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BPNT1 Gene

protein-coding   GIFtS: 60
GCID: GC01M220230

3'(2'), 5'-Bisphosphate Nucleotidase 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
3'(2'), 5'-Bisphosphate Nucleotidase 11 2     BPntase2
Bisphosphate 3'-Nucleotidase 12 3     HEL202
PIP2 3     PAP-inositol-1,4-phosphatase2
PAP-Inositol 1,4-Phosphatase2 3     Epididymis Luminal Protein 202
EC 3.1.3.73 8     EC 3.1.38
3'(2'),5'-Bisphosphate Nucleotidase 12     

External Ids:    HGNC: 10961   Entrez Gene: 103802   Ensembl: ENSG000001628137   OMIM: 6040535   UniProtKB: O958613   

Export aliases for BPNT1 gene to outside databases

Previous GC identifers: GC01M218827 GC01M216074 GC01M216777 GC01M217287 GC01M216619 GC01M218297 GC01M190905


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for BPNT1 Gene:
BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent
phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive
inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role
in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may
account for lithium-induced nephrotoxicity. (provided by RefSeq, Jul 2008)

GeneCards Summary for BPNT1 Gene:
BPNT1 (3'(2'), 5'-bisphosphate nucleotidase 1) is a protein-coding gene. GO annotations related to this gene include 3'(2'),5'-bisphosphate nucleotidase activity and magnesium ion binding. An important paralog of this gene is IMPAD1.

UniProtKB/Swiss-Prot: BPNT1_HUMAN, O95861
Function: Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and
3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol
1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P,
Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the BPNT1 gene promoter:
         FOXD3   Ik-3   GATA-2   Arnt   GATA-1   HEN1   POU2F1   POU2F1a   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidBPNT1 promoter sequence
   Search Chromatin IP Primers for BPNT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat BPNT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q41   Ensembl cytogenetic band:  1q41   HGNC cytogenetic band: 1q42

BPNT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
BPNT1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M220230:  view genomic region     (about GC identifiers)

Start:
220,230,824 bp from pter      End:
220,263,804 bp from pter
Size:
32,981 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: BPNT1_HUMAN, O95861 (See protein sequence)
Recommended Name: 3'(2'),5'-bisphosphate nucleotidase 1  
Size: 308 amino acids; 33392 Da
Cofactor: Magnesium
1 PDB 3D structure from and Proteopedia for BPNT1:
2WEF (3D)    
Secondary accessions: A8K7C8 D3DTA9 Q8WVL5 Q9UGJ3
Alternative splicing: 2 isoforms:  O95861-1   O95861-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for BPNT1: NX_O95861

Explore proteomics data for BPNT1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys49
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for BPNT1 (O95861)
     VWVDPLD  AVGGKLTD  EEILKQPCPSQYSAIKEEDLVVWVDP  VLRVGGAGNKIIQLIEGKASAYVFASPGCKKWDTCAPEVIL 


    See BPNT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001273078.1  NP_001273079.1  NP_001273080.1  NP_006076.4  

    ENSEMBL proteins: 
     ENSP00000446828   ENSP00000346862   ENSP00000446953   ENSP00000446850   ENSP00000448740  
     ENSP00000449883   ENSP00000318852   ENSP00000410348   ENSP00000444398  
    Reactome Protein details: O95861

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR020550 Inositol_monophosphatase_CS
     IPR000760 Inositol_monophosphatase
     IPR020583 Inositol_monoP_metal-BS

    Graphical View of Domain Structure for InterPro Entry O95861

    ProtoNet protein and cluster: O95861

    UniProtKB/Swiss-Prot: BPNT1_HUMAN, O95861
    Similarity: Belongs to the inositol monophosphatase family


    Find genes that share domains with BPNT1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: BPNT1_HUMAN, O95861
    Function: Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and
    3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol
    1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P,
    Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6
    Catalytic activity: Adenosine 3',5'-bisphosphate + H(2)O = adenosine 5'-phosphate + phosphate
    Enzyme regulation: Uncompetitive inhibition by micromolar concentrations of lithium. Competitive inhibition by
    inositol 1,4-bisphosphate

         Enzyme Numbers (IUBMB): EC 3.1.3.71 2 EC 3.1.32

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IEA--
    GO:0004441inositol-1,4-bisphosphate 1-phosphatase activity IEA--
    GO:00084413'(2'),5'-bisphosphate nucleotidase activity IEA--
         
    Find genes that share ontologies with BPNT1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for BPNT1:
     Decreased focal adhesion (FA)  

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Bpnt1):
     homeostasis/metabolism  liver/biliary system  mortality/aging  no phenotypic analysis 

    Find genes that share phenotypes with BPNT1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Bpnt1tm1Yrk for BPNT1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for BPNT1
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    hsa-miR-607 hsa-miR-206 hsa-miR-613 hsa-miR-1 hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidBPNT1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion3
    extracellular1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    Find genes that share ontologies with BPNT1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for BPNT1 About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    2Biological oxidations
    Biological oxidations0.56
    Cytosolic sulfonation of small molecules0.00
    Phase II conjugation0.56
    3Sulfur metabolism
    Sulfur metabolism


    Find genes that share SuperPaths with BPNT1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for BPNT1 (see all 15)
        MIF Regulation of Innate Immune Cells
    STAT3 Pathway
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C

    1 Reactome Pathway for BPNT1
        Cytosolic sulfonation of small molecules


    2 Kegg Pathways  (Kegg details for BPNT1):
        Sulfur metabolism
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for BPNT1
    Interactions:

        Search GeneGlobe Interaction Network for BPNT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for BPNT1 (O958613 ENSP000003188524) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDA1Q9BW613I2D: score=1 
    IKBKEQ141643I2D: score=1 
    TRAF6Q9Y4K33I2D: score=1 
    UBA5Q9GZZ93I2D: score=1 
    CHST11ENSP000003057254STRING: ENSP00000305725
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006139nucleobase-containing compound metabolic process TAS10224133
    GO:0006805xenobiotic metabolic process TAS--
    GO:0007399nervous system development TAS10224133
    GO:0016311dephosphorylation TAS10224133
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with BPNT1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for BPNT1

    9 HMDB Compounds for BPNT1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine 3',5'-diphosphate3,5-Diphosphoadenosine (see all 10)1053-73-2--
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine phosphosulfateAdenosine Phosphosulfate (see all 13)485-84-7--
    LithiumLi (see all 5)7439-93-2--
    MagnesiumMagnesium (see all 2)7439-95-4--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    Phosphoadenosine phosphosulfate3'-Phospho-5'-adenylyl sulfate (see all 9)482-67-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    ZolpidemAmbien (see all 7)82626-48-0--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for BPNT1 gene (4 alternative transcripts): 
    NM_001286149.1  NM_001286150.1  NM_001286151.1  NM_006085.5  

    Unigene Cluster for BPNT1:

    3'(2'), 5'-bisphosphate nucleotidase 1
    Hs.406134  [show with all ESTs]
    Unigene Representative Sequence: NM_006085
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000469520 ENST00000354807 ENST00000482136 ENST00000463953 ENST00000498791
    ENST00000480959 ENST00000548668 ENST00000498237 ENST00000322067(uc001hma.3 uc010pug.2 uc010puh.2)
    ENST00000414869 ENST00000544404
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    hsa-miR-607 hsa-miR-206 hsa-miR-613 hsa-miR-1 hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidBPNT1 3' UTR sequence
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    Additional mRNA sequence: 

    AJ249339.1 AK021941.1 AK291943.1 AK298476.1 AK300777.1 AK315962.1 BC017801.1 

    11 DOTS entries:

    DT.100026759  DT.40288530  DT.309993  DT.97843381  DT.100787582  DT.102823315  DT.91729031  DT.100026758 
    DT.121443346  DT.91729044  DT.100026757 

    Selected AceView cDNA sequences (see all 106):

    BP345650 CR599062 BP374906 AL600860 CB137379 CB110606 BP373057 AA206984 
    CA488991 AL528197 BP343778 BE297198 BU845985 BM467293 CB116894 AL583334 
    AU119997 BI834802 BI670168 BE539236 CB128808 CD370371 BG387025 BQ020557 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for BPNT1    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
    SP1:                    -                                   -                           
    SP2:                    -                                                               
    SP3:                                                        -                           
    SP4:                    -     -                             -                           


    ECgene alternative splicing isoforms for BPNT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    BPNT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAATGTTCT
    BPNT1 Expression
    About this image

    BPNT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    BPNT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.406134

    UniProtKB/Swiss-Prot: BPNT1_HUMAN, O95861
    Tissue specificity: Highly expressed in kidney, liver, pancreas and heart. Detected at lower levels in brain,
    placenta, lung and skeletal muscle

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for BPNT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for BPNT1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Bpnt11 , 5 bisphosphate 3'-nucleotidase 11, 5 85.06(n)1
    91.88(a)1
      1 (89.49 cM)5
    238271  NM_011794.31  NP_035924.21 
     1853321495 
    chicken
    (Gallus gallus)
    Aves BPNT11 3'(2'), 5'-bisphosphate nucleotidase 1 77.02(n)
    80.72(a)
      421347  NM_001012874.2  NP_001012892.2 
    lizard
    (Anolis carolinensis)
    Reptilia BPNT16
    3'(2'), 5'-bisphosphate nucleotidase 1
    84(a)
    1 ↔ 1
    1(243259730-243271730)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.38092 Transcribed sequence with moderate similarity to protein more 77.49(n)    AL879086.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.153862 Transcribed sequence with weak similarity to protein more 75.3(n)    AL918203.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG77891 , 3 3'(2'),5'-bisphosphate nucleotidase3
    CG77891
    50(a)3
    52.98(n)1
    51.66(a)1
      99C13
    435161  NM_143471.21  NP_651728.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ZK430.23
    tag-2311
    ammonium transport protein3
    tag-2311
    42(a)3
    55.36(n)1
    48.1(a)1
      II(4420303-4422207)3
    1737771  NM_062379.51  NP_494780.11 


    ENSEMBL Gene Tree for BPNT1 (if available)
    TreeFam Gene Tree for BPNT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for BPNT1 gene
    IMPAD12  
    1 SIMAP similar gene for BPNT1 using alignment to 8 protein entries:     BPNT1_HUMAN (see all proteins):
    IMPAD1

    Find genes that share paralogs with BPNT1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for BPNT1 (see all 631)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1151905751,2
    F--220230423(+) AAATCG/ATTGGG 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1816517911,2
    --220230528(+) ACCTCA/TGCCTC 1 -- ds50010--------
    rs1493455041,2
    C--220230603(+) TGCCCA/GGCTAA 1 -- ds50010--------
    rs1862337701,2
    --220230613(+) ATTTTC/TGTATT 1 -- ds50010--------
    rs1909510011,2
    C--220230733(+) CACTGC/TGCCTG 1 -- ds50010--------
    rs1823406731,2
    --220230768(+) AATCTC/TCCTAG 1 -- ds50010--------
    rs118039601,2
    C,F,H--220230785(+) ctgatA/Gtgcag 1 -- ds50017Minor allele frequency- G:0.07NS EA NA CSA WA 538
    rs1414297861,2
    --220230791(+) TGCAGC/TTGAGT 1 -- ds50010--------
    rs1504285671,2
    --220230931(+) TCTCTC/TATTGG 1 -- ut310--------
    rs1382417671,2
    C--220230943(+) AGGAAC/TAGAAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for BPNT1 (220230824 - 220263804 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for BPNT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv4632CNV Insertion18451855
    nsv832636CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing BPNT1
    DNA2.0 Custom Variant and Variant Library Synthesis for BPNT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604053    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for BPNT1:
    Neonatal jaundice

    Find genes that share disorders with BPNT1           About GenesLikeMe

    Genetic Association Database (GAD): BPNT1
    Human Genome Epidemiology (HuGE) Navigator: BPNT1 (1 document)

    Export disorders for BPNT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for BPNT1 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with BPNT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate. (PubMed id 10224133)1, 2, 3, 9 Spiegelberg B.D.... York J.D. (J. Biol. Chem. 1999)
    2. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. (PubMed id 21565611)1 Sang L.... Jackson P.K. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10380 HGNC: 1096 AceView: BPNT1 Ensembl:ENSG00000162813 euGenes: HUgn10380
    ECgene: BPNT1 Kegg: 10380 H-InvDB: BPNT1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for BPNT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for BPNT1 gene:
    Search GeneIP for patents involving BPNT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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