BPY2 Gene
protein-coding GIFtS: 41
GCID: GC0YP025130
|
|
basic charge, Y-linked, 2(Previous names: variable charge, Y-linked, 2 )
(Previous symbol: VCY2)
| |
Aliases
for BPY2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Basic Charge, Y-Linked, 21 2 | | Basic Protein On Y Chromosome 22 | | BPY2A1 2 3 | | Testis-Specific Basic Protein On Y, 22 | | VCY21 2 3 | | Testis-Specific Basic Protein Y 22 | | VCY2A1 2 3 | | VCY2B3 | | Variable Charge, Y-Linked, 21 2 | | VCY2C3 | | Variably Charged Protein Y 22 3 | | Basic Charge, Y-Linked 23 |
Export aliases for BPY2 gene to outside databasesPrevious GC identifers: GC0YU900229 GC0YP023468 GC0YP023539 |
Summaries
for BPY2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for BPY2:
This gene is located in the nonrecombining portion of the Y chromosome, and expressed specifically in testis. Theencoded protein interacts with ubiquitin protein ligase E3A and may be involved in male germ cell development and maleinfertility. Three nearly identical copies of this gene exist on chromosome Y; two copies are part of a palindromicregion. This record represents the copy outside of the palidromic region. (provided by RefSeq, Jul 2008)
Gene Wiki entry for BPY2
|
Genomic Views
for BPY2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000024.9 NT_011903.12
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for BPY2
Other transcription factors
Search SABiosciences Chromatin IP Primers for BPY2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BPY2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Yq11 Ensembl cytogenetic band: Yq11.223 HGNC cytogenetic band: Yq11.223BPY2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome Y GeneLoc Exon Structure GeneLoc location for GC0YP025130: view genomic region
(about GC identifiers)
Start:
|
25,130,410 bp from pter |
End:
|
25,151,612 bp from pter |
Size:
|
21,203 bases |
Orientation:
|
plus strand |
|
Proteins
for BPY2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: VCY2_HUMAN, O14599 (See
protein sequence)Recommended Name: Testis-specific basic protein Y 2 Size: 106 amino acids; 12063 Da
Subunit: Interacts with MAP1S. Interacts with UBE3A (via HECT domain)Explore the universe of human proteins at neXtProt for BPY2: NX_O14599
BPY2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004669.2
ENSEMBL proteins: ENSP00000329106 ENSP00000372028
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
-- | -- |
BPY2 for ontologies About GeneDecksing
BPY2 Antibody Products:
Assay Products for BPY2: |
Protein
Domains /
Families
for BPY2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: O14599 UniProtKB/Swiss-Prot: VCY2_HUMAN, O14599Similarity: Belongs to the VCX/VCY family |
Function
for BPY2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for BPY2:basic protein on chromosome Y,2,testis specific,1,testis specific,in the AZFC deleted region
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BPY2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BPY2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: BPY2 (NM_004678) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BPY2 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat BPY2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BPY2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- | | GO:0032399 | HECT domain binding |
-- | -- |
BPY2 for ontologies About GeneDecksing
|
Pathways & Interactions
for BPY2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BPY2
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for BPY2 (O145991, 3 ENSP000003291064) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007283 | spermatogenesis |
-- | -- | | GO:0007338 | single fertilization |
-- | -- |
BPY2 for ontologies About GeneDecksing
|
Drugs & Compounds
for BPY2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for BPY2
Search CenterWatch for drugs/clinical trials and news about BPY2 / VCY2
|
Transcripts
for BPY2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for BPY2 gene: NM_004678.2 Unigene Cluster for BPY2: Basic charge, Y-linked, 2 Hs.664724 [show with all ESTs]Unigene Representative Sequence: NM_0046782 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000331070(uc011nbj.2) ENST00000382585(uc004fvj.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BPY2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BPY2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: BPY2 (NM_004678) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for BPY2 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat BPY2 |
Additional cDNA sequence: AF000980.1 BC171776.1 BC171778.1 BC171795.1 BC171796.1 3 DOTS entries: DT.120653943 DT.120654199 DT.40122102 4 AceView cDNA sequences: NM_001002761 NM_001002760 AF000980 NM_004678
GeneLoc Exon Structure
|
Expression
for BPY2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| BPY2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See BPY2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for BPY2
SOURCE GeneReport for Unigene cluster: Hs.664724
UniProtKB/Swiss-Prot: VCY2_HUMAN, O14599Tissue specificity: Expressed exclusively in testis. Expressed in ejaculated spermatozoa of germ cell. Expressed in thenuclei of spermatogonia, spermatocytes, and round spermatids, except elongated spermatids (at protein level)
SABiosciences Custom PCR Arrays for BPY2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BPY2
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat BPY2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BPY2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BPY2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BPY2 |
Orthologs
for BPY2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for BPY2 (if available)
TreeFam Gene Tree for BPY2 (if available) |
Paralogs
for BPY2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for BPY2 gene
- BPY2B2 BPY2C2
BPY2 for paralogs About GeneDecksing
|
Genomic Variants
for BPY2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr Y pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for BPY2 (25130410 - 25151612 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for BPY2
9 CNVs: 33192 4185 33193 83969 97229 2289 38830 97228 38829 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for BPY2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
BPY2 for disorders About GeneDecksing
OMIM gene information: 400013
OMIM disorders: --
4  diseases for BPY2: About MalaCardsmale infertility infertility azoospermia y chromosome infertility
Human Genome Epidemiology (HuGE) Navigator: BPY2 (2 documents)
Export disorders for BPY2 gene to outside databases
|
Publications
for BPY2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for BPY2 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with BPY2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- VCY2 protein interacts with the HECT domain of ubiquitin-protein ligase E3A. (PubMed id 12207887)1, 2, 9 Wong E.Y....Yeung W.S. (2002)
- Identification and characterization of a VCY2 interacting protein-1; VCY2IP-1, a MAP-like protein. (PubMed id 14627543)1, 2 Wong E.Y.... Yeung W.S. (2004)
- Specific expression of VCY2 in human male germ cells and its involvement in the pathogenesis of male infertility. (PubMed id 12724276)1, 2 Tse J.Y....Yeung W.S. (2003)
- The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PubMed id 12815422)1, 2 Skaletsky H.... Page D.C. (2003)
- Functional coherence of the human Y chromosome. (PubMed id 9381176)1, 2 Lahn B.T. and Page D.C. (1997)
- Differential effect of specific gr/gr deletion subtyp es on spermatogenesis in the Chinese Han population. (PubMed id 20039973)1 Yang Y....Zhang S. (2009)
- Alu sequence variants of the BPY2 gene in proven fertile and infertile men with Sertoli cell-only phenotype. (PubMed id 17511727)1 Choi J....Namiki M. (2007)
- A family of human Y chromosomes has dispersed throughout northern Eurasia despite a 1.8-Mb deletion in the azoospermia factor c region. (PubMed id 15177557)1 Repping S....Rozen S. (2004)
- Toward a complete human genome sequence. (PubMed id 9847074)1 Wilson R. (1998)
- Y Chromosome Infertility (PubMed id 20301513)1 Disteche C.M. (1993)
|
External Searches for BPY2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing BPY2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing BPY2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing BPY2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for BPY2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for BPY2 gene:
Search GeneIP for patents involving BPY2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for BPY2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for BPY2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for BPY2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for BPY2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for BPY2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for BPY2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for BPY2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for BPY2 | | OriGene Custom Protein Services for BPY2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat BPY2 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing BPY2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BPY2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat BPY2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat BPY2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat BPY2 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for BPY2 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | BPY2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BPY2 |
|  |  |  | | | | Search ThermoFisher Antibodies for BPY2 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat BPY2 |
|
|
|
|
