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BRAF Gene

protein-coding GIFtS: 75

GC07M140080

v-raf murine sarcoma viral oncogene homolog B1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
B-RAF1 ^²
B-Raf ^²
BRAF1 ^¹, ², ³
EC 2.7.11.1 ^³
FLJ95109 ^²
MGC126806 ^²
MGC138284 ^²
RAFB1 ^², ³
p94 ^³

Descriptions
94 kDa B-raf protein ^²
B-Raf proto-oncogene serine/threonine-protein kinase (p94) ^²
murine sarcoma viral (v-raf) oncogene homolog B1 ^²
v-raf murine sarcoma viral oncogene homolog B1 ^², ³

External Ids
HGNC: 1097¹
Entrez Gene: 673²
UniProtKB: P15056³
Ensembl: ENSG00000157764⁷

Search outside databases for aliases for BRAF gene

Previous GC identifers: GC07M138705 GC07M139764 GC07M139841 GC07M139754 GC07M139887

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for BRAF:

This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases.

This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell

division, differentiation, and secretion. Mutations in this gene are associated with

cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a

distinctive facial appearance. Mutations in this gene have also been associated with various

cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma,

non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on

chromosome X, has been identified for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: BRAF1_HUMAN, P15056

Function: Involved in the transduction of mitogenic signals from the cell membrane to the nucleus.

May play a role in the postsynaptic responses of hippocampal neuron

Gene Wiki entry for BRAF

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the BRAF gene

Entrez Gene cytogenetic band: 7q34 Ensembl cytogenetic band: 7q34 HGNC cytogenetic band: 7q34

BRAF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M140080: (about GC identifiers)

Start:	140,080,751 bp from pter
End:	140,271,033 bp from pter
Size:	190,283 bases
Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 139,772,459-139,962,886

RefSeq DNA sequence:

NC_000007.12 NT_007914.14 NT_079596.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: BRAF1_HUMAN, P15056 (See protein sequence)

Recommended Name: B-Raf proto-oncogene serine/threonine-protein kinase

Size: 766 amino acids; 84437 Da

Cofactor: Binds 2 zinc ions per subunit (By similarity)

Subunit: Interacts with RIT1 (By similarity)

Subcellular location: Cytoplasm

Sequence caution: Sequence=AAD43193.1; Type=Erroneous gene model prediction;

PDB structures from and Proteopedia :

1UWH (3D)

1UWJ (3D)

2FB8 (3D)

3C4C (3D)

3C4D (3D)

3D4Q (3D)

Secondary accessions: Q13878 Q3MIN6 Q9UDP8 Q9Y6T3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004324.2

ENSEMBL proteins:

ENSP00000288602

Human Recombinant Proteins

	Invitrogen human recombinant proteins for BRAF
	Millipore Purified and/or Recombinant BRAF Protein
	Sigma-Aldrich Proteins for BRAF
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (B Raf)
	Human Recombinant Proteins from Abnova (BRAF)

OriGene Purified Recombinant Human Protein: BRAF

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	18029348
GO:0005737	cytoplasm	IEA	--

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Antibodies for BRAF:

	Invitrogen Antibodies for BRAF
	Millipore Mono- and Polyclonal Antibodies for the study of BRAF
	Sigma-Aldrich Antibodies for BRAF
	R&D Systems Antibodies for BRAF (B-Raf)
	Cell Signaling Technology (CST) Antibodies for BRAF (B-Raf)
	Antibodies from Abcam (B Raf), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (BRAF)
	Novus Biologicals Antibodies for BRAF

Assays for BRAF:

	Invitrogen Assays for BRAF
	Millipore Kits and Assays for the Analysis of BRAF
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P15056

ProtoNet protein and cluster: P15056

2 Blocks protein families:

IPB002219 Protein kinase C

IPB003116 Raf-like Ras-binding

UniProtKB/Swiss-Prot: BRAF1_HUMAN, P15056

Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF

subfamily

Similarity: Contains 1 phorbol-ester/DAG-type zinc finger

Similarity: Contains 1 protein kinase domain

Similarity: Contains 1 RBD (Ras-binding) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BRAF)
		Millipore RNAi Products for the Analysis of BRAF Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (BRAF)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004333

Applied Biosystems Silencer® siRNAs for BRAF

Sigma-Aldrich siRNA and siRNA Panels for BRAF

Sigma-Aldrich shRNA Panels and shRNA for BRAF

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004333
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004333
untagged cDNA clone in CMV expression vector: NM_004333

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004333

UniProtKB/Swiss-Prot: BRAF1_HUMAN, P15056

Function: Involved in the transduction of mitogenic signals from the cell membrane to the nucleus.

May play a role in the postsynaptic responses of hippocampal neuron

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme Number (IUBMB): EC 2.7.11.1

Genatlas biochemistry entry for BRAF:

murine sarcoma 3611 viral (v-raf) oncogene homolog B1 (Rmil),expressed in cerebrum and testis,fused

with TIF1A to form the oncoprotein T18

15/20 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Braf) (see all 20 ):

	behavior/neurological	cellular	craniofacial	embryogenesis
endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism	immune system
lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging	liver/biliary system	nervous system

5/9 Gene Ontology (GO) molecular function terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004674	protein serine/threonine kinase activity	IEA	--
GO:0005057	receptor signaling protein activity	IEA	--
GO:0005515	protein binding	IPI	17353931
GO:0005524	ATP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/16 Sigma-Aldrich "Your Favorite Gene" Pathways for BRAF (Your Favorite Gene powered by Ingenuity) (see all 16 )

Integrin Signaling
G-Protein Coupled Receptor Signaling
Endothelin-1 Signaling
Thyroid Cancer Signaling
Acute Myeloid Leukemia Signaling

GeneDecks BRAF for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for BRAF

5/93 Interacting proteins for BRAF (ENSP00000288602³ P15056^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 93 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRKCA	P17252²	STRING (score=.952) MINT-2833162
YWHAZ	P63104¹^,²	STRING (score=.801) EBI-365980, EBI-347088 MINT-3295552 MINT-51024 EBI-365980, EBI-347088 MINT-3295552 MINT-51024
YWHAB	P31946¹^,²	STRING (score=.99) EBI-365980, EBI-359815 MINT-50344 EBI-365980, EBI-359815 MINT-50344
YWHAQ	P27348¹^,²	STRING (score=.752) EBI-365980, EBI-359854 MINT-50372 EBI-365980, EBI-359854 MINT-50372
YWHAG	P61981¹^,²	EBI-365980, EBI-359832 MINT-50888 EBI-365980, EBI-359832 MINT-50888

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein amino acid phosphorylation	TAS	2284096
GO:0006916	anti-apoptosis	TAS	9207797
GO:0007264	small GTPase mediated signal transduction	EXP	10712923
GO:0009887	organ morphogenesis	TAS	9207797

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for BRAF available from Tocris Bioscience

Compound	Action	CAS number
ZM 336372	Potent, selective c-Raf inhibitor	[208260-29-1]
GW 5074	Potent, selective c-Raf1 kinase inhibitor	[220904-83-6]
L-779,450	Potent Raf kinase inhibitor	[303727-31-3]

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10/32 Novoseek chemical compound relationships for BRAF gene (see all 32 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
crcs	76.28	18	19147861 (2), 18435933 (2), 15542810 (2), 14639609 (1) (see all 12)
gw-5074	63.91	11	18194435 (5), 16314406 (1), 15255937 (1)
17-(allylamino)-17-demethoxygeldanamycin	62.63	10	18375819 (2), 16371460 (1), 18281615 (1), 18676857 (1)
threonine	61.53	37	8557035 (1), 14508525 (1), 19206169 (1), 1630826 (1) (see all 31)
o6-methylguanine	52.14	5	17867575 (1), 18300810 (1), 15616773 (1), 16118624 (1) (see all 5)
phosphatidylinositol	41.15	6	15263001 (2), 8576262 (1), 17183069 (1), 19118027 (1) (see all 5)
tyrosine	40.80	24	10205168 (2), 9020159 (2), 12446733 (2), 9844921 (1) (see all 16)
sodium iodide	40.02	1	16254036 (1)
pd 98,059	31.91	6	17709622 (3), 18194435 (1), 17424890 (1), 15705790 (1) (see all 6)
thymine	30.84	10	15968271 (1), 15641040 (1), 16708643 (1), 15126572 (1) (see all 8)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (BRAF)
		Millipore RNAi Products for the Analysis of BRAF Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (BRAF)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004333

Sigma-Aldrich siRNA and siRNA Panels for BRAF

Sigma-Aldrich shRNA Panels and shRNA for BRAF

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004333

REFSEQ mRNAs for BRAF gene:

NM_004333.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004333

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004333
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004333
                                 untagged cDNA clone in CMV expression vector: NM_004333

Additional cDNA sequence:

AK314346.1 BC038966.1 BC101757.1 BC112079.1 M21001.1 M95712.2

8 DOTS entries:

DT.412400 DT.95121279 DT.92070713 DT.121078775 DT.75172532 DT.121078703 DT.40105916 DT.445289

24/151 AceView cDNA sequences (see all 151 ):

CA396753 BF089752 BQ771705 BM684937 BE620440 AI040223 BX280711 AL135067

AA812678 AK098095 AA705424 AI384098 AI635384 AA279937 BM931879 AA907838

AI378370 BU742293 AI435611 AU118767 CB241287 AA679780 AA905230 AW613053

highest scoring ESTs for BRAF:

M95712 AA741481 AI018295 AI203435 AL039290 AW295124 AA252274 AA262800 AA805671 AA815165

Unigene Cluster for BRAF:

V-raf murine sarcoma viral oncogene homolog B1

Hs.550061 [show with all ESTs]

Unigene Representative Sequence: NM_004333

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000288602

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

BRAF expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for BRAF

¹ / ² / ³

7 probe-sets matching BRAF gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1654_at²^{, 3}	U95-A	2	1.00	0.72	-0.17	1.03	M95712	1.00	1.00	1.00	1
40306_at²^{, 3}	U95-A	2	1.00	0.59	0.10	0.62	M95712	1.00	1.00	1.00	1
86199_r_at²^{, 3}	U95-D	1	0.69	1.00	1.00	1.00	R17104	0.60	1.00	0.82	1
243829_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW613053	0.60	1.00	0.82	1
206044_s_at²^{, 3}	U133-A	2	1.00	0.73	--	--	NM_004333	0.60	1.00	0.82	1
243829_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206044_s_at²	U133Plus2	2	1.00	0.73	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAGAGATTAA

SOURCE GeneReport for Unigene cluster: Hs.550061
Expression variation in blood from EXPOLDB for BRAF
UniProtKB/Swiss-Prot: BRAF1_HUMAN, P15056
Tissue specificity: Brain and testis

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for BRAF gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	BRAF¹	--	v-raf murine sarcoma viral oncogene homolog B1	94.9(n) 98.75(a)	475526 XM_532749.2 XP_532749.2
chimpanzee (Pan troglodytes)	BRAF¹	--	v-raf murine sarcoma viral oncogene homolog B1	99.78(n) 99.87(a)	463781 XM_001155024.1 XP_001155024.1
cow (Bos taurus)	BRAF¹	--	v-raf murine sarcoma viral oncogene homolog B1	95.43(n) 98.54(a)	536051 XM_864068.2 XP_869161.2
rat (Rattus norvegicus)	Braf¹	--	v-raf murine sarcoma viral oncogene homolog B1	92.52(n) 98.2(a)	114486 XM_231692.4 XP_231692.4
mouse (Mus musculus)	Braf^{1, 5}	6 (15.50 cM)⁵	Braf transforming gene^{1, 5}	93.03(n)¹ 98.06(a)¹	109880¹ NM_139294.4¹ NP_647455.2¹ AA120551⁵ AA386732⁵ (see all 43)

About this table Species with no ortholog for BRAF

ENSEMBL Gene Tree for BRAF

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for BRAF gene

ARAF² RAF1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/854 NCBI SNPs in BRAF are shown (see all 854 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 173)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs6464149^1,2	A,C	140272305(+)	`TACTGA/CCTTCT`	1	--	ng3¹		0	--	--	--	--
	rs34776339^1,2	C	140146710(+)	`CTGTGG/ATATTG`	1	S/P	mis¹		4		EU EA WA	420
--	rs9648696^1,2	A,C,F	140095619(+)	`ACAATT/CCCAAA`	1	G/G	syn¹		1		NA	62
--	rs1042179^1,2	C,F	140095619(-)	`TTTGGA/GATTGT`	1	G/G	syn¹		0	--	--	--	--
--	rs2228520^1,2	F	140146696(-)	`GAGGCG/ATCCTT`	1	A/A	syn¹		8		MN NA EU EA WA	626
--	rs1267618^1,2	A,C,F,H,O	140206487(+)	`CAGAAC/TGGACT`	1	--	int¹		5		MN EU EA WA	602
	rs1267621^1,2	A,C,F,H,O	140202636(+)	`AACCAC/TTTAGT`	1	--	int¹		12		MN NA EU EA WA	1106
	rs1267612^1,2	A,C,F,H,O	140158229(+)	`CATTCG/ATCTTC`	1	--	int¹		15		EU EA WA NA	1388
	rs1267648^1,2	A,C,F,H,O	140151569(+)	`AAATGT/CCTATT`	1	--	int¹		11		NA EU EA WA	960
	rs1267622^1,2	A,C,F,H,O	140174786(+)	`ATGTGA/GTATAC`	1	--	int¹		17		NS EU EA WA NA	1160

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HapMap Linkage Disequilibrium images for BRAF (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 164757

UniProtKB/Swiss-Prot: BRAF1_HUMAN, P15056

Defects in BRAF are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150];

also known as cardio-facio-cutaneous syndrome. CFC syndrome is characterized by a distinctive

facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis,

atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with

ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a

generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome.

They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges,

downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with

prominent helices. The inheritance of CFC syndrome is autosomal dominant

Defects in BRAF are involved in a wide range of cancers

Defects in BRAF are involved in lung cancer [MIM:211980]

Defects in BRAF are involved in non-Hodgkin lymphoma (NHL) [MIM:605027]. NHL is a cancer

that starts in cells of the lymph system, which is part of the body's immune system. NHLs can

occur at any age and are often marked by enlarged lymph nodes, fever and weight loss

Defects in BRAF may be a cause of colorectal cancer (CRC) [MIM:114500]

10/96 Novoseek disease relationships for BRAF gene (see all 96 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
thyroid papillary carcinoma	90.60	135	15968271 (6), 17060774 (4), 15095090 (2), 16452550 (2) (see all 96)
cfc syndrome	89.44	14	18651097 (2), 17366577 (2), 17551924 (2), 19206169 (1) (see all 10)
microsatellite instability	87.39	79	16403224 (4), 18718023 (3), 15221372 (2), 18517279 (2) (see all 64)
papillary thyroid cancer	86.23	49	16487015 (3), 16174717 (2), 12970315 (2), 16708643 (2) (see all 34)
melanoma	84.94	739	15824163 (9), 15917418 (8), 17699719 (8), 15060100 (7) (see all 99)
somatic mutations	80.22	50	16567964 (2), 14688025 (2), 14612909 (1), 15093535 (1) (see all 43)
thyroid carcinoma anaplastic	78.75	18	15195111 (7), 16533790 (2), 15880523 (1), 17878251 (1) (see all 9)
thyroid cancer	77.38	53	17878251 (5), 12970315 (3), 17179987 (3), 17911174 (2) (see all 31)
colorectal cancer	75.39	163	14734469 (7), 17924122 (6), 15782118 (5), 15340260 (5) (see all 77)
nevi	73.35	108	16799476 (6), 15009715 (5), 15824163 (4), 15330192 (4) (see all 38)

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1 PharmGKB disease relationship for BRAF gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Nevi and Melanomas	FA	15694309

About this table

GeneTests: BRAF

Cardiofaciocutaneous Syndrome

Human Gene Mutation Database: BRAF
Genetic Association Database: BRAF
Human Genome Epidemiology Navigator: BRAF (108 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1036 PubMed articles for BRAF gene (see all 1036 ):

Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies. (PubMed id 2284096)^{2, 3, 4} Sithanandam G.... Rapp U.R. (1990)
BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer. (PubMed id 16174717)^{1, 3, 6} Xing M....Ladenson P.W. (2005)
BRAF mutations in non-Hodgkin's lymphoma. (PubMed id 14612909)^{1, 3, 4} Lee J.W.... Lee S.H. (2003)
No Evidence for BRAF as a melanoma/nevus susceptibility gene. (PubMed id 15824163)^{1, 3, 6} Jackson S....Newton Bishop J.A. (2005)
BRAF gene is somatically mutated but does not make a major contribution to malignant melanoma susceptibility: the Italian Melanoma Intergroup Study. (PubMed id 14722037)^{1, 3, 6} Casula M....Palmieri G. (2004)
BRAF mutation in endometrial carcinoma and hyperplasia: correlation with KRAS and p53 mutations and mismatch repair protein expression. (PubMed id 16144912)^{1, 3, 6} Feng Y.Z....Konishi I. (2005)
Mutations of the BRAF gene in papillary thyroid carcinoma and in Hashimoto's thyroiditis. (PubMed id 16143028)^{1, 3, 6} Kim K.H....Kang D.Y. (2005)
BRAF polymorphisms and risk of melanocytic neoplasia. (PubMed id 16354196)^{1, 3, 6} James M.R....Duffy D.L. (2005)
BRAF and NRAS mutations are frequent in nodular melanoma but are not associated with tumor cell proliferation or patient survival. (PubMed id 16098042)^{1, 3, 6} Akslen L.A....Kumar R. (2005)
Uncommon V599E BRAF mutations in Japanese patients with lung cancer. (PubMed id 16376942)^{1, 3, 6} Sasaki H....Fujii Y. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 673	HGNC: 1097	AceView: BRAF	Ensembl:ENSG00000157764	euGenes: HUgn673
ECgene: BRAF	H-InvDB: BRAF

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for BRAF	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=BRAF

Licensable Technologies for BRAF
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for BRAF:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for BRAF-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for BRAF		Antibodies for BRAF
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (BRAF)
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Antibodies & Assays for BRAF (B-Raf)

	Recombinant Proteins (B Raf)
	Antibodies (B Raf)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for BRAF

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for BRAF

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BRAF Gene

protein-coding GIFtS: 75

Aliases &
Descriptions
for BRAF

Summaries
for BRAF

Genomic Location
for BRAF

Proteins
for BRAF

Protein Domains/
Families
for BRAF

Gene Function
for BRAF

Pathways & Interactions
for BRAF

Drugs & Compounds
for BRAF

Transcripts
for BRAF

Expression
for BRAF

Orthologs
for BRAF

Paralogs
for BRAF

SNPs/Variants
for BRAF

Disorders & Mutations
for BRAF

Medical News
for BRAF

Publications
for BRAF

Search for BRAF

Genome Databases showing BRAF

Other Databases showing BRAF

Specialized Databases showing BRAF

Licensable Technologies
for BRAF

Services
for BRAF

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

BRAF Gene

protein-coding GIFtS: 75

Aliases & Descriptionsfor BRAF

Summariesfor BRAF

Genomic Locationfor BRAF

Proteinsfor BRAF

Protein Domains/Familiesfor BRAF

Gene Functionfor BRAF

Pathways & Interactionsfor BRAF

Drugs & Compoundsfor BRAF

Transcriptsfor BRAF

Expression for BRAF

Orthologsfor BRAF

Paralogsfor BRAF

SNPs/Variantsfor BRAF

Disorders & Mutationsfor BRAF

Medical Newsfor BRAF

Publicationsfor BRAF

Search for BRAF

Genome Databases showing BRAF

Other Databases showing BRAF

Specialized Databases showing BRAF

Licensable Technologiesfor BRAF

Servicesfor BRAF

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for BRAF

Summaries
for BRAF

Genomic Location
for BRAF

Proteins
for BRAF

Protein Domains/
Families
for BRAF

Gene Function
for BRAF

Pathways & Interactions
for BRAF

Drugs & Compounds
for BRAF

Transcripts
for BRAF

Expression
for BRAF

Orthologs
for BRAF

Paralogs
for BRAF

SNPs/Variants
for BRAF

Disorders & Mutations
for BRAF

Medical News
for BRAF

Publications
for BRAF

Licensable Technologies
for BRAF

Services
for BRAF