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Aliases for BPIFC Gene

Aliases for BPIFC Gene

  • BPI Fold Containing Family C 2 3 5
  • Bactericidal/Permeability-Increasing Protein-Like 2 2 3 4
  • BPI-Like 2 3 4
  • BPIL2 3 4

External Ids for BPIFC Gene

Previous HGNC Symbols for BPIFC Gene

  • BPIL2

Previous GeneCards Identifiers for BPIFC Gene

  • GC22M032810

Summaries for BPIFC Gene

GeneCards Summary for BPIFC Gene

BPIFC (BPI Fold Containing Family C) is a Protein Coding gene. GO annotations related to this gene include lipid binding and lipopolysaccharide binding. An important paralog of this gene is BPI.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BPIFC Gene

Genomics for BPIFC Gene

Regulatory Elements for BPIFC Gene

Enhancers for BPIFC Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around BPIFC on UCSC Golden Path with GeneCards custom track

Genomic Location for BPIFC Gene

32,413,845 bp from pter
32,464,484 bp from pter
50,640 bases
Minus strand

Genomic View for BPIFC Gene

Genes around BPIFC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BPIFC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BPIFC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BPIFC Gene

Proteins for BPIFC Gene

  • Protein details for BPIFC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BPI fold-containing family C protein
    Protein Accession:
    Secondary Accessions:
    • A2RRF1

    Protein attributes for BPIFC Gene

    507 amino acids
    Molecular mass:
    56469 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BPIFC Gene


neXtProt entry for BPIFC Gene

Proteomics data for BPIFC Gene at MOPED

Post-translational modifications for BPIFC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for BPIFC Gene

No data available for DME Specific Peptides for BPIFC Gene

Domains & Families for BPIFC Gene

Gene Families for BPIFC Gene

Suggested Antigen Peptide Sequences for BPIFC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
genes like me logo Genes that share domains with BPIFC: view

Function for BPIFC Gene

Gene Ontology (GO) - Molecular Function for BPIFC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005543 phospholipid binding NAS 12185532
genes like me logo Genes that share ontologies with BPIFC: view
genes like me logo Genes that share phenotypes with BPIFC: view

Animal Model Products

  • Taconic Biosciences Mouse Models for BPIFC

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for BPIFC Gene

Localization for BPIFC Gene

Subcellular locations from UniProtKB/Swiss-Prot for BPIFC Gene


Subcellular locations from

Jensen Localization Image for BPIFC Gene COMPARTMENTS Subcellular localization image for BPIFC gene
Compartment Confidence
extracellular 3
cytoskeleton 1
cytosol 1
lysosome 1
mitochondrion 1
peroxisome 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for BPIFC Gene

Pathways & Interactions for BPIFC Gene

SuperPathways for BPIFC Gene

No Data Available

Interacting Proteins for BPIFC Gene

Gene Ontology (GO) - Biological Process for BPIFC Gene


No data available for Pathways by source and SIGNOR curated interactions for BPIFC Gene

Drugs & Compounds for BPIFC Gene

No Compound Related Data Available

Transcripts for BPIFC Gene

mRNA/cDNA for BPIFC Gene

(7) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for BPIFC Gene

BPI fold containing family C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BPIFC Gene

No ASD Table

Relevant External Links for BPIFC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BPIFC Gene

mRNA expression in normal human tissues for BPIFC Gene

mRNA differential expression in normal tissues according to GTEx for BPIFC Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x25.3) and Skin - Sun Exposed (Lower leg) (x24.6).

SOURCE GeneReport for Unigene cluster for BPIFC Gene Hs.372939

mRNA Expression by UniProt/SwissProt for BPIFC Gene

Tissue specificity: Detected in the basal layer of the epidermis from inflammatory skin from psoriasis patients, but not in normal skin.
genes like me logo Genes that share expression patterns with BPIFC: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for BPIFC Gene

Orthologs for BPIFC Gene

This gene was present in the common ancestor of chordates.

Orthologs for BPIFC Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BPIFC 35
  • 86.82 (n)
  • 83 (a)
  • 83 (a)
(Canis familiaris)
Mammalia BPIFC 35
  • 87.42 (n)
  • 86.17 (a)
  • 85 (a)
(Mus musculus)
Mammalia Bpifc 35
  • 78.95 (n)
  • 71.91 (a)
Bpifc 16
Bpifc 36
  • 71 (a)
(Pan troglodytes)
Mammalia BPIL2 35
  • 99.08 (n)
  • 98.42 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Bpifc 35
  • 80.35 (n)
  • 74.25 (a)
(Monodelphis domestica)
Mammalia BPIFC 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia BPIFC 36
  • 67 (a)
(Gallus gallus)
Aves BPIFCB 35
  • 52.77 (n)
  • 33.91 (a)
  • 34 (a)
(Anolis carolinensis)
Reptilia BPIFC 36
  • 26 (a)
(Danio rerio)
Actinopterygii bpifcl 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
Species with no ortholog for BPIFC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BPIFC Gene

Gene Tree for BPIFC (if available)
Gene Tree for BPIFC (if available)

Paralogs for BPIFC Gene

Paralogs for BPIFC Gene

(3) SIMAP similar genes for BPIFC Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BPIFC: view

Variants for BPIFC Gene

Sequence variations from dbSNP and Humsavar for BPIFC Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs2076051 - 32,435,822(+) GGAGC(A/G)CAAAA reference, missense
rs5998478 - 32,415,965(+) ATTGG(A/G)CAGAG reference, missense
rs5994570 - 32,435,724(+) AGTGA(C/G)ATTGA reference, missense
rs35856742 - 32,414,391(+) ATGTT(G/T)CATAC reference, missense
rs2076050 -- 32,435,553(+) CACTC(C/T)ACAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BPIFC Gene

Variant ID Type Subtype PubMed ID
nsv459874 CNV Gain 19166990
esv268198 CNV Insertion 20981092
esv2658664 CNV Deletion 23128226
esv270832 CNV Insertion 20981092
nsv526513 CNV Loss 19592680
nsv519086 CNV Loss 19592680

Variation tolerance for BPIFC Gene

Residual Variation Intolerance Score: 90.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.42; 81.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BPIFC Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BPIFC Gene

Disorders for BPIFC Gene

Relevant External Links for BPIFC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for BPIFC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BPIFC Gene

Publications for BPIFC Gene

  1. Three new human members of the lipid transfer/lipopolysaccharide binding protein family (LT/LBP). (PMID: 12185532) Mulero J.J. … Rupp F. (Immunogenetics 2002) 3 4 67
  2. Genome-wide meta-analysis identifies new susceptibility loci for migraine. (PMID: 23793025) Anttila V. … . (Nat. Genet. 2013) 3
  3. Large-scale identification of human genes implicated in epidermal barrier function. (PMID: 17562024) Toulza E. … Guerrin M. (Genome Biol. 2007) 3
  4. Phylogenetic and evolutionary analysis of the PLUNC gene family. (PMID: 14739326) Bingle C.D. … Craven C.J. (Protein Sci. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for BPIFC Gene

Sources for BPIFC Gene