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Aliases for BPNT1 Gene

Aliases for BPNT1 Gene

  • 3'(2'), 5'-Bisphosphate Nucleotidase 1 2
  • 3(2), 5-Bisphosphate Nucleotidase 1 2 3 5
  • Bisphosphate 3-Nucleotidase 1 3 4
  • PAP-Inositol 1,4-Phosphatase 3 4
  • EC 4 63
  • PIP 3 4
  • Testicular Tissue Protein Li 29 3
  • Epididymis Luminal Protein 20 3
  • PAP-Inositol-1,4-Phosphatase 3
  • EC 3.1.3 63
  • BPntase 3
  • HEL20 3

External Ids for BPNT1 Gene

Previous GeneCards Identifiers for BPNT1 Gene

  • GC01M218827
  • GC01M216074
  • GC01M216777
  • GC01M217287
  • GC01M216619
  • GC01M218297
  • GC01M220230
  • GC01M190905

Summaries for BPNT1 Gene

Entrez Gene Summary for BPNT1 Gene

  • BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq, Jul 2008]

GeneCards Summary for BPNT1 Gene

BPNT1 (3'(2'), 5'-Bisphosphate Nucleotidase 1) is a Protein Coding gene. Among its related pathways are Phase II conjugation and Sulfur metabolism. GO annotations related to this gene include magnesium ion binding and 3(2),5-bisphosphate nucleotidase activity. An important paralog of this gene is IMPAD1.

UniProtKB/Swiss-Prot for BPNT1 Gene

  • Converts adenosine 3-phosphate 5-phosphosulfate (PAPS) to adenosine 5-phosphosulfate (APS) and 3(2)-phosphoadenosine 5- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BPNT1 Gene

Genomics for BPNT1 Gene

Regulatory Elements for BPNT1 Gene

Enhancers for BPNT1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BPNT1 on UCSC Golden Path with GeneCards custom track

Promoters for BPNT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BPNT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for BPNT1 Gene

220,057,482 bp from pter
220,090,462 bp from pter
32,981 bases
Minus strand

Genomic View for BPNT1 Gene

Genes around BPNT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BPNT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BPNT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BPNT1 Gene

Proteins for BPNT1 Gene

  • Protein details for BPNT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    3(2),5-bisphosphate nucleotidase 1
    Protein Accession:
    Secondary Accessions:
    • A8K7C8
    • B4DPS5
    • B4DUS9
    • D3DTA9
    • Q8WVL5
    • Q9UGJ3

    Protein attributes for BPNT1 Gene

    308 amino acids
    Molecular mass:
    33392 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for BPNT1 Gene

    Alternative splice isoforms for BPNT1 Gene


neXtProt entry for BPNT1 Gene

Proteomics data for BPNT1 Gene at MOPED

Post-translational modifications for BPNT1 Gene

  • Ubiquitination at Lys 49
  • Modification sites at PhosphoSitePlus

Domains & Families for BPNT1 Gene

Gene Families for BPNT1 Gene

Protein Domains for BPNT1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the inositol monophosphatase family.
  • Belongs to the inositol monophosphatase family.
genes like me logo Genes that share domains with BPNT1: view

Function for BPNT1 Gene

Molecular function for BPNT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Adenosine 3,5-bisphosphate + H(2)O = adenosine 5-phosphate + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Uncompetitive inhibition by micromolar concentrations of lithium. Competitive inhibition by inositol 1,4-bisphosphate.
UniProtKB/Swiss-Prot Function:
Converts adenosine 3-phosphate 5-phosphosulfate (PAPS) to adenosine 5-phosphosulfate (APS) and 3(2)-phosphoadenosine 5- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6.

Enzyme Numbers (IUBMB) for BPNT1 Gene

genes like me logo Genes that share phenotypes with BPNT1: view

Animal Models for BPNT1 Gene

MGI Knock Outs for BPNT1:

Animal Model Products

  • Taconic Biosciences Mouse Models for BPNT1

miRNA for BPNT1 Gene

miRTarBase miRNAs that target BPNT1

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BPNT1 Gene

Localization for BPNT1 Gene

Subcellular locations from

Jensen Localization Image for BPNT1 Gene COMPARTMENTS Subcellular localization image for BPNT1 gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 3
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for BPNT1 Gene

Pathways & Interactions for BPNT1 Gene

genes like me logo Genes that share pathways with BPNT1: view

Pathways by source for BPNT1 Gene

Interacting Proteins for BPNT1 Gene

Gene Ontology (GO) - Biological Process for BPNT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0007399 nervous system development TAS 10224133
GO:0050427 3-phosphoadenosine 5-phosphosulfate metabolic process TAS --
genes like me logo Genes that share ontologies with BPNT1: view

No data available for SIGNOR curated interactions for BPNT1 Gene

Drugs & Compounds for BPNT1 Gene

(4) Drugs for BPNT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lithium Approved Pharma 0
Zolpidem Approved Pharma Full agonist, Allosteric regulator 98
Adenosine monophosphate Approved Nutra 0
Magnesium Nutra 0

(6) Additional Compounds for BPNT1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
Adenosine phosphosulfate
  • Adenosine 5'-phosphosulfate
  • Adenosine 5'-phosphosulphate
  • Adenosine 5'-sulphatophosphate
  • Adenosine Phosphosulfate
  • Adenosine Phosphosulphate
  • NFB Orthophosphate
  • O-Phosphoric acid
  • Ortho-phosphate
  • Orthophosphate (PO43-)
  • Orthophosphate(3-)
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
genes like me logo Genes that share compounds with BPNT1: view

Transcripts for BPNT1 Gene

Unigene Clusters for BPNT1 Gene

3(2), 5-bisphosphate nucleotidase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BPNT1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - -
SP2: -
SP3: -
SP4: - - -

Relevant External Links for BPNT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BPNT1 Gene

mRNA expression in normal human tissues for BPNT1 Gene

Protein differential expression in normal tissues from HIPED for BPNT1 Gene

This gene is overexpressed in Skin (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for BPNT1 Gene

SOURCE GeneReport for Unigene cluster for BPNT1 Gene Hs.406134

mRNA Expression by UniProt/SwissProt for BPNT1 Gene

Tissue specificity: Highly expressed in kidney, liver, pancreas and heart. Detected at lower levels in brain, placenta, lung and skeletal muscle.
genes like me logo Genes that share expression patterns with BPNT1: view

Protein tissue co-expression partners for BPNT1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for BPNT1 Gene

Orthologs for BPNT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for BPNT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BPNT1 35
  • 90.04 (n)
  • 93.18 (a)
BPNT1 36
  • 93 (a)
(Canis familiaris)
Mammalia BPNT1 35
  • 91.99 (n)
  • 95.13 (a)
BPNT1 36
  • 95 (a)
(Mus musculus)
Mammalia Bpnt1 35
  • 85.06 (n)
  • 91.88 (a)
Bpnt1 16
Bpnt1 36
  • 92 (a)
(Pan troglodytes)
Mammalia BPNT1 35
  • 99.89 (n)
  • 100 (a)
BPNT1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Bpnt1 35
  • 84.96 (n)
  • 91.23 (a)
(Monodelphis domestica)
Mammalia BPNT1 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia BPNT1 36
  • 87 (a)
(Gallus gallus)
Aves BPNT1 35
  • 77.02 (n)
  • 80.72 (a)
BPNT1 36
  • 80 (a)
(Anolis carolinensis)
Reptilia BPNT1 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia bpnt1 35
  • 74.13 (n)
  • 81.17 (a)
Str.3809 35
(Danio rerio)
Actinopterygii bpnt1 35
  • 68.19 (n)
  • 74.84 (a)
Dr.15386 35
bpnt1 36
  • 74 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14199 35
fruit fly
(Drosophila melanogaster)
Insecta CG7789 37
  • 50 (a)
CG7789 35
  • 52.98 (n)
  • 51.66 (a)
CG7789 36
  • 50 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004654 35
  • 54.08 (n)
  • 53.64 (a)
(Caenorhabditis elegans)
Secernentea ZK430.2 37
  • 42 (a)
tag-231 35
  • 55.36 (n)
  • 48.1 (a)
tag-231 36
  • 41 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15563 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
Species with no ortholog for BPNT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BPNT1 Gene

Gene Tree for BPNT1 (if available)
Gene Tree for BPNT1 (if available)

Paralogs for BPNT1 Gene

Paralogs for BPNT1 Gene

(1) SIMAP similar genes for BPNT1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with BPNT1: view

Variants for BPNT1 Gene

Sequence variations from dbSNP and Humsavar for BPNT1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs904327 -- 220,089,732(+) AGCGC(G/T)TTATC utr-variant-5-prime
rs904328 -- 220,059,455(+) ATTAA(C/T)TGTAT intron-variant
rs1137752 -- 220,058,801(-) ctgta(A/G)tccca utr-variant-3-prime
rs1137753 -- 220,058,711(-) tctct(A/G)caaaa utr-variant-3-prime
rs1146773 -- 220,066,106(-) GAAAA(A/G)CAGCA intron-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for BPNT1 Gene

Variant ID Type Subtype PubMed ID
nsv832636 CNV Loss 17160897
nsv4632 CNV Insertion 18451855

Variation tolerance for BPNT1 Gene

Residual Variation Intolerance Score: 44.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.64; 31.45% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for BPNT1 Gene

Disorders for BPNT1 Gene

Relevant External Links for BPNT1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for BPNT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BPNT1 Gene

Publications for BPNT1 Gene

  1. Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate. (PMID: 10224133) Spiegelberg B.D. … York J.D. (J. Biol. Chem. 1999) 2 3 4 23 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  4. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. (PMID: 21565611) Sang L. … Jackson P.K. (Cell 2011) 3
  5. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty S.E. … . (PLoS Genet. 2010) 3

Products for BPNT1 Gene

Sources for BPNT1 Gene