spontaneous miscarriages in jewish women at high risk for breast/ovarian cancer. (PubMed id 15116316)1, 4 Gal I....Friedman E. (Am. J. Hum. Genet. 2004)
    548. Smoking and the risk of breast cancer among carriers of BRCA mutations. (PubMed id 15095307)1, 4 Ghadirian P....Narod S.A. (Int. J. Cancer 2004)
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    554. Improved survival in women with BRCA-associated ovarian carcinoma. (PubMed id 12712470)1, 4 Cass I....Karlan B.Y. (Cancer 2003)
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    563. P53 codon 72 polymorphism and BRCA 1 and 2 mutations in ovarian epithelial malignancies in black South Africans. (PubMed id 12911720)1, 4 Pegoraro R.J....Moodley J. (Int. J. Gynecol. Cancer 2003)
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    586. Cancer incidence in relatives of a population-based set of cases of early-onset breast cancer with a known BRCA1 and BRCA2 mutation status. (PubMed id 14580253)1, 4 Loman N....Olsson H. (Breast Cancer Res. 2003)
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    593. The BRCA2 372 HH genotype is associated with risk of breast cancer in Australian women under age 60 years. (PubMed id 11927503)1, 4 Spurdle A.B....Chenevix-Trench G. (amp 2002)
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    677. Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha. (PubMed id 12438214)1, 9 Liu Y....Hsu L.C. (Cancer Res. 2002)
    678. BRCA1 localization to the telomere and its loss from the telomere in response to DNA damage. (PubMed id 19797051)1, 9 Ballal R.D....Rosen E.M. (J. Biol. Chem. 2009)
    679. Tumor suppressor BRCA1 is expressed in prostate cancer and controls insulin-like growth factor I receptor (IGF-IR) gene transcription in an androgen receptor-dependent manner. (PubMed id 19223505)1, 9 Schayek H....Werner H. (Clin. Cancer Res. 2009)
    680. Loss of heterozygosity at the BRCA2 locus detected by multiplex ligation-dependent probe amplification is common in prostate cancers from men with a germline BRCA2 mutation. (PubMed id 18445692)1, 9 Willems A.J....Thorne H.J. (Clin. Cancer Res. 2008)
    681. Involvement of a specificity proteins-binding element in regulation of basal and estrogen-induced transcription activity of the BRCA1 gene. (PubMed id 18377656)1, 9 Hockings J.K....Romagnolo D.F. (Breast Cancer Res. 2008)
    682. Ubiquitination and proteasomal degradation of the BRCA1 tumor suppressor is regulated during cell cycle progression. (PubMed id 15166217)1, 9 Choudhury A.D....Baer R. (J. Biol. Chem. 2004)
    683. Large BRCA1 and BRCA2 genomic rearrangements in Danish high risk breast-ovarian cancer families. (PubMed id 18546071)1, 9 Hansen T.v....Nielsen F.C. (Breast Cancer Res. Treat. 2009)
    684. Yeast screens identify the RNA polymerase II CTD and SPT5 as relevant targets of BRCA1 interaction. (PubMed id 18197258)1, 9 Bennett C.B....Marks J.R. (PLoS ONE 2008)
    685. The interaction of PP1 with BRCA1 and analysis of their expression in breast tumors. (PubMed id 17511879)1, 9 Winter S.L....Andrulis I.L. (BMC Cancer 2007)
    686. Novel consensus DNA-binding sequence for BRCA1 protein complexes. (PubMed id 14502648)1, 9 Cable P.L....Afshari C.A. (Mol. Carcinog. 2003)
    687. Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies. (PubMed id 11278964)1, 9 Gatei M....Khanna K.K. (J. Biol. Chem. 2001)
    688. Customized treatment in non-small-cell lung cancer based on EGFR mutations and BRCA1 mRNA expression. (PubMed id 19415121)1, 9 Rosell R....Taron M. (PLoS ONE 2009)
    689. BRCA1 is regulated by Chk2 in response to spindle damage. (PubMed id 18804494)1, 9 Chabalier-Taste C....Larminat F. (Biochim. Biophys. Acta 2008)
    690. BRCA1 promoter methylation in peripheral blood DNA of mutation negative familial breast cancer patients with a BRCA1 tumour phenotype. (PubMed id 18269736)1, 9 Snell C....Dobrovic A. (Breast Cancer Res. 2008)
    691. NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway. (PubMed id 19001859)1, 9 Wilson K.A. and Stern D.F. (Cell Cycle 2008)
    692. Growth factor signaling pathways modulate BRCA1 repression of estrogen receptor-alpha activity. (PubMed id 17505062)1, 9 Ma Y....Rosen E.M. (Mol. Endocrinol. 2007)
    693. BRCA1 DNA-binding activity is stimulated by BARD1. (PubMed id 16489000)1, 9 Simons A.M....Parvin J.D. (Cancer Res. 2006)
    694. Intronic alterations in BRCA1 and BRCA2: effect on mRNA splicing fidelity and expression. (PubMed id 16619214)1, 9 Chen X....Godwin A.K. (Hum. Mutat. 2006)
    695. BRCA1 interaction with human papillomavirus oncoproteins. (PubMed id 15983032)1, 9 Zhang Y....Rosen E.M. (J. Biol. Chem. 2005)
    696. Germline BRCA1 promoter deletions in UK and Australian familial breast cancer patients: Identification of a novel deletion consistent with BRCA1:psiBRCA1 recombination. (PubMed id 11933198)1, 9 Brown M.A....Solomon E. (Hum. Mutat. 2002)
    697. Direct interaction between BRCA1 and the estrogen receptor regulates vascular endothelial growth factor (VEGF) transcription and secretion in breast cancer cells. (PubMed id 12400015)1, 9 Kawai H....Avraham H.K. (Oncogene 2002)
    698. Expression of BRCA1 and BRCA2 in different tumor cell lines with various growth status. (PubMed id 11983207)1, 9 Vissac C....Bernard-Gallon D.J. ( international journal of clinical chemistry 2002)
    699. Role of direct interaction in BRCA1 inhibition of estrogen receptor activity. (PubMed id 11244506)1, 9 Fan S....Rosen E.M. (Oncogene 2001)
    700. Altered expression of BRCA1, BRCA2, and a newly identified BRCA2 exon 12 deletion variant in malignant human ovarian, prostate, and breast cancer cell lines. (PubMed id 10972993)1, 9 Rauh-Adelmann C....Ho S.M. (Mol. Carcinog. 2000)
    701. Mutations and alternative splicing of the BRCA1 gene in UK breast/ovarian cancer families. (PubMed id 9115959)1, 9 Xu C.F....Solomon E. (amp 1997)
    702. BRCA1 protein and nucleolin colocalize in breast carcinoma tissue and cancer cell lines. (PubMed id 20075200)1, 9 Tulchin N....Monteiro A.N. (Am. J. Pathol. 2010)
    703. The central region of BRCA1 binds preferentially to supercoiled DNA. (PubMed id 19492866)1, 9 BrA!zda V....Arrowsmith C.H. (amp 2009)
    704. PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2. (PubMed id 19584259)1, 9 Zhang F....Andreassen P.R. (Mol. Cancer Res. 2009)
    705. Immunolocalization of BRCA1 protein in tumor breast tissue: prescreening of BRCA1 mutation in Tunisian patients with hereditary breast cancer? (PubMed id 17921118)1, 9 Troudi W....Ben Ammar Elgaaied A. (Eur J Histochem 2007)
    706. Association of BRCA1 with the inactive X chromosome and XIST RNA. (PubMed id 15065664)1, 9 Ganesan S....Livingston D.M. (Philos. Trans. R. Soc. Lond., B, Biol. Sci. 2004)
    707. Role of BRCA1 in heat shock response. (PubMed id 12527903)1, 9 Xian Ma Y....Rosen E.M. (Oncogene 2003)
    708. Bovine BRCA1 shows classic responses to genotoxic stress but low in vitro transcriptional activation activity. (PubMed id 12955082)1, 9 Krum S.A....Lane T.F. (Oncogene 2003)
    709. BRCA1 regulates GADD45 through its interactions with the OCT-1 and CAAT motifs. (PubMed id 11777930)1, 9 Fan W....Zhan Q. (J. Biol. Chem. 2002)
    710. BRCA1-induced apoptosis involves inactivation of ERK1/2 activities. (PubMed id 12082091)1, 9 Yan Y....Cowan K.H. (J. Biol. Chem. 2002)
    711. BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases. (PubMed id 9244350)1, 9 Wang H....Rao V.N. (Oncogene 1997)
    712. Methylation not a frequent &quot;second hit&quot; in tumors with germline BRCA mutations. (PubMed id 19340607)1, 9 Dworkin A.M....Toland A.E. (Fam. Cancer 2009)
    713. Cisplatin-damaged BRCA1 exhibits altered thermostability and transcriptional transactivation. (PubMed id 19270496)1, 9 Ratanaphan A....Prasertsan P. (amp 2009)
    714. Molecular and in silico analysis of BRCA1 and BRCA2 variants. (PubMed id 18694767)1, 9 Tommasi S....Paradiso A. (Mutat. Res. 2008)
    715. Twenty-three novel BRCA1 and BRCA2 sequence alterations in breast and/or ovarian cancer families of Eastern Spain. (PubMed id 18060494)1, 9 Esteban CardeA+osa E....MartA-nez de DueA+as E. (Breast Cancer Res. Treat. 2008)
    716. Incidence of BRCA1 and BRCA2 mutations in 54 Chilean families with breast/ovarian cancer, genotype-phenotype correlations. (PubMed id 16261400)1, 9 Gallardo M....Carvallo P. (Breast Cancer Res. Treat. 2006)
    717. BRCA1 and BRCA2 germline mutational spectrum and evidence for genetic anticipation in Portuguese breast/ovarian cancer families. (PubMed id 16826315)1, 9 Peixoto A....Teixeira M.R. (Fam. Cancer 2006)
    718. Functional and physical interactions between BRCA1 and p53 in transcriptional regulation of the IGF-IR gene. (PubMed id 14710355)1, 9 Abramovitch S. and Werner H. (Horm. Metab. Res. 2003)
    719. siRNA depletion of BRCA1, but not BRCA2, causes increased genome instability in Fanconi anemia cells. (PubMed id 12967657)1, 9 Bruun D....Moses R. (DNA Repair (Amst.) 2003)
    720. BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis. (PubMed id 14559807)1, 9 Quinn J.E....Harkin D.P. (Cancer Res. 2003)
    721. Correlation between BRCA1 expression and apoptosis-related biological parameters in sporadic breast carcinomas. (PubMed id 12552965)1, 9 Yang Q....Kakudo K. (Anticancer Res. 2002)
    722. The p53 mutational spectrum associated with BRCA1 mutant ovarian cancer. (PubMed id 11309330)4, 9 Buller R.E....Kirby P.A. (Clin. Cancer Res. 2001)
    723. Cell cycle-dependent colocalization of BARD1 and BRCA1 proteins in discrete nuclear domains. (PubMed id 9342365)1, 9 Jin Y....Baer R. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    724. Targeting the FANCJ-BRCA1 interaction promotes a switch from recombination to poleta-dependent bypass. (PubMed id 20173781)1, 9 Xie J....Cantor S.B. (Oncogene 2010)
    725. BRCA1 promoter methylation associated with poor survival in Chinese patients with sporadic breast cancer. (PubMed id 19522853)1, 9 Chen Y....Deng D. (Cancer Sci. 2009)
    726. A novel mechanism whereby BRCA1/1a/1b fine tunes the dynamic complex interplay between SUMO-dependent/independent activities of Ubc9 on E2-induced ERalpha activation/repression and degradation in breast cancer cells. (PubMed id 19287951)1, 9 Xu J....Rao V.N. (Int. J. Oncol. 2009)
    727. Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair. (PubMed id 18171670)1, 9 Chen L....Wu X. (J. Biol. Chem. 2008)
    728. Nuclear export of BRCA1 occurs during early S phase and is calcium-dependent. (PubMed id 18296025)1, 9 Glover-Collins K. and Thompson M.E. (Cell. Signal. 2008)
    729. Skewed X chromosome inactivation and breast and ovarian cancer status: evidence for X-linked modifiers of BRCA1. (PubMed id 18957670)1, 9 Lose F.... . (J. Natl. Cancer Inst. 2008)
    730. The CHEK2 1100delC mutation is not present in Korean patients with breast cancer cases tested for BRCA1 and BRCA2 mutation. (PubMed id 18175216)1, 9 Choi D.H....Haffty B.G. (Breast Cancer Res. Treat. 2008)
    731. Concerted transcriptional regulation by BRCA1 and COBRA1 in breast cancer cells. (PubMed id 18071589)1, 9 Aiyar S.E....Li R. (Int. J. Biol. Sci. 2007)
    732. Brca1 heterozygous mice have shortened life span and are prone to ovarian tumorigenesis with haploinsufficiency upon ionizing irradiation. (PubMed id 17420720)1, 9 Jeng Y.M....Lee W.H. (Oncogene 2007)
    733. Prognostic value of BRCA1 mutations in familial breast cancer patients affected by a second primary cancer. (PubMed id 17520345)1, 9 Elsakov P....Ostapenko V. (Fam. Cancer 2007)
    734. BRCA1 gene expression in breast cancer: a correlative study between real-time RT-PCR and immunohistochemistry. (PubMed id 15872055)1, 9 Al-Mulla F....Anim J.T. (J. Histochem. Cytochem. 2005)
    735. Truncating BRCA1 mutations are uncommon in a cohort of hereditary prostate cancer families with evidence of linkage to 17q markers. (PubMed id 15447980)1, 9 Zuhlke K.A....Cooney K.A. (Clin. Cancer Res. 2004)
    736. Nuclear-cytoplasmic shuttling of BARD1 contributes to its proapoptotic activity and is regulated by dimerization with BRCA1. (PubMed id 14647430)1, 9 Rodriguez J.A....Henderson B.R. (Oncogene 2004)
    737. Novel germline BRCA1 and BRCA2 mutations in breast and breast/ovarian cancer families from the Czech Republic. (PubMed id 11748848)1, 9 Machackova E....Foretova L. (Hum. Mutat. 2001)
    738. Mapping the functional domains of BRCA1. Interaction of the ring finger domains of BRCA1 and BARD1. (PubMed id 10026184)1, 9 Meza J.E.... Klevit R.E. (J. Biol. Chem. 1999)
    739. The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter. (PubMed id 9926942)1, 9 Chai Y.L....Rao V.N. (Oncogene 1999)
    740. Distinct somatic genetic changes associated with tumor progression in carriers of BRCA1 and BRCA2 germ-line mutations. (PubMed id 9102202)4, 9 Tirkkonen M....Kallioniemi O.P. (Cancer Res. 1997)
    741. Immunohistochemical expression of BRCA1 and lethal prostate cancer. (PubMed id 20388772)1, 9 Fiorentino M....Mucci L. (Cancer Res. 2010)
    742. Selenium supplementation reduced oxidative DNA damage in adnexectomized BRCA1 mutations carriers. (PubMed id 19843683)1, 9 Dziaman T....Olinski R. (amp 2009)
    743. [The prevalence of BRCA1 mutations among families at high-risk of breast and ovarian cancer in province of Malopolska between 2004-2009]. (PubMed id 20514903)1, 9 Blecharz P....UrbaA8ski K. (Prz. Lek. 2009)
    744. The contribution of BRCA1 and BRCA2 to ovarian cancer. (PubMed id 19383375)1, 9 Ramus S.J. and Gayther S.A. (Mol Oncol 2009)
    745. Analysis of large deletions in BRCA1, BRCA2 and PALB2 genes in Finnish breast and ovarian cancer families. (PubMed id 18501021)1, 9 PylkAos K....Winqvist R. (BMC Cancer 2008)
    746. AKT1 inhibits homologous recombination by inducing cytoplasmic retention of BRCA1 and RAD51. (PubMed id 19010915)1, 9 Plo I....Lopez B.S. (Cancer Res. 2008)
    747. Promotion of BRCA1-associated triple-negative breast cancer by ovarian hormones. (PubMed id 18197009)1, 9 Lee E.Y. (amp 2008)
    748. The spectrum and incidence of BRCA1 pathogenic mutations in Slovak breast/ovarian cancer families. (PubMed id 17319787)1, 9 Konecny M....Kausitz J. (Neoplasma 2007)
    749. Germline BRCA1 mutation and survival analysis in familial breast cancer patients in Kerala; South India. (PubMed id 17987791)1, 9 Vinodkumar B....Ankathil R. (amp 2007)
    750. A review of histopathological subtypes of ovarian cancer in BRCA-related French Canadian cancer families. (PubMed id 17636423)1, 9 Tonin P.N....Provencher D.M. (Fam. Cancer 2007)
    751. BRCA1 mutation and young age predict fast breast cancer growth in the Dutch, United Kingdom, and Canadian magnetic resonance imaging screening trials. (PubMed id 18094417)1, 9 Tilanus-Linthorst M.M....Gilbert F.J. (Clin. Cancer Res. 2007)
    752. The breast cancer susceptibility gene BRCA1 regulates progesterone receptor signaling in mammary epithelial cells. (PubMed id 16109739)1, 9 Ma Y....Rosen E.M. (Mol. Endocrinol. 2006)
    753. An estrogen receptor-alpha/p300 complex activates the BRCA-1 promoter at an AP-1 site that binds Jun/Fos transcription factors: repressive effects of p53 on BRCA-1 transcription. (PubMed id 16229810)1, 9 Jeffy B.D....Romagnolo D.F. (Neoplasia 2005)
    754. 53BP1 is a positive regulator of the BRCA1 promoter. (PubMed id 15970701)1, 9 Rauch T....Xu X. (Cell Cycle 2005)
    755. In vitro platination of human breast cancer suppressor gene1 (BRCA1) by the anticancer drug carboplatin. (PubMed id 16099593)1, 9 Ratanaphan A....Mahasawat P. (Biochim. Biophys. Acta 2005)
    756. Cyclin D1 antagonizes BRCA1 repression of estrogen receptor alpha activity. (PubMed id 16061635)1, 9 Wang C....Pestell R.G. (Cancer Res. 2005)
    757. BARD1 regulates BRCA1 apoptotic function by a mechanism involving nuclear retention. (PubMed id 15265711)1, 9 Fabbro M....Henderson B.R. (Exp. Cell Res. 2004)
    758. Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpoint. (PubMed id 12810625)1, 9 Yamane K....Kinsella T.J. (Cancer Res. 2003)
    759. BRCA1 augments transcription by the NF-kappaB transcription factor by binding to the Rel domain of the p65/RelA subunit. (PubMed id 12700228)1, 9 Benezra M....Licht J.D. (J. Biol. Chem. 2003)
    760. Cancer risk estimates for BRCA1 mutation carriers identified in a risk evaluation program. (PubMed id 12237282)1, 9 Brose M.S....Weber B.L. (J. Natl. Cancer Inst. 2002)
    761. CGH-targeted linkage analysis reveals a possible BRCA1 modifier locus on chromosome 5q. (PubMed id 12019214)1, 9 Nathanson K.L....Weber B.L. (Hum. Mol. Genet. 2002)
    762. Conservation of function and primary structure in the BRCA1-associated RING domain (BARD1) protein. (PubMed id 9798686)1, 9 Ayi T.C....Baer R. (Oncogene 1998)
    763. Somatic mutations in the BRCA1 gene in sporadic ovarian tumours. (PubMed id 7795652)1, 9 Merajver S.D....Frank T.S. (Nat. Genet. 1995)
    764. Negative feedback loop of BRCA1-BARD1 ubiquitin ligase on estrogen receptor alpha stability and activity antagonized by cancer-associated isoform of BARD1. (PubMed id 20060929)1, 9 Dizin E. and Irminger-Finger I. (amp 2010)
    765. Use of DNA-damaging agents and RNA pooling to assess expression profiles associated with BRCA1 and BRCA2 mutation status in familial breast cancer patients. (PubMed id 20174566)1, 9 Walker L.C....Spurdle A.B. (PLoS Genet. 2010)
    766. Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. (PubMed id 19648928)1, 9 Lim E....Lindeman G.J. (Nat. Med. 2009)
    767. Association of loss of BRCA1 expression with centrosome aberration in human breast cancer. (PubMed id 18813953)1, 9 Shimomura A....Noguchi S. (J. Cancer Res. Clin. Oncol. 2009)
    768. Age at onset of bilateral breast cancer, the presence of hereditary BRCA1, BRCA2, CHEK2 gene mutations and positive family history of cancer. (PubMed id 19372713)1, 9 Skasko E....PieA8kowski T. (Onkologie 2009)
    769. Aneuploidy is associated with TP53 expression but not with BRCA1 or TERT expression in sporadic colorectal cancer. (PubMed id 20032382)1, 9 SchjA...De Angelis P.M. (Anticancer Res. 2009)
    770. Tamoxifen and the risk of ovarian cancer in BRCA1 mutation carriers. (PubMed id 19577280)4, 9 Vicus D....Narod S.A. (Gynecol. Oncol. 2009)
    771. Clinical characteristics of laryngeal cancer in BRCA-1 mutation carriers. (PubMed id 19596949)1, 9 Jaworowska E....LubiA8ski J. (Anticancer Res. 2009)
    772. Deletions of BRCA1/2 and p53 R248W gain-of-function mutation suggest impaired homologous recombination repair in fragile histidine triad-negative sebaceous gland carcinomas. (PubMed id 18717684)1, 9 Becker K....Ballhausen W.G. (Br. J. Dermatol. 2008)
    773. BRCA1/BRCA2 rearrangements and CHEK2 common mutations are infrequent in Italian male breast cancer cases. (PubMed id 17661168)1, 9 Falchetti M....Ottini L. (Breast Cancer Res. Treat. 2008)
    774. Tumor BRCA1, RRM1 and RRM2 mRNA expression levels and clinical response to first-line gemcitabine plus docetaxel in non-small-cell lung cancer patients. (PubMed id 19002265)1, 9 Boukovinas I....Souglakos J. (PLoS ONE 2008)
    775. BRCA1 overexpression sensitizes cancer cells to lovastatin via regulation of cyclin D1-CDK4-p21WAF1/CIP1 pathway: analyses using a breast cancer cell line and tumoral xenograft model. (PubMed id 18695886)1, 9 Yu X....Tang Y. (Int. J. Oncol. 2008)
    776. Risks of cancer due to a single BRCA1 mutation in an extended Utah kindred. (PubMed id 17051349)1, 9 Vogl F.D....Goldgar D.E. (Fam. Cancer 2007)
    777. Promoter hypermethylation of TMS1, BRCA1, ERalpha and PRB in serum and tumor DNA of invasive ductal breast carcinoma patients. (PubMed id 17599361)1, 9 Mirza S....Ralhan R. (Life Sci. 2007)
    778. A role of estrogen/ERalpha signaling in BRCA1-associated tissue-specific tumor formation. (PubMed id 17496925)1, 9 Li W....Deng C.X. (Oncogene 2007)
    779. Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer. (PubMed id 17626182)1, 9 Liu X....Jonkers J. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    780. Compromised Fanconi anemia response due to BRCA1 deficiency in cisplatin-sensitive head and neck cancer cell lines. (PubMed id 17321670)1, 9 Burkitt K. and Ljungman M. (Cancer Lett. 2007)
    781. Elevated insulin-like growth factor-I receptor (IGF-IR) levels in primary breast tumors associated with BRCA1 mutations. (PubMed id 17766039)1, 9 Maor S....Werner H. (Cancer Lett. 2007)
    782. Genetic analysis of BRCA1 ubiquitin ligase activity and its relationship to breast cancer susceptibility. (PubMed id 16403807)1, 9 Morris J.R....Solomon E. (Hum. Mol. Genet. 2006)
    783. Basal repression of BRCA1 by multiple E2Fs and pocket proteins at adjacent E2F sites. (PubMed id 17106239)1, 9 Bindra R.S. and Glazer P.M. (amp 2006)
    784. Expression of DNA double-strand break repair proteins ATM and BRCA1 predicts survival in colorectal cancer. (PubMed id 16533773)1, 9 Grabsch H....Mueller W. (Clin. Cancer Res. 2006)
    785. Down-regulation of BRCA1-BARD1 ubiquitin ligase by CDK2. (PubMed id 15665273)1, 9 Hayami R....Ohta T. (Cancer Res. 2005)
    786. Novel somatic mutations in the BRCA1 gene in sporadic breast tumors. (PubMed id 15712267)1, 9 Janatova M....Pohlreich P. (Hum. Mutat. 2005)
    787. Down-regulation of BRCA1 in chronic pancreatitis and sporadic pancreatic adenocarcinoma. (PubMed id 15173085)1, 9 Beger C....Beger H.G. (Clin. Cancer Res. 2004)
    788. Nucleophosmin/B23 is a candidate substrate for the BRCA1-BARD1 ubiquitin ligase. (PubMed id 15184379)1, 9 Sato K....Ohta T. (J. Biol. Chem. 2004)
    789. Functional dissection of transcription factor ZBRK1 reveals zinc fingers with dual roles in DNA-binding and BRCA1-dependent transcriptional repression. (PubMed id 14660588)1, 9 Tan W....Boyer T.G. (J. Biol. Chem. 2004)
    790. Comparison of BRCT domains of BRCA1 and 53BP1: a biophysical analysis. (PubMed id 14978302)1, 9 Ekblad C.M....Itzhaki L.S. (Protein Sci. 2004)
    791. Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control. (PubMed id 12611903)1, 9 Lou Z.... Chen J. (J. Biol. Chem. 2003)
    792. Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein. (PubMed id 12431996)1, 9 Xia Y....Hunter T. (J. Biol. Chem. 2003)
    793. Mutation analysis of BrCA1, BrCA2, and p53 versus soluble HLA class I and class II in a case of familial endometriosis. (PubMed id 12568865)1, 9 Goumenou A.G....Koutsilieris M. (Fertil. Steril. 2003)
    794. Loss of BRCA1 expression in sporadic male breast carcinoma. (PubMed id 11859870)1, 9 Sun X....Badve S. (Breast Cancer Res. Treat. 2002)
    795. A low frequency of non-founder BRCA1 mutations in Ashkenazi Jewish breast-ovarian cancer families. (PubMed id 12402332)1, 9 Phelan C.M....Narod S.A. (Hum. Mutat. 2002)
    796. Analysis of BRCA1, TP53, and TSG101 germline mutations in German breast and/or ovarian cancer families. (PubMed id 12505256)1, 9 Balz V....Bojar H. (Cancer Genet. Cytogenet. 2002)
    797. Constitutive association of BRCA1 and c-Abl and its ATM-dependent disruption after irradiation. (PubMed id 12024016)1, 9 Foray N....Jeggo P. (Mol. Cell. Biol. 2002)
    798. Activation of the aromatic hydrocarbon receptor pathway is not sufficient for transcriptional repression of BRCA-1: requirements for metabolism of benzo[a]pyrene to 7r,8t-dihydroxy-9t,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene. (PubMed id 11782367)1, 9 Jeffy B.D....Romagnolo D.F. (Cancer Res. 2002)
    799. Expression profiles of BRCA1 splice variants in asynchronous and in G1/S synchronized tumor cell lines. (PubMed id 11162473)1, 9 Orban T.I. and Olah E. (Biochem. Biophys. Res. Commun. 2001)
    800. The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation. (PubMed id 11278247)1, 9 Hashizume R....Ohta T. (J. Biol. Chem. 2001)
    801. BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor. (PubMed id 11493692)1, 9 Zheng L....Boyer T.G. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    802. Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1. (PubMed id 11090615)1, 9 Zheng L....Lee H.W. (Mol. Cell 2000)
    803. Increase of androgen-induced cell death and androgen receptor transactivation by BRCA1 in prostate cancer cells. (PubMed id 11016951)1, 9 Yeh S....Chang C. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    804. BRCA1 inhibition of estrogen receptor signaling in transfected cells. (PubMed id 10334989)1, 9 Fan S....Rosen E.M. (Science 1999)
    805. Association of BRCA1 with Rad51 in mitotic and meiotic cells. (PubMed id 9008167)1, 9 Scully R....Livingston D.M. (Cell 1997)
    806. Hereditary breast and ovarian cancer due to mutations in BRCA1 and BRCA2. (PubMed id 20216074)1, 9 Petrucelli N....Feldman G.L. (Genet. Med. 2010)
    807. BRCA1 mutations in women with familial or early-onset breast cancer and BRCA2 mutations in familial cancer in Estonia. (PubMed id 20380699)1, 9 Tamboom K....Veidebaum T. (Hered Cancer Clin Pract 2010)
    808. Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks. (PubMed id 20016603)1, 9 Galanty Y....Jackson S.P. (Nature 2009)
    809. BRCA1 expression and molecular alterations in familial breast cancer. (PubMed id 19012246)1, 9 Mangia A....Paradiso A. (Histol. Histopathol. 2009)
    810. Promoter methylation patterns of ATM, ATR, BRCA1, BRCA2 and p53 as putative cancer risk modifiers in Jewish BRCA1/BRCA2 mutation carriers. (PubMed id 18642075)1, 9 Kontorovich T....Friedman E. (Breast Cancer Res. Treat. 2009)
    811. A role for BRCA1 in uterine leiomyosarcoma. (PubMed id 19843854)1, 9 Xing D....Orsulic S. (Cancer Res. 2009)
    812. Expression profile of BRCA1 and BRCA2 genes in premenopausal Mexican women with breast cancer: clinical and immunohistochemical correlates. (PubMed id 19012002)1, 9 Loredo-Pozos G....Ramos-MA!rquez M.E. (Med. Oncol. 2009)
    813. Resveratrol induces senescence-like growth inhibition of U-2 OS cells associated with the instability of telomeric DNA and upregulation of BRCA1. (PubMed id 19559722)1, 9 Rusin M....Butkiewicz D. (Mech. Ageing Dev. 2009)
    814. BRCA1 down-regulates cellular levels of reactive oxygen species. (PubMed id 19364506)1, 9 Saha T....Rosen E.M. (FEBS Lett. 2009)
    815. The DNA repair proteins BRCA1 and ERCC1 as predictive markers in sporadic ovarian cancer. (PubMed id 19035454)1, 9 Weberpals J....Dimitroulakos J. (Int. J. Cancer 2009)
    816. Distinct roles of BARD1 isoforms in mitosis: full-length BARD1 mediates Aurora B degradation, cancer-associated BARD1beta scaffolds Aurora B and BRCA2. (PubMed id 19176389)1, 9 Ryser S....Irminger-Finger I. (Cancer Res. 2009)
    817. Decreased BRCA1 confers tamoxifen resistance in breast cancer cells by altering estrogen receptor-coregulator interactions. (PubMed id 18997820)1, 9 Wen J....Shupnik M.A. (Oncogene 2009)
    818. Dynamic interactions between the promoter and terminator regions of the mammalian BRCA1 gene. (PubMed id 18375767)1, 9 Tan-Wong S.M....Brown M.A. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    819. Expression of BRCA1 protein in breast cancer and its prognostic significance. (PubMed id 18400253)1, 9 Rakha E.A....Ellis I.O. (Hum. Pathol. 2008)
    820. [Influence of mifepristone on DNA repair genes and cisplatin sensitivity in human ovarian cancer drug-resistance cells]. (PubMed id 18683754)1, 9 Liu G.Y....Qi J. (Zhonghua Fu Chan Ke Za Zhi 2008)
    821. [Evaluation of stomatognathic system in BRCA1 gene mutation carriers before and after prophylactic adnexectomy--part II: evaluation of stomatognathic system in BRCA1 gene mutation carriers after prophylactic adnexectomy]. (PubMed id 19374245)1, 9 ChruA9ciel-Nogalska M. (Ann Acad Med Stetin 2008)
    822. Re-engineering a split-GFP reassembly screen to examine RING-domain interactions between BARD1 and BRCA1 mutants observed in cancer patients. (PubMed id 18493658)1, 9 Sarkar M. and Magliery T.J. (Mol Biosyst 2008)
    823. BRCA1 mRNA expression levels predict for overall survival in ovarian cancer after chemotherapy. (PubMed id 18094425)1, 9 Quinn J.E....Harkin D.P. (Clin. Cancer Res. 2007)
    824. RAD51 up-regulation bypasses BRCA1 function and is a common feature of BRCA1-deficient breast tumors. (PubMed id 17942895)1, 9 Martin R.W....Bishop D.K. (Cancer Res. 2007)
    825. X inactive-specific transcript RNA coating and genetic instability of the X chromosome in BRCA1 breast tumors. (PubMed id 17545591)1, 9 Vincent-Salomon A....Heard E. (Cancer Res. 2007)
    826. Elevated levels of somatic mutation in a manifesting BRCA1 mutation carrier. (PubMed id 18158561)1, 9 Grant S.G....Latimer J.J. (Pathol. Oncol. Res. 2007)
    827. The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells. (PubMed id 17581638)1, 9 Peng M....Cantor S.B. (EMBO J. 2007)
    828. Regulation of the BRCA1 promoter in ovarian surface epithelial cells and ovarian carcinoma cells. (PubMed id 17434164)1, 9 Graves M.L....Roskelley C.D. (FEBS Lett. 2007)
    829. Medullary carcinoma of breast with a novel germline mutation 1123T &gt;G in exon 11 of BRCA1. (PubMed id 16945238)1, 9 Moattar T....Pervez S. (J Coll Physicians Surg Pak 2006)
    830. TP53 mutations in ovarian carcinomas from sporadic cases and carriers of two distinct BRCA1 founder mutations; relation to age at diagnosis and survival. (PubMed id 16229746)1, 9 Kringen P....Dorum A. (BMC Cancer 2005)
    831. Phosphorylated BRCA1 is predominantly located in the nucleus and mitochondria. (PubMed id 15591126)1, 9 Coene E.D....Vaux D.J. (Mol. Biol. Cell 2005)
    832. Modulation of aromatase expression by BRCA1: a possible link to tissue-specific tumor suppression. (PubMed id 16170371)1, 9 Hu Y....Li R. (Oncogene 2005)
    833. BRCA1 in hormonal carcinogenesis: basic and clinical research. (PubMed id 16172191)1, 9 Rosen E.M....Isaacs C. (Endocr. Relat. Cancer 2005)
    834. BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly. (PubMed id 16217032)1, 9 Lin S.Y....Elledge S.J. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    835. ATR and GADD45alpha mediate HIV-1 Vpr-induced apoptosis. (PubMed id 15650754)1, 9 Andersen J.L....Planelles V. (Cell Death Differ. 2005)
    836. BRCA1 gene expression in breast cancer in Kuwait: correlation with prognostic parameters. (PubMed id 15785095)1, 9 Amirrad M....Anim J.T. (Med Princ Pract 2005)
    837. BRCA1 and pancreatic cancer: pedigree findings and their causal relationships. (PubMed id 15796958)1, 9 Lynch H.T....Brand R.E. (Cancer Genet. Cytogenet. 2005)
    838. RNA analysis reveals splicing mutations and loss of expression defects in MLH1 and BRCA1. (PubMed id 15300854)1, 9 Sharp A.... Eccles D. (Hum. Mutat. 2004)
    839. BRCA1 induces antioxidant gene expression and resistance to oxidative stress. (PubMed id 15520196)1, 9 Bae I....Rosen E.M. (Cancer Res. 2004)
    840. Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair. (PubMed id 14701743)1, 9 Zhang J....Xia F. (Mol. Cell. Biol. 2004)
    841. Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling. (PubMed id 15125843)1, 9 Shiozaki E.N.... Shi Y. (Mol. Cell 2004)
    842. BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage. (PubMed id 15159397)1, 9 Fabbro M....Khanna K.K. (J. Biol. Chem. 2004)
    843. BRCA1 and p53: compensatory roles in DNA repair. (PubMed id 13679996)1, 9 Hartman A.R. and Ford J.M. (J. Mol. Med. 2003)
    844. A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein. (PubMed id 12773400)1, 9 Foray N....Jeggo P. (EMBO J. 2003)
    845. BRCA1 splice variants exhibit overlapping and distinct transcriptional transactivation activities. (PubMed id 12682913)1, 9 McEachern K.A....Arrick B.A. (J. Cell. Biochem. 2003)
    846. Control of biochemical reactions through supramolecular RING domain self-assembly. (PubMed id 12438698)1, 9 Kentsis A....Borden K.L. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    847. Transactivation of repair genes by BRCA1. (PubMed id 12496474)1, 9 El-Deiry W.S. (amp 2002)
    848. S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51. (PubMed id 12239151)1, 9 Taniguchi T.... D'Andrea A.D. (Blood 2002)
    849. Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure. (PubMed id 11877378)1, 9 Joo W.S....Pavletich N.P. (Genes Dev. 2002)
    850. The BRCA1 and BARD1 association with the RNA polymerase II holoenzyme. (PubMed id 12154023)1, 9 Chiba N. and Parvin J.D. (Cancer Res. 2002)
    851. Loss of heterozygosity of p53, BRCA1, VHL, and estrogen receptor genes in breast carcinoma: correlation with related protein products and morphologic features. (PubMed id 12490973)1, 9 Otis C.N....Merino M.J. (Int. J. Surg. Pathol. 2002)
    852. p300 Modulates the BRCA1 inhibition of estrogen receptor activity. (PubMed id 11782371)1, 9 Fan S....Rosen E.M. (Cancer Res. 2002)
    853. Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes. (PubMed id 10868478)1, 9 Meng Q....Fan S. (J. Mol. Med. 2000)
    854. Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells. (PubMed id 10542266)1, 9 Altiok S....Avraham H. (J. Biol. Chem. 1999)
    855. The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of transcriptional repression. (PubMed id 9738006)1, 9 Yu X....Baer R. (J. Biol. Chem. 1998)
    856. Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. (PubMed id 9267023)1, 9 Scully R....Livingston D.M. (Cell 1997)
    857. A comparison of BRCA1 nuclear localization with 14 DNA damage response proteins and domains: identification of specific differences between BRCA1 and 53BP1 at DNA damage-induced foci. (PubMed id 19766185)1, 9 Mok M.T. and Henderson B.R. (Cell. Signal. 2010)
    858. Concomitant loss of heterozygosity at the BRCA1 and FHIT genes as a prognostic factor in sporadic breast cancer. (PubMed id 20417865)1, 9 Silva Soares E.W....de Souza Fonseca Ribeiro E.M. (Cancer Genet. Cytogenet. 2010)
    859. 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers. (PubMed id 20453858)1, 9 Bouwman P....Jonkers J. (amp 2010)
    860. The prognostic value of BRCA1 mRNA expression levels following neoadjuvant chemotherapy in breast cancer. (PubMed id 20209131)1, 9 Margeli M....Rosell R. (PLoS ONE 2010)
    861. BRCA1 regulates acetylation and ubiquitination of estrogen receptor-alpha. (PubMed id 19887647)1, 9 Ma Y....Rosen E.M. (Mol. Endocrinol. 2010)
    862. DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response. (PubMed id 20338046)1, 9 Dejeux E....Tost J. (Mol. Cancer 2010)
    863. Characterization of BRCA1 and BRCA2 deleterious mutations and variants of unknown clinical significance in unilateral and bilateral breast cancer: the WECARE study. (PubMed id 20104584)1, 9 Borg A....Bernstein J.L. (Hum. Mutat. 2010)
    864. HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype. (PubMed id 20389018)1, 9 Gilbert P.M....Weaver V.M. (J. Clin. Invest. 2010)
    865. BRCA1/BARD1 E3 ubiquitin ligase can modify histones H2A and H2B in the nucleosome particle. (PubMed id 19916563)1, 9 Thakar A....Zlatanova J. (amp 2010)
    866. Downregulation of EZH2 decreases growth of estrogen receptor-negative invasive breast carcinoma and requires BRCA1. (PubMed id 19079346)1, 9 Gonzalez M.E....Kleer C.G. (Oncogene 2009)
    867. Hereditary ovarian carcinoma: heterogeneity, molecular genetics, pathology, and management. (PubMed id 19383374)1, 9 Lynch H.T....Godwin A.K. (Mol Oncol 2009)
    868. Role of BRCA1, HSD17B1 and HSD17B2 methylation in breast cancer tissue. (PubMed id 19729830)1, 9 Bhavani V....Hasan Q. (Cancer Biomark 2009)
    869. Prognostic relevance of promoter hypermethylation of multiple genes in breast cancer patients. (PubMed id 19940364)1, 9 Sharma G....Ralhan R. (Cell. Oncol. 2009)
    870. A novel BRCA1 mutation in a Spanish patient with ovarian cancer. (PubMed id 18278587)1, 9 Salgado J....GarcA-a-Foncillas J. (Breast Cancer Res. Treat. 2009)
    871. PALB2 links BRCA1 and BRCA2 in the DNA-damage response. (PubMed id 19268590)1, 9 Zhang F....Yu X. (Curr. Biol. 2009)
    872. Utility of DNA repair protein foci for the detection of putative BRCA1 pathway defects in breast cancer biopsies. (PubMed id 19671671)1, 9 Willers H....Powell S.N. (Mol. Cancer Res. 2009)
    873. BRCA1 promoter methylation is associated with increased mortality among women with breast cancer. (PubMed id 18521744)1, 9 Xu X....Chen J. (Breast Cancer Res. Treat. 2009)
    874. Ubiquitination and downregulation of BRCA1 by ubiquitin-conjugating enzyme E2T overexpression in human breast cancer cells. (PubMed id 19887602)1, 9 Ueki T....Katagiri T. (Cancer Res. 2009)
    875. Premature senescence is a major response to DNA cross-linking agents in BRCA1-defective cells: implication for tailored treatments of BRCA1 mutation carriers. (PubMed id 19372557)1, 9 Santarosa M....Maestro R. (Mol. Cancer Ther. 2009)
    876. Association of hormone receptor status with grading, age of onset, and tumor size in BRCA1-associated breast cancer. (PubMed id 19381686)1, 9 Graeser M....Schmutzler R.K. (Virchows Arch. 2009)
    877. Prolactin blocks nuclear translocation of VDR by regulating its interaction with BRCA1 in osteosarcoma cells. (PubMed id 19074549)1, 9 Deng C....Walker A.M. (Mol. Endocrinol. 2009)
    878. A novel deletion of BRCA1 gene that eliminates the ATG initiation codon without affecting the promoter region. (PubMed id 19393826)1, 9 Marino M....Calandra S. ( international journal of clinical chemistry 2009)
    879. BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activity. (PubMed id 19117993)1, 9 Nishikawa H.... Ohta T. (Cancer Res. 2009)
    880. Inactivation of the Nijmegen breakage syndrome gene leads to excess centrosome duplication via the ATR/BRCA1 pathway. (PubMed id 19244116)1, 9 Shimada M....Komatsu K. (Cancer Res. 2009)
    881. XPG mRNA expression levels modulate prognosis in resected non-small-cell lung cancer in conjunction with BRCA1 and ERCC1 expression. (PubMed id 19289372)1, 9 Bartolucci R....Rosell R. (Clin Lung Cancer 2009)
    882. Human SNF5/INI1, a component of the human SWI/SNF chromatin remodeling complex, promotes nucleotide excision repair by influencing ATM recruitment and downstream H2AX phosphorylation. (PubMed id 19805520)1, 9 Ray A....Wani A.A. (Mol. Cell. Biol. 2009)
    883. Promoter hypermethylation of BRCA1 correlates with absence of expression in hereditary breast cancer tumors. (PubMed id 18567944)1, 9 Tapia T....Carvallo P. (Epigenetics 2008)
    884. BRCA1-mediated ubiquitination inhibits topoisomerase II alpha activity in response to oxidative stress. (PubMed id 18162055)1, 9 Shinagawa H....Yoshida K. (amp 2008)
    885. Methylation is less abundant in BRCA1-associated compared with sporadic breast cancer. (PubMed id 18647968)1, 9 Suijkerbuijk K.P....van Diest P.J. (Ann. Oncol. 2008)
    886. On the dynamics of breast tumor development in women carrying germline BRCA1 and BRCA2 mutations. (PubMed id 18098285)1, 9 Simon R. and Zhang X. (Int. J. Cancer 2008)
    887. BRCA1 5083del19 mutant allele selectively up-regulates periostin expression in vitro and in vivo. (PubMed id 18980973)1, 9 Quaresima B....Costanzo F. (Clin. Cancer Res. 2008)
    888. Gamma-irradiation-induced DNA damage checkpoint activation involves feedback regulation between extracellular signal-regulated kinase 1/2 and BRCA1. (PubMed id 18593910)1, 9 Yan Y....Cowan K.H. (Cancer Res. 2008)
    889. Occult fallopian tube cancer in a patient with BRCA1 breast cancer. (PubMed id 18971141)1, 9 Brown J.V....Goldstein B.H. (J Minim Invasive Gynecol 2008)
    890. BRCA1 regulates human mammary stem/progenitor cell fate. (PubMed id 18230721)1, 9 Liu S....Wicha M.S. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    891. Estrogen receptor alpha, BRCA1, and FANCF promoter methylation occur in distinct subsets of sporadic breast cancers. (PubMed id 17932744)1, 9 Wei M....Olopade O.I. (Breast Cancer Res. Treat. 2008)
    892. Loss of expression of FANCD2 protein in sporadic and hereditary breast cancer. (PubMed id 17333336)1, 9 van der Groep P....van Diest P.J. (Breast Cancer Res. Treat. 2008)
    893. BRCA1 knock-down causes telomere dysfunction in mammary epithelial cells. (PubMed id 19188703)1, 9 Cabuy E....Slijepcevic P. (Cytogenet. Genome Res. 2008)
    894. Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance. (PubMed id 18413725)1, 9 Swisher E.M....Taniguchi T. (Cancer Res. 2008)
    895. Clinical classification of BRCA1 and BRCA2 DNA sequence variants: the value of cytokeratin profiles and evolutionary analysis--a report from the kConFab Investigators. (PubMed id 18375895)1, 9 Spurdle A.B....Goldgar D.E. (J. Clin. Oncol. 2008)
    896. Prolonged survival among women with BRCA germline mutations and advanced endometrial cancer: a case series. (PubMed id 17645508)1, 9 Kwon J.S....Ainsworth P. (Int. J. Gynecol. Cancer 2008)
    897. Does the nonsense-mediated mRNA decay mechanism prevent the synthesis of truncated BRCA1, CHK2, and p53 proteins? (PubMed id 17694537)1, 9 AnczukA^w O....Mazoyer S. (Hum. Mutat. 2008)
    898. Occurrence of both breast and ovarian cancer in a woman is a marker for the BRCA gene mutations: a population-based study from western Sweden. (PubMed id 16944270)1, 9 Einbeigi Z....Karlsson P. (Fam. Cancer 2007)
    899. Estrogen receptor alpha is a putative substrate for the BRCA1 ubiquitin ligase. (PubMed id 17392432)1, 9 Eakin C.M....Klevit R.E. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    900. Identification and in silico analysis of functional SNPs of the BRCA1 gene. (PubMed id 17719744)1, 9 Rajasekaran R....Sethumadhavan R. (Genomics 2007)
    901. Effects of BRCA1 transgene expression on murine mammary gland development and mutagen-induced mammary neoplasia. (PubMed id 17505536)1, 9 Hoshino A....Jensen R.A. (Int. J. Biol. Sci. 2007)
    902. BRCA1a has antitumor activity in TN breast, ovarian and prostate cancers. (PubMed id 17384678)1, 9 Yuli C....Rao V.N. (Oncogene 2007)
    903. FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein. (PubMed id 17596542)1, 9 Gupta R....Brosh R.M. (Blood 2007)
    904. Ubiquitination and proteasome-mediated degradation of BRCA1 and BARD1 during steroidogenesis in human ovarian granulosa cells. (PubMed id 17185394)1, 9 Lu Y....Hu Y. (Mol. Endocrinol. 2007)
    905. The BRCA1/2 pathway prevents hematologic cancers in addition to breast and ovarian cancers. (PubMed id 17683622)1, 9 Friedenson B. (BMC Cancer 2007)
    906. Tumor suppressor BRCA1 inhibits a breast cancer-associated promoter of the aromatase gene (CYP19) in human adipose stromal cells. (PubMed id 16940470)1, 9 Ghosh S....Li R. (Am. J. Physiol. Endocrinol. Metab. 2007)
    907. Identification of sequences that target BRCA1 to nuclear foci following alkylative DNA damage. (PubMed id 17531442)1, 9 Au W.W. and Henderson B.R. (Cell. Signal. 2007)
    908. Heterozygote BRCA1 status and skewed chromosome X inactivation. (PubMed id 16944269)1, 9 Helbling-Leclere A....Feunteun J. (Fam. Cancer 2007)
    909. BRCA1 regulates IFN-gamma signaling through a mechanism involving the type I IFNs. (PubMed id 17374731)1, 9 Buckley N.E....Mullan P.B. (Mol. Cancer Res. 2007)
    910. Epigenetic inactivation of the chromosomal stability control genes BRCA1, BRCA2, and XRCC5 in non-small cell lung cancer. (PubMed id 17289874)1, 9 Lee M.N....Wang Y.C. (Clin. Cancer Res. 2007)
    911. A mutation in the 5' untranslated region of the BRCA1 gene in sporadic breast cancer causes downregulation of translation efficiency. (PubMed id 17697535)1, 9 Wang J....Ma X. (J. Int. Med. Res. 2007)
    912. HIV-1 Vpr induces ATM-dependent cellular signal with enhanced homologous recombination. (PubMed id 16983346)1, 9 Nakai-Murakami C....Ishizaka Y. (Oncogene 2007)
    913. Molecular basis for estrogen receptor alpha deficiency in BRCA1-linked breast cancer. (PubMed id 18000219)1, 9 Hosey A.M....Harkin D.P. (J. Natl. Cancer Inst. 2007)
    914. Familial breast/ovarian cancer and BRCA1/2 genetic screening: the role of immunohistochemistry as an additional method in the selection of patients. (PubMed id 17625228)1, 9 Vaz F.H....AndrAc S.P. (J. Histochem. Cytochem. 2007)
    915. Substrates of the BRCA1-dependent ubiquitin ligase. (PubMed id 16479151)1, 9 Starita L.M. and Parvin J.D. (amp 2006)
    916. Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes. (PubMed id 16391231)1, 9 Greenberg R.A....Livingston D.M. (amp 2006)
    917. Genetic instability of BRCA1 gene at locus D17S855 is related to clinicopathological behaviors of gastric cancer from Chinese population. (PubMed id 16830385)1, 9 Chen X.R....Wang J.W. (World J. Gastroenterol. 2006)
    918. New role for nuclear hormone receptors and coactivators in regulation of BRCA1-mediated DNA repair in breast cancer cell lines. (PubMed id 16417649)1, 9 Crowe D.L. and Lee M.K. (Breast Cancer Res. 2006)
    919. BRCA1 suppresses osteopontin-mediated breast cancer. (PubMed id 16807234)1, 9 El-Tanani M.K....Rudland P.S. (J. Biol. Chem. 2006)
    920. Missense mutations of BRCA1 gene affect the binding with p53 both in vitro and in vivo. (PubMed id 16969499)1, 9 Quaresima B....Venuta S. (Oncol. Rep. 2006)
    921. Lack of germ-line promoter methylation in BRCA1-negative families with familial breast cancer. (PubMed id 17253935)1, 9 Chen Y....Ziegler J.L. (Genet. Test. 2006)
    922. A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites. (PubMed id 16628214)1, 9 Polanowska J....Boulton S.J. (EMBO J. 2006)
    923. BRCA1 negatively regulates the cancer-associated aromatase promoters I.3 and II in breast adipose fibroblasts and malignant epithelial cells. (PubMed id 16940443)1, 9 Lu M....Bulun S.E. (J. Clin. Endocrinol. Metab. 2006)
    924. Pathology and gene expression of hereditary breast tumors associated with BRCA1, BRCA2 and CHEK2 gene mutations. (PubMed id 16998498)1, 9 Honrado E....Benitez J. (Oncogene 2006)
    925. BRCA1/BARD1 ubiquitinate phosphorylated RNA polymerase II. (PubMed id 15886201)1, 9 Starita L.M....Chiba N. (J. Biol. Chem. 2005)
    926. Structural determinants of the BRCA1 : estrogen receptor interaction. (PubMed id 15674350)1, 9 Ma Y.X....Rosen E.M. (Oncogene 2005)
    927. Understanding breast cancer risk -- where do we stand in 2005? (PubMed id 15784178)1, 9 Dumitrescu R.G. and Cotarla I. (J. Cell. Mol. Med. 2005)
    928. BRCA1 and c-Myc associate to transcriptionally repress psoriasin, a DNA damage-inducible gene. (PubMed id 16288014)1, 9 Kennedy R.D....Harkin D.P. (Cancer Res. 2005)
    929. BRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II. (PubMed id 15905410)1, 9 Kleiman F.E....Manley J.L. (amp 2005)
    930. Use of adenoviral E1A protein to analyze K18 promoter deregulation in colon carcinoma cells discloses a role for CtBP1 and BRCA1. (PubMed id 15831101)1, 9 Delouis C....Brison O. (BMC Mol. Biol. 2005)
    931. [Genetic instability on chromosome 17q21 in gastric cancer of Chinese patients]. (PubMed id 16011248)1, 9 Lin X.Q....Li J.C. (Shi Yan Sheng Wu Xue Bao 2005)
    932. Structural basis for cell cycle checkpoint control by the BRCA1-CtIP complex. (PubMed id 16101277)2, 9 Varma A.K.... Ladias J.A. (Biochemistry 2005)
    933. High proportion of recurrent germline mutations in the BRCA1 gene in breast and ovarian cancer patients from the Prague area. (PubMed id 16168118)1, 9 Pohlreich P....Matous B. (Breast Cancer Res. 2005)
    934. An amino-terminal motif functions as a second nuclear export sequence in BRCA1. (PubMed id 15811849)1, 9 Thompson M.E....Holt J.T. (J. Biol. Chem. 2005)
    935. Centrosomal microtubule nucleation activity is inhibited by BRCA1-dependent ubiquitination. (PubMed id 16166645)1, 9 Sankaran S....Parvin J.D. (Mol. Cell. Biol. 2005)
    936. Recent developments in critical genes in the molecular biology of breast cancer. (PubMed id 15691805)1, 9 Sunpaweravong S. and Sunpaweravong P. (Asian J Surg 2005)
    937. Hyperphosphorylation of the BARD1 tumor suppressor in mitotic cells. (PubMed id 15855157)1, 9 Choudhury A.D....Baer R. (J. Biol. Chem. 2005)
    938. BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number. (PubMed id 15367667)1, 9 Starita L.M....Parvin J.D. (Mol. Cell. Biol. 2004)
    939. MYC is amplified in BRCA1-associated breast cancers. (PubMed id 14760071)1, 9 Grushko T.A....Olopade O.I. (Clin. Cancer Res. 2004)
    940. Fidelity of DNA double-strand break repair in heterozygous cell lines harbouring BRCA1 missense mutations. (PubMed id 14647443)1, 9 Coupier I....Stoppa-Lyonnet D. (Oncogene 2004)
    941. Mass spectrometric and mutational analyses reveal Lys-6-linked polyubiquitin chains catalyzed by BRCA1-BARD1 ubiquitin ligase. (PubMed id 14638690)1, 9 Nishikawa H....Ohta T. (J. Biol. Chem. 2004)
    942. Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. (PubMed id 15220350)1, 9 Xu X.... Stern D.F. (J. Biol. Chem. 2004)
    943. BRCA1 inhibits membrane estrogen and growth factor receptor signaling to cell proliferation in breast cancer. (PubMed id 15199145)1, 9 Razandi M....Levin E.R. (Mol. Cell. Biol. 2004)
    944. Is systemic disease in the coelomic epithelium associated with BRCA1 germline mutations? (PubMed id 15026477)4, 9 Pautier P....Spatz A. (J. Natl. Cancer Inst. 2004)
    945. [A paradox and three egnimas about the role of BRCA1 in breast and ovarian cancers]. (PubMed id 15368961)1, 9 Feunteun J. (J. Soc. Biol. 2004)
    946. BRCA1 in hormone-responsive cancers. (PubMed id 14516936)1, 9 Rosen E.M....Goldberg I.D. (Trends Endocrinol. Metab. 2003)
    947. BRCA1 gene in breast cancer. (PubMed id 12767038)1, 9 Rosen E.M....Goldberg I.D. (J. Cell. Physiol. 2003)
    948. A mutation analysis of the BRCA1 gene in 140 families from southeast France with a history of breast and/or ovarian cancer. (PubMed id 12827452)1, 9 Rostagno P....Frenay M. (J. Hum. Genet. 2003)
    949. Negative regulation of BRCA1 gene expression by HMGA1 proteins accounts for the reduced BRCA1 protein levels in sporadic breast carcinoma. (PubMed id 12640109)1, 9 Baldassarre G....Fusco A. (Mol. Cell. Biol. 2003)
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