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Aliases for BPY2 Gene

Aliases for BPY2 Gene

  • Basic Charge, Y-Linked, 2 2 3
  • Variable Charge, Y-Linked, 2 2 3
  • Variably Charged Protein Y 2 3 4
  • BPY2A 3 4
  • VCY2A 3 4
  • VCY2 3 4
  • Testis-Specific Basic Protein On Y, 2 3
  • Testis-Specific Basic Protein Y 2 3
  • Basic Protein On Y Chromosome 2 3
  • Basic Charge, Y-Linked 2 4
  • BPY2 BPY2B BPY2C 4
  • VCY2B 4
  • VCY2C 4

External Ids for BPY2 Gene

Previous HGNC Symbols for BPY2 Gene

  • VCY2

Previous GeneCards Identifiers for BPY2 Gene

  • GC0YU900229
  • GC0YP023468
  • GC0YP023539
  • GC0YP025130

Summaries for BPY2 Gene

Entrez Gene Summary for BPY2 Gene

  • This gene is located in the nonrecombining portion of the Y chromosome, and expressed specifically in testis. The encoded protein interacts with ubiquitin protein ligase E3A and may be involved in male germ cell development and male infertility. Three nearly identical copies of this gene exist on chromosome Y; two copies are part of a palindromic region. This record represents the copy outside of the palidromic region. [provided by RefSeq, Jul 2008]

GeneCards Summary for BPY2 Gene

BPY2 (Basic Charge, Y-Linked, 2) is a Protein Coding gene. Diseases associated with BPY2 include y chromosome infertility and male infertility. An important paralog of this gene is BPY2B.

Gene Wiki entry for BPY2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BPY2 Gene

Genomics for BPY2 Gene

Genomic Location for BPY2 Gene

22,973,819 bp from pter
23,005,465 bp from pter
31,647 bases
Plus strand

Genomic View for BPY2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BPY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BPY2 Gene

No data available for Regulatory Elements for BPY2 Gene

Proteins for BPY2 Gene

  • Protein details for BPY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Testis-specific basic protein Y 2
    Protein Accession:
    Secondary Accessions:

    Protein attributes for BPY2 Gene

    106 amino acids
    Molecular mass:
    12063 Da
    Quaternary structure:
    • Interacts with MAP1S. Interacts with UBE3A (via HECT domain).

neXtProt entry for BPY2 Gene

Proteomics data for BPY2 Gene at MOPED

Post-translational modifications for BPY2 Gene

No Post-translational modifications

Other Protein References for BPY2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for BPY2 Gene

Domains for BPY2 Gene

Protein Domains for BPY2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the VCX/VCY family.
  • Belongs to the VCX/VCY family.
genes like me logo Genes that share domains with BPY2: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for BPY2 Gene

Function for BPY2 Gene

Molecular function for BPY2 Gene

GENATLAS Biochemistry:
basic protein on chromosome Y,2,testis specific,1,testis specific,in the AZFC deleted region

Gene Ontology (GO) - Molecular Function for BPY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14627543
GO:0032399 HECT domain binding IPI 12207887
genes like me logo Genes that share ontologies with BPY2: view

Animal Model Products

CRISPR Products

miRNA for BPY2 Gene

miRTarBase miRNAs that target BPY2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BPY2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for BPY2 Gene

Localization for BPY2 Gene

Subcellular locations from

Jensen Localization Image for BPY2 Gene COMPARTMENTS Subcellular localization image for BPY2 gene
Compartment Confidence
nucleus 4
extracellular 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for BPY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12724276
genes like me logo Genes that share ontologies with BPY2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BPY2 Gene

Pathways for BPY2 Gene

SuperPathways for BPY2 Gene

No Data Available

Interacting Proteins for BPY2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000329106 O14599-VCY2_HUMAN for BPY2 Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for BPY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis IMP 12724276
GO:0007338 single fertilization TAS 9381176
genes like me logo Genes that share ontologies with BPY2: view

No data available for Pathways by source for BPY2 Gene

Transcripts for BPY2 Gene

mRNA/cDNA for BPY2 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BPY2 Gene

Basic charge, Y-linked, 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BPY2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BPY2 Gene

No ASD Table

Relevant External Links for BPY2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BPY2 Gene

mRNA expression in normal human tissues for BPY2 Gene

mRNA differential expression in normal tissues according to GTEx for BPY2 Gene

This gene is overexpressed in Testis (53.0).

Protein differential expression in normal tissues for BPY2 Gene

This gene is overexpressed in Kidney (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BPY2 Gene

SOURCE GeneReport for Unigene cluster for BPY2 Gene Hs.664724

mRNA Expression by UniProt/SwissProt for BPY2 Gene

Tissue specificity: Expressed exclusively in testis. Expressed in ejaculated spermatozoa of germ cell. Expressed in the nuclei of spermatogonia, spermatocytes, and round spermatids, except elongated spermatids (at protein level).
genes like me logo Genes that share expressions with BPY2: view

Expression partners for BPY2 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for BPY2 Gene

Orthologs for BPY2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for BPY2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia BPY2 36
  • 98 (a)
BPY2 36
  • 98 (a)
Species with no ortholog for BPY2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BPY2 Gene

Gene Tree for BPY2 (if available)
Gene Tree for BPY2 (if available)

Paralogs for BPY2 Gene

Paralogs for BPY2 Gene

genes like me logo Genes that share paralogs with BPY2: view

Variants for BPY2 Gene

Sequence variations from dbSNP and Humsavar for BPY2 Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type MAF
rs367868528 -- 22,996,723(+) CTGGC(-/C)ACAGG intron-variant
rs55922033 -- 23,004,604(+) ACGTG(A/G)CAATG intron-variant
rs163707 -- 23,004,577(+) AGGAT(A/G)TCATA intron-variant
rs163705 -- 23,000,507(+) ctctt(A/G)gctag intron-variant
rs163704 -- 22,998,928(+) CATGT(A/G)CCAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BPY2 Gene

Variant ID Type Subtype PubMed ID
dgv2504e1 CNV Complex 17122850
dgv2505e1 CNV Complex 17122850
dgv2506e1 CNV Complex 17122850
nsv10034 CNV Loss 18304495
essv10843 CNV CNV 17122850
dgv2507e1 CNV Complex 17122850
nsv442825 CNV CNV 18776908
dgv2508e1 CNV Complex 17122850
dgv2509e1 CNV Complex 17122850
dgv2510e1 CNV Complex 17122850
nsv515230 CNV Complex 21397061
nsv469740 CNV Complex 16826518
nsv442826 CNV CNV 18776908
nsv515231 CNV Complex 21397061
dgv2513e1 CNV Complex 17122850

Relevant External Links for BPY2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BPY2 Gene

Disorders for BPY2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for BPY2 Gene in MalaCards »

(3) Diseases for BPY2 Gene

Relevant External Links for BPY2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with BPY2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for BPY2 Gene

Publications for BPY2 Gene

  1. VCY2 protein interacts with the HECT domain of ubiquitin-protein ligase E3A. (PMID: 12207887) Wong E.Y. … Yeung W.S. (Biochem. Biophys. Res. Commun. 2002) 3 4 23
  2. Functional coherence of the human Y chromosome. (PMID: 9381176) Lahn B.T. … Page D.C. (Science 1997) 3 4
  3. Specific expression of VCY2 in human male germ cells and its involvement in the pathogenesis of male infertility. (PMID: 12724276) Tse J.Y. … Yeung W.S. (Biol. Reprod. 2003) 3 4
  4. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PMID: 12815422) Skaletsky H. … Page D.C. (Nature 2003) 3 4
  5. Identification and characterization of a VCY2 interacting protein-1; VCY2IP-1, a MAP-like protein. (PMID: 14627543) Wong E.Y. … Yeung W.S. (Biol. Reprod. 2004) 3 4

Products for BPY2 Gene

Sources for BPY2 Gene

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