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Aliases for BPY2B Gene

Aliases for BPY2B Gene

  • Basic Charge, Y-Linked, 2B 2 3
  • Variably Charged Protein Y 2 3 4
  • Basic Charge, Y-Linked 2 3 4
  • VCY2B 3 4
  • Basic Protein On Y Chromosome 2 3
  • Variable Charge, Y-Linked, 2 3
  • BPY2 BPY2B BPY2C 4
  • BPY2A 4
  • VCY2A 4
  • VCY2C 4
  • VCY2 4

External Ids for BPY2B Gene

Previous GeneCards Identifiers for BPY2B Gene

  • GC0YP023476
  • GC0YU900266
  • GC0YP025173
  • GC0YP026764
  • GC0YP017912

Summaries for BPY2B Gene

Entrez Gene Summary for BPY2B Gene

  • This gene is located in the nonrecombining portion of the Y chromosome, and expressed specifically in testis. The encoded protein interacts with ubiquitin protein ligase E3A and may be involved in male germ cell development and male infertility. Three nearly identical copies of this gene exist on chromosome Y; two copies are part of a palindromic region. This record represents the more centromeric copy within the palindrome. [provided by RefSeq, Jul 2008]

GeneCards Summary for BPY2B Gene

BPY2B (Basic Charge, Y-Linked, 2B) is a Protein Coding gene. GO annotations related to this gene include HECT domain binding. An important paralog of this gene is BPY2C.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BPY2B Gene

Genomics for BPY2B Gene

Genomic Location for BPY2B Gene

24,607,560 bp from pter
24,639,207 bp from pter
31,648 bases
Plus strand

Genomic View for BPY2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BPY2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BPY2B Gene

No data available for Regulatory Elements for BPY2B Gene

Proteins for BPY2B Gene

  • Protein details for BPY2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Testis-specific basic protein Y 2
    Protein Accession:

    Protein attributes for BPY2B Gene

    106 amino acids
    Molecular mass:
    12063 Da
    Quaternary structure:
    • Interacts with MAP1S. Interacts with UBE3A (via HECT domain).
    • Interacts with MAP1S. Interacts with UBE3A (via HECT domain).
    • Interacts with MAP1S. Interacts with UBE3A (via HECT domain).

neXtProt entry for BPY2B Gene

Proteomics data for BPY2B Gene at MOPED

Post-translational modifications for BPY2B Gene

No Post-translational modifications

Other Protein References for BPY2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BPY2B Gene

Domains & Families for BPY2B Gene

Protein Domains for BPY2B Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the VCX/VCY family.
  • Belongs to the VCX/VCY family.
genes like me logo Genes that share domains with BPY2B: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for BPY2B Gene

Function for BPY2B Gene

Gene Ontology (GO) - Molecular Function for BPY2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14627543
GO:0032399 HECT domain binding IPI 12207887
genes like me logo Genes that share ontologies with BPY2B: view

Animal Model Products

CRISPR Products

miRNA for BPY2B Gene

miRTarBase miRNAs that target BPY2B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BPY2B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for BPY2B Gene

Localization for BPY2B Gene

Subcellular locations from

Jensen Localization Image for BPY2B Gene COMPARTMENTS Subcellular localization image for BPY2B gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for BPY2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12724276
genes like me logo Genes that share ontologies with BPY2B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BPY2B Gene

Pathways & Interactions for BPY2B Gene

SuperPathways for BPY2B Gene

No Data Available

Interacting Proteins for BPY2B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: O14599-VCY2_HUMAN ENSP00000371829 for BPY2B Gene via I2D UniProtKB STRING

Gene Ontology (GO) - Biological Process for BPY2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis IMP 12724276
GO:0007338 single fertilization TAS 9381176
genes like me logo Genes that share ontologies with BPY2B: view

No data available for Pathways by source and SIGNOR curated interactions for BPY2B Gene

Drugs & Compounds for BPY2B Gene

No Compound Related Data Available

Transcripts for BPY2B Gene

mRNA/cDNA for BPY2B Gene

(1) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BPY2B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BPY2B Gene

No ASD Table

Relevant External Links for BPY2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BPY2B Gene

mRNA expression in normal human tissues for BPY2B Gene

Protein differential expression in normal tissues from HIPED for BPY2B Gene

This gene is overexpressed in Kidney (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BPY2B Gene

SOURCE GeneReport for Unigene cluster for BPY2B Gene Hs.632848

mRNA Expression by UniProt/SwissProt for BPY2B Gene

Tissue specificity: Expressed exclusively in testis. Expressed in ejaculated spermatozoa of germ cell. Expressed in the nuclei of spermatogonia, spermatocytes, and round spermatids, except elongated spermatids (at protein level).
genes like me logo Genes that share expression patterns with BPY2B: view

Protein tissue co-expression partners for BPY2B Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for BPY2B Gene

Orthologs for BPY2B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for BPY2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BPY2 36
  • 98 (a)
BPY2 36
  • 98 (a)
Species with no ortholog for BPY2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BPY2B Gene

Gene Tree for BPY2B (if available)
Gene Tree for BPY2B (if available)

Paralogs for BPY2B Gene

Paralogs for BPY2B Gene

genes like me logo Genes that share paralogs with BPY2B: view

Variants for BPY2B Gene

Sequence variations from dbSNP and Humsavar for BPY2B Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type MAF
rs163703 -- 24,631,011(+) TGTGA(C/T)TCTCA intron-variant
rs111237964 -- 24,617,647(+) AACCC(C/T)ATTTC upstream-variant-2KB
rs111441574 -- 24,630,993(+) GGCTT(A/G)ACATC intron-variant
rs112996964 -- 24,617,782(+) TGCCA(C/T)TGCAC upstream-variant-2KB
rs370710060 -- 24,634,806(+) AAGGA(A/G)GATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BPY2B Gene

Variant ID Type Subtype PubMed ID
dgv2504e1 CNV Complex 17122850
dgv2505e1 CNV Complex 17122850
dgv2506e1 CNV Complex 17122850
nsv10034 CNV Loss 18304495
essv10843 CNV CNV 17122850
dgv2507e1 CNV Complex 17122850
nsv442825 CNV CNV 18776908
dgv2508e1 CNV Complex 17122850
dgv2509e1 CNV Complex 17122850
dgv2510e1 CNV Complex 17122850
nsv515230 CNV Complex 21397061
nsv469740 CNV Complex 16826518
nsv442826 CNV CNV 18776908
nsv515231 CNV Complex 21397061
dgv2513e1 CNV Complex 17122850

Relevant External Links for BPY2B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for BPY2B Gene

Disorders for BPY2B Gene

Relevant External Links for BPY2B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with BPY2B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BPY2B Gene

Publications for BPY2B Gene

  1. Identification and characterization of a VCY2 interacting protein-1; VCY2IP-1, a MAP-like protein. (PMID: 14627543) Wong E.Y. … Yeung W.S. (Biol. Reprod. 2004) 67
  2. A family of human Y chromosomes has dispersed throughout northern Eurasia despite a 1.8-Mb deletion in the azoospermia factor c region. (PMID: 15177557) Repping S. … Rozen S. (Genomics 2004) 67
  3. Specific expression of VCY2 in human male germ cells and its involvement in the pathogenesis of male infertility. (PMID: 12724276) Tse J.Y. … Yeung W.S. (Biol. Reprod. 2003) 67
  4. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H. … Page D.C. (Nature 2003) 67
  5. VCY2 protein interacts with the HECT domain of ubiquitin-protein ligase E3A. (PMID: 12207887) Wong E.Y. … Yeung W.S. (Biochem. Biophys. Res. Commun. 2002) 67

Products for BPY2B Gene

Sources for BPY2B Gene

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