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BRAT1 Gene

protein-coding GIFtS: 50
GCID: GC07M002577

BRCA1-Associated ATM Activator 1

(Previous name: chromosome 7 open reading frame 27)
(Previous symbols: C7orf27, BAAT1)

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
BRCA1-Associated ATM Activator 1¹ ²		RMFSL² ⁵
BAAT1¹ ² ³ ⁵		Chromosome 7 Open Reading Frame 27¹
C7orf27¹ ² ³ ⁵		HEAT Repeat-Containing Protein C7orf27²
BRCA1-Associated Protein Required For ATM Activation Protein 1¹ ² ³

External Ids:	HGNC: 21701¹	Entrez Gene: 221927²	Ensembl: ENSG00000106009⁷	OMIM: 614506⁵	UniProtKB: Q6PJG6³

Export aliases for BRAT1 gene to outside databases

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BRAT1 Gene:

The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer

1) protein and and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of

cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as

double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex

BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role

in the DNA damage pathway regulated by BRCA1 and ATM. (provided by RefSeq, Mar 2012)

GeneCards Summary for BRAT1 Gene:

BRAT1 (BRCA1-associated ATM activator 1) is a protein-coding gene. Diseases associated with BRAT1 include rigidity and multifocal seizure syndrome, lethal neonatal, and ataxia telangiectasia.

UniProtKB/Swiss-Prot: BRAT1_HUMAN, Q6PJG6

Function: Required for activation of ATM following ionizing radiation. May act by regulating dephosphorylation of

ATM

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000007.14 NT_007819.18 NC_018918.2

Regulatory elements:

Search for regulatory transcription factor binding sites for BRAT1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): BRAT1 promoter sequence

Search Chromatin IP Primers for BRAT1

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BRAT1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.3 Ensembl cytogenetic band: 7p22.3 HGNC cytogenetic band: 7p22.3

BRAT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRAT1 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M002577: view genomic region (about GC identifiers)

Start:	2,577,444 bp from pter	End:	2,595,392 bp from pter
Size:	17,949 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 2,625,313-2,643,304

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: BRAT1_HUMAN, Q6PJG6 (See protein sequence)

Recommended Name: BRCA1-associated ATM activator 1

Size: 821 amino acids; 88119 Da

Subunit: Interacts with BRCA1 and ATM

Sequence caution: Sequence=BAB15772.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

1 PDB 3D structure from and Proteopedia for BRAT1:

4IFI (3D)

Secondary accessions: A4D200 C9JY24 Q8IW85 Q8IZ43 Q8WVR8 Q96IV9 Q9H7J8 Q9UFA3

Alternative splicing: 3 isoforms: Q6PJG6-1 Q6PJG6-2 Q6PJG6-3 (No experimental confirmation available. Ref.5 (AAH40704) sequence is in conflict in position: 49:P->T)

Explore the universe of human proteins at neXtProt for BRAT1: NX_Q6PJG6

Explore proteomics data for BRAT1 at MOPED

Post-translational modifications:

Ubiquitination² at Lys31, Lys197, Lys213, Lys304, Lys329, Lys358, Lys507, Lys729

Modification sites at PhosphoSitePlus

See BRAT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_689956.2

ENSEMBL proteins:

ENSP00000339637 ENSP00000409209

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro protein domains:

IPR011989 ARM-like

IPR000357 HEAT

IPR016024 ARM-type_fold

Graphical View of Domain Structure for InterPro Entry Q6PJG6

ProtoNet protein and cluster: Q6PJG6

UniProtKB/Swiss-Prot: BRAT1_HUMAN, Q6PJG6

Similarity: Contains 2 HEAT repeats

BRAT1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: BRAT1_HUMAN, Q6PJG6

Function: Required for activation of ATM following ionizing radiation. May act by regulating dephosphorylation of

ATM

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005488	binding	--	--
GO:0005515	protein binding	IPI	16452482

BRAT1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for BRAT1:

Increased gamma-H2AX phosphory

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BRAT1

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genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BRAT1

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Gene Editing
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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

BRAT1_HUMAN, Q6PJG6: Nucleus. Note=Present at double strand breaks (DSBs) following ionizing radiation treatment

Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	16452482

BRAT1 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for BRAT1
Interactions:

Search GeneGlobe Interaction Network for BRAT1

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for BRAT1 (Q6PJG6³ ENSP00000339637⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818
SUMO2	ENSP00000405965⁴	STRING: ENSP00000405965

About this table

Gene Ontology (GO): 1 biological process term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0010212	response to ionizing radiation	IMP	16452482

BRAT1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for BRAT1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for BRAT1 gene:

NM_152743.3

Unigene Cluster for BRAT1:

BRCA1-associated ATM activator 1

Hs.520623 [show with all ESTs]

Unigene Representative Sequence: NM_152743

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000340611(uc003smi.3) ENST00000493232 ENST00000467558 ENST00000469750(uc003smh.4 uc003smj.2)

ENST00000473879 ENST00000421712

miRNA Products:		Block miRNA regulation of human, mouse, rat BRAT1 using miScript Target Protectors
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		Predesigned siRNA for gene silencing in human, mouse, rat BRAT1

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Additional mRNA sequence:

AL133088.1 BC007209.1 BC015632.2 BC023561.2

9 DOTS entries:

DT.91746684 DT.95319778 DT.95319768 DT.95319767 DT.101983036 DT.100791018 DT.100791016 DT.121111633

DT.97859408

Selected AceView cDNA sequences (see all 208):

BM916568 AI394324 AW005320 BQ045151 NM_152743 BM675122 BX284041 BM931086

BQ951743 F34658 AL525642 BM694411 BE303038 AA078181 BC023561 BI335238

CR604410 BC015632 BM543881 BC007209 BE043101 BQ026094 AI572883 AI678002

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for BRAT1 (see all 13) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	·	7c	·	7d	·	7e	^	8a	·	8b	·	8c	^	9	^	10a	·	10b	^	11	^	12a	·	12b	·	12c	^	13a	·	13b	^	14	^
SP1:									-		-																								-						-										-
SP2:									-		-																								-						-
SP3:																																									-
SP4:																													-		-				-						-
SP5:																																			-

ExUns:	15	^	16	^	17	^	18a	·	18b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for BRAT1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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BRAT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TCCTTCTGTG

About this image

BRAT1 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

BRAT1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.520623

UniProtKB/Swiss-Prot: BRAT1_HUMAN, Q6PJG6

Tissue specificity: Ubiquitously expressed

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRAT1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for BRAT1 gene from Selected species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Brat1^{1 , 5}	BRCA1-associated ATM activator 1^{1, 5}	77.67(n)¹ 73.69(a)¹		5 (79.25 cM)⁵ 231841¹ NM_001276287.1¹ NP_001263216.1¹ 140705011⁵
chicken (Gallus gallus)	Aves	BRAT1¹	BRCA1-associated ATM activator 1	55.88(n) 49.32(a)		769893 XM_001233205.3 XP_001233206.3
lizard (Anolis carolinensis)	Reptilia	BRAT1⁶	BRCA1-associated ATM activator 1	48(a)	1 ↔ 1	GL343340.1(364815-375725)
tropical clawed frog (Xenopus tropicalis)	Amphibia	brat1¹	BRCA1-associated ATM activator 1	49.29(n) 42.72(a)		100494213 XM_002932224.2 XP_002932270.2
zebrafish (Danio rerio)	Actinopterygii	brat1¹	BRCA1-associated ATM activator 1	47.2(n) 37.55(a)		678547 NM_001040305.1 NP_001035395.1

ENSEMBL Gene Tree for BRAT1 (if available)
TreeFam Gene Tree for BRAT1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for BRAT1 gene

3 SIMAP similar genes for BRAT1 using alignment to 2 protein entries: BRAT1_HUMAN (see all proteins):

FLJ00053 FLJ00283 FLJ00321

BRAT1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147978414^1,2	C	untested¹	2554279(+)	`CCCCAA/C/GGAAGT`	2	L	syn¹		0	--	--	--	--
rs145848308^1,2		--	2550292(+)	`AAACTC/GCTGGC`	1	--	ds500¹		0	--	--	--	--
rs149016184^1,2		--	2550301(+)	`GCCTTA/GAACAA`	1	--	ds500¹		0	--	--	--	--
rs112351257^1,2	C	--	2550327(+)	`CTCCCG/AAAGTG`	1	--	ds500¹		1		CSA	2
rs192655641^1,2		--	2550403(+)	`CCGGGC/TGGAGT`	1	--	ds500¹		0	--	--	--	--
rs183882535^1,2		--	2550529(+)	`AAAAAA/TATTAG`	1	--	ds500¹		0	--	--	--	--
rs189340255^1,2		--	2550570(+)	`AGCTAC/TTCGGG`	1	--	ds500¹		0	--	--	--	--
rs142054344^1,2		--	2550673(+)	`GAAACC/TCCATC`	1	--	ds500¹		0	--	--	--	--
rs181955459^1,2		--	2550699(+)	`ACAGAC/TAGATA`	1	--	ds500¹		0	--	--	--	--
rs185916558^1,2		--	2550798(+)	`TAACTC/GAAAAA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for BRAT1 (2577444 - 2595392 bp)

Structural Variations
Database of Genomic Variants (DGV) 9 variations for BRAT1: About this table

Variant ID	Type	Subtype	PubMed ID
nsv887298	CNV	Loss	21882294
dgv7117n71	CNV	Loss	21882294
dgv7118n71	CNV	Loss	21882294
nsv887297	CNV	Loss	21882294
nsv830887	CNV	Loss	17160897
dgv7120n71	CNV	Loss	21882294
dgv7116n71	CNV	Loss	21882294
dgv7119n71	CNV	Loss	21882294
nsv823981	CNV	Gain	20364138

Human Gene Mutation Database (HGMD): BRAT1

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing BRAT1

DNA2.0 Custom Variant and Variant Library Synthesis for BRAT1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 614506
OMIM disorders: 614498
UniProtKB/Swiss-Prot: BRAT1_HUMAN, Q6PJG6

Rigidity and multifocal seizure syndrome, lethal neonatal (RMFSL) [MIM:614498]: A lethal, neonatal,

neurologic disorder characterized by episodic jerking that is apparent in utero, lack of psychomotor development,

axial and limb rigidity, frequent multifocal seizures, and dysautonomia. At birth, affected individuals have

small heads, overlapping cranial sutures, small or absent fontanels, and depressed frontal bones. Infants show

poorly responsive focal jerks of the tongue, face and arms in a nearly continuous sequence throughout life.

Note=The disease is caused by mutations affecting the gene represented in this entry

8 diseases for BRAT1: About MalaCards

rigidity and multifocal seizure syndrome, lethal neonatal ataxia telangiectasia dysautonomia ataxia

breast cancer obesity multiple myeloma myeloma

BRAT1 for disorders About GeneDecksing

Export disorders for BRAT1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for BRAT1 gene, integrated from 10 sources (see all 30):
(articles sorted by number of sources associating them with BRAT1)

Utopia: connect your pdf to the dynamic
world of online information

ATM activation by ionizing radiation requires BRCA1-associated BAAT1. (PubMed id 16452482)^{1, 2, 3} Aglipay J.A.... Ouchi T. (J. Biol. Chem. 2006)
Genetic mapping and exome sequencing identify variants associated with five novel diseases. (PubMed id 22279524)^{1, 2} Puffenberger E.G....Strauss K.A. (PLoS ONE 2012)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)¹ Yu C.C....Chow L.P. (PLoS ONE 2013)
Structural basis for the BRCA1 BRCT interaction with the proteins ATRIP and BAAT1. (PubMed id 24073851)¹ Liu X. and Ladias J.A. (Biochemistry 2013)
Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)¹ Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (amp 2012)
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)¹ Comuzzie A.G....Butte N.F. (PLoS ONE 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 221927	HGNC: 21701	AceView: C7orf27	Ensembl:ENSG00000106009	euGenes: HUgn221927
ECgene: BRAT1	H-InvDB: BRAT1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for BRAT1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for BRAT1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for BRAT1 gene:
Search GeneIP for patents involving BRAT1

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Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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BRAT1 Gene

BRCA1-Associated ATM Activator 1

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BRAT1 Gene

BRCA1-Associated ATM Activator 1

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