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BRAP Gene

protein-coding   GIFtS: 58
GCID: GC12M112080

BRCA1 Associated Protein

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
BRCA1 Associated Protein1 2     Renal Carcinoma Antigen NY-REN-632 3
Impedes Mitogenic Signal Propagation1 2 3     RNF522 3
BRAP22 3 5     RING Finger Protein 522 3
IMP2 3 5     BRCA1-Associated Protein2
Galectin-2-Binding Protein1 2     EC 6.3.2.-3

External Ids:    HGNC: 10991   Entrez Gene: 83152   Ensembl: ENSG000000892347   OMIM: 6049865   UniProtKB: Q7Z5693   

Export aliases for BRAP gene to outside databases

Previous GC identifers: GC12M110940 GC12U900022 GC12M111864 GC12M110493 GC12M110544 GC12M109093


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BRAP Gene:
The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1
and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a
nuclear localization signal in the cytoplasm. (provided by RefSeq, Jul 2008)

GeneCards Summary for BRAP Gene:
BRAP (BRCA1 associated protein) is a protein-coding gene. GO annotations related to this gene include nuclear localization sequence binding and nucleotide binding.

UniProtKB/Swiss-Prot: BRAP_HUMAN, Q7Z569
Function: Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by
inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation
of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex
formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BRAP gene promoter:
         Max   Max1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBRAP promoter sequence
   Search Chromatin IP Primers for BRAP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BRAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24   Ensembl cytogenetic band:  12q24.12   HGNC cytogenetic band: 12q24

BRAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRAP gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M112080:  view genomic region     (about GC identifiers)

Start:
112,079,950 bp from pter      End:
112,123,790 bp from pter
Size:
43,841 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BRAP_HUMAN, Q7Z569 (See protein sequence)
Recommended Name: BRCA1-associated protein  
Size: 592 amino acids; 67305 Da
Subunit: Interacts with the nuclear localization signal of BRCA1 and with the N-terminal of KSR1. The C-terminal
portion of BCRA1 interacts with DDB1
Sequence caution: Sequence=AAC24200.1; Type=Frameshift; Positions=556;
Secondary accessions: B9EGS8 O43238 O75341

Explore the universe of human proteins at neXtProt for BRAP: NX_Q7Z569

Explore proteomics data for BRAP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys381, Lys385, Lys580
  • Modification sites at PhosphoSitePlus

  • See BRAP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006759.3  
    ENSEMBL proteins: 
     ENSP00000403524   ENSP00000330813   ENSP00000441659  

    BRAP Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
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    Search eBioscience for ELISAs for BRAP 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    5 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR012677 Nucleotide-bd_a/b_plait
     IPR011422 BRAP2
     IPR001607 Znf_UBP

    Graphical View of Domain Structure for InterPro Entry Q7Z569

    ProtoNet protein and cluster: Q7Z569

    3 Blocks protein domains:
    IPB001607 Zn-finger in ubiquitin thiolesterase
    IPB001841 Zn-finger
    IPB011422 BRCA1-associated 2


    UniProtKB/Swiss-Prot: BRAP_HUMAN, Q7Z569
    Similarity: Contains 1 RING-type zinc finger
    Similarity: Contains 1 UBP-type zinc finger


    Find genes that share domains with BRAP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BRAP_HUMAN, Q7Z569
    Function: Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by
    inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation
    of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex
    formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0004842ubiquitin-protein ligase activity IDA14724641
    GO:0005515protein binding IPI14724641
    GO:0008139nuclear localization sequence binding IDA9497340
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with BRAP           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Brap):
     cellular  embryogenesis  growth/size/body  mortality/aging  nervous system 

    Find genes that share phenotypes with BRAP           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Braptm1.1Yfng for BRAP

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BRAP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for BRAP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BRAP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BRAP

    miRNA
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    miRTarBase miRNAs that target BRAP:
    hsa-mir-1296-5p (MIRT036070), hsa-mir-221-3p (MIRT003364)

    Block miRNA regulation of human, mouse, rat BRAP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BRAP (see all 34):
    hsa-miR-1224-3p hsa-miR-30d hsa-miR-30a hsa-miR-520g hsa-miR-4280 hsa-miR-181b hsa-miR-3163 hsa-miR-1266
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat BRAP

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: BRAP (NM_006768)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat BRAP

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRAP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BRAP_HUMAN, Q7Z569: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3
    mitochondrion2
    peroxisome2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IDA14724641
    GO:0005737cytoplasm IDA--
    GO:0031965nuclear membrane IDA--

    Find genes that share ontologies with BRAP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BRAP About    
    See pathways by source

    SuperPathContained pathways About
    1Ras signaling pathway
    Ras signaling pathway0.36


    Find genes that share SuperPaths with BRAP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for BRAP):
        Ras signaling pathway

    UniProtKB/Swiss-Prot: BRAP_HUMAN, Q7Z569
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including BRAP: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BRAP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BRAP (Q7Z5691, 2, 3 ENSP000003308134) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRCA1P383981, 2, 3, ENSP000003502834EBI-349900,EBI-349905 MINT-16087 MINT-16089 MINT-16088 I2D: score=5 STRING: ENSP00000350283
    HRASP011121, 3, ENSP000003098454EBI-349900,EBI-350145 I2D: score=4 STRING: ENSP00000309845
    ARIH1Q9Y4X53, ENSP000003692174I2D: score=4 STRING: ENSP00000369217
    KSR1Q8IVT53, ENSP000002687634I2D: score=3 STRING: ENSP00000268763
    CNKSR1Q969H43, ENSP000003546094I2D: score=2 STRING: ENSP00000354609
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade IDA14724641
    GO:0007265Ras protein signal transduction IDA14724641
    GO:0009968negative regulation of signal transduction IDA14724641
    GO:0016567protein ubiquitination IDA14724641

    Find genes that share ontologies with BRAP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for BRAP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BRAP gene: 
    NM_006768.3  

    Unigene Cluster for BRAP:

    BRCA1 associated protein
    Hs.530940  [show with all ESTs]
    Unigene Representative Sequence: NM_006768
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000419234(uc010syh.2 uc009zvv.3 uc001tsn.4) ENST00000327551
    ENST00000547043 ENST00000539060
    miRNA
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    Block miRNA regulation of human, mouse, rat BRAP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate BRAP (see all 34):
    hsa-miR-1224-3p hsa-miR-30d hsa-miR-30a hsa-miR-520g hsa-miR-4280 hsa-miR-181b hsa-miR-3163 hsa-miR-1266
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: BRAP (NM_006768)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat BRAP
      QuantiTect SYBR Green Assays in human, mouse, rat BRAP
      QuantiFast Probe-based Assays in human, mouse, rat BRAP

    Additional mRNA sequence: 

    AB208878.1 AF035620.1 AF035950.1 AK290379.1 AK299326.1 AK308279.1 AY332222.1 BC136698.1 
    BC136699.1 

    9 DOTS entries:

    DT.40218228  DT.100811740  DT.121146118  DT.439536  DT.100806346  DT.91717920  DT.92430916  DT.91837542 
    DT.95086032 

    Selected AceView cDNA sequences (see all 127):

    CA867402 CK905172 BF739903 BE048293 AI817288 BM719861 CA446564 BE219978 
    CR623955 BM313750 W74280 CF127535 AA256308 BM563056 AI800021 BM676726 
    BM314024 BE389600 BM690822 AI807317 BE257286 BF432049 BM785884 AW779823 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for BRAP    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:              -                                                                     
    SP2:                                                                                    


    ECgene alternative splicing isoforms for BRAP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BRAP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGAATTTC
    BRAP Expression
    About this image

    BRAP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BRAP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.530940

    UniProtKB/Swiss-Prot: BRAP_HUMAN, Q7Z569
    Tissue specificity: Expressed in breast epithelial cell lines

        Pathway & Disease-focused RT2 Profiler PCR Array including BRAP: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRAP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for BRAP gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Brap1 , 5 BRCA1 associated protein1, 5 85.9(n)1
    91.03(a)1
      5 (61.90 cM)5
    723991  NM_028227.21  NP_082503.21 
     1216605635 
    chicken
    (Gallus gallus)
    Aves BRAP1 BRCA1 associated protein 79.76(n)
    88.18(a)
      772041  NM_001079761.1  NP_001073229.1 
    lizard
    (Anolis carolinensis)
    Reptilia BRAP6
    BRCA1 associated protein
    85(a)
    1 ↔ 1
    GL343423.1(812599-828822)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC687782 hypothetical protein MGC68778 74.67(n)    BC060490.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI984045.12   -- 80.71(n)    BI984045.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG55551 , 3 CG55551 44(a)3
    53.23(n)1
    46.7(a)1
      423021  NM_142532.31  NP_650789.11 
    worm
    (Caenorhabditis elegans)
    Secernentea EEED8.161 , 3 EEED8.161 36(a)3
    49.44(n)1
    41.01(a)1
      II(5390410-5393159)3
    1739171  NM_062615.51  NP_495016.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ETP1(YHL010C)4
    ETP11
    Putative protein of unknown function that is required more4
    ETP11
    50.71(n)1
    43.11(a)1
      8(83721-81964)4
    8563761, 4  NP_011853.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons BRIZ21 BRIZ2 49.57(n)
    39.72(a)
      817141  NM_001036342.2  NP_001031419.1 
    rice
    (Oryza sativa)
    Liliopsida AK120718.12   -- 79.16(n)    AK120718.1 


    ENSEMBL Gene Tree for BRAP (if available)
    TreeFam Gene Tree for BRAP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BRAP gene
    3 SIMAP similar genes for BRAP using alignment to 3 protein entries:     BRAP_HUMAN (see all proteins):
    USP44    USP3    TRIM39

    Find genes that share paralogs with BRAP           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BRAP (see all 857)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1409199721,2
    --112079454(+) CCTGAC/TCTCAA 1 -- ds50010--------
    rs1502711501,2
    C--112079597(+) GGAGTC/GTCGCT 1 -- ds50010--------
    rs1996302691,2
    --112079746(+) TTTTT-/TGTATTT 1 -- ds50010--------
    rs1410884841,2
    C--112079747(+) TTTTT-/GTATTT 1 -- ds50010--------
    rs766213641,2
    C,F--112079870(+) TGCCCA/GGCCGA 1 -- ds50012Minor allele frequency- G:0.08WA 120
    rs1389215491,2
    C--112079972(+) TATTTA/TAATTC 1 -- ut310--------
    rs1812439641,2
    --112080002(+) GTATGG/TGTATA 1 -- ut310--------
    rs1421871771,2
    C--112080046(+) CTTCTC/GTCTGA 1 -- ut310--------
    rs792695271,2
    C--112080100(+) AAAAAT/ATTTTT 1 -- ut311Minor allele frequency- A:0.50WA 2
    rs1888524081,2
    --112080388(+) AGACAC/TGCAAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for BRAP (112079950 - 112123790 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for BRAP: --
    Human Gene Mutation Database (HGMD): BRAP
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BRAP
    DNA2.0 Custom Variant and Variant Library Synthesis for BRAP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604986    OMIM disorders: --


    Find genes that share disorders with BRAP           About GenesLikeMe

    Genetic Association Database (GAD): BRAP
    Human Genome Epidemiology (HuGE) Navigator: BRAP (3 documents)

    Export disorders for BRAP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BRAP gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with BRAP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. SNPs in BRAP associated with risk of myocardial infarction in Asian populations. (PubMed id 19198608)1, 3, 4 Ozaki K....Tanaka T. (Nat. Genet. 2009)
    2. Identification of a novel cytoplasmic protein that specifically binds to nuclear localization signal motifs. (PubMed id 9497340)1, 2, 3 Li S.... Lee W.-H. (J. Biol. Chem. 1998)
    3. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PubMed id 20139978)1, 4 Kamatani Y....Kamatani N. (Nat. Genet. 2010)
    4. Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk. (PubMed id 19698717)1, 4 Cui R....Matsuda K. (Gastroenterology 2009)
    5. Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP. (PubMed id 14724641)1, 2 Matheny S.A....White M.A. (Nature 2004)
    6. Nuclear transport of human DDB protein induced by ultraviolet light. (PubMed id 10777491)1, 2 Liu W.... Linn S. (J. Biol. Chem. 2000)
    7. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2 Scanlan M.J....Old L.J. (Int. J. Cancer 1999)
    8. Brap2 functions as a cytoplasmic retention protein for p21 during monocyte differentiation. (PubMed id 15340083)1, 9 Asada M....Mizutani S. (Mol. Cell. Biol. 2004)
    9. The single nucleotide polymorphisms in BRAP decrease the risk of metabolic syndrome in a Chinese young adult population. (PubMed id 22965072)1 Wu L....Mi J. (amp 2013)
    10. Brap2 regulates temporal control of NF-I_B localization mediated by inflammatory response. (PubMed id 23554956)1 Takashima O....Chiba T. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8315 HGNC: 1099 AceView: BRAP Ensembl:ENSG00000089234 euGenes: HUgn8315
    ECgene: BRAP Kegg: 8315 H-InvDB: BRAP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BRAP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BRAP gene:
    Search GeneIP for patents involving BRAP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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