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Aliases for BRAP Gene

Aliases for BRAP Gene

  • BRCA1 Associated Protein 2 3 5
  • Impedes Mitogenic Signal Propagation 2 3 4
  • RING-Type E3 Ubiquitin Transferase BRAP2 3 4
  • Renal Carcinoma Antigen NY-REN-63 3 4
  • Galectin-2-Binding Protein 2 3
  • RING Finger Protein 52 3 4
  • BRAP2 3 4
  • RNF52 3 4
  • IMP 3 4
  • BRCA1-Associated Protein 3
  • EC 2.3.2.27 4

External Ids for BRAP Gene

Previous GeneCards Identifiers for BRAP Gene

  • GC12M110940
  • GC12U900022
  • GC12M111864
  • GC12M110493
  • GC12M110544
  • GC12M112080
  • GC12M109093

Summaries for BRAP Gene

Entrez Gene Summary for BRAP Gene

  • The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq, Jul 2008]

GeneCards Summary for BRAP Gene

BRAP (BRCA1 Associated Protein) is a Protein Coding gene. Among its related pathways are RET signaling and Immune System. GO annotations related to this gene include nucleotide binding and ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for BRAP Gene

  • Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRAP Gene

Genomics for BRAP Gene

Regulatory Elements for BRAP Gene

Enhancers for BRAP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F111785 0.2 ENCODE 11.3 -99.9 -99916 0.2 JUN ACAD10 BRAP GC12P111792 ALDH2
GH12F111787 0.5 ENCODE 11.2 -101.5 -101546 0.1 SOX13 ELF3 TFAP4 MXI1 SAP130 ARID4B ZSCAN9 RAD21 ZNF644 RARA ALDH2 ACAD10 BRAP GC12P111792
GH12F111788 0.7 ENCODE 11.2 -102.6 -102560 0.6 CTCF ARID4B MAX CEBPG ZNF48 ZIC2 RAD21 YY1 ZNF121 SCRT2 ALDH2 ACAD10 BRAP GC12P111792
GH12F111813 1.1 Ensembl ENCODE 10.9 -127.3 -127305 0.6 DRAP1 CTCF CBX3 ZNF146 ARID4B FEZF1 ZNF48 ZNF2 RAD21 TEAD3 ALDH2 ACAD10 BRAP GC12P111809 GC12P111836
GH12F111772 1.5 FANTOM5 Ensembl ENCODE 10.8 -89.6 -89638 6.5 PKNOX1 ATF1 ARNT ARID4B DMAP1 YY1 ZNF121 SLC30A9 ELK1 GATA2 ALDH2 ACAD10 BRAP SH2B3 FAM109A GC12P111792
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around BRAP on UCSC Golden Path with GeneCards custom track

Promoters for BRAP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001467296 196 2401 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for BRAP Gene

Chromosome:
12
Start:
111,642,146 bp from pter
End:
111,685,996 bp from pter
Size:
43,851 bases
Orientation:
Minus strand

Genomic View for BRAP Gene

Genes around BRAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRAP Gene

Proteins for BRAP Gene

  • Protein details for BRAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z569-BRAP_HUMAN
    Recommended name:
    BRCA1-associated protein
    Protein Accession:
    Q7Z569
    Secondary Accessions:
    • B4DRM1
    • B9EGS8
    • O43238
    • O75341

    Protein attributes for BRAP Gene

    Size:
    592 amino acids
    Molecular mass:
    67305 Da
    Quaternary structure:
    • Interacts with the nuclear localization signal of BRCA1 and with the N-terminal of KSR1. The C-terminal portion of BCRA1 interacts with DDB1.
    SequenceCaution:
    • Sequence=AAC24200.1; Type=Frameshift; Positions=556; Evidence={ECO:0000305};

    Alternative splice isoforms for BRAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BRAP Gene

Post-translational modifications for BRAP Gene

  • Ubiquitination at Lys 385 and Lys 580
  • Modification sites at PhosphoSitePlus

Other Protein References for BRAP Gene

No data available for DME Specific Peptides for BRAP Gene

Domains & Families for BRAP Gene

Gene Families for BRAP Gene

Suggested Antigen Peptide Sequences for BRAP Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z569

UniProtKB/Swiss-Prot:

BRAP_HUMAN :
  • Contains 1 RING-type zinc finger.
Similarity:
  • Contains 1 RING-type zinc finger.
  • Contains 1 UBP-type zinc finger.
genes like me logo Genes that share domains with BRAP: view

Function for BRAP Gene

Molecular function for BRAP Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.

Enzyme Numbers (IUBMB) for BRAP Gene

Gene Ontology (GO) - Molecular Function for BRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0004842 ubiquitin-protein transferase activity IDA 14724641
GO:0005515 protein binding IPI 9497340
GO:0008139 nuclear localization sequence binding IDA 9497340
genes like me logo Genes that share ontologies with BRAP: view
genes like me logo Genes that share phenotypes with BRAP: view

Animal Models for BRAP Gene

MGI Knock Outs for BRAP:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BRAP Gene

Localization for BRAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRAP Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BRAP Gene COMPARTMENTS Subcellular localization image for BRAP gene
Compartment Confidence
cytosol 5
nucleus 5
peroxisome 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for BRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 14724641
GO:0005737 cytoplasm IDA 9497340
GO:0005829 cytosol TAS --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with BRAP: view

Pathways & Interactions for BRAP Gene

SuperPathways for BRAP Gene

SuperPathway Contained pathways
1 RET signaling
2 Developmental Biology
3 Cytokine Signaling in Immune system
4 HIV Life Cycle
.45
5 Immune System
genes like me logo Genes that share pathways with BRAP: view

Pathways by source for BRAP Gene

UniProtKB/Swiss-Prot Q7Z569-BRAP_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for BRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0007265 Ras protein signal transduction IDA 14724641
GO:0009968 negative regulation of signal transduction IDA 14724641
GO:0016567 protein ubiquitination IEA,IDA --
genes like me logo Genes that share ontologies with BRAP: view

No data available for SIGNOR curated interactions for BRAP Gene

Transcripts for BRAP Gene

Unigene Clusters for BRAP Gene

BRCA1 associated protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BRAP Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2:

Relevant External Links for BRAP Gene

GeneLoc Exon Structure for
BRAP
ECgene alternative splicing isoforms for
BRAP

Expression for BRAP Gene

mRNA expression in normal human tissues for BRAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BRAP Gene

This gene is overexpressed in Testis (x4.2).

Protein differential expression in normal tissues from HIPED for BRAP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (26.0), Testis (25.8), and CD8 Tcells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for BRAP Gene



Protein tissue co-expression partners for BRAP Gene

NURSA nuclear receptor signaling pathways regulating expression of BRAP Gene:

BRAP

SOURCE GeneReport for Unigene cluster for BRAP Gene:

Hs.530940

mRNA Expression by UniProt/SwissProt for BRAP Gene:

Q7Z569-BRAP_HUMAN
Tissue specificity: Expressed in breast epithelial cell lines.
genes like me logo Genes that share expression patterns with BRAP: view

Primer Products

Orthologs for BRAP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BRAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BRAP 34 35
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia BRAP 34 35
  • 93.36 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia BRAP 35
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BRAP 34 35
  • 91.55 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 87 (a)
OneToMany
-- 35
  • 53 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Brap 34 16 35
  • 85.9 (n)
rat
(Rattus norvegicus)
Mammalia Brap 34
  • 84.88 (n)
chicken
(Gallus gallus)
Aves BRAP 34 35
  • 79.76 (n)
lizard
(Anolis carolinensis)
Reptilia BRAP 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia brap 34
  • 74.19 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68778 34
zebrafish
(Danio rerio)
Actinopterygii brap 34 35
  • 73.84 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5555 36 34 35
  • 53.23 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002128 34
  • 53.12 (n)
worm
(Caenorhabditis elegans)
Secernentea EEED8.16 36 34 35
  • 49.44 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ETP1 34 35 37
  • 50.71 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL079C 34
  • 49 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F25740g 34
  • 48.83 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons BRIZ2 34
  • 49.57 (n)
rice
(Oryza sativa)
Liliopsida Os02g0182900 34
  • 52.29 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU11215 34
  • 48.33 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC16E8.13 34
  • 48.22 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4818 35
  • 43 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10973 34
Species where no ortholog for BRAP was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BRAP Gene

ENSEMBL:
Gene Tree for BRAP (if available)
TreeFam:
Gene Tree for BRAP (if available)

Paralogs for BRAP Gene

(3) SIMAP similar genes for BRAP Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BRAP: view

No data available for Paralogs for BRAP Gene

Variants for BRAP Gene

Sequence variations from dbSNP and Humsavar for BRAP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10744773 -- 111,649,006(+) CAAAA(A/C)AACAA intron-variant
rs10744774 -- 111,652,218(+) CCCTA(A/C)AAAGG intron-variant
rs10744775 -- 111,658,411(+) TTCTC(C/T)GCTTC intron-variant
rs10774632 -- 111,648,699(+) AAAGC(A/G)GGTGG intron-variant
rs10774633 -- 111,658,485(+) CATGC(C/T)CAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BRAP Gene

Variant ID Type Subtype PubMed ID
esv3630761 CNV loss 21293372
esv3630762 CNV gain 21293372
esv3630763 CNV gain 21293372
nsv973119 CNV duplication 23825009

Variation tolerance for BRAP Gene

Residual Variation Intolerance Score: 20.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.58; 30.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BRAP Gene

Human Gene Mutation Database (HGMD)
BRAP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
BRAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BRAP Gene

Disorders for BRAP Gene

Relevant External Links for BRAP

Genetic Association Database (GAD)
BRAP
Human Genome Epidemiology (HuGE) Navigator
BRAP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BRAP

No disorders were found for BRAP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BRAP Gene

Publications for BRAP Gene

  1. SNPs in BRAP associated with risk of myocardial infarction in Asian populations. (PMID: 19198608) Ozaki K. … Tanaka T. (Nat. Genet. 2009) 2 3 46 64
  2. Identification of a novel cytoplasmic protein that specifically binds to nuclear localization signal motifs. (PMID: 9497340) Li S. … Lee W.-H. (J. Biol. Chem. 1998) 2 3 4 64
  3. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PMID: 20139978) Kamatani Y. … Kamatani N. (Nat. Genet. 2010) 3 46 64
  4. Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk. (PMID: 19698717) Cui R. … Matsuda K. (Gastroenterology 2009) 3 46 64
  5. Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP. (PMID: 14724641) Matheny S.A. … White M.A. (Nature 2004) 3 4 64

Products for BRAP Gene

Sources for BRAP Gene

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