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Aliases for BPIFC Gene

Aliases for BPIFC Gene

  • BPI Fold Containing Family C 2 3
  • Bactericidal/Permeability-Increasing Protein-Like 2 2 3 4
  • BPIL2 3 4 6
  • BPI-Like 2 3 4
  • BPI Fold-Containing Family C Protein 3

External Ids for BPIFC Gene

Previous HGNC Symbols for BPIFC Gene

  • BPIL2

Previous GeneCards Identifiers for BPIFC Gene

  • GC22M032810

Summaries for BPIFC Gene

GeneCards Summary for BPIFC Gene

BPIFC (BPI Fold Containing Family C) is a Protein Coding gene. GO annotations related to this gene include phospholipid binding and lipopolysaccharide binding. An important paralog of this gene is BPI.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BPIFC Gene

Genomics for BPIFC Gene

Genomic Location for BPIFC Gene

32,413,847 bp from pter
32,464,484 bp from pter
50,638 bases
Minus strand

Genomic View for BPIFC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BPIFC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BPIFC Gene

No data available for Regulatory Elements for BPIFC Gene

Proteins for BPIFC Gene

  • Protein details for BPIFC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    BPI fold-containing family C protein
    Protein Accession:
    Secondary Accessions:
    • A2RRF1

    Protein attributes for BPIFC Gene

    507 amino acids
    Molecular mass:
    56469 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BPIFC Gene


neXtProt entry for BPIFC Gene

Proteomics data for BPIFC Gene at MOPED

Post-translational modifications for BPIFC Gene

  • Glycosylation at Asn79, Asn92, Asn113, Asn213, Asn225, Asn257, Asn301, Asn355, Asn372, and Asn415
  • Modification sites at PhosphoSitePlus

Other Protein References for BPIFC Gene

No data available for DME Specific Peptides for BPIFC Gene

Domains for BPIFC Gene

Gene Families for BPIFC Gene

  • BPIF :BPI fold containing

Graphical View of Domain Structure for InterPro Entry



  • Q8NFQ6
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
genes like me logo Genes that share domains with BPIFC: view

No data available for Suggested Antigen Peptide Sequences for BPIFC Gene

Function for BPIFC Gene

Gene Ontology (GO) - Molecular Function for BPIFC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding NAS 12185532
GO:0005543 phospholipid binding NAS 12185532
GO:0008289 lipid binding --
genes like me logo Genes that share ontologies with BPIFC: view

Phenotypes for BPIFC Gene

GenomeRNAi human phenotypes for BPIFC:
genes like me logo Genes that share phenotypes with BPIFC: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BPIFC

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BPIFC Gene

Localization for BPIFC Gene

Subcellular locations from UniProtKB/Swiss-Prot for BPIFC Gene


Gene Ontology (GO) - Cellular Components for BPIFC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with BPIFC: view

No data available for Subcellular locations from COMPARTMENTS for BPIFC Gene

Pathways for BPIFC Gene

SuperPathways for BPIFC Gene

No Data Available

Interacting Proteins for BPIFC Gene

Gene Ontology (GO) - Biological Process for BPIFC Gene


No data available for Pathways by source for BPIFC Gene

Transcripts for BPIFC Gene

mRNA/cDNA for BPIFC Gene

Unigene Clusters for BPIFC Gene

BPI fold containing family C:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BPIFC

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BPIFC Gene

No ASD Table

Relevant External Links for BPIFC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BPIFC Gene

mRNA expression in normal human tissues for BPIFC Gene

mRNA differential expression in normal tissues according to GTEx for BPIFC Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (25.3) and Skin - Sun Exposed (Lower leg) (24.6).

SOURCE GeneReport for Unigene cluster for BPIFC Gene Hs.372939

mRNA Expression by UniProt/SwissProt for BPIFC Gene

Tissue specificity: Detected in the basal layer of the epidermis from inflammatory skin from psoriasis patients, but not in normal skin
genes like me logo Genes that share expressions with BPIFC: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Expression partners for BPIFC Gene

Orthologs for BPIFC Gene

This gene was present in the common ancestor of chordates.

Orthologs for BPIFC Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BPIFC 35
  • 86.82 (n)
  • 83 (a)
  • 83 (a)
(Canis familiaris)
Mammalia BPIFC 35
  • 87.42 (n)
  • 86.17 (a)
  • 85 (a)
(Mus musculus)
Mammalia Bpifc 35
  • 78.95 (n)
  • 71.91 (a)
Bpifc 16
Bpifc 36
  • 71 (a)
(Pan troglodytes)
Mammalia BPIL2 35
  • 99.08 (n)
  • 98.42 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Bpifc 35
  • 80.35 (n)
  • 74.25 (a)
(Monodelphis domestica)
Mammalia BPIFC 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia BPIFC 36
  • 67 (a)
(Gallus gallus)
Aves BPIFCB 35
  • 52.77 (n)
  • 33.91 (a)
  • 34 (a)
(Anolis carolinensis)
Reptilia BPIFC 36
  • 26 (a)
(Danio rerio)
Actinopterygii bpifcl 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
Species with no ortholog for BPIFC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BPIFC Gene

Gene Tree for BPIFC (if available)
Gene Tree for BPIFC (if available)

Paralogs for BPIFC Gene

Paralogs for BPIFC Gene

Selected SIMAP similar genes for BPIFC Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with BPIFC: view

Variants for BPIFC Gene

Sequence variations from dbSNP and Humsavar for BPIFC Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs713760 -- 32,417,352(+) AAAAA(A/T)TTTTT intron-variant
rs722693 -- 32,418,545(+) TGCCA(A/G)ATGTC intron-variant
rs736123 -- 32,443,775(+) ATTGT(A/G)TCCAC intron-variant
rs738258 -- 32,415,287(+) cagac(C/T)gggac intron-variant
rs738259 -- 32,423,577(+) GTGTG(G/T)GTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BPIFC Gene

Variant ID Type Subtype PubMed ID
nsv459874 CNV Gain 19166990
esv268198 CNV Insertion 20981092
esv2658664 CNV Deletion 23128226
esv270832 CNV Insertion 20981092
nsv526513 CNV Loss 19592680
nsv519086 CNV Loss 19592680

Relevant External Links for BPIFC Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BPIFC Gene

Disorders for BPIFC Gene

No disorders were found for BPIFC Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for BPIFC Gene

Publications for BPIFC Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  2. Three new human members of the lipid transfer/lipopolysaccharide binding protein family (LT/LBP). (PMID: 12185532) Mulero J.J. … Rupp F. (Immunogenetics 2002) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Phylogenetic and evolutionary analysis of the PLUNC gene family. (PMID: 14739326) Bingle C.D. … Craven C.J. (Protein Sci. 2004) 3
  5. Large-scale identification of human genes implicated in epidermal barrier function. (PMID: 17562024) Toulza E. … Guerrin M. (Genome Biol. 2007) 3

Products for BPIFC Gene

Sources for BPIFC Gene

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