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Aliases for BRAP Gene

Aliases for BRAP Gene

  • BRCA1 Associated Protein 2 3 5
  • Impedes Mitogenic Signal Propagation 2 3 4
  • Renal Carcinoma Antigen NY-REN-63 3 4
  • Galectin-2-Binding Protein 2 3
  • RING Finger Protein 52 3 4
  • BRAP2 3 4
  • RNF52 3 4
  • IMP 3 4
  • EC 6.3.2.- 4

External Ids for BRAP Gene

Previous GeneCards Identifiers for BRAP Gene

  • GC12M110940
  • GC12U900022
  • GC12M111864
  • GC12M110493
  • GC12M110544
  • GC12M112080
  • GC12M109093

Summaries for BRAP Gene

Entrez Gene Summary for BRAP Gene

  • The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq, Jul 2008]

GeneCards Summary for BRAP Gene

BRAP (BRCA1 Associated Protein) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include nucleotide binding and ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for BRAP Gene

  • Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BRAP Gene

Genomics for BRAP Gene

Regulatory Elements for BRAP Gene

Promoters for BRAP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BRAP on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the BRAP gene promoter:

Genomic Location for BRAP Gene

Chromosome:
12
Start:
111,642,146 bp from pter
End:
111,685,996 bp from pter
Size:
43,851 bases
Orientation:
Minus strand

Genomic View for BRAP Gene

Genes around BRAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BRAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BRAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BRAP Gene

Proteins for BRAP Gene

  • Protein details for BRAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z569-BRAP_HUMAN
    Recommended name:
    BRCA1-associated protein
    Protein Accession:
    Q7Z569
    Secondary Accessions:
    • B4DRM1
    • B9EGS8
    • O43238
    • O75341

    Protein attributes for BRAP Gene

    Size:
    592 amino acids
    Molecular mass:
    67305 Da
    Quaternary structure:
    • Interacts with the nuclear localization signal of BRCA1 and with the N-terminal of KSR1. The C-terminal portion of BCRA1 interacts with DDB1.
    SequenceCaution:
    • Sequence=AAC24200.1; Type=Frameshift; Positions=556; Evidence={ECO:0000305};

    Alternative splice isoforms for BRAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BRAP Gene

Proteomics data for BRAP Gene at MOPED

Post-translational modifications for BRAP Gene

  • Ubiquitination at Lys 385 and Lys 580
  • Modification sites at PhosphoSitePlus

Other Protein References for BRAP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for BRAP Gene

Domains & Families for BRAP Gene

Gene Families for BRAP Gene

Suggested Antigen Peptide Sequences for BRAP Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z569

UniProtKB/Swiss-Prot:

BRAP_HUMAN :
  • Contains 1 RING-type zinc finger.
Similarity:
  • Contains 1 RING-type zinc finger.
  • Contains 1 UBP-type zinc finger.
genes like me logo Genes that share domains with BRAP: view

Function for BRAP Gene

Molecular function for BRAP Gene

UniProtKB/Swiss-Prot Function:
Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.

Enzyme Numbers (IUBMB) for BRAP Gene

Gene Ontology (GO) - Molecular Function for BRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0016874 ligase activity IEA --
GO:0061630 ubiquitin protein ligase activity TAS --
genes like me logo Genes that share ontologies with BRAP: view
genes like me logo Genes that share phenotypes with BRAP: view

Animal Models for BRAP Gene

MGI Knock Outs for BRAP:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BRAP Gene

Localization for BRAP Gene

Subcellular locations from UniProtKB/Swiss-Prot for BRAP Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BRAP Gene COMPARTMENTS Subcellular localization image for BRAP gene
Compartment Confidence
cytosol 5
nucleus 5
peroxisome 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for BRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 9497340
genes like me logo Genes that share ontologies with BRAP: view

Pathways & Interactions for BRAP Gene

SuperPathways for BRAP Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 Signaling by GPCR
3 Immune System
4 Developmental Biology
5 Negative regulation of MAPK pathway
genes like me logo Genes that share pathways with BRAP: view

Pathways by source for BRAP Gene

UniProtKB/Swiss-Prot Q7Z569-BRAP_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for BRAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0008286 insulin receptor signaling pathway TAS --
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
GO:0009968 negative regulation of signal transduction IDA 14724641
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with BRAP: view

No data available for SIGNOR curated interactions for BRAP Gene

Drugs & Compounds for BRAP Gene

No Compound Related Data Available

Transcripts for BRAP Gene

Unigene Clusters for BRAP Gene

BRCA1 associated protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BRAP Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2:

Relevant External Links for BRAP Gene

GeneLoc Exon Structure for
BRAP
ECgene alternative splicing isoforms for
BRAP

Expression for BRAP Gene

mRNA expression in normal human tissues for BRAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BRAP Gene

This gene is overexpressed in Testis (x4.2).

Protein differential expression in normal tissues from HIPED for BRAP Gene

This gene is overexpressed in Peripheral blood mononuclear cells (26.0), Testis (25.8), and CD8 Tcells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BRAP Gene



SOURCE GeneReport for Unigene cluster for BRAP Gene Hs.530940

mRNA Expression by UniProt/SwissProt for BRAP Gene

Q7Z569-BRAP_HUMAN
Tissue specificity: Expressed in breast epithelial cell lines.
genes like me logo Genes that share expression patterns with BRAP: view

Protein tissue co-expression partners for BRAP Gene

Primer Products

In Situ Assay Products

Orthologs for BRAP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for BRAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BRAP 36
  • 100 (a)
OneToOne
BRAP 35
  • 99.66 (n)
  • 99.83 (a)
cow
(Bos Taurus)
Mammalia BRAP 35
  • 91.55 (n)
  • 96.45 (a)
BRAP 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BRAP 36
  • 97 (a)
OneToOne
BRAP 35
  • 93.36 (n)
  • 97.3 (a)
mouse
(Mus musculus)
Mammalia Brap 36
  • 91 (a)
OneToOne
Brap 35
  • 85.9 (n)
  • 91.03 (a)
Brap 16
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 87 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia BRAP 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Brap 35
  • 84.88 (n)
  • 90.69 (a)
chicken
(Gallus gallus)
Aves BRAP 35
  • 79.76 (n)
  • 88.18 (a)
BRAP 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BRAP 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68778 35
tropical clawed frog
(Silurana tropicalis)
Amphibia brap 35
  • 74.19 (n)
  • 83.25 (a)
zebrafish
(Danio rerio)
Actinopterygii brap 36
  • 79 (a)
OneToOne
brap 35
  • 73.84 (n)
  • 79.69 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002128 35
  • 53.12 (n)
  • 47.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5555 37
  • 44 (a)
CG5555 35
  • 53.23 (n)
  • 46.7 (a)
CG5555 36
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea EEED8.16 37
  • 36 (a)
EEED8.16 35
  • 49.44 (n)
  • 41.01 (a)
EEED8.16 36
  • 36 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL079C 35
  • 49 (n)
  • 40.53 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ETP1 35
  • 50.71 (n)
  • 43.11 (a)
ETP1 36
  • 29 (a)
OneToOne
ETP1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F25740g 35
  • 48.83 (n)
  • 40.47 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons BRIZ2 35
  • 49.57 (n)
  • 39.72 (a)
rice
(Oryza sativa)
Liliopsida Os02g0182900 35
  • 52.29 (n)
  • 48.19 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU11215 35
  • 48.33 (n)
  • 37.56 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC16E8.13 35
  • 48.22 (n)
  • 39.67 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10973 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4818 36
  • 43 (a)
OneToOne
Species with no ortholog for BRAP:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BRAP Gene

ENSEMBL:
Gene Tree for BRAP (if available)
TreeFam:
Gene Tree for BRAP (if available)

Paralogs for BRAP Gene

(3) SIMAP similar genes for BRAP Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BRAP: view

No data available for Paralogs for BRAP Gene

Variants for BRAP Gene

Sequence variations from dbSNP and Humsavar for BRAP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs646275 -- 111,682,366(-) TGCAC(A/G)CTACT intron-variant
rs1989938 -- 111,659,298(+) CTGAC(A/G)TACCG reference, synonymous-codon
rs2879592 -- 111,643,634(+) GTTTA(C/G)TACCA utr-variant-3-prime
rs2879593 -- 111,643,635(+) TTTAC(A/T)ACCAG utr-variant-3-prime
rs2879594 -- 111,643,636(+) TTACT(A/G)CCAGG utr-variant-3-prime

Variation tolerance for BRAP Gene

Residual Variation Intolerance Score: 20.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.58; 30.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BRAP Gene

HapMap Linkage Disequilibrium report
BRAP
Human Gene Mutation Database (HGMD)
BRAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for BRAP Gene

Disorders for BRAP Gene

Relevant External Links for BRAP

Genetic Association Database (GAD)
BRAP
Human Genome Epidemiology (HuGE) Navigator
BRAP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BRAP

No disorders were found for BRAP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BRAP Gene

Publications for BRAP Gene

  1. SNPs in BRAP associated with risk of myocardial infarction in Asian populations. (PMID: 19198608) Ozaki K. … Tanaka T. (Nat. Genet. 2009) 2 3 48 67
  2. Brap2 functions as a cytoplasmic retention protein for p21 during monocyte differentiation. (PMID: 15340083) Asada M. … Mizutani S. (Mol. Cell. Biol. 2004) 3 23
  3. Identification of a novel cytoplasmic protein that specifically binds to nuclear localization signal motifs. (PMID: 9497340) Li S. … Lee W.-H. (J. Biol. Chem. 1998) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Interactome of the negative regulator of nuclear import BRCA1-binding protein 2. (PMID: 25820252) Fatima S. … Jans D.A. (Sci. Rep. 2015) 3

Products for BRAP Gene

Sources for BRAP Gene

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