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BRAF Gene

protein-coding   GIFtS: 75
GCID: GC07M140424

V-Raf Murine Sarcoma Viral Oncogene Homolog B

(Previous name: v-raf murine sarcoma viral oncogene homolog B1)
  See BRAF-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
V-Raf Murine Sarcoma Viral Oncogene Homolog B1 2     B-RAF12
V-Raf Murine Sarcoma Viral Oncogene Homolog B11 2 3     B-Raf Proto-Oncogene Serine/Threonine-Protein Kinase (P94)2
Proto-Oncogene B-Raf2 3     Murine Sarcoma Viral (V-Raf) Oncogene Homolog B12
BRAF12 3     Serine/Threonine-Protein Kinase B-Raf2
RAFB12 3     EC 2.7.11.13
NS72 5     p943
94 KDa B-Raf Protein2     

External Ids:    HGNC: 10971   Entrez Gene: 6732   Ensembl: ENSG000001577647   OMIM: 1647575   UniProtKB: P150563   

Export aliases for BRAF gene to outside databases

Previous GC identifers: GC07M138705 GC07M139764 GC07M139841 GC07M139754 GC07M139887 GC07M140080 GC07M134729


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BRAF Gene:
This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein
plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation,
and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized
by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been
associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid
carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on
chromosome X, has been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for BRAF Gene:
BRAF (v-raf murine sarcoma viral oncogene homolog B) is a protein-coding gene. Diseases associated with BRAF include hairy cell leukemia, and noonan syndrome 7. GO annotations related to this gene include protein serine/threonine kinase activity and calcium ion binding. An important paralog of this gene is FPGT-TNNI3K.

UniProtKB/Swiss-Prot: BRAF_HUMAN, P15056
Function: Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus.
May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby
contributes to the MAP kinase signal transduction pathway

summary for BRAF Gene:
Raf kinases, a family of three serine/threonine kinases, are part of the ras-MAPK signaling cascade and
phosphorylate MEK. Upon growth factor stimulation, Raf-1 (or c-Raf) is activated by GTP-bound Ras and
recruited to the cell membrane. This activation process is tightly regulated by a number of factors
including phosphatases (e.g. PP1, PP2A, PP5), kinases (e.g. Src, ERK, Akt, PKC) and proteins that bind
directly to Raf-1 (e.g. RKIP, 14-3-3zeta, KSR, Hsp90). Raf-1 is also thought to be able to dimerize with
wild type B-Raf in a Ras-dependent process. B-raf is commonly mutated and thereby activated in many human
cancers, the most frequent mutation being the V600E mutation of the kinase domain. Whilst wt b-Raf and Raf-1
are strongly activated by growth factor signals via Ras and Src, a-Raf is only modestly activated and has
low basal activity. All three isoforms of Raf are considered to be oncogenic.

Gene Wiki entry for BRAF Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BRAF gene promoter:
         p53   AP-1   ATF-2   E2F-2   C/EBPalpha   E2F   E2F-1   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): BRAF promoter sequence
   Search Chromatin IP Primers for BRAF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BRAF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q34   Ensembl cytogenetic band:  7q34   HGNC cytogenetic band: 7q34

BRAF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BRAF gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M140424:  view genomic region     (about GC identifiers)

Start:
140,419,127 bp from pter      End:
140,624,564 bp from pter
Size:
205,438 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 139,771,989-139,962,886     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: BRAF_HUMAN, P15056 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase B-raf  
Size: 766 amino acids; 84437 Da
Cofactor: Binds 2 zinc ions per subunit (By similarity)
Subunit: Monomer. Homodimer. Heterodimerizes with RAF1, and the heterodimer possesses a highly increased kinase
activity compared to the respective homodimers or monomers. Heterodimerization is mitogen-regulated and enhanced
by 14-3-3 proteins. MAPK1/ERK2 activation can induce a negative feedback that promotes the dissociation of the
heterodimer by phosphorylating BRAF at Thr-753. Found in a complex with at least BRAF, HRAS, MAP2K1, MAPK3 and
RGS14. Interacts with RIT1. Interacts (via N-terminus) with RGS14 (via RBD domains); the interaction mediates the
formation of a ternary complex with RAF1, a ternary complex inhibited by GNAI1 (By similarity). Interacts with
DGKH. Interacts with PRMT5. Interacts with KSR2
Sequence caution: Sequence=AAD43193.1; Type=Erroneous gene model prediction; Sequence=CAQ43111.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened; Sequence=CAQ43112.1; Type=Erroneous initiation;
Note=Translation N-terminally shortened; Sequence=CAQ43113.1; Type=Erroneous initiation; Note=Translation
N-terminally shortened; Sequence=CAQ43114.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAQ43115.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAQ43116.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened;
Selected PDB 3D structures from and Proteopedia for BRAF (see all 35):
1UWH (3D)        1UWJ (3D)        2FB8 (3D)        2L05 (3D)        3C4C (3D)        3D4Q (3D)    
Secondary accessions: A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8
Q9Y6T3

Explore the universe of human proteins at neXtProt for BRAF: NX_P15056

Explore proteomics data for BRAF at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-365 by SGK1 inhibits its activity1
  • Methylation at Arg-671 decreases stability and kinase activity1
  • Ubiquitinated by RNF149; which leads to proteasomal degradation. Polyubiquitinated at Lys-578 in response to EGF1
  • Ubiquitination2 at Lys578
  • Modification sites at PhosphoSitePlus

  • See BRAF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004324.2  
    ENSEMBL proteins: 
     ENSP00000419060   ENSP00000288602   ENSP00000418033   ENSP00000420119  
    Reactome Protein details: P15056

    BRAF Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant BRAF Protein
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    Novus Biologicals BRAF Proteins
    Novus Biologicals BRAF Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for BRAF

     
    Search eBioscience for Proteins for BRAF 

     
    antibodies-online proteins for BRAF (3 products) 

     
    antibodies-online peptides for BRAF

    BRAF Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of BRAF
    R&D Systems Antibodies for BRAF (B-Raf)
    Cell Signaling Technology (CST) Antibodies for BRAF 
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    Abcam antibodies for BRAF
    Cloud-Clone Corp. Antibodies for BRAF
    ThermoFisher Antibody for BRAF
    antibodies-online antibodies for BRAF (238 products) 

    BRAF Assay Products:

    EMD Millipore Kits and Assays for the Analysis of BRAF
    OriGene Custom Assay Services for BRAF
    Browse R&D Systems for biochemical assays
    GenScript BRAF-Activity-based Kinase Assay for Compound Screening
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for BRAF
    Cloud-Clone Corp. CLIAs for BRAF
    Search eBioscience for ELISAs for BRAF 
    antibodies-online kits for BRAF (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: v-raf murine sarcoma viral oncogene homolog B1
    RAF family

    Selected InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR020454 DAG/PE-bd
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry P15056

    ProtoNet protein and cluster: P15056

    2 Blocks protein domains:
    IPB002219 Protein kinase C
    IPB003116 Raf-like Ras-binding


    UniProtKB/Swiss-Prot: BRAF_HUMAN, P15056
    Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 RBD (Ras-binding) domain


    Find genes that share domains with BRAF           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BRAF_HUMAN, P15056
    Function: Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus.
    May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby
    contributes to the MAP kinase signal transduction pathway
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activity is increased by EGF and HGF

         Genatlas biochemistry entry for BRAF:
    murine sarcoma 3611 viral (v-raf) oncogene homolog B1 (Rmil),expressed in cerebrum and testis,fused with TIF1A to
    form the oncoprotein T18

         Enzyme Number (IUBMB): EC 2.7.11.11

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA17563371
    GO:0004674protein serine/threonine kinase activity IDA19667065
    GO:0004709MAP kinase kinase kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005057receptor signaling protein activity ----
         
    Find genes that share ontologies with BRAF           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for BRAF:
     Decreased substrate adherent c  Synthetic lethal with Ras  Synthetic lethal with c-Myc af  Upregulation of Wnt/beta-caten 

         Selected MGI mutant phenotypes (inferred from 18 alleles(MGI details for Braf) (see all 25):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 

    Find genes that share phenotypes with BRAF           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for BRAF: Braftm1.1Wds Braftm1.1Sva Braftm1Zim

       genOway: Develop your customized and physiologically relevant rodent model for BRAF

    miRNA
    Products:
        
    miRTarBase miRNAs that target BRAF:
    hsa-mir-744-5p (MIRT037574), hsa-mir-191-5p (MIRT045803), hsa-mir-378a-5p (MIRT043975)

    Block miRNA regulation of human, mouse, rat BRAF using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate BRAF:
    hsa-miR-9 hsa-miR-659
    SwitchGear 3'UTR luciferase reporter plasmidBRAF 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for BRAF
    Predesigned siRNA for gene silencing in human, mouse, rat BRAF

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for BRAF

    Clone
    Products:
         
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    OriGene ORF clones in mouse, rat for BRAF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: BRAF (NM_004333)
    Sino Biological Human cDNA Clone for BRAF
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for BRAF
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    Addgene plasmids for BRAF 

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRAF

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-11135 VA4-12641) for BRAF 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    BRAF_HUMAN, P15056: Nucleus (By similarity). Cytoplasm. Cell membrane (By similarity). Note=Colocalizes with
    RGS14 and RAF1 in both the cytoplasm and membranes (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    plasma membrane4
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----

    Find genes that share ontologies with BRAF           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BRAF About   (see all 86)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1IL-9 Signaling Pathways
    IL-9 Signaling Pathways0.90
    IL-15 Signaling Pathways0.88
    IL-7 Signaling Pathways0.90
    IL-4 Signaling Pathways0.84
    IL-21 Signaling Pathways0.90
    Development Thrombopoietin regulated cell processes0.38
    Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    Adipocytokines and Insulin Signaling0.34
    2Glioma
    Glioma0.51
    Prostate cancer0.39
    Non-small cell lung cancer0.51
    Signaling Pathways in Glioblastoma0.36
    Melanoma0.43
    Bladder cancer0.31
    3Post NMDA receptor activation events
    Post NMDA receptor activation events0.90
    CREB phosphorylation through the activation of Ras0.78
    Activation of NMDA receptor upon glutamate binding and postsynaptic events0.90
    Long-term potentiation0.35
    4Focal adhesion
    Focal adhesion0.65
    Integrin-mediated cell adhesion0.38
    Focal Adhesion0.65
    5Sorafenib Pharmacodynamics
    Sorafenib Pharmacodynamics0.37
    VEGF Pathway0.36
    Vemurafenib Pathway, Pharmacodynamics0.37


    Find genes that share SuperPaths with BRAF           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for BRAF (see all 10)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-4 Signaling Pathways
    Adipocytokines & Insulin Signaling
    IL-7 Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for BRAF (see all 59)
        FLT3 Signaling
    IL-4 Pathway
    Molecular Mechanisms of Cancer
    eIF2 Pathway
    TRKA Signaling

    1 Cell Signaling Technology (CST) Pathway for BRAF
        MAP Kinase Signaling

    3 Tocris Bioscience Pathways for BRAF
        Insulin Pathway
    VEGF Pathway
    MAPK Pathway

    Selected GeneGo (Thomson Reuters) Pathways for BRAF (see all 17)
        G-protein signaling G-Protein alpha-s signaling cascades
    G-protein signaling M-RAS regulation pathway
    Development A2A receptor signaling
    Development Neurotrophin family signaling
    Development Thrombopoietin-regulated cell processes

    Selected BioSystems Pathways for BRAF (see all 20)
        MAPK signaling pathway
    Focal Adhesion
    Integrin-mediated cell adhesion
    Senescence and Autophagy
    Estrogen signaling pathway


    5 Reactome Pathways for BRAF
        Frs2-mediated activation
    ARMS-mediated activation
    CREB phosphorylation through the activation of Ras
    Signalling to p38 via RIT and RIN
    Spry regulation of FGF signaling

    2 PharmGKB Pathways for BRAF
        Sorafenib Pharmacodynamics
    Vemurafenib Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for BRAF) (see all 32):
        MAPK signaling pathway
    ErbB signaling pathway
    Rap1 signaling pathway
    Chemokine signaling pathway
    FoxO signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BRAF (see all 7): 
              Lung Cancer in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              Focal Adhesions in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for BRAF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for BRAF (P150561, 2, 3 ENSP000002886024) via UniProtKB, MINT, STRING, and/or I2D (see all 198)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000237724P081073, ENSP000004063594I2D: score=2 STRING: ENSP00000406359
    ENSG00000212866P081073I2D: score=2 
    ENSG00000215328P081073I2D: score=2 
    ENSG00000224501P081073I2D: score=2 
    ENSG00000231555P081073I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade ----
    GO:0000186activation of MAPKK activity TAS--
    GO:0006468protein phosphorylation IDA17563371
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction TAS--

    Find genes that share ontologies with BRAF           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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       Browse drugs & compounds from Enzo Life Sciences
    Selected ApexBio Compounds for BRAF (see all 13)     About this table
    CompoundAction CAS #
    AZ 628selective RAF inhibitor[878739-06-1]
    B-Raf inhibitoruseful in the treatment of cancer and proliferative diseases[1315330-11-0]
    BRAF inhibitora potent BRAF inhibitor[918505-61-0]
    CEP-32496Potent BRAF inhibitor[1188910-76-0]
    Dabrafenib Mesylate (GSK-2118436)selective BRAFV600E inhibitor[1195768-06-9]
    GDC-0879Potent and selective B-Raf inhibitor[905281-76-7]
    PF-04880594RAF inhibitor for BRAF/BRAFV599E and c-RAF[1111636-35-1]
    PLX-4720Potent and selective inhibitor of BRAF with V600E mutation[918505-84-7]
    RAF265Potent and selective Raf inhibitor, also inhibits VEGFR[927880-90-8]
    SorafenibMulti-target kinase inhibitor of Raf kinases and tyrosine kinases[284461-73-0]

    Compounds for BRAF available from Tocris Bioscience    About this table
    CompoundAction CAS #
    GDC 0879Potent B-Raf inhibitor[905281-76-7]
    ZM 336372 Potent, selective c-Raf inhibitor [208260-29-1]
    GW 5074 Potent, selective c-Raf1 kinase inhibitor [220904-83-6]
    SB 590885Potent B-Raf inhibitor[405554-55-4]
    L-779,450 Potent Raf kinase inhibitor[303727-31-3]

    Selected HMDB Compounds for BRAF (see all 845)    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----

    7 DrugBank Compounds for BRAF    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Sorafenib-- 284461-73-0targetinhibitor16901402 16880785 11752352 17575107 16609060 20812347
    (1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime-- --target--10592235
    Dabrafenib-- --targetinhibitor23621583
    N-{2,4-difluoro-3-[(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]phenyl}ethanesulfonamide-- --target--10592235
    N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide-- --target--10592235
    VemurafenibBRAF(V600E) Kinase Inhibitor RO5185426 (see all 4)918504-65-1targetinhibitor23094782
    Regorafenib-- 755037-03-7targetinhibitor--

    Selected Novoseek inferred chemical compound relationships for BRAF gene (see all 58)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    crcs 79.1 24 19474002 (4), 19147861 (2), 18435933 (2), 15542810 (2) (see all 15)
    panitumumab 77.9 3 19001320 (4), 19806185 (2), 18621636 (2), 19935791 (1)
    cetuximab 71.4 23 19001320 (4), 20146801 (3), 19806185 (2), 19884556 (2) (see all 13)
    sorafenib 71.2 33 19638574 (5), 18676765 (3), 19878585 (3), 18192256 (1) (see all 20)
    threonine 60.8 41 8557035 (1), 14508525 (1), 19206169 (1), 1630826 (1) (see all 35)
    gw-5074 59.5 11 18194435 (5), 16314406 (1), 15255937 (1)
    17-(allylamino)-17-demethoxygeldanamycin 58.8 10 18375819 (2), 16371460 (1), 18281615 (1), 18676857 (1)
    o6-methylguanine 51.4 6 19164452 (1), 17867575 (1), 18300810 (1), 15616773 (1) (see all 6)
    valine 47.7 10 15688405 (1), 16964379 (1), 19149686 (1), 19200582 (1) (see all 9)
    phosphatidylinositol 46.1 6 15263001 (2), 8576262 (1), 17183069 (1), 19118027 (1) (see all 5)

    3 PharmGKB related drug/compound annotations for BRAF gene    About this table
    Drug/compound PharmGKB Annotation
    dabrafenib
    trametinib
    vemurafenib



    Find genes that share compounds with BRAF           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BRAF gene: 
    NM_004333.4  

    Unigene Cluster for BRAF:

    V-raf murine sarcoma viral oncogene homolog B1
    Hs.550061  [show with all ESTs]
    Unigene Representative Sequence: NM_004333
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000496384 ENST00000288602(uc003vwc.4) ENST00000479537 ENST00000497784
    ENST00000469930
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat BRAF using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate BRAF:
    hsa-miR-9 hsa-miR-659
    SwitchGear 3'UTR luciferase reporter plasmidBRAF 3' UTR sequence
    Inhib. RNA
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    eBioscience FlowRNA Probe Sets ( VA1-11135 VA4-12641) for BRAF 

    Additional mRNA sequence: 

    AK314346.1 BC038966.1 BC101757.1 BC112079.1 GU149303.1 HM053972.1 HM437233.1 M21001.1 
    M95712.2 

    8 DOTS entries:

    DT.412400  DT.95121279  DT.92070713  DT.121078775  DT.75172532  DT.121078703  DT.40105916  DT.445289 

    Selected AceView cDNA sequences (see all 151):

    AI378370 BQ771705 BE620440 AI040223 AA676397 AK098095 AW613053 BU742293 
    CA868313 BM684937 AA705424 AA676542 AA679780 BM931879 AU118767 CA396753 
    CB241287 AA812678 AI435611 AA907838 AA905230 AA279936 AA279937 BF089752 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BRAF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAGATTAA
    BRAF Expression
    About this image


    BRAF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    BRAF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BRAF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.550061

    UniProtKB/Swiss-Prot: BRAF_HUMAN, P15056
    Tissue specificity: Brain and testis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including BRAF (see all 7): 
              Lung Cancer in human mouse rat
              Insulin Signaling Pathway in human mouse rat
              EGF / PDGF Signaling Pathway in human mouse rat
              Focal Adhesions in human mouse rat
              Apoptosis 384HT in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BRAF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BRAF gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Braf1 , 5 Braf transforming gene1, 5 92.6(n)1
    97.07(a)1
      6 (18.43 cM)5
    1098801  NM_139294.51  NP_647455.31 
     396032375 
    chicken
    (Gallus gallus)
    Aves BRAF1 v-raf murine sarcoma viral oncogene homolog B1 85.58(n)
    94.63(a)
      396239  NM_205302.1  NP_990633.1 
    lizard
    (Anolis carolinensis)
    Reptilia BRAF6
    v-raf murine sarcoma viral oncogene homolog B
    84(a)
    1 ↔ 1
    5(15598353-15659736)
    African clawed frog
    (Xenopus laevis)
    Amphibia BRAF2 serine/threonine protein kinase BRAF 79.22(n)    AB113401.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AB113402.12   -- 76.52(n)    AB113402.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta phl1 , 3 dorsal/ventral axis determination,
    follicular more3
    pole hole1
    42(a)3
    52.06(n)1
    49.14(a)1
      1 3A13
    312211  NM_080308.31  NP_525047.11 
    worm
    (Caenorhabditis elegans)
    Secernentea lin-451 , 3 Expression: head neurons, neurons3
    lin-451
    54(a)3
    52.97(n)1
    50.97(a)1
      IV(6743426-6747592)3
    1774361  NM_171367.51  NP_741430.31 


    ENSEMBL Gene Tree for BRAF (if available)
    TreeFam Gene Tree for BRAF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BRAF gene
    FPGT-TNNI3K2  MAP3K122  MAP3K112  KIAA18042  RAF12  KSR22  KSR12  MOS2  
    MAP3K92  MAP3K102  ARAF2  MAP3K72  TNNI3K2  ZAK2  MAP3K132  ILK2  
    Selected SIMAP similar genes for BRAF using alignment to 8 protein entries:     BRAF_HUMAN (see all proteins) (see all similar genes):
    RAF1    ARAF    MAP3K10    FPGT-TNNI3K    MARK2    BLK
    RPS6KA2    JAK2    MARK4    TESK2    TYRO3    MAP3K9
    MAP3K6    SIK3    MAP3K15    MERTK    NEK8    PHKG2

    Find genes that share paralogs with BRAF           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for BRAF
    PGOHUM00000241860


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BRAF (see all 3484)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0186174
    Melanoma4--see VAR_0186172 G A mis40--------
    VAR_0261184
    Cardiofaciocutaneous syndrome 1 (CFC1)4--see VAR_0261182 E K mis40--------
    VAR_0186244
    Familial non-Hodgkin lymphoma (NHL)4--see VAR_0186242 D G mis40--------
    VAR_0651724
    Cardiofaciocutaneous syndrome 1 (CFC1)4--see VAR_0651722 Q K mis40--------
    VAR_0403924
    A colorectal adenocarcinoma sample4--see VAR_0403922 G V mis40--------
    VAR_0586214
    LEOPARD syndrome 3 (LEOPARD3)4--see VAR_0586212 T P mis40--------
    VAR_0586314
    Cardiofaciocutaneous syndrome 1 (CFC1)4--see VAR_0586312 Q R mis40--------
    VAR_0586294
    Cardiofaciocutaneous syndrome 1 (CFC1)4--see VAR_0586292 K Q mis40--------
    VAR_0586284
    Cardiofaciocutaneous syndrome 1 (CFC1)4--see VAR_0586282 T R mis40--------
    VAR_0186164
    A colorectal cancer cell line4--see VAR_0186162 G V mis40--------

    HapMap Linkage Disequilibrium report for BRAF (140419127 - 140624564 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for BRAF:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672232CNV Deletion23128226
    esv2656982CNV Deletion23128226
    esv2735245CNV Deletion23290073
    nsv831158CNV Loss17160897
    nsv518139CNV Loss19592680

    Human Gene Mutation Database (HGMD): BRAF
    Selected Site Specific Mutation Identification with PCR Assays for BRAF (see all 38):
    Cosmic IdAA Change
    463p.E586K
    461p.G469E
    6265p.K601N
    458p.G469S
    462p.N581S
    Selected Site Specific Cancer Mutation PCR Panels containing BRAF (see all 31):
    Breast Cancer
    Receptor Tyrosine Kinase (RTK) (Panel II)
    Cancer Comprehensive Panel 384HT
    Lung Cancer
    SeqTarget long-range PCR primers for resequencing BRAF
    DNA2.0 Custom Variant and Variant Library Synthesis for BRAF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 164757   
    OMIM disorders: 211980  115150  613706  613707  
    UniProtKB/Swiss-Prot: BRAF_HUMAN, P15056
  • Note=Defects in BRAF are found in a wide range of cancers
  • Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from
    the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with
    progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon
    and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Note=The disease
    may be caused by mutations affecting the gene represented in this entry
  • Lung cancer (LNCR) [MIM:211980]: A common malignancy affecting tissues of the lung. The most common form
    of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes:
    squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced
    stage and has a poor prognosis. Note=The gene represented in this entry is involved in disease pathogenesis
  • Familial non-Hodgkin lymphoma (NHL) [MIM:605027]: Cancer that starts in cells of the lymph system, which
    is part of the body's immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes,
    fever and weight loss. Note=The gene represented in this entry is involved in disease pathogenesis
  • Cardiofaciocutaneous syndrome 1 (CFC1) [MIM:115150]: A multiple congenital anomaly disorder characterized
    by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic
    stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with
    ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized
    ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead
    with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal
    bridge, and posteriorly angulated ears with prominent helices. Note=The disease is caused by mutations affecting
    the gene represented in this entry
  • Noonan syndrome 7 (NS7) [MIM:613706]: A form of Noonan syndrome, a disease characterized by short
    stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated
    ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can
    include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits,
    multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk
    of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of
    myelomonocytic cells. Note=The disease is caused by mutations affecting the gene represented in this entry
  • LEOPARD syndrome 3 (LEOPARD3) [MIM:613707]: A disorder characterized by lentigines, electrocardiographic
    conduction abnormalities, ocular hypertelorism, pulmonic stenosis, abnormalities of genitalia, retardation of
    growth, and sensorineural deafness. Note=The disease is caused by mutations affecting the gene represented in
    this entry
  • Note=A chromosomal aberration involving BRAF is found in pilocytic astrocytomas. A tandem duplication of
    2 Mb at 7q34 leads to the expression of a KIAA1549-BRAF fusion protein with a constitutive kinase activity and
    inducing cell transformation

  • Selected diseases for BRAF (see all 56):    
    About MalaCards
    hairy cell leukemia    noonan syndrome 7    cardiofaciocutaneous syndrome    braf-related leopard syndrome
    leopard syndrome 3    braf-related noonan syndrome    braf-related cardiofaciocutaneous syndrome    hashimoto-pritzker syndrome
    craniopharyngioma    non-small cell lung carcinoma    mature b-cell neoplasm    adenocarcinoma of lung, response to tyrosine kinase inhibitor in
    nonsmall cell lung cancer, somatic    lung cancer, protection against    familial non-hodgkin lymphoma    leopard syndrome 1
    nonsmall cell lung cancer, response to tyrosine kinase inhibitor in    pilocytic astrocytoma    colonic adenoma recurrence, reduced risk of    uv-sensitive syndrome 3

    1 disease from the University of Copenhagen DISEASES database for BRAF:
    Melanoma

    Find genes that share disorders with BRAF           About GenesLikeMe

    Selected Novoseek inferred disease relationships for BRAF gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thyroid papillary carcinoma 91.4 159 15968271 (6), 17060774 (4), 20012784 (3), 15095090 (2) (see all 99)
    cfc syndrome 89.8 17 18651097 (2), 17366577 (2), 17551924 (2), 19376813 (2) (see all 12)
    microsatellite instability 89.4 103 16403224 (4), 18718023 (3), 15221372 (2), 18517279 (2) (see all 87)
    papillary thyroid cancer 86.7 58 16487015 (3), 16174717 (2), 12970315 (2), 16708643 (2) (see all 41)
    melanoma 85.4 857 15824163 (9), 15917418 (8), 17699719 (8), 15060100 (7) (see all 99)
    somatic mutations 81.4 66 20200438 (3), 16567964 (2), 14688025 (2), 14612909 (1) (see all 54)
    thyroid cancer 80.5 69 17878251 (5), 19878585 (5), 12970315 (3), 17179987 (3) (see all 40)
    thyroid carcinoma anaplastic 79.9 20 15195111 (7), 16533790 (2), 15880523 (1), 17878251 (1) (see all 11)
    colorectal cancer 79.9 211 14734469 (7), 17924122 (6), 15782118 (5), 15340260 (5) (see all 99)
    tumors 74.1 721 16199894 (6), 18473997 (6), 18235983 (5), 19919912 (5) (see all 99)

    GeneTests: BRAF
    GeneReviews: BRAF
    Genetic Association Database (GAD): BRAF
    Human Genome Epidemiology (HuGE) Navigator: BRAF (256 documents)

    Export disorders for BRAF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BRAF gene, integrated from 10 sources (see all 1871):
    (articles sorted by number of sources associating them with BRAF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies. (PubMed id 2284096)1, 2, 3 Sithanandam G.... Rapp U.R. (Oncogene 1990)
    2. KRAS or BRAF mutation status is a useful predictor of sensitivity to MEK inhibition in ovarian cancer. (PubMed id 19018267)1, 4, 9 Nakayama N....Miyazaki K. (Br. J. Cancer 2008)
    3. KRAS and BRAF mutations in prostate carcinomas of Chinese patients. (PubMed id 20303012)1, 4, 9 Shen Y....Zhu J. (Cancer Genet. Cytogenet. 2010)
    4. BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer. (PubMed id 16174717)1, 4, 9 Xing M....Ladenson P.W. (J. Clin. Endocrinol. Metab. 2005)
    5. BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in colorectal carcinogenesis? (PubMed id 18782444)1, 4, 9 Velho S....Seruca R. (BMC Cancer 2008)
    6. BRAF mutations in non-Hodgkin's lymphoma. (PubMed id 14612909)1, 2, 9 Lee J.W.... Lee S.H. (Br. J. Cancer 2003)
    7. Molecular analysis of PIK3CA, BRAF, and RAS oncogenes in periampullary and ampullary adenomas and carcinomas. (PubMed id 19440799)1, 4, 9 SchAPnleben F....Su G.H. (J. Gastrointest. Surg. 2009)
    8. No Evidence for BRAF as a melanoma/nevus susceptibility gene. (PubMed id 15824163)1, 4, 9 Jackson S....Newton Bishop J.A. (amp 2005)
    9. Investigation of V600E BRAF mutation in papillary thyroid carcinoma in the Polish population. (PubMed id 17693984)1, 4, 9 BrzeziaA8ska E....LewiA8ski A. (Neuro Endocrinol. Lett. 2007)
    10. BRAF gene is somatically mutated but does not make a major contribution to malignant melanoma susceptibility: the Italian Melanoma Intergroup Study. (PubMed id 14722037)1, 4, 9 Casula M....Palmieri G. (J. Clin. Oncol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 673 HGNC: 1097 AceView: BRAF Ensembl:ENSG00000157764 euGenes: HUgn673
    ECgene: BRAF Kegg: 673 H-InvDB: BRAF

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for BRAF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for BRAF Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=BRAF[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BRAF gene:
    Search GeneIP for patents involving BRAF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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