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Aliases for BPNT1 Gene

Aliases for BPNT1 Gene

  • 3'(2'), 5'-Bisphosphate Nucleotidase 1 2
  • 3(2), 5-Bisphosphate Nucleotidase 1 2 3
  • Bisphosphate 3-Nucleotidase 1 3 4
  • PAP-Inositol 1,4-Phosphatase 3 4
  • EC 3.1.3.7 4 63
  • PIP 3 4
  • 3(2),5-Bisphosphate Nucleotidase 1 3
  • Epididymis Luminal Protein 20 3
  • PAP-Inositol-1,4-Phosphatase 3
  • EC 3.1.3 63
  • BPntase 3
  • HEL20 3

External Ids for BPNT1 Gene

Previous GeneCards Identifiers for BPNT1 Gene

  • GC01M218827
  • GC01M216074
  • GC01M216777
  • GC01M217287
  • GC01M216619
  • GC01M218297
  • GC01M220230
  • GC01M190905

Summaries for BPNT1 Gene

Entrez Gene Summary for BPNT1 Gene

  • BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq, Jul 2008]

GeneCards Summary for BPNT1 Gene

BPNT1 (3'(2'), 5'-Bisphosphate Nucleotidase 1) is a Protein Coding gene. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include magnesium ion binding and 3(2),5-bisphosphate nucleotidase activity. An important paralog of this gene is IMPAD1.

UniProtKB/Swiss-Prot for BPNT1 Gene

  • Converts adenosine 3-phosphate 5-phosphosulfate (PAPS) to adenosine 5-phosphosulfate (APS) and 3(2)-phosphoadenosine 5- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BPNT1 Gene

Genomics for BPNT1 Gene

Regulatory Elements for BPNT1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for BPNT1 Gene

Start:
220,057,482 bp from pter
End:
220,090,462 bp from pter
Size:
32,981 bases
Orientation:
Minus strand

Genomic View for BPNT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BPNT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BPNT1 Gene

Proteins for BPNT1 Gene

  • Protein details for BPNT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95861-BPNT1_HUMAN
    Recommended name:
    3(2),5-bisphosphate nucleotidase 1
    Protein Accession:
    O95861
    Secondary Accessions:
    • A8K7C8
    • B4DPS5
    • B4DUS9
    • D3DTA9
    • Q8WVL5
    • Q9UGJ3

    Protein attributes for BPNT1 Gene

    Size:
    308 amino acids
    Molecular mass:
    33392 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for BPNT1 Gene

    Alternative splice isoforms for BPNT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BPNT1 Gene

Proteomics data for BPNT1 Gene at MOPED

Post-translational modifications for BPNT1 Gene

  • Ubiquitination at Lys49
  • Modification sites at PhosphoSitePlus

Domains for BPNT1 Gene

Protein Domains for BPNT1 Gene

Graphical View of Domain Structure for InterPro Entry

O95861

UniProtKB/Swiss-Prot:

BPNT1_HUMAN :
  • O95861
Family:
  • Belongs to the inositol monophosphatase family.
genes like me logo Genes that share domains with BPNT1: view

No data available for Gene Families for BPNT1 Gene

Function for BPNT1 Gene

Molecular function for BPNT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Adenosine 3,5-bisphosphate + H(2)O = adenosine 5-phosphate + phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Uncompetitive inhibition by micromolar concentrations of lithium. Competitive inhibition by inositol 1,4-bisphosphate.
UniProtKB/Swiss-Prot Function: Converts adenosine 3-phosphate 5-phosphosulfate (PAPS) to adenosine 5-phosphosulfate (APS) and 3(2)-phosphoadenosine 5- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6.

Enzyme Numbers (IUBMB) for BPNT1 Gene

Gene Ontology (GO) - Molecular Function for BPNT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity IEA --
GO:0008441 3(2),5-bisphosphate nucleotidase activity IEA --
genes like me logo Genes that share ontologies with BPNT1: view

Phenotypes for BPNT1 Gene

genes like me logo Genes that share phenotypes with BPNT1: view

Animal Models for BPNT1 Gene

MGI Knock Outs for BPNT1:

Animal Model Products

CRISPR Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for BPNT1 Gene

Localization for BPNT1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BPNT1 Gene COMPARTMENTS Subcellular localization image for BPNT1 gene
Compartment Confidence
cytosol 4
mitochondrion 3
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for BPNT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with BPNT1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for BPNT1 Gene

Pathways for BPNT1 Gene

genes like me logo Genes that share pathways with BPNT1: view

Pathways by source for BPNT1 Gene

Interacting Proteins for BPNT1 Gene

Gene Ontology (GO) - Biological Process for BPNT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process TAS 10224133
GO:0006805 xenobiotic metabolic process TAS --
GO:0007399 nervous system development TAS 10224133
GO:0016311 dephosphorylation TAS 10224133
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with BPNT1: view

Compounds for BPNT1 Gene

(9) HMDB Compounds for BPNT1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine 3',5'-diphosphate
  • 3,5-Diphosphoadenosine
1053-73-2
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine phosphosulfate
  • Adenosine Phosphosulfate
485-84-7
Lithium
  • Li
7439-93-2
Magnesium
  • Magnesium
7439-95-4
genes like me logo Genes that share compounds with BPNT1: view

Transcripts for BPNT1 Gene

Unigene Clusters for BPNT1 Gene

3(2), 5-bisphosphate nucleotidase 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BPNT1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BPNT1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - -
SP2: -
SP3: -
SP4: - - -

Relevant External Links for BPNT1 Gene

GeneLoc Exon Structure for
BPNT1
ECgene alternative splicing isoforms for
BPNT1

Expression for BPNT1 Gene

mRNA expression in normal human tissues for BPNT1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BPNT1 Gene

SOURCE GeneReport for Unigene cluster for BPNT1 Gene Hs.406134

mRNA Expression by UniProt/SwissProt for BPNT1 Gene

O95861-BPNT1_HUMAN
Tissue specificity: Highly expressed in kidney, liver, pancreas and heart. Detected at lower levels in brain, placenta, lung and skeletal muscle.
genes like me logo Genes that share expressions with BPNT1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for BPNT1 Gene

Orthologs for BPNT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for BPNT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BPNT1 35
  • 99.89 (n)
  • 100 (a)
BPNT1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BPNT1 35
  • 90.04 (n)
  • 93.18 (a)
BPNT1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BPNT1 35
  • 91.99 (n)
  • 95.13 (a)
BPNT1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bpnt1 35
  • 85.06 (n)
  • 91.88 (a)
Bpnt1 16
Bpnt1 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BPNT1 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BPNT1 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bpnt1 35
  • 84.96 (n)
  • 91.23 (a)
chicken
(Gallus gallus)
Aves BPNT1 35
  • 77.02 (n)
  • 80.72 (a)
BPNT1 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BPNT1 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bpnt1 35
  • 74.13 (n)
  • 81.17 (a)
Str.3809 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14199 35
zebrafish
(Danio rerio)
Actinopterygii bpnt1 35
  • 68.19 (n)
  • 74.84 (a)
bpnt1 36
  • 74 (a)
OneToOne
Dr.15386 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004654 35
  • 54.08 (n)
  • 53.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7789 35
  • 52.98 (n)
  • 51.66 (a)
CG7789 36
  • 50 (a)
OneToOne
CG7789 37
  • 50 (a)
worm
(Caenorhabditis elegans)
Secernentea tag-231 35
  • 55.36 (n)
  • 48.1 (a)
tag-231 36
  • 41 (a)
OneToOne
ZK430.2 37
  • 42 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15563 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToOne
Species with no ortholog for BPNT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BPNT1 Gene

ENSEMBL:
Gene Tree for BPNT1 (if available)
TreeFam:
Gene Tree for BPNT1 (if available)

Paralogs for BPNT1 Gene

Paralogs for BPNT1 Gene

Selected SIMAP similar genes for BPNT1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with BPNT1: view

Variants for BPNT1 Gene

Sequence variations from dbSNP and Humsavar for BPNT1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs904327 -- 220,089,732(+) AGCGC(G/T)TTATC utr-variant-5-prime
rs904328 -- 220,059,455(+) ATTAA(C/T)TGTAT intron-variant
rs1051435 -- 220,057,585(-) TGAGA(G/T)ATTAT utr-variant-3-prime
rs1137752 -- 220,058,801(-) ctgta(A/G)tccca utr-variant-3-prime
rs1137753 -- 220,058,711(-) tctct(A/G)caaaa utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for BPNT1 Gene

Variant ID Type Subtype PubMed ID
nsv832636 CNV Loss 17160897
nsv4632 CNV Insertion 18451855

Relevant External Links for BPNT1 Gene

HapMap Linkage Disequilibrium report
BPNT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BPNT1 Gene

Disorders for BPNT1 Gene

(1) University of Copenhagen DISEASES for BPNT1 Gene

Relevant External Links for BPNT1

Genetic Association Database (GAD)
BPNT1
Human Genome Epidemiology (HuGE) Navigator
BPNT1
genes like me logo Genes that share disorders with BPNT1: view

No data available for UniProtKB/Swiss-Prot for BPNT1 Gene

Publications for BPNT1 Gene

  1. Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate. (PMID: 10224133) Spiegelberg B.D. … York J.D. (J. Biol. Chem. 1999) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty S.E. … . (PLoS Genet. 2010) 3 48
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for BPNT1 Gene

Sources for BPNT1 Gene

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