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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

BPNT1 Gene

protein-coding   GIFtS: 60
GCID: GC01M220230

3'(2'), 5'-Bisphosphate Nucleotidase 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
3'(2'), 5'-Bisphosphate Nucleotidase 11 2     3'(2'),5'-Bisphosphate Nucleotidase 12
Bisphosphate 3'-Nucleotidase 12 3     BPntase2
PIP2 3     PAP-inositol-1,4-phosphatase2
PAP-Inositol 1,4-Phosphatase2 3     EC 3.1.38
EC 3.1.3.73 8     

External Ids:    HGNC: 10961   Entrez Gene: 103802   Ensembl: ENSG000001628137   OMIM: 6040535   UniProtKB: O958613   

Export aliases for BPNT1 gene to outside databases

Previous GC identifers: GC01M218827 GC01M216074 GC01M216777 GC01M217287 GC01M216619 GC01M218297 GC01M190905


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for BPNT1 Gene:
BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent
phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive
inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role
in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may
account for lithium-induced nephrotoxicity. (provided by RefSeq, Jul 2008)

GeneCards Summary for BPNT1 Gene: 
BPNT1 (3'(2'), 5'-bisphosphate nucleotidase 1) is a protein-coding gene. Diseases associated with BPNT1 include neonatal jaundice, and jaundice, and among its related super-pathways are Metabolic pathways and Phase II conjugation. GO annotations related to this gene include 3'(2'),5'-bisphosphate nucleotidase activity and magnesium ion binding. An important paralog of this gene is IMPAD1.

UniProtKB/Swiss-Prot: BPNT1_HUMAN, O95861
Function: Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and
3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol
1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P,
Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_167186.1  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the BPNT1 gene promoter:
         FOXD3   Ik-3   GATA-2   Arnt   GATA-1   HEN1   POU2F1   POU2F1a   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBPNT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for BPNT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat BPNT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q41   Ensembl cytogenetic band:  1q41   HGNC cytogenetic band: 1q42

BPNT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BPNT1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M220230:  view genomic region     (about GC identifiers)

Start:
220,230,824 bp from pter      End:
220,263,804 bp from pter
Size:
32,981 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: BPNT1_HUMAN, O95861 (See protein sequence)
Recommended Name: 3'(2'),5'-bisphosphate nucleotidase 1  
Size: 308 amino acids; 33392 Da
Cofactor: Magnesium
1 PDB 3D structure from and Proteopedia for BPNT1:
2WEF (3D)    
Secondary accessions: A8K7C8 D3DTA9 Q8WVL5 Q9UGJ3
Alternative splicing: 2 isoforms:  O95861-1   O95861-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BPNT1: NX_O95861

Explore proteomics data for BPNT1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95861

  • 4 DME Specific Peptides for BPNT1 (O95861)
     VWVDPLD  AVGGKLTD  EEILKQPCPSQYSAIKEEDLVVWVDP  VLRVGGAGNKIIQLIEGKASAYVFASPGCKKWDTCAPEVIL 

    BPNT1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    BPNT1 Protein Expression
    REFSEQ proteins: NP_006076.4  
    ENSEMBL proteins: 
     ENSP00000446828   ENSP00000346862   ENSP00000446953   ENSP00000446850   ENSP00000448740  
     ENSP00000449883   ENSP00000318852   ENSP00000410348   ENSP00000444398  
    Reactome Protein details: O95861
    Human Recombinant Protein Products for BPNT1: 
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    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for BPNT1
    Cloud-Clone Corp. Proteins for BPNT1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    BPNT1 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for BPNT1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR020550 Inositol_monophosphatase_CS
     IPR000760 Inositol_monophosphatase
     IPR020583 Inositol_monoP_metal-BS

    Graphical View of Domain Structure for InterPro Entry O95861

    ProtoNet protein and cluster: O95861

    UniProtKB/Swiss-Prot: BPNT1_HUMAN, O95861
    Similarity: Belongs to the inositol monophosphatase family


    BPNT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BPNT1_HUMAN, O95861
    Function: Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and
    3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol
    1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P,
    Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6
    Catalytic activity: Adenosine 3',5'-bisphosphate + H(2)O = adenosine 5'-phosphate + phosphate
    Enzyme regulation: Uncompetitive inhibition by micromolar concentrations of lithium. Competitive inhibition by
    inositol 1,4-bisphosphate

         Enzyme Numbers (IUBMB): EC 3.1.3.71 2 EC 3.1.32

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0004441inositol-1,4-bisphosphate 1-phosphatase activity IEA--
    GO:00084413'(2'),5'-bisphosphate nucleotidase activity IEA--
         
    BPNT1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for BPNT1:
     Decreased focal adhesion (FA)  

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Bpnt1):
     homeostasis/metabolism  liver/biliary system  mortality/aging  no phenotypic analysis 

    BPNT1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Bpnt1tm1Yrk for BPNT1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for BPNT1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for BPNT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for BPNT1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for BPNT1 

    miRNA
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    hsa-miR-607 hsa-miR-206 hsa-miR-613 hsa-miR-1 hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidBPNT1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for BPNT1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    2Biological oxidations
    Biological oxidations0.55
    Phase II conjugation0.55
    3Cytosolic sulfonation of small molecules
    Cytosolic sulfonation of small molecules0.52
    4Sulfur metabolism
    Sulfur metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for BPNT1
        Metabolism
    Biological oxidations
    Cytosolic sulfonation of small molecules
    Phase II conjugation


    2         Kegg Pathways  (Kegg details for BPNT1):
        Sulfur metabolism
    Metabolic pathways


    BPNT1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for BPNT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/18 Interacting proteins for BPNT1 (O958613 ENSP000003188524) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDA1Q9BW613I2D: score=1 
    IKBKEQ141643I2D: score=1 
    TRAF6Q9Y4K33I2D: score=1 
    UBA5Q9GZZ93I2D: score=1 
    CHST11ENSP000003057254STRING: ENSP00000305725
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006139nucleobase-containing compound metabolic process TAS10224133
    GO:0006805xenobiotic metabolic process TAS--
    GO:0007399nervous system development TAS10224133
    GO:0044281small molecule metabolic process TAS--
    GO:0046854phosphatidylinositol phosphorylation IEA--

    BPNT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for BPNT1

    9 HMDB Compounds for BPNT1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine 3',5'-diphosphate3,5-Diphosphoadenosine (see all 10)1053-73-2--
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine phosphosulfateAdenosine Phosphosulfate (see all 13)485-84-7--
    LithiumLi (see all 5)7439-93-2--
    MagnesiumMagnesium (see all 2)7439-95-4--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    Phosphoadenosine phosphosulfate3'-Phospho-5'-adenylyl sulfate (see all 9)482-67-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    ZolpidemAmbien (see all 7)82626-48-0--

    Search CenterWatch for drugs/clinical trials and news about BPNT1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for BPNT1 gene: 
    NM_006085.4  

    Unigene Cluster for BPNT1:

    3'(2'), 5'-bisphosphate nucleotidase 1
    Hs.406134  [show with all ESTs]
    Unigene Representative Sequence: NM_006085
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000469520 ENST00000354807 ENST00000482136 ENST00000463953 ENST00000498791
    ENST00000480959 ENST00000548668 ENST00000498237 ENST00000322067(uc001hma.3 uc010pug.2 uc010puh.2)
    ENST00000414869 ENST00000544404
    miRNA
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    hsa-miR-607 hsa-miR-206 hsa-miR-613 hsa-miR-1 hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidBPNT1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AJ249339.1 AK021941.1 AK291943.1 AK298476.1 AK300777.1 AK315962.1 BC017801.1 

    11 DOTS entries:

    DT.100026759  DT.40288530  DT.309993  DT.97843381  DT.100787582  DT.102823315  DT.91729031  DT.100026758 
    DT.121443346  DT.91729044  DT.100026757 

    24/106 AceView cDNA sequences (see all 106):

    BP343778 CR599062 BP374906 AL600860 CB137379 CB110606 BP373057 BP345650 
    CA488991 AL528197 AA206984 BU845985 AA832235 CB107792 BI666522 CB135855 
    AI128324 CB991224 AW406527 NM_006085 CA422020 BM467293 CB116894 AL583334 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for BPNT1    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
    SP1:                    -                                   -                           
    SP2:                    -                                                               
    SP3:                                                        -                           
    SP4:                    -     -                             -                           


    ECgene alternative splicing isoforms for BPNT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    BPNT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAATGTTCT
    BPNT1 Expression
    About this image


    See BPNT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for BPNT1

    SOURCE GeneReport for Unigene cluster: Hs.406134

    UniProtKB/Swiss-Prot: BPNT1_HUMAN, O95861
    Tissue specificity: Highly expressed in kidney, liver, pancreas and heart. Detected at lower levels in brain,
    placenta, lung and skeletal muscle

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BPNT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for BPNT1 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bpnt11 , 5 bisphosphate 3'-nucleotidase 11, 5 85.06(n)1
    91.88(a)1
      1 (89.49 cM)5
    238271  NM_011794.31  NP_035924.21 
     1853321495 
    chicken
    (Gallus gallus)
    Aves BPNT11 3'(2'), 5'-bisphosphate nucleotidase 1 77.02(n)
    80.72(a)
      421347  NM_001012874.2  NP_001012892.2 
    lizard
    (Anolis carolinensis)
    Reptilia BPNT16
    Uncharacterized protein
    83(a)
    1 ↔ 1
    1(243259730-243271730)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.38092 Transcribed sequence with moderate similarity to protein more 77.49(n)    AL879086.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.153862 Transcribed sequence with weak similarity to protein more 75.3(n)    AL918203.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG77891 , 3 3'(2'),5'-bisphosphate nucleotidase3
    CG77891
    50(a)3
    52.98(n)1
    51.66(a)1
      99C13
    435161  NM_143471.21  NP_651728.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ZK430.23
    tag-2311
    ammonium transport protein3
    Protein TAG-2311
    42(a)3
    54.83(n)1
    47.59(a)1
      II(4420303-4422207)3
    1737771  NM_062379.41  NP_494780.11 


    ENSEMBL Gene Tree for BPNT1 (if available)
    TreeFam Gene Tree for BPNT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for BPNT1 gene
    IMPAD12  
    1 SIMAP similar gene for BPNT1 using alignment to 8 protein entries:     BPNT1_HUMAN (see all proteins):
    IMPAD1

    BPNT1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/631 SNPs in BPNT1 are shown (see all 631)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1151905751,2
    F--220230423(+) AAATCG/ATTGGG 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1816517911,2
    --220230528(+) ACCTCA/TGCCTC 1 -- ds50010--------
    rs1493455041,2
    C--220230603(+) TGCCCA/GGCTAA 1 -- ds50010--------
    rs1862337701,2
    --220230613(+) ATTTTC/TGTATT 1 -- ds50010--------
    rs1909510011,2
    C--220230733(+) CACTGC/TGCCTG 1 -- ds50010--------
    rs1823406731,2
    --220230768(+) AATCTC/TCCTAG 1 -- ds50010--------
    rs118039601,2
    C,F,H--220230785(+) ctgatA/Gtgcag 1 -- ds50017Minor allele frequency- G:0.07NS EA NA CSA WA 538
    rs1414297861,2
    --220230791(+) TGCAGC/TTGAGT 1 -- ds50010--------
    rs1504285671,2
    --220230931(+) TCTCTC/TATTGG 1 -- ut310--------
    rs1382417671,2
    C--220230943(+) AGGAAC/TAGAAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for BPNT1 (220230824 - 220263804 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for BPNT1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv4632CNV Insertion18451855
    nsv832636CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604053    OMIM disorders: --

    3 diseases for BPNT1:    About MalaCards
    neonatal jaundice    jaundice    ovarian cancer

    1 disease from the University of Copenhagen DISEASES database for BPNT1:
    Neonatal jaundice

    BPNT1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): BPNT1
    Human Genome Epidemiology (HuGE) Navigator: BPNT1 (1 document)

    Export disorders for BPNT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for BPNT1 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with BPNT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate. (PubMed id 10224133)1, 2, 3, 9 Spiegelberg B.D.... York J.D. (1999)
    2. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    9. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. (PubMed id 21565611)1 Sang L.... Jackson P.K. (2011)
    10. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10380 HGNC: 1096 AceView: BPNT1 Ensembl:ENSG00000162813 euGenes: HUgn10380
    ECgene: BPNT1 Kegg: 10380 H-InvDB: BPNT1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for BPNT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for BPNT1 gene:
    Search GeneIP for patents involving BPNT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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