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BRAT1 Gene

protein-coding   GIFtS: 50
GCID: GC07M002577

BRCA1-Associated ATM Activator 1

(Previous name: chromosome 7 open reading frame 27)
(Previous symbols: C7orf27, BAAT1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
BRCA1-Associated ATM Activator 11 2     RMFSL2 5
BAAT11 2 3 5     Chromosome 7 Open Reading Frame 271
C7orf271 2 3 5     HEAT Repeat-Containing Protein C7orf272
BRCA1-Associated Protein Required For ATM Activation Protein 11 2 3     

External Ids:    HGNC: 217011   Entrez Gene: 2219272   Ensembl: ENSG000001060097   OMIM: 6145065   UniProtKB: Q6PJG63   

Export aliases for BRAT1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BRAT1 Gene:
The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer
1) protein and and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of
cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as
double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex
BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role
in the DNA damage pathway regulated by BRCA1 and ATM. (provided by RefSeq, Mar 2012)

GeneCards Summary for BRAT1 Gene:
BRAT1 (BRCA1-associated ATM activator 1) is a protein-coding gene. Diseases associated with BRAT1 include rigidity and multifocal seizure syndrome, lethal neonatal, and ataxia telangiectasia.

UniProtKB/Swiss-Prot: BRAT1_HUMAN, Q6PJG6
Function: Required for activation of ATM following ionizing radiation. May act by regulating dephosphorylation of
ATM




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007819.18  NC_018918.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for BRAT1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): BRAT1 promoter sequence
   Search Chromatin IP Primers for BRAT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BRAT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.3   Ensembl cytogenetic band:  7p22.3   HGNC cytogenetic band: 7p22.3

BRAT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRAT1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M002577:  view genomic region     (about GC identifiers)

Start:
2,577,444 bp from pter      End:
2,595,392 bp from pter
Size:
17,949 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 2,625,313-2,643,304     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BRAT1_HUMAN, Q6PJG6 (See protein sequence)
Recommended Name: BRCA1-associated ATM activator 1  
Size: 821 amino acids; 88119 Da
Subunit: Interacts with BRCA1 and ATM
Sequence caution: Sequence=BAB15772.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for BRAT1:
4IFI (3D)    
Secondary accessions: A4D200 C9JY24 Q8IW85 Q8IZ43 Q8WVR8 Q96IV9 Q9H7J8 Q9UFA3
Alternative splicing: 3 isoforms:  Q6PJG6-1   Q6PJG6-2   Q6PJG6-3   (No experimental confirmation available. Ref.5 (AAH40704) sequence is in conflict in position: 49:P->T)

Explore the universe of human proteins at neXtProt for BRAT1: NX_Q6PJG6

Explore proteomics data for BRAT1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys31, Lys197, Lys213, Lys304, Lys329, Lys358, Lys507, Lys729
  • Modification sites at PhosphoSitePlus

  • See BRAT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689956.2  
    ENSEMBL proteins: 
     ENSP00000339637   ENSP00000409209  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR011989 ARM-like
     IPR000357 HEAT
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q6PJG6

    ProtoNet protein and cluster: Q6PJG6

    UniProtKB/Swiss-Prot: BRAT1_HUMAN, Q6PJG6
    Similarity: Contains 2 HEAT repeats


    BRAT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BRAT1_HUMAN, Q6PJG6
    Function: Required for activation of ATM following ionizing radiation. May act by regulating dephosphorylation of
    ATM

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI16452482
         
    BRAT1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for BRAT1:
     Increased gamma-H2AX phosphory 

    Animal Models:
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    Block miRNA regulation of human, mouse, rat BRAT1 using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BRAT1_HUMAN, Q6PJG6: Nucleus. Note=Present at double strand breaks (DSBs) following ionizing radiation treatment

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16452482

    BRAT1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BRAT1
    Interactions:

        Search GeneGlobe Interaction Network for BRAT1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for BRAT1 (Q6PJG63 ENSP000003396374) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    SUMO2ENSP000004059654STRING: ENSP00000405965
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010212response to ionizing radiation IMP16452482

    BRAT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BRAT1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for BRAT1 gene: 
    NM_152743.3  

    Unigene Cluster for BRAT1:

    BRCA1-associated ATM activator 1
    Hs.520623  [show with all ESTs]
    Unigene Representative Sequence: NM_152743
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340611(uc003smi.3) ENST00000493232 ENST00000467558 ENST00000469750(uc003smh.4 uc003smj.2)
    ENST00000473879 ENST00000421712
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat BRAT1

    Additional mRNA sequence: 

    AL133088.1 BC007209.1 BC015632.2 BC023561.2 

    9 DOTS entries:

    DT.91746684  DT.95319778  DT.95319768  DT.95319767  DT.101983036  DT.100791018  DT.100791016  DT.121111633 
    DT.97859408 

    208 AceView cDNA sequences (see top 24):

    BM916568 AI394324 AW005320 BQ045151 NM_152743 BM675122 BX284041 BM931086 
    BQ951743 F34658 AL525642 BM694411 BE303038 AA078181 BC023561 BI335238 
    CR604410 BC015632 BM543881 BC007209 BE043101 BQ026094 AI572883 AI678002 
    BM564506 AI275736 BM825687 BF726952 BE247601 AA112910 BU556454 BQ427534 
    CB216768 BE043102 BU731056 BI117382 BM021553 BM912732 CF125040 CD722594 
    BE783629 BM970795 BI836516 BF969872 AA282249 BI824049 AA323423 AW976249 
    BU520780 AL536228 BM543701 AI025536 AI680971 BE733103 AI081542 BM560930 
    CB306014 AI983711 AA489662 AL525593 BM553644 AA476896 AI478967 AI246012 
    BU618152 AL602701 BQ641846 BI963810 AW270148 AL529639 BI520560 BU618376 
    BG422996 AI627352 AA778081 BU681331 BG678287 AL520479 BX417297 AI185415 
    BP363179 BF526009 BG333717 CN483013 BM922941 AL529638 AK024461 BF530824 
    AI739371 BI011313 BM052835 BM194038 BQ955587 BC040704 CA444233 BI964092 
    BU632954 AA490193 BM009979 BI912723 BE276637 BG764920 BE744900 BM790985 
    AL528965 AL554148 BF315512 CA312835 BU520999 BF984964 AK131083 CK903750 
    AW015987 BQ688708 BG177420 BG912901 AI963076 BX400230 AA578649 BM045207 
    BQ962767 BF340204 BQ431519 BI603958 BF726951 AI682781 AK024482 AW754500 
    BI260965 BV205685 AI268916 CD369082 AA284844 BQ431838 BF683471 BQ438799 
    CA423838 AK131097 AA748590 AL133088 BF972673 CK904357 BX436709 BG403468 
    BU166985 AL531485 BM053146 CF529021 AA969391 BI757040 AI684273 BE646339 
    BF529026 BG340236 BI771790 AA282722 BF732944 BF732535 C17837 AW510663 
    BE855841 AW339242 BF347695 BE896377 BX461553 H17234 AL576948 CB987976 
    AL580785 BM983482 BM791702 AL044166 AI192956 AA100311 AL520478 BE886527 
    AI082011 BG914248 BE549624 AL559089 CB269191 BG912580 BI918340 AL039819 
    T16148 AW028418 BG179113 AA284609 BE884662 BG481753 AW439100 CD671900 
    H17127 BI257350 AL563300 CD251884 AL531484 BM477906 CK903749 BQ427578 
    BF913055 BE697518 AL566245 BM010932 BM555599 BF124939 BG259877 BG762603 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for BRAT1 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^
    SP1:                          -     -                                                                       -                 -                             -   
    SP2:                          -     -                                                                       -                 -                                 
    SP3:                                                                                                                          -                                 
    SP4:                                                                                      -     -           -                 -                                 
    SP5:                                                                                                        -                                                   

    ExUns: 15 ^ 16 ^ 17 ^ 18a · 18b
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for BRAT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BRAT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTTCTGTG
    BRAT1 Expression
    About this image

    BRAT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BRAT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.520623

    UniProtKB/Swiss-Prot: BRAT1_HUMAN, Q6PJG6
    Tissue specificity: Ubiquitously expressed

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for BRAT1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Brat11 , 5 BRCA1-associated ATM activator 11, 5 77.67(n)1
    73.69(a)1
      5 (79.25 cM)5
    2318411  NM_001276287.11  NP_001263216.11 
     1407050115 
    chicken
    (Gallus gallus)
    Aves BRAT11 BRCA1-associated ATM activator 1 55.88(n)
    49.32(a)
      769893  XM_001233205.3  XP_001233206.3 
    lizard
    (Anolis carolinensis)
    Reptilia BRAT16
    BRCA1-associated ATM activator 1
    48(a)
    1 ↔ 1
    GL343340.1(364815-375725)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia brat11 BRCA1-associated ATM activator 1 49.29(n)
    42.72(a)
      100494213  XM_002932224.2  XP_002932270.2 
    zebrafish
    (Danio rerio)
    Actinopterygii brat11 BRCA1-associated ATM activator 1 47.2(n)
    37.55(a)
      678547  NM_001040305.1  NP_001035395.1 


    ENSEMBL Gene Tree for BRAT1 (if available)
    TreeFam Gene Tree for BRAT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BRAT1 gene
    3 SIMAP similar genes for BRAT1 using alignment to 2 protein entries:     BRAT1_HUMAN (see all proteins):
    FLJ00053    FLJ00283    FLJ00321

    BRAT1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BRAT1 (see all 743)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1479784141,2
    Cuntested12554279(+) CCCCAA/C/GGAAGT 2 L syn10--------
    rs1458483081,2
    --2550292(+) AAACTC/GCTGGC 1 -- ds50010--------
    rs1490161841,2
    --2550301(+) GCCTTA/GAACAA 1 -- ds50010--------
    rs1123512571,2
    C--2550327(+) CTCCCG/AAAGTG 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1926556411,2
    --2550403(+) CCGGGC/TGGAGT 1 -- ds50010--------
    rs1838825351,2
    --2550529(+) AAAAAA/TATTAG 1 -- ds50010--------
    rs1893402551,2
    --2550570(+) AGCTAC/TTCGGG 1 -- ds50010--------
    rs1420543441,2
    --2550673(+) GAAACC/TCCATC 1 -- ds50010--------
    rs1819554591,2
    --2550699(+) ACAGAC/TAGATA 1 -- ds50010--------
    rs1859165581,2
    --2550798(+) TAACTC/GAAAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for BRAT1 (2577444 - 2595392 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for BRAT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv887298CNV Loss21882294
    dgv7117n71CNV Loss21882294
    dgv7118n71CNV Loss21882294
    nsv887297CNV Loss21882294
    nsv830887CNV Loss17160897
    dgv7120n71CNV Loss21882294
    dgv7116n71CNV Loss21882294
    dgv7119n71CNV Loss21882294
    nsv823981CNV Gain20364138

    Human Gene Mutation Database (HGMD): BRAT1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BRAT1
    DNA2.0 Custom Variant and Variant Library Synthesis for BRAT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614506   
    OMIM disorders: 614498  
    UniProtKB/Swiss-Prot: BRAT1_HUMAN, Q6PJG6
  • Rigidity and multifocal seizure syndrome, lethal neonatal (RMFSL) [MIM:614498]: A lethal, neonatal,
    neurologic disorder characterized by episodic jerking that is apparent in utero, lack of psychomotor development,
    axial and limb rigidity, frequent multifocal seizures, and dysautonomia. At birth, affected individuals have
    small heads, overlapping cranial sutures, small or absent fontanels, and depressed frontal bones. Infants show
    poorly responsive focal jerks of the tongue, face and arms in a nearly continuous sequence throughout life.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 8 diseases for BRAT1:    
    About MalaCards
    rigidity and multifocal seizure syndrome, lethal neonatal    ataxia telangiectasia    dysautonomia    ataxia
    breast cancer    obesity    multiple myeloma    myeloma


    BRAT1 for disorders           About GeneDecksing


    Export disorders for BRAT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BRAT1 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with BRAT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ATM activation by ionizing radiation requires BRCA1-associated BAAT1. (PubMed id 16452482)1, 2, 3 Aglipay J.A.... Ouchi T. (J. Biol. Chem. 2006)
    2. Genetic mapping and exome sequencing identify variants associated with five novel diseases. (PubMed id 22279524)1, 2 Puffenberger E.G....Strauss K.A. (PLoS ONE 2012)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    7. Structural basis for the BRCA1 BRCT interaction with the proteins ATRIP and BAAT1. (PubMed id 24073851)1 Liu X. and Ladias J.A. (Biochemistry 2013)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 221927 HGNC: 21701 AceView: C7orf27 Ensembl:ENSG00000106009 euGenes: HUgn221927
    ECgene: BRAT1 H-InvDB: BRAT1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for BRAT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for BRAT1 gene:
    Search GeneIP for patents involving BRAT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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